Micellar two-phase cosmetic spray in a non-aerosol fine mist package

Abstract

The makeup remover composition comprises an oil mixture comprising one or more liquid branched or linear alkanes having a carbon chain length of C11 to C20, including isohexadecane and isododecane, one or more emollient esters, at least one polymeric thickener for aqueous systems, at least one polyglyceryl nonionic surfactant, and water in a two-phase micellar system comprising an oil phase and an aqueous phase, wherein the aqueous phase comprises water present at about 30% to about 70% by weight of the makeup remover composition, and the water and oil are present in a water-to-oil ratio of about 1.5:1 to about 1:1.5. The product is removed by wiping without rinsing with water.

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application No. 63 / 387,848, filed December 16, 2022, entitled "MICELLAR BI-PHASE MAKEUP SPRAY IN A NON-AEROSOL FINE MIST PACKAGING," and French Application No. FR2303507, filed April 7, 2023, the entire contents of which are incorporated herein by reference.

[0002] The present invention relates to makeup remover compositions, and more particularly to non-aerosol spray micellar two-phase makeup remover compositions. [Background technology]

[0003] Removing stubborn makeup has always been a challenge and a thorny consumer concern, especially when it comes to waterproof mascara, long-wear foundation, and long-lasting lip products. Typical makeup removers are ineffective at removing stubborn makeup, requiring repeated, forceful tugging and rubbing on the skin and / or delicate eye areas, causing irritation. Some oil-based makeup removers may make makeup removal easier, but they leave an unpleasant, greasy feel on the skin. Additionally, many commercial makeup removers require application using wipes or pads, which can be messy and can soak into the pads, causing the product to drip and waste.

[0004] Spray-type products are very easy to apply and can be applied evenly by rubbing with the hands without the need for wipes or pads, avoiding the tugging of sensitive tissue. The main drawback of existing spray formulations is that they contain a large amount of oil, which gives them a greasy feel and does not leave the skin feeling as fresh and clean as most consumers desire. Other undesirable ingredients in current makeup removers include alcohol, which can dry out the skin, sulfate surfactants, silicones, VOC propellants, and other synthetic ingredients that are unattractive to consumers seeking products containing natural ingredients.

[0005] Therefore, there is a need for a composition that provides easy and effective makeup removal in a spray form that is free of silicones, alcohols, and sulfates and leaves skin feeling clean and refreshed after use. Summary of the Invention

[0006] This disclosure describes exemplary embodiments in accordance with general inventive concepts, but is not intended to limit the scope of the invention in any way. Indeed, the invention described herein is broader than and is not limited by the exemplary embodiments described herein, and terms used herein have their full ordinary meaning.

[0007] The present disclosure, in various embodiments, provides a non-aerosol spray micellar two-phase makeup remover composition.

[0008] According to various embodiments of the present disclosure, a makeup remover composition comprises an oil mixture comprising one or more liquid branched or linear alkanes having a carbon chain length of from C11 to C20, including isohexadecane and isododecane, one or more emollient esters, at least one polymeric thickener for aqueous systems, at least one polyglyceryl nonionic surfactant, and water in a two-phase micellar system comprising an oil phase and an aqueous phase, wherein the aqueous phase comprises water present at about 30% to about 70% by weight of the makeup remover composition, and the water and oil are present in a water to oil ratio of about 1.5:1 to about 1:1.5.

[0009] In one embodiment, the present disclosure provides a makeup remover composition comprising a two-phase micellar system comprising an oil phase and an aqueous phase, the system comprising: a. An oil mixture, i. one or more liquid branched or linear alkanes having a carbon chain length of from C11 to C20, including isohexadecane and isododecane; ii. an oil mixture comprising one or more emollient esters; b. at least one polymeric thickener for aqueous systems; c. at least one polyglyceryl nonionic surfactant; d. water, present in an amount of about 30% to about 70% by weight of the makeup remover composition; The composition provides a makeup remover composition that is a micellar two-phase composition in which water and oil are present in a water to oil ratio of about 1.5:1 to about 1:1.5.

[0010] According to various embodiments, the makeup remover composition is formulated as an aesthetically pleasing two-phase formulation with a phase boundary, allowing for easy non-greasy makeup removal, and is largely or completely free of ingredients that may irritate the skin or eyes.

[0011] In some embodiments, the makeup remover composition is essentially free of silicones.

[0012] In some embodiments, the composition excludes silicones and one or more of alcohol, sulfate-containing compounds, PEG surfactants, xanthan gum, or combinations thereof.

[0013] In various embodiments, the makeup remover composition may further comprise one or more additives including preservatives, fragrances, active agents, and pH adjusters, among other cosmetically acceptable additives.

[0014] In some embodiments, the one or more emollient esters include isopropyl myristate and the at least one polymeric thickener for aqueous systems includes hydroxyethyl cellulose.

[0015] In some embodiments, isohexadecane is present in about 15% to about 30% by weight and isododecane is present in about 10% to about 20% by weight, calculated by weight of the makeup remover composition.

[0016] In some embodiments, isohexadecane is present at about 28% by weight and isododecane is present at about 15% by weight, calculated by weight of the makeup remover composition.

[0017] In some embodiments, the one or more emollient esters are present in an amount of from about 1% to about 8% by weight, calculated by weight of the makeup remover composition.

[0018] In some embodiments, the one or more emollient esters include isopropyl myristate present at about 1% to about 8% by weight, calculated by weight of the makeup remover composition.

[0019] In some embodiments, the total amount of emollient esters does not exceed about 10% total by weight of the makeup remover composition.

[0020] In some embodiments, the at least one polymeric thickener for aqueous systems is present in an amount of from about 0.01% to about 1.0% by weight, calculated on the weight of the makeup remover composition.

[0021] In some embodiments, the at least one polymeric thickener for aqueous systems comprises hydroxyethyl cellulose.

[0022] In some embodiments, the at least one polyglyceryl nonionic surfactant is present in a total amount of from about 0.01% to about 0.2% by weight, calculated by weight of the makeup remover composition.

[0023] In some embodiments, the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate and polyglyceryl dicaprate.

[0024] In some embodiments, the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate present at about 0.025% by weight and polyglyceryl dicaprate present at about 0.025% by weight, calculated by weight of the composition.

[0025] In some embodiments, the makeup remover composition comprises triethyl citrate.

[0026] In some embodiments, the makeup remover composition comprises one or a combination of additives selected from sodium hydroxide, panthenol, hydroxyacetophenone, gluconolactone, myrtrimonium bromide, sodium citrate, sodium chloride, dicaprylyl ether, citric acid, or combinations thereof.

[0027] In some embodiments, the present disclosure provides a makeup remover composition comprising a two-phase micellar system comprising an oil phase and an aqueous phase, the system comprising: a. An oil mixture, i. one or more liquid branched or linear alkanes having a carbon chain length of from C11 to C20, comprising isohexadecane present at about 28% by weight and isododecane present at about 15% by weight; ii. one or more emollient esters comprising isopropyl myristate present at about 1 wt. %; and b. at least one polymeric thickener for aqueous systems comprising hydroxyethyl cellulose present at about 0.025% by weight; c. at least one polyglyceryl nonionic surfactant comprising polyglyceryl-6 caprylate present at about 0.025% by weight and polyglyceryl dicaprate present at about 0.025% by weight; d. water present at about 45% to about 55% by weight; e. triethyl citrate, f. one or a combination of additives selected from sodium hydroxide, panthenol, hydroxyacetophenone, gluconolactone, myrtrimonium bromide, sodium citrate, sodium chloride, dicaprylyl ether, citric acid, or a combination thereof; All amounts are calculated by weight of the makeup remover composition. The composition provides a makeup remover composition that is a micellar two-phase composition in which water and oil are present in a water to oil ratio of about 1:1.

[0028] In some embodiments, the present disclosure provides a product comprising: a container containing a makeup remover composition according to the present invention; an outlet connected to the container, such as a spray nozzle; and a spray device capable of releasing the makeup remover composition from the container through the outlet, the spray nozzle being a fine mist nozzle capable of delivering a mist at a pump volume of about 0.02 ml / pump (ranging from about 0.01 to about 1.0 ml / pump) and having particles (droplets) with an average size of about 80 to about 100 microns, such as micron-scale particles ranging from about 10 microns to about 900 microns, or from about 40 microns to about 300 microns. In some such embodiments, the makeup remover composition contained in the container is transparent or translucent, the term "translucent" referring to the property of a material that transmits light without permitting the identification of alphanumeric characters using a sample 5 mm thick; and "transparent" referring to the property of a material that transmits light and permits the identification of alphanumeric characters using a sample 5 mm thick. In some particular embodiments, the mist droplets are also translucent or transparent.

[0029] The makeup remover composition is applied for use and removed by wiping without rinsing with water.

[0030] These and other aspects of the present invention are set forth in the appended claims and are described in further detail in the detailed description of the invention.

[0031] It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure.

[0032] The features and advantages of the general inventive concept will become apparent from the following detailed description, which proceeds with reference to the accompanying drawings. [Brief explanation of the drawings]

[0033] [Figure 1] 1 is a chart showing the tested characteristics of the makeup remover composition of the present invention. [Figure 2] 1 is a chart showing the tested characteristics of the makeup remover composition of the present invention. [Figure 3] 1 is a chart showing the clinical trial experience of subjects using the makeup remover composition of the present invention and a comparative composition. [Figure 4] 1 is a chart showing the clinical trial experience of subjects using a spray pump versus an aerosol spray with a makeup remover composition of the present invention and a comparative composition, respectively. DETAILED DESCRIPTION OF THE INVENTION

[0034] "Keratinous matrix" and "keratinous tissue" include, but are not limited to, skin, hair, and nails, respectively.

[0035] By "cosmetically acceptable" is meant a carrier that is compatible with any keratin substrate.

[0036] "Silicone-free" means containing less than 5%, less than 4%, less than 3%, less than 2%, less than 1%, or less than 0.1% by weight of silicones, such as silicone polymers selected from dimethicone and other silicone oils, and silicone elastomers, calculated on the total weight of the makeup remover composition.

[0037] "Stability" is evidenced by either or both visual inspection with the naked eye or microscopic examination. For purposes of this specification, a composition that demonstrates physical stability and does not demonstrate phase instability, essentially maintaining two stable phases that are mixed only by agitation, is considered stable. In various embodiments, the compositions of the present invention remain stable at temperatures ranging from about 4°C to about 45°C for at least one month, at least two months, or more, or any value, range, or subrange therebetween. In some embodiments, the makeup remover composition is stable at 25°C for at least one month, at least two months, at least three months, or more, or any value, range, or subrange therebetween. In some embodiments, the makeup remover composition is stable at 37°C for at least one month, at least two months, at least three months, or more, or any value, range, or subrange therebetween. As disclosed and exemplified herein, the makeup remover composition is stable at 4°C for at least one month, at least two months, at least three months, or more, or any value, range, or subrange therebetween. Additionally, the makeup remover composition as disclosed and exemplified herein is stable through at least 10 freeze-thaw cycles.

[0038] According to the present disclosure, the compositions of the present invention overcome the shortcomings of the prior art and provide unexpected benefits such as easy overall makeup removal, easy foundation removal, leaving skin feeling clean, fresh, soft and smooth, easy mascara removal (regular and waterproof mascara) with minimal scrubbing, and no greasy feel or residue.

[0039] In some embodiments, the makeup remover composition is a non-aerosol, silicone-free, alcohol-free, two-phase makeup remover in a spray-type product that provides a fine mist, the aqueous phase is identified as micelle technology, and the ingredients are primarily natural or naturally derived. In some embodiments, the makeup remover composition is two-phase, comprising (by weight) 50% oil and 50% water.

[0040] In various embodiments, the makeup remover composition is shaken or stirred immediately before application to form an emulsion. In some embodiments, the makeup remover composition of the present invention exhibits phase separation after shaking. In some embodiments, the makeup remover composition forms a milky white single phase upon stirring, which separates back into three or more visually distinct phases over a period of up to 24 hours. In some embodiments, the makeup remover composition of the present invention exhibits phase separation after shaking, and after stirring is stopped, exhibits slow initial phase separation, achieving a sufficiently homogeneous emulsion before dispensing. In some embodiments, the makeup remover composition of the present invention exhibits clean container walls with minimal visible droplets, essentially no layer sticking or dragging on the container walls, and no or minimal visible droplets at any phase interface after stirring is stopped. In some embodiments, the makeup remover composition exhibits excellent ability to remove both long-wear mascara and long-wear foundation.

[0041] Spraying makeup remover composition allows the composition to have longer contact time on the skin, thus removing makeup most effectively.The optimized water-to-oil ratio in the range disclosed and exemplified herein provides ideal makeup removal effectiveness for all types of cosmetics.The optimized water level disclosed and exemplified herein eliminates residue on the skin, especially compared with anhydrous, high-oil silicone oil-containing compositions.In addition, the optimized combination and composition of different chain lengths of hydrocarbons in the oil phase provides ideal makeup removal effectiveness, especially for waterproof cosmetics, most especially waterproof mascara.

[0042] Compared to benchmark products containing propellants, silicones, alcohol, and other less desirable ingredients, the makeup remover composition of the present disclosure differs from the benchmark products in that it deviates from aerosol packaging and dispenses the product as a fine mist without the use of aerosolized propellants, resulting in a pleasant mist and improved stability. Furthermore, due to the absence of silicone oils, the makeup remover composition eliminates the greasy, oily after-use feel that is a major drawback of competitive products. Furthermore, the makeup remover composition is free of harsh chemicals (silicones, alcohols, parabens, fragrances, sulfates). The spray format of the makeup remover composition is the most effective in removing makeup compared to traditional micelles that do not use a spray. Furthermore, its two-phase nature removes all types of makeup, including long-wear mascara, with a single swipe. Furthermore, the aqueous phase of the makeup remover composition is micellar, as exemplified herein, which has been shown to facilitate the removal of stubborn makeup without leaving a greasy residue compared to 100% anhydrous competitive formulations, further improving cleansing ability. The makeup remover composition is mild to the skin, non-irritating to the skin and eyes, and provides a clean skin finish reducing the need for rinsing after application, resulting in reduced water usage.

[0043] Expert evaluations of makeup removal efficacy have shown that the makeup remover composition of the present disclosure performs comparable to competitive anhydrous silicone-containing compositions in removing foundation and excels in removing eye and lip cosmetics. Consumer testing has also shown that the makeup remover composition outperforms competitive benchmarks, leaving no greasy residue. The makeup remover composition also ranks highly efficient at removing mascara and is gentle on the skin. In vitro testing has demonstrated that the composition does not adversely affect skin conditions, and osmolality data combined with clinical testing indicates that the makeup remover composition is non-irritating to the eyes.

[0044] According to various embodiments of the present disclosure, a makeup remover composition comprises an oil mixture comprising one or more liquid branched or linear alkanes having carbon chain lengths of C11 to C20, including isohexadecane and isododecane, one or more emollient esters, at least one polymeric thickener for aqueous systems, at least one polyglyceryl nonionic surfactant, and water in a two-phase micellar system comprising an oil phase and an aqueous phase, wherein the aqueous phase comprises water present in an amount of about 30% to about 70% by weight of the makeup remover composition, and the water and oil are present in a water-to-oil ratio of about 1.5:1 to about 1:1.5. Removal of the composition is achieved by wiping, without the need for rinsing or cleaning typically required with compositions containing oil and surfactant, such as benchmark products.

[0045] (i) Liquid branched or linear alkanes

[0046] According to the present disclosure, the makeup remover composition comprises at least one liquid branched or linear alkane having a carbon chain length of C11 to C20. In various embodiments, the liquid alkane can be selected from those having a carbon chain length of C11 to C20. The liquid alkane can be selected from those having a carbon chain length of C11 to C20, or C15 to C19, or one of C11, C12, C13, C14, C15, C16, C17, and C18 to C19. In some specific embodiments, suitable liquid alkanes that can be used in accordance with the present disclosure include hydrocarbon oils containing 8 to 16 carbon atoms, particularly C8 to C16 branched alkanes, such as C8 to C16 isoalkanes. In some exemplary embodiments, such liquid alkanes can be selected from isoparaffins, such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane, and isohexadecane.

[0047] In some embodiments, the at least one liquid branched or linear alkane comprises isohexadecane, C15-19 alkanes, isododecane, undecane, tridecane, and combinations thereof, hi some embodiments, the makeup remover composition comprises two or more liquid branched or linear alkanes.

[0048] In some embodiments, the liquid branched or linear alkane comprises isohexadecane and isododecane.

[0049] In some embodiments, isohexadecane is present in about 15% to about 30% by weight and isododecane is present in about 10% to about 20% by weight, calculated by weight of the makeup remover composition.

[0050] In some embodiments, isohexadecane is present at about 28% by weight and isododecane is present at about 15% by weight, calculated by weight of the makeup remover composition.

[0051] The amount of each of the at least one liquid branched alkane or liquid linear alkane, calculated by weight of the makeup remover composition, is present in the makeup remover composition in a range from about 1% to about 35%, from about 15% to about 30%, or from about 10% to about 20% by weight, or any suitable combination, subcombination, range, or subrange thereof, although one of ordinary skill in the art will recognize that other ranges are within the scope of the present invention.

[0052] Thus, each of the at least one liquid branched alkane or liquid linear alkane in the makeup remover composition may be present in an amount of from about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 128, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 to about 35 weight percent, including increments and ranges therebetween, calculated on the total weight of the makeup remover composition.

[0053] (ii) Emollient ester

[0054] In accordance with the present disclosure, makeup remover compositions include at least one emollient ester, which in some embodiments includes a branched alkylated alcohol ester.

[0055] In some embodiments, suitable emollient esters that can be used in accordance with the present disclosure may be selected from isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate, methyl palmitate, 2-ethylhexyl palmitate, hexyl laurate, ethylhexyl laurate, isopropyl laurate, ethylhexyl oleate, ethylhexyl isononanoate, isononyl isononanoate, myristyl myristate, 2-ethylhexyl caprate / caprylate (or octyl caprate / caprylate), isostearyl neopentanoate, cetearyl ethylhexanoate, isopropyl isostearate, diisopropyl sebacate, coco-caprylate / caprate, diisopropyl adipate, and combinations thereof, as well as esters of lactic acid with fatty alcohols containing 12 or 13 carbon atoms and combinations thereof.

[0056] In some particular embodiments, the at least one emollient ester comprises isopropyl myristate.

[0057] In some embodiments, the one or more emollient esters are present in an amount of from about 1% to about 8% by weight, calculated by weight of the makeup remover composition.

[0058] In some embodiments, the one or more emollient esters include isopropyl myristate present at about 1% to about 8% by weight, calculated by weight of the makeup remover composition.

[0059] In some embodiments, the total amount of emollient esters does not exceed about 10% total by weight of the makeup remover composition.

[0060] In some embodiments, the makeup remover composition comprises two or more emollient esters. In some such embodiments, at least one emollient ester comprises isopropyl myristate and one or more additional emollient esters. In some particular embodiments, the makeup remover composition comprises isopropyl myristate, isopropyl palmitate, and ethylhexyl palmitate.

[0061] According to various embodiments, each of the at least one emollient esters, calculated by weight of the makeup remover composition, is present in an amount of about 0.1% to about 15%, about 1% to about 10%, about 1% to about 8%, or about 1% by weight of the makeup remover composition, or any suitable combination, subcombination, range, or subrange thereof. The total amount of emollient esters present in the makeup remover composition, calculated by weight of the makeup remover composition, is in the range of about 0.1% to about 15%, or about 1% to about 8% by weight, or any suitable combination, subcombination, range, or subrange thereof. However, one of ordinary skill in the art will recognize that other ranges are within the scope of the present invention.

[0062] Thus, each of the at least one emollient ester in the makeup remover composition may be present in about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 to about 15 weight percent (including increments and ranges therein and therebetween), calculated on the total weight of the makeup remover composition.

[0063] (iii) polymer

[0064] In various embodiments, the makeup remover composition comprises at least one polymer, hi some embodiments, the at least one polymer is selected from the group consisting of cellulose, gum, hydrophilic colloid, and combinations thereof.

[0065] Polymers include nonionic, anionic, cationic and amphoteric polymers such as chitosan, chitin, starch, alginates, cellulose, galactomannans (including, for example, guar gum and its derivatives, hydroxypropyl guar, cationic guar derivatives), gums of microbial origin (including xanthan gum, scleroglucan gum, mucopolysaccharides, chondroitin sulfate and mixtures thereof), gums derived from plant exudates (including locust bean gum, gum arabic, gum ghatti, gum karaya, tragacanth gum, carrageenan gum, agar gum and carob gum), cellulosic polymers (methylcellulose, hydroxyalkylcellulose, ethyl hydroxypropyl cellulose, methyl ... The polysaccharides may be selected from the group consisting of polysaccharides such as cellulose ether derivatives, hydroxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, cationic cellulose ether derivatives, quaternized cellulose derivatives, nitrocellulose, hemicellulose and hemicellulose derivatives), mannan, xylan, lignin, araban, galacturonan, alginate-containing compounds, glucuronoxylan, arabinoxylan, xyloglucan, glucomannan, fructosans (e.g., inulin), pectic acid and pectin, arabinogalactan, agar, glycosaminoglycans, gelatin, gellan, cross-linked homopolymers of acrylic acid, and combinations thereof.

[0066] In some particular embodiments, the makeup remover composition comprises at least one polymer comprising hydroxyethyl cellulose, hi some embodiments, the makeup remover composition excludes thickeners comprising xanthan gum.

[0067] In some embodiments, the at least one polymeric thickener for aqueous systems is present in an amount of from about 0.01% to about 1.0% by weight, calculated on the weight of the makeup remover composition.

[0068] In some embodiments, the at least one polymeric thickener for aqueous systems comprises hydroxyethyl cellulose.

[0069] The at least one polymer is present in the makeup remover compositions according to the present disclosure in an amount, calculated by weight of the makeup remover composition, of from about 0.01% to about 10%, from about 0.01% to about 5%, from about 0.01% to about 1%, from about 0.0% to about 0.03%, or about 0.025% by weight, or any suitable combination, subcombination, range, or subrange thereof.

[0070] Thus, one polymer or combination of polymers may be present in about 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9 to about 10 weight percent (including increments and ranges therebetween), calculated on the total weight of the makeup remover composition.

[0071] (iv) Polyglyceryl nonionic surfactants

[0072] According to various embodiments, the makeup remover composition comprises at least one polyglyceryl nonionic surfactant. In some embodiments, the at least one nonionic surfactant may be selected from a polyglyceryl nonionic surfactant selected from the group consisting of polyglyceryl esters, polyglyceryl ethers, polyglyceryl sorbitan fatty acid esters, combinations of two or more thereof, etc. In some embodiments, the at least one nonionic surfactant is selected from polyglyceryl esters, polyglyceryl ethers, and combinations of two or more thereof.

[0073] In some embodiments, the at least one nonionic surfactant is selected from the group consisting of polyglyceryl-4 caprylic / caprate, polyglyceryl-5 caprylic / caprate, polyglyceryl-6 caprylic / caprate, polyglyceryl-7 caprylic / caprate, polyglyceryl-8 caprylic / caprate, polyglyceryl-9 caprylic / caprate, polyglyceryl-10 caprylic / caprate, polyglyceryl- 4, Polyglyceryl-5 Caprate, Polyglyceryl-6 Caprate, Polyglyceryl-7 Caprate, Polyglyceryl-8 Caprate, Polyglyceryl-9 Caprate, Polyglyceryl-10 Caprate, Polyglyceryl-4 Laurate, Polyglyceryl-5 Laurate, Polyglyceryl-6 Laurate, Polyglyceryl-7 Laurate, Polyglyceryl-8 Laurate, Polyglyceryl-9 Laurate, Polyglyceryl Laurate Polyglyceryl-10, Polyglyceryl-6 Cocoate, Polyglyceryl-7 Cocoate, Polyglyceryl-8 Cocoate, Polyglyceryl-9 Cocoate, Polyglyceryl-10 Cocoate, Polyglyceryl-11 Cocoate, Polyglyceryl-12 Cocoate, Polyglyceryl-6 Myristate, Polyglyceryl-7 Myristate, Polyglyceryl-8 Myristate, Polyglyceryl-9 Myristate, Polyglyceryl Myristate

[0033] In one embodiment, the surfactant is selected from polyglyceryl nonionic surfactants, which may be selected from the group consisting of polyglyceryl-10 myristate, polyglyceryl-11 myristate, polyglyceryl-12 myristate, polyglyceryl-10 oleate, polyglyceryl-11 oleate, polyglyceryl-12 oleate, polyglyceryl-10 stearate, polyglyceryl-11 stearate, polyglyceryl-12 stearate, and combinations of two or more thereof.

[0074] In some embodiments, the at least one nonionic surfactant is selected from the group consisting of polyglyceryl-2 oleate, polyglyceryl-4 caprylic / caprate, polyglyceryl-5 caprylic / caprate, polyglyceryl-6 dicaprate, polyglyceryl-6 caprylic / caprate, polyglyceryl-7 caprylic / caprate, polyglyceryl-8 caprylic / caprate, polyglyceryl-9 caprylic / caprate, caprylic Acid / Polyglyceryl-10 Caprate, Polyglyceryl-4 Caprate, Polyglyceryl-5 Caprate, Polyglyceryl-6 Caprate, Polyglyceryl-7 Caprate, Polyglyceryl-8 Caprate, Polyglyceryl-9 Caprate, Polyglyceryl-10 Caprate, Polyglyceryl-4 Laurate, Polyglyceryl-5 Laurate, Polyglyceryl-6 Laurate, Polyglyceryl-7 Laurate Polyglyceryl-8, Polyglyceryl-9 Laurate, Polyglyceryl-10 Laurate, Polyglyceryl-6 Cocoate, Polyglyceryl-7 Cocoate, Polyglyceryl-8 Cocoate, Polyglyceryl-9 Cocoate, Polyglyceryl-10 Cocoate, Polyglyceryl-11 Cocoate, Polyglyceryl-12 Cocoate, Polyglyceryl-6 Myristate, Polyglyceryl-7 Myristate, Polyglyceryl Myristate The glyceryl-8 myristate, polyglyceryl-9 myristate, polyglyceryl-10 myristate, polyglyceryl-11 myristate, polyglyceryl-12 myristate, polyglyceryl-10 oleate, polyglyceryl-11 oleate, polyglyceryl-12 oleate, polyglyceryl-10 stearate, polyglyceryl-11 stearate, polyglyceryl-12 stearate, and combinations of two or more thereof.

[0075] In some embodiments, the makeup remover composition comprises one nonionic surfactant. In some embodiments, the makeup remover composition comprises at least two or more nonionic surfactants.

[0076] In some embodiments, the makeup remover composition comprises polyglyceryl-6 caprylate and polyglyceryl dicaprate.

[0077] In some embodiments, the at least one polyglyceryl nonionic surfactant is present in a total amount of from about 0.01% to about 0.2% by weight, calculated by weight of the makeup remover composition.

[0078] In some embodiments, the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate present at about 0.025% by weight and polyglyceryl dicaprate present at about 0.025% by weight, calculated by weight of the composition.

[0079] In some embodiments, each of the at least one nonionic surfactant in the makeup remover composition is present, calculated by weight of the makeup remover composition, from about 0.01 wt. % to about 1 wt. %, from about 0.01 wt. % to about 0.2 wt. %, or from about 0.02 wt. % to about 0.03 wt. %, or any suitable combination, subcombination, range, or subrange thereof, although one of ordinary skill in the art will recognize that other ranges are within the scope of the present invention.

[0080] Thus, each of the at least one nonionic surfactant is present in an amount of from about 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 to about 1.0 weight percent, including increments and ranges therebetween, calculated on the total weight of the makeup remover composition.

[0081] (v) water

[0082] According to various embodiments, water, calculated by weight of the makeup remover composition, is present in the makeup remover composition in a range of about 30% to about 70% by weight, about 35% to about 65% by weight, about 40% to about 60% by weight, about 45% to about 55% by weight, or about 50% by weight, or any suitable combination, subcombination, range, or subrange thereof. However, one of ordinary skill in the art will recognize that other ranges are within the scope of the present invention. Thus, water, calculated by the total weight of the makeup remover composition, is present in an amount of about 30, 35, 40, 45, 50, 55, 60, 65, to about 70 weight percent, including increments and ranges therein.

[0083] The water used may be sterilized demineralized water and / or floral waters such as rose water, cornflower water, chamomile water or lime water, and / or natural spring or mineral waters such as Vittel water, Vichy Basin water, Uriage water, La Roche-Posay water, La Bourboule water, Enghien-les-Bains water, Saint-Gervais-les-Bains water, Néris-les-Bains water, Albard-les-Bains water, Digne water, Mézières water, Nérac-les-Bains water, Lons-le-Saunier water, Eau-Bonnes water, Rochefort water, Saint-Christophe water, Les Fumades water, Tercy-les-Bains water or Avène water. The aqueous phase may also contain reconstituted spring water, i.e. water containing trace elements such as zinc, copper and magnesium that reconstitute the characteristics of thermal water.

[0084] The pH of the makeup remover composition is generally, but not limited to, 2 to 12, and in some embodiments, one of 3 to 11, 5 to 9, and 6 to 8, and in some embodiments, 7. In some particular embodiments, the pH of the makeup remover composition ranges from a pH of about 4 to a pH of about 7. The pH is adjusted to the desired value by adding to the makeup remover composition a base (organic or inorganic), such as ammonia or a primary (poly)amine, secondary (poly)amine, or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, or 1,3-propanediamine, or by adding an inorganic or organic acid, advantageously a carboxylic acid, such as citric acid.

[0085] In some embodiments, the makeup remover composition excludes alcohols, for example, monoalcohols such as ethanol, propanol, butanol, isopropanol, isobutanol, and monohydric C1-C8 alcohols such as benzyl alcohol and phenylethyl alcohol.

[0086] Optional ingredients

[0087] In some embodiments, in accordance with the present disclosure, one or more active agents may be present in the cosmetic composition, and additives may include, for example, preservatives / antimicrobials (e.g., chlorphenesin, salicylic acid, phenoxyethanol, potassium sorbate, and caprylyl glycol), active agents (e.g., hydroxyacetophenone), vitamins (e.g., vitamin A, beta-carotene, tocopherol / vitamin E, panthenol, retinol, resveratrol, vitamin C, niacinamide, derivatives thereof, and combinations thereof), hyaluronic acid in the form of hydrolyzed hyaluronic acid or sodium hyaluronate. Acetaminophen, colorants / pigments, essential oils, antioxidants (chalcones, flavones, flavanones, flavanols, flavonols, dihydroflavonols, isoflavonoids, neoflavonoids, catechins, anthocyanidins, tannins, lignans, aurones, stilbenoids, curcuminoids, alkylphenols, betacyanins, capsacinoids, hydroxybenzoketones, methoxyphenols, naphthoquinones, phenolic terpenes, resveratrol, curcumin, pinoresinol, ferulic acid, hydroxytyrosol, cinnamic acid, caffeic acid, p-coumaric acid, baicalin (Scutellaria bis(trimethylsiloxy)phenylalanine)). Baicalensis root extract), pine bark extract (Pinus mariana bark / bud extract), phenolic compounds such as ellagic acid), vitamins and vitamin derivatives such as calcium pantothenate, tocopherol, ascorbic acid, hydroxy acids, citric acid, sodium citrate, sodium chloride, neutralizing agents, chelating agents or pH adjusters (e.g., triethylamine (TEA), trisodium ethylenediaminedisuccinate, EDTA and sodium hydroxide), powders, fragrances, dyes, pigments, organic or mineral UV filters, and combinations thereof.

[0088] In some particular embodiments, compositions according to the present disclosure may include one or a combination of additives selected from sodium hydroxide, panthenol, hydroxyacetophenone, gluconolactone, myrtrimonium bromide, sodium citrate, sodium chloride, dicaprylyl ether, citric acid, or combinations thereof.

[0089] It will be understood that the optional ingredients mentioned above are provided as examples, and that other optional ingredients compatible with cosmetic applications known in the art may be used.

[0090] According to various embodiments, the amount of one or more active agents and additives, when present in the compositions of the present disclosure, alone or in combination, calculated on the total weight of the composition, may be present in a range from about 0.0001% to about 20% by weight, in some embodiments from about 0.005% to about 0.01% by weight, in some embodiments from about 0.01% to about 0.1% by weight, in some embodiments from about 0.15% to about 5% by weight, in some embodiments from about 0.40% to about 4% by weight, in some embodiments from about 0.5% to about 2.5% by weight, in some embodiments from about 0.1% to about 0.5% by weight, in some embodiments from about 1% to about 2% by weight, or any suitable combination, subcombination, range, or subrange thereof. However, one of ordinary skill in the art will recognize that other ranges are within the scope of the present invention.

[0091] Thus, any one or combination of active agents and additives may be present, and any one or combination thereof may each be present in an amount of about 0.0001, 0.0005, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04 , 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent (including increments and ranges therebetween).

[0092] Products / manufactured goods

[0093] The present invention also relates to a cosmetic product comprising the makeup remover composition of the present invention. The product of the present invention comprises the makeup remover composition of the present invention and a container or wrapper in which the makeup remover composition is contained.

[0094] The makeup remover compositions of the present invention are sprayable, i.e., capable of being dispensed in the form of fine particles or a mist, meaning that they are contained and dispensed using a dispenser equipped with a spray nozzle, which in some embodiments is a high-definition spray nozzle capable of delivering a mist having particles (droplets) on the micron scale ranging from about 10 microns to about 900 microns, or from about 40 microns to about 300 microns, or having an average size of about 80 to about 100 microns.

[0095] Thus, the present invention also relates to a product comprising a container and a spray nozzle, said container containing the makeup remover composition of the present invention.

[0096] The makeup remover compositions of the present invention can be applied to any container equipped with a spraying means, including suitable aerosol, most preferably non-aerosol, spray devices. Thus, non-aerosol spray devices are preferred, including mist or spray pumps such as Eurogel Spray Pump (available from Seqquist Perfect, Cary Ill.), PI Spray Pump (available from Precision, Ajax, Canada), APTAR oil mist pump, [Rare Beauty] spray pump, Calmar Spray Pumps, Calmar, Inc., City of Industry, Calif., and Mitani Mist Pumps (available from MITANI VALVE CO., LTD.).

[0097] In one particular embodiment of the present invention, the present disclosure provides a product comprising: a container containing a makeup remover composition according to the present invention; an outlet, such as a spray nozzle, connected to the container; and a spray device capable of releasing the makeup remover composition from the container through the outlet, the spray nozzle being a fine mist nozzle capable of delivering a pump volume of about 0.02 ml (ranging from about 0.01 to about 1.0 ml per pump) of mist and having particles (droplets) with an average size of about 80 to about 100 microns, such as micron-scale particles ranging from about 10 microns to about 900 microns, or from about 40 microns to about 300 microns. In some such embodiments, the makeup remover composition contained in the container is transparent or translucent, the term "translucent" referring to the property of a material that transmits light without permitting the identification of alphanumeric characters using a sample 5 mm thick; and "transparent" referring to the property of a material that transmits light and permits the identification of alphanumeric characters using a sample 5 mm thick. In some particular embodiments, the mist droplets are also translucent or transparent.

[0098] The following examples according to the invention are given by way of illustration and not of a limiting nature. The names are chemical names or INCI names. Unless otherwise stated, the amounts are given as % by weight. [Example]

[0099] Example 1: Raw materials [Table 1]

[0100] Example 2: Composition of the Invention Various representative embodiments of the compositions of the present invention are illustrated herein.

[0101] [Table 2]

[0102] [Table 3]

[0103] [Table 4]

[0104] Example 3: Comparative Composition #1 [Table 5]

[0105] [Table 6]

[0106] [Table 7]

[0107] [Table 8]

[0108] [Table 9]

[0109] [Table 10]

[0110] Example 4: Demonstration of spray and sensory properties of various water-to-oil ratios of the present invention [Table 11]

[0111] Example 5: Demonstration of makeup removal by varying the water to oil ratio [Table 12]

[0112] Example 6: Stability Demonstration [Table 13]

[0113] Example 7: Osmolality Test [Table 14]

[0114] The osmolality of the aqueous phase of Var 9 was tested, which further contained coloring agents, fragrances, and 0.02% hydroxyethylcellulose. Briefly, the equipment used included an automatic osmometer OSK 40BU201 (Ogawa-seiki), and the protocol for the test included preparing the composition, shaking it 20 times and leaving it to stand for at least 8 hours (e.g., overnight), extracting the aqueous phase, and measuring the osmolality (the score is expressed in mOsm / l, or molecules per liter of test material) using the osmometer.

[0115] Thus, there is a close transitional relationship between the tested composition and Var 9 and INV 1 (both of which differ only in oil / water concentration). It is understood in the art that osmolality can be used as an indirect means to assess whether a formulation may be irritating to the eyes, based on the understanding that tear fluid osmolality values ​​range from 260 to 290, and that the closer a product's osmolality (mOsm / L) is to this range, the more gentle it is to the eyes. Therefore, since the value of 315 mOsm / L is close to that of tear fluid, it can be empirically concluded that the listed formulation is suitable as a makeup remover for use around the eyes without causing discomfort. These results are supported by clinical studies, demonstrating that no subjects reported any skin or eye irritation. According to various embodiments, the osmolality ranges from about 260 to about 350 mOsm / L, and in some embodiments, from about 300 to about 330 mOsm / L.

[0116] While consumer testing has demonstrated that the compositions of the present invention are generally non-irritating to the skin and eyes, this osmolality test is more specific in that it indicates eye-friendliness, an important part of the makeup removal process.

[0117] Example 8: CMC Surface Tension Test Var 9 of the present invention was used to evaluate the critical micelle concentration, demonstrating the concentration of surfactant in the bulk phase. Above this concentration, micelles, which are aggregates of surfactant molecules, begin to form. CMC surface tension measurements were performed using a tensiometer. Referring now to Figure 1, the curve shows the decreasing slope of the surface tension before plateauing and the surface tension becoming constant. The intersection of the decreasing slope and the surface tension plateau indicates the presence of micelles. The shape of the curve demonstrates that the aqueous phase of the tested invention 1 is micellar.

[0118] Example 9: In vitro study: Evaluating the effect of makeup remover dissolving mist spray on skin barrier function in vitro using biophysical tests and a zein protein model The purpose of this experiment was to demonstrate the effect of makeup removers on the lipids and proteins of the stratum corneum (SC) and to demonstrate the effect of different formulation compositions, i.e., surfactants, humectants, etc., on the mildness potential of the cleanser.

[0119] This study also demonstrated how the composition of the present invention (INV 1) performed with respect to DSC, TEWL and Zein tests.

[0120] An in vitro evaluation of the mildness of makeup remover dissolving mist spray INV 1 was conducted. Overall, INV 1 fell within the target mildness zone (roughly defined by the pale green rectangle) where it neither perturbed lipids (DSC) nor increased water loss (TEWL).

[0121] Water vapor permeation through SC (in vitro TEWL) The surface of the SC sample was cleaned with isooctane and placed in a TEWL sample holder. The sample holder was then immersed in Evian water to wet the SC and allowed to dry in ambient air for at least 1 hour. The surface of the SC sample was pre-wetted with a solution of a water and n-propanol mixture (8:2) at 10 μl per sample and then conditioned for 8 hours in a glove box under controlled atmosphere (30°C, 30% RH). A control TEWL measurement (T0) was recorded. The SC sample was then immersed in a cleanser formulation diluted 4:1 with water (25%) for 2 hours with gentle agitation on a shaker, rinsed with three successive water washes, and the sample was left to dry at room temperature for at least 4 hours. The SC sample was then placed in a temperature-humidity controlled chamber equilibrated at 30°C and 30% RH. After overnight equilibration, a TEWL measurement (T1) was recorded.

[0122] Water flow across SC samples positioned above a water tank was measured. Measurements were performed in a glove box maintained at 30°C and 30% RH using a humidity probe coupled to a robotic sample holder and a Dermalab data acquisition system. The humidity probe contains two humidity sensors positioned at different heights within a cylindrical probe chamber, which measures humidity gradients and can be used to calculate water vapor flow. Measurements were performed before and after each sample treatment, ensuring each sample served as its own control and ensuring robust measurements.

[0123] Reference is now made to Figure 2 and Table 15, which show the results of the following tests. Due to the high variability inherent in SC substrates, the results are expressed as the relative variation in TEWL for all samples: Δ(TEWL) = (T1 - T0) / T0 100%. Positive variations correspond to a diffusion effect (weakening of the barrier function), while negative values ​​correspond to an occlusive effect. The mean values ​​are shown as open boxes for reference.

[0124] Assessment of intercellular SC lipid perturbations by DSC After TEWL measurements, the same samples were equilibrated at 75% RH and 25°C for another 4 h before being used for DSC analysis.

[0125] The DSC pan was placed on an analytical balance and the weight was tared. The SC sample was removed from the glove box / temperature and humidity chamber and the sample removed from the sample holder. Two SCs were rolled together and placed in a tared DSC pan and sealed using a crimper press. The weight of the DSC pan was recorded and submitted for DSC analysis.

[0126] Measurements were carried out in a sealed aluminum pan by heating from 10°C to 110°C at a rate of 5°C / min.

[0127] Reference is now made to Figure 2 and Table 15, which show the results of the following studies. A linear combination of the measured shifts in the T2 and T3 transitions for each treatment was used as a measure of SC lipid disturbance after treatment: ΔT 効果 =0.7 ΔT m (T2)+0.3 ΔT m (T2). The T2 transition was given higher weight because it was the main criterion for lipid perturbation with well-established interpretation, while the contribution of T3 was also included.

[0128] Assessing protein solubilization by the zein test The zein solubility test was used to evaluate the harshness of surfactants. Zein, a yellow corn protein similar to the keratin present in skin, which has limited solubility in water, was denatured (solubilized) by the surfactant. The ability of surfactants to denature and solubilize zein correlates with their skin irritation potential. Soluble zein protein was measured using a modified Lowry method using a spectrophotometer. Absorbance correlates with zein protein solubility, which can then be considered a measure of a product's irritation potential or harshness. The harshness of the analyzed samples was graded and compared using a 1.5% solution of sodium laurate sulfate (SLS) as a positive control. Sample harshness data is expressed as a percentage of the SLS score.

[0129] The calculated % zein scores for each blank are shown in Table 15 below. The ranking of the samples based on their analyzed harshness (% zein score) relative to SLS is shown in Figure 2. Referring now to Figure 2, the plot shows that zein score is a function of DSC and TEWL scores, as explained hereinabove. Invention 1 had a zein score of 48, which is just below the peak of severe protein denaturation, i.e., within the upper right-hand range of the illustrated rectangle, and is within the range considered to be a mild formulation. Compositions according to the present disclosure have zein scores ranging from about 88 to about 13, which is achieved by using surfactants according to the present disclosure and avoiding harsh surfactants that cause lipid dissociation and high zein solubilization.

[0130] Mapping cleansers through three mildness tests The results of the above three tests (TEWL, DSC, and zein) can be conveniently combined into a single mapping to visually represent the performance of each formulation according to these tree criteria. In the mapping below, the abscissa indicates the effect on barrier properties related to water penetration (TEWL), and the ordinate indicates the effect on lipid ordering (DSC). The light green rectangle corresponds to the target hypoallergenic region where neither SC permeabilization nor lipid disorder occurs. Zein scores are represented by the color of the data points, with red shading indicating a high score (strong protein solubilization / denaturation) and green shading indicating a low score (less protein solubilization / denaturation).

[0131] [Table 15]

[0132] Example 10: Clinical Study: Study A A clinical study was conducted comparing the present invention to a commercially available benchmark product, as well as other commercially available spray and non-spray makeup removers.

[0133] In Clinical Study A, COMP 1 glides on smoothly, dissolving all cosmetics immediately upon contact, leaving a long-lasting mist that leaves skin feeling smooth and dry without any tightness or dryness. This leak-proof, ultra-fine mist is COMP 1's secret to easily removing full-on makeup. The formula soothes skin with soothing jojoba oil and brightening rosehip oil, and refreshes with the fragrance of green tea, cucumber, and rose. The inventive compositions herein were evaluated against this competitive benchmark product.

[0134] Methodology · Blinded, sequential monadic design · Two products · INV 1 · COMP 1 · Online recruitment and in-person placement · Online survey and video for each product after 5 days of use

[0135] Inclusion Criteria · N = 37, female · Ages 18-55 · Currently using makeup remover at least 5 days a week - any form · Cannot use makeup remover wipes alone · Must use waterproof mascara (can use both types, but can wear waterproof for 10 days), long-wear foundation and / or lipstick · Can use spray-on makeup remover · Mass market and / or luxury market users · All skin types: oily, dry, normal, combination · All skin tones · All ethnicities · Standard safety screening

[0136] Exclusions: ·Those who only use wipes to remove makeup ·Those with known skin or cosmetic allergies or sensitivities ·Those currently receiving specialist facial dermatological treatment ·Those with very / extremely sensitive skin and eyes ·Those prone to severe acne ·Those who have had facial surgery within the past 3 months ·Pregnant or breastfeeding

[0137] Tested subjects: INV 1 vs COMP 1. Referring to Figure 3, this chart details the consumer sensory journey and reported overall perception based on testing conducted in the clinical study, with specific data points listed in Table 16.

[0138] Referring again to Figure 3, it should be noted that these compositions differ significantly in the amount and nature of the oil content, with COMP 1 being anhydrous and containing silicone oil / silicone and a strong surfactant, and INV 1 demonstrating an overall favorable application experience with the opportunity to improve the level of scrubbing required for complete removal. COMP 1 had a similar pre- and in-use experience to INV 1. However, COMP 1 was less favorable after use, with a clean feel and no residue left behind, and was less rated for the unusual need to wash the face after application.

[0139] As shown, INV 1 outperforms COMP 1 in terms of product consistency and also demonstrates a significant advantage in after-use feel. Consumers preferred the inventive formulation INV 1 over the top benchmark product COMP 1 due to its clean appearance, pleasant feel (no need to wash face after use), and gentleness to the face.

[0140] Both products were rated by users as effective, gentle on the skin, and providing a fast removal process. Notably, while the overall performance of the present invention and the comparative example proved comparable, the major advantage of the present invention is the surprisingly effective removal with an aqueous composition that does not require rinsing after use and does not leave a greasy, oily feeling on the skin.

[0141] [Table 16] TIFF2025537380000018.tif100159

[0142] Example 11: Clinical Study B: Mascara Removal, Evaluation of Removal Efficacy COMP 1 and INV 1 were evaluated. Subjects: N=18 volunteers, Caucasian women, ages 18-60, with medium to long eyelashes and non-droopy eyelids. Test product: Maybelline Colossal Big Shot Very Black Waterproof Mascara.

[0143] Cosmetics were applied identically to all subjects according to a standardized procedure, including pre-washing. Mascara removal was performed by the same standardized procedure for all subjects.

[0144] References to Invention 1 in this example include the same formulation in specific packaging (SP).

[0145] The different applicators resulted in very different experiences for the volunteers. COMP 1 (aerosol spray) was a lightweight mist that appeared to have nothing on the face. In some cases, volunteers thought they were getting nothing on at all. INV 1 had a more moisturizing effect upon application. Subjects could feel the product on their face, indicating it was being dispensed onto the skin.

[0146] Dry hand emulsification is key to making spray removers work best. Initial circular movements around the lashes immediately showed the product breaking down. COMP 1 spray deteriorated a little faster due to its higher oil content. Both products were reported to look and feel different on the skin. COMP 1 gave an oily feel / appearance on the face, and the broad mist left oil particles around the hairline, making hair look greasy (though consumers may or may not have found this acceptable). INV 1 had a very wet appearance upon application, broke down easily during emulsification, and was generally easy to remove. The product itself was not very slippery, so there was only slight resistance to removal with a round cotton ball (not felt by consumers).

[0147] Overall, both makeup remover sprays fall into the highly efficient category when emulsified with dry hands. COMP 1 performed slightly better than the market leader COMP 2. INV 1 performed similarly to COMP 2 and COMP 3. While the removal methods differ in the two-phase & spray Galen formulations, overall, both products are very efficient waterproof mascara removers.

[0148] [Table 17]

[0149] Example 12: Clinical Study C: Mascara Removal, Evaluation of Removal Efficacy A study was conducted to demonstrate the performance of the new packaging option for INV 1. Subjects: N=6 volunteers, Caucasian women, ages 18-60, with medium-to-long eyelashes and non-droopy eyelids. Test products: Maybelline Colossal Big Shot Very Black Waterproof Mascara in INV 1, INV 1 CP, and COMP 1-7.

[0150] Reference to Invention 1 in this example includes the same formulation in different packaging (SP and CP).

[0151] Cosmetics were applied identically to all subjects according to a standardized procedure, including pre-washing. Mascara removal was performed by the same standardized procedure for all subjects.

[0152] Conclusions: Overall, the INV 1, which uses a similar sprayer to the Inv 8, has significantly lower removal efficacy when compared to the original prototype makeup remover, INV 1 CP. While the original prototype is a highly efficient stubborn mascara remover, the modified pump INV 1 reduces efficiency to the moderate category. While the formula is the same, the impact of how much product is dispensed onto the target area is different. The INV 1 pump sprays everywhere around the face but not close enough to the eye area for proper saturation for removal, resulting in lower efficacy. Both the competitor makeup remover sprayers, Inv 5 and Inv 6, function as moderately efficient stubborn mascara removers. Inv 8 is slightly more efficient than Inv 7, by a difference of one round cotton ball (median).

[0153] [Table 18]

[0154] Example 13: Clinical Study D: Mascara Removal, Evaluation of Removal Efficacy

[0155] A study was conducted to demonstrate the performance of new packaging options for INV 1 with different applicators (CP, HDM, and OP). Subjects: N=6 volunteers, Caucasian female, ages 18-60, with medium-to-long eyelashes and non-droopy eyelids. Test products: INV 1, INV 1 CP, INV 1 HDM, INV1 OP, COMP 1-7.

[0156] Reference to Invention 1 in this example includes the same formulation in different packaging (SP, CP, HDM and OM).

[0157] Cosmetics were applied identically to all subjects according to a standardized procedure, including pre-washing. Mascara removal was performed by the same standardized procedure for all subjects.

[0158] Overall, both makeup remover sprays fall into the highly efficient category when emulsified with dry hands. COMP 1 performed slightly better than the market-leading makeup remover Comp 2. The two formulations tested (INV 1 HDM & INV 1 OM) performed similarly to the two-phase products Comp 2 & Comp 3. While the removal method differs for the two-phase & spray Galen formulations, overall, both products are very efficient waterproof mascara removers.

[0159] [Table 19]

[0160] These results provide evidence that the fine mist spray packaging produces high efficacy in a two-phase water / oil composition in the same category as a competitive 100% oil composition (COMP 1).

[0161] Example 14: Clinical Study E: Evaluation of a mist spray pump container of the present invention (INV 1) vs. a reference product aerosol (COMP 1) (propellant-based) spray The study was conducted to explore consumer perceptions and preferences towards the formulation and packaging by assessing the entire product journey, including product application, texture, feel, final appearance, application sensation and removal.

[0162] Methods: A 14-day home use study was conducted in two consumer markets using a randomized sequential monadic design. 42 female users of mass and premium brand cosmetics, aged 18-30 years, representing a mix of ethnicities, skin types, and skin tones, used INV1 and COMP1 products on four active days. Participants were provided with a product use protocol, including specific instructions for product application, makeup and mascara removal, and completed questionnaires regarding product application and sensory experience.

[0163] The results are provided in Table 20 below.

[0164] Tested: INV 1 vs COMP 1. Referring to Figure 4, this chart details the consumer journey using the INV 1 dispensing mist pump and the COMP 1 aerosol spray.

[0165] Referring again to Figure 4, it should be noted that these compositions differ significantly in terms of the amount and nature of the oil content, with COMP 1 being anhydrous and containing silicone oil / silicone and strong surfactants, and INV 1 being mist pump dispensed, demonstrating an overall favorable user experience, although both products demonstrate room for improvement with regard to direct application to the face and initial oiliness felt on the skin.

[0166] Both products were rated by users as effective, gentle on the skin, and providing a rapid removal process. Notably, the overall performance of the inventive and comparative dispensers proved comparable, with the main advantage of the present invention being the elimination of aerosol propellants and the overall reduction in silicone and surfactant usage, without compromising efficacy.

[0167] [Table 20] TIFF2025537380000023.tif42159

[0168] While the present disclosure has been described with reference to preferred embodiments, those skilled in the art will recognize that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the disclosure. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the disclosure without departing from the essential scope thereof. Therefore, it is not intended that the disclosure be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this disclosure, but rather, it is intended to include all embodiments falling within the scope of the appended claims.

[0169] The articles "a" and "an," as used herein, mean one or more when applied to any feature in the embodiments of the present disclosure described herein and in the claims. The use of "a" and "an" does not limit the meaning to a single feature unless specifically stated to do so. The article "the" before singular or plural nouns or noun phrases indicates a specific designated feature and may have a singular or plural meaning depending on the context of use. The adjective "any" means one, some, or all of any quantity indiscriminately.

[0170] "At least one," as used herein, means one or more, and therefore includes individual components and mixtures / combinations.

[0171] The transitional terms "comprising," "consisting essentially of," and "consisting of," in their original and modified forms, when used in the appended claims, define the scope of the claim with respect to additional, unrecited claim elements or steps, if any, that are excluded from the scope of the claim(s). The term "comprising" is intended to be inclusive or open-ended and does not exclude additional, unrecited elements, methods, steps, or materials. The term "consisting of" excludes elements, steps, or materials other than those recited in the claim, and in the latter case, impurities normally associated with the specified material(s). The term "consisting essentially of" limits the scope of the claim to the specified element, step, or material(s) and those that do not materially affect the basic novel feature(s) of the claimed disclosure. All materials and methods described herein embodying the present disclosure may, in alternative embodiments, be more specifically defined by any of the transitional terms "comprising," "essentially consisting of," and "consisting of."

[0172] In some embodiments, the terms "exclude," "free," and "essentially free" mean that the makeup remover composition does not contain any reliably measurable excluded substances, typically 0% by weight, calculated based on the total weight of the makeup remover composition, or, for example, greater than about 5% by weight, calculated based on the total weight of the makeup remover composition, of any of the excluded substances described herein. The terms "exclude," "free," and "essentially free" mean that the makeup remover composition preferably contains no excluded substances, but that the makeup remover compositions of the present invention can contain trace amounts of the excluded substances (as long as these amounts do not substantially affect the beneficial properties of the makeup remover composition). In particular, the terms "exclude," "free," and "essentially free" mean that the material can be present in the makeup remover composition at less than 5% by weight, less than 4% by weight, less than 3% by weight, less than 2% by weight, less than 1% by weight, or less than 0.1% by weight, calculated based on the total weight of the makeup remover composition. According to various embodiments, it is contemplated that some or all of the following ingredients may be excluded from the makeup remover compositions of the present invention: alcohol (e.g., including, but not limited to, monohydric alcohols), nylon-12, polymethylmethacrylate, polyethylene beads and powders considered to be microplastics, lactic acid, glycolic acid, tartaric acid, mandelic acid, citric acid, salicylic acid and derivatives thereof (including 5-n-octanoyl salicylic acid, salicylates, sodium salicylate, and willow extract), capryloyl salicylic acid, beta-hydroxybutyric acid, propionic acid, beta-hydroxybeta-methylbutyric acid. , carnitine tropic acid and trethocanic acid, alkyl polyglucosides selected from the group consisting of decyl glucoside, lauryl glucoside, octyl glucoside, coco glucoside, caprylyl / capryl glucoside and sodium lauryl glucose carboxylate, and combinations thereof, surfactants having a C10-C20 fatty alcohol or acidic hydrophobic group condensed with about 2 to about 100 moles of ethylene oxide or propylene oxide per mole of hydrophobic group, C2-C10 alkylphenol condensed with 2 to 20 moles of alkylene oxide, mono- and di-fatty acid esters of ethylene glycol,Fatty acid monoglycerides, sorbitan, mono- and di-C8-C20 fatty acids, polyoxyethylene sorbitan, alkyl polyglycosides and sugar fatty amides (e.g., methyl gluconamide), alkyl ether sulfates and sulfonates, alkyl sulfates and sulfonates, alkyl benzene sulfonates, alkyl and dialkyl sulfosuccinates, C8-C20 acyl isethionates, C8-C20 alkyl ether phosphates, alkyl ether carboxylates, PEG-100 stearates, PEG-20 stearates and other polyesters (ethylene glycol), polyethylene glycol (PEG) surfactants, polypropylene glycol (PPG) surfactants, sulfate surfactants, tau Phosphates (e.g., taurate surfactants), sucrose stearate and other emulsifiers based on sugar esters, glyceryl stearate and other glycerol esters, ethylenedicocamide PEG-15 disodium disulfate, sodium stearoyl glutamate and other fatty amides, steareth-100 and other fatty ethers, cationic surfactants and other cationic compounds, silicones (e.g., silicone polymers, silicone elastomers, and silicone oils) selected from dimethicone, cyclopentasiloxane, cyclohexasiloxane, and combinations thereof, phthalates, parabens, sulfates, polyquaterniums, microplastics, synthetic dyes, gelling agents, and combinations thereof.

[0173] Unless otherwise indicated in the operating examples or otherwise, all numbers expressing amounts of ingredients and / or reaction conditions are understood in all instances to be modified by the term "about" and to mean within 10% of the stated value (e.g., "about 10%" means 9% to 11%, "about 2%" means 1.8% to 2.2%).

[0174] Unless otherwise indicated, all percentages and ratios are calculated by weight.Unless otherwise indicated, all percentages are calculated based on the total composition.Generally, unless otherwise expressly stated herein, "weight" or "amount" used herein for the percentage amount of an ingredient refers to the amount of raw material containing the ingredient, and raw material can be described herein as containing less than 100% and up to 100% active of the ingredient.Therefore, the weight percentage of active material in a composition is expressed as the amount of raw material containing active material used, and may or may not reflect the final percentage of active material, and the final percentage of active material depends on the weight percentage of active material in raw material.

[0175] All ranges and amounts set forth herein are intended to include subranges and amounts using any of the disclosed endpoints. Thus, a range of "1% to 10%, e.g., 2% to 8%, e.g., 3% to 5%" is intended to encompass ranges such as "1% to 8%, 1% to 5%, 2% to 10%, etc. All numbers, amounts, ranges, etc. are intended to be modified by the term "about," whether expressly specified or not. Similarly, a range set forth as "about 1% to 10%" is intended to have the term "about" modify both the 1% and 10% endpoints. Furthermore, when an amount of an ingredient is given, it is understood that it is intended to represent the amount of active material unless otherwise specified.

[0176] Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the present disclosure are approximations, unless otherwise indicated, the numerical values ​​set forth in the specific examples are reported as precisely as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. The following examples serve to illustrate, but are not limiting in nature, embodiments of the present disclosure.

[0177] All publications and patent applications cited herein are incorporated by reference and for any and all purposes to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of a conflict between the present disclosure and a publication or patent application incorporated by reference herein, the present disclosure shall control.

Claims

1. 1. A makeup remover composition comprising a two-phase micellar system comprising an oil phase and an aqueous phase, said system comprising: a. an oil mixture comprising: iii. one or more liquid branched or linear alkanes having a carbon chain length of from C11 to C20, including isohexadecane and isododecane; iv. one or more emollient esters; and b. at least one polymeric thickener for aqueous systems; c. at least one polyglyceryl nonionic surfactant; d. Water, present in an amount of from about 30% to about 70% by weight of the makeup remover composition; The makeup remover composition, wherein the composition is a micellar two-phase composition in which water and oil are present in a water to oil ratio of about 1.5:1 to about 1:1.

5.

2. 10. The makeup remover composition of claim 1, excluding one or more of silicones, alcohols, sulfate-containing compounds, PEG surfactants, xanthan gum, or combinations thereof.

3. 10. The makeup remover composition of claim 1, wherein the one or more emollient esters comprise isopropyl myristate and the at least one polymeric thickener for aqueous systems comprises hydroxyethyl cellulose.

4. 10. The makeup remover composition of claim 1, wherein isohexadecane is present in an amount of from about 15% to about 30% by weight and isododecane is present in an amount of from about 10% to about 20% by weight, calculated by weight of the makeup remover composition.

5. 10. The makeup remover composition of claim 1, wherein isohexadecane is present at about 28% by weight and isododecane is present at about 15% by weight, calculated by weight of the makeup remover composition.

6. 10. The makeup remover composition of claim 1, wherein the one or more emollient esters are present in an amount of from about 1% to about 8% by weight, calculated by weight of the makeup remover composition.

7. 10. The makeup remover composition of claim 1, wherein the one or more emollient esters comprise isopropyl myristate present at about 1% to about 8% by weight, calculated on the weight of the makeup remover composition.

8. 10. The makeup remover composition of claim 1, wherein the total amount of said emollient esters does not exceed about 10% by total weight of said makeup remover composition.

9. 10. The makeup remover composition of claim 1, wherein the at least one polymeric thickener for aqueous systems is present in an amount of from about 0.01% to about 1.0% by weight, calculated on the weight of the makeup remover composition.

10. 10. The makeup remover composition of claim 1, wherein the at least one polymeric thickener for aqueous systems comprises hydroxyethyl cellulose and the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate and polyglyceryl dicaprate.

11. 10. The makeup remover composition of claim 1, wherein the at least one polyglyceryl nonionic surfactant is present in a total amount of from about 0.01% to about 0.2% by weight, calculated by weight of the composition.

12. 2. The makeup remover composition of claim 1, wherein the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate present at about 0.025% by weight and polyglyceryl dicaprate present at about 0.025% by weight, calculated by weight of the composition.

13. 10. The makeup remover composition of claim 1, comprising one or a combination of additives selected from triethyl citrate, sodium hydroxide, panthenol, hydroxyacetophenone, gluconolactone, myrtrimonium bromide, sodium citrate, sodium chloride, dicaprylyl ether, citric acid, or combinations thereof.

14. a. the oil mixture comprises: i. one or more liquid branched or linear alkanes having a carbon chain length of from C11 to C20, comprising isohexadecane present at about 28% by weight and isododecane present at about 15% by weight; ii. one or more emollient esters comprising isopropyl myristate present at about 1% by weight; b. the at least one polymeric thickener for aqueous systems comprises hydroxyethyl cellulose present at about 0.025% by weight; c. the at least one polyglyceryl nonionic surfactant comprises polyglyceryl-6 caprylate present at about 0.025% by weight and polyglyceryl dicaprate present at about 0.025% by weight; d. water is present in about 45% to about 55% by weight; The composition comprises: e. triethyl citrate, f. one or a combination of additives selected from sodium hydroxide, panthenol, hydroxyacetophenone, gluconolactone, myrtrimonium bromide, sodium citrate, sodium chloride, dicaprylyl ether, citric acid, or combinations thereof; All amounts are calculated by weight of the makeup remover composition.

10. The makeup remover composition of claim 1, wherein the composition is a micellar two-phase composition in which water and oil are present in a water to oil ratio of about 1:1, and the makeup remover composition is applied for use and removed by wiping without rinsing with water.

15. 15. The makeup remover composition of claim 14, comprising: a container that contains the makeup remover composition; an outlet connected to the container, such as an outlet that is a spray nozzle; and a spray device that can discharge the makeup remover composition in the container from the outlet, wherein the spray nozzle is a fine mist nozzle that delivers a mist at a pump volume in the range of about 0.01 to about 1.0 ml / pump and generates micron-scale mist particles in the range of about 10 microns to about 900 microns.

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