Aerosol delivery device with microfluidic delivery component

Abstract

Microfluidic vaporizers, aerosol delivery devices that may include such vaporizers, and methods for forming aerosols.SOLUTION: The microfluidic vaporizer 330 can comprise a substrate 345 defining a reservoir 365 configured to hold a liquid, a heater 355 adapted to vaporize the liquid, and a capillary channel 375 configured for movement of the liquid from the reservoir to the heater. The aerosol delivery device can comprise an outer shell and a microfluidic vaporizer. Microfluidic vaporizers and aerosol delivery devices can be used to form aerosols with precise and reproducible compositions.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present disclosure relates to aerosol delivery devices such as smoking articles, and more particularly to aerosol delivery devices (e.g., smoking articles commonly referred to as e-cigarettes) that may utilize electrically generated heat to generate an aerosol. The smoking article may be configured to heat an aerosol precursor, which may be made from tobacco or may incorporate tobacco-derived materials, or may incorporate tobacco, and the precursor can form an inhalable substance for human consumption. [Background technology]

[0002] Many smoking devices have been proposed over the years as an improvement over, or as a replacement for, smoking products that require the burning of tobacco during use. Many of these devices have been intentionally designed to provide the sensations associated with smoking a cigarette, cigar, or pipe, but without delivering significant amounts of incomplete combustion and pyrolysis products resulting from tobacco fuel. To this end, numerous smoking products, flavor generators, and medicinal inhalers have been proposed that utilize electrical energy to vaporize or heat volatile materials, or to attempt to provide the sensation of smoking a cigarette, cigar, or pipe without burning significant amounts of tobacco. See, for example, the various alternative smoking articles, aerosol delivery devices, and heat sources set forth in the Background section of U.S. Patent No. 7,726,320 to Robinson et al., U.S. Patent Application Publication No. 2013 / 0255702 to Griffith Jr. et al., and U.S. Patent Application No. 13 / 647,000 to Sears et al., filed October 8, 2012, which are incorporated by reference in their entireties. See also, for example, the various types of smoking articles, aerosol delivery devices, and electrically-powered heat sources referenced by trade name and commercial source in U.S. Patent Application No. 14 / 170,838 to Bless et al., filed February 3, 2014, which are incorporated by reference in their entireties.

[0003] It is desirable to provide a reservoir for the aerosol precursor composition for use in an aerosol delivery device, and it is also desirable to provide an aerosol delivery device prepared with such a reservoir, where the reservoir is provided to improve the configuration of the aerosol delivery device. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] U.S. Patent No. 7,726,320 [Patent Document 2] US Patent Application Publication No. 2013 / 0255702 Summary of the Invention

[0005] The present disclosure relates to microfluidic devices that can be used in vapor formation. Such microfluidic devices are particularly useful as vaporizers in aerosol delivery devices. Microfluidic vaporizers as described herein can provide precise control over aerosol composition, reduce the amount of liquid that may be needed to form a desired number of aerosol puffs in an aerosol delivery device, and can be useful for reducing the power consumption required to provide the aerosol. The present disclosure further relates specifically to aerosol delivery devices that may incorporate the microfluidic vaporizers described herein, as well as methods of vapor and aerosol formation, methods of making microfluidic vaporizers, and methods of making aerosol delivery devices.

[0006] In some embodiments, the present disclosure provides a microfluidic vaporizer comprising a substrate defining a reservoir configured to hold a liquid, a heater adapted to vaporize the liquid, and a capillary flow path configured for transfer of the liquid from the reservoir to the heater. The microfluidic vaporizer may be further configured according to the following descriptions, any two or more of which may be combined.

[0007] The microfluidic vaporizer may further include a cover overlying the substrate, at least a portion of which may be vapor permeable and liquid impermeable.

[0008] The substrate of the microfluidic vaporizer can be adapted for passive transfer of liquid from a reservoir to a heater via a capillary channel.

[0009] The microfluidic vaporizer may further comprise an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimuli-responsive material, and combinations thereof.

[0010] The liquid in the microfluidic vaporizer can be an aerosol precursor composition or a component thereof. The liquid can include one or more flavors. The one or more flavors can include nicotine, particularly tobacco-derived nicotine. The liquid can include an aerosol former. The aerosol former can be selected from the group consisting of water, glycerin, propylene glycol, and combinations thereof.

[0011] The substrate of the microfluidic vaporizer can include multiple heaters.

[0012] The substrate of the microfluidic vaporizer can include multiple reservoirs.

[0013] The microfluidic vaporizer can include a first reservoir containing an aerosol former and a second reservoir containing one or more flavors. The first and second reservoirs can be in fluid communication with a heater via capillary channels. The first reservoir can be in fluid communication with a first heater via a first capillary channel, and the second reservoir can be in fluid communication with a second heater via a second capillary channel. Alternatively, the first and second reservoirs can be in fluid communication with the same heater. Any number of reservoirs, capillary channels, and heaters can be used in any combination, and the relative numbers of each element in a given embodiment can vary.

[0014] The substrate of the microfluidic vaporizer may further comprise one or more electrical connection pins.

[0015] The reservoir(s) and / or capillary channel(s) defined by the substrate of the microfluidic vaporizer may be etched into the substrate. The reservoir(s) and / or capillary channel(s) may be formed in the substrate by any further suitable method as described further herein.

[0016] A heater of the microfluidic vaporizer can be located below at least a portion of the capillary flow path.

[0017] The microfluidic vaporizer can include a plurality of capillary channels. The plurality of capillary channels can extend radially from the substrate. The microfluidic vaporizer can include a plurality of heaters positioned at the ends of the capillary channels. The heaters can be substantially disk-shaped or may have additional shapes. The capillary channels can be formed within the heaters positioned at the ends of the capillary channels.

[0018] The substrate of the microfluidic vaporizer can be substantially in the form of a chip. Such form factors may comprise materials including, but not limited to, Si and SiO2.

[0019] In some embodiments, the present disclosure provides an aerosol delivery device. The aerosol delivery device can include an outer shell and a microfluidic vaporizer according to any embodiment or combination of embodiments described herein. The aerosol delivery device can be further configured according to the following description, any two or more of which can be combined:

[0020] The aerosol delivery device can include a first shell containing a microfluidic vaporizer and a second shell containing a power source.

[0021] The aerosol delivery device may further comprise a mouthpiece.

[0022] The aerosol delivery device may further comprise a microcontroller.

[0023] The aerosol delivery device can include an input adapted to provide control instructions to the microcontroller. The input can be a touchscreen. The input can be an APP or other computer program installed on a computer or handheld computing device, such as a smartphone or tablet. The input can include one or more push buttons.

[0024] In some embodiments, the aerosol delivery device can include an outer shell and a microfluidic vaporizer, the microfluidic vaporizer including a substrate, one or more liquid flavor reservoirs formed in the substrate, one or more liquid flavors positioned in the liquid flavor reservoirs, one or more liquid aerosol former reservoirs formed in the substrate, a liquid aerosol former in the liquid aerosol former reservoir(s), one or more heaters, a plurality of capillary channels configured for transfer of the liquid flavor(s) and the liquid aerosol former to the heater(s), and one or more electrical connections. The aerosol delivery device can be further configured according to the following description, any two or more of which may be combined.

[0025] The aerosol delivery device can be configured such that the liquid flavor can include nicotine, which can be located in a first liquid flavor reservoir, and at least one additional liquid flavor can be located in a second liquid flavor reservoir.

[0026] The aerosol delivery device can include multiple heaters. The aerosol delivery device can be formed such that a first capillary flow path can be configured for transfer of the liquid aerosol former to a first heater and a second capillary flow path can be configured for transfer of at least one of the liquid flavors to a second heater. In further embodiments, multiple capillary flow paths can be configured for transfer of different components of the aerosol precursor composition (or E-liquid) to the same heater.

[0027] The aerosol delivery device can be configured so that separate liquid flavors can be positioned within separate liquid flavor reservoirs.

[0028] The aerosol delivery device may further comprise a microcontroller.The aerosol delivery device may further comprise an input adapted to provide control instructions to the microcontroller.

[0029] The aerosol delivery device can be configured such that the microfluidic vaporizer further includes a cover overlying the substrate, and the aerosol delivery device can be configured such that at least a portion of the cover can be vapor permeable and liquid impermeable.

[0030] The aerosol delivery device can further comprise an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimuli-responsive material, and combinations thereof. The active transport element can be defined by the substrate or can be included in the outer shell and in active communication with the substrate to effect liquid transport in the substrate.

[0031] The aerosol delivery device can further include a reservoir in fluid communication with the microfluidic vaporizer and capable of containing one or more aerosol precursor components held by or within the reservoir, which can be positioned substantially perpendicular to the microfluidic reservoir.

[0032] In some embodiments, the present disclosure provides a method of forming an aerosol. As an exemplary embodiment, the method of forming an aerosol includes providing an aerosol delivery device according to any embodiment or combination of embodiments described herein, transmitting control signals to a microfluidic vaporizer that transfer a predetermined aliquot of a liquid aerosol former, and optionally, a predetermined aliquot of at least one liquid flavor, to one or more heaters via one or more capillary channels, and transmitting control signals to the microfluidic vaporizer that cause the heater(s) to heat and vaporize the liquid aerosol former and any optional liquid flavor delivered to the heater(s).

[0033] The present invention includes, but is not limited to, the following embodiments.

[0034] Embodiment 1: A microfluidic vaporizer comprising a substrate defining a reservoir configured to hold a liquid, a heater adapted to vaporize the liquid, and a capillary flow path configured for transfer of the liquid from the reservoir to the heater.

[0035] Embodiment 2: A microfluidic vaporizer according to any preceding or following embodiment, further comprising a cover overlying the substrate.

[0036] Embodiment 3: A microfluidic vaporizer according to any preceding or following embodiment, wherein at least a portion of the cover is vapor-permeable and liquid-impermeable.

[0037] Embodiment 4: A microfluidic vaporizer according to any preceding or following embodiment, wherein the substrate is adapted for passive transfer of liquid from the reservoir to the heater via a capillary channel.

[0038] Embodiment 5: A microfluidic vaporizer according to any preceding or following embodiment, further comprising an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimuli-responsive material, and combinations thereof.

[0039] Embodiment 6: A microfluidic vaporizer according to any preceding or following embodiment, wherein the liquid is an aerosol precursor composition, or a component thereof, suitable for use in an aerosol delivery device.

[0040] Embodiment 7: A microfluidic vaporizer according to any preceding or following embodiment, wherein the liquid comprises one or more flavors.

[0041] Embodiment 8: A microfluidic vaporizer according to any preceding or following embodiment, wherein the one or more flavors include nicotine.

[0042] Embodiment 9: A microfluidic vaporizer according to any preceding or following embodiment, wherein the liquid comprises an aerosol former.

[0043] Embodiment 10: The microfluidic vaporizer according to any preceding or following embodiment, wherein the aerosol former is selected from the group consisting of water, glycerin, propylene glycol, and combinations thereof.

[0044] Embodiment 11: A microfluidic vaporizer according to any preceding or following embodiment, wherein the substrate comprises a plurality of heaters.

[0045] Embodiment 12: A microfluidic vaporizer according to any preceding or following embodiment, wherein the substrate comprises a plurality of reservoirs.

[0046] Embodiment 13: A microfluidic vaporizer according to any preceding or following embodiment, comprising a first reservoir containing an aerosol former and a second reservoir containing one or more flavors.

[0047] Embodiment 14: A microfluidic vaporizer according to any preceding or following embodiment, wherein the first and second reservoirs are in fluid communication with the heater via capillary channels.

[0048] Embodiment 15: A microfluidic vaporizer according to any preceding or following embodiment, wherein the first liquid reservoir is in fluid communication with the first heater via a first capillary flow path, and the second liquid reservoir is in fluid communication with the second heater via a second capillary flow path.

[0049] Embodiment 16: A microfluidic vaporizer according to any preceding or following embodiment, wherein the substrate further comprises one or more electrical connections.

[0050] Embodiment 17: A microfluidic vaporizer according to any preceding or following embodiment, wherein the reservoir and capillary channel are etched into the substrate.

[0051] Embodiment 18: A microfluidic vaporizer according to any preceding or following embodiment, wherein the heater underlies at least a portion of the capillary channel.

[0052] Embodiment 19: A microfluidic vaporizer according to any preceding or following embodiment, comprising a plurality of capillary channels, the capillary channels extending radially from the substrate.

[0053] Embodiment 20: A microfluidic vaporizer according to any preceding or following embodiment, comprising a plurality of heaters positioned at the termini of the capillary flow channel.

[0054] Embodiment 21: A microfluidic vaporizer according to any preceding embodiment, wherein the substrate is substantially in the form of a chip.

[0055] Embodiment 22: An aerosol delivery device comprising an outer shell and a microfluidic vaporizer according to any preceding embodiment of the claims.

[0056] Embodiment 23: An aerosol delivery device according to any preceding or following embodiment, wherein the device comprises a first outer shell containing the microfluidic vaporizer, and a second outer shell containing the power source.

[0057] Embodiment 24: An aerosol delivery device according to any preceding or following embodiment, further comprising a mouthpiece.

[0058] Embodiment 25: An aerosol delivery device according to any preceding or following embodiment, further comprising a microcontroller.

[0059] Embodiment 26: An aerosol delivery device according to any preceding or following embodiment, further comprising an input adapted to provide control instructions to the microcontroller.

[0060] Embodiment 27: An aerosol delivery device according to any preceding or following embodiment, further comprising a container in fluid communication with the microfluidic vaporizer, the container containing one or more aerosol precursor components.

[0061] Embodiment 28: An aerosol delivery device comprising: an outer shell; and a microfluidic vaporizer comprising: a substrate; a plurality of liquid flavor reservoirs formed in the substrate; a plurality of liquid flavors positioned within the liquid flavor reservoirs; a liquid aerosol former reservoir formed in the substrate; a liquid aerosol former within the liquid aerosol former reservoir; a heater; a plurality of capillary channels configured for transport of the liquid flavor and the liquid aerosol former to the heater; and one or more electrical connections.

[0062] Embodiment 29: An aerosol delivery device according to any preceding or following embodiment, wherein the plurality of liquid flavors comprises nicotine.

[0063] Embodiment 30: An aerosol delivery device according to any preceding or following embodiment, wherein nicotine is positioned in the first liquid flavor reservoir and at least one additional liquid flavor is positioned in the second liquid flavor reservoir.

[0064] Embodiment 31: An aerosol delivery device according to any preceding or following embodiment, wherein the device comprises multiple heaters.

[0065] Embodiment 32: An aerosol delivery device according to any preceding or following embodiment, wherein the first capillary flow path is configured for transfer of the liquid aerosol former to the first heater, and the second capillary flow path is configured for transfer of at least one of the liquid flavors to the second heater.

[0066] Embodiment 33: An aerosol delivery device according to any preceding or following embodiment, wherein separate liquid flavors are located in separate liquid flavor reservoirs.

[0067] Embodiment 34: An aerosol delivery device according to any preceding or following embodiment, further comprising a microcontroller.

[0068] Embodiment 35: An aerosol delivery device according to any preceding or following embodiment, further comprising an input adapted to provide control instructions to the microcontroller.

[0069] Embodiment 36: An aerosol delivery device according to any preceding or following embodiment, wherein the microfluidic vaporizer further comprises a cover overlying the substrate.

[0070] Embodiment 37: An aerosol delivery device according to any preceding or following embodiment, wherein at least a portion of the cover is vapor-permeable and liquid-impermeable.

[0071] Embodiment 38: An aerosol delivery device according to any preceding or following embodiment, further comprising an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimuli-responsive material, and combinations thereof.

[0072] Embodiment 39: An aerosol delivery device according to any preceding or following embodiment, further comprising a container in fluid communication with the microfluidic vaporizer, the container containing one or more aerosol precursor components.

[0073] Embodiment 40: A method of forming an aerosol, comprising: providing an aerosol delivery device according to any preceding embodiment; transmitting a control signal to a microfluidic vaporizer that causes at least one of a predetermined portion of a liquid aerosol former and a predetermined portion of a liquid flavor to move through a capillary flow path to a heater; and transmitting a control signal to the microfluidic vaporizer that causes the heater to heat and vaporize the liquid aerosol former and liquid flavor delivered to the heater.

[0074] These and other features, aspects, and advantages of the present disclosure will become apparent from a reading of the following detailed description in conjunction with the accompanying drawings, which are briefly described below. The present invention includes any combination of any two, three, four, or more features or elements set forth in this disclosure, as well as any combination of two, three, four, or more of the above-described embodiments, regardless of whether such features or elements are explicitly combined in a particular embodiment description herein. The present disclosure is intended to be read holistically, such that any separable features or elements of the disclosed invention, in any of its various aspects and embodiments, should be considered as intended to be combinable unless the context clearly dictates otherwise.

[0075] Having thus described the present disclosure in general terms above, reference is now made to the accompanying drawings, which are not necessarily to scale, in which: [Brief explanation of the drawings]

[0076] [Figure 1] FIG. 1 is a partial cutaway view of an aerosol delivery device comprising a cartridge and a control body including a microfluidic vaporizer, according to an example embodiment of the present disclosure. [Figure 2] FIG. 1 is a partial cutaway view of an aerosol delivery device including a tipped shell and a microfluidic vaporizer, according to an example embodiment of the present disclosure. [Figure 3] FIG. 1 is a partially exploded view of a microfluidic vaporizer, according to an example embodiment of the present disclosure. [Figure 4] FIG. 10 is a partially exploded view of a further microfluidic vaporizer, according to an example embodiment of the present disclosure. [Figure 5] FIG. 1 is a top view of a microfluidic vaporizer with multiple reservoirs, according to an example embodiment of the present disclosure. [Figure 6] FIG. 1 illustrates a top view of a microfluidic vaporizer with multiple reservoirs positioned radially around a single heater, according to an example embodiment of the present disclosure. [Figure 7] FIG. 1 illustrates a top view of a microfluidic vaporizer with multiple reservoirs and multiple dedicated heaters, according to an example embodiment of the present disclosure. [Figure 8] FIG. 1 is a perspective view of a microfluidic reservoir comprising a reservoir having a plurality of capillary channels extending radially therefrom, with a plurality of heaters positioned at the termini thereof, according to an example embodiment of the present disclosure. [Figure 9] FIG. 1 is a top view of a generally disc-shaped heater having capillary channels and a heater cover (shown detached from the heater for clarity) including micro-perforations covering a heating element formed in a heater bed, the heater according to an example embodiment of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0077] The present disclosure will now be described more fully hereinafter with reference to exemplary embodiments thereof. These exemplary embodiments are described so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. Indeed, the disclosure may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements. As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise.

[0078] As described below, embodiments of the present disclosure relate to aerosol delivery systems. Aerosol delivery systems according to the present disclosure use electrical energy to heat a material (preferably without significant combustion and / or significant chemical alteration of the material) to form an inhalable substance, and components of such systems have article forms that are most preferably small enough to be considered handheld devices. That is, use of preferred aerosol delivery system components does not result in the generation of smoke, i.e., smoke from by-products of tobacco combustion or pyrolysis, but rather, use of these preferred systems results in the generation of vapor resulting from the volatilization or vaporization of certain components incorporated therein. In preferred embodiments, the aerosol delivery system components may be characterized as electronic cigarettes, which most preferably incorporate tobacco and / or tobacco-derived components and thus deliver the tobacco-derived components in aerosol form.

[0079] The aerosol-generating pieces of some preferred aerosol delivery systems can provide many of the sensations (e.g., inhalation and exhalation rituals, types of tastes or flavors, sensory effects, physical sensations, usage rituals, visual cues such as those provided by visible aerosol, and the like) of smoking a cigarette, cigar, or pipe used by lighting and burning tobacco (and thus inhaling tobacco smoke), without significantly burning any of its components. For example, a user of an aerosol-generating piece of the present disclosure can add and use the piece, draw on one end of the piece to inhale the aerosol generated by the piece, puff or smoke at random intervals, etc., much like a smoker would use a conventional type of smoking article.

[0080] The aerosol delivery device of the present disclosure may also be characterized as a vapor-generating article or a drug delivery article. Accordingly, such articles or devices may be adapted to provide one or more substances (e.g., flavors and / or active pharmaceutical ingredients) in an inhalable form or state. For example, the inhalable substance may be substantially in vapor form (i.e., a substance in the gas phase at a temperature below its critical point). Alternatively, the inhalable substance may be in the form of an aerosol (i.e., a suspension of fine solid particles or liquid droplets in a gas). For simplicity, the term "aerosol" as used herein is intended to include vapors, gases, and aerosols in any form or type suitable for human inhalation, whether or not they are visible and whether or not they are in a form that may be perceived as smoke-like.

[0081] The aerosol delivery device of the present disclosure generally includes several components disposed within an exterior body or shell, which may be referred to as a housing. The overall design of the exterior body or shell may vary, as may the type or configuration of the exterior body, which may define the overall size and shape of the aerosol delivery device. The elongated body, which typically resembles the shape of a cigarette or cigar, may be formed from a single, integral housing, or the elongated housing may be formed from two or more separable bodies. For example, the aerosol delivery device may include an elongated shell or body that may be substantially tubular in shape and thus resemble the shape of a traditional cigarette or cigar. In one embodiment, all of the components of the aerosol delivery device are contained within a single housing. Alternatively, the aerosol delivery device may include two or more housings that are joined and separable. For example, an aerosol delivery device may have a control body at one end comprising a housing containing one or more reusable components (e.g., a rechargeable battery and various electronics for controlling the operation of the item) and an outer shell or exterior body at the other end containing a disposable portion removably attached thereto (e.g., a disposable cartridge containing one or more aerosol precursor components, such as flavors or aerosol formers).

[0082] The aerosol delivery devices of the present disclosure may be formed with an outer housing or shell that is not substantially tubular in shape, but may be formed to a substantially larger size. The housing or shell may be configured to include a mouthpiece and / or may be configured to receive a separate shell (e.g., a cartridge) that may include a consumable element, such as a liquid aerosol former, and may also include a vaporizer.

[0083] The aerosol delivery devices of the present disclosure most preferably comprise some combination of a power source (i.e., a power source), at least one control component (e.g., a means for activating, controlling, regulating, or shutting off the heat generation power, such as by controlling the current flow power to other components of the article, e.g., a microcontroller or microprocessor), a heater or heat generating member (e.g., an electrical resistance heating element or other component, which, alone or in combination with one or more additional elements, may commonly be referred to as an "atomizer"), an aerosol precursor composition (e.g., a liquid that can generate an aerosol upon application of sufficient heat, such as the components commonly referred to as "smoke juice," "e-liquid," and "e-juice"), and a mouthpiece or mouth area that allows for drawing on the aerosol delivery device during aerosol inhalation (e.g., a defined air flow path through the article through which the generated aerosol may be drawn upon inhalation).

[0084] More specific forms, configurations, and arrangements of components within the aerosol delivery systems of the present disclosure will become apparent in light of the further disclosure provided below. Also, the selection and arrangement of various aerosol delivery system components can be understood upon review of commercially available electronic aerosol delivery devices, such as those exemplary products mentioned in the Background section of this disclosure.

[0085] An example of an embodiment of an aerosol delivery device 100 according to the present disclosure is provided in FIG. 1. As seen in the cutaway view shown therein, the aerosol delivery device 100 can include a control body 102 and a cartridge 104, which can be permanently or removably aligned in functional relationship. The engagement between the control body 102 and the cartridge 104 can be a press fit (as shown), a threaded fit, an interference fit, a magnet, or similar methods. Specifically, connecting components as described further herein can be used. For example, the control body can include a coupling adapted to engage a connector on the cartridge.

[0086] In certain embodiments, one or both of the control body 102 and the cartridge 104 may be disposable or reusable. For example, the control body may have a replaceable or rechargeable battery and thus may be combined with any type of recharging technology, including connection to a typical electrical outlet, a car charger (i.e., a cigarette lighter receptacle), or even a computer, such as through a Universal Serial Bus (USB) cable. For example, an adapter including a USB connector on one end and a control body connector on the other end is disclosed in U.S. patent application Ser. No. 13 / 840,264, filed March 15, 2013, by Novak et al., which is incorporated herein by reference in its entirety. Furthermore, in some embodiments, the cartridge may include a single-use cartridge, such as that disclosed in U.S. patent application Ser. No. 13 / 603,612, filed September 5, 2012, by Chang et al., which is incorporated herein by reference in its entirety.

[0087] 1 , the control body 102 may be formed with a control body shell 101 that may include a control component 106 (e.g., a microcontroller), a flow sensor 108, a battery 110, and LEDs 112, which may be variably arranged. Additional indicators (e.g., haptic feedback components, audio feedback components, or similar components) may be included in addition to or in place of the LEDs. Additional exemplary types of components providing visual cues or indicators, such as light-emitting diode (LED) components, and their construction and use, are described in U.S. Patent No. 5,154,192 to Sprinkel et al., U.S. Patent No. 8,499,766 to Newton, U.S. Patent No. 8,539,959 to Scatterday, and U.S. Patent Application No. 14 / 173,266 to Sears et al., filed February 5, 2014, which are incorporated herein by reference.

[0088] The cartridge 104 can include, among other things, a microfluidic vaporizer 130. Such a vaporizer can take on a wide variety of configurations as otherwise described herein.

[0089] The cartridge shell 103 may have an opening 128 (e.g., at the mouth end) to allow the formed aerosol to exit the cartridge 104. Such components are representative of components that may be found in a cartridge and are not intended to limit the scope of cartridge components included in this disclosure.

[0090] Cartridge 104 may also include one or more electronic components 150, which may include integrated circuits, memory components, sensors, or the like. Electronic components 150 may be adapted to communicate with control component 106 and / or with external devices by wired or wireless means. Electronic components 150 may be located anywhere within cartridge 104 or its base 140.

[0091] Although the control component 106 and the flow sensor 108 are shown separately, it is understood that the control component and the flow sensor can be combined as an electronic circuit board with the mass airflow sensor mounted directly thereto. Furthermore, the electronic circuit board can be positioned horizontally relative to the view of Figure 1, since the electronic circuit board can be longitudinally parallel to the central axis of the control body. In some embodiments, the mass airflow sensor can comprise its own circuit board or other base element to which the mass airflow sensor can be mounted.

[0092] The control body 102 and cartridge 104 may include components adapted to facilitate fluid engagement therebetween. As shown in FIG. 1 , the control body 102 may include a coupling 124 having a cavity 125 therein. The cartridge 104 may include a base 140 adapted to engage the coupling 124 and may include a protrusion 141 adapted to fit within the cavity 125. Such engagement may facilitate a stable connection between the control body 102 and the cartridge 104, as well as establish an electrical connection between the battery 110 and control component 106 within the control body and the microfluidic vaporizer 130 within the cartridge. Additionally, the control body shell 101 may include an air intake 118, which may be a notch in the shell where it connects to the coupling 124, allowing the passage of ambient air around the coupling and into the shell where it penetrates the cavity 125 of the coupling, and into the cartridge 141 via the protrusion 141.

[0093] Useful couplers and bases according to the present disclosure are described in U.S. Patent Application No. 13 / 840,264, filed March 15, 2013, by Novak et al., the entire disclosure of which is incorporated herein by reference. For example, a coupler as seen in FIG. 1 may define an outer periphery 126 configured to mate with an inner periphery 142 of a base 140. In one embodiment, the inner periphery of the base may define a radius approximately equal to or slightly greater than the radius of the outer periphery of the coupler. Additionally, coupler 124 may define one or more protrusions 129 on outer periphery 126 configured to engage one or more recesses 178 defined in the inner periphery of the base. However, various other embodiments of structures, shapes, and components may be employed to couple a base. In some embodiments, the connection between the base 140 of the cartridge 104 and the coupling 124 of the control body 102 may be substantially permanent, while in other embodiments, the connection therebetween may be releasable, for example, so that the control body may be reused with one or more additional cartridges, which may be disposable and / or refillable.

[0094] The aerosol delivery device 100 may, in some embodiments, be substantially rod-like, or substantially tubular, or substantially cylindrical in shape. In other embodiments, additional shapes and dimensions are included, such as rectangular or triangular cross-sections, or the like.

[0095] During use, when a user inhales on article 100, airflow is detected by sensor 108, activating microfluidic vaporizer 130 and vaporizing the aerosol precursor composition located within the microfluidic vaporizer. Drawing on the mouth end of article 100 forces ambient air into air intake 118 and through cavity 125 in coupling 124 and a central opening in protrusion 141 of base 140. In cartridge 104, the inhaled air combines with the formed vapor to form an aerosol. The aerosol leaves the microfluidic vaporizer and is quickly moved out of mouth opening 128 at the mouth end of article 100.

[0096] A further exemplary embodiment of an aerosol delivery device 200 according to the present disclosure is illustrated in partial cross section in FIG. 2 . The aerosol delivery device 200 includes a shell 201 that is generally rectangular in shape but may assume any additional shape as desired and is appropriately sized to accommodate additional elements of the device. Also located within the shell 201 are a battery 210, a microcontroller 206, and a sensor 208. The aerosol delivery device 200 in such an embodiment may include a microfluidic vaporizer 230 that may be positioned within a vapor chamber 235. Specifically, the microfluidic vaporizer 230 may include one or more electrical connection pins (not shown in FIG. 2 ) that allow electrical attachment of the microfluidic vaporizer via a connection port 237. Thus, the microfluidic vaporizer 230 may be removable and replaceable. The aerosol delivery device 200 may include a mouthpiece 220 for passage of the formed aerosol to a user of the device. The mouthpiece 220 may be fluidly connected to the vapor chamber (or directly to the microfluidic vaporizer) via the aerosol passage 222, and the mouthpiece may be retractable into the aerosol passage or into a further cavity or recess within the aerosol delivery device 200.

[0097] As described further herein, a microfluidic vaporizer can include a substrate defining at least one reservoir therein for receiving one or more aerosol precursor components (or the complete aerosol precursor composition). In some embodiments, the reservoir may be provided in fluid connection with the microfluidic vaporizer or may be complementary to any reservoir defined by the microfluidic vaporizer substrate. In other embodiments, the microfluidic vaporizer substrate may lack a reservoir, and a separate reservoir may be provided in fluid connection with the microfluidic vaporizer. For example, as shown in FIG. 2 , a reservoir 266 is fluidly connected to the microfluidic vaporizer 230 via a liquid transport element 268. The reservoir 266 may be in any form suitable for holding liquid components therein or thereby. For example, the reservoir may be a bottle or other walled element having a wall that is substantially impermeable to and non-reactive with any aerosol precursor components held therein. As a further example, the container 266 may be a fibrous material into which the liquid aerosol precursor components are absorbed, absorbed, or stored within or by it. The liquid transport element 268 may be of any form suitable for transporting liquid from the container 266 to the microfluidic vaporizer 230. For example, the liquid transport element 268 may be fibrous, particulate, or a wick suitable for wicking liquid along its length by capillary action. In a further embodiment, the liquid transport element 268 may be a capillary channel and thus may be substantially in the form of a flow tube appropriately sized to promote capillary action during movement of liquid therethrough. In yet a further embodiment, the liquid transport element 268 may be sized so that capillary action is reduced or substantially absent, and liquid transport may be facilitated by one or more pumps or the like. Additionally, one or more valves may be present within the liquid transport element 268. The container 266 may be in any spatial configuration with the microfluidic vaporizer 230. In some embodiments, the vessel 266 can be substantially perpendicular to the microfluidic vaporizer 230 .Additionally, multiple reservoirs may be used. Liquid transport element 268 may transport liquid directly to a heater or heated zone on microfluidic vaporizer 230 and / or to a reservoir defined by the substrate of the microfluidic vaporizer (depending on whether reservoir 266 is used in place of or supplements a reservoir defined by the microfluidic vaporizer).

[0098] The aerosol delivery device may include an input element. To this end, a touchscreen 209, represented by a dashed line, is shown in FIG. 2 as optionally present and accessible from the exterior of the aerosol delivery device 200. A touchscreen (or other input) may be included to allow a user to control device functions and / or for outputting information to the user. While FIG. 2 shows a touchscreen 209, the aerosol delivery device is not limited to one embodiment. Rather, any component or combination of components may be utilized as an input for controlling device functions. For example, one or more pushbuttons may be used. As a further example, a component adapted for gesture recognition based on specific movements of the aerosol delivery device may be used as an input. See U.S. Patent Application No. 14 / 565,137, filed December 9, 2014, by Henry et al., which is incorporated herein by reference.

[0099] In some embodiments, the input may include a computer or computing device such as a smartphone or tablet. Specifically, the aerosol delivery device may be wired to a computer or other device, such as via a USB cord or similar protocol. The aerosol delivery device may also communicate with a computer or other device that serves as an input via wireless communication. See, for example, the system and method for controlling a device via a read request, as described in U.S. Patent Application No. 14 / 327,776, filed July 10, 2014, by Ampolini et al., the disclosure of which is incorporated herein by reference. In such embodiments, an APP or other computer program may be used in connection with the computer or other computing device to input control instructions to the aerosol delivery device, including, for example, the ability to form an aerosol of a specific composition by selecting the nicotine content and / or additional flavor content to be included.

[0100] The various components of the aerosol delivery device according to the present disclosure can be selected from those described in the art and commercially available. An example of a battery that can be used according to the present disclosure is described in U.S. Patent Application Publication No. 2010 / 0028766 to Peckerar et al., the disclosure of which is incorporated herein by reference in its entirety.

[0101] The aerosol delivery device can incorporate a sensor or detector for controlling the supply of power to the heating element when aerosol generation is desired (e.g., during in-use inhalation). Thus, for example, a manner or method is provided for turning off power to the heating element when the aerosol delivery device is in use and not being inhaled, and for turning on power to activate or cause heat generation by the heating element during inhalation. Additional exemplary types of sensing or detection mechanisms, their structure and configuration, their components, and their general methods of operation are described in U.S. Patent No. 5,261,424 to Sprinkel, Jr., U.S. Patent No. 5,372,148 to McCafferty et al., and PCT Publication No. WO 2010 / 003480 to Flick, which are incorporated herein by reference.

[0102] Most preferably, the aerosol delivery device incorporates a control mechanism for controlling the amount of power to the heat generating element during inhalation. Exemplary types of electronic components, their construction and configuration, their features, and their general methods of operation are described in U.S. Patent No. 4,735,217 to Gerth et al., U.S. Patent No. 4,947,874 to Brooks et al., U.S. Patent No. 5,372,148 to McCafferty et al., U.S. Patent No. 6,040,560 to Fleischhauer et al., U.S. Patent No. 7,040,560 to Nguyen ... 314, U.S. Patent No. 8,205,622 to Pan, U.S. Patent Application Publication No. 2009 / 0230117 to Fernando et al., U.S. Patent Application Publication No. 2014 / 0060554 to Collett et al., U.S. Patent Application No. 13 / 837,542 to Ampolini et al., filed March 15, 2013, and U.S. Patent Application No. 14 / 209,191 to Henry et al., filed March 13, 2014.

[0103] In various embodiments, the present disclosure is particularly beneficial in that the use of a microfluidic vaporizer in an aerosol delivery device can enable precise delivery (and dispensing) of a desired amount of liquid aerosol precursor to a heated zone. Many conventional aerosol delivery devices (e.g., electronic cigarettes) utilize a combination of a fibrous wick and a resistive heating coil to form vapor by naturally wicking liquid from a reservoir (typically a fibrous mat) through the fibrous wick to the resistive heating coil. As liquid is vaporized by the resistive heating coil, more and more liquid naturally wicks from the reservoir to the heater. Such devices suffer from imprecise control of vapor formation, i.e., an inability to deliver a puff of aerosol precursor to the heated zone at the desired time. Such devices equally suffer from an inability to deliver the precise amount of energy needed to quickly vaporize the aerosol precursor liquid in order to provide aerosol on demand and avoid unnecessary energy consumption in the battery.

[0104] Microfluidic vaporizers according to embodiments of the present disclosure can provide precision in vapor information lacking in known devices. As used herein, the term "microfluidic" is intended to refer to the transfer of small volumes of liquid, such as submilliliter, submicroliter, subnanoliter, or subpicoliter volumes. The ability to transfer small, precise volumes of liquid from a reservoir to a heater can result in enhanced vapor formation and reduced unnecessary power consumption.

[0105] In some embodiments, a microfluidic vaporizer can include a substrate that defines certain components of the vaporizer. Specifically, the substrate can define a reservoir configured to hold a liquid (e.g., an aerosol precursor composition or a component thereof), a heater adapted to vaporize the liquid, and a capillary channel configured for transfer of the liquid from the reservoir to the heater. The substrate can be formed of any material that is sufficiently inert to the liquid and the heating levels required for vaporization. Specifically, the substrate is preferably chemically non-reactive with the components of the aerosol precursor composition (including aerosol formers, flavors, and the like). The substrate is also preferably thermally and mechanically stable under use conditions. For example, the substrate can be formed of a material that is temperature stable at temperatures of about 100°C or higher, about 150°C or higher, about 200°C or higher, about 300°C or higher, about 400°C or higher, or about 500°C or higher. In other embodiments, the support layer can be temperature stable in a temperature range of about 100°C to about 750°C, about 125°C to about 650°C, or about 150°C to about 500°C. In some embodiments, the support layer can be formed of a ceramic material, specifically a silicon-based material. One specific example of a support layer material is a silicon nitride material. However, other materials, such as glass or quartz, can be used. Certain thermoplastic materials, such as cyclic olefin copolymer (COC), can also be used.

[0106] The substrate can assume a wide variety of shapes. In some embodiments, the substrate can be substantially chip-shaped, although such a shape is not required. The term "chip shaped" is intended to refer to a shape that is generally flat and has a length and width both greater than its thickness. A chip-shaped substrate may be substantially square or rectangular, although other shapes (e.g., circular, oval, triangular, or other multi-sided shapes) may also be considered chip-shaped if they are generally flat. In light of these exemplary shapes, the microfluidic vaporizer may, in some embodiments, be characterized as a "lab-on-a-chip." This allows the substrate to contain multiple elements required for liquid vaporization. In some embodiments, the substrate can be relatively thin, e.g., about 1 mm to about 20 mm, about 1.5 mm to 15 mm, or about 2 mm to 10 mm. In some embodiments, the substrate can be approximately 0.5 cm thick. 2 ~about 50cm 2 , about 1cm 2 ~approx. 45cm 2 , about 2 cm 2 ~about 40cm 2 , or about 3 cm 2 ~30cm 2 The surface area of ​​the substrate may be 1000 nm or less.

[0107] One embodiment of a microfluidic vaporizer 330 is shown in FIG. 3. In the illustrated embodiment, the microfluidic vaporizer 330 includes a substrate 345 that is substantially chip-shaped. A heater 355 is defined by the substrate 345 and can be positioned on the substrate in a variety of ways. For example, the heater 355 may be located on the top surface 345a of the substrate 345 or on the bottom surface 345b of the substrate. If located on the bottom surface 345b of the substrate 345, the substrate is preferably sufficiently thermally conductive to achieve vaporization of the liquid. In some embodiments, the heater 355 may be embedded in the substrate 345, such as being positioned within a depression or other recess in the substrate. In the illustrated embodiment, the heater 355 is positioned within a depression formed in the substrate 345 and is covered by a thermally conductive layer 347 (shown in FIG. 3 as being partially transparent to reveal the heater 355 positioned below the thermally conductive layer).

[0108] In some embodiments, the heater may be characterized as a microheater. Specifically, the microheater may be characterized as a micro-electro-mechanical systems (MEMS)-based heater. MEMS-based heaters have previously been used in ultra-small microsensors, such as wind sensors, humidity sensors, and gas sensors. Such MEMS-based microheaters can radiate heat by applying a current to a resistor and can offer advantages such as low power input requirements and very short response times. As currently described, MEMS-based microheaters are highly advantageous in microfluidic vaporizers because they can provide low-voltage and / or low-power device functionality while also providing rapid heating to a thermal range high enough to vaporize liquid aerosol precursor compositions.

[0109] Microheaters useful herein may be described as thin film heaters or hot film heaters. This may specifically describe the physical properties of the microheater, which may include a conductive material, i.e., a conductive layer, that may be provided in the form of a film. In some embodiments, the conductive material may be patterned. In other words, the conductive material may be present in the microheater in a specific pattern, thus corresponding to the physical properties of the finished microheater and not limited by the method of fabricating the microheater. The thickness of the conductive layer may vary, for example, about 1000 μm or less, about 500 μm or less, about 200 μm or less, about 100 μm or less, about 50 μm or less, about 10 μm or less, or about 5 μm or less. In other embodiments, the conductive layer may have a thickness of about 0.1 μm to about 500 μm, about 0.5 μm to about 200 μm, about 1 μm to about 100 μm, or about 2 μm to about 50 μm.

[0110] The conductive material used in the microheater can include essentially any material that is conductive and suitable for thin film formation in the size ranges described above. For example, the conductive material can be selected from the group consisting of elemental metals, metal alloys, silicon (including single crystal silicon and polysilicon), ceramics, carbon, carbides, nitrides, and combinations thereof. In more specific embodiments, the conductive material can be formed from platinum, gold, silver, copper, aluminum, tungsten, zinc, palladium, nickel, titanium, nichrome, silicon carbide, polysilicon, single crystal silicon, titanium nitride, and the like. In certain embodiments, elemental metals such as platinum can be particularly beneficial because they exhibit excellent oxidation resistance and long-term stability. Thin film microheaters according to the present disclosure can exhibit high levels of ruggedness and stability, which can be preferred over more brittle and less stable hot wires.

[0111] The use of microheaters in microfluidic vaporizers can be particularly beneficial in that, in some embodiments, the material used to form at least the microheater portion of the microfluidic vaporizer can be a semiconductor (or have properties consistent therewith). Thus, the semiconductor used to form the microheater can be doped to preferentially modulate or tune its electrical properties.

[0112] In addition to the conductive layer, a microheater according to the present disclosure can include a support layer. Specifically, the conductive layer may be patterned on such a support layer. The support layer is preferably formed of a material that is temperature stable under the operating temperature of the heater. For example, the support layer can be temperature stable at temperatures of about 150°C or higher, about 200°C or higher, about 300°C or higher, about 400°C or higher, or about 500°C or higher. In other embodiments, the support layer can be temperature stable in a temperature range of about 125°C to about 750°C, about 150°C to about 650°C, or about 175°C to about 500°C. In some embodiments, the support layer can be formed of a ceramic material, specifically a silicon-based material. One specific example of a support layer material is a silicon nitride material. However, other materials, such as glass or quartz, can be used. Certain thermoplastic materials, such as cyclic olefin copolymer (COC), can also be used. The support layer can be formed of an insulating material or can include an insulating layer. An exemplary microheater that may be useful according to the present disclosure is described in US Pat. No. 8,881,737 to Collett et al., which is incorporated herein by reference.

[0113] The thermally conductive layer 347 is formed of a material that is thermally emissive and / or thermally conductive, such that the thermally conductive layer is temperature stable at the operating temperatures associated with the heater. For example, the thermally conductive layer 347 can be temperature stable at temperatures of about 100°C or higher, about 150°C or higher, about 200°C or higher, about 400°C or higher, or about 500°C or higher. In other embodiments, the thermally conductive layer can be temperature stable in a temperature range of about 100°C to about 750°C, about 150°C to 650°C, or about 175°C to about 500°C. In some embodiments, the thermally conductive layer can be in direct contact with the aerosol precursor composition or its components. Therefore, it is preferred that the thermally conductive layer be substantially chemically non-reactive with various compounds that may be included in the aerosol precursor material. Substantially chemically non-reactive means that any chemical reaction between the thermally conductive layer and the components of the aerosol precursor material is sufficiently limited so as not to disrupt the thermally conductive layer, allowing the aerosol precursor composition to be in direct contact with the conductive layer of the heater. Alternatively, this phrase can mean that any chemical reaction between the thermally conductive layer and the components of the aerosol precursor material is sufficiently limited so that compounds in the thermally conductive layer are not released to combine with the aerosol formed for inhalation by the consumer. In some embodiments, the thermally conductive layer can be formed of a ceramic material, specifically a silicon-based material. One specific example of a thermally conductive layer material is a silicon dioxide material. However, other materials, such as glass or quartz, can be used.

[0114] The substrate 345 of the microfluidic vaporizer 330 shown in Figure 3 can further include a reservoir 365 configured to hold the aerosol precursor composition 367 (or an element thereof). The reservoir can specifically be a depression or other recess formed in the substrate 345. In other embodiments, the microfluidic vaporizer 330 can have a multi-layer structure (see Figure 4).

[0115] Although only one reservoir is shown in Figure 3, it is understood that multiple reservoirs may be included. Additionally, the liquid for aerosolization may be stored separately in multiple reservoirs.

[0116] The aerosol precursor composition, or vapor precursor composition, can vary. Most preferably, the aerosol precursor is composed of a compound or mixture of various components or constituents. The selection of specific aerosol precursor components and the relative amounts of those components used may be modified to control the overall chemical composition of the mainstream aerosol generated by the aerosol-generating piece. Aerosol precursors that can be characterized as being substantially liquid in nature are of particular interest. For example, a typical substantially liquid aerosol precursor may have the form of a solution, a mixture of miscible components, or a liquid incorporating suspended or dispersed components. Typical aerosol precursors can be vaporized under heat under conditions experienced during use of the aerosol-generating piece, characteristic of the present disclosure, thereby producing a respirable vapor and aerosol.

[0117] In aerosol delivery systems characterized as electronic cigarettes, the aerosol precursor most preferably incorporates tobacco or tobacco-derived components. In one aspect, tobacco may be provided as tobacco parts or pieces, such as finely ground, powdered, or powdered tobacco lamina. In another aspect, tobacco may be provided in the form of an extract, such as a spray-dried extract that incorporates many of the water-soluble components of tobacco. Alternatively, the tobacco extract may have the form of a relatively high nicotine content extract, which also incorporates small amounts of other extracted components derived from tobacco. In another aspect, tobacco-derived components, such as some tobacco-derived flavoring agents, may be provided in a relatively pure form. In one aspect, a component derived from tobacco, and which may be employed in a purified or essentially pure form, is nicotine (e.g., pharmaceutical-grade nicotine).

[0118] Aerosol precursors may incorporate so-called "aerosol formers." Such materials have the ability to produce a visible aerosol when vaporized under heat under conditions experienced during normal use of the aerosol-generating pieces characteristic of the present disclosure. Such aerosol-forming materials include various polyols or polyhydric alcohols (e.g., glycerin, propylene glycol, and mixtures thereof). Many embodiments of the present disclosure incorporate aerosol precursor components that can be characterized as water, moisture, or aqueous liquids. Under normal conditions of use of certain aerosol-generating pieces, water incorporated within those pieces can vaporize and produce a portion of the aerosol that is generated. Therefore, for purposes of the present disclosure, water present in an aerosol precursor may be considered an aerosol-forming material.

[0119] A wide variety of optional flavoring agents or materials can be employed to alter the sensory characteristics or properties of the mainstream aerosol produced and inhaled by the aerosol delivery system of the present disclosure. For example, such optional flavoring agents may be used in the aerosol precursor to alter the flavor, aroma, and sensory characteristics of the aerosol. Some flavoring agents may be provided from sources other than tobacco. Exemplary flavoring agents may be natural or artificial in nature and may be employed as concentrates or flavor packages.

[0120] Exemplary flavoring agents include vanillin, ethyl vanillin, cream, tea, coffee, fruit (e.g., apple, cherry, strawberry, peach, and citrus flavors including lime and lemon), maple, menthol, mint, peppermint, spearmint, wintergreen, nutmeg, clove, lavender, cardamom, ginger, honey, anise, sage, cinnamon, sandalwood, jasmine, cascara, cocoa, licorice, and flavorings and flavor packages of the type and characteristics traditionally used in flavoring cigarettes, cigars, and pipe tobacco. Syrups such as high-fructose corn syrups may also be employed. Some flavoring agents may be incorporated into the aerosol-forming materials prior to formulation of the final aerosol precursor mixture (e.g., some water-soluble flavoring agents may be incorporated into water, menthol may be incorporated into propylene glycol, and some complex flavor packages may be incorporated into propylene glycol). Some tobacco extracts containing nicotine can be characterized as flavors that can be combined with one or more aerosol formers.

[0121] The aerosol precursor may also include components exhibiting acidic or basic properties (e.g., organic acids, ammonium salts, or organic amines). For example, certain organic acids (e.g., levulinic acid, succinic acid, lactic acid, and pyruvic acid) may be included in aerosol precursor formulations incorporating nicotine, preferably in amounts up to an equimolar amount (based on total organic acid content) with nicotine. For example, the aerosol precursor may include about 0.1 to about 0.5 moles of levulinic acid per mole of nicotine, about 0.1 to about 0.5 moles of succinic acid per mole of nicotine, about 0.1 to about 0.5 moles of lactic acid per mole of nicotine, about 0.1 to about 0.5 moles of pyruvic acid per mole of nicotine, or various permutations or combinations thereof, up to a concentration such that the total amount of organic acids present is equimolar to the total amount of nicotine present in the aerosol precursor.

[0122] As one non-limiting example, a typical aerosol precursor may have the form of a mixture of, by weight, about 70% to about 90% glycerin, often about 75% to about 85% glycerin, about 5% to about 20% water, often about 10% to about 15% water, about 1% to about 10% propylene glycol, often about 4% to about 8% propylene glycol, about 0.1% to about 6% nicotine, often about 1.5% to about 5% nicotine, and optional flavorings in an amount up to about 6%, often about 0.1% to about 5% flavorings. For example, a typical aerosol precursor may have the form of a formulation incorporating, by weight, greater than about 76% glycerin, about 14% water, about 7% propylene glycol, about 1% to about 2% nicotine, and less than about 1% optional flavorings. For example, a typical aerosol precursor may have the form of a formulation incorporating, by weight, greater than about 75% glycerin, about 14% water, about 7% propylene glycol, about 2.5% nicotine, and less than about 1% optional flavorings. For example, a typical aerosol precursor may have the form of a formulation incorporating, by weight, greater than about 75% glycerin, about 5% water, about 8% propylene glycol, about 6% nicotine, and less than about 6% optional flavorings.

[0123] As another non-limiting example, a typical aerosol precursor may have the form of a mixture, by weight, of about 40% to about 70% glycerin, often about 50% to about 65% glycerin, about 5% to about 20% water, often about 10% to about 15% water, about 20% to about 50% propylene glycol, often about 25% to about 45% propylene glycol, about 0.1% to about 6% nicotine, often about 1.5% to about 5% nicotine, about 0.5% to about 3%, often about 1.5% to about 2%, menthol, and optional additional flavoring agent in an amount up to about 6%, often about 0.1% to about 5% flavoring agent. For example, a typical aerosol precursor may have the form of a formulation incorporating, by weight, about 50% glycerin, about 11% water, about 28% propylene glycol, about 5% nicotine, about 2% menthol, and about 4% other flavoring agents.

[0124] Exemplary types of aerosol precursor components and formulations are also described and characterized in U.S. Pat. No. 7,217,320 to Robinson et al., U.S. Patent Application Publication No. 2013 / 0008457 to Zheng et al., U.S. Patent Application Publication No. 2013 / 0213417 to Chong et al., and U.S. Patent Application Publication No. 2014 / 0060554 to Collett et al., the disclosures of which are incorporated herein by reference. Other aerosol precursors that may be employed include the aerosol precursors incorporated into VUSE® products by RJ Reynolds Vapor, Inc., BLU™ products by Lorillard Technologies, MISTIC MENTHOL products by Mistic Ecigs, and VYPE products by CN Creative Ltd. So-called "smoke juice" for e-cigarettes, available from Johnson Creek Enterprises LLC, is also desirable.

[0125] The amount of aerosol precursor incorporated into the aerosol delivery system is an amount sufficient to provide an aerosol-generating piece with an acceptable feel and desirable operating characteristics. For example, it is highly preferred that a sufficient amount of aerosol-forming material (e.g., glycerin and / or propylene glycol) be employed to provide the generation of a visible mainstream aerosol that resembles the appearance of cigarette smoke in many respects. The amount of aerosol precursor in the aerosol-generating system can depend on factors such as the number of puffs desired per aerosol-generating piece. Typically, the amount of aerosol precursor incorporated into the aerosol delivery system, and specifically the aerosol-generating piece, is less than about 2 g, typically less than about 1.5 g, often less than about 1 g, and often less than about 0.5 g.

[0126] When multiple reservoirs are utilized, various combinations of the individual components of the aerosol precursor composition may be stored in the reservoirs. In some embodiments, substantially the entire aerosol precursor composition may be stored in two or more separate reservoirs. In some embodiments, the aerosol former (e.g., glycerin, propylene glycol, and water) may be stored in one or more reservoirs, and one or more flavors may be stored in one or more additional reservoirs. In some embodiments, the aerosol former may be stored in one or more reservoirs, nicotine as the primary flavor may be stored in one or more additional reservoirs, and optional additional flavors may be stored in one or more optional additional reservoirs (although the optional flavors may be combined with the nicotine and / or the aerosol former). Other combinations of materials stored in separate reservoirs are also included, and such ability to store materials separately can provide precise control of the aerosol composition provided. Specifically, aerosol compositions may be tailored on an aerosol delivery system that includes a microfluidic vaporizer so that liquid is drawn from only the specific reservoirs needed to provide the desired aerosol composition in a particular puff. This capability is further described below with respect to FIG. 4.

[0127] Referring back to FIG. 3 , the substrate further comprises multiple capillary channels 375. It will be appreciated that one or more capillary channels 375 may be utilized to effect delivery of the precise amount of aerosol precursor composition 367 from the reservoir 365 to the heater 355 necessary to provide the desired amount of aerosol former. The orientation of the capillary channels 375 may vary. For example, the capillary channels may be curved or angled rather than straight. Multiple capillary channels 375 may converge or combine through a branching effect. For example, a single capillary channel exiting the reservoir may branch into multiple capillary channels before or after contacting the heater. Other capillary channel configurations that may be found based on the currently described exemplary embodiment are also encompassed by the present disclosure.

[0128] In FIG. 3 , the capillary channel 375 is shown as terminating at the thermally conductive layer 347. In some embodiments, the thermally conductive layer 347 may be adapted to dissipate the delivered aerosol precursor composition 367 over the underlying heater 355. Thus, the thermally conductive layer 347 may be at least partially recessed into the substrate 345 (e.g., in a depression or recess in which the heater 355 is located) such that the surface of the thermally conductive layer is lower than the top surface 345a of the substrate. In other embodiments, the capillary channel 375 may extend at least partially across the thermally conductive layer 347. In further embodiments, the thermally conductive layer 347 may be absent, and the top surface 345a of the substrate 345 may extend across or straddle the heater 355. Thus, the capillary channel 375 formed in the substrate 345 may extend at least partially across the location of the heater 355 within or below the substrate. Thus, in some embodiments, the heater can underlie at least a portion of one or more capillary channels.

[0129] The microfluidic vaporizer 330 may operate based on one or both of passive and active microfluidic transfer. Passive microfluidic transfer may rely on surface or capillary forces to transport liquid through or along a capillary channel. Therefore, various factors (e.g., liquid viscosity, liquid density, liquid surface tension, contact angle in the capillary channel, surface structure in the capillary channel, and channel geometry) may be adjusted to achieve a desired level of passive transfer. In passive microfluidic transfer, liquid may freely move from the reservoir to the heater as it is vaporized and moves away from the heater.

[0130] Active microfluidic transfer may rely at least in part on capillary forces for liquid transfer, but also applies external factors to transfer only specific amounts of specific liquids directly from specific reservoirs to a heater for vaporization. Active transport elements that may be included in microfluidic vaporizers as described herein may be selected from the group consisting of, for example, valves, pumps, heaters, electric field formers, stimuli-responsive polymers, and combinations thereof. For example, valves may be opened and closed on command to allow liquid to flow by capillary action (or by applying other forces) only when desired; micropumps may be used to increase liquid flow rates beyond those possible by capillary forces alone; heaters may be used to heat areas around capillary channels to create thermal gradients that affect liquid flow rates; electric field formers may be used to establish fields that affect liquid transport; and stimuli-responsive materials (e.g., smart polymers) may be used in channel formation and / or substrate formation so that liquid transport can be affected by changes in the properties of the capillary channels, such as changes in their shape, conductivity, and the like, in response to applied heat, electric fields, or the like.

[0131] 3, to illustrate active transport elements that may be incorporated into the microfluidic vaporizer 330, a valve 377 is shown in each of the capillary channels 375. The valves 377 may be opened to allow transfer of the aerosol precursor composition 367 from the reservoir 365 to the heater 355 for vaporization.

[0132] The capillary channels can be formed by a variety of methods. For example, the channels can be etched or imprinted into the substrate. In other embodiments, deposition or bonding can be used to add the channels to the substrate, or soft lithography techniques such as polydimethylsiloxane (PDMS) lithography can be used. In still further embodiments, the channels can be formed or added using methods such as stereolithography, photolithography, electroplating, injection molding, and embossing.

[0133] Microfluidic vaporizer 330 includes a cover 385 to cover substrate 345, thereby retaining aerosol precursor composition 367 within reservoir 365 and capillary channel 375. Cover 385 includes a plurality of microperforations 387 that are preferably sized to prevent the escape of liquid but allow the passage therethrough of formed vapor. Cover 385 may be substantially in the form of a mesh. Cover 385 may be formed of any material that is thermally stable and chemically non-reactive, such as any material suitable for use in forming a substrate.

[0134] The microfluidic vaporizer 330 also includes a plurality of electrical connection pins 395 and necessary electrical wiring (not shown) to enable control of the heater 355 and any additional components of the microfluidic vaporizer that may require such control (e.g., valve 377). Any type of electrical contact may be utilized. The electrical connection pins 395 may be of a standard format to facilitate connection with additional devices, such as an aerosol delivery device. Referring to FIG. 2, for example, the microfluidic vaporizer 330 of FIG. 3 may include electrical contact pins 395 of a format that allows the microfluidic vaporizer to be plugged into the connection port 237. In this manner, the microfluidic vaporizer 330 may essentially be a plug-and-play device adapted to be inserted into the aerosol delivery device during aerosol formation and then removed and replaced. The engagement between the electrical contact pins 395 and the connection port 237 may be push / push or push / pull. In other embodiments, the microfluidic vaporizer 330 may be positioned within the aerosol delivery device such that it is not intended for removal or replacement. For example, the microfluidic vaporizer may be hard-wired to control components within the housing or may be included in a shell with an electrical connector, and the shell is not configured to be opened by the consumer (e.g., in cartridge shell 103 in FIG. 1).

[0135] A multi-layer microfluidic vaporizer 430 is shown in FIG. 4, in which a substrate 445 is formed of a base layer 448 and an intermediate layer 446. Both layers may be formed of materials as otherwise described above. A heater 455 is attached to the base layer 448 and corresponds to a first window 446a formed in the intermediate layer 446. A thermally conductive layer 447 is positioned within the first window 446a to prevent passage of liquid to the heater 455. A second window 446b is also formed in the intermediate layer 446, forming a reservoir 465 in which the aerosol precursor composition (or its components) can be stored. A plurality of capillary channels 475 are formed in the intermediate layer 446, providing fluid communication between the first window 446a and the second window 446b. When assembled, intermediate layer 446 contacts and is sealed, bonded, or otherwise connected to base layer 448 so that liquid stored in reservoir 465 formed by second window 446b and base layer 448 does not seep out from between the layers. Cover 485 is then draped over intermediate layer 446 to retain the liquid aerosol precursor composition within reservoir 465 and capillary channel 475. Microvalve 477 is positioned within capillary channel 475. Cover 485 includes microperforations such that at least a portion of the cover is vapor permeable but liquid impermeable.

[0136] Yet another embodiment of a microfluidic vaporizer 530 is shown in FIG. 5. As seen in its top view (with optional cover layers omitted for simplicity), a substrate 545 is provided with multiple reservoirs, a heater 555, a main capillary channel 575a, and multiple branch capillary channels 575b connecting each reservoir to the main capillary channel. By way of example, reservoirs 565a and 565b may be filled with an aerosol former composition (e.g., glycerin, propylene glycol, and water), reservoir 565c may be filled with a combination of nicotine and an aerosol former carrier, reservoirs 565d-565g may each be filled with a different flavor, and reservoir 565h may be filled with plain water. The use of multiple flavor reservoirs may allow for the use of smaller volumes of concentrated solutions. Multiple microvalves 577 are positioned in each of the branch capillary channels 575b.

[0137] In use, a microfluidic vaporizer 530 such as that shown in FIG. 5 can enable precise control of various flavor combinations. In some embodiments, when included in an aerosol delivery device, a user may use an input (see, e.g., touchscreen 209 shown in FIG. 2) to command the formation of an aerosol having a specific composition. For example, a user may input commands calling for the formation of an aerosol with a specific nicotine content (from 0% by weight to a predetermined threshold amount) and for the inclusion of a specific additional flavor. In such an example, the microfluidic vaporizer 530 would deliver the aerosol pharmaceutical from one or both of reservoirs 565a and 565b, the nicotine from reservoir 565c, and the requisite flavor from reservoirs 565d through 565g. During use of the aerosol delivery device (or during use of a particular microfluidic vaporizer), one combination may be selected, or a different combination of flavors (including nicotine content) may be indicated for each puff or any combination of puffs on an aerosol delivery device including a microfluidic vaporizer. If necessary, the user may instruct the microfluidic vaporizer 530 to deliver water from the reservoir 565h to the heater to remove previous flavors from the system and / or to clean the vaporizer flow path and / or heater area.

[0138] A further exemplary embodiment of a microfluidic vaporizer 630 is shown in FIG. 6. A substantially circular substrate 645 is provided with multiple reservoirs 665a-665f, multiple capillary channels 675a-675f, and a heater 655. In the exemplary embodiment, reservoirs 665a and 665b may be filled with an aerosol former composition (e.g., glycerin, propylene glycol, and water), reservoir 665c may be filled with a combination of nicotine and an aerosol former carrier, and reservoirs 665d-665f may each be filled with a different flavor. Any combination of aerosol former, nicotine, and additional flavors may be provided to heater 655 to form an aerosol of a particular desired composition. Active control of fluid delivery through capillary channels 675a-675f may be achieved using any method as otherwise described herein. Thus, the substrate 645 may include a microvalve, a micropump, or the like.

[0139] In some embodiments, a microfluidic vaporizer can include multiple heaters. For example, in the embodiment of FIG. 7, substrate 745 defines four heaters 755a-755d that are fluidly connected to four respective reservoirs 765a-765d via four respective capillary channels 775a-775d. In this embodiment, reservoir 765a contains a vapor former, reservoir 765b contains a nicotine composition, reservoir 765c contains a first additional flavor component, and reservoir 765d contains a second additional flavor component. In this manner, precise amounts of vapor former, nicotine, and additional flavor components can be delivered to their respective heaters to form a custom vapor. Although not shown in FIG. 7, it is understood that one or more active transport elements (e.g., microvalves or micropumps) can be included in any manner as otherwise described herein. Through the use of an input component (such as touchscreen 209 in FIG. 2 ), a consumer can define the exact amount of nicotine desired in a puff of the aerosol delivery device and the exact flavor intensity desired for that puff. Furthermore, because each component utilizes its own heater, the possibility of cross-flavoring from residue on the heater from a previous puff of a different flavor can be avoided. If multiple heaters are utilized, the heaters can be in parallel or in series. If multiple heaters are used, separate circuit components can also be utilized for the two or more heaters.

[0140] In the exemplary embodiments described above, the reservoir(s), capillary channel(s), and heater(s) are all formed directly in the substrate. In further embodiments, the capillary channel(s) and heater(s) may be defined by the substrate in that they extend outward from the substrate forming the reservoir. Thus, a microfluidic vaporizer may be characterized in that one or more capillary channels extend radially from the substrate. One or more heaters may also be located at the termini of the capillary channels.

[0141] FIG. 8 illustrates an embodiment of a microfluidic vaporizer 830 in which the substrate 845 is elongated and substantially in the form of a tube. While a tube having a circular cross section is shown, the substrate can assume any desired shape. The substrate 845 is preferably hollow to have a chamber formed therein, which is a reservoir 865 for storing the aerosol precursor composition. A plurality of heaters 855 are arranged radially around the substrate 845 and are fluidly connected to the reservoirs 865 therein via a plurality of capillary channels 875. During use, the aerosol precursor composition from the reservoirs 865 in the substrate 845 can pass through the capillary channels 875 to the heaters 855 located at the ends of the capillary channels. The heaters 855 can include at least one wall containing microperforations to allow vapor to pass therethrough but prevent liquid from passing therethrough.

[0142] 8 is substantially disc-shaped, although other shapes are also included. The heater can have a variety of configurations that cause the liquid aerosol precursor composition to pass through the capillary passage 875, come into heated contact with the heating element, and form a vapor that can escape from the heater.

[0143] One exemplary embodiment of a heater 955 that is substantially disk-shaped is shown in FIG. 9 . There, the heater 955 has a floor 981 through which a capillary flow path 975 a opens. The heater floor 981 may be formed of any thermally stable and chemically non-reactive material, as otherwise described herein. A capillary coil 975 b is interconnected with the capillary flow path 975 a so that liquid passes from the capillary flow path through the capillary coil. Beneath the capillary coil 975 b is a heating element 985 in heating arrangement with the capillary coil, so that liquid within the capillary coil can be vaporized. The heating element 985 may be formed of any material, as otherwise described herein, that is suitable for providing heating. For example, a printed heating element may be utilized. During use, a liquid aerosol precursor composition from a reservoir (see FIG. 8 ) passes through the capillary flow path 975 a and is then dispersed into the capillary coil 975 b. Upon heating of heating element 985, the liquid in capillary coil 975b vaporizes. A heater cover 988 may be positioned over the remaining elements of heater 955 to hold the liquid in capillary coil 975b until vaporization, at which point the vapor phase material may pass through the heater cover. Any cover construction may be utilized that is vapor permeable and liquid impermeable.

[0144] As another exemplary embodiment, the capillary coil 975b in Figure 9 may be replaced with multiple generally linear capillary channel branches extending radially from the open capillary channel 975a through the heater bed 981. The generally linear channel branches may be open at the periphery (or edge) 990 of the heater 955 to allow the formed vapor to escape therefrom. In such an embodiment, the heater cover 988 (or simply the top surface of the heater) may be solid rather than perforated. However, the periphery 990 of the heater 955 may be covered with a micro-perforated layer or similar material that is vapor-permeable and liquid-impermeable.

[0145] In embodiments such as that shown in Figure 8, multiple heaters 855 may be activated individually (e.g., activation of one heater results in a puff of aerosol). Alternatively, a combination of heaters 855 may be activated in near unison to result in a puff of aerosol. In further embodiments, substrate 845 may be divided into multiple reservoirs, which may hold the same or different compositions. In Figure 8, dashed line 866 indicates an optional embodiment in which substrate 845 is divided into four reservoirs, each having a set of radially extending capillary channels 875 and an associated heater 855.

[0146] Still other features, controls, or components that may be incorporated into the aerosol delivery systems of the present disclosure are described in U.S. Pat. No. 5,967,148 to Harris et al., U.S. Pat. No. 5,934,289 to Watkins et al., U.S. Pat. No. 5,954,979 to Counts et al., U.S. Pat. No. 6,040,560 to Fleischhauer et al., U.S. Pat. No. 8,365,742 to Hon, U.S. Pat. No. 8,402,976 to Fernando et al., and U.S. Patent Application Publication No. 2002 / 0026264, all of which are incorporated herein by reference. No. 010 / 0163063 to Tucker et al., U.S. Patent Application Publication No. 2013 / 0192623 to Leven et al., U.S. Patent Application Publication No. 2013 / 0298905 to Kim et al., U.S. Patent Application Publication No. 2013 / 0180553 to Sebastian et al., U.S. Patent Application Publication No. 2014 / 0000638 to Sebastian et al., U.S. Patent Application No. 13 / 840,264 to Novak et al., filed March 15, 2013, and U.S. Patent Application No. 13 / 841,233 to DePiano et al., filed March 15, 2013.

[0147] The foregoing description of the use of the article may be applied to the various embodiments described herein through minor modifications that may become apparent to those skilled in the art in light of the further disclosure provided herein. However, the foregoing description of the use is not intended to limit the use of the article, but is provided so as to fulfill all necessary disclosure requirements of the present disclosure. Many modifications and other embodiments of the present disclosure will come to mind to one skilled in the art to which this disclosure pertains having the benefit of the teachings presented in the foregoing Detailed Description and associated drawings. It is therefore to be understood that the present disclosure is not limited to the particular embodiments disclosed herein, and that modifications and other embodiments are intended to be included within the scope of the appended claims. Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. 1. A microfluidic vaporizer comprising: a substrate defining a reservoir configured to hold a liquid; a heater adapted to vaporize the liquid; and a capillary flow path configured for transfer of the liquid from the reservoir to the heater.

2. The microfluidic vaporizer of claim 1 , further comprising a cover covering the substrate.

3. The microfluidic vaporizer of claim 2 , wherein at least a portion of the cover is vapor permeable and liquid impermeable.

4. The microfluidic vaporizer of claim 1 , wherein the substrate is adapted for passive transfer of the liquid from the reservoir through the capillary channel to the heater.

5. 10. The microfluidic vaporizer of claim 1, further comprising an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimulus-responsive material, and combinations thereof.

6. 10. The microfluidic vaporizer of claim 1, wherein the liquid is an aerosol precursor composition, or a component thereof, suitable for use in an aerosol delivery device.

7. The microfluidic vaporizer of claim 1 , wherein the liquid comprises one or more flavors.

8. 8. The microfluidic vaporizer of claim 7, wherein the one or more flavors include nicotine.

9. The microfluidic vaporizer of claim 1 , wherein the liquid comprises an aerosol former.

10. 10. The microfluidic vaporizer of claim 9, wherein the aerosol former is selected from the group consisting of water, glycerin, propylene glycol, and combinations thereof.

11. The microfluidic vaporizer of claim 1 , wherein the substrate comprises a plurality of heaters.

12. The microfluidic vaporizer of claim 1 , wherein the substrate comprises a plurality of reservoirs.

13. 10. The microfluidic vaporizer of claim 1, comprising a first reservoir containing an aerosol former and a second reservoir containing one or more flavors.

14. 14. The microfluidic vaporizer of claim 13, wherein the first reservoir and the second reservoir are in fluid communication with the heater via the capillary channel.

15. 14. The microfluidic vaporizer of claim 13, wherein the first reservoir is in fluid communication with a first heater via a first capillary flow path, and the second reservoir is in fluid communication with a second heater via a second capillary flow path.

16. The microfluidic vaporizer of claim 1 , wherein the substrate further comprises one or more electrical connections.

17. The microfluidic vaporizer of claim 1 , wherein the reservoir and the capillary channel are etched into the substrate.

18. The microfluidic vaporizer of claim 1 , wherein the heater underlies at least a portion of the capillary channel.

19. The microfluidic vaporizer of claim 1 , comprising a plurality of capillary channels, the capillary channels extending radially from the substrate.

20. 20. The microfluidic vaporizer of claim 19, comprising a plurality of heaters positioned at the termini of the capillary channels.

21. The microfluidic vaporizer of claim 1 , wherein the substrate is substantially in the form of a chip.

22. The outer shell and 22. An aerosol delivery device comprising: a microfluidic vaporizer according to any one of claims 1 to 21.

23. The outer shell and 1. A microfluidic vaporizer comprising: substrate, a plurality of liquid flavor reservoirs formed in said substrate; a plurality of liquid flavors positioned within said liquid flavor reservoir; a liquid aerosol former reservoir formed in the substrate; a liquid aerosol former in said liquid aerosol former reservoir; heater, a plurality of capillary channels configured for transport of the liquid flavor and the liquid aerosol former to the heater; and An aerosol delivery device comprising: a microfluidic vaporizer comprising one or more electrical connections.

24. 24. The aerosol delivery device of claim 23, wherein the plurality of liquid flavors comprises nicotine.

25. 25. The aerosol delivery device of claim 24, wherein the nicotine is positioned in a first liquid flavor reservoir and at least one additional liquid flavor is positioned in a second liquid flavor reservoir.

26. 24. The aerosol delivery device of claim 23, wherein the device comprises multiple heaters.

27. 27. The aerosol delivery device of claim 26, wherein a first capillary flow path is configured for transfer of the liquid aerosol former to a first heater and a second capillary flow path is configured for transfer of at least one of the liquid flavors to a second heater.

28. 24. The aerosol delivery device of claim 23, wherein the separate liquid flavors are located in separate liquid flavor reservoirs.

29. 24. The aerosol delivery device of claim 23, wherein the microfluidic vaporizer further comprises a cover overlying the substrate.

30. 30. The aerosol delivery device of claim 29, wherein at least a portion of the cover is vapor permeable and liquid impermeable.

31. 24. The aerosol delivery device of claim 23, further comprising an active transport element selected from the group consisting of a valve, a pump, a heater, an electric field former, a stimulus-responsive material, and combinations thereof.

32. 32. The aerosol delivery device of any one of claims 22 to 31, further comprising a container in fluid communication with the microfluidic vaporizer, the container containing one or more aerosol precursor components.

33. 32. The aerosol delivery device of any one of claims 22 to 31, further comprising a microcontroller.

34. 34. The aerosol delivery device of claim 33, further comprising an input adapted to provide control instructions to the microcontroller.

35. 32. The aerosol delivery device of any one of claims 22 to 31, wherein the device comprises a first outer shell comprising the microfluidic vaporizer and a second outer shell comprising a power source.

36. 32. The aerosol delivery device of any one of claims 22 to 31, further comprising a mouthpiece.

37. 1. A method of forming an aerosol, comprising: Providing an aerosol delivery device according to any one of claims 22 to 36; delivering a control signal to the microfluidic vaporizer that causes a predetermined aliquot of at least one of the liquid aerosol former and the liquid flavor to move through the capillary channel to the heater; delivering a control signal to the microfluidic vaporizer that causes the heater to heat and vaporize the liquid aerosol former and the liquid flavor delivered to the heater.

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