Dermatological composition

Abstract

To provide a composition for skin not only exhibiting excellent preparation stability but also having good sense of use after application and capable of exhibiting sufficient moisturizing effect.SOLUTION: This composition for the skin is characterized by comprising the following components A, B, C and D: Ingredient A: coenzyme Q10 Ingredient B: fatty acid sterol ester Ingredient C: ether-type nonionic surfactant Ingredient D: polyhydric alcohol SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a dermatological composition. [Background technology]

[0002] Among various functional ingredients that exert moisturizing effects, coenzyme Q10 has recently attracted attention as an ingredient with exceptional moisturizing ability. However, while coenzyme Q10 can exert exceptionally excellent moisturizing effects, it has the drawback of easily causing precipitation and deteriorating formulation stability when incorporated at high concentrations in formulations.

[0003] For this reason, attempts have been made to impart stability to various formulations containing coenzyme Q10. Specific examples include a water-soluble composition containing a specific amount of coenzyme Q10, specific amounts of two polyglycerol fatty acid esters, and water (see, for example, Patent Document 1), an emulsified cosmetic containing coenzyme Q10, a water-soluble physiologically active substance, and a specific oil (see, for example, Patent Document 2), an emulsified composition containing coenzyme Q10, a specific amount of a medium-chain triglyceride, a surfactant, a polyhydric alcohol, and a specific amount of water (see, for example, Patent Document 3), a water-soluble product containing coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester, and an aqueous phase component (see, for example, Patent Document 4), and an emulsion composition containing coenzyme Q10, a phospholipid, a polyglycerol fatty acid ester, and a polyhydric alcohol (see, for example, Patent Document 5).

[0004] However, although these attempts can impart formulation stability, they only solve the formulation instability in specific formulations, and are not technologies that can be adapted or applied to skin care agents in various formulations such as liquids, gels, emulsions, creams, etc. Furthermore, since most of these attempts are technologies that focus on imparting formulation stability, they are not fully satisfactory in terms of the sensation of use after application, such as non-stickiness and moisturizing. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2004-196781 [Patent Document 2] Japanese Patent Application Laid-Open No. 2006-143656 [Patent Document 3] International Publication No. 2006 / 035900 [Patent Document 4] International Publication No. 2006 / 134970 [Patent Document 5] Japanese Patent Application Laid-Open No. 2008-239580 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention has been made in view of the above-mentioned conventional technology, and aims to provide a skin composition that is a technology applicable to skin care agents of various dosage forms, and that not only exhibits excellent formulation stability but also provides a good feeling after application and a sufficient moisturizing effect. [Means for solving the problem]

[0007] That is, the skin composition of the present invention is characterized by containing Component A: coenzyme Q10, Component B: fatty acid sterol ester, Component C: ether-type nonionic surfactant, and Component D: polyhydric alcohol.

[0008] The component B is preferably at least one selected from phytosteryl isostearate, phytosteryl macadamiate, and phytosteryl oleate.

[0009] The ratio of the content of the component B to the content of the component A (component B / component A) preferably falls within the range of 1 / 10 to 10 / 1.

[0010] The component C is preferably a polyoxyethylene polyoxypropylene alkyl ether.

[0011] The content of the component D is preferably 5 to 30% by mass.

[0012] Furthermore, it is preferable to contain component E: at least one selected from nicotinic acid and / or its derivatives, hyaluronic acid and / or its derivatives, collagen and / or its derivatives, and phospholipids. [Effects of the Invention]

[0013] By satisfying the above-mentioned constituent requirements, the skin composition of the present invention has the effect of exhibiting excellent formulation stability (preservation stability of the formulation) without precipitation due to coenzyme Q10 in various formulations, such as liquid, gel, or emulsion formulations, which contain coenzyme Q10 and which may cause deterioration in formulation stability.

[0014] Furthermore, the skin composition of the present invention has the effect of being able to impart a significantly superior moisturizing effect while being less sticky after application and providing a good feel in use. DETAILED DESCRIPTION OF THE INVENTION

[0015] The skin composition of the present invention contains Component A: coenzyme Q10, Component B: fatty acid sterol ester, Component C: ether-type nonionic surfactant, and Component D: polyhydric alcohol.

[0016] Each component used in the skin composition of the present invention will be described in detail below.

[0017] [Component A] The above-mentioned component A is coenzyme Q10. Coenzyme Q10 is a compound also known as coenzyme Q10, CoQ10, ubiquinone, or ubidecarenone. In the present invention, the use of the above-mentioned component A can impart an excellent moisturizing effect.

[0018] In the present invention, commercially available coenzyme Q10 can be used. The commercially available coenzyme Q10 may be a single ingredient or a mixture with other ingredients, as long as it exerts the desired effect.

[0019] The content of component A in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of exhibiting a significantly superior moisturizing effect, it is usually preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and even more preferably more than 0.3% by mass, based on 100% by mass of the composition. Furthermore, from the viewpoint of suppressing precipitation and improving the feeling of use after application, it is preferably 1% by mass or less, more preferably 0.9% by mass or less, based on 100% by mass of the composition. Note that the content of component A above is the amount converted to pure content.

[0020] In the present invention, even if the above-mentioned component A is incorporated at a high level, specifically, even if it is incorporated at a level greater than 0.3 mass %, by combining it with the components described below, it is possible to obtain a skin composition that has good formulation stability and is significantly superior in terms of usability and moisturizing effect.

[0021] [Component B] Component B is a fatty acid sterol ester. In the present invention, by using component B, it is possible to suppress precipitation caused by component A, and to exert an excellent effect on formulation stability (preservation stability of the formulation).

[0022] Examples of component B include fatty acid phytosterol esters, fatty acid cholesterol esters, etc. The number of carbon atoms in the fatty acid constituting the fatty acid sterol ester of component B is not particularly limited, but is preferably 8 to 24, and more preferably 10 to 22. The fatty acid moiety is not particularly limited, and may be either saturated or unsaturated, as long as the desired effect is sufficiently exhibited.

[0023] In this specification, the fatty acid phytosterol ester may be referred to as "component B1," and the fatty acid cholesterol ester may be referred to as "component B2."

[0024] Specific examples of component B1 include lanolin fatty acid phytosteryl, phytosteryl oleate, dihydrophytosteryl oleate, phytosteryl hydroxystearate, phytosteryl isostearate, N-lauroyl-L-glutamic acid di(octyldodecyl / phytosteryl / behenyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, rice bran oil fatty acid phytosteryl, dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), etc. These components B1 may be used alone or in appropriate combination of two or more.

[0025] Specific examples of component B2 include lanolin fatty acid cholesteryl, cholesteryl oleate, dihydrocholesteryl oleate, cholesteryl hydroxystearate, cholesteryl isostearate, di(cholesteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, di(cholesteryl / octyldodecyl) N-lauroyl-L-glutamate, cholesteryl macadamia nut oil fatty acid, cholesteryl sunflower seed oil fatty acid, cholesteryl rice bran oil fatty acid, etc. These components B2 may be used alone or in appropriate combination of two or more.

[0026] Among the above-mentioned component B, it is preferable to use fatty acid phytosterol esters, from the viewpoint of exhibiting excellent effects on formulation stability, and it is more preferable to use at least one selected from phytosteryl isostearate, phytosteryl macadamia nut oil fatty acid, and phytosteryl oleate.

[0027] In the present invention, a commercially available product can be used as the above-mentioned component B. The commercially available product of component B may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0028] The content of component B in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of imparting formulation stability, it is usually preferably 0.1% by mass or more, more preferably 0.3% by mass or more, based on 100% by mass of the composition. Furthermore, from the viewpoint of usability, it is preferably 3% by mass or less, more preferably 1.5% by mass or less, based on 100% by mass of the composition. The content of component B above is the amount converted to a pure content. It also refers to the total amount of component B blended in the skin composition of the present invention.

[0029] In the present invention, from the viewpoint of suppressing precipitation of the component A and imparting significantly superior formulation stability, the ratio of the content of the component B to the component A (component B / component A) preferably falls within the range of 1 / 10 to 10 / 1, more preferably falls within the range of 1 / 7 to 7 / 1, and even more preferably falls within the range of 1 / 5 to 5 / 1. When the skin composition of the present invention is prepared so that these content ratios are satisfied, it becomes possible to exhibit exceptionally remarkable formulation stability.

[0030] [Component C] Component C is an ether-type nonionic surfactant. In the present invention, the use of component C can further improve the formulation stability. It also reduces stickiness after application, making it possible to achieve a good feel when used. Examples of component C include polyoxyethylene alkyl ether and polyoxyethylene polyoxypropylene alkyl ether.

[0031] The number of carbon atoms in the alkyl group constituting the ether-type nonionic surfactant of Component C is not particularly limited, but is preferably 8 to 24, and more preferably 10 to 22. In addition, the alkyl group is not particularly limited, and may be a linear alkyl group or a branched alkyl group, as long as the desired effect is sufficiently exhibited.

[0032] In this specification, the polyoxyethylene alkyl ether may be referred to as "component C1," and the polyoxyethylene polyoxypropylene alkyl ether may be referred to as "component C2."

[0033] Specific examples of the component C1 include polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene isostearyl ether, polyoxyethylene oleyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene behenyl ether, polyoxyethylene alkyl (12-14) ether, etc. One of these components C1 may be used alone, or two or more may be used in appropriate combination.

[0034] The average number of moles of oxyethylene groups (ethylene oxide) added that constitute the above component C1 is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of improving the formulation stability, it is preferably 5 to 30, more preferably 10 to 25.

[0035] Specific examples of the component C2 include polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene stearyl ether, polyoxyethylene polyoxypropylene decyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, etc. One of these components C2 may be used alone, or two or more may be used in appropriate combination.

[0036] The average number of moles of oxyethylene groups (ethylene oxide) added that constitute component C2 is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of enhancing formulation stability, it is preferably 2 to 35, more preferably 3 to 30. Furthermore, the average number of moles of oxypropylene groups (propylene oxide) added that constitute component C2 is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of enhancing formulation stability, it is preferably 2 to 10, more preferably 4 to 8.

[0037] Among the above-mentioned component C, polyoxyethylene polyoxypropylene alkyl ethers are preferably used from the viewpoint of exhibiting excellent effects on formulation stability, and it is more preferable to use at least one selected from polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) polyoxypropylene (8) cetyl ether, polyoxyethylene (12) polyoxypropylene (6) decyltetradecyl ether, polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, and polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether. The integer in the parentheses indicates the average number of moles of oxyethylene groups (ethylene oxide) and oxypropylene groups (propylene oxide) added.

[0038] In the present invention, a commercially available product can be used as the above-mentioned component C. The commercially available product of component C may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0039] The content of component C in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of imparting formulation stability and improving the feeling of use, it is usually preferably 0.1% by mass or more, more preferably 0.2% by mass or more, based on 100% by mass of the composition. Furthermore, from the viewpoint of preventing deterioration of the feeling of use, it is preferably 2% by mass or less, more preferably 1% by mass or less, based on 100% by mass of the composition. Note that the content of component C above is the amount converted to a pure content. It also refers to the total amount of component C blended in the skin composition of the present invention.

[0040] [Component D] Component D is a polyhydric alcohol. In the present invention, by using component D, the precipitation-inhibiting effect of component A is enhanced, and excellent formulation stability can be achieved. In addition, stickiness after application can be suppressed, improving the moisturizing effect. Examples of component D include dihydric alcohols and trihydric or higher alcohols.

[0041] In this specification, the dihydric alcohol may be referred to as "component D1," and the trihydric or higher alcohol may be referred to as "component D2."

[0042] The component D1 is a general term for alcohols in which two hydrogen atoms of a hydrocarbon have been substituted with hydroxyl groups. Specific examples of the component D1 include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, isoprene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,2-dodecanediol, polyethylene glycol, and polypropylene glycol. One type of component D1 may be used alone, or two or more types may be used in appropriate combination.

[0043] The component D2 is a general term for alcohols in which three or more hydrogen atoms of a hydrocarbon have been substituted with hydroxyl groups. Specific examples of the component D2 include glycerin (concentrated glycerin), diglycerin, triglycerin, polyglycerin, 1,2,4-butanetriol, glucose, maltose, maltitol, sucrose, mannitol, sorbitol, xylitol, erythritol, trehalose, and glucosyltrehalose. One type of component D2 may be used alone, or two or more types may be used in appropriate combination.

[0044] Of the above-mentioned component D, from the viewpoint of enhancing the precipitation-inhibiting effect of component A, enhancing the stability of the formulation, and further improving the moisturizing effect, it is preferable to use propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, glycerin (concentrated glycerin), diglycerin, polyglycerin, sorbitol, trehalose, or glucosyl trehalose, and it is more preferable to use dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, glycerin (concentrated glycerin), diglycerin, or polyglycerin.

[0045] In the present invention, a commercially available product can be used as the component D. The commercially available product of component D may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0046] The content of component D in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoints of enhancing the precipitation-inhibiting effect of component A, enhancing formulation stability, and further improving the moisturizing effect, it is generally preferably 5% by mass or more, more preferably 8% by mass or more, based on 100% by mass of the composition. Furthermore, from the viewpoint of suppressing deterioration of the feel during use, such as stickiness, it is preferably 30% by mass or less, more preferably 20% by mass or less, based on 100% by mass of the composition. The content of component D is the amount converted to a pure content. It also refers to the total amount of component D blended in the skin composition of the present invention.

[0047] By combining the above components, the skin composition of the present invention can be endowed with significantly superior formulation stability and can exhibit a good feel when used, and therefore, component E, which can improve the moisturizing effect, can be blended into the skin composition of the present invention.

[0048] [Component E] The component E is at least one selected from nicotinic acid and / or its derivatives, hyaluronic acid and / or its derivatives, collagen and / or its derivatives, and phospholipids. In this specification, the nicotinic acid and / or its derivatives may be referred to as "component E1," the hyaluronic acid and / or its derivatives as "component E2," the collagen and / or its derivatives as "component E3," and the phospholipids as "component E4."

[0049] Specific examples of component E1 include nicotinic acid, methyl nicotinate, ethyl nicotinate, n-butyl nicotinate, benzyl nicotinate, phenyl nicotinate, sodium nicotinate, nicotinamide, nicotinic acid hydrazide, (±)-α-tocopherol nicotinate, etc. These components E1 may be used alone or in appropriate combination of two or more.

[0050] Specific examples of component E2 include hyaluronic acid, hydrolyzed hyaluronic acid, sodium hyaluronate, acetylated hyaluronic acid, propylene glycol hyaluronate, etc. These components E2 may be used alone or in appropriate combination of two or more.

[0051] Specific examples of component E3 include water-soluble collagen, hydrolyzed collagen, atelocollagen, acylated collagen, succinylated atelocollagen, etc. One of these components E3 may be used alone, or two or more may be used in appropriate combination.

[0052] Specific examples of component E4 include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin, and soybean lecithin; synthetic phospholipids such as dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dioleoylphosphatidylcholine, and palmitoyl-oleoylphosphatidylcholine; and hydrogenated phospholipids such as hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine, and hydrogenated phosphatidylserine. These component E4s may be used alone or in appropriate combinations of two or more.

[0053] In the present invention, a commercially available product can be used as the above-mentioned component E. The commercially available product of component E may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0054] The content of component E in the skin composition of the present invention is not particularly limited as long as the desired effect is sufficiently exhibited, but from the viewpoint of improving the moisturizing effect, it is usually preferably 0.001% by mass or more, more preferably 0.01% by mass or more, based on 100% by mass of the composition. Furthermore, from the viewpoint of suppressing deterioration of the feeling in use, such as stickiness, it is preferably 10% by mass or less, more preferably 5% by mass or less, based on 100% by mass of the composition. The content of component E above is the amount converted to a pure content. It also refers to the total amount of component E blended in the skin composition of the present invention.

[0055] [Other ingredients] The skin composition of the present invention can be prepared into various dosage forms such as liquid, gel, emulsion, and cream, and can contain, in addition to the above-mentioned components, oils such as fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, fatty acid ester oils other than component B above, and silicone oil; surfactants such as anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants other than component C above; thickening polymers, film-forming agents, ultraviolet absorbers, preservatives, whitening agents, anti-inflammatory agents, cooling agents, plant extracts, plant fermentation extracts, pH adjusters, neutralizing agents, fragrances, and the like, as appropriate depending on the purpose, so long as the effects of the present invention are not impaired.

[0056] The remainder of the skin composition of the present invention is made up of purified water. The content of purified water is not particularly limited as long as it is an amount that allows preparation into various dosage forms such as liquid, gel, emulsion, and cream, but is preferably 50 to 95% by mass.

[0057] In the present invention, by satisfying the above-mentioned constituent components, transparency can be maintained without precipitation caused by the above-mentioned component A, and therefore, when the skin composition of the present invention is in a liquid or gel form that presents a transparent appearance, it can exhibit excellent aesthetic effects. Note that, in the present invention, "transparent" refers to an appearance that is not cloudy.

[0058] The method for producing the skin composition of the present invention is not particularly limited, and the composition can be produced by, for example, a known method. Specific examples include a method of mixing the above-mentioned components using a known mixing device such as a disper mixer or a paddle mixer, or a method of emulsifying the composition by a phase inversion emulsification method using a homomixer, but the present invention is not limited to these production methods.

[0059] The use of the skin composition according to one embodiment of the present invention is not particularly limited, but it is preferably used as a skin cosmetic, and more specifically, it is preferably used, for example, as a moisturizing cosmetic, a whitening cosmetic, an acne care cosmetic, or an anti-aging cosmetic intended to inhibit wrinkles, inhibit sagging, etc. Furthermore, the skin composition of the present invention may take the form of a cosmetic, a quasi-drug, a designated quasi-drug, miscellaneous goods, etc.

[0060] Furthermore, the area to which the skin composition according to one embodiment of the present invention is applied is not particularly limited, but examples include the face (forehead, eyes, corners of the eyes, cheeks, mouth, etc.), arms, elbows, backs of hands, fingertips, feet, knees, heels, neck, décolleté, armpits, and back. [Example]

[0061] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples. The blending amounts are expressed in "% by mass" unless otherwise specified.

[0062] In the following evaluation tests 1 and 2, a liquid dosage form was used to enable a clearer determination of the presence or absence of precipitation due to coenzyme Q10 in ingredient A.

[0063] (Sample preparation 1) Skin compositions of Examples 1 to 7 and Comparative Examples 1 to 5 were prepared in accordance with standard methods according to the formulations shown in Tables 1 and 2, and were subjected to the following evaluations. The results are also shown in Tables 1 and 2. The blend amounts in the tables are all values ​​converted to pure components.

[0064] Test Example 1: Evaluation of formulation stability Each sample of the Examples and Comparative Examples was sealed in a 50 mL transparent glass container and stored in a thermostatic chamber at 0° C. for 4 weeks. Thereafter, the appearance was visually observed and evaluated according to the following evaluation criteria.

[0065] <Evaluation criteria for formulation stability> ○ (Good): No precipitates due to coenzyme Q10 were observed. △ (insufficient): A slight amount of precipitate due to coenzyme Q10 is observed × (bad): Precipitates caused by coenzyme Q10 are clearly observed

[0066] (Test Example 2: Evaluation after application) Approximately 1 g of each sample from the Examples and Comparative Examples was placed in the palm of the hand and applied to both cheeks. 30 minutes after application, a sensory evaluation was conducted on the "stickiness" and "moisturization" of the applied area, and the results were judged according to the following evaluation criteria. The evaluation was carried out by 10 expert evaluators at 25°C, and the overall evaluation of each evaluator was used to determine the results. In addition, for those in Test Example 1 whose formulation stability evaluation result was "× (poor)", no evaluation was conducted after application.

[0067] <Evaluation criteria for stickiness after application> ○ (Good): No stickiness at all, good usability △ (Unsatisfactory): Slight stickiness is felt, and it cannot be said that the feeling of use is good. × (bad): Clearly sticky and uncomfortable to use

[0068] <Evaluation criteria for moisturizing feeling after application (moisturizing effect)> ○ (Good): Feels moist and hydrated (moisturizing effect) △ (Insufficient): Moisture (moisturizing effect) is slightly felt, but it cannot be said to be good. × (bad): No moisturizing effect at all

[0069] [Table 1]

[0070] [Table 2]

[0071] The results shown in Tables 1 and 2 indicate that the skin compositions obtained in each Example exhibit significantly superior formulation stability compared to those obtained in each Comparative Example. In particular, even in formulations containing a high concentration of coenzyme Q10, no precipitation due to coenzyme Q10 occurs, and formulation stability is maintained. Furthermore, the skin compositions obtained in each Example exhibit reduced stickiness after application, a good feel during use, and excellent moisturizing effects.

[0072] A gel-type skin composition of Example 8 was prepared by a conventional method according to the following formulation and subjected to the same evaluation tests as in Test Example 1. Unless otherwise specified, the blend amounts are expressed in "% by mass." All blended components were converted to pure contents.

[0073] (Example 8: Gel-type skin composition) (% by mass) Carboxyvinyl polymer 0.4 Sodium hyaluronate 0.1 Water-soluble collagen 0.01 Glycerin 5.0 Diglycerin 1.0 Trehalose 2.0 1,3-butylene glycol 10.0 1,2-Pentanediol 2.0 Methylparaben 0.2 Coenzyme Q10 (ubidecarenone) 0.6 Squalane 0.3 Phytosteryl Isostearate 0.3 Tocopherol 0.02 Polyglyceryl-10 Oleate 0.5 Polyoxyethylene (20) Polyoxypropylene (4) Cetyl Ether 0.6 Polyoxyethylene (20) Polyoxypropylene (8) Cetyl Ether 0.1 Potassium hydroxide 0.2 Refined water residue Total 100.0

[0074] The gel-type skin composition of Example 8 was formulated with a high concentration of coenzyme Q10, but did not exhibit precipitation due to coenzyme Q10, and demonstrated significantly superior formulation stability.

[0075] An emulsion-type skin composition of Example 9 was prepared by a conventional method according to the following formulation, and evaluated according to the same evaluation criteria as in Test Example 1 above, except that the composition was taken out on the back of the hand and checked for the presence or absence of precipitates. Unless otherwise specified, the blend amounts are expressed in "% by mass." Furthermore, all blended components were converted to pure contents.

[0076] Example 9: Emulsion-like skin composition (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.3 Xanthan gum 0.1 Water-soluble collagen 0.01 Sodium hyaluronate 0.02 Glycerin 10.0 Sorbitol 2.0 Hydrogenated lecithin 0.5 1,3-butylene glycol 12.0 Dipropylene Glycol 3.0 Phenoxyethanol 0.4 Coenzyme Q10 (ubidecarenone) 0.6 Squalane 3.0 Sunflower seed oil 1.0 Phytosteryl Isostearate 0.25 Macadamia nut oil fatty acid phytosteryl 0.25 Tocopherol 0.05 Polyoxyethylene (20) Polyoxypropylene (4) Cetyl Ether 0.4 Polyoxyethylene (30) Polyoxypropylene (6) Decyl tetradecyl ether 0.2 Potassium hydroxide 0.15 Refined water residue Total 100.0

[0077] The emulsion-type skin composition of Example 9, despite being formulated with a high amount of coenzyme Q10, did not exhibit precipitation due to coenzyme Q10, and demonstrated significantly superior effects in formulation stability.

Claims

1. A skin composition comprising the following components A, B, C, and D: Component A: Coenzyme Q10 Component B: fatty acid sterol ester Component C: Ether-type nonionic surfactant Component D: Polyhydric alcohol

2. 2. The skin composition according to claim 1, wherein said component B is at least one selected from the group consisting of phytosteryl isostearate, phytosteryl macadamiate, and phytosteryl oleate.

3. 3. The skin composition according to claim 1, wherein the ratio of the content of component B to the content of component A (component B / component A) is in the range of 1 / 10 to 10 / 1.

4. The skin composition according to any one of claims 1 to 3, wherein the component C is a polyoxyethylene polyoxypropylene alkyl ether.

5. The composition for skin according to any one of claims 1 to 4, wherein the content of component D is 5 to 30 mass%.

6. The composition for skin according to any one of claims 1 to 5, further comprising the following component E: Component E: At least one selected from nicotinic acid and / or its derivatives, hyaluronic acid and / or its derivatives, collagen and / or its derivatives, and phospholipids

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