Oral composition

Abstract

To provide a composition for the oral cavity having excellent balance between squeezing properties in squeezing the composition from a tube container and cushioning properties in brushing teeth.SOLUTION: An oral composition comprising a polishing agent and a binder, wherein (3mm) * (TF10) is 50 (gf) {circumflex over ()} 2 or more and less than 5000 (gf) {circumflex over ()} 2, and PF3 is 4. TF5 or more and TF10 or less, where TF5 is a maximum pushing force in a 10mm pushing test, is a tensile stress in a PF3 tensile test, and is a tensile stress in a tensile test. 0gf 50gf 5mm.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Patent Document 1 (JP 2021-91654 A) describes a technology for improving the dischargeability of oral compositions from their storage containers. This document describes a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound (Claim 1). According to this document, a dentifrice composition can be provided that has the effects of the water-soluble polyvalent metal salt, such as suppressing hypersensitivity, suppressing bad breath, and tightening the gums, and that is easy to mold and apply to a toothbrush. It also exhibits reduced hardening over time, allowing for easy discharge from the storage container even after storage. The document also describes a dentifrice composition that maintains satisfactory physical properties and can be formulated into a dentifrice composition with a relatively low or no abrasive content, ensuring a gentle, low-irritation brushing experience. It is particularly useful for suppressing hypersensitivity or bad breath and tightening the gums (paragraph 0011). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent Publication No. 2021-91654 DISCLOSURE OF THE INVENTION [Problem to be solved by the invention]

[0004] Through the investigations of the present inventors, it became clear that there is room for improvement in the product described in Patent Document 1 above in terms of improving the ease of squeezing it out of the tube container while also improving the cushioning effect when brushing teeth.

[0005] The present invention provides an oral composition that has an excellent balance between squeezability when squeezed out of a tube container and cushioning properties when brushing teeth. [Means for solving the problem]

[0006] According to the present invention, the following oral compositions are provided. [1] An oral composition comprising an abrasive and a binder, When the maximum pushing stress in the 3 mm push-in test measured by the following method 1 is defined as PF3, and the pulling stress in the 5 mm tensile test and the 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively, (PF3)*(TF5) is 50(gf)^2 or more and less than 5000(gf)^2, An oral composition having a TF10 of 4.0 gf or more and 50 gf or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pushed to the pushing distance at the measuring speed, and the maximum stress during pushing is measured. The average value of three measurements is taken as the PF3. (Method 2) Device name: Rheometer Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The oral composition is filled into the container until it is full, and after setting it in the device, it is pulled up at the measurement speed and the absolute value of the stress at each pulling distance is measured. The average value of three measurements at each pulling distance is designated as the TF5 or TF10. [2] The oral composition according to [1], wherein the binder contains thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The oral composition described in [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan). [5] An oral composition according to any one of [1] to [4], wherein the abrasive comprises abrasive silica. [6] An oral composition described in any one of [1] to [5], further comprising a humectant. [7] An oral composition described in any one of [1] to [6], which is a dentifrice composition. [8] The oral composition according to any one of [1] to [7], which is a toothpaste composition. [9] A dentifrice in which the oral composition described in any one of [1] to [8] is filled in a tube container.

[0007] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention. [Effects of the Invention]

[0008] According to the present invention, an oral composition can be obtained that has an excellent balance between ease of squeezing from a tube container and cushioning properties during tooth brushing. DETAILED DESCRIPTION OF THE INVENTION

[0009] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component either alone or in combination of two or more. In this specification, the symbol "to" indicating a numerical range means "greater than or equal to" or "less than or equal to," and both of the numerical values ​​at both ends are included.

[0010] (Oral composition) In this embodiment, the oral composition contains an abrasive and a binder, and when the maximum compressive stress in a 3 mm indentation test measured by the following method 1 is defined as PF3, and the tensile stresses in a 5 mm tensile test and a 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively, (PF3)*(TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, and TF10 is 4.0 gf or more and 50 gf or less.

[0011] (Method 1) Device name: Rheometer (e.g., CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: Fill the filling container with oral composition until it is full, set it in the device, and then push it to the pushing distance at the measuring speed, and measure the maximum stress during pushing. The average value of three measurements is taken as PF3.

[0012] (Method 2) Device name: Rheometer (e.g., CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: Fill the container with oral composition until it is full, set it in the device, and then lift it up at the measurement speed. Measure the absolute value of the stress at each lifting distance. Measure three times at each lifting distance and the average value is TF5 or TF10. In the procedure of Method 2, the numerical value of the stress during pulling is a negative value, so the recorded value is a negative value and the absolute value is a positive value.

[0013] Here, the measurement temperature in Measurement 1 and Measurement 2 is specifically room temperature (25° C.).

[0014] The present inventors have investigated the ingredients and physical properties of oral compositions as design guidelines for improving the balance between the ease of squeezing the composition from a tube filled in the tube and the cushioning effect it provides during tooth brushing. As a result, they have newly discovered that by controlling the ingredients of the oral composition and using (PF3)*(TF5) and TF10 as indicators, it is possible to make the oral composition filled in the tube easier to squeeze from the tube, while also providing suitable cushioning effect on the surfaces of the teeth and gums during tooth brushing, thereby achieving a favorable balance between these effects. That is, in this embodiment, the oral composition contains a combination of an abrasive and a binder, and (PF3)*(TF5) and TF10 are each within a specific range, resulting in an excellent balance between the ease of squeezing the composition from a tube container and cushioning properties during toothbrushing. This also makes it possible to obtain an oral composition that is easy to handle and has a pleasant feel in the oral cavity. For example, it is possible to reduce the feeling of excessive hardness when squeezing the oral composition from a tube container and to suitably reduce dripping from the nozzle. It is also possible to improve the controllability of the amount of oral composition dispensed from a tube container. Furthermore, for example, when using the oral composition with a toothbrush, it is possible to provide a moderate massaging sensation with the toothbrush while reducing irritation.

[0015] The product of the maximum pushing stress PF3 in a 3 mm pushing test and the pulling stress TF5 in a 5 mm pulling test, i.e., (PF3)*(TF5), is 50 (gf)^2 or more, preferably 80 (gf)^2 or more, more preferably 100 (gf)^2 or more, even more preferably 150 (gf)^2 or more, and even more preferably 200 (gf)^2 or more. This can reduce dripping of the oral composition filled in the tube container from the discharge outlet. It can also provide more preferable cushioning properties during tooth brushing. It can also provide a more preferable massage feeling when using a toothbrush. The product of the stresses (PF3) * (TF5) is less than 5000 (gf)^2, preferably 4000 (gf)^2 or less, more preferably 3000 (gf)^2 or less, even more preferably 2500 (gf)^2 or less, still more preferably 2000 (gf)^2 or less, and may be 1000 (gf)^2 or less. This reduces the feeling of excessive hardness when squeezing the oral composition filled in the tube container. Furthermore, the oral composition can be easily spread in the oral cavity.

[0016] PF3 is preferably 10 gf or more, more preferably 20 gf or more, even more preferably 30 gf or more, and even more preferably 40 gf or more, which allows for more preferable sharpness when the oral composition filled in the tube container is discharged. Furthermore, PF3 is preferably 130 gf or less, more preferably 100 gf or less, even more preferably 80 gf or less, and even more preferably 60 gf or less. This can further improve the dischargeability when squeezing the oral composition filled in the tube container. Also, it can improve the usability of the oral composition.

[0017] TF5 can be set to a value such that (PF3)*(TF5) falls within the above-mentioned range. TF5 may be, for example, 7 g or more, or may be, for example, 40 g or less.

[0018] The tensile stress TF10 in a 10 mm tensile test is 4.0 gf or more, preferably 5.0 gf or more, and more preferably 6.0 gf or more. This improves cushioning during tooth brushing and also provides a more pleasant massage feeling during tooth brushing. The TF10 is 50 gf or less, preferably 40 gf or less, more preferably 35 gf or less, even more preferably 30 gf or less, even more preferably 25 gf or less, and even more preferably 20 gf or less. This improves cushioning properties during tooth brushing. Furthermore, when the oral composition is used with a toothbrush, the irritation caused by the toothbrush can be reduced.

[0019] Next, the components of the oral composition will be described. The oral composition includes an abrasive and a binder as described above.

[0020] (abrasive) Examples of abrasives include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel-process silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolite; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, and quaternary calcium phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0021] The abrasive preferably contains abrasive silica, more preferably hydrated silicic acid. It is also preferable that the abrasive contains anhydrous silicic acid. This allows for a more stable improvement in the balance between the ease of squeezing the powder from the tube container and the cushioning effect during tooth brushing. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0022] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, even more preferably 5 μm or more, and even more preferably 8 μm or more, which allows for efficient removal of stains from the tooth surface. The average particle size of the abrasive silica is preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less, thereby making it possible to obtain an oral composition that is smooth to the touch.

[0023] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering particle size distribution analyzer. 50 It can be said that:

[0024] It is also preferable that the abrasive is substantially free of calcium carbonate, which allows for a more stable and improved balance between the ease of squeezing the abrasive from the tube container and the cushioning effect during tooth brushing. Here, the oral composition not containing calcium carbonate specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001% by mass or less of the entire oral composition.

[0025] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably more than 10% by mass, still more preferably more than 10% by mass, even more preferably more than 11% by mass, and still more preferably more than 13% by mass, based on the total mass of the oral composition. This allows for efficient removal of stains from tooth surfaces. The content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total mass of the oral composition, thereby providing an oral composition with excellent smoothness in use.

[0026] (binder) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel-process silica, precipitated silica) and anhydrous silicic acid (e.g., gel-process silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0027] The binder preferably contains an inorganic binder, more preferably contains thickening silica, which can more stably improve the balance between the squeezability when squeezed out of the tube container and the cushioning effect when brushing teeth.

[0028] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica. The average particle size of the thickening silica is, for example, preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more, which allows the viscosity of the oral composition to be maintained more efficiently. The average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less, thereby making it possible to obtain an oral composition that is excellent in smoothness when used.

[0029] The oil absorption of the thickening silica, determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0030] The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This allows for an oral composition with superior cushioning properties during tooth brushing. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc. The content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total mass of the oral composition, thereby enabling the production of an oral composition with excellent surface smoothness.

[0031] The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between the ease of squeezing the powder from the tube container and the cushioning effect when brushing teeth.

[0032] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); More preferably, it contains one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; More preferably, the compound contains two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; Even more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; Even more preferably, it contains sodium alginate and xanthan gum. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0033] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition does not contain xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

[0034] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total mass of the oral composition, which allows the oral composition to have an appropriate viscosity. The content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total mass of the oral composition, thereby enabling the oral composition to be easily squeezed out of the tube container.

[0035] The mass ratio of the organic binder content to the inorganic binder content in the oral composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more, thereby making it possible to obtain an oral composition that is smooth to the touch and has an excellent feel when used. The mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less, thereby providing an oral composition that is easy to dispense from the tube container onto a toothbrush or the like. The total content of the binder in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition, which allows the oral composition to have an appropriate viscosity. The total content of the binder in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows for an oral composition that is more easily absorbed by saliva during tooth brushing. Furthermore, excessive thickening of the oral composition can be suppressed.

[0036] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total mass of the oral composition, thereby making it possible to appropriately suppress the fluidity of the oral composition. The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition, which allows for an oral composition that is more easily mixed with saliva in the oral cavity, for example, during tooth brushing.

[0037] (Other ingredients) The oral composition may further contain ingredients other than those mentioned above, such as medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., which may be selected appropriately depending on the dosage form.

[0038] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0039] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0040] Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0041] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0042] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0043] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0044] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0045] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0046] An example of a plaque decomposing enzyme is dextranase.

[0047] The thickening agent may be, for example, a commercially available ingredient for pharmaceuticals, foods, or cosmetics. The thickening agent may include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically, sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactite, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0048] Examples of surfactants include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; Nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and Examples thereof include one or more selected from the group consisting of amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amide alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may be a foaming agent.

[0049] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total mass of the oral composition, thereby providing an oral composition that foams appropriately when brushing teeth. The content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total mass of the oral composition, thereby providing an oral composition with cleansing power that does not excessively remove oil from the oral cavity.

[0050] The oral composition preferably further comprises a humectant, which can provide the oral composition with better manufacturing stability. The humectant may be any commercially available ingredient for pharmaceuticals, foods, or cosmetics, such as polyhydric alcohols, and more specifically, may be one or more selected from the group consisting of sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0051] In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, more preferably sorbitol or concentrated glycerin.

[0052] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total mass of the oral composition, thereby providing an oral composition with excellent moisturizing power in the oral cavity. The content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total mass of the oral composition, thereby making it possible to obtain an oral composition that is easy to rinse with gargle.

[0053] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0054] The flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium, since it has a strong sweetness and can adjust the taste even with a small amount.

[0055] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0056] The flavoring agent may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0057] Examples of coloring agents include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and coumarind colorant; legal colorants such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; and one or more selected from the group consisting of riboflavin and titanium dioxide.

[0058] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffers.

[0059] The solvent may be water, or a lower alcohol such as ethanol, propanol, etc. The solvent may be a liquid base.

[0060] The content of water in the oral composition can be, for example, the remainder after excluding components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, of the entire oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or the oral composition contains ethanol but the ethanol content is 5% by mass or less, which can suppress strong irritation to the oral cavity.

[0061] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0062] Other bases include, for example, sodium bicarbonate.

[0063] Detergents include, for example, sodium polyphosphate.

[0064] The adsorbent may be, for example, β-cyclodextrin.

[0065] Furthermore, in addition to the above components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0066] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. The oral composition is preferably a dentifrice composition, more preferably a toothpaste composition, which can further improve the ease of handling of the oral composition. From the same viewpoint, the oral composition is preferably in the form of a paste or gel.

[0067] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. Examples of toothbrushes that can be used with the oral composition include known toothbrushes. The toothbrush used in conjunction with the oral composition may be a conventional commercially available toothbrush.

[0068] (Manufacturing method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other ingredients as appropriate. Here, in order to obtain an oral composition in which (PF3)*(TF5) and TF10 are each within a specific range, it is important to appropriately select, for example, the components contained in the oral composition and their blending ratios, as well as to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the formulation. Abrasive silica and inorganic binders are preferably used in combination, and abrasive silica and thickening silica are more preferably used in combination. It is also preferable to further incorporate an organic binder into the oral composition. It is also preferable to further incorporate a humectant into the oral composition. It is also preferable to carry out the manufacturing process of the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add the thickening silica, abrasive, and other components as appropriate during or after mixing the humectant, organic binder, and water, and then stir and mix until uniform. It is also preferable to premix a portion of the humectant and the organic binder, add the mixture when the mixture is uniform, and stir until uniform. It is even more preferable to carry out these steps under vacuum.

[0069] (Toothpaste) In this embodiment, the dentifrice is the oral composition filled in a tube container, and preferably a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between the ease of squeezing it out of a tube container and the cushioning effect during tooth brushing, and by filling this into a tube container to make a dentifrice, it is possible to achieve excellent squeezability from the tube container. Furthermore, the squeezed dentifrice provides a desirable cushioning effect in the oral cavity.

[0070] Oral compositions such as toothpaste compositions are preferably used by squeezing them out of a tube container, and known tube containers can be used, for example. The material of the tube container can be one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc., and metal materials such as aluminum, etc. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum-laminated tube container may be used in which the innermost layer of the container is made of polyethylene and further includes an aluminum layer.

[0071] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more, which can more stably reduce the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and even more preferably 9 mm or less, which can efficiently prevent dripping. The length of the tube container excluding the discharge port may be about 50 to 160 mm, and the outer circumferential length in the width direction of the tube container may be about 20 to 120 mm.

[0072] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted. [Example]

[0073] The present embodiment will be specifically described below with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0074] (Examples 1 to 15, Comparative Examples 1 to 3) In this example, oral compositions, which are toothpaste compositions, were prepared and evaluated. The formulations, measurements, and evaluation results for each example are shown in Tables 1 to 3. The formulations of each component in these tables are in mass %, and the particle size of silica is the average particle size. Details of the components listed in Tables 1 to 3 are also shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Concentrated glycerin for cosmetics: Concentrated glycerin, manufactured by Sakamoto Pharmaceutical Industry Co., Ltd. Sodium alginate SHG: Sodium alginate, manufactured by Kohara Co., Ltd. NIKKOL SLS: Sodium lauryl sulfate, manufactured by Nikko Chemicals Caustic soda (48%): sodium hydroxide aqueous solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0075] (Preparation of oral composition) Sorbitol or glycerin and purified water were weighed into a beaker, and the organic binder was gradually added while stirring at 2500 rpm at 80°C using an emulsifying and dispersing device (Labo-Lution, Primix) and a stirring unit (Homodisper 2.5, Primix). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring with a rubber spatula each time until the mixture was uniform.

[0076] (Rheometer push test) PF3 was measured at 25°C using the method 1 described above. Device name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Push-in distance: 3mm Filling container: 30mL plastic jar (diameter 43mm) The maximum stress during indentation was measured three times, and the average value was calculated.

[0077] (Rheometer pull test) Measurements of TF5 and TF10 were carried out at 25°C using Method 2 described above. Instrument name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd., detection limit: 0.1 gf) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20mm) Measurement speed: 60mm / min Pull-up distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) The stress at each pulling distance was measured three times and the average value was calculated. Although the measured values ​​were negative, the absolute value (positive value) was used to compare the magnitude of the force.

[0078] (Evaluation method) (Easy to squeeze out) The ease of squeezing each toothpaste composition from a tube container was evaluated according to the following criteria, with A to C being considered acceptable. The tube container used was a laminated tube made of low-density polyethylene (LDPE) with an opening diameter of 19 mm and a size of 40Φ x 130H (40Φ One-Touch Tube-124.6, manufactured by Takemoto Container Co., Ltd.). The cap used was a one-touch cap made of polypropylene with an opening diameter of 6 mm and a size of 39Φ x 24H (T-40Φ One-Touch CAP II, manufactured by Takemoto Container Co., Ltd.). This was placed on a horizontal surface at room temperature (25°C), and one evaluator slowly pressed the center of the tube container with the pads of their index and middle fingers to dispense the composition, and the ease of squeezing was evaluated. A: Moderate pressure and easy to squeeze B: A little loose, but no problems with use C: Loose and prone to dripping from the mouth, but usable D: Hard and difficult to squeeze out

[0079] (Cushioning) The toothpaste composition of each example was filled into a tube container used to evaluate ease of squeezing. A 1.5 cm length of each toothpaste composition was placed on a toothbrush (manufactured by Lion Corporation) with an 18 mm head and saturated polyester resin bristles, and three evaluators applied the composition to the entire teeth. During application, the softness of the toothbrush's contact with the gums and tooth surface was evaluated by consensus according to the following criteria, with A to C being considered acceptable. A: It feels soft to the touch. B: Feels slightly soft C: I feel a slight change in the feel D: I don't feel any softness at all.

[0080] [Table 1]

[0081] [Table 2]

[0082] [Table 3]

Claims

1. An oral composition comprising an abrasive and a binder, When the maximum pushing stress in a 3 mm indentation test measured by the following method 1 is defined as PF3, and the pulling stress in a 5 mm tensile test and a 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively, (PF3) * (TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, An oral composition having a TF10 of 4.0 gf or more and 50 gf or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60mm / min Push-in distance: 3 mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the instrument, the container is pushed to the pushing distance at the measuring speed, and the maximum stress during pushing is measured. The average value of three measurements is defined as PF3. (Method 2) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60mm / min Pulling distance: 5mm or 10mm Filling container: 30mL plastic jar (diameter 43mm) Procedure: The oral composition is filled into the container until it is full, and after setting it in the instrument, the container is pulled up at the measurement speed. The absolute value of the stress at each pulling distance is measured. The average value of three measurements at each pulling distance is designated as TF5 or TF10.

2. The oral composition of claim 1 , wherein the binder comprises a thickening silica.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. 4. The oral composition according to claim 3, wherein the organic binder is one or more selected from the group consisting of carboxymethyl cellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).

5. The oral composition of claim 1 or 2, wherein the abrasive comprises abrasive silica.

6. The oral composition of claim 1 or 2, further comprising a humectant.

7. The oral composition according to claim 1 or 2, which is a dentifrice composition.

8. 3. The oral composition according to claim 1, which is a toothpaste composition.

9. A dentifrice comprising the oral composition according to claim 8 packed in a tube container.

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