Purification column

Abstract

To provide a liquid straightening plate for a purification column capable of preventing the drift or stagnation of a liquid in the column at the time of the passage of the liquid.SOLUTION: The column container includes a cylindrical column container whose both ends are open ends, a plate-like part, and a hollow cylindrical projection part arranged at the center of the upper surface of the plate-like part. The plate-shaped portion is provided with a first hole communicating with a hollow space of the protruding portion, the protruding portion includes a liquid rectifying plate having one or more notches at a tip end portion in a longitudinal direction or having one or more second holes on a side surface, the liquid rectifying plate being accommodated in the column container, a pipe having a plurality of third holes on a side surface, and a purification material, the liquid rectifying plate and the pipe are integrally molded, A part of the third hole and the notch or the second hole communicate with each other, and a purification material is filled around the pipe.SELECTED DRAWING: Figure 1B

Description

[Technical Field]

[0001] The present invention relates to a purification column. [Background technology]

[0002] To date, columns packed with various purification materials have been developed for the purpose of efficiently removing harmful substances from water and body fluids.

[0003] For example, Patent Document 1 discloses a body fluid purification module consisting of a fabric having body fluid purification capabilities and a housing portion filled with the fabric, in which the fabric is wound in a roll around a pipe having a porous portion, and disk-shaped objects are provided at both ends of the pipe.

[0004] It is disclosed that in the module, the disk-shaped object has excellent ability to retain the shape of the fabric, and can prevent the fabric from being disturbed or moved due to the flow of bodily fluids. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 9-239022 Summary of the Invention [Problem to be solved by the invention]

[0006] However, the disk-shaped object described in Patent Document 1 is designed to improve the retention of the fabric within the column and prevent the fabric from becoming distorted or moving, in order to reduce the uneven flow of body fluids that occurs in the gap between the column wall and the fibrous or rod-shaped adsorbent material.However, it does not anticipate the risk of body fluids stagnating or uneven flow in the purification material around the end of the pipe when body fluids are passed through it, and there is a concern that this may reduce purification performance or increase column pressure, shortening the time available for purification.

[0007] In view of the problems of the prior art, the present invention aims to provide a liquid straightening plate for a purification column that can prevent uneven flow or stagnation of liquid inside the column when the liquid is passed through. [Means for solving the problem]

[0008] As a result of extensive research to solve the above problems, we discovered that by improving the structure of the liquid straightening plate and providing a new flow path that can communicate with the holes on the side of the pipe, it is possible to suppress liquid stagnation and uneven flow.

[0009] That is, the present invention includes the following (1) to (5). (1) A purification column comprising: a cylindrical column container having open ends at both ends; a plate-like portion; and a hollow cylindrical protruding portion located in the center of the upper surface of the plate-like portion, the plate-like portion having a first hole formed therein that communicates with the hollow space in the protruding portion; the protruding portion having one or more notches at its longitudinal tip or one or more second holes on its side surface; a liquid rectifying plate housed in the column container; pipes having a plurality of third holes on their side surfaces; and purification material; the liquid rectifying plate and the pipes being integrally molded; some of the third holes communicating with the notches or the second holes; and the purification material packed around the pipes. (2) The purification column according to (1), wherein the outer periphery of the notch or the second hole coincides with at least a portion of the outer periphery of the third hole communicating with the notch or the second hole. (3) The purification column according to (1) or (2), wherein a plurality of the notches or a plurality of the second holes are arranged rotationally symmetrically on the central axis in the longitudinal direction. (4) The purification column according to any one of (1) to (3), wherein, in a front view, the cutouts are arranged in a U-shape recessed toward the base end in the longitudinal direction. (5) The purification column according to any one of (1) to (4), which is used for blood purification. [Effects of the Invention]

[0010] A purification column using the liquid rectifying plate of the present invention can prevent retention or uneven flow of liquid within the column when the liquid is passed through, thereby improving purification performance and extending purification time. [Brief explanation of the drawings]

[0011] [Figure 1A] FIG. 1 is a plan view showing an example of a liquid rectifying plate (with two notches) of the present invention. [Figure 1B] FIG. 1 is a front view showing an example of a liquid rectifying plate (with two notches) of the present invention. [Figure 2A] FIG. 1 is a plan view showing an example of a liquid rectifying plate (with four cutouts) of the present invention. [Figure 2B] FIG. 1 is a front view showing an example of a liquid rectifying plate (with four notches) of the present invention. [Figure 3A] FIG. 10 is a plan view showing an example of a liquid rectifying plate (with two second holes) of the present invention. [Figure 3B] FIG. 10 is a front view showing an example of a liquid rectifying plate (with two second holes) of the present invention. [Figure 4A] FIG. 2 is a plan view showing another embodiment of the liquid rectifying plate shown in FIGS. 1A and 1B. [Figure 4B] FIG. 2 is a front view showing another embodiment of the liquid rectifying plate shown in FIGS. 1A and 1B. [Figure 5] FIG. 10 is a schematic diagram showing a pipe that fits into a liquid rectifying plate. [Figure 6] 6 is a schematic diagram showing the state in which the liquid rectifying plate shown in FIG. 4A and FIG. 4B is fitted to the pipe shown in FIG. 5. [Figure 7A] FIG. 2 is a plan view showing a sealing plate that constitutes a purification column. [Figure 7B] FIG. 2 is a front view showing a sealing plate that constitutes a purification column. [Figure 8] FIG. 5 is a schematic diagram showing a vertical cross section of a purification column incorporating the liquid rectifying plate shown in FIGS. 4A and 4B when liquid is allowed to flow in from the sealing plate side. [Figure 9]FIG. 5 is a schematic diagram showing a vertical cross section of a purification column incorporating the liquid rectifying plate shown in FIGS. 4A and 4B when liquid is allowed to flow in from the liquid rectifying plate side. [Figure 10A] FIG. 10 is a plan view showing an example of a conventional liquid rectifying plate without a notch. [Figure 10B] FIG. 10 is a front view showing an example of a conventional liquid rectifying plate without a notch. [Figure 11] 10C is a schematic diagram showing a vertical cross section of a purification column incorporating the liquid rectifying plate shown in FIGS. 10A and 10B when liquid is allowed to flow in from the sealing plate side. FIG. [Figure 12] FIG. 10C is a schematic diagram showing a vertical cross section of a purification column incorporating the liquid rectifying plate shown in FIGS. 10A and 10B when liquid is introduced from the liquid rectifying plate side. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, embodiments of the present invention will be described with reference to the drawings. However, the present invention is not limited to these. Furthermore, the dimensional proportions in the drawings are exaggerated for the sake of explanation and may differ from the actual proportions.

[0013] First, an example of an embodiment of a liquid rectifying plate of the present invention will be described with reference to FIGS. 1A, 1B, 2A, 2B, 3A, 3B, 4A and 4B.

[0014] As shown in Figures 1A and 1B, the liquid straightening plate 1 of this embodiment comprises a plate-shaped portion 2 that ensures the retention of purification material when preparing a purification column, and a hollow cylindrical protrusion 3 located in the center of the upper surface of the plate-shaped portion 2, and the plate-shaped portion 2 has a first hole 4 formed therein that communicates with the hollow space in the protrusion 3, and the protrusion 3 has a notch 5 at its longitudinal tip that can be used as a flow path.

[0015] Each component is described in detail below. The shape of the plate-shaped portion 2 is not particularly limited, and may be circular, polygonal (e.g., rectangular), or the like. However, in the case of a circular shape, in a configuration in which a purification material such as a fabric or an adsorbent is wrapped around a pipe, the purification material can be densely packed up to the circular outer periphery of the plate-shaped portion 2, thereby expanding the effective area of ​​the purification material. Therefore, a circular shape is preferred for the plate-shaped portion 2. Furthermore, although not shown in FIGS. 1A and 1B , it is preferable to form irregularities on the surface of the plate-shaped portion 2 to prevent displacement of the purification material and improve retention. The shape of the irregularities is not particularly specified, but when the plate-shaped portion 2 is circular, it is preferable to form one or more irregularities in a concentric circle. The protrusion 3 has a hollow cylindrical shape to allow liquid to pass through it. It is connected to the plate-shaped portion 2 and communicates concentrically with the first hole 4 formed in the plate-shaped portion 2, thereby enabling liquid to pass through the liquid rectifying plate 1. The protrusion 3 has one or more flow paths such as notches 5 (in another embodiment, second holes 7 (see FIG. 3B )) formed at the other end (also referred to as the longitudinal tip) of the protrusion 3 that is not connected to the plate-like portion 2, so that the liquid can flow in or out from the side of the protrusion 3. The shape of the notches 5, as viewed from the front, is not particularly limited and may be U-shaped, V-shaped, semicircular, rectangular, or the like. However, considering the decrease in the flow rate of the liquid at the corners, the generation of vortices, retention, and fitting strength, a U-shape (e.g., a U-shape recessed toward the longitudinal base end) or a semicircular shape (e.g., a semicircular shape recessed toward the longitudinal base end) is preferred. When the notch 5 is U-shaped or semicircular, the curvature 6 can be appropriately selected taking into account the viscosity of the liquid, the opening width of the notch 5, the inner diameter of the hollow portion of the protrusion 3, and the like. Furthermore, when the notches 5 of the liquid straightening plate 1 are connected to the third holes 10 formed in the pipe 9 shown in Fig. 5, it is preferable that the curvature 6 is equal to or less than the radius of the third holes 10. Furthermore, when two or more notches 5 are formed, it is preferable that the notches 5 are arranged rotationally symmetrically about the central axis A in the longitudinal direction of the protrusion 3, since this can prevent bias in the liquid flow. In Fig. 1B, the dashed dotted line indicates that the two notches 5 are arranged rotationally symmetrically.

[0016] The material of the liquid rectifying plate 1 is preferably a resin from the viewpoint of disposability, and suitable examples include polypropylene, polycarbonate, polystyrene, polyvinyl chloride, and acrylonitrile butadiene styrene (ABS).

[0017] The liquid rectifying plate 1 may be made by separately manufacturing the plate-shaped portion 2 and the protruding portion 3 and assembling them, but taking into consideration the risk of misalignment during assembly, liquid leakage due to gaps caused by improper assembly, and the cost required for assembly, it is preferable to mold the liquid rectifying plate 1 as a single unit from resin.

[0018] 2A and 2B are diagrams showing an embodiment of a liquid rectifying plate in which four notches 5 are arranged in the protruding portion 3. Apart from the arrangement of four notches 5, the configuration is the same as that shown in FIGS. 1A and 1B, and two sets of notches 5 are arranged rotationally symmetrically about the central axis A of the protruding portion 3 in the longitudinal direction.

[0019] 3A and 3B show another embodiment of a liquid rectifying plate. This plate has the same configuration as those shown in FIGS. 1A and 1B, except that two second holes 7 communicating with the hollow portion of the protrusion 3 are provided instead of the notches 5 shown in FIGS. 1A and 1B. The shape of the second holes 7 is preferably the same as that of the third holes 10 of the pipe 9 to which they are connected, and a circular shape is preferable considering moldability and processability. The size and position of the second holes 7 are determined as appropriate depending on the liquid viscosity, the properties of the purification material, and the configuration of the purification column. However, it is preferable to determine the size and position of the second holes 7 so that they can communicate with the third holes 10 formed in the pipe 9. When two or more second holes 7 are provided, it is preferable to arrange the second holes 7 rotationally symmetrically about the central axis A of the protrusion 3 to prevent uneven liquid flow. In FIG. 3B, the dashed line indicates that the two second holes 7 are arranged rotationally symmetrically.

[0020] 4A and 4B show another embodiment of the liquid rectifying plate, which has the same configuration as that shown in FIGS. 1A and 1B except that ribs 8 are formed on the outer peripheral surface of the protrusion 3. Preferably, one or more ribs 8 are provided, and more preferably, two or more ribs 8 are provided, in order to improve the fitting strength with the pipe 9 shown in FIG. 5. The ribs 8 may be fabricated as separate components and then assembled to the protrusion 3. However, considering the risk of missing ribs or assembly defects, it is preferable that the ribs 8 be integrally molded with the protrusion 3 and the plate-shaped portion 2. The shape of the ribs 8 may be determined taking into account the fitting dimensions so as to obtain friction resistance with the grooves 11 formed in the pipe 9 when inserted into the grooves. While there are no particular limitations on the shape, easy-to-form shapes such as triangles, rectangles, and trapezoids are preferred. For example, the ribs 8 may be arranged on the outer peripheral surface of the protrusion 3, extending along the longitudinal direction of the protrusion 3. When two or more ribs 8 are provided, it is preferable to arrange the ribs 8 rotationally symmetrically about the central axis A of the protruding portion 3, but this is not a limitation.

[0021] Next, an example of a pipe to be fitted with the liquid rectifying plate 1 will be described using the front and bottom views shown in FIG. 5 . The interior of the pipe 9 is a hollow cylinder through which liquid can pass. A plurality of third holes 10 are formed on the side of the pipe 9 so as to communicate with the interior of the pipe 9. The third holes 10 guide the liquid into the inside of the pipe 9 or discharge the liquid to the outside of the pipe 9. The shape of the third holes 10 can be selected appropriately, such as a circle (e.g., a perfect circle or an ellipse) or a polygon (e.g., a rectangle). However, a rectangle or an ellipse is suitable from the viewpoint of excellent workability when forming holes at the tip. Furthermore, the shapes of all the third holes 10 may be the same, or the shape of the third holes 10 communicating with the liquid rectifying plate 1 may be different from the shape of the other third holes 10. The opening area of ​​each of the third holes 10 may be the same, or only the area of ​​the third holes 10 communicating with the liquid rectifying plate 1 may be different. However, from the viewpoint of suppressing liquid stagnation, it is preferable to make the area of ​​the third holes 10 communicating with the liquid rectifying plate 1 larger than the area of ​​the other third holes 10. When constructing a column, the pipe 9 can be fitted with the liquid rectifying plate 1 at one end and the sealing plate 12 at the other end. One end of the pipe 9 may be formed with a groove 11 that fits with the rib 8 of the liquid rectifying plate 1. The shape and dimensions of the groove 11 may be determined taking into consideration the fit with the rib 8.

[0022] FIG. 6 is a schematic diagram showing the liquid rectifying plate 1 (with ribs) shown in FIGS. 4A and 4B fitted to the pipe 9 (with grooves) shown in FIG. 5 . By arranging the notches 5 of the liquid rectifying plate 1 to communicate with the third holes 10 located at the end-most side of the pipe 9 (the most downstream or most upstream side when the liquid is flowing), improved fluidity can be expected. Furthermore, from the viewpoint of suppressing uneven flow of the liquid, it is preferable that the outer periphery of the notch 5 or the second hole 7 coincides with at least a portion of the outer periphery of the third hole 10 communicating with the notch 5 or the second hole 7. That is, it is preferable that the outer periphery of the third hole 10 shown in FIG. 6 coincides with the outer periphery of the part of the curvature 6 of the notch 5 that is in contact, and that the third hole 10 is enclosed within the notch 5. When the second holes 7 are formed in the liquid rectifying plate 1, it is preferable that the outer periphery of the second holes 7 coincides with at least a portion of the outer periphery of the third holes 10. The upstream side means the side into which the liquid flows, and the downstream side means the side from which the liquid flows out.

[0023] From the viewpoint of excellent operability when filling the purification material, it is preferable to manufacture the liquid straightening plate 1 and the pipe 9 separately and then assemble them, but they can also be molded as a single unit.

[0024] The ribs 8 and grooves 11 not only increase the fitting strength between the liquid straightening plate 1 and the pipe 9, but also serve to position the third hole 10 and the cutout 5 or the second hole 7 when connecting them and aligning their outer peripheries.

[0025] 7A and 7B are a plan view and a front view showing a sealing plate 12 that constitutes a purification column, and the sealing plate 12 is composed of a sealing plate portion 13 and a solid protruding portion 14. The sealing plate 12 is used for the purposes of dispersing the liquid flowing into the purification column 15 and sealing the liquid that has flowed into the pipe 9. The sealing plate 12 may be formed by assembling the sealing plate portion 13 and the solid protruding portion 14 after they have been manufactured separately. However, if a gap occurs between the sealing plate portion 13 and the solid protruding portion 14 during assembly, the sealing effect will not be achieved, and therefore it is preferable to mold the sealing plate 12 as a single unit.

[0026] Next, a purification column incorporating the liquid rectifying plate of the present invention and a purification column incorporating a conventional liquid rectifying plate without a notch will be described with reference to FIGS. 8, 9, 11 and 12. FIG.

[0027] FIG. 8 is a schematic diagram showing a vertical cross section of an example of a purification column 15 when liquid flows in from the sealing plate 12 side. A purification material 19 is wound around a pipe 9, and the liquid rectifying plate 1 and sealing plate 12 are joined together. The column is then inserted into a column housing 21 equipped with a filter 18 and an inlet header 16. The filter 18 is then attached and sealed with an outlet header 17. The pipe 9 and the liquid rectifying plate 1 are joined together, and the notch 5 and the third hole 10 (the reference number for the third hole 10 in the cross-sectional cut portion in FIG. 8 is omitted) are connected. The flow of liquid in the purification column 15 is as follows: liquid flows in from the inlet header 16, passes through the filter 18, and then flows into the gap between the sealing plate 12 and the column housing 21. The components to be removed from the inflowing liquid are adsorbed and removed by the purification material 19, and then the liquid flows into the inside of the pipe 9 through the third hole 10, passes through the inside of the liquid rectification plate 1 and the filter 18, and the purified liquid flows out from the outflow header 17. At this time, the presence of the notch 5 makes it possible to provide the third hole 10 also at the end of the pipe 9, which improves the fluidity of the liquid and makes it possible to suppress stagnation and uneven flow of the liquid that occurs downstream of the purification material 19.

[0028] FIG. 9 is a schematic diagram showing a longitudinal cross section of an example of a purification column 15 when liquid is introduced from the liquid rectifying plate 1 side. The flow of liquid within the purification column 15 is as follows: liquid enters through the inlet header 16, passes through the filter 18, flows into the liquid rectifying plate 1 and the inside of the pipe 9, and then flows into the purification material 19 through the third hole 10. The inlet liquid flows into the gap between the purification material 19 and the column housing 21, passes through the filter 18, and the purified liquid flows out of the outlet header 17. The notch 5 allows the third hole 10 to be provided at the end of the pipe 9, thereby increasing the flow rate upstream of the purification material 19 and suppressing stagnation and drift that occur upstream of the purification material 19. The direction of liquid flow within the purification column can be selected appropriately depending on the characteristics of the product.

[0029] 10A and 10B are a plan view and a front view showing an example of a notch-less liquid straightening plate 20, which is a conventional liquid straightening plate without a notch, and has the same configuration as FIGS. 1A and 1B except that the notch 5 is not present.

[0030] 11 is a longitudinal cross-sectional view of a purification column incorporating the notch-less liquid rectifying plate 20 shown in FIGS. 10A and 10B when liquid flows in from the sealing plate 12 side, and has the same configuration as FIG. 8 except that the liquid rectifying plate 1 is replaced with the notch-less liquid rectifying plate 20. When the notch-less liquid rectifying plate 20 is used, it is not possible to provide the third hole 10 at the end of the pipe, which raises concerns about stagnation and drift of the purification material 19 downstream.

[0031] 10A and 10B, the liquid flows in from the rectifying plate 1 side, and the configuration is the same as that shown in FIG. 9 except that the liquid rectifying plate 1 is replaced with the notch-less liquid rectifying plate 20. When the notch-less liquid rectifying plate 20 is used, it is not possible to provide the third hole 10 at the end of the pipe, which raises concerns about stagnation and drift of the purification material 19 on the upstream side.

[0032] A liquid rectifying plate is one of the components built into a purification column. A purification column simply comprises a cylindrical column container (also called a column housing or module) with both ends open, a liquid rectifying plate housed in the column container, a pipe having a plurality of third holes on the side, and a purification material, and can be appropriately combined with a filter, a sealing plate, a header, a connector, etc. The liquid rectifying plate can be suitably used, for example, as a component of a radial flow column in which liquid can flow radially from the pipe.

[0033] The purification column can be suitably used for liquid treatment applications, such as water treatment applications and medical applications. Examples of water treatment applications and medical applications include use as a column for water purifiers and blood purification.

[0034] Blood purification columns can be used to purify biological components in blood, such as whole blood, serum, and plasma. For example, they can be suitably used as extracorporeal circulation columns that purify and treat blood components extracted from patients, purification columns for producing blood products that separate and purify blood extracted from healthy individuals, and purification columns used during blood transfusions and analysis of blood components.

[0035] The purification material packed in the purification column is preferably one capable of purifying liquids such as water, blood, amniotic fluid, ascites, and pleural effusion. When purifying water, materials capable of purifying chlorine, trihalomethanes, bacteria, heavy metals, and the like can be used. When purifying biological components such as blood, plasma, and serum, materials capable of purifying bacteria, toxins produced by bacteria, viruses, activated leukocytes and platelets, inflammatory cytokines, anti-inflammatory cytokines, chemokines, adhesion molecules, leukotrienes, and the like, which are known to be deeply involved in inflammatory pathologies, can be used. When purifying amniotic fluid from perinatal pregnant women or ascites and pleural effusions accumulated due to inflammation, materials capable of removing bacteria, toxins produced by bacteria, viruses, leukocytes and platelets, inflammatory cytokines, chemokines, adhesion molecules, leukotrienes, and the like can be used.

[0036] The form of the purification material is not particularly limited. For example, a plurality of layers of sheet-shaped purification material made of fibrous materials such as knitted fabric, woven fabric, felt, or nonwoven fabric can be stacked and wrapped around the pipe of a radial flow column. Purification materials such as beads, chips, or hollow fibers can also be packed around the pipe. Different forms of purification materials can also be packed in the same column.

[0037] The material of the purifying material is not particularly limited as long as it is a material commonly used for purifying liquids, but water-insoluble polymeric compounds are preferably used. The water-insoluble polymeric compounds are not particularly limited in terms of chemical or physical structure, but examples include synthetic polymeric compounds such as poly(aromatic vinyl compounds), polyesters, polysulfones, polyethersulfones, polystyrenes, and polyvinyl alcohols, as well as natural polymers such as cellulose, collagen, chitin, chitosan, and dextran. These polymeric compounds may be used as homopolymers, copolymers, blends, or alloys. Among these, it is preferable to use one or more polymeric compounds selected from the group consisting of poly(aromatic vinyl compounds), polyethylene terephthalate, polybutylene terephthalate, polystyrene, polysulfones, and polyethersulfones, which are polymeric materials without hydroxyl groups. It is more preferable to use one or more polymeric compounds containing polystyrene, polyethylene, or polypropylene as the main component. These water-insoluble polymeric compounds are generally commercially available or can be produced by known methods.

[0038] Methods for quantifying the liquid retention improvement effect of the liquid straightening plate include, for example, fluid analysis tests (simulations) and fluid analysis tests (analysis using dyes).These test methods are described below.

[0039] 1. Fluid analysis test (simulation) Fluid analysis testing (simulation) is a method for evaluating liquid retention by simulating the flow rate of liquid at any point when liquid is introduced into a purification column. For example, a 3D model of the purification column is created using simulation software (SIEMENS, model: STAR-CCM+ 11.04), and water (density: 997.062 kg / m) is introduced from the inlet header of the purification column. 3 By simulating the flow rate when a liquid (0.89 mPa·s, viscosity) is passed through at a flow rate of 100 mL / min, it is possible to predict the degree of retention that occurs due to a decrease in flow rate.

[0040] 2. Fluid analysis test (analysis using dyes) Fluid analysis testing (analysis using dyes) is a method that can confirm drift by evaluating the degree of dyeing of the purification material when a liquid containing a substance that has an affinity with the purification material or a substance that adsorbs to the purification material (e.g., a dye such as methyl orange) is passed through a purification column.

[0041] When manufacturing a purification column, a liquid rectifying plate and a pipe are connected, so a certain level of fitting strength is required between the liquid rectifying plate and the pipe. One method for quantifying the fitting strength between the liquid rectifying plate and the pipe is a fitting strength test using a Tensilon tensile tester. The test method is described below.

[0042] 3. Fitting strength test The fitting strength test is a method for evaluating the fitting strength between a liquid rectifying plate and a pipe, using a Tensilon tensile testing machine (SHIMADZU, model: EZ-LX) to evaluate the stress (N) at the moment the fitting comes loose. The liquid rectifying plate and pipe are fitted together and set in the testing machine, and tensile stress is applied to the fitting. The stress (N) at the moment the fitting comes loose is measured three times and the average value is calculated. The test is performed at room temperature. The standard for fitting strength is 30N. The basis for setting this standard is that the maximum operating pressure during operation of a purification column is generally set at 13N (500mmHg), so for added safety, this is set at more than double that, at 30N. [Example]

[0043] The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.

[0044] Example 1 1. Example of preparation of purification column 1 A liquid rectifying plate (hereinafter referred to as Liquid Rectifying Plate 1) was fabricated, which had a hollow cylindrical protrusion (outer diameter: 8 mm, inner diameter: 5.8 mm, cylindrical height: 9 mm) located at the center of the top of a disk-shaped portion (diameter: 46 mm, thickness: 3 mm), and two notches (short direction: 5.3 mm, long direction: 5 mm, curvature: 0.5 rad / m) provided at the longitudinal tip of the protrusion so as to be rotationally symmetrical. In addition, a pipe (hereinafter referred to as Pipe 1: length 124 mm, outer diameter: 12 mm, inner diameter: 8 mm, with 40 circular holes (diameter 4.5 mm) on the side and two circular holes (diameter 5.2 mm) that could communicate with Liquid Rectifying Plate 1) was fabricated to fit with Liquid Rectifying Plate 1. Next, the purification material was wrapped around the pipe 1, and the sealing plate 12 shown in Figures 7A and 7B was fitted to the inlet end of the pipe 1, and the liquid rectifying plate 1 was fitted to the outlet end of the pipe 1 so that the two cutout portions of the liquid rectifying plate 1 communicated with the holes of the pipe 1. Next, the integrated pipe 1, purification material, and two plates were packed into a column container to produce a cylindrical purification column 1 (hereinafter, the purification column of Example 1).

[0045] Example 2 2. Example of preparation of purification column 2 A liquid rectifying plate (hereinafter referred to as Liquid Rectifying Plate 2) was fabricated. The plate had a disk-shaped portion (diameter: 46 mm, thickness: 3 mm) with a hollow cylindrical protrusion (outer diameter: 8 mm, inner diameter: 5.8 mm, cylindrical height: 9 mm) located at the center of the top. Two notches (5.3 mm in the transverse direction, 5 mm in the longitudinal direction, curvature: 2.0 rad / m, U-shaped recessed toward the base end in the longitudinal direction) were provided at the tip of the protrusion in a rotationally symmetrical manner. A pipe (hereinafter referred to as Pipe 2: length: 124 mm, outer diameter: 12 mm, inner diameter: 8 mm, 40 circular holes (4.5 mm diameter) and two rectangular holes (3.9 mm in the longitudinal direction, 5.7 mm in the transverse direction) that could communicate with the liquid rectifying plate were also fabricated. Next, the purification material was wrapped around the pipe 2, and the sealing plate 12 shown in Figures 7A and 7B was fitted to the inlet end of the pipe 2, and the liquid rectifying plate 2 was fitted to the outlet end of the pipe 2 so that the two cutout portions of the liquid rectifying plate 2 communicated with the holes of the pipe 2. Next, the integrated pipe 2, the purification material, and the two plates were packed into a column container to produce a cylindrical purification column 2 (hereinafter, the purification column of Example 2).

[0046] Example 3 3. Example of preparation of purification column 3 A liquid straightening plate (hereinafter referred to as liquid straightening plate 3) was fabricated, which had a hollow cylindrical protrusion (outer diameter: 8 mm, inner diameter: 5.8 mm, cylindrical height: 9 mm) located at the center of the top of a disc-shaped portion (diameter: 46 mm, thickness: 3 mm), two notches (short-side: 5.3 mm, long-side: 5 mm, U-shaped recessed toward the base end in the longitudinal direction with a curvature of 2.0 rad / m) at the longitudinal tip of the protrusion, and two ribs (longitudinal length: 8 mm, short-side length: 0.8 mm, thickness: 0.8 mm) attached to the outer peripheral surface of the protrusion in a rotationally symmetrical manner. In addition, a pipe to be fitted with the liquid rectifying plate 3 (hereinafter, pipe 3: length 124 mm, outer diameter: 12 mm, inner diameter: 8 mm, with 40 circular holes (diameter 4.5 mm) on the side and two rectangular holes (longitudinal length 3.9 mm, lateral length: 5.7 mm) that can communicate with the liquid rectifying plate 3, and two grooves on the inside of the pipe 3 (longitudinal length: 8 mm, lateral length: 1 mm, thickness: 1 mm)) was prepared. Next, a purification material was wrapped around the pipe 3, and the sealing plate 12 shown in Figures 7A and 7B was fitted to the inlet end of the pipe 3, and the two cutout portions of the liquid rectifying plate 3 were connected to the holes of the pipe at the outlet end of the pipe 3, and the ribs of the liquid rectifying plate 3 were fitted to the grooves of the pipe 3, respectively. Next, the integrated pipe 3, the purification material, and the two plates were packed into a column container to prepare a cylindrical purification column 3 (hereinafter, the purification column of Example 3).

[0047] (Comparative Example 1) 4. Example of preparation of purification column 4 A notch-less liquid rectifying plate (hereinafter referred to as liquid rectifying plate 4) as shown in FIGS. 9A and 9B was fabricated. The liquid rectifying plate had a hollow cylindrical protrusion (outer diameter: 8 mm, inner diameter: 5.8 mm, cylindrical height: 9 mm) located at the center of the upper part of a disk-shaped portion (diameter: 46 mm, thickness: 3 mm). A pipe (hereinafter referred to as pipe 4: length: 124 mm, outer diameter: 12 mm, inner diameter: 8 mm, 40 circular holes (diameter: 4.5 mm) on the side) to be fitted with the liquid rectifying plate was also fabricated. Next, a purification material was wrapped around pipe 4, and the sealing plate shown in FIGS. 7A and 7B was fitted to the inlet end of pipe 4, and liquid rectifying plate 4 was fitted to the outlet end of pipe 4. Next, the integrated pipe 4, purification material, and two plates were packed into a column container to fabricate a cylindrical purification column 4 (hereinafter referred to as the purification column of Comparative Example 1).

[0048] Example 4 5. Fluid analysis method (simulation) for purification columns In order to evaluate the retention improvement effect of the liquid rectifying plate, a 3D model of each of the purification columns of Examples 1 to 3 and Comparative Example 1 was created using simulation software (SIEMENS, model: STAR-CCM+ 11.04). Water (density: 997.062 kg / m) was introduced from the inlet header of the purification column. 3 A liquid (viscosity: 0.89 mPa s) was passed through the purification columns of Examples 1 to 3 at a flow rate of 100 mL / min. To confirm the flow rate near the new flow path created by connecting the notch in the liquid rectifying plate with the third hole in the side of the pipe in the purification columns of Comparative Example 1, the flow rate was measured at a position 8 mm from the outer circumferential surface of the pipe where the most liquid accumulated, in the direction of the pipe periphery, and 3 mm from the surface of the plate-like portion in contact with the pipe, in the direction of the inlet header of the pipe axis. Simulations were performed with the liquid flow in the direction shown in Figure 8 for the purification columns of Examples 1 to 3, and in the direction shown in Figure 11 for the purification column of Comparative Example 1. The results are shown in Table 1.

[0049] Example 5 6. Fluid analysis of a dye-based purification column To evaluate the effect of the liquid rectifying plate in improving drift, a 1.5 g / L aqueous solution of methyl orange was pumped through the purification column at a flow rate of 100 mL / min for 4.5 minutes, after which the column was disassembled and the degree of staining of the purification material was visually observed. If any areas of the adsorption carrier were not stained with methyl orange (white areas), the result was judged as "spotted," whereas if the entire surface was stained, the result was "no spotted." In other words, if drift occurred and the liquid flow was uneven, the result was "spotted," and if the liquid flow was uniform, the result was "no spotted." The liquid flowed in the purification columns of Examples 1 to 3 in the direction shown in Figure 8, and in the purification column of Comparative Example 1 in the direction shown in Figure 11. The results are shown in Table 1.

[0050] Example 6 7. Fitting strength test To evaluate the fitting strength between the liquid rectifying plate and the pipe, a Tensilon tensile testing machine (SHIMADZU, model: EZ-LX) was used to fit the liquid rectifying plate and the pipe together, and the fitting was set in the testing machine. Tensile stress was applied to the fitting, and the stress (N) at the moment the fitting came loose was measured three times and the average value was calculated. The test was performed at room temperature. The results are shown in Table 1.

[0051] [Table 1]

[0052] The results in Table 1 show that providing a notch in the protruding portion of the liquid rectifying plate, which serves as a new flow path that can communicate with the third hole provided on the side of the pipe, improves liquid retention and uneven flow. Furthermore, by making the notch in the protruding portion of the liquid rectifying plate U-shaped, recessed toward the base end in the longitudinal direction, it is possible to improve the fitting strength while maintaining the effect of improving retention and uneven flow. Furthermore, by making the notch in the protruding portion U-shaped, recessed toward the base end in the longitudinal direction, and by providing ribs to the protruding portion of the liquid rectifying plate, it is possible to further improve the fitting strength while maintaining the effect of improving retention and uneven flow. [Industrial Applicability]

[0053] Use of the liquid rectifying plate of the present invention can prevent liquid from stagnating or drifting within the column when the liquid is passed through, thereby improving purification efficiency and extending the purification time. Therefore, a purification column equipped with the liquid rectifying plate can be widely used in liquid purification applications such as water treatment and medical use. [Explanation of symbols]

[0054] 1 Liquid rectification plate 2 Plate-shaped part 3 Protrusion 4 First hole 5 Cutout 6 Curvature 7 Second hole 8. Ribs 9 Pipes 10 Third Hole 11 Groove 12 Sealing plate 13 Sealing plate 14 Solid protrusion 15 Purification column 16 Inflow Header 17 Leaked Header 18 filters 19 Purification materials 20. Liquid rectification plate without cutout 21 Column housing A center axis

Claims

1. a cylindrical column container having both open ends; a plate-shaped portion and a hollow cylindrical protrusion disposed at the center of an upper surface of the plate-shaped portion; a first hole communicating with the hollow space of the protrusion is formed in the plate-like portion; a liquid straightening plate accommodated in the column container, the protrusion having one or more notches at a tip end in a longitudinal direction or one or more second holes on a side surface; a pipe having a plurality of third holes in a side thereof and a purification material; Equipped with a purification column in which the liquid rectifying plate and the pipe are integrally molded, a portion of the third hole communicates with the notch or the second hole, and a purification material is packed around the pipe.

2. The purification column according to claim 1 , wherein an outer periphery of the notch or the second hole coincides with at least a portion of an outer periphery of the third hole communicating with the notch or the second hole.

3. The purification column according to claim 1 or 2, wherein a plurality of the notches or a plurality of the second holes are arranged rotationally symmetrically about the central axis in the longitudinal direction.

4. The purification column according to any one of claims 1 to 3, wherein the cutouts are arranged in a U-shape recessed toward the base end in the longitudinal direction when viewed from the front.

5. The purification column according to any one of claims 1 to 4, which is used for blood purification.

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