Method and kit for treating skin

Abstract

To provide a method for treating skin using an anhydrous composition capable of reducing greasiness or oiliness and also capable of providing good penetration of skin care active ingredients into the skin.SOLUTION: The present invention relates to a method for treating skin, comprising the steps of (1) applying on the skin a first composition comprising (a) at least one peeling agent and (2) applying on the skin a second composition comprising (b) at least one skin care active ingredient and (c) water; Wherein the first composition is anhydrous and the amount of (c) water in the second composition is 40% by weight or more, preferably 50% by weight or more, and more preferably 60% by weight or more, relative to the total weight of the second composition. The process according to the invention uses a first composition that is anhydrous, but can provide a reduction in greasiness or oiliness. The method according to the invention can also result in good penetration of skincare active ingredients into the skin.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a method and kit for treating the skin with two different compositions. [Background technology]

[0002] In the field of cosmetics, there exists anhydrous cosmetics that do not contain water or contain only a small amount of water.Anhydrous cosmetics typically contain at least one oil as the main component.Anhydrous cosmetics tend to have greasiness or oiliness after application, which is uncomfortable.

[0003] On the other hand, users are increasingly demanding cosmetic compositions that can provide skin care benefits. To achieve skin care benefits, skin care active ingredients are generally included in cosmetic compositions, and the skin care active ingredients are expected to penetrate into the skin. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] EP-A-0487404 [Patent Document 2] EP-A-0425066 [Patent Document 3] Japanese Patent Publication No. 05-213736 [Patent Document 4] EP0667145 [Patent Document 5] EP1430883 [Patent Document 6] WO02 / 051828 [Non-patent literature]

[0005] [Non-Patent Document 1] Meylan and Howard, Atom / Fragment contribution method for estimating octanol-water partition coefficients, J. Pharm. Sci., 84: 83-92, 1995. Summary of the Invention [Problem to be solved by the invention]

[0006] There remains a need to reduce the greasiness or oiliness of thickened anhydrous compositions.

[0007] There is also a separate need for methods that can provide good penetration of skin care active ingredients into the skin.

[0008] It is an object of the present invention to provide a method for treating skin using an anhydrous composition that can provide reduced greasiness or oiliness and also provide good penetration of skin care actives into the skin. [Means for solving the problem]

[0009] The above object of the present invention is a method for treating the skin, comprising: (1) On the skin, (a) at least one peeling agent applying a first composition comprising: (2) On the skin, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: Including, the first composition is anhydrous; This can be achieved by a method in which the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

[0010] (a) The peeling agent may be selected from mechanical peeling agents, preferably water-soluble particles, more preferably water-soluble polysaccharide particles such as sucrose particles.

[0011] On the other hand, (a) the peeling agent may be selected from chemical peeling agents, preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, and more preferably polyhydroxy acids in the form of lactones such as gluconolactone.

[0012] The amount of (a) the peeling agent in the first composition may be 0.01% by mass to 15% by mass, preferably 0.05% by mass to 10% by mass, and more preferably 0.1% by mass to 5% by mass, relative to the total mass of the first composition.

[0013] The first composition may further comprise (d) at least one oil other than a fatty alcohol.

[0014] The first composition may further comprise (e) at least one organic lipophilic gelling agent selected from urethane polymers.

[0015] The first composition may further comprise (f) at least one fatty alcohol.

[0016] (b) The skin care active may be selected from skin lightening agents, skin anti-aging agents, skin moisturizers, and mixtures thereof.

[0017] (b) The skin care active may be selected from the group consisting of C-glycoside derivatives, hyaluronic acid and its salts, such as sodium hyaluronate, and mixtures thereof.

[0018] (b) The skin care active ingredient is C-beta-D-xylopyranoside-n-propan-2-one, C-alpha-D-xylopyranoside-n-propan-2-one, C-beta-D-xylopyranoside-2-hydroxypropane, C-alpha-D-xylopyranoside-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(C-alpha-D-glucopyranosyl)-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-aminopropane, 1-(C-alpha-D-glucopyranosyl)-2-aminopropane, 3'-(acetamido-C-beta-D-glucopyranosyl) and 1-(acetamido-C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(acetamido-C-beta-D-glucopyranosyl)-2-aminopropane, and salts thereof, solvates thereof, for example hydrates, and optical isomers thereof, preferably C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, more preferably C-beta-D-xylopyranoside-2-hydroxypropane.

[0019] The amount of (b) skin care active ingredient in the second composition may be 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, relative to the total mass of the second composition.

[0020] The method according to the present invention may further comprise the step of massaging or rubbing the skin between steps (1) and (2).

[0021] The present invention also provides a kit for treating skin, comprising: (1) (a) at least one oil other than a fatty alcohol; a first compartment containing a first composition comprising: (2) (b) at least one skin care active ingredient, and (c) water a second compartment containing a second composition comprising Equipped with the first composition is anhydrous; The present invention also relates to a kit in which the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

[0022] The (a) peeling agent in the first composition in the kit according to the present invention may be selected from mechanical peeling agents, preferably from water-soluble particles, more preferably from water-soluble polysaccharide particles, such as sucrose particles.

[0023] On the other hand, the peeling agent (a) in the first composition in the kit according to the present invention may be selected from chemical peeling agents, preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, and more preferably polyhydroxy acids in the form of lactones such as gluconolactone. DETAILED DESCRIPTION OF THE INVENTION

[0024] After extensive investigation, the inventors have discovered that it is possible to provide a method for treating skin using anhydrous compositions that can provide reduced greasiness or oiliness and also provide better penetration of skin care actives into the skin.

[0025] To achieve a method that can provide reduced greasiness or oiliness and also provide better penetration of skin care actives into the skin, the method according to the present invention combines two steps: using a first composition that is anhydrous and includes at least one peeling agent, and using a second composition, which is another composition that includes at least one skin care active and a significant amount of water.

[0026] Therefore, one aspect of the present invention is a method for treating skin, comprising: (1) On keratinous materials, (a) at least one peeling agent applying a first composition comprising: (2) On keratinous materials, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: Including, the first composition is anhydrous; The method is such that the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

[0027] The method according to the present invention combines the use of a first composition that is anhydrous with the use of a second composition that contains a significant amount of (c) water, which can provide a cooling sensation. Thus, the method according to the present invention uses a first composition that is anhydrous, but can provide reduced greasiness or oiliness.

[0028] Because the first composition (a) contains a peeling agent, the first composition can exfoliate the superficial layers of the skin, such as the stratum corneum, which (b) allows the skin care active ingredient to more easily penetrate into the skin. Therefore, the method according to the present invention can provide good penetration of the skin care active ingredient into the skin.

[0029] If the (a) peeling agent is selected from water-soluble particles, the method according to the present invention can also provide a clean skin finish because the second composition can dissolve the (a) peeling agent.

[0030] The present invention will be described in detail below.

[0031] [method] The method for treating skin according to the present invention comprises: (1) On keratinous materials, (a) at least one peeling agent applying a first composition comprising: (2) On keratinous materials, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: Including, the first composition is anhydrous; The amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, based on the total mass of the second composition.

[0032] The first and second compositions used in the method according to the present invention are described in detail below.

[0033] {First composition} The first composition used in the method according to the invention comprises: (a) An anhydrous composition comprising at least one peeling agent.

[0034] The term "anhydrous" composition, as used herein, means a composition that does not contain water or that contains less than 3% by weight, preferably less than 1% by weight, more preferably less than 0.1% by weight of water relative to the total weight of the composition.

[0035] (peeling agent) The first composition used in the method according to the present invention comprises (a) at least one peeling agent. Two or more (a) peeling agents may be used in combination. Thus, a single type of peeling agent or a combination of different types of peeling agents may be used.

[0036] Peeling agents, as used herein, refer to substances capable of removing the superficial layers of the skin, for example the stratum corneum or keratinized layer of the skin.

[0037] (a) The peeling agent may be selected from mechanical peeling agents, chemical peeling agents, and mixtures thereof.

[0038] Mechanical peeling agents can remove superficial layers such as the stratum corneum from the skin by any mechanical action such as scrubbing.

[0039] Chemical peeling agents can remove superficial layers, such as the stratum corneum, from the skin by any chemical action, such as dissolving the superficial layers.

[0040] The mechanical peeling agent may be selected from water-soluble particles.

[0041] Water-soluble particles: The term "water soluble" as used herein refers to a water soluble polymer at room temperature (25°C) and atmospheric pressure (10 5 By "solubility in water" is meant a substance that has a solubility in water at 1000 kJ / L (at 2500 kJ / s), preferably at least 10 g / L, more preferably at least 100 g / L (at 2500 kJ / s).

[0042] Preferably, the water-soluble particles are insoluble in oil, ie, have a solubility in oil of less than 1 g / L, preferably less than 0.1 g / L.

[0043] The water-soluble particles may be of any shape, regardless of crystalline form (eg, lamellar, cubic, hexagonal, orthorhombic, etc.), and may be platelet-shaped, spherical, oval, or polygonal.

[0044] In a preferred embodiment of the present invention, the water-soluble particles can function as water-soluble scrubbing particles. The water-soluble particles as scrubbing particles can physically destroy the skin, particularly the stratum corneum. In this embodiment, the water-soluble particles can be formed in the form of particles with hard, sharp edges and rough surfaces. The sharp-edged particles can be formed in the form of polygonal pyramids.

[0045] In certain embodiments of the present invention, the water-soluble particles may have an aspect ratio of at least 1.1, preferably at least 1.2, more preferably at least 1.5, even more preferably at least 2, and especially at least 2.5. In other embodiments of the present invention, the water-soluble particles may have an aspect ratio of 2 or less, preferably 1.5 or less, and more preferably 1.2 or less. The aspect ratio can be measured by techniques common in the art, for example, by image analysis using an electron microscope.

[0046] In another specific embodiment of the present invention, the water-soluble particles may have an average circularity, as determined by image analysis, of 0.95 or less, preferably 0.9 or less, more preferably 0.85 or less, and even more preferably 0.8 or less. In another embodiment of the present invention, the water-soluble particles may have an average circularity, as determined by image analysis, of 0.7 or more, preferably 0.8 or more, more preferably 0.85 or more, and even more preferably 0.9 or more.

[0047] The "average circularity" can be determined by image analysis. In particular, the "average circularity" can be the arithmetic mean of the circularities obtained by image analysis of scanning electron microscope (SEM) images of 2000 or more particles observed at 1000x magnification by secondary electron detection using a scanning electron microscope (SEM).

[0048] The "circularity" of each particle is a value determined by the following formula: C=4πS / L 2 [Where C represents circularity, S represents the area (projected area) of the particle in the image, and L represents the perimeter (outer perimeter) of the particle in the image.] As the average circularity approaches 1, the shape of each particle becomes more spherical.

[0049] The water-soluble particles may have an average primary particle size of 10 μm or more, preferably 30 μm or more, more preferably 50 μm or more, even more preferably 100 μm or more, and particularly 200 μm or more. The average primary particle size of the water-soluble particles may be 1 mm or less, preferably 800 μm or less, more preferably 600 μm or less, and even more preferably 500 μm or less.

[0050] The term "average primary particle size" as used herein refers to the volume-average size mean diameter given by the statistical particle size distribution for half of the population, D 50 For example, the volume average particle size can be measured with a laser diffraction particle size distribution analyzer, such as a Mastersizer 2000 from Malvern Corp.

[0051] The material of the water-soluble particles is not particularly limited as long as it dissolves upon contact with water, but preferably the water-soluble particles are composed of ingredients that are cosmetically beneficial to the skin.

[0052] For example, the water-soluble particles can be composed of polysaccharides, monosaccharides, amino acids, sugar alcohols, ascorbic acid, and mixtures thereof. Polysaccharides can include disaccharides such as sucrose, lactose, maltose, and trisaccharides such as raffinose, as well as mucopolysaccharides such as chondroitin sulfate and heparin. Monosaccharides can include pentoses, hexoses, and heptoses such as glucose, dextrose, galactose, mannose, and glucuronic acid. Sugar alcohols can include sorbitol and glucamine. Ascorbic acid can include vitamin C (ascorbic acid) and its derivatives, such as ascorbyl glucoside.

[0053] Preferably, the water-soluble particles comprise polysaccharide particles, more preferably sucrose.

[0054] Therefore, in one embodiment, (a) the peeling agent is preferably selected from mechanical peeling agents, more preferably selected from water-soluble particles, and even more preferably selected from water-soluble polysaccharide particles, such as sucrose particles.

[0055] Chemical peeling agents may be selected from polyhydroxy acids.

[0056] Polyhydroxy acids: The term "polyhydroxy acid" as used herein refers to an organic compound having at least one carboxy group and multiple hydroxy groups. The number of carboxy groups in the polyhydroxy acid is not limited, but one or two carboxy groups are preferred, and one carboxy group is more preferred. The number of hydroxy groups in the polyhydroxy acid is also not limited, but 2 to 10 are preferred, and 2 to 6 are more preferred. The number of carbon atoms in the polyhydroxy acid is not limited, but 3 to 11 are preferred, and 3 to 8 are more preferred.

[0057] The organic compound may be aliphatic or aromatic. In other words, the polyhydroxy acid may be selected from aliphatic polyhydroxy acids or aromatic polyhydroxy acids. The aliphatic polyhydroxy acid is preferably selected from sugar acids.

[0058] Examples of polyhydroxy acids include dihydroxypropanoic acids such as glyceric acid; trihydroxybutyric acids such as erythronic acid and threonic acid; tetrahydroxypentanoic acids such as ribonic acid, arabinonic acid, xylonic acid, and lyxonic acid; pentahydroxyhexanoic acids such as allonic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, and talonic acid; hexahydroxyheptanoic acids such as glucoheptanoic acid and galactoheptonic acid; tartaric acid; lactobionic acid, maltobionic acid, and mixtures thereof.

[0059] The polyhydroxy acid is preferably in the form of a lactone. The lactone ring of the polyhydroxy acid in the form of a lactone may be saturated. Examples of polyhydroxy acids in the form of lactones include gluconolactone, ribonolactone, and mixtures thereof.

[0060] More preferably, the (a) peeling agent is gluconolactone.

[0061] The polyhydroxy acid may be in the form of a salt.

[0062] The type of salt is not limited. Examples of salts include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; zinc salts; iron salts; ammonium salts; amine salts such as monoethanolamine salts, diethanolamine salts, and triethanolamine salts; and mixtures thereof. Sodium salts are preferred. When two or more salts are used, they may be the same or different.

[0063] Chemical peeling agents may be selected from monohydroxy acids.

[0064] Monohydroxy acids: The term "monohydroxy acid" as used herein refers to an organic compound having at least one carboxy group and one hydroxy group. The number of carboxy groups in a monohydroxy acid is not limited, but one or two carboxy groups are preferred, and one carboxy group is more preferred. The number of carbon atoms in a monohydroxy acid is not limited, but 3 to 11 are preferred, and 3 to 8 are more preferred.

[0065] The monohydroxy acids may be selected from alpha-monohydroxy acids, beta-monohydroxy acids, and mixtures thereof.

[0066] The term "alpha-monohydroxy acid" as used herein means a carboxylic acid having at least one carboxy group and one hydroxy group separated by one carbon atom. Thus, in other words, an alpha-monohydroxy acid is a carboxylic acid having one hydroxy group on adjacent (alpha) carbon atoms.

[0067] The alpha-monohydroxy acid may be selected, for example, from glycolic acid, lactic acid, malic acid, citric acid, mandelic acid, and mixtures thereof, preferably from glycolic acid, citric acid, and mixtures thereof, more preferably from glycolic acid.

[0068] The term "beta-monohydroxy acid" as used herein means a carboxylic acid having at least one carboxy group and one hydroxy group separated by two carbon atoms.

[0069] The beta-monohydroxy acid may be salicylic acid.

[0070] The monohydroxy acid may be in the form of a salt.

[0071] The type of salt is not limited. Examples of salts include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; zinc salts; iron salts; ammonium salts; amine salts such as monoethanolamine salts, diethanolamine salts, and triethanolamine salts; and mixtures thereof. Sodium salts are preferred. When two or more salts are used, they may be the same or different.

[0072] Preferably, the chemical peeling agent is selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, more preferably gluconolactone, tartaric acid, mandelic acid, and mixtures thereof.

[0073] Therefore, in one embodiment, (a) the peeling agent is preferably selected from chemical peeling agents, more preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, and even more preferably polyhydroxy acids in the form of lactones such as gluconolactone.

[0074] The amount of the (a) peeling agent in the first composition may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, relative to the total mass of the first composition.

[0075] On the other hand, the amount of the (a) peeling agent in the first composition may be 20% by mass or less, preferably 15% by mass or less, and more preferably 10% by mass or less, relative to the total mass of the first composition.

[0076] Therefore, the amount of the peeling agent (a) in the first composition may be 0.01% by mass to 20% by mass, preferably 0.05% by mass to 15% by mass, and more preferably 0.1% by mass to 10% by mass, relative to the total mass of the first composition.

[0077] (oil) The first composition used in the method according to the present invention may contain at least one oil (d). Two or more oils (d) may be used in combination. Thus, a single type of oil may be used, or a combination of different types of oils may be used.

[0078] As used herein, the term "oil" refers to oil at atmospheric pressure (10 5 (d) Oils may be volatile or non-volatile.

[0079] (d) oils, as used herein, are not fatty alcohols, and therefore (d) oils are different from (f) fatty alcohols.

[0080] (d) The oil may be a non-polar oil such as a hydrocarbon oil or a silicone oil; a polar oil such as a vegetable oil or an animal oil and an ester oil or an ether oil; or a mixture thereof.

[0081] (d) It may be preferred that the oil is selected from the group consisting of vegetable-derived oils, synthetic oils such as ester oils, and mixtures thereof.

[0082] Examples of vegetable oils include linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, squalene, natural triglycerides, and mixtures thereof.

[0083] Examples of synthetic oils include alkane oils, such as hydrogenated polyolefins (eg, C6 to C20), ester oils (eg, ethylhexyl palmitate, isopropyl myristate), ether oils, and artificial triglycerides.

[0084] The ester oil is preferably a saturated or unsaturated, linear or branched C1-C 26 Aliphatic mono- or polyacids and saturated or unsaturated, linear or branched C1-C 26 It is a liquid ester of an aliphatic monoalcohol or polyalcohol, and the total number of carbon atoms in the ester is 10 or more.

[0085] Preferably, in esters of monoalcohols, at least one of the alcohol and acid from which the esters of the present invention are derived is branched.

[0086] Among the monoesters of monoacids and monoalcohols, mention may be made of ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristates such as isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate, isostearyl neopentanoate, and mixtures thereof.

[0087] C4~C 22 Dicarboxylic or tricarboxylic acids and C1-C 22 Esters with alcohols, and monocarboxylic, dicarboxylic or tricarboxylic acids with non-sugar C4-C 26 Esters with dihydroxy, trihydroxy, tetrahydroxy or pentahydroxy alcohols can also be used.

[0088] Mention may especially be made of diethyl sebacate, isopropyl lauroyl sarcosinate, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactate, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate, and mixtures thereof.

[0089] As ester oil, C6-C 30 of, preferably C 12 ~C 22 Sugar esters and diesters of fatty acids of the above can be used. It is recalled that the term "sugar" means an oxygen-carrying hydrocarbon-based compound containing at least four carbon atoms, with or without aldehyde or ketone functional groups, and containing some alcohol functional groups. These sugars can be monosaccharides, oligosaccharides, or polysaccharides.

[0090] Examples of suitable sugars that may be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose and lactose, as well as derivatives thereof, especially alkyl derivatives, such as methyl derivatives, e.g. methylglucose.

[0091] Sugar esters of fatty acids are in particular those which are formed by the abovementioned sugars with linear or branched, saturated or unsaturated C6-C 30 , preferably C 12 ~C 22 They can be selected from the group comprising esters or mixed esters with fatty acids. When they are unsaturated, these compounds can have 1 to 3 conjugated or non-conjugated carbon-carbon double bonds.

[0092] The esters according to this variant may also be chosen from monoesters, diesters, triesters, tetraesters and polyesters, and mixtures thereof.

[0093] These esters may be, for example, oleate, laurate, palmitate, myristate, behenate, coconut, stearate, linoleate, linolenate, caprate and arachidonic acid esters, or mixtures thereof, such as, inter alia, mixed esters of oleopalmitic acid, oleostearic acid and palmitostearic acid, and pentaerythrityl tetraethylhexanoate.

[0094] More particularly, monoesters and diesters are used, especially the mono- or dioleate, stearate, behenate, oleopalmitate, linoleate, linolenate and oleostearate of sucrose, glucose or methylglucose.

[0095] One example that may be mentioned is the product sold under the name Glucate® DO by the company Amerchol, which is a methylglucose dioleate.

[0096] Examples of preferred ester oils include diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl (caprylic / capric acid), methyl palmitate, ethyl palmitate, isopropyl palmitate, dicarbonate, Examples of suitable alkyl acrylates include purilyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0097] Examples of ether oils include dicaprylyl ether, dicapryl ether, dilauryl ether, diisostearyl ether, dioctyl ether, nonylphenyl ether, dodecyl dimethyl butyl ether, cetyl dimethyl butyl ether, cetyl isobutyl ether, and mixtures thereof.

[0098] Examples of artificial triglycerides include caprylic / caprylic triglyceride, glyceryl trimyristate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, capric / caprylic triglyceride, and capric / caprylic / linolenic triglyceride, and mixtures thereof.

[0099] The first composition may contain at least one silicone oil. Examples of silicone oils include linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, etc.; cyclic organopolysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.; and mixtures thereof.

[0100] Preferably, the oily phase of the present invention does not contain any silicone oil, in other words, the (d) oil of the present invention can be selected from non-silicone oils.

[0101] The first composition may comprise at least one hydrocarbon oil. The hydrocarbon oil may be chosen from: - linear or branched, optionally cyclic, C6-C 16 Lower alkanes, examples which may be mentioned include hexane, undecane, dodecane, tridecane, and isoparaffins, such as isohexadecane, isododecane, and isodecane; and - linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene and hydrogenated polyisobutenes, such as Parleam® and squalane.

[0102] Preferably, the hydrocarbon oil is derived from a renewable resource such as a plant.

[0103] Preferred examples of hydrocarbon oils include linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oil (e.g., liquid paraffin), paraffin, Vaseline or petrolatum, naphthalene, etc.; hydrogenated polyisobutene, isoeicosane, and decene / butene copolymers; and mixtures thereof.

[0104] (d) The oil is preferably selected from the group consisting of vegetable oils, ester oils, hydrocarbon oils, and mixtures thereof.

[0105] More preferably, the (d) oil is selected from the group consisting of vegetable oils such as jojoba oil, carbonate oils such as dicaprylyl carbonate, artificial triglyceride oils such as caprylic / capric triglyceride, hydrocarbon oils such as squalane, and mixtures thereof.

[0106] The amount of (d) oil in the first composition may be 50% by mass or more, preferably 60% by mass or more, and more preferably 70% by mass or more, based on the total mass of the first composition.

[0107] On the other hand, the amount of (d) oil in the first composition may be 95% by mass or less, preferably 90% by mass or less, and more preferably 85% by mass or less, based on the total mass of the first composition.

[0108] Therefore, the amount of (d) oil in the first composition may be in the range of 50% by mass to 95% by mass, preferably 60% by mass to 90% by mass, and more preferably 70% by mass to 85% by mass, relative to the total mass of the first composition.

[0109] (organic lipophilic gelling agent) The first composition used in the method according to the present invention may comprise at least one organic lipophilic gelling agent (e). Two or more organic lipophilic gelling agents (e) may be used in combination. Thus, a single type of organic lipophilic gelling agent may be used, or a combination of different types of organic lipophilic gelling agents may be used.

[0110] The term "lipophilic" as used herein refers to the degree of 5 "soluble in oil" means a substance that is soluble in oil at a concentration of at least 1% by weight (at 1000 kJ / Pa) relative to the total weight of the oil.

[0111] The term "gelling" as used herein means that component (e) is capable of thickening or increasing the viscosity of the first composition.

[0112] When the first composition includes (e) at least one organic lipophilic gelling agent, the first composition can be thickened and have suitable applicability (e.g., not falling off during application).

[0113] The first composition is preferably in the form of a gel, for example an oil gel.

[0114] The term "gel" as used herein includes thick liquids that may be Newtonian or non-Newtonian. Newtonian fluids refer to fluids whose viscosity does not change with changes in flow conditions. Gels also include shear-thinning gels.

[0115] In one preferred embodiment of the present invention, the first composition may be a gel having a non-Newtonian viscosity. In another preferred embodiment of the present invention, the first composition may be shear-thinning. A non-Newtonian shear-thinning material changes state from a gel to a liquid in the presence of applied shear stress and reverts to a gel in the absence of applied shear stress. A shear-thinning material, by definition, is one in which the viscosity of the material decreases nonlinearly as the applied shear stress is increased.

[0116] The first composition may be characterized by its rheological properties. The first composition may have a storage modulus (G') of 50 Pa to 10,000 Pa, preferably 100 Pa to 7,500 Pa, and more preferably 500 Pa to 5,000 Pa.

[0117] The storage modulus (G') can be measured using a rheometer with 40 mm parallel plates and the following conditions: Setting interval: 500μm Temperature: 25℃ Strain(%): 1% Frequency: 1Hz

[0118] The first composition may have more suitable applicability if its storage modulus (G') is 50 Pa or more and 10,000 Pa or less, because a storage modulus (G') of 50 Pa or more can prevent the first composition from being easily destroyed before application, and a storage modulus (G') of 10,000 Pa or less can prevent the first composition from becoming a hard solid that is difficult to apply.

[0119] When the first composition has the above storage modulus (G'), (a) the peeling agent can be well dispersed in the first composition, and therefore the first composition can effectively exfoliate the superficial layers of the skin, such as the stratum corneum.

[0120] (e) The organic lipophilic gelling agent is selected from urethane polymers. The term "urethane polymer" as used herein means a polymer containing at least one urethane bond (-NH-COO-). The urethane polymer preferably contains multiple urethane bonds, and more preferably contains multiple repeating units each containing at least one urethane bond, especially multiple urethane bonds.

[0121] The (e) organic lipophilic gelling agent may be crosslinked or non-crosslinked. The (e) organic lipophilic gelling agent is preferably crosslinked.

[0122] The (e) organic lipophilic gelling agent may be in the form of particles, preferably spherical particles. The (e) organic lipophilic gelling agent in the form of particles may have a number average particle size ranging, for example, from 1 μm to 20 μm. The term "number average size" refers to the size given by the random particle size distribution of half of the population, and D 50 (e) The organic lipophilic gelling agent may be in the form of a powder.

[0123] The (e) organic lipophilic gelling agent may be a copolymer. The (e) organic lipophilic gelling agent may be a copolymer of an isocyanate and trimethylolhexyllactone, in particular, a hexamethylene diisocyanate (HDI) / trimethylolhexyllactone crosspolymer. Examples of copolymers include urethane polymer powders sold by Toshiki Pigment Co., Ltd. under the names Plastic Powder D-400®, Plastic Powder D-800®, or Plastic Powder CS-400®, or by Lubrizol under the name Oilkemia® 5S CC Polymer.

[0124] Most preferably, as (e) organic lipophilic gelling agent, the first composition may include a hexamethylene diisocyanate (HDI) / trimethylol hexyl lactone crosspolymer, such as that sold under the name Oilkemia® 5S CC Polymer by Lubrizol.

[0125] The amount of (e) organic lipophilic gelling agent in the first composition may be 0.01% by weight or more, preferably 0.05% by weight or more, and more preferably 0.1% by weight or more, relative to the total weight of the first composition.

[0126] On the other hand, the amount of (e) organic lipophilic gelling agent in the first composition may be 5% by mass or less, preferably 4% by mass or less, and more preferably 3% by mass or less, relative to the total mass of the first composition.

[0127] Therefore, the amount of (e) organic lipophilic gelling agent in the first composition may be 0.01% by mass to 5% by mass, preferably 0.05% by mass to 4% by mass, and more preferably 0.1% by mass to 3% by mass, relative to the total mass of the first composition.

[0128] (e) The organic lipophilic gelling agent can thicken the first composition even when its amount is small, for example, 5% by mass or less, preferably 4% by mass or less, and more preferably 3% by mass or less, relative to the total mass of the first composition.

[0129] (fatty alcohol) The first composition used in the method according to the present invention may contain (f) at least one fatty alcohol. Two or more (f) fatty alcohols may be used in combination. Thus, a single type of fatty alcohol or a combination of different types of fatty alcohols may be used.

[0130] The term "aliphatic" as used herein refers to the inclusion of a relatively large number of carbon atoms. Thus, alcohols having 6 or more, preferably 8 or more, and more preferably 10 or more carbon atoms are included within the scope of aliphatic alcohols. The aliphatic alcohols may be saturated or unsaturated. The aliphatic alcohols may be linear or branched. Two or more aliphatic alcohols may be used in combination.

[0131] (f) The aliphatic alcohol may have the structure R—OH, where R is selected from saturated and unsaturated, straight-chain and branched groups containing from 8 to 40 carbon atoms, e.g., from 8 to 30 carbon atoms. In at least one embodiment, R is selected from C 12 ~C 24 Alkyl groups and C 12 ~C 24 R is selected from the group consisting of alkenyl groups, which may or may not be substituted with at least one hydroxy group.

[0132] (f) The fatty alcohol may be selected from linear or branched fatty alcohols.

[0133] Non-limiting examples of linear fatty alcohols that may be mentioned include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, arachidonyl alcohol, erucyl alcohol, cetearyl alcohol, and mixtures thereof.

[0134] Examples of suitable straight chain fatty alcohols include, but are not limited to, cetyl alcohol, cetearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, and mixtures thereof.

[0135] (f) Fatty alcohol may also represent a mixture of fatty alcohols, which means that several species of fatty alcohols can coexist in the form of a mixture in a commercial product.

[0136] Thus, according to at least one embodiment, the (f) fatty alcohol used in the first composition is chosen from a mixture of cetyl alcohol and cetearyl alcohol (cetearyl alcohol).

[0137] Non-limiting examples of branched fatty alcohols that may be mentioned include hexyldodecanol, octyldodecanol, and mixtures thereof.

[0138] (f) Aliphatic alcohols are used at room temperature (25°C) and atmospheric pressure (10 5 It is preferred that the compound is in the form of a liquid at or below 100 Pa.

[0139] (f) The fatty alcohol is preferably selected from branched fatty alcohols, more preferably selected from the group consisting of hexyldodecanol, octyldodecanol, and mixtures thereof.

[0140] The amount of (f) the aliphatic alcohol in the first composition may be 0.1% by mass or more, preferably 0.5% by mass or more, and more preferably 1% by mass or more, relative to the total mass of the first composition.

[0141] On the other hand, the amount of (f) aliphatic alcohol in the first composition may be 40% by mass or less, preferably 30% by mass or less, and more preferably 20% by mass or less, relative to the total mass of the first composition.

[0142] Therefore, the amount of (f) aliphatic alcohol in the first composition may be 0.1% by mass to 40% by mass, preferably 0.5% by mass to 30% by mass, and more preferably 1% by mass to 20% by mass, relative to the total mass of the first composition.

[0143] (Optional Ingredients) In addition to the above-mentioned components, the first composition may contain optional components typically used in cosmetics, specifically, lipophilic thickeners other than component (e), waxes, antioxidants, preservatives, etc., within ranges that do not impair the effects of the present invention.

[0144] The first composition may contain the above-mentioned optional components in an amount of 0.01% to 30% by mass, preferably 0.05% to 20% by mass, and more preferably 0.1% to 10% by mass, relative to the total mass of the first composition.

[0145] (preparation) The first composition can be prepared by mixing the essential components described above and, if necessary, the optional components described above.

[0146] The method and means for mixing the above essential components and optional components are not limited. Any conventional method and means can be used to mix the above essential components and optional components to prepare the first composition.

[0147] (form) The anhydrous first composition may be clear.

[0148] Clarity can be measured by measuring turbidity (for example, turbidity can be measured using a 2100Q (commercially available from Hach Company) with a round cell (25 mm diameter and 60 mm height) and a tungsten filament lamp capable of emitting visible light (between 400 and 800 nm, preferably 400 to 500 nm). Measurements can be performed on the undiluted composition. A blank can be determined using distilled water.

[0149] The first composition may have a turbidity of 200 NTU or less, preferably 150 NTU or less, more preferably 100 NTU or less, more preferably 50 NTU or less, more preferably 30 NTU or less, and even more preferably 10 NTU or less.

[0150] The first composition can take a variety of forms, such as a lotion, serum, suspension, dispersion, etc.

[0151] {Second Composition} The second composition used in the method according to the invention comprises: (b) at least one skin care active ingredient, and (c) water Including, The amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, based on the total mass of the second composition.

[0152] The second composition may be an aqueous composition because it contains a substantial amount of (c) water.

[0153] (skin care active ingredient) The second composition used in the method according to the present invention comprises (b) at least one skin care active. Two or more skin care actives may be used in combination. Thus, a single type of skin care active or a combination of different types of skin care actives may be used.

[0154] (b) It is preferred that the skin care active ingredient has a log P value in the range of -4.5 to 4.5, preferably -4.0 to 4.0, more preferably -3.5 to 3.5.

[0155] The log P value is the base 10 logarithm of the apparent octanol / water partition coefficient. Log P values ​​are known and are determined by standard tests that determine the concentration of the compound under consideration in octanol and water. Log P can be calculated by the method described in Meylan and Howard's article, "Atom / Fragment contribution method for estimating octanol-water partition coefficients," J. Pharm. Sci., Vol. 84, pp. 83-92, 1995. This value may also be calculated using a number of commercially available software packages that determine log P as a function of the molecule's structure. An example is Epiwin software from the U.S. Environmental Protection Agency.

[0156] This value can be calculated using, inter alia, ACD (Advanced Chemistry Development) Solaris software V4.67, and can also be obtained from Exploring QSAR: hydrophobic, electronic and steric constants (ACS professional reference book, 1995). There is also an internet site that provides approximate values ​​(address: http: / / esc.syrres.com / interkow / kowdemo.htm).

[0157] (b) The skin care actives may be in the form of salts. Salts of (b) the skin care actives include conventional, non-toxic salts of the compounds, for example, formed from acids or bases.

[0158] (b) The skin care active is preferably a skin care cosmetic active, more preferably a skin lightening agent or a skin anti-aging agent, e.g., an anti-wrinkle agent. The term "skin lightening agent," as used herein, refers to an agent that increases the whitening or lightening of the skin. Thus, "skin lightening agent" can be interchangeably referred to as "skin whitening agent."

[0159] (b) Skin care active ingredients include vitamin B3 and derivatives.

[0160] Vitamin B3, also known as vitamin PP, is a compound of the following formula:

[0161] [ka]

[0162] wherein R may be -CONH (niacinamide), -COOH (nicotinic acid or niacin), or CHOH (nicotinyl alcohol), -CO-NH-CH-COOH (nicotinuric acid), or -CO-NH-OH (nicotinylhydroxamic acid). Niacinamide is preferred.

[0163] Vitamin B3 derivatives that may be mentioned include, for example, nicotinic acid esters such as tocopherol nicotinate, amides derived from niacinamide by substitution of the hydrogen group of -CONH2, products from the reaction of carboxylic acids with amino acids, and esters of nicotinyl alcohol with carboxylic acids such as acetic acid, salicylic acid, glycolic acid or palmitic acid.

[0164] Mention may also be made of the following derivatives: 2-chloronicotinamide, 6-methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N,N-dimethylnicotinamide, N-(hydroxymethyl)nicotinamide, quinolinic acid imide, nicotinanilide, N-benzylnicotinamide, N-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, nialamide, 2-mercaptonicotinic acid, nicomol and niaprazine, methyl nicotinate and sodium nicotinate.

[0165] Other vitamin B3 derivatives that may also be mentioned are its inorganic salts, such as the chlorides, bromides, iodides or carbonates, and its organic salts, such as those obtained by reaction with carboxylic acids, such as acetates, salicylates, glycolates, lactates, malates, citrates, mandelates, tartrates, etc.

[0166] (b) Skin care active ingredients include ascorbic acid and its derivatives.

[0167] Ascorbic acid is generally in the L-form, as it is usually extracted from natural products.

[0168] Due to its chemical structure (α-keto lactone), which makes it highly sensitive to certain environmental parameters such as light, heat and aqueous media, it may be advantageous to use ascorbic acid in the form of a derivative or analogue selected, for example, from sugar esters of ascorbic acid, or metal salts, alkali metal salts, esters and sugars of phosphoryl ascorbic acid.

[0169] Sugar esters of ascorbic acid that can be used in the present invention are, inter alia, glycosyl, mannosyl, fructosyl, fucosyl, galactosyl, N-acetylglucosamine and N-acetylmuramic acid derivatives of ascorbic acid, and mixtures thereof, more particularly ascorbyl glucosides, such as ascorbyl-2-glucoside, 2-O-α-D-glucopyranosyl L-ascorbic acid, or 6-O-β-D-galactopyranosyl L-ascorbic acid. The latter compounds and methods for their preparation are described, inter alia, in documents EP-A-0487404, EP-A-0425066, and JP-A-05-213736.

[0170] As regards the metal salts of phosphoryl ascorbic acid, they may be selected from alkali metal ascorbyl phosphates, especially sodium ascorbyl phosphates, alkaline earth metal ascorbyl phosphates, and transition metal ascorbyl phosphates.

[0171] Ascorbic acid precursors can also be used, such as activator amides and activator sugar derivatives, which require proteases or peptidases and glycosidases, respectively, as enzymes to release ascorbic acid in situ. Such compounds are described in patent EP 0 667 145.

[0172] The active agent sugar derivative is especially selected from C3-C6 sugar derivatives, especially glucosyl, mannosyl, fructosyl, fucosyl, N-acetylglucosamine, galactosyl, and N-acetylgalactosamine derivatives, N-acetylmuramic acid derivatives, and sialic acid derivatives, and mixtures thereof.

[0173] The second ascorbic acid precursor may be selected from derivatives that are hydrolyzed by other enzymes, such as esterases, phosphatases, sulfatases, etc. According to the present invention, the second active agent precursor may be selected from, for example, phosphate esters, sulfate esters, palmitate esters, acetate esters, propionate esters, ferulate esters, and generally active agent alkyl or acyl esters, acyl or alkyl ethers. The acyl and alkyl groups in particular contain 1 to 30 carbon atoms. Mention may be made as a skin care active ingredient 3-O-ethyl ascorbic acid.

[0174] In particular, the second precursor may be an ester derived from reaction with a mineral acid, such as a sulfate or phosphate ester, which reacts with sulfatases or phosphatases on contact with the skin, or the second precursor may be an acyl or alkyl ester derived from reaction with an organic acid, such as palmitic acid, acetic acid, propionic acid, nicotinic acid, 1,2,3-propanetricarboxylic acid, or ferulic acid, which reacts with specific skin esterases.

[0175] Other derivatives are described, for example, in patent EP1430883.

[0176] Ascorbic acid analogues are more particularly salts thereof, especially alkali metal salts such as sodium ascorbate, esters thereof, especially acetate, propionate or palmitate esters, or sugars thereof, especially glycosyl ascorbic acids.

[0177] (b) Examples of skin care active ingredients include resorcinol derivatives.

[0178] The resorcinol derivative may preferably be a derivative substituted at the 4-position, such as a 4-alkylresorcinol, more preferably phenylethyl resorcinol, 4-n-butylresorcinol, and 4-(tetrahydro-2H-pyran-4-yl)benzene-1,3-diol, and particularly phenylethyl resorcinol for its skin lightening or whitening effect. Phenylethyl resorcinol is also called 4-(1-phenylethyl)-1,3-benzenediol and is represented by the following chemical formula: Phenylethyl resorcinol is available, for example, from Symrise Corp. (Product name: Symwhite 377®).

[0179] [ka]

[0180] Other examples of resorcinol derivatives that may be mentioned are: 2-methylresorcinol, 5-methylresorcinol, 4-methylresorcinol, 4-ethylresorcinol, 2,5-dimethylresorcinol, 4,5-dimethylresorcinol, 2,4-dimethyl-1,3-benzenediol, 3,5-dihydroxybenzylamine, 5-methoxyresorcinol, 3,5-dihydroxybenzyl alcohol, 2-methoxyresorcinol, 4-methoxyresorcinol, 3,5-dihydroxytoluene monohydrate, 4-chlororesorcinol, 2-chlororesorcinol, 2',4'-dihydroresorcinol, 2',4'-dihydro-2'-methyl ... Dihydroxyacetophenone, 3',5'-dihydroxyacetophenone, 2,6-dihydroxy-4-methylbenzaldehyde, 4-propylresorcinol, 2,4-dihydroxy-1,3,5-trimethylbenzene, 3,5-dihydroxybenzamide, 2,6-dihydroxybenzamide, 2,4-dihydroxybenzamide, 2,4-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,6-dihydroxy-4-methylbenzyl alcohol, 3,5-dihydroxyanisole hydrate, 4-amino Resorcinol hydrochloride, 2-aminoresorcinol hydrochloride, 5-aminobenzene-1,3-diol hydrochloride, 2',4'-dihydroxypropiophenone, 2',4'-dihydroxy-3'-methylacetophenone, (2,4-dihydroxyphenyl)acetone, (3,5-dihydroxyphenyl)acetone, 2,6-dihydroxy-4'-methylacetophenone, 4-n-butylresorcinol, 2,4-diethyl-1,3-benzenediol, 3,5-dihydroxy-4-methylbenzoic acid, 2,6-dihydroxy-4-methylbenzoic acid Fragrance, 2,4-dihydroxy-6-methylbenzoic acid, 3,5-dihydroxyphenylacetic acid, 2-ethyl-5-methoxybenzene-1,3-diol, 4-amino-3,5-dihydroxybenzoic acid, 3,5-dihydroxyacetophenone monohydrate, 3,5-dihydroxybenzylamine hydrochloride, 4,6-dichlororesorcinol, 2',4'-dihydroxy-3'-methylpropiophenone, 1-(3-ethyl-2,6-dihydroxyphenyl)ethan-1-one, 2',6'-dihydroxy-4'-methoxyacetophenone, 1-(2,6-dihydroxy-3-methoxyphenyl)ethan-1-one, 3(2,4-dihydroxyphenylpropionic acid, and 2,4-dihydroxy-3,6-dimethylbenzoic acid.

[0181] (b) Examples of active skin care ingredients include C-glycoside derivatives.

[0182] The C-glycoside derivatives that may be present in the second composition are compounds of the following general formula (II):

[0183] [ka]

[0184] [In the formula, R represents an unsubstituted linear C1-C4, especially C1-C2 alkyl group, in particular methyl; S represents a monosaccharide selected from D-glucose, D-xylose, N-acetyl-D-glucosamine, and L-fucose, in particular D-xylose; X represents a group selected from the group consisting of -CO-, -CH(OH)- and -CH(NH2)-, preferentially -CH(OH)-. and also cosmetically acceptable salts thereof, solvates thereof, such as hydrates, and optical isomers thereof.

[0185] Non-limiting examples of C-glycoside derivatives that are particularly more suitable for use in the present invention include, inter alia, the following derivatives: C-beta-D-xylopyranoside-n-propan-2-one, C-alpha-D-xylopyranoside-n-propan-2-one, C-beta-D-xylopyranoside-2-hydroxypropane, C-alpha-D-xylopyranoside-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(C-alpha-D-glucopyranosyl)-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-aminopropane, 1-(C-alpha-D-glucopyranosyl)-2-aminopropane, 3'-(acetamido-C-beta-D-glucopyranosyl)propan-2'-one, 3'-(acetamido-C-alpha-D-glucopyranosyl)propan-2'-one, 1-(acetamido-C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(acetamido-C-beta-D-glucopyranosyl)-2-aminopropane, and cosmetically acceptable salts thereof, solvates thereof, such as hydrates, and optical isomers thereof.

[0186] According to a particular embodiment, C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, and better still C-beta-D-xylopyranoside-2-hydroxypropane, may advantageously be used for the preparation of the second composition.

[0187] According to a particular embodiment, the C-glycoside derivative suitable for use in the present invention may advantageously be hydroxypropyltetrahydropyrantriol, also known as C-beta-D-xylopyranoside-2-hydroxypropane, sold in particular under the name Mexoryl SBB® by the company Chimex as a 30% by weight solution in a water / propylene glycol mixture (60 / 40). According to one embodiment, the C-glycoside derivative is in the form of a solution in which it is present in an amount of 30% by weight relative to the total weight of the solution, the remainder being a mixture of water and propylene glycol.

[0188] Salts of C-glycoside derivatives suitable for use in the present invention may include conventional physiologically acceptable salts of these compounds, such as salts formed with organic or mineral acids. Examples that may be mentioned include salts with mineral acids such as sulfuric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, phosphoric acid, and boric acid. Salts of organic acids, which may contain one or more carboxylic acid, sulfonic acid, or phosphoric acid groups, may also be mentioned. These may be linear, branched, or cyclic aliphatic acids, or aromatic acids. These acids may also contain one or more heteroatoms selected from O and N, for example, in the form of hydroxyl groups. Among these, propionic acid, acetic acid, terephthalic acid, citric acid, and tartaric acid may be mentioned.

[0189] Acceptable solvates of the compounds mentioned above include conventional solvates, for example those formed during the final steps of the preparation of said compounds due to the presence of a solvent. Examples that may be mentioned include solvates resulting from the presence of water or linear or branched alcohols, such as ethanol or isopropanol.

[0190] C-glycoside derivatives suitable for use in the present invention can be obtained inter alia by the synthesis methods described in document WO 02 / 051828, the contents of which are incorporated herein by reference.

[0191] In one embodiment, (b) the skin care active ingredient is C-beta-D-xylopyranoside-n-propan-2-one, C-alpha-D-xylopyranoside-n-propan-2-one, C-beta-D-xylopyranoside-2-hydroxypropane, C-alpha-D-xylopyranoside-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(C-alpha-D-glucopyranosyl)-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-aminopropane, 1-(C-alpha-D-glucopyranosyl)-2-aminopropane, 3'-(acetamido-C-beta-D-glucopyranosyl) Preferably, the hydroxybenzoate is selected from the group consisting of C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, and more preferably C-beta-D-xylopyranoside-2-hydroxypropane, C-beta-D-xylopyranoside-2-hydroxypropane, C-alpha ...

[0192] (b) The skin care active may be selected from hyaluronic acid and its salts.

[0193] Hyaluronic acid is the predominant glycosaminoglycan found in the skin. Therefore, fibroblasts predominantly synthesize collagen, non-collagenous matrix glycoproteins (fibronectin, laminin), proteoglycans, and elastin. Keratinocytes, for their part, predominantly synthesize sulfated glycosaminoglycans and hyaluronic acid. Hyaluronic acid is also called hyaluronan.

[0194] Hyaluronic acid exists in free state in epidermis and dermis, and it is responsible for the turgor of skin.This polysaccharide can actually hold a large volume of water, up to 1000 times its mass.In this sense, hyaluronic acid plays an important role in increasing the amount of water bound in tissue, and also in the mechanical properties and wrinkle formation of skin.

[0195] Hyaluronic acid can be represented by the following chemical formula:

[0196] [ka]

[0197] In the context of the present invention, the term "hyaluronic acid" specifically encompasses the basic unit of hyaluronic acid of the formula:

[0198] [ka]

[0199] It is the smallest part of hyaluronic acid, containing a disaccharide dimer, namely D-glucuronic acid and N-acetylglucosamine.

[0200] Salts may include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts, ammonium salts, and mixtures thereof.

[0201] The molecular weight of hyaluronic acid or its salt is not limited. The molecular weight of hyaluronic acid may be 5 kDa or more, preferably 20 kDa or more, more preferably 100 kDa or more. The molecular weight of hyaluronic acid or its salt may be 20 MDa or less, preferably 10 MDa or less, more preferably 2,000 kDa or less. Therefore, the molecular weight of hyaluronic acid may be 5 kDa to 20 MDa, preferably 20 kDa to 10 MDa, more preferably 100 kDa to 2,000 kDa.

[0202] Unless otherwise defined in the description, "molecular weight" may mean weight average molecular weight.

[0203] Hyaluronic acid and its salts can function as moisturizers or humectants for the skin.

[0204] (b) The skin care active ingredient is preferably selected from skin lightening agents, skin anti-aging agents, skin moisturizers, and mixtures thereof.

[0205] (b) The skin care active ingredient is preferably selected from the group consisting of C-glycoside derivatives, salicylic acid and its derivatives, polyhydroxy acids and their salts, hyaluronic acid and its salts, such as sodium hyaluronate, and mixtures thereof.

[0206] The amount of (b) the skin care active ingredient in the second composition may be 0.01% by weight or more, preferably 0.05% by weight or more, more preferably 0.1% by weight or more, based on the total weight of the second composition.

[0207] On the other hand, the amount of (b) skin care active ingredient in the second composition may be 15% by weight or less, preferably 10% by weight or less, and more preferably 5% by weight or less, relative to the total weight of the second composition.

[0208] Therefore, the amount of (b) skin care active ingredient in the second composition may be 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, relative to the total mass of the second composition.

[0209] (water) The second composition used in the method according to the invention comprises (c) water.

[0210] The amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, based on the total mass of the second composition.

[0211] On the other hand, the amount of (c) water in the second composition may be 99% by mass or less, preferably 97% by mass or less, and more preferably 95% by mass or less, based on the total mass of the second composition.

[0212] Therefore, the amount of (c) water in the second composition may be 40% by mass to 99% by mass, preferably 50% by mass to 97% by mass, and more preferably 60% by mass to 95% by mass, relative to the total mass of the second composition.

[0213] (Optional Ingredients) In addition to the above-mentioned components, the second composition may contain optional components typically used in cosmetics, specifically oils, surfactants, emulsifiers, hydrophilic thickeners, polyols, preservatives, etc., within ranges that do not impair the effects of the present invention.

[0214] The second composition may contain the above optional components in an amount of 0.01% to 50% by mass, preferably 0.05% to 40% by mass, and more preferably 0.1% to 30% by mass, relative to the total mass of the second composition.

[0215] When the second composition comprises at least one oil, the above description of the (d) oil of the first composition can also be applied to the oil in the second composition.

[0216] When the second composition comprises at least one oil, typically together with a surfactant or emulsifier, the second composition may be, for example, in the form of an O / W emulsion or O / W dispersion.

[0217] When the second composition comprises at least one oil, the amount of oil in the second composition may be 30% by weight or less, preferably 20% by weight or less, more preferably 10% by weight or less, relative to the total weight of the second composition.

[0218] When the second composition comprises at least one polyol such as glycerin, the amount of polyol in the second composition may be 50% by weight or less, preferably 40% by weight or less, more preferably 30% by weight or less, based on the total weight of the second composition.

[0219] (preparation) The second composition can be prepared by mixing the essential components described above and, if necessary, the optional components described above.

[0220] The method and means for mixing the above essential components and optional components are not limited. Any conventional method and means can be used to mix the above essential components and optional components to prepare the second composition.

[0221] (form) The second composition may be clear.

[0222] Clarity can be measured by measuring turbidity (for example, turbidity can be measured using a 2100Q (commercially available from Hach Company) with a round cell (25 mm diameter and 60 mm height) and a tungsten filament lamp capable of emitting visible light (between 400 and 800 nm, preferably 400 to 500 nm). Measurements can be performed on the undiluted composition. A blank can be determined using distilled water.

[0223] The second composition may have a turbidity of 200 NTU or less, preferably 150 NTU or less, more preferably 100 NTU or less, more preferably 50 NTU or less, more preferably 30 NTU or less, and even more preferably 10 NTU or less.

[0224] The second composition can take a variety of forms, such as a lotion, serum, suspension, dispersion, etc.

[0225] {process} The method according to the present invention comprises a first step (1) of applying a first composition onto the skin and a second step (2) of applying a second composition onto the skin, the second step (2) following the first step (1).

[0226] Skin as used herein includes facial skin, neck skin and scalp. The method according to the invention can also be used on mucous membranes such as the lips.

[0227] The method according to the invention is a non-therapeutic method, preferably a cosmetic method, more preferably a cosmetic method for skin care.

[0228] The method for applying the first or second composition to the skin is not particularly limited, and any method known in the art can be used. Generally, the first or second composition can be applied by hand.

[0229] The method according to the present invention may further comprise a step of massaging or rubbing the skin between the first step (1) and the second step (2). In other words, the skin to which the first composition has been applied may be massaged or rubbed. The massaging or rubbing may be performed by any means, for example, by fingers. The massaging or rubbing may be performed for at least 10 seconds. The massaging or rubbing may facilitate the disruption or exfoliation of the surface of the skin, particularly the stratum corneum, by the peeling agent (a) in the first composition. The massaging or rubbing may further enhance the penetration of the skin active ingredient (b) into the skin.

[0230] The method according to the present invention may further comprise the step of removing the first composition from the skin, which may be carried out, for example, by rinsing with water.

[0231] The massaging or rubbing step and / or the removing step may be performed before applying the second composition onto the skin.

[0232] After applying the second composition onto the skin, the method according to the present invention may further comprise the step of (b) leaving the second composition on the skin for a certain period of time, for example, several minutes, to ensure penetration of the skin care active ingredient into the skin.

[0233] After applying the second composition onto the skin, the method according to the present invention may or may not include the step of removing the second composition from the skin.

[0234] {Embodiment} According to one preferred embodiment, the method according to the invention comprises: (1) On the skin, (a) at least one peeling agent applying a first composition comprising: the first composition is anhydrous; applying a first composition, wherein the amount of the peeling agent (a) in the first composition is 0.01% by mass to 20% by mass relative to the total mass of the first composition; (2) On the skin, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: the amount of (b) the skin care active ingredient in the second composition is 0.01% by mass to 15% by mass, based on the total mass of the second composition; applying a second composition, wherein the amount of (c) water in the second composition is 40% by mass or more; Includes.

[0235] According to a more preferred embodiment, the method according to the invention comprises: (1) On the skin, (a') at least one peeling agent selected from mechanical peeling agents and chemical peeling agents; applying a first composition comprising: the first composition is anhydrous; applying a first composition, wherein the amount of the peeling agent (a') in the first composition is 0.05% by mass to 15% by mass relative to the total mass of the first composition; (2) On the skin, (b') at least one skin care active selected from skin lightening agents, skin anti-aging agents, skin moisturizing agents, and mixtures thereof; and (c) water applying a second composition comprising: the amount of (b') the skin care active ingredient in the second composition is 0.05% by weight to 10% by weight, based on the total weight of the second composition; applying a second composition, in which the amount of (c) water in the second composition is 50% by mass or more; Includes.

[0236] According to an even more preferred embodiment, the method according to the invention comprises the steps of: (1) On the skin, (a'') water-soluble particles, such as at least one peeling agent selected from sugars, polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof; applying a first composition comprising: the first composition is anhydrous; applying a first composition, wherein the amount of the peeling agent (a'') in the first composition is 0.1% by mass to 10% by mass relative to the total mass of the first composition; (2) On the skin, (b'') at least one skin care active selected from the group consisting of C-glycoside derivatives, hyaluronic acid and its salts, such as sodium hyaluronate, and mixtures thereof; and (c) water applying a second composition comprising: the amount of (b'') the skin care active ingredient in the second composition is 0.1% by weight to 5% by weight, based on the total weight of the second composition; applying a second composition, in which the amount of (c) water in the second composition is 60% by mass or more; Includes.

[0237] According to a preferred embodiment of another aspect of the invention, the method according to the invention comprises: (1) On the skin, (a) at least one peeling agent; (d) at least one oil other than a fatty alcohol; (e) at least one organic lipophilic gelling agent selected from urethane polymers, and (f) at least one aliphatic alcohol applying a first composition comprising: the first composition is anhydrous; the amount of the peeling agent (a) in the first composition is 0.01% by mass to 20% by mass relative to the total mass of the first composition; The amount of (d) oil in the first composition is 50% by mass or more based on the total mass of the first composition; the amount of (e) the lipophilic gelling agent in the first composition is 5% by mass or less, based on the total mass of the first composition; applying a first composition, wherein the amount of (f) aliphatic alcohol in the first composition is 0.1% by mass to 40% by mass relative to the total mass of the first composition; (2) On the skin, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: the amount of (b) the skin care active ingredient in the second composition is 0.01% by mass to 15% by mass, based on the total mass of the second composition; applying a second composition, wherein the amount of (c) water in the second composition is 40% by mass or more; Includes.

[0238] According to a more preferred embodiment of another aspect of the invention, the method according to the invention comprises: (1) On the skin, (a') at least one peeling agent selected from mechanical peeling agents and chemical peeling agents; (d') at least one oil selected from the group consisting of vegetable oils, ester oils, hydrocarbon oils, and mixtures thereof; (e') at least one organic lipophilic gelling agent selected from crosslinked urethane polymers, and (f') at least one aliphatic alcohol selected from branched aliphatic alcohols applying a first composition comprising: the first composition is anhydrous; the amount of the peeling agent (a') in the first composition is 0.05% by mass to 15% by mass relative to the total mass of the first composition; The amount of the oil (d') in the first composition is 60% by mass or more relative to the total mass of the first composition; the amount of the lipophilic gelling agent (e') in the first composition is 4% by mass or less, based on the total mass of the first composition; applying a first composition, wherein the amount of (f') aliphatic alcohol in the first composition is 0.5% by mass to 30% by mass relative to the total mass of the first composition; (2) On the skin, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: the amount of (b) the skin care active ingredient in the second composition is 0.05% by weight to 10% by weight, based on the total weight of the second composition; applying a second composition, in which the amount of (c) water in the second composition is 50% by mass or more; Includes.

[0239] According to an even more preferred embodiment of another aspect of the invention, the method according to the invention comprises: (1) On the skin, (a″) water-soluble particles, such as at least one peeling agent selected from sugars, polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof; (d'') at least one oil selected from the group consisting of vegetable oils such as jojoba oil, carbonate oils such as dicaprylyl carbonate, artificial triglyceride oils such as caprylic / capric triglyceride, hydrocarbon oils such as squalane, and mixtures thereof; (e'') HDI / trimethylolhexyl lactone crosspolymer, and (f'') at least one aliphatic alcohol selected from the group consisting of hexyldodecanol, octyldodecanol, and mixtures thereof applying a first composition comprising: the first composition is anhydrous; the amount of the peeling agent (a'') in the first composition is 0.1% by mass to 10% by mass relative to the total mass of the first composition; The amount of the oil (d'') in the first composition is 70% by mass or more, based on the total mass of the first composition; The amount of (e'') lipophilic gelling agent in the first composition is 3% by weight or less, based on the total weight of the first composition; applying a first composition, wherein the amount of (f'') aliphatic alcohol in the first composition is 1% by mass to 20% by mass relative to the total mass of the first composition; (2) On the skin, (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: the amount of (b) the skin care active ingredient in the second composition is 0.1% by weight to 5% by weight, based on the total weight of the second composition; applying a second composition, in which the amount of (c) water in the second composition is 60% by mass or more; Includes.

[0240] [kit] Another aspect of the invention is a kit for treating skin, comprising: (1) (a) at least one oil other than a fatty alcohol; a first compartment containing a first composition comprising: (2) (b) at least one skin care active ingredient, and (c) water a second compartment containing a second composition comprising Equipped with the first composition is anhydrous; The kit is one in which the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

[0241] The above explanations regarding components (a) to (c) and optional components of the method according to the present invention can be applied to the above explanations regarding the kit according to the present invention. The explanations regarding the preparation and form of the first and second compositions can also be applied to the first and second compositions described in the above kit according to the present invention.

[0242] The (a) peeling agent in the first composition in the kit according to the present invention may be selected from mechanical peeling agents, preferably from water-soluble particles, more preferably from water-soluble polysaccharide particles, such as sucrose particles.

[0243] On the other hand, the peeling agent (a) in the first composition in the kit according to the present invention may be selected from chemical peeling agents, preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, and more preferably polyhydroxy acids in the form of lactones such as gluconolactone.

[0244] A person skilled in the art can prepare the kit according to the present invention based on conventional packaging technology. The kit according to the present invention comprises at least a first and a second compartment, each of which contains a first and a second composition, respectively. The first and the second compartments may be equipped with a dispensing or discharging means such as a pump. The first and the second compartments may be contained separately in two separate containers. Alternatively, the first and the second compartments may be contained in a single container.

[0245] The kit according to the present invention may be used for non-therapeutic methods, preferably cosmetic methods, more preferably cosmetic methods for skin care.

[0246] The kit according to the invention can be used to carry out the method according to the invention.

[0247] For example, the kit can be used by the following steps. (i) dispensing or expelling a first composition from a first compartment; (ii) applying the first composition onto the skin; (iii) dispensing or expelling the second composition from the second compartment; and (iv) applying the second composition onto the skin.

[0248] The steps (i) to (iv) may be carried out individually and consecutively, in other words, the steps (i) to (iv) do not have to be carried out simultaneously.

[0249] If necessary, the following steps may be carried out between steps (ii) and (iv) above: (a) massaging or rubbing the first composition into the skin; and / or (b) removing the first composition from the skin; If necessary, the following step may be carried out after step (iv) above: (c) leaving the second composition on the skin for a specified period of time; and / or (d) removing the second composition from the skin. [Example]

[0250] The present invention will now be described in more detail by way of examples, which should not be construed as limiting the scope of the present invention.

[0251] (Example A and Comparative Example A) Each of the compositions according to Example A and Comparative Example A was prepared by mixing the ingredients shown in Table 1. All figures for the amounts of ingredients in Table 1 are based on "wt %" of the active material.

[0252] [Table 1]

[0253] (Examples B to C and Comparative Example B) Each of the compositions according to Examples B-C and Comparative Example B was prepared by mixing the ingredients shown in Table 2. All figures for the amounts of ingredients in Table 2 are based on "mass %" of the active material.

[0254] [Table 2]

[0255] [evaluation] (Penetration test) Permeation experiments were performed in Franz diffusion cells (PermeGear) using a Strat-M membrane (Merck, surface area 1.77 cm). 2 The device consisted of a donor and a receptor section, with a Strat-M membrane between the two sections. The receptor section was filled with a predetermined volume of receiving solution (0.25% by weight Tween 80 / deionized water) maintained at a temperature of 32°C, which was continuously stirred by a small magnetic bar.

[0256] Each composition according to Example A and Comparative Example A was applied at 5 mg / cm 2 The Strat-M membrane was gently rubbed for 1 minute.

[0257] A composition containing the ingredients shown in Table 3 below also contains 5 mg / cm 2All figures for component amounts in Table 3 are based on "wt %" of active material.

[0258] [Table 3]

[0259] After 16 hours, 200 μl of the receptor solution was removed from the receptor compartment, and the same amount of fresh receptor solution was added to the receptor compartment to maintain the same permeation conditions. The removed receptor solution was analyzed by HPLC to determine the amount of skin care active ingredient (hydroxypropyltetrahydropyrantriol) in the receptor solution.

[0260] The results are shown in the row "Amount of active ingredient penetrated" in Table 4 below.

[0261] [Table 4]

[0262] (Skin Finishing) Six trained panelists rated the "skin finish" according to the level of greasiness or oiliness.

[0263] As a first step, each panelist applied a 1 g amount of the composition according to Example A onto their skin. After 1 minute, each panelist evaluated the "skin finish" by ranking it from 1 (very poor) to 5 (very good).

[0264] Next, as a second step, each panelist applied 1 g of each composition according to Examples B-C and Comparative Example B onto their skin. After 1 minute, each panelist evaluated the "skin finish" by ranking it as 1 (very poor), 2 (poor), 3 (fair), 4 (good), or 5 (very good).

[0265] The results are shown in the "First Step" and "Second Step" rows in Table 5 below.

[0266] [Table 5]

[0267] Example 1 in Table 5 refers to a combination of a first step for applying a composition according to Example A and a second step for applying a composition according to Example B.

[0268] Example 2 in Table 5 refers to a combination of a first step for applying a composition according to Example A and a second step for applying a composition according to Example C.

[0269] Comparative Example 1 in Table 5 refers to a combination of a first step for applying the composition according to Example A and a second step for applying the composition according to Comparative Example B.

[0270] (summary) The composition according to Example A in Table 1 corresponds to the first composition in the method according to the invention.

[0271] The compositions according to Examples B and C in Table 2 and the compositions in Table 3 correspond to the second composition in the method according to the invention.

[0272] As shown in Table 4, (a) use of the composition according to Example A, which includes gluconolactone as a peeling agent, enhanced or improved (b) the penetration of hydroxypropyltetrahydropyrantriol as a skin care active ingredient, compared to use of the composition according to Comparative Example A, which does not include a peeling agent.

[0273] Furthermore, as shown in Table 5, the method carried out according to Example 1 or Example 2 could provide a good skin finish with reduced greasiness or oiliness because the amount of water in the second composition was 40% by weight or more relative to the total weight of the second composition, while the method carried out according to Comparative Example 1 could not provide a good skin finish because the amount of water in the second composition was less than 40% by weight relative to the total weight of the second composition.

Claims

1. 1. A method for treating skin, comprising: (1) on the skin (a) at least one peeling agent applying a first composition comprising: (2) on the skin (b) at least one skin care active ingredient, and (c) water applying a second composition comprising: Including, the first composition is anhydrous; The method, wherein the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

2. The method according to claim 1, wherein the (a) peeling agent is selected from mechanical peeling agents, preferably selected from water-soluble particles, more preferably selected from water-soluble polysaccharide particles, such as sucrose particles.

3. 2. The method according to claim 1, wherein the peeling agent (a) is selected from chemical peeling agents, preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, more preferably polyhydroxy acids in the form of lactones such as gluconolactone.

4. The method according to any one of claims 1 to 3, wherein the amount of the (a) peeling agent in the first composition is 0.01% by mass to 20% by mass, preferably 0.05% by mass to 15% by mass, and more preferably 0.1% by mass to 10% by mass, relative to the total mass of the first composition.

5. 5. The method of claim 1, wherein the first composition further comprises (d) at least one oil other than a fatty alcohol.

6. 6. The method of claim 1, wherein the first composition further comprises (e) at least one organic lipophilic gelling agent selected from urethane polymers.

7. 7. The method of claim 1, wherein the first composition further comprises (f) at least one fatty alcohol.

8. 8. The method of claim 1, wherein the (b) skin care active ingredient is selected from skin lightening agents, skin anti-aging agents, skin moisturizing agents, and mixtures thereof.

9. 9. The method of claim 1, wherein the (b) skin care active ingredient is selected from the group consisting of C-glycoside derivatives, hyaluronic acid and its salts, such as sodium hyaluronate, and mixtures thereof.

10. The (b) skin care active ingredient is C-beta-D-xylopyranoside-n-propan-2-one, C-alpha-D-xylopyranoside-n-propan-2-one, C-beta-D-xylopyranoside-2-hydroxypropane, C-alpha-D-xylopyranoside-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(C-alpha-D-glucopyranosyl)-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-aminopropane, 1-(C-alpha-D-glucopyranosyl)-2-aminopropane, 3'-(acetamido-C-beta-D-glucopyranosyl)propane 10. The method according to any one of claims 1 to 9, wherein the compound is selected from the group consisting of C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, preferably C-beta-D-xylopyranoside-2-hydroxypropane, 3'-(acetamido-C-alpha-D-glucopyranosyl)propan-2'-one, 1-(acetamido-C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(acetamido-C-beta-D-glucopyranosyl)-2-aminopropane, and salts thereof, solvates thereof, for example hydrates, and optical isomers thereof, preferably C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, more preferably C-beta-D-xylopyranoside-2-hydroxypropane.

11. 11. The method according to any one of claims 1 to 10, wherein the amount of the (b) skin care active ingredient in the second composition is from 0.01% to 15% by weight, preferably from 0.05% to 10% by weight, and more preferably from 0.1% to 5% by weight, relative to the total weight of the second composition.

12. 12. The method of claim 1, further comprising massaging or rubbing the skin between steps (1) and (2).

13. 1. A kit for treating skin, comprising: (1) (a) at least one peeling agent a first compartment containing a first composition comprising: (2) (b) at least one skin care active ingredient, and (c) water a second compartment containing a second composition comprising Equipped with the first composition is anhydrous; A kit, wherein the amount of (c) water in the second composition is 40% by mass or more, preferably 50% by mass or more, and more preferably 60% by mass or more, relative to the total mass of the second composition.

14. The kit according to claim 13, wherein the (a) peeling agent is selected from mechanical peeling agents, preferably selected from water-soluble particles, more preferably selected from water-soluble polysaccharide particles, such as sucrose particles.

15. 14. The kit according to claim 13, wherein the peeling agent (a) is selected from chemical peeling agents, preferably selected from polyhydroxy acids, monohydroxy acids, salts thereof, and mixtures thereof, more preferably polyhydroxy acids in the form of lactones such as gluconolactone.

Images