Bathing agent capable of enhancing atp production efficiency by intramuscular proteolysis by molecular hydrogen and promoting recovery from fatigue

Abstract

To provide a bathing agent particularly effective for reducing the feeling of fatigue of a bather and improving the vitality.SOLUTION: The bathing agent contains diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent. The hydrogen generating agent may be magnesium hydride. The content of the hydrogen generating agent may be 0.01% by mass or more and 20% by mass or less based on the total amount of the bath agent.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a bath additive, and more particularly to a bath additive that can increase the efficiency of ATP production through intramuscular protein breakdown by using molecular hydrogen and promote recovery from fatigue. [Background technology]

[0002] Known bath additives include carbonated bath additives that generate carbon dioxide gas by reacting with water, inorganic salt bath additives that exert specific effects by dissolving inorganic salts in water, and hydrogen bath additives that generate hydrogen by reacting with water. For example, a known hydrogen bath additive is one that contains calcium hydride (see Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-197435 Summary of the Invention [Problem to be solved by the invention]

[0004] Bath additives provide bathers with effects such as promoting blood circulation, relaxation, and moisturizing. The present inventors have conducted extensive research, focusing particularly on reducing the bather's sense of fatigue. That is, the present invention aims to provide a bath additive that is particularly effective in reducing the bather's sense of fatigue and improving their vitality. [Means for solving the problem]

[0005] The present invention includes, for example, the following aspects. [1] A bath additive containing diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent. [2] The bath additive according to [1], wherein the hydrogen generating agent is magnesium hydride. [3] The bath additive according to [1] or [2], wherein the content of the hydrogen generating agent is 0.01% by mass or more and 20% by mass or less, based on the total amount of the bath additive. [4] The bath additive according to any one of [1] to [3], wherein the content of the diamond nanoparticles is 1 mass % or less based on the total amount of the bath additive. [5] The bath additive according to any one of [1] to [4], wherein the content of the diamond nanoparticles is 0.1 mass % or less based on the total amount of the bath additive. [6] The bath additive according to any one of [1] to [5], wherein the content of the platinum nanoparticles is 1 mass % or less based on the total amount of the bath additive. [7] The bath additive according to any one of [1] to [6], wherein the content of the platinum nanoparticles is 0.1 mass % or less based on the total amount of the bath additive. [8] The bath additive according to any one of [1] to [7], wherein the mass ratio of the content of the platinum nanoparticles to the content of the diamond nanoparticles is 0.01 to 100. [9] An ATP production increaser comprising the bath additive according to any one of [1] to [8]. [Effects of the Invention]

[0006] According to the present invention, a bath additive can be provided that is particularly effective in reducing fatigue and increasing vitality in bathers. [Brief explanation of the drawings]

[0007] [Figure 1] FIG. 1 is a graph showing the measurement results of muscle temperature in Test 1. [Figure 2] FIG. 2 is a graph showing the measurement results of oxyhemoglobin levels in Test 1. [Figure 3] FIG. 3 is a graph showing the measurement results of the amount of deoxyhemoglobin in Test 1. [Figure 4] FIG. 4 is a graph showing the results of measurement of cortisol secretion in Test 1. [Figure 5] FIG. 5 is a graph showing the results of measurement of cortisol secretion in Test 2. DETAILED DESCRIPTION OF THE INVENTION

[0008] Hereinafter, embodiments of the present invention will be described, but the present invention is not limited to the following embodiments.

[0009] When used in a bath, the bath additive of this embodiment increases oxyhemoglobin and deoxyhemoglobin in the bather, which can be said to stimulate the supply and consumption of oxygen in the bather's body and stimulate muscle activity. Furthermore, when used in a bath, the bath additive of this embodiment increases the amount of cortisol secreted by the bather. This causes muscle protein to be broken down and amino acids to be supplied. The amino acids are used as materials for gluconeogenesis. Protein breakdown is an energy-consuming process that generates heat, which can be confirmed by the fact that the bather's muscle temperature is suppressed from decreasing. Amino acids and gluconeogenesis are converted to acetyl-CoA and supplied to the TCA cycle. NADH and FADH2 are produced through the TCA cycle, which are electron donors for ATP production in the electron transport chain. As evidenced by an increase in oxyhemoglobin, a sufficient supply of oxygen allows NADH to serve as the final electron acceptor of oxygen in the electron transport chain, resulting in efficient ATP production. Furthermore, as evidenced by an increase in deoxyhemoglobin, oxygen is consumed, stimulating metabolic activity. From these findings, it can be said that the bath additive of this embodiment, when used in a bath, promotes ATP production and enhances energy supply to the bather. Since one of the causes of fatigue is ATP depletion, the generation of ATP can reduce fatigue and improve vitality. In other words, the bath additive according to this embodiment can reduce fatigue and improve vitality in the bather.

[0010] The bath additive according to this embodiment contains at least diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent.

[0011] <Diamond nanoparticles> Diamond nanoparticles are nano-sized diamond particles with an average particle size of less than 1 μm. In this specification, the average particle size refers to the 50% volume average particle size (D50) (the same applies below). The average particle size is determined by dynamic light scattering (for example, a method of measuring using an electrophoretic light scattering photometer model ELS-8000).

[0012] As the diamond nanoparticles, for example, crude diamond (also called blended diamond or BD) synthesized by bombardment, and GD (Generated Diamond) obtained by refining BD can be used.

[0013] BDs produced by bombardment are composed of diamond and graphite particles with diameters ranging from tens to hundreds of nanometers. They are tightly aggregated aggregates of extremely small nanocluster-sized diamond units (diamond nanoparticles) with diameters ranging from 1.7 to 7 nm. BDs are tightly aggregated aggregates of at least four diamond nanoparticles, usually tens to hundreds, and sometimes thousands of diamond nanoparticles. BD particles are thought to have a core / shell structure in which the diamond surface is covered with graphite-based carbon. The graphite-based carbon surface may contain hydrophilic functional groups such as -COOH and -OH. When hydrophilic functional groups are present on the surface of graphite-based carbon, they have excellent affinity with solvents containing -OH groups, such as water, alcohol, and ethylene glycol, and are readily dispersible in these solvents. Dispersibility in water is particularly favorable. BDs may also contain ultrafine particles of amorphous diamond, graphite, and non-graphite carbon (1.5 nm or less).

[0014] The impurities in BD can be divided into (i) water-soluble electrolytes (ionized), (ii) hydrolyzable groups and ionic materials (such as salts of functional surface groups) hydrogen-bonded to the diamond surface, (iii) water-insoluble materials (surface-attached impurities, insoluble salts, insoluble oxides), (iv) volatile materials, and (v) materials that are incorporated or encapsulated within the diamond crystal lattice.

[0015] (i) and (ii) are formed during the GD purification process. The water-soluble electrolyte (i) can be removed by washing with water, but treatment with an ion exchange resin is preferred for more effective removal. The water-insoluble impurities (iii) consist of separated microparticles such as metals, metal oxides, metal carbides, and metal salts (sulfates, silicates, carbonates), inseparable surface salts, and surface metal oxides. To remove these, it is preferable to convert them to a soluble form using an acid. The volatile impurities (iv) can usually be removed by heat treatment at 250 to 400°C in a vacuum of about 0.01 Pa.

[0016] To obtain diamond nanoparticles, it is not necessary to completely remove the impurities from the BD, but it is preferable to remove 40 to 95% of the impurities (i) to (iii). The ratio of graphite to diamond can be adjusted by changing the conditions of the bombardment method and / or the purification conditions of the BD.

[0017] The GD is obtained as a dispersion of GD, which is produced by oxidizing a diamond-non-diamond mixture (initial BD) obtained by detonating an explosive, followed by neutralization with the addition of a basic material that is volatile or whose decomposition reaction products become volatile, and then separating the diamond-containing layer.

[0018] The oxidation treatment step comprises an oxidative decomposition treatment using nitric acid, followed by an oxidative etching treatment using nitric acid. The oxidative etching treatment comprises a first oxidative etching treatment and a second oxidative etching treatment, the first oxidative etching treatment being preferably carried out at a pressure and temperature higher than those of the oxidative decomposition treatment, and the second oxidative etching treatment being preferably carried out at a pressure and temperature higher than those of the first oxidative etching treatment. The oxidation treatment step is preferably carried out multiple times at 150°C to 250°C and 14 to 25 atmospheres for at least 10 to 30 minutes each.

[0019] After the oxidative etching process, a neutralization process is carried out to decompose and remove the nitric acid. The dispersion neutralized with a basic material is separated into a diamond-containing phase and a diamond-free phase by adding water and decanting.

[0020] After the diamond-containing phase is separated, the dispersion is further washed with nitric acid, and the lower phase dispersion containing the purified diamond particles is separated from the upper phase effluent. This separation is carried out by leaving the dispersion after the nitric acid washing treatment to stand.

[0021] The pH of the lower phase dispersion containing the purified diamond particles is preferably adjusted to 4 to 10, more preferably 5 to 8, and most preferably 6 to 7.5, and the diamond particle concentration is preferably adjusted to 0.05 to 16 mass %, more preferably 0.1 to 12 mass %, and most preferably 1 to 10 mass %.

[0022] The GD thus obtained has an elemental composition of 72-89.5% carbon, 0.8-1.5% hydrogen, 1.5-2.5% nitrogen, and 10.5-25% oxygen. Of the total carbon, 90-97% is diamond crystals, and 10-3% is non-diamond carbon. The average particle size (primary particles) is 2-50 nm. In the X-ray diffraction spectrum (XD) using Cu and Kα radiation as a radiation source, the Bragg angle (2Φ±0.2°) has the strongest peak at 43.9°, characteristic strong peaks at 73.5° and 95°, a strongly distributed halo at 17°, and essentially no peak at 26.5°. The specific surface area is 1.5×10 5 m 2 / kg or more, substantially all surface carbon atoms are bonded to heteroatoms, and the dispersion is 0.5m 3 The diamond particles have a total absorption space of 0.05 to 16 parts by mass, and the diamond particles have a total absorption space of 0.05 to 16 parts by mass. The particle size of the diamond particles is obtained by dynamic light scattering measurement using an electrophoretic light scattering photometer model ELS-8000.

[0023] The average particle size of the diamond nanoparticles may be 10 nm or more, 20 nm or more, or 100 nm or more, or may be 200 nm or less. The average particle size of the diamond nanoparticles may be 100 to 200 nm.

[0024] The specific gravity of diamond nanoparticles is 2.50-3.45g / cm 3 It is preferable that the density is 2.63 to 3.38 g / cm 3 More preferably, it is 2.75 to 3.25 g / cm 3 The specific gravity of diamond nanoparticles is determined by the ratio of graphite to diamond, and the specific gravity of diamond is set to 3.50 g / cm. 3 , the specific gravity of graphite is 2.25g / cm 3 Calculating the ratio of diamond to graphite, the specific gravity is 2.63g / cm 3 , the composition of the diamond nanoparticles corresponds to 30% diamond and 70% graphite by volume, and the specific gravity is 3.38 g / cm 3, the composition of the diamond nanoparticles corresponds to 90% diamond and 10% graphite by volume. Similarly, the specific gravity is 2.75 g / cm 3 , the composition of the diamond nanoparticles corresponds to 40% diamond and 60% graphite by volume, and the specific gravity is 3.25 g / cm 3 In this case, the composition of the diamond nanoparticles corresponds to 80% diamond and 20% graphite by volume. The specific gravity is 2.87 g / cm 3 The composition of the diamond nanoparticles corresponds to 50% diamond and 50% graphite by volume. 3 If it is less than 3.38 g / cm3, coloring due to graphite may become a problem. 3 Above this value, the far-infrared radiation effect is saturated, which is disadvantageous in terms of cost.

[0025] The content of diamond nanoparticles contained in the bath additives is preferably 0.0001% by mass or more, 0.001% by mass or more, 0.01% by mass or more, or 0.1% by mass or more, based on the total amount of the bath additive, from the viewpoint of excellent stimulation efficiency to the bather, more excellent effects of reducing fatigue and improving vitality, and from the viewpoint of suppressing aggregation of the diamond nanoparticles, it is preferably 10% by mass or less, 5% by mass or less, or 3% by mass or less, and from the viewpoint of excellent stimulation efficiency to the bather, more excellent effects of reducing fatigue and improving vitality, it is more preferably 1% by mass or less, 0.8% by mass or less, 0.5% by mass or less, or 0.3% by mass or less. The content of diamond nanoparticles contained in the bath additives may be 0.0001 to 10% by mass, based on the total amount of the bath additive.

[0026] <Platinum nanoparticles> Platinum nanoparticles are nano-sized platinum particles with an average particle size of less than 1 μm.

[0027] Platinum nanoparticles can be obtained as platinum nanocolloids, for example, by the method described below.

[0028] The method for producing platinum nanocolloids includes the steps of adding a peptide or glucosamine compound as a reducing agent, compound A represented by formula (1) or (2), to a solution in which a platinum-containing precious metal-containing compound has been dissolved; adding an alkali to assist the reducing properties of compound A; and forming precious metal particles (platinum particles) by a reduction reaction of the precious metal ions in the precious metal-containing compound. NR 4 R 5 -CR 2 R 3 -CO-R 1 (1) NR 4 R 5 -CR 6 R 7 -CR 2 R 3 -CO-R 1 (2)

[0029] where R 1 represents hydrogen, a hydroxyl group, an alkoxy group, an amino group, or an atomic group bonded by a peptide bond, and R 2 and R 3 each represents hydrogen, an alkyl group, or a substituted alkyl group, and R 4 and R 5 each represents a hydrogen atom, an alkyl group, a substituted alkyl group, or an acetyl group, and R 6 and R 7 represents hydrogen, an alkyl group or a substituted alkyl group.

[0030] In the method for producing platinum nanocolloid, preferably, the solution is an aqueous solution. More preferably, in the step of adding alkali, the alkali is added so that the pH of the aqueous solution is 10 or higher. Even more preferably, in the step of forming precious metal fine particles, the precious metal colloid is formed by dispersing precious metal fine particles in the aqueous solution. Even more preferably, after the step of forming precious metal fine particles to form the precious metal colloid, the method further includes a step of centrifuging the aqueous solution to separate it into a sediment and a supernatant, and a step of removing the supernatant and extracting the sediment.

[0031] In another preferred embodiment, the method for producing platinum nanocolloid is a solution in an organic solvent. More preferably, after the step of forming precious metal fine particles, the method further comprises the steps of allowing the solution to stand and separating it into a sediment and a supernatant, and removing the supernatant to extract the sediment. Even more preferably, after the step of removing the supernatant and extracting the sediment, the method further comprises the step of adding water to the sediment to form an aqueous precious metal colloid. Even more preferably, after the step of forming the precious metal colloid, the method further comprises the step of concentrating the precious metal colloid by ultrafiltration, ultracentrifugation, or the like. Even more preferably, the method further comprises the step of adding an organic solvent protective agent to the solution, and after the step of removing the supernatant and extracting the sediment, the method further comprises the step of adding an organic solvent to the sediment to form an organic solvent-based precious metal colloid.

[0032] The peptide compound A is a compound represented by the formula (1) or (2), 1 is an α-amino acid or β-amino acid in which R is a hydroxyl group, 1 an α-amino acid compound or a β-amino acid compound such as an α-amino acid ester or a β-amino acid ester in which R is an alkoxy group; an α-amino acid compound or a β-amino acid compound in which the amino group is acetylated; 1 Examples include peptides in which the N-terminus is an α-amino acid, which is an atomic group connected by a peptide bond.

[0033] The glucosamine compound, Compound A, is a compound represented by the formula (1), 1 is hydrogen and R 2 is [-CH(OH)-CH(OH)-CH(OH)-CH 2 (OH) ] and R 3 , R 4 , R 5 Examples of glucosamine compounds include glucosamine in which N is hydrogen, and its derivative N-acetylglucosamine.

[0034] The average particle size of the platinum nanoparticles may be 10 nm or more, 20 nm or more, or 100 nm or more from the viewpoint of providing excellent stimulation to the bather and more effective in reducing fatigue and improving vitality, or from the same viewpoint, may be 200 nm or less. The average particle size of the platinum nanoparticles may be 20 to 200 nm.

[0035] The content of platinum nanoparticles contained in the bath additives is 0.0001 mass% or more, 0.001 mass% or more, 0.01 mass% or more, or 0.1 mass% or more, based on the total amount of the bath additive, from the viewpoints of excellent stimulation efficiency for the bather and better effects of reducing fatigue and improving vitality, and is preferably 10 mass% or less, 5 mass% or less, or 3 mass% or less from the viewpoint of suppressing aggregation of the platinum nanoparticles, and more preferably 1 mass% or less, 0.8 mass% or less, 0.5 mass% or less, or 0.3 mass% or less from the viewpoints of excellent stimulation efficiency for the bather and better effects of reducing fatigue and improving vitality.

[0036] The mass ratio of platinum nanoparticles to diamond nanoparticles contained in the bath additive (platinum nanoparticle content / diamond nanoparticle content) is preferably 0.01 or more, 0.05 or more, 0.1 or more, or 0.3 or more, from the viewpoint of excellent stimulation efficiency for the bather and more effective effects of reducing fatigue and improving vitality, and from the same viewpoint, is preferably 100 or less, 20 or less, 10 or less, or 1 or less. The mass ratio may be 0.01 to 100.

[0037] <Hydrogen generating agent> A hydrogen generating agent is a compound that generates hydrogen (molecular hydrogen) by reacting with water. A hydrogen generating agent is also called a molecular hydrogen generating agent. Molecular hydrogen (H2) is more stable than atomic hydrogen (H). Furthermore, the stable generation of molecular hydrogen by a molecular hydrogen generating agent is expected to stably eliminate hydroxyl radicals of active oxygen. Furthermore, the presence of diamond nanoparticles and platinum nanoparticles together with the hydrogen generating agent facilitates the generation of molecular hydrogen, which can reduce fatigue and improve vitality in bathers. The hydrogen generating agent may be at least one selected from the group consisting of magnesium hydride, tetrahydroborate, and calcium hydride.

[0038] The hydrogen generating agent may be magnesium hydride. When the hydrogen generating agent is magnesium hydride, hydrogen is generated by the following reaction: MgH2+2H2O→Mg(OH)2+2H2

[0039] Magnesium hydroxide (Mg(OH)2), which is produced by the reaction of magnesium hydride with water, gels over time in the bath. To prevent this, bath additives may contain polyvalent aliphatic carboxylic acids.

[0040] Examples of polyvalent aliphatic carboxylic acids include divalent aliphatic carboxylic acids such as malic acid, fumaric acid, succinic acid, maleic acid, tartaric acid, oxalic acid, and malonic acid; and trivalent aliphatic carboxylic acids such as citric acid. From the viewpoint of formulation stability, the polyvalent aliphatic carboxylic acid may be an anhydride that does not contain water of crystallization. The mass ratio of the polyvalent aliphatic carboxylic acid to the magnesium hydride may be, for example, 5 to 20 times, or 10 to 15 times.

[0041] The average particle size of the magnesium hydride may be, for example, 0.1 to 1 μm from the viewpoints of reaction efficiency and dispersibility.

[0042] The hydrogen generating agent may comprise a tetrahydroborate salt.n+ [BH4] n where M represents a metal atom such as Li, Na, K, Rb, or Cs. When the tetrahydroborate salt is sodium tetrahydroborate, hydrogen is generated by the following reaction: NaBH4 + 2H2O → NaBO2 + 4H2

[0043] The hydrogen generating agent may be calcium hydride. When the hydrogen generating agent is calcium hydride, hydrogen is generated by the following reaction: CaH2+2H2O→Ca(OH)2+2H2

[0044] The average particle size of calcium hydride may be, for example, 1 to 20 mm from the viewpoints of reaction efficiency and dispersibility.

[0045] The hydrogen generating agent may be magnesium hydride, which is highly stable, has low risk to the human body, and is easy to control the reaction.

[0046] The content of the hydrogen generating agent contained in the bath additive is 0.01% by mass or more, 0.1% by mass or more, 0.5% by mass or more, or 1% by mass or more, based on the total amount of the bath additive, from the viewpoint of providing excellent stimulation efficiency to the bather and more effective effects of reducing fatigue and improving vitality. Also, from the same viewpoint, it is preferably 20% by mass or less, 10% by mass or less, 5% by mass or less, or 3% by mass or less. From the same viewpoint, the content of magnesium hydride contained in the bath additive may be within the above range. The content of the hydrogen generating agent contained in the bath additive may be 0.01% by mass or more and 20% by mass or less, based on the total amount of the bath additive.

[0047] The mass ratio of the hydrogen generating agent to the diamond nanoparticles contained in the bath additive (hydrogen generating agent content / diamond nanoparticle content) is preferably 0.01 or more, 0.1 or more, 1 or more, or 5 or more, from the viewpoint of excellent stimulation efficiency for the bather and more effective effects of reducing fatigue and improving vitality, and from the same viewpoint, is preferably 100 or less, 50 or less, 20 or less, or 10 or less. The mass ratio may be 0.01 to 100.

[0048] The mass ratio of the hydrogen generating agent to the platinum nanoparticles contained in the bath additive (hydrogen generating agent content / platinum nanoparticle content) is preferably 0.01 or more, 0.1 or more, 1 or more, or 10 or more, from the viewpoint of excellent stimulation efficiency for the bather and more effective effects of reducing fatigue and improving vitality, and from the same viewpoint, is preferably 100 or less, 70 or less, 50 or less, or 30 or less. The mass ratio may be 0.01 to 100.

[0049] The bath additive according to this embodiment may contain an inorganic salt to improve moldability when forming the bath additive into a powder, tablet, block, or other form. Examples of inorganic salts include sodium salts, magnesium salts, and potassium salts. The bath additive may contain a single inorganic salt or multiple inorganic salts.

[0050] Examples of sodium salts include sodium carbonate, sodium bicarbonate, sodium sulfate, sodium chloride, and sodium nitrate. Examples of magnesium salts include magnesium carbonate, magnesium sulfate, magnesium chloride, and magnesium nitrate. Examples of potassium salts include potassium carbonate, potassium chloride, and potassium nitrate. Of these, sodium sulfate and sodium chloride are preferred because they have excellent heat-retaining properties. Furthermore, of these, sodium bicarbonate is preferred because it has a skin-cleansing effect and the carbon dioxide gas generated from sodium bicarbonate has the effect of raising body temperature. Furthermore, of these, magnesium sulfate is preferred because it has the effect of raising core body temperature and makes it easier to maintain a high body temperature even after bathing.

[0051] The content of inorganic salts contained in the bath additives is 20% by mass or more, 40% by mass or more, 50% by mass or more, or 60% by mass or more, based on the total amount of the bath additives, from the viewpoint of improving the stability of the shape of the bath additives, and is preferably 90% by mass or less, 80% by mass or less, or 70% by mass or less, from the viewpoint of improving the solubility of the bath additives in water.

[0052] The bath additive according to this embodiment may further contain an organic acid, an organic acid salt, an organic acid ester, a water-soluble polymer, an oil, or the like.

[0053] Examples of organic acids include maleic acid, malonic acid, benzoic acid, succinic acid, suberic acid, fumaric acid, lactic acid, mandelic acid, malic acid, phthalic acid, citric acid, tartaric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, and isostearic acid. Examples of organic acid salts include sodium salts, magnesium salts, and potassium salts of the above organic acids. Examples of organic acid esters include cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, and cholesterol isostearate.

[0054] From the viewpoint of reaction efficiency, the total content of organic acids, organic salts, and organic acid esters contained in the bath additives is, based on the total amount of the bath additives, 5% by mass or more, 10% by mass or more, 15% by mass or more, or 20% by mass or more, and from the viewpoint of reaction efficiency, preferably 50% by mass or less, 40% by mass or less, or 30% by mass or less.

[0055] Examples of water-soluble polymers include gelatin, gum arabic, guar gum, tragacanth gum, starch, polyacrylic acid, sodium polyacrylate, glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, locust bean gum, karaya gum, quince seed, casein, sodium alginate, polyvinyl alcohol, carboxyvinyl polymer, and hyaluronic acid.

[0056] From the viewpoint of reaction efficiency, the content of the water-soluble polymer contained in the bath additive is, based on the total amount of the bath additive, 0.001 mass% or more, 0.01 mass% or more, 0.1 mass% or more, or 0.5 mass% or more, and from the viewpoint of reaction efficiency, preferably 30 mass% or less, 20 mass% or less, 10 mass% or less, or 1 mass% or less.

[0057] Examples of fats and oils include soybean oil, rice bran oil, jojoba oil, avocado oil, almond oil, olive oil, rosehip oil, camellia oil, cocoa butter, shea butter, sesame oil, persic oil, castor oil, and coconut oil.

[0058] From the viewpoint of reaction efficiency, the content of fats and oils contained in the bath additives is, based on the total amount of the bath additives, 0.0001% by mass or more, 0.001% by mass or more, or 0.01% by mass or more, and from the viewpoint of reaction efficiency, preferably 10% by mass or less, 1% by mass or less, 0.1% by mass or less, or 0.01% by mass or less.

[0059] In addition to the above components, the bath additives according to this embodiment may contain fragrances, pigments, surfactants, excipients, alcohols, anti-inflammatory agents, vitamins, preservatives, antibacterial agents, deodorizers, pH adjusters (pH buffers), cooling agents, moisturizers, etc. The total content of these components may be 0.001% by mass or more, 0.01% by mass or more, or 0.1% by mass or more, based on the total amount of the bath additive, and may be 20% by mass or less, 10% by mass or less, 5% by mass or less, or 1% by mass or less.

[0060] Bath additives are dissolved in water before use. For example, adding 40 g of bath additives to 150 to 200 L of water can provide sufficient benefits. Furthermore, bathing in water containing the dissolved bath additives for 15 minutes or longer can provide sufficient benefits. The water temperature during bathing may be, for example, 36 to 44°C or 37 to 40°C.

[0061] Bathing in a bathtub containing the bath additive of this embodiment dissolved in water increases oxyhemoglobin and deoxyhemoglobin. Bathing in a bathtub containing the bath additive of this embodiment dissolved in water also increases cortisol secretion, promoting the breakdown of muscle proteins and producing amino acids. Bathing in a bathtub containing the bath additive of this embodiment dissolved in water also produces ATP. Bathing in a bathtub containing the bath additive of this embodiment dissolved in water also reduces the bather's sense of fatigue. Therefore, the present invention can be rephrased as an oxyhemoglobin increaser, a deoxyhemoglobin increaser, a cortisol secretion increaser, an ATP production increaser, and a fatigue reducer, all of which are composed of a bath additive containing diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent.

[0062] In addition, another embodiment of the present invention provides a method for increasing oxyhemoglobin, a method for increasing deoxyhemoglobin, a method for increasing cortisol secretion, a method for increasing ATP production, and a method for reducing fatigue, which includes applying a bath additive containing diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent. [Example]

[0063] The present invention will be described in more detail below with reference to examples and comparative examples, although the present invention is not limited to the following examples.

[0064] <Preparing bath additives> [Example 1] Based on the composition shown in Table 1, the mixture was heated and uniformly stirred using a stirrer, and then 40 g of the mixture was formed into tablets with a diameter of 40 mm at a tableting pressure of 1 ton to obtain bath additives. Each bath additive tablet weighed 40 g, and one tablet was used per bath. The bathing conditions were a 20-minute bath in 200 L of water at 40°C.

[0065] [Table 1]

[0066] <Test 1: Evaluation of the effect of bathing with bath additives on oxidative stress> Twenty healthy adults (aged 18 years or older) who regularly take baths were surveyed. Cortisol levels were measured using salivary stress markers, and oxyhemoglobin and deoxyhemoglobin levels were measured using oxidative stress markers. After measuring these markers, participants were given bath additives and instructed to use them daily for two weeks. Marker measurements were conducted three times in a crossover comparative study, with a bath additive trial and a control trial, with a one-week interval between trials.

[0067] <Test 2: Evaluation of physiological responses during bathing using bath additives> Healthy adults (aged 18 years or older) who regularly bathe were asked to wear swimsuits when bathing. Before entering the bath, they poured water over their lower legs, keeping both arms above the water surface to allow for continued bathing, and immersed in the bathtub in an extended kneeling position (knees extended). The water temperature was adjusted to maintain an average sublingual temperature of 39°C throughout the experiment. The amount of water was adjusted to ensure the water level was at nipple level. Measurements were spread out between 9:00 AM and 4:00 PM to avoid bias toward a specific time period. Subjects were also instructed not to eat within two hours before measurements began. Participants sat quietly for 30 minutes before entering the bath. After 15 minutes in the bath, they left the bath and quickly dried their bodies with a towel. They were then observed in a quiet sitting position for approximately 1 hour. Thigh skin blood flow was measured using a laser blood flowmeter (OMEGAFLO, Omegawave). Muscle oxygenation in the thigh (vastus lateralis) was measured using a near-infrared laser tissue blood monitor (OMEGAMONITOR BOM-L1TRW, Omegawave). Muscle temperature was measured using a TERUMO CoreTemp. Before and 1 hour after leaving the bath, cortisol was measured using a salivary stress marker, and oxyhemoglobin and deoxyhemoglobin levels were measured using oxidative stress markers. Marker measurements were performed once for the bath additive trial and once for the control trial, with a 1-week interval between trials.

[0068] <Evaluation results> (Test 1: Muscle temperature measurement) The results of muscle temperature measurements in Test 1 are shown in Figure 1. Muscle temperature measurements were taken every two minutes for 20 minutes from immediately after bathing until leaving the bath, and for 20 minutes after leaving the bath, using a heat flow compensation thermometer (Coretemp, manufactured by TERUMO Corporation).

[0069] (Test 1: Measurement of oxyhemoglobin content) The results of oxyhemoglobin measurement in Test 1 are shown in Figure 2. Oxyhemoglobin measurement was performed on the thigh (vastus lateralis muscle) using a near-infrared laser tissue blood monitor (OMEGAMONITOR BOM-L1TRW, manufactured by Omegawave Inc.) every two minutes for 20 minutes from immediately after bathing until leaving the bath, and for 20 minutes after leaving the bath.

[0070] (Test 1: Measurement of deoxyhemoglobin content) The results of the deoxyhemoglobin measurement in Test 1 are shown in Figure 3. Deoxyhemoglobin was measured every two minutes in the thigh (vastus lateralis) using a near-infrared laser tissue blood monitor (OMEGAMONITOR BOM-L1TRW, manufactured by Omegawave Inc.) for 20 minutes from immediately after bathing until leaving the bath, and for 20 minutes after leaving the bath.

[0071] (Test 1: Measurement of cortisol secretion) The results of measuring the amount of cortisol secretion in Test 1 are shown in Figure 4. The amount of cortisol secretion was measured immediately before bathing and 20 minutes after leaving the bath.

[0072] (Test 2: Measurement of cortisol secretion) The results of measuring cortisol secretion in Test 2 are shown in Figure 5. Cortisol secretion was measured three times: before the start of Test 2, after using the bath additives for two weeks, and after bathing in plain water for one week after using the bath additives.

Claims

1. A bath additive containing diamond nanoparticles, platinum nanoparticles, and a hydrogen generating agent.

2. 2. The bath additive according to claim 1, wherein the hydrogen generating agent is magnesium hydride.

3. 3. The bath additive according to claim 1, wherein the content of the hydrogen generating agent is 0.01% by mass or more and 20% by mass or less based on the total amount of the bath additive.

4. 3. The bath additive according to claim 1, wherein the content of the diamond nanoparticles is 1% by mass or less based on the total amount of the bath additive.

5. 3. The bath additive according to claim 1, wherein the content of the diamond nanoparticles is 0.1 mass % or less based on the total amount of the bath additive.

6. 3. The bath additive according to claim 1, wherein the content of the platinum nanoparticles is 1% by mass or less based on the total amount of the bath additive.

7. 3. The bath additive according to claim 1, wherein the content of the platinum nanoparticles is 0.1 mass% or less based on the total amount of the bath additive.

8. 3. The bath additive according to claim 1, wherein the mass ratio of the content of said platinum nanoparticles to the content of said diamond nanoparticles is 0.01 to 100.

9. An agent for increasing ATP production, comprising the bath additive according to claim 1 or 2.

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