Oral composition

Abstract

To provide an oral composition excellent in retention of fluoride ions and capable of suppressing formation of a viscous material.SOLUTION: The oral composition contains (A) sodium fluoride, (B) a water-soluble calcium salt, (C) at least one kind selected from the group consisting of condensed phosphoric acids and salts thereof, and (D) a zinc ion source.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Fluorides such as sodium fluoride are widely used as medicinal ingredients in oral compositions such as dentifrices because of their caries prevention effect. To ensure that fluoride acts effectively, it is effective to retain fluoride ions on the oral mucosa and tooth surfaces for a long period of time, and it is desirable to leave many fluoride ions in the oral cavity even after gargling and rinsing with water after use.

[0003] Patent Document 1 proposes a method of making calcium ions, fluoride ions, and phosphate ions coexist as a method of improving retention of fluoride ions. Patent Document 2 proposes a liquid oral composition that contains sodium fluoride (A), calcium glycerophosphate (B), condensed phosphoric acid or its salt (C), and a cationic bactericide (D), and that combines excellent fluoride retention with a sustained bactericidal effect against caries-causing bacteria, making it effective in preventing or suppressing dental caries. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2009-137863 [Patent Document 2] Japanese Patent Application Laid-Open No. 2017-66036 Summary of the Invention [Problem to be solved by the invention]

[0005] However, according to the inventor's findings, while the formation of a complex between the (A), (B), and (C) components increases the retention of fluoride ions, it may also result in the formation of a viscous substance. If a viscous substance forms on the cap or cap fitting portion of a container containing an oral composition, this may impair the smoothness of opening and closing the cap. An object of the present invention is to provide an oral composition that has excellent retention of fluoride ions and can suppress the formation of viscous substances. [Means for solving the problem]

[0006] The present invention has the following aspects. [1] An oral composition comprising: (A) component: sodium fluoride; (B) component: a water-soluble calcium salt; (C) component: at least one selected from the group consisting of condensed phosphoric acid and salts thereof; and (D) component: a zinc ion source. [2] The oral composition according to [1], wherein the component (B) comprises one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. [3] The oral composition according to [1] or [2], wherein the component (C) comprises one or more selected from the group consisting of sodium tripolyphosphate, pyrophosphate, and alkali metal pyrophosphate. [4] The oral composition according to any one of [1] to [3], wherein the component (D) comprises one or more selected from the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate, and zinc laurate. [5] The oral composition according to any one of [1] to [4], wherein (B) / (D), which represents the molar ratio of the component (B) to the component (D), is 0.01 to 300. [Effects of the Invention]

[0007] According to the present invention, an oral composition can be obtained which has excellent retention of fluoride ions and can suppress the formation of viscous substances. DETAILED DESCRIPTION OF THE INVENTION

[0008] As used herein, "oral composition" means a composition intended primarily for use in the oral cavity. In this specification, "water-soluble" means that the solubility in water at 20°C is 1 g / 100 g or more. In this specification, the use of "to" to indicate a range of values ​​means that the values ​​before and after it are included as the lower and upper limits.

[0009] [Oral composition] The oral composition of the present invention contains component (A), component (B), component (C), and component (D).

[0010] <Component (A)> Component (A) is sodium fluoride (NaF). Component (A) is a source of fluoride ions that have caries prevention effects. Component (A) can be a commercially available product.

[0011] <(B) component> Component (B) is a water-soluble calcium salt. Component (B) may be used alone or in combination of two or more. Component (B) can be a commercially available product. Component (B) preferably includes component (B1), which is one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. The proportion of the (B1) component relative to the total mass of the (B) component may be, for example, 90 mass% or more, 95 mass% or more, 96 mass% or more, 97 mass% or more, 98 mass% or more, or 99 mass% or more, or may be 100 mass%.

[0012] <(C) component> Component (C) is at least one selected from the group consisting of condensed phosphoric acid and salts thereof. Component (C) may be a combination of two or more types. Component (C) can be a commercially available product.

[0013] As the condensed phosphoric acid or a salt thereof, a water-soluble condensed phosphoric acid or a salt thereof can be preferably used. Examples of condensed phosphoric acid include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid; and cyclic polyphosphoric acids such as trimetaphosphoric acid, tetrametaphosphoric acid, and hexametaphosphoric acid. The salt of condensed phosphoric acid is preferably an alkali metal salt, such as a sodium salt or a potassium salt.

[0014] Component (C) preferably includes component (C1), which is one or more selected from the group consisting of sodium tripolyphosphate, pyrophosphate, and alkali metal pyrophosphate. Examples of component (C1) include potassium pyrophosphate, sodium pyrophosphate, and sodium tripolyphosphate. The proportion of the (C1) component relative to the total mass of the (C) component may be, for example, 90 mass% or more, 95 mass% or more, 96 mass% or more, 97 mass% or more, 98 mass% or more, or 99 mass% or more, or may be 100 mass%.

[0015] <(D) component> Component (D) is a zinc ion source. Component (D) is preferably a water-soluble zinc compound. Component (D) may be a single compound or a combination of two or more compounds. Component (D) can be a commercially available product.

[0016] Component (D) preferably includes component (D1), which is one or more members selected from the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate, and zinc laurate. The proportion of the (D1) component relative to the total mass of the (D) component may be, for example, 90 mass% or more, 95 mass% or more, 96 mass% or more, 97 mass% or more, 98 mass% or more, or 99 mass% or more, or may be 100 mass%.

[0017] <Content of each ingredient> The content of component (A) is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass, based on the total mass of the oral composition. When the content of component (A) is equal to or greater than the above lower limit, the fluoride ion retention is superior. When the content of component (A) is equal to or less than the above upper limit, the flavor is superior.

[0018] The content of component (B) is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass, based on the total mass of the oral composition. When the content of component (B) is equal to or greater than the lower limit, fluoride ion retention is improved. When the content of component (B) is equal to or less than the upper limit, flavor is improved. In addition, the formation of viscous substances is easily suppressed.

[0019] The content of component (C) is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass, based on the total mass of the oral composition. When the content of component (C) is equal to or greater than the above lower limit, the fluoride ion retention is better. When the content of component (C) is equal to or less than the above upper limit, the flavor is better.

[0020] The content of component (D) is preferably 0.001 to 10% by mass, more preferably 0.01 to 2% by mass, based on the total mass of the oral composition. When the content of component (D) is equal to or greater than the lower limit, the effect of inhibiting the formation of viscous substances (viscous substance formation inhibitory property) is more excellent. When the content of component (D) is equal to or less than the upper limit, the flavor is more excellent. The molar amount of zinc ions per 1 g of oral composition (unit: mmol / g) is Zn mmol Zn mmol is preferably 0.0001 to 0.73 mmol / g, more preferably 0.0007 to 0.15 mmol / g.

[0021] The molar ratio of the component (B) to the component (A) (hereinafter also referred to as "(B) / (A)") is preferably 0.01 to 10.0, more preferably 0.05 to 5.0. When (B) / (A) is within the above range, the fluoride ion retention is more excellent.

[0022] The molar ratio of the component (C) to the component (A) (hereinafter also referred to as "(C) / (A)") is preferably 0.005 to 1.5, more preferably 0.01 to 1.3. When the ratio (C) / (A) is within the above range, the retention of fluoride ions is more excellent.

[0023] The molar ratio of the (B) component to the (D) component (hereinafter also referred to as "(B) / (D)") is preferably 0.01 to 300, more preferably 0.1 to 150. When (B) / (D) is equal to or greater than the above lower limit, the flavor is more excellent. When (B) / (D) is equal to or less than the above upper limit, the effect of inhibiting the formation of viscous substances (viscous substance formation inhibiting property) is more excellent.

[0024] <Water> The oral composition typically further contains water, such as purified water, sterilized purified water, and water for injection. The content of water in the oral composition can be appropriately set depending on the product form and method of use of the oral composition. For example, when the oral composition is a liquid preparation, the content of water relative to the total mass of the oral composition is preferably 10 to 99 mass%, more preferably 20 to 95 mass%, and even more preferably 30 to 90 mass%. For example, when the oral composition is a toothpaste, the content of water relative to the total mass of the oral composition is preferably 5 to 90 mass%, more preferably 10 to 60 mass%, and even more preferably 20 to 50 mass%.

[0025] <Other ingredients> The oral composition may further contain other components in addition to the components (A), (B), (C), (D) and water. The other components can be appropriately selected from known components taking into consideration the form and method of use of the oral composition, etc. Examples of the other components include liquid media other than water, humectants, thickeners, surfactants, colorants, sweeteners, flavorings, active ingredients, pH adjusters, preservatives, abrasives, etc. In addition, when the oral composition is a product to be used in a liquid state, it is preferable that it is a liquid composition in which the ingredients are dissolved or uniformly dispersed, and it is preferable that it does not contain solid ingredients such as abrasives that cannot be solubilized.

[0026] Examples of liquid media other than water include polyhydric alcohols that are liquid at 20° C., such as glycerin, propylene glycol, and polyethylene glycol, and lower monohydric alcohols having 2 or 3 carbon atoms, such as ethanol. The polyhydric alcohol is preferably added because it acts as a humectant. When a polyhydric alcohol is added, its content is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, based on the total mass of the oral composition.

[0027] Lower monohydric alcohols are suitable for providing a refreshing and cool feeling during use, but if the content exceeds 20%, they can be irritating and may reduce the feeling of use.Alcohol-free oral compositions that are substantially free of lower monohydric alcohols (content of 0.1% by mass or less of the entire oral composition) are suitable as low-irritation oral compositions.

[0028] As the wetting agent, in addition to the polyhydric alcohols, sugar alcohols such as sorbitol, maltitol, lactitol, etc. can be mentioned. The content of the humectant, in total including the polyhydric alcohol, is preferably 2 to 20% by mass, more preferably 3 to 20% by mass, based on the total mass of the oral cavity composition.

[0029] Examples of thickeners include cellulose derivatives such as sodium carboxymethylcellulose and cationized cellulose, xanthan gum, and sodium alginate. The content of the thickener is preferably 0 to 5% by mass, more preferably 0.01 to 4% by mass, based on the total mass of the oral composition.

[0030] As the surfactant, known anionic surfactants, nonionic surfactants, cationic surfactants and amphoteric surfactants can be blended. Examples of anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinates such as sodium N-lauroyl sarcosinate and sodium N-myristoyl sarcosinate, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamates such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyltaurate, sodium N-methyl-N-acylalanine, and sodium α-olefin sulfonate. Examples of nonionic surfactants include sugar alcohol fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, maltitol fatty acid esters, and lactol fatty acid esters; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil; alkylolamides, polyoxyethylene sorbitan fatty acid esters, polyglycerin fatty acid esters, hexaglyceryl monocetylate, fatty acid diethanolamides, sorbitan fatty acid esters, and polyoxyethylene higher alcohol ethers. Examples of cationic surfactants include alkylammonium salts and alkylbenzylammonium salts. Examples of amphoteric surfactants include betaine acetate surfactants and imidazoline surfactants.

[0031] As coloring agents, safe water-soluble dyes such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105 can be added. Examples of sweeteners include xylitol, maltitol, saccharin, saccharin sodium, stevioside, and aspartame.

[0032] Fragrances include, for example, natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, lavender oil, and paracles oil; Fragrance components contained in the above natural essential oils, such as l-menthol, l-carvone, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, eugenol, menthyl acetate, citral, camphor, borneol, pinene, and spilanthol; Fragrance ingredients such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / delta-decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate; Examples include blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc., which are made by combining two or more types of flavoring ingredients and natural essential oils. One type of flavoring may be used, or two or more types may be used in combination. The content of the flavoring agent is preferably 0.00001 to 3% by mass relative to the total mass of the oral composition.

[0033] Examples of active ingredients that can be added include enzymes such as dextranase and mutanase, nonionic disinfectants such as isopropyl methylcellulose, polyglutamates, allantoin or its derivatives, azulene, lysozyme chloride, vitamins such as ascorbic acid, glycyrrhetin salts, plant extracts such as chlorophyll, copper chlorophyllin sodium, and thyme, copper gluconate, potassium nitrate, and aluminum lactate. The content of these active ingredients can be an effective amount within a range that does not impair the effects of the present invention.

[0034] Examples of pH adjusters include citric acid, tartaric acid, malic acid, phosphoric acid, carbonic acid, and salts thereof (potassium salt, sodium salt, ammonium salt), ribonucleic acid and salts thereof, sodium hydroxide, and the like.

[0035] Examples of preservatives include parahydroxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, and benzoic acid or a salt thereof such as sodium benzoate.

[0036] Examples of abrasives include silica-based abrasives such as silicic acid anhydride, precipitated silica, silica gel, aluminosilicate, and zirconosilicate; dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, tetrabasic calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, tribasic magnesium phosphate, and magnesium carbonate. Silica-based abrasives are particularly preferred. The content of the abrasive is, for example, preferably 0 to 60% by mass, more preferably 0 to 30% by mass, and may be 25% by mass or less, relative to the total mass of the oral composition. An abrasive content of 0% by mass means that no abrasive is contained.

[0037] <Form, dosage form> The oral composition can be prepared in various forms, for example, liquid, paste, gel, or solid. The dosage form of the oral composition is not particularly limited. The dosage form of the oral composition is typically an oral preparation that is expelled from the oral cavity after use. Examples of oral preparations include dentifrices (liquid dentifrices, toothpastes, lubricating dentifrices, powder dentifrices, etc.), mouthwashes, gargles, liniments, mouth sprays, patches, sheets, oral sustained-release preparations, chewable preparations, oral dissolving preparations, oral disintegrating preparations, tongue care preparations, mouth fresheners, denture care preparations, etc. The oral composition of this embodiment is suitable as a liquid preparation. The liquid preparation may be a liquid preparation of a concentrated type that is used as is, or a liquid preparation of a concentrated type that is diluted before use. Liquid preparations include undiluted mouthwashes, concentrated mouthwashes, undiluted liquid dentifrices, concentrated liquid dentifrices, undiluted mouthwashes, concentrated mouthwashes, undiluted mouth sprays, liquid preparations dispensed in foam form, etc. Liquid preparations other than liquid dentifrices do not usually contain non-solubilizable solid components such as abrasives.

[0038] The liquid preparation may be in the form of a product housed in a container having a cap attached to the opening of the container body for taking out the liquid preparation from the container body, for example. Examples of the cap include a screw cap, a toggle cap, a push-pull cap, a pump, etc. In particular, a toggle cap is preferred because the formation of a viscous substance makes the cap difficult to open and close, and the application of the present invention is particularly effective. A toggle cap has a toggle button attached to a cap body, for example, in a pivotal manner. The cap body has a liquid flow path communicating with the inside of the container, and the toggle button has an outlet for discharging the liquid and a liquid flow path connecting the outlet to the liquid flow path of the cap body. In a toggle cap, by operating the toggle button to switch between a position where the outlet is exposed to the outside and a position where the outlet is covered, it is possible to switch between discharging and stopping the discharge of the liquid from the container. For example, known toggle caps described in Japanese Utility Model Laid-Open Publication No. 49-114015, Japanese Patent Publication No. 8-510978, Japanese Patent Publication No. 7154003, etc. can be used.

[0039] For example, the pH of the undiluted mouthwash at 25°C is preferably 5.5 to 8.0, more preferably 6.0 to 7.5. For example, the viscosity of the undiluted mouthwash at 25°C is preferably 1 to 100 mPa·s, more preferably 2 to 50 mPa·s, and even more preferably 3 to 30 mPa·s. In this specification, the viscosity of the oral composition is a value measured with a Brookfield viscometer.

[0040] The oral composition of this embodiment can be prepared by a known method, for example, by mixing components (A), (B), (C), and (D), and optionally other components, by a conventional method.

[0041] In the oral cavity composition, fluoride ions, calcium ions, and phosphorus ions form a complex, and the complex contributes to improving the retention of fluoride ions. The method for forming the above-mentioned complex is not particularly limited, but when preparing the oral composition, it is preferable to adopt, for example, a process of blending component (A) and component (C) and then blending component (B), or a process of blending component (B) and component (C) and then blending component (A). Note that if component (A) and component (B) are blended simultaneously, calcium fluoride may be partially produced, which may result in a lower efficiency of complex formation.

[0042] The oral composition described above contains components (A), (B), and (C), and therefore has excellent fluoride ion retention properties, and the inclusion of component (D) suppresses the formation of viscous substances. [Example]

[0043] The present invention will be described in detail below with reference to examples, but the present invention is not limited to the following description. In the following examples, the unit of content "%" refers to "% by mass" unless otherwise specified.

[0044] <Raw materials used> [Component (A)] Sodium fluoride: manufactured by Stella Chemifa Co., Ltd. Also referred to as "NaF" hereinafter.

[0045] [(B) Component] Calcium lactate hydrate: trade name "Calcium lactate" manufactured by Taihei Chemical Industry Co., Ltd. Also referred to as "Ca lactate" hereinafter. Calcium gluconate: manufactured by Fuso Chemical Co., Ltd. Hereinafter also referred to as "Calcium gluconate." Calcium glycerophosphate: manufactured by Iwaki Pharmaceutical Co., Ltd. Hereinafter also referred to as "calcium glycerophosphate." Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Hereinafter also referred to as "Ca chloride." Calcium pantothenate: manufactured by BASF. Hereinafter also referred to as "Ca pantothenate."

[0046] [(C) component] Tetrapotassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "K pyrophosphate." Sodium pyrophosphate: Taihei Chemical Industry Co., Ltd., product name "Sodium pyrophosphate (anhydrous)". Hereinafter, also referred to as "Na pyrophosphate". Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "sodium tripolyphosphate."

[0047] [(D) component] Zinc chloride: manufactured by Junsei Chemical Co., Ltd. Zinc gluconate: manufactured by Tokyo Chemical Industry Co., Ltd. Zinc stearate: Manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. Zinc myristate: manufactured by NOF Corporation. Zinc laurate: Manufactured by Tokyo Chemical Industry Co., Ltd.

[0048] [water] Purified water. [Common component (arbitrary component)] Glycerin (liquid medium) 7.5%, propylene glycol (liquid medium) 3%, sorbitol (humectant) 5%, citric acid (pH adjuster) 0.1%, sodium citrate (pH adjuster) 0.2%, fragrance 0.2%. Total 16.0%.

[0049] <Examples 1 to 25 and Comparative Examples 1 to 4> Oral compositions (mouthwashes) having the compositions shown in Tables 1 to 4 were prepared by conventional methods. The components were mixed in the following order to prepare a preliminary mixed solution: an aqueous solution of component (C), an aqueous solution of component (B), and an aqueous solution of component (A). The amount of water was the amount necessary to obtain the composition shown in the table. The aqueous solution of component (D) and optional components were added to this preliminary mixed solution and mixed at room temperature to obtain an oral composition. The pH of the oral composition at 25°C was within the range of 6 to 7. In all examples, the viscosity of the oral composition at 25°C was within the range of 4±1 mPa·s. A blank space in the table indicates that the component is not blended. The "balance" of purified water indicates the amount that makes the total amount of the oral composition 100%. The obtained oral compositions were evaluated as follows, and the results are shown in the table.

[0050] <Evaluation method> [Fluoride ion retention] A 6 x 6 mm square slice of bovine enamel was immersed in a solution prepared by diluting the oral composition 4 times with purified water for 3 minutes and then immediately washed three times with purified water. After drying, the slice was contacted with 120 μL of artificial saliva on its top surface for 3 minutes for extraction. The concentration of extracted fluoride ions was measured using an ion meter (Thermo Fisher Scientific, product name "Orion 1115000 4-Star"), and the average value of three data points was recorded as the fluoride ion retention amount (unit: ppm (by mass)). Fluoride ion retention was evaluated according to the following criteria: (Evaluation criteria) ◎: Fluoride ion retention is 0.3 ppm or more. Good: Fluoride ion retention is 0.2 ppm or more and less than 0.3 ppm. △: Fluoride ion retention amount is 0.1 ppm or more and less than 0.2 ppm. ×: The amount of fluoride ions retained is less than 0.1 ppm.

[0051] [Inhibition of viscous substance formation (opening torque test)] The cap and container body described in Example 1 of Japanese Patent No. 7154003 were used. The oral composition was filled into the container body, and the cap was tightened with a torque of 0.05 MPa. The container was turned upside down with the cap facing downwards and left to stand at 50°C for 30 days. After standing, the opening torque was measured and evaluated according to the following criteria. (Evaluation criteria) ◎: Opening torque is 200cN·m or more and less than 300cN·m. ○: Opening torque is 300cN·m or more and less than 400cN·m. △: Opening torque is 400cN·m or more and less than 500cN·m. ×: Opening torque is 500cN·m or more.

[0052] [Flavor] The evaluation was carried out by a sensory test conducted by 10 expert panelists. The subjects rinsed their mouths with 10 mL of the oral composition for 30 seconds, and the unpleasant taste felt during use was rated according to the following rating scale. The average of the scores of the 10 panelists was calculated, and the flavor (lack of unpleasant taste) was evaluated according to the following rating scale. (Scoring criteria) 4 points: Not unpleasant. 3 points: Slightly unpleasant taste, but not problematic for use. 2 points: Distasteful and problematic in use. 1 point: Strongly unpleasant. (Evaluation criteria) ◎: Average score of 3.5 points or more. ○: Average score is 3.0 or more but less than 3.5 points. △: Average score is between 2.0 and 3.0 points. ×: Average score less than 2.0 points.

[0053] [Table 1]

[0054] [Table 2]

[0055] [Table 3]

[0056] [Table 4]

[0057] As shown in Tables 1 to 4, the oral compositions of Examples 1 to 25 were excellent in fluoride ion retention and also in inhibiting the formation of viscous substances.In addition, they also had a good flavor. On the other hand, Comparative Example 1, which did not contain component (A), Comparative Example 2, which did not contain component (B), and Comparative Example 3, which did not contain component (C), were inferior in fluoride ion retention. Comparative Example 2 also had an inferior flavor. Comparative Example 4, which did not contain component (D), was inferior in its ability to inhibit the formation of viscous substances.

[0058] <Prescription example> In all of the following formulation examples, the fluoride ion retention was excellent, the viscosity-inhibiting properties were also good, and the flavor was also good.

[0059] <Prescription Example 1: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.01% Silica anhydride 10% Sorbitol solution (concentration 70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fatty acid amidopropyl betaine 0.5% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0060] <Prescription Example 2: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.1% Silica anhydride 10% Sorbitol solution (concentration 70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fatty acid amidopropyl betaine 0.5% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0061] <Formulation Example 3: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 1% Silica anhydride 10% Sorbitol solution (concentration 70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fatty acid amidopropyl betaine 0.5% Sodium saccharin 0.2% Fragrance 1% Purified water remainder

[0062] <Prescription Example 4: Oral spray> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.1% Glycerin 3% Propylene glycol 3% Xylitol 2% Polyoxyethylene hydrogenated castor oil (100E.O) 0.2% Methyl parahydroxybenzoate 0.05% Citric acid 0.05% Sodium citrate 0.2% Sodium saccharin 0.01% Fragrance 0.2% Purified water remainder

Claims

1. (A) component: sodium fluoride, (B) component: water-soluble calcium salt, Component (C): at least one selected from the group consisting of condensed phosphoric acid and salts thereof, and An oral composition containing component (D): a zinc ion source.

2. 2. The oral composition according to claim 1, wherein the component (B) comprises one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate.

3. 2. The oral composition according to claim 1, wherein the component (C) comprises at least one selected from the group consisting of sodium tripolyphosphate, pyrophosphate, and alkali metal pyrophosphate.

4. 2. The oral composition according to claim 1, wherein the component (D) comprises one or more selected from the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate, and zinc laurate.

5. 2. The oral composition according to claim 1, wherein (B) / (D), which represents the molar ratio of the component (B) to the component (D), is 0.01 to 300.

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