topical skin preparations

Abstract

The present invention provides an external skin preparation containing cyanocobalamin, which can be applied to a wide range of preparations while preventing fading of the cyanocobalamin. [Solution] The topical skin preparation contains (A) cyanocobalamin and (B) pomegranate fruit extract and / or rose canina fruit extract. By containing component (A) and component (B), the topical skin preparation can be applied to a wide range of formulations while preventing fading of cyanocobalamin. The topical skin preparation may also contain component (A) in an amount of 0.0001 to 2% by mass, based on the total mass of the topical skin preparation, and component (B) in an amount of 0.0001 to 1% by mass, based on the total mass of the topical skin preparation, with the ratio (A / B) of the amount of component (A) to the amount of component (B) being 50 or less.

Description

[Technical Field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] In recent years, cosmetics of various colors have become popular for the purpose of brightening the skin tone and reducing the appearance of dullness. However, these cosmetics are colored using pigments and do not have the effect of brightening the skin itself, and therefore do not provide a fundamental solution. Furthermore, it is predicted that the number of people who are concerned about their facial skin tone and dryness due to irregular lifestyles, poor diet, stress, abnormal weather, polluted outdoor air, etc. is on the rise. Therefore, there is a strong demand for cosmetics that brighten the skin itself while solving skin problems.

[0003] Natural pigments derived from animals, plants, and microorganisms are used as ingredients that affect skin color, and cyanocobalamin is known as one of these natural pigments. Cyanocobalamin is a type of cobalamin called vitamin B12, and is classified as a water-soluble vitamin that is red or pink in color. Patent Document 1 reports that the use of vitamin B12 containing cyanocobalamin in topical skin preparations can improve dullness of the skin and improve skin transparency.

[0004] On the other hand, many natural pigments, including cyanocobalamin, have poor light and heat resistance and tend to fade over time, which reduces their effectiveness on the skin. Therefore, when natural pigments are incorporated into topical skin preparations, measures to ensure quality are necessary. Examples of measures to ensure quality include stabilizing cyanocobalamin by storing it in a plastic container containing a benzotriazole compound, an anti-fading agent (Patent Document 2), and photostabilizing vitamin B12 by incorporating cyclodextrin or its derivatives (Patent Document 3). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2002-234845 [Patent Document 2] Japanese Patent Application Publication No. 2019-065003 [Patent Document 3] Japanese Patent Application Publication No. 4-049239 Summary of the Invention [Problem to be solved by the invention]

[0006] However, because the above-mentioned measures are technologies reported for pharmaceuticals, they cannot be said to be widely applicable to cosmetics, and the containers are limited to plastic, and the inclusion of cyclodextrin imposes restrictions on the feel of the product. For these reasons, there is a need for a product that is not restricted by the container or feel.

[0007] The present invention has been made in consideration of the above circumstances, and aims to provide an external skin preparation containing cyanocobalamin that can be applied to a wide range of formulations while preventing fading of cyanocobalamin. [Means for solving the problem]

[0008] As a result of intensive research conducted by the present inventors to solve the above problems, it was found that the effect of inhibiting the discoloration of cyanocobalamin can be obtained by incorporating pomegranate fruit extract and / or rosea canina fruit extract. By combining it with Rosa canina fruit extract, the present inventors have discovered an external skin preparation that does not impose restrictions on the container or texture, and have completed the present invention.

[0009] The external skin preparation according to the present invention contains (A) cyanocobalamin and (B) pomegranate fruit extract and / or rose canina fruit extract.

[0010] Due to this constitution, the external skin preparation of the present invention can be applied to a wide range of preparations while preventing fading of cyanocobalamin.

[0011] The topical skin preparation according to the present invention may contain component (A) in an amount of 0.0001% to 2% by mass relative to the total mass of the topical skin preparation, component (B) in an amount of 0.0001 to 1% by mass relative to the total mass of the topical skin preparation, and the ratio (A / B) of the amount of component (A) to the amount of component (B) may be 50 or less.

[0012] With this constitution, the external skin preparation according to the present invention can effectively brighten and moisturize the skin while reducing stickiness on the skin. [Effects of the Invention]

[0013] The present invention provides an external skin preparation containing cyanocobalamin that can be applied to a wide range of formulations while preventing fading of the cyanocobalamin. DETAILED DESCRIPTION OF THE INVENTION

[0014] Hereinafter, embodiments of the present invention will be described, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims. Embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, in this specification, unless otherwise specified, "A to B" representing a numerical range means "greater than or equal to A and less than or equal to B."

[0015] The topical skin preparation according to this embodiment contains (A) cyanocobalamin and (B) pomegranate fruit extract and / or rose canina fruit extract.

[0016] <(A) Cyanocobalamin> The component (A) used in the topical skin preparation according to this embodiment is cyanocobalamin. Cyanocobalamin is a type of typical cobalamin known as vitamin B12, and is a physiologically active substance classified as a water-soluble vitamin. Its chemical structure is a cobalt complex with a porphyrin-like corrin ring and nucleotide structure. Because cyanocobalamin is extremely difficult to synthesize, it is currently produced from the culture medium of bacteria such as actinomycetes.

[0017] Cyanocobalamin is available as a commercially available cosmetic ingredient, such as "Vitamin B12 cryst Food Grade" (DSM Co., Ltd.).

[0018] In the topical skin preparation according to this embodiment, cyanocobalamin, which is component (A), contributes to improving skin brightness and transparency through moisture. There are no particular restrictions on the amount of component (A) blended, but it is preferably 0.0001% by mass to 2% by mass relative to the total mass of the topical skin preparation. If the amount of component (A) blended is 0.0001% by mass or more, it is possible to sufficiently brighten the skin and obtain sufficient skin transparency through moisture. On the other hand, if the amount of component (A) blended is 2% by mass or less, stickiness and cyanocobalamin precipitation are suppressed, and skin moisture is improved. From the viewpoint of usability, the amount of component (A) blended is more preferably 0.0002% by mass or more and 1% by mass or more. % by mass or less, and more preferably 0.0005% by mass or more and 0.01% by mass or less.

[0019] <(B) Pomegranate Fruit Extract and / or Rosa Canina Fruit Extract> The component (B) used in the topical skin preparation according to this embodiment is pomegranate fruit extract and / or rose canina fruit extract.

[0020] Pomegranate fruit extract is an extract obtained from pomegranate fruit. Pomegranate fruit extract is available as a commercially available cosmetic ingredient. Examples of commercially available products include "Pomegranate Fruit Extract KB (Ikeda Tohka Kogyo Co., Ltd.)" and "Amiporine ER (Croda Japan Co., Ltd.)."

[0021] Rosa canina fruit extract is an extract obtained from the fruit of Rosa canina (a plant of the Rosaceae family). Rosa canina is a type of wild rose, which is also called rosehip, so Rosa canina is also commonly called rosehip. Methods for extracting Rosa canina fruit extract include, but are not limited to, methods using water, ethanol, butylene glycol, etc.

[0022] Rosa canina fruit extract is available as a cosmetic ingredient in various commercial products, including "Falcorex Nobara B" and "Ecofarm Nobara B" (both from Ichimaru Pharcos Co., Ltd.), "Nobara Extract" (Koei Kogyo Co., Ltd.), and "Rosehip Extract BG100" (Maruzen Pharmaceutical Co., Ltd.).

[0023] The inclusion of pomegranate fruit extract and / or rose canina fruit extract as component (B) in the topical skin preparation of this embodiment can inhibit fading of cyanocobalamin. This is presumably because the polyphenols contained in pomegranate fruit extract and / or rose canina fruit extract absorb light and heat, thereby inhibiting the effects of light and heat on cyanocobalamin.

[0024] The amount of component (B) contained in the topical skin preparation according to this embodiment is not particularly limited, but is preferably 0.0001% to 1% by mass relative to the total mass of the topical skin preparation. A content of component (B) of 0.0001% by mass or more provides sufficient anti-fading effect of cyanocobalamin, while a content of component (B) of 1% by mass or less suppresses stickiness and inhibits the unpleasant odor and discoloration of the topical skin preparation over time that are derived from pomegranate fruit extract and / or rose hip extract. From the viewpoint of usability, the content of component (B) is more preferably 0.0005% to 1% by mass, and even more preferably 0.001% to 1% by mass.

[0025] Pomegranate fruit extract and / or rosehip extract can be used alone to improve skin elasticity, but adding ingredient (A) synergistically enhances the skin elasticity-enhancing effect and provides excellent lasting effects.

[0026] Furthermore, in the topical skin preparation according to this embodiment, the ratio (A / B) of the amount of component (A) to the amount of component (B) is preferably not more than 50, more preferably not more than 20, and even more preferably not more than 10. When this ratio is not more than 50, the effect of component (B) in inhibiting discoloration relative to component (A) can be fully exerted, and the effect of moisturizing the skin over time can be maintained.

[0027] The topical skin preparation according to this embodiment contains pomegranate fruit extract and / or rose canina fruit extract as component (B), which inhibits the discoloration of cyanocobalamin as component (A). Furthermore, the inclusion of pomegranate fruit extract and / or rose canina fruit extract in the topical skin preparation does not alter the feel of the topical skin preparation. Therefore, it is recommended to use a plastic container with anti-fading properties or an anti-fading agent that may alter the feel of the topical skin preparation. Therefore, there are no restrictions on the container or feel, and the topical skin preparation according to this embodiment can be applied to a wide range of preparations.

[0028] <Other ingredients> In addition to the above-mentioned components, the topical skin preparation according to this embodiment may contain other components, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, polymeric compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, and the like, as appropriate, provided that the purpose of the present invention is not impaired.

[0029] Furthermore, the topical skin preparation of the present invention can be appropriately blended with physiologically active ingredients within the scope of the present invention. Physiologically active substances are substances that impart some physiological activity to the skin when applied to the skin, and examples thereof include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation soothing agents, analgesics, and cell activators.

[0030] The topical skin preparation according to this embodiment can be produced by a conventional method. The topical skin preparation according to this embodiment can be used, for example, as a lotion, emulsion, cream, gel, serum, sheet mask, makeup, body lotion, body gel, body cream, facial soap, facial cleanser, body soap, cleansing agent, makeup base, etc. The dosage form can also be selected arbitrarily depending on the purpose. Examples include liquid, cream, gel, emulsion, sheet, stick, and aerosol forms. The topical skin preparation according to this embodiment is not limited to general topical preparations, but also includes quasi-drugs, designated quasi-drugs, and topical pharmaceuticals. [Example]

[0031] The present invention will now be described in detail with reference to examples, but is not limited thereto. Prior to the examples, the test and evaluation methods employed in each example will be described.

[0032] 1. Skin brightness evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. An appropriate amount of each skin preparation from the Examples and Comparative Examples was then applied, and a sensory evaluation of the skin brightness after use was conducted using the following scoring system. The evaluation criteria were based on the average of the scores for brightness from the 10 panelists, and the results were classified as follows: <Brightness rating and details> 5 points: Skin feels noticeably brighter after use. 4 points: Skin feels slightly brighter after use. 3 points: I feel like my skin is slightly brighter after using it. 2 points: My skin feels slightly brighter after use. 1 point: My skin doesn't feel brighter after using it. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0033] 2. Skin moisture evaluation test The 10 evaluation panel members washed their forearms with lukewarm water, then placed them in a bath at 25°C, The skin was allowed to acclimate for 20 minutes in an environment with a relative humidity of 50%. After that, an appropriate amount of each of the skin preparations of the Examples and Comparative Examples was applied, and the moist feeling of the skin after use was evaluated using the following rating system. The evaluation criteria were based on the average value of the total moist feeling ratings of 10 panelists, and were classified as follows: <Brightness rating and details> 5 points: Skin feels very moisturized after use. 4 points: Skin feels slightly moisturized after use. 3 points: My skin feels slightly moisturized after use. 2 points: After use, the skin feels slightly moisturized. 1 point: My skin doesn't feel moisturized at all after use. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0034] 3. Skin elasticity evaluation test The cheeks of 10 expert panel members were washed with soap, and then conditioned for 20 minutes in an environment of 25°C and 50% relative humidity. After that, 0.1 mL / cm of the topical skin preparations according to the examples and comparative examples of the present invention were applied to the cheeks. 2 After application, the skin was allowed to acclimate for 60 minutes in an environment of 25°C and 50% relative humidity, and then the skin's viscoelasticity was measured using a Cutometer (MPA580, manufactured by Courage+Khazaka). The skin elasticity improvement effect was evaluated by calculating the elasticity change rate (%) using the following formula, obtaining the average value for 10 subjects, and based on the following criteria. The results are shown in the table. <Calculation formula> Elasticity change rate (%) = (skin elasticity 60 minutes after application / skin elasticity before application) x 100 (Skin elasticity evaluation criteria) ◎: Elasticity change rate (%) was 150% or more. ○: The elasticity change rate (%) was 120% or more and less than 150%. △: Elasticity change rate (%) was 100% or more and less than 120%. ×: The elasticity change rate (%) was less than 100%.

[0035] 4. Evaluation test of color difference change in the appearance of topical skin preparations over time The topical skin preparations of the examples and comparative examples of the present invention were measured using a colorimeter (ZE 6000, manufactured by Nippon Denshoku Industries Co., Ltd.) and the a* values ​​were quantified. The a* values ​​were quantified for the products immediately after production and for the products stored at 50°C for one month, and the color difference change Δa* was calculated using the following formula. <Calculation formula> Δa*=((a* value of the topical skin preparations of Examples and Comparative Examples immediately after production)−(a* value of the topical skin preparations of Examples and Comparative Examples stored at 50°C for 1 month) / a* value of the topical skin preparations of Examples and Comparative Examples immediately after production)×100 (Evaluation criteria for color difference change) ⊚: The change in color difference was less than 20. ◯: The amount of change in color difference was 20 or more and less than 30. △: The amount of change in color difference was 30 or more and less than 50. ×: The change in color difference was 50 or more.

[0036] 5. Non-stickiness evaluation test After washing the forearms of 10 expert panelists with lukewarm water, the samples were allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. An appropriate amount of the agent was applied, and a sensory evaluation was conducted on the stickiness of the skin during and after use using the following rating system. The evaluation criteria were the average of the scores given by 10 people regarding the lack of stickiness, and were classified as follows: <Scores and details regarding non-stickiness> 5 points: Skin does not feel sticky during or after use. 4 points: Skin feels slightly sticky during and after use. 3 points: Skin feels slightly sticky during and after use. 2 points: Skin feels sticky during and after use. 1 point: The skin feels very sticky during and after use, which is uncomfortable. (Evaluation criteria for non-stickiness) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0037] <Examples 1 to 12 and Comparative Examples 1 to 3> The topical skin preparations having the formulations of Examples 1 to 12 and Comparative Examples 1 to 3 shown in Tables 1 and 2 were prepared by conventional methods and evaluated by the respective test methods.

[0038] [Table 1]

[0039] [Table 2]

[0040] As is clear from Tables 1 and 2, the topical skin preparations of Examples 1 to 12 all had excellent performance. On the other hand, Comparative Examples 1 to 3 were inferior in any of the following aspects: skin brightness, skin moisture, rate of change in skin elasticity, amount of change in color difference in appearance over time, non-stickiness, and stability, and therefore failed to achieve the object of the present invention.

[0041] Other examples of the topical skin preparation of the present invention are listed below as formulation examples. The topical skin preparations of these formulation examples were also examined for the above-mentioned skin transparency, changes in skin transparency evaluation over time, skin moisture, changes in appearance color difference over time, non-stickiness, and stability, and were found to have excellent properties in all respects.

[0042] Example 13 (lotion) (mass%) (1) Tranexamic acid 1.0% (2) Dipotassium glycyrrhizinate 0.1% (3) α-glucan oligosaccharide 0.1% (4) Glycosyltrehalose 0.5% (5) Niacinamide 3.5% (6) Tocopherol acetate 0.001% (7) Dipropylene glycol 2.5% (8) Glycerin 1.0% (9) 1,3-butylene glycol 7.0% (10) Propanediol 2.0% (11) Citric acid 0.05% (12) Potassium hydroxide 0.005% (13) Polyoxyethylene hydrogenated castor oil 0.6% (14) Polyoxyethylene monolaurate Sorbitan (20E.O.) 0.1% (15) Edetate disodium 0.005% (16) Sodium pyrosulfite 0.001% (17) Polyglycerin-6 0.3% (18) Methylgluceth-20 0.2% (19) Tripropylene glycol 4.0% (20) Cyclohexylglycerin 0.2% (21) Phenoxyethanol 0.2% (22) Methylparaben 0.05% (23) Cyanocobalamin 0.005% (24) Pomegranate Fruit Extract 0.01% (25) Rosa canina fruit extract 0.01% (26) Yuzu Fruit Extract 0.25% (27) Peony Root Extract 0.05% (28) Saccharomyces / Rice Fermentation Liquid 0.25% (29) Purified water remainder

[0043] (Production method) (1) to (5), (8) to (12), and (15) to (28) were added to (29) and dispersed with a propeller until uniformly dissolved (Liquid A). (6), (13), and (14) were dissolved in (7), and then added to Liquid A and uniformly dissolved to prepare a lotion.

[0044] Example 14 (sheet mask) (mass%) (1) Cyanocobalamin 0.001% (2) Pomegranate Fruit Extract 0.01% (3) Glucosyltrehalose 1.0% (4) Glycine 0.5% (5) Alaria Esculenta Extract 0.1% (6) Rose water 0.4% (7) Ascorbic acid 2-glucoside 0.001% (8) Sage leaf extract 0.006% (9) Polyethylene glycol (average molecular weight 1000) 0.5% (10) Sodium polyacrylate 1.5% (11) Dipropylene glycol 10.0% (12) Nicotinamide 0.01% (13) Alkyl-modified carboxyvinyl polymer 0.15% (14) PEG-10 glyceryl triisostearate 0.1% (15) (PCA / Isostearic acid) PEG-40 Hydrogenated Castor Oil 0.1% (16) PEG-60 hydrogenated castor oil 0.1% (17) Monopotassium phosphate 0.09% (18) Disodium phosphate 0.01% (19) Methylparaben 0.005% (20) Cyclohexylglycerin 0.5% (21) Squalane 0.1% (22) PEG-11 methyl ether dimethicone 0.05% (23) Ethylhexyl palmitate 0.1% (24) Purified water remainder

[0045] (Production method) (1) to (20) and (24) were heated to 80°C and stirred to dissolve uniformly (Liquid A). (21) to (23) were heated to 80°C and stirred to disperse uniformly (Liquid B). Liquid B was added to Liquid A and dispersed uniformly using a homomixer, and then cooled to 30°C to prepare a beauty serum. The prepared beauty serum was then impregnated into a nonwoven fabric sheet to prepare a sheet mask.

[0046] Example 15 (cream) (mass%) (1) Cyanocobalamin 0.01% (2) Rosa canina fruit extract 0.1% (3) Saccharomyces / rice fermentation liquid 1.0% (4) Lactobacillus / lotus seed fermented liquid 1.0% (5) Glucosylceramide 0.001% (6) α-glucan 0.006% (7) Glycerin 5.0% (8) 1,3-butylene glycol 4.5% (9) Agar 1.0% (10) Sodium acrylate grafted starch 0.5% (11) Dipropylene glycol 6.0% (12) Hydrogenated lecithin 0.5% (13) Cholesterol 0.1% (14) Pentaerythrityl tetraethylhexanoate 2.0% (15) Dimer Dilinoleic Acid (Phytosteryl / Isostearyl / Cetyl / Stearyl / Behenyl) 0.5% (16) Disodium edetate 0.01% (17) Methylparaben 0.05% (18)Fragrance 0.01% (19) Purified water remainder

[0047] (Production method) (20) to (35) and a portion of (50) were heated to approximately 80°C and stirred to dissolve uniformly (liquid A). (36) to (49) were heated to approximately 80°C and stirred to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed using a homomixer. The mixture was then cooled, and a solution of (1) to (19) in the remainder of (50) at 40°C was added and further dissolved uniformly. The mixture was again cooled to 30°C to prepare a whitening makeup base cream.

[0048] Example 16 (all-in-one gel) (mass%) (1) Cyanocobalamin 0.005% (2) Pomegranate Fruit Extract 0.005% (3) α-glucan oligosaccharide 0.1% (4) Glycosyltrehalose 1.0% (5) Dimethicone 2.0% (6) Diphenylsiloxyphenyl trimethicone 1.0% (7) PEG-11 methyl ether dimethicone 0.3% (8) PEG-60 hydrogenated castor oil 0.5% (9) Pentaerythrityl tetraethylhexanoate 0.2% (10) Squalane 0.2% (11) Ceramide III 0.0001% (12) Carboxyvinyl polymer 0.3% (13) Xanthan gum 0.0001% (14) (Acrylates / Alkyl acrylate) (C10-30) copolymer 0.05% (15) Silk extract 0.01% (16) Sodium Hyaluronate 0.001% (17) Soybean extract 0.01% (18) Rice bran extract 0.01% (19) Hydrolyzed conchiolin 0.01% (20) PEG-75 0.5% (21) Hydrolyzed Collagen 0.001% (22) Ascorbic acid sulfate disodium 0.05% (23) Sodium chondroitin sulfate 0.001% (24) Heparinoid 0.1% (25) Trisodium Hydroxyethylethylenediaminetriacetate 0.1% (26) Phenoxyethanol 0.6% (27) Methylparaben 0.1% (28) Purified water remainder

[0049] (Production method) (5) to (11) were heated to 70°C and uniformly dissolved (Liquid A). (12) to (27) were added to a portion of (28), heated to 70°C, and uniformly dissolved (Liquid B). Liquid B was added to Liquid A, and the mixture was dispersed using a homomixer until uniform, followed by cooling to 35°C (Liquid C). (1) to (4) were dissolved in the remainder of (28), and then added to Liquid C and uniformly dissolved to prepare an all-in-one gel.

[0050] Example 17 (Cosmetic Serum) (mass%) (1) Cyanocobalamin 0.005% (2) 1,3-butylene glycol 6.0% (3) Ethanol 5.0% (4) Dipropylene glycol 5.0% (5) Polyoxyethylene hydrogenated castor oil 0.5% (6) Potassium hydroxide 0.01% (7) Disodium edetate 0.005% (8) Phenoxyethanol 0.6% (9) Methylparaben 0.1% (10) Carboxyvinyl polymer 0.01% (11) Xanthan gum 0.1% (12) Pomegranate Fruit Extract 0.1% (13) Rosa canina fruit extract 0.5% (14) Rose flower extract 0.5% (15) Kiwi extract 0.5% (16) Peony Root Extract 0.5% (17) Soybean extract 0.5% (18) Polygonum Cuspidatum Root Extract 0.5% (19) Pomegranate flower extract 0.5% (20) Royal jelly extract 1.0% (21) Centella asiatica extract 1.0% (22) Ceramide II 0.001% (23) Sodium Hyaluronate 0.01% (24) Hydrolyzed Collagen 0.01% (25) Purified water remainder

[0051] (Production method) (1) to (24) were added to (25), heated to 70°C, and dispersed in a homomixer until uniform to prepare a cosmetic liquid.

[0052] Example 18 (whitening makeup base cream) (mass%) (1) Cyanocobalamin 0.05% (2) Nicotinamide 0.9% (3) Pomegranate Fruit Extract 0.01% (4) Rosa canina fruit extract 0.01% (5) Glycine 8.0% (6) Scutellaria root extract 0.75% (7) D-Pantothenyl alcohol 0.05% (8) Chamomile flower extract 0.0003% (9) Gardenia fruit extract 2.5% (10) Licorice Root Extract 5.0% (11) Althea Root Extract 0.0007% (12) Aloe Vera Juice 0.85% (13) Fennel Fruit Extract 1.0% (14) Turmeric extract 0.02% (15) Coenzyme Q10 0.001% (16) Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.75% (17) Dipotassium glycyrrhizinate 0.2% (18) Ascorbic acid 2-glucoside 2.0% (19) Tranexamic acid 3.0% (20) Sodium N-stearoyl-L-glutamate 0.5% (21) Sorbitan monoisostearate 0.1% (22) PEG-10 glyceryl triisostearate 0.2% (23) PEG-60 hydrogenated castor oil 0.9% (24) Carboxyvinyl polymer 0.1% (25) Xanthan gum 0.01% (26) Hydrophobized hydroxypropyl methylcellulose 0.01% (27) Potassium hydroxide 0.02% (28) L-Arginine 0.01% (29) Citric acid 0.01% (30) Dipotassium phosphate 0.04% (31)Tartaric acid 0.01% (32) Triethanolamine 0.02% (33) Ethylparaben 0.05% (34) Methylparaben 0.05% (35) Phenoxyethanol 0.5% (36) 3-O-Ethyl ascorbic acid 0.01% (37) Retinol palmitate 0.001% (38) dl-α-Tocopherol Nicotinate 0.05% (39) Mineral oil 7.0% (40) Octyldodecyl myristate 2.0% (41) Squalane 1.0% (42) Tri(caprylic / capric / myristic / stearic acid) Glyceryl Glyceryl 0.5% (43) Zinc oxide 0.1% (44) Di(phytosteryl / isostearyl / ) dilinoleate Cetyl / Stearyl / Behenyl) 0.3% (45) White Beeswax 1.2% (46) Sodium cetyl sulfate 0.5% (47) Phenyl trimethicone 0.3% (48) Methylphenylpolysiloxane 1.0% (49) Diphenyl trimethicone 0.1% (50) Purified water remainder

[0053] (Production method) (20) to (35) and a portion of (50) were heated to approximately 80°C and stirred to dissolve uniformly (liquid A). (36) to (49) were heated to approximately 80°C and stirred to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed using a homomixer. The mixture was then cooled, and a solution of (1) to (19) in the remainder of (50) at 40°C was added and further dissolved uniformly. The mixture was again cooled to 30°C to prepare a whitening makeup base cream.

Claims

1. A topical skin preparation containing the following components (A) and (B): (A) Cyanocobalamin (B) Pomegranate Fruit Extract and / or Rosa Canina Fruit Extract

2. The amount of component (A) is 0.0001 to 2% by mass relative to the total mass of the topical skin preparation, The amount of component (B) is 0.0001 to 1% by mass relative to the total mass of the topical skin preparation, 2. The external skin preparation according to claim 1, wherein the ratio (A / B) of the amount of component (A) to the amount of component (B) is 50 or less.

Images