topical skin preparations

Abstract

To provide an external skin preparation containing cyanocobalamin, which gives brightness to the skin, has excellent moisturizing power and has a pore care effect. [Solution] The topical skin preparation contains (A) cyanocobalamin and (B) retinol palmitate. By containing component (A) and component (B), the topical skin preparation brightens the skin, has excellent moisturizing properties, and provides pore care effects. The topical skin preparation may also contain component (A) in an amount of 0.0001 to 2% by mass relative to the total mass of the topical skin preparation, component (B) in an amount of 0.000001 to 1% by mass relative to the total mass of the topical skin preparation, and the ratio of component (A) to component (B) (A / B) may be 200 or less.

Description

[Technical Field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] In recent years, cosmetics of various colors have become popular for the purpose of brightening the skin tone and reducing the appearance of dullness. However, these cosmetics are colored using pigments and do not have the effect of brightening the skin itself, and therefore do not provide a fundamental solution. Furthermore, it is predicted that the number of people who are concerned about their facial skin tone and dryness due to irregular lifestyles, poor diet, stress, abnormal weather, polluted outdoor air, etc. is on the rise. Therefore, there is a strong demand for cosmetics that brighten the skin itself while solving skin problems.

[0003] Natural pigments derived from animals, plants, and microorganisms are used as ingredients that affect skin color, and cyanocobalamin is known as one of these natural pigments. Cyanocobalamin is a type of cobalamin called vitamin B12, and is classified as a water-soluble vitamin that is red or pink in color. Patent Document 1 reports that the use of vitamin B12 containing cyanocobalamin in topical skin preparations can improve dullness of the skin and improve skin transparency.

[0004] However, topical skin preparations containing cyanocobalamin are not satisfactory in terms of moisturizing power, which is generally required for cosmetics, and therefore, topical skin preparations containing cyanocobalamin that have sufficient moisturizing power are desired. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2002-234845 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention has been made in view of the above circumstances, and aims to provide an external skin preparation containing cyanocobalamin that brightens the skin, has excellent moisturizing power, and has a pore care effect. [Means for solving the problem]

[0007] As a result of intensive research conducted by the inventors to solve the above problems, they discovered that by incorporating retinol palmitate, synergistic effects such as improved skin moisturizing ability, improved elasticity, and pore care effects can be obtained while maintaining the effects of cyanocobalamin, and thus completed the present invention.

[0008] The external skin preparation according to the present invention contains (A) cyanocobalamin and (B) retinol palmitate.

[0009] With this constitution, the external skin preparation according to the present invention brightens the skin, has excellent moisturizing power, and has a pore care effect.

[0010] The amount of component (A) in the topical skin preparation according to the present invention may be 0.0001% to 2% by mass, based on the total mass of the topical skin preparation, and the amount of component (B) in the topical skin preparation may be 0.000001 to 1% by mass, based on the total mass of the topical skin preparation.

[0011] With such a constitution, the external skin preparation according to the present invention can further improve the moisturizing power and pore care effect while providing more brightness to the skin.

[0012] In the external skin preparation according to the present invention, the ratio (A / B) of the amount of component (A) to the amount of component (B) may be 200 or less.

[0013] The external skin preparation according to the present invention, having such a constitution, can suppress stickiness of the skin when used. [Effects of the Invention]

[0014] According to the present invention, it is possible to provide an external skin preparation containing cyanocobalamin that brightens the skin, has excellent moisturizing power, and has a pore care effect. DETAILED DESCRIPTION OF THE INVENTION

[0015] Hereinafter, embodiments of the present invention will be described, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims. Embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, in this specification, unless otherwise specified, "A to B" representing a numerical range means "greater than or equal to A and less than or equal to B."

[0016] The topical skin preparation according to this embodiment contains (A) cyanocobalamin and (B) retinol palmitate.

[0017] <(A) Cyanocobalamin> The component (A) used in the topical skin preparation according to this embodiment is cyanocobalamin. Cyanocobalamin is a type of typical cobalamin known as vitamin B12, and is a physiologically active substance classified as a water-soluble vitamin. Its chemical structure is a cobalt complex with a porphyrin-like corrin ring and nucleotide structure. Because cyanocobalamin is extremely difficult to synthesize, it is currently produced from the culture medium of bacteria such as actinomycetes.

[0018] Cyanocobalamin is available as a commercially available cosmetic ingredient, such as "Vitamin B12 cryst Food Grade" (DSM Co., Ltd.).

[0019] In the topical skin preparation according to this embodiment, cyanocobalamin, which is component (A), contributes to improving skin brightness and transparency through moisture. The amount of component (A) is not particularly limited, but is preferably 0.0001% to 2% by mass relative to the total mass of the topical skin preparation. A content of component (A) of 0.0001% by mass or more can sufficiently brighten the skin and provide sufficient moisture-induced transparency. On the other hand, a content of component (A) of 2% by mass or less can suppress stickiness and cyanocobalamin precipitation, resulting in good skin moisture. From the viewpoint of usability, the amount of component (A) is more preferably 0.0002% to 1% by mass, and even more preferably 0.0005% to 0.01% by mass.

[0020] <(B) Retinol Palmitate> The component (B) used in the topical skin preparation according to this embodiment is retinol palmitate. Retinol palmitate is a vitamin A derivative whose stability has been increased by esterifying the hydroxyl group of retinol with palmitic acid. It is usually incorporated into foods as a vitamin A fortifier, vitamin preparations for the prevention and treatment of skin keratosis, etc., and topical skin preparations as an effective ingredient for preventing and recovering skin aging. Retinol palmitate also has the effect of reducing the appearance of pores. Furthermore, when retinol palmitate is included in a topical skin preparation together with the above-mentioned cyanocobalamin, it synergistically improves the skin's moisturizing power, elasticity, and pore care effects of the topical skin preparation, and these effects are maintained for a long period of time.

[0021] Retinol palmitate is available as a commercially available cosmetic ingredient. Examples of commercially available products include "Vitamin A-Palmitate Care 1.7TOC" (BASF Japan Ltd.), "Vitamin A Oil" (DSM K.K.), and "Riken A Palmitate 1000" (Riken Vitamin Co., Ltd.).

[0022] The amount of component (B) contained in the topical skin preparation according to this embodiment is preferably 0.000001% by mass or more and 1% by mass or less. From the viewpoint of usability, the amount of component (B) is more preferably 0.000001% by mass to 0.1% by mass, and even more preferably 0.00001% by mass to 0.01% by mass. When the amount of component (B) is 0.000001% by mass or more, a sufficient moisturizing effect can be obtained, and when it is 1% by mass or less, stickiness and irritation to the skin can be suppressed.

[0023] Furthermore, in the topical skin preparation of this embodiment, the ratio (A / B) of the amount of component (A) to the amount of component (B) is preferably 200 or less, more preferably 100 or less, and even more preferably 50 or less, from the viewpoint of suppressing stickiness of the skin when the topical skin preparation is used.

[0024] The topical skin preparation of this embodiment contains component (A) cyanocobalamin and component (B) retinol palmitate, which provides skin brightness while providing excellent moisturizing properties and pore care effects.

[0025] <Other ingredients> In addition to the above-mentioned components, the topical skin preparation according to this embodiment may contain other components, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, polymeric compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, and the like, as appropriate, provided that the purpose of the present invention is not impaired.

[0026] Furthermore, the topical skin preparation of the present invention can be appropriately blended with physiologically active ingredients within the scope of the present invention. Physiologically active substances are substances that impart some physiological activity to the skin when applied to the skin, and examples thereof include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation soothing agents, analgesics, and cell activators.

[0027] The topical skin preparation according to this embodiment can be produced by a conventional method. The topical skin preparation according to this embodiment can be used, for example, as a lotion, emulsion, cream, gel, serum, sheet mask, makeup, body lotion, body gel, body cream, facial soap, facial cleanser, body soap, cleansing agent, makeup base, etc. The dosage form can also be selected arbitrarily depending on the purpose. Examples include liquid, cream, gel, emulsion, sheet, stick, and aerosol forms. The topical skin preparation according to this embodiment is not limited to general topical preparations, but also includes quasi-drugs, designated quasi-drugs, and topical pharmaceuticals. [Example]

[0028] The present invention will now be described in detail based on examples, but is not limited thereto. Before going into the examples, the test methods and evaluation methods used in each example will be explained.

[0029] 1. Skin brightness evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. An appropriate amount of each skin preparation from the Examples and Comparative Examples was then applied, and a sensory evaluation of the skin brightness after use was conducted using the following scoring system. The evaluation criteria were based on the average of the scores for brightness from the 10 panelists, and the results were classified as follows: <Brightness rating and details> 5 points: Skin feels noticeably brighter after use. 4 points: Skin feels slightly brighter after use. 3 points: I feel like my skin is slightly brighter after using it. 2 points: My skin feels slightly brighter after use. 1 point: My skin doesn't feel brighter after using it. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0030] 2. Skin moisture evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. After that, an appropriate amount of the topical skin preparations of the Examples and Comparative Examples was applied, and a sensory evaluation was conducted on the moisturizing feeling of the skin after use using the following scoring system. The evaluation criteria were classified as follows using the average value of the total scores for the moisturizing feeling of the 10 panelists. <Brightness rating and details> 5 points: Skin feels very moisturized after use. 4 points: Skin feels slightly moisturized after use. 3 points: My skin feels slightly moisturized after use. 2 points: After use, the skin feels slightly moisturized. 1 point: My skin doesn't feel moisturized at all after use. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0031] 3. Skin elasticity evaluation test The cheeks of 10 expert panel members were washed with soap, and then conditioned for 20 minutes in an environment of 25°C and 50% relative humidity. After that, 0.1 mL / cm of the topical skin preparations according to the examples and comparative examples of the present invention were applied to the cheeks. 2 After application, the skin was allowed to acclimate for 60 minutes in an environment of 25°C and 50% relative humidity, and then the skin's viscoelasticity was measured using a Cutometer (MPA580, manufactured by Courage+Khazaka). The skin elasticity improvement effect was evaluated by calculating the elasticity change rate (%) using the following formula, obtaining the average value for 10 subjects, and based on the following criteria. The results are shown in the table. <Calculation formula> Elasticity change rate (%) = (skin elasticity 60 minutes after application / skin elasticity before application) x 100 (Skin elasticity evaluation criteria) ◎: Elasticity change rate (%) was 150% or more. ○: The elasticity change rate (%) was 120% or more and less than 150%. △: Elasticity change rate (%) was 100% or more and less than 120%. ×: The elasticity change rate (%) was less than 100%.

[0032] 4. Pore care effect evaluation test Three volunteers were given a cheek wash with soap, and then allowed to acclimate for 20 minutes under an environment of 25°C and 50% relative humidity. Then, the skin surface morphology was measured using a skin image analyzer VISIA (Canfield Scientific). Then, 1.0 ml of the skin preparation of the example or comparative example was applied to half of the face, and after 10 minutes of rest, the skin surface morphology was measured again. The evaluation was classified into the following points based on the average reduction in the number of "prominent pores" of the three volunteers before and after application. (Evaluation criteria for pore care effect) ◎: The average number of pores reduced by 20 or more for the three subjects. ○: The average number of pores decreased by 3 people was between -5 and 20. ×: The average number of pores decreased by less than -5 for the three subjects.

[0033] 5. Non-stickiness evaluation test Ten expert panelists washed their forearms with lukewarm water and then allowed them to acclimate for 20 minutes in an environment at 25°C and 50% relative humidity. Then, an appropriate amount of each skin preparation from the Examples and Comparative Examples was applied, and a sensory evaluation was conducted on the stickiness of the skin during and after use using the following scoring system. The evaluation criteria were based on the average of the scores of the 10 panelists regarding the lack of stickiness, and the results were classified as follows: <Scores and details regarding non-stickiness> 5 points: Skin does not feel sticky during or after use. 4 points: Skin feels slightly sticky during and after use. 3 points: Skin feels slightly sticky during and after use. 2 points: Skin feels sticky during and after use. 1 point: The skin feels very sticky during and after use, which is uncomfortable. (Evaluation criteria for non-stickiness) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0034] <Examples 1 to 14 and Comparative Examples 1 to 3> The topical skin preparations having the formulations of Examples 1 to 11 and Comparative Examples 1 and 2 shown in Tables 1 and 2 were prepared by conventional methods and evaluated by the respective test methods.

[0035] [Table 1]

[0036] [Table 2]

[0037] As is clear from Tables 1 and 2, the topical skin preparations of Examples 1 to 11 had excellent performance in terms of skin brightness, skin moisturizing feeling, changes in skin elasticity, and pore care effects. On the other hand, Comparative Examples 1 and 2 were inferior in terms of skin brightness and pore care effects, and the object of the present invention could not be achieved.

[0038] Other examples of the topical skin preparation of the present invention are listed below as formulation examples. The topical skin preparations of these formulation examples were also examined for the above-mentioned skin brightness, skin moisturizing feeling, skin elasticity change rate, and pore care effect, and were found to have excellent properties in all areas.

[0039] Example 12 (lotion) (mass%) (1) Tranexamic acid 1.0% (2) Dipotassium glycyrrhizinate 0.1% (3) α-glucan oligosaccharide 0.1% (4) Glycosyltrehalose 0.5% (5) Niacinamide 3.5% (6) Retinol palmitate 0.01% (7) Dipropylene glycol 2.5% (8) Glycerin 1.0% (9) 1,3-butylene glycol 7.0% (10) Propanediol 2.0% (11) Citric acid 0.05% (12) Potassium hydroxide 0.005% (13) Polyoxyethylene hydrogenated castor oil 0.6% (14) Polyoxyethylene monolaurate Sorbitan (20E.O.) 0.1% (15) Edetate disodium 0.005% (16) Sodium pyrosulfite 0.001% (17) Polyglycerin-6 0.3% (18) Methylgluceth-20 0.2% (19) Tripropylene glycol 4.0% (20) Cyclohexylglycerin 0.2% (21) Phenoxyethanol 0.2% (22) Methylparaben 0.05% (23) Cyanocobalamin 0.005% (24) Lemon Fruit Extract 0.01% (25) Silk extract 0.01% (26) Yuzu Fruit Extract 0.25% (27) Peony Root Extract 0.05% (28) Saccharomyces / Rice Fermentation Liquid 0.25% (29) Purified water remainder

[0040] (Production method) (1) to (5), (8) to (12), and (15) to (28) were added to (29) and dispersed with a propeller until uniformly dissolved (Liquid A). (6), (13), and (14) were dissolved in (7), and then added to Liquid A and uniformly dissolved to prepare a lotion.

[0041] Example 13 (sheet mask) (mass%) (1) Cyanocobalamin 0.001% (2) Glutathione 0.01% (3) Glucosyltrehalose 1.0% (4) Glycine 0.5% (5) Alaria Esculenta Extract 0.1% (6) Rose water 0.4% (7) Ascorbic acid 2-glucoside 0.001% (8) Sage leaf extract 0.006% (9) Polyethylene glycol (average molecular weight 1000) 0.5% (10) Sodium polyacrylate 1.5% (11) Dipropylene glycol 10.0% (12) Nicotinamide 0.01% (13) Alkyl-modified carboxyvinyl polymer 0.15% (14) PEG-10 glyceryl triisostearate 0.1% (15) (PCA / Isostearic acid) PEG-40 Hydrogenated Castor Oil 0.1% (16) PEG-60 hydrogenated castor oil 0.1% (17) Monopotassium phosphate 0.09% (18) Disodium phosphate 0.01% (19) Methylparaben 0.005% (20) Cyclohexylglycerin 0.5% (21) Retinol palmitate 0.00025% (22) PEG-11 methyl ether dimethicone 0.05% (23) Ethylhexyl palmitate 0.1% (24) Purified water remainder

[0042] (Production method) (1) to (20) and (24) were heated to 80°C and stirred to dissolve uniformly (Liquid A). (21) to (23) were heated to 80°C and stirred to disperse uniformly (Liquid B). Liquid B was added to Liquid A and dispersed uniformly using a homomixer, and then cooled to 30°C to prepare a beauty serum. The prepared beauty serum was then impregnated into a nonwoven fabric sheet to prepare a sheet mask.

[0043] Example 14 (cream) (mass%) (1) Cyanocobalamin 0.01% (2) Sodium hyaluronate 0.1% (3) Saccharomyces / rice fermentation liquid 1.0% (4) Lactobacillus / lotus seed fermented liquid 1.0% (5) Glucosylceramide 0.001% (6) α-glucan 0.006% (7) Glycerin 5.0% (8) 1,3-butylene glycol 4.5% (9) Agar 1.0% (10) Sodium acrylate grafted starch 0.5% (11) Dipropylene glycol 6.0% (12) Hydrogenated lecithin 0.5% (13) Cholesterol 0.1% (14) Pentaerythrityl tetraethylhexanoate 2.0% (15) Retinol palmitate 0.02% (16) Disodium edetate 0.01% (17) Methylparaben 0.05% (18)Fragrance 0.01% (19) Purified water remainder

[0044] (Production method) (1) to (10), (16) to (17) were stirred and added to (19), which was then heated to 70°C and uniformly dissolved (liquid A). (11) to (15) were heated to 70°C and uniformly dissolved (liquid B). Liquid A was added to liquid B, and the mixture was dispersed in a homomixer until uniform, followed by cooling to 30°C. Then, (18) was added and the mixture was further dispersed in a homomixer until uniform, and the mixture was then filled into a container to prepare a cream.

[0045] Example 15 (all-in-one gel) (mass%) (1) Cyanocobalamin 0.005% (2) Rice fermentation liquid 0.1% (3) α-glucan oligosaccharide 0.1% (4) Glycosyltrehalose 1.0% (5) Dimethicone 2.0% (6) Diphenylsiloxyphenyl trimethicone 1.0% (7) PEG-11 methyl ether dimethicone 0.3% (8) PEG-60 hydrogenated castor oil 0.5% (9) Pentaerythrityl tetraethylhexanoate 0.2% (10) Squalane 0.2% (11) Retinol palmitate 0.01% (12) Carboxyvinyl polymer 0.3% (13) Xanthan gum 0.0001% (14) (Acrylates / Alkyl Acrylates) (C10-30) copolymer 0.05% (15) Silk extract 0.01% (16) Sodium Hyaluronate 0.001% (17) Soybean extract 0.01% (18) Rice bran extract 0.01% (19) Hydrolyzed conchiolin 0.01% (20) PEG-75 0.5% (21) Hydrolyzed Collagen 0.001% (22) Ascorbic acid sulfate disodium 0.05% (23) Sodium chondroitin sulfate 0.001% (24) Heparinoid 0.1% (25) Trisodium Hydroxyethylethylenediaminetriacetate 0.1% (26) Phenoxyethanol 0.6% (27) Methylparaben 0.1% (28) Purified water remainder

[0046] (Production method) (5) to (11) were heated to 70°C and uniformly dissolved (Liquid A). (12) to (27) were added to a portion of (28), heated to 70°C, and uniformly dissolved (Liquid B). Liquid B was added to Liquid A, and the mixture was dispersed using a homomixer until uniform, followed by cooling to 35°C (Liquid C). (1) to (4) were dissolved in the remainder of (28), and then added to Liquid C and uniformly dissolved to prepare an all-in-one gel.

[0047] Example 16 (Cosmetic Serum) (mass%) (1) Cyanocobalamin 0.005% (2) 1,3-butylene glycol 6.0% (3) Ethanol 5.0% (4) Dipropylene glycol 5.0% (5) Polyoxyethylene hydrogenated castor oil 0.5% (6) Potassium hydroxide 0.01% (7) Disodium edetate 0.005% (8) Phenoxyethanol 0.6% (9) Methylparaben 0.1% (10) Carboxyvinyl polymer 0.01% (11) Xanthan gum 0.1% (12) Silk extract 1.0% (13) Rosa Centifolia Flower Extract 1.0% (14) Rose flower extract 1.0% (15) Kiwi extract 1.0% (16) Peony Root Extract 1.0% (17) Soybean extract 1.0% (18) Polygonum Cuspidatum Root Extract 1.0% (19) Pomegranate Flower Extract 1.0% (20) Royal jelly extract 1.0% (21) Centella asiatica extract 1.0% (22) Retinol palmitate 0.01% (23) Sodium Hyaluronate 0.01% (24) Hydrolyzed Collagen 0.01% (25) Purified water remainder

[0048] (Production method) (1) to (24) were added to (25), heated to 70°C, and dispersed in a homomixer until uniform to prepare a cosmetic liquid.

[0049] Example 17 (whitening makeup base cream) (mass%) (1) Cyanocobalamin 0.05% (2) Nicotinamide 0.9% (3) Peony extract 0.01% (4) Rosa centifolia flower extract 0.01% (5) Glycine 8.0% (6) Scutellaria root extract 0.75% (7) D-Pantothenyl alcohol 0.05% (8) Chamomile flower extract 0.0003% (9) Gardenia Fruit Extract 2.5% (10) Licorice Root Extract 5.0% (11) Althea Root Extract 0.0007% (12) Aloe vera juice 0.85% (13) Fennel Fruit Extract 1.0% (14) Turmeric extract 0.02% (15) Coenzyme Q10 0.001% (16) Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.75% (17) Dipotassium glycyrrhizinate 0.2% (18) Ascorbic acid 2-glucoside 2.0% (19) Tranexamic acid 3.0% (20) Sodium N-stearoyl-L-glutamate 0.5% (21) Sorbitan monoisostearate 0.1% (22) PEG-10 glyceryl triisostearate 0.2% (23) PEG-60 hydrogenated castor oil 0.9% (24) Carboxyvinyl polymer 0.1% (25) Xanthan gum 0.01% (26) Hydrophobized hydroxypropyl methylcellulose 0.01% (27) Potassium hydroxide 0.02% (28) L-Arginine 0.01% (29) Citric acid 0.01% (30) Dipotassium phosphate 0.04% (31)Tartaric acid 0.01% (32) Triethanolamine 0.02% (33) Ethylparaben 0.05% (34) Methylparaben 0.05% (35) Phenoxyethanol 0.5% (36) 3-O-Ethyl ascorbic acid 0.01% (37) Retinol palmitate 0.05% (38) dl-α-Tocopherol Nicotinate 0.05% (39) Mineral oil 7.0% (40) Octyldodecyl myristate 2.0% (41) Squalane 1.0% (42) Tri(caprylic / capric / myristic / stearic acid) Glyceryl Glyceryl 0.5% (43) Zinc oxide 0.1% (44) Di(phytosteryl / isostearyl / ) dilinoleate Cetyl / Stearyl / Behenyl) 0.3% (45) White Beeswax 1.2% (46) Sodium cetyl sulfate 0.5% (47) Phenyl trimethicone 0.3% (48) Methylphenylpolysiloxane 1.0% (49) Diphenyl trimethicone 0.1% (50) Purified water remainder

[0050] (Production method) (20) to (35) and a portion of (50) were heated to approximately 80°C and stirred to dissolve uniformly (liquid A). (36) to (49) were heated to approximately 80°C and stirred to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed using a homomixer. The mixture was then cooled, and a solution of (1) to (19) in the remainder of (50) at 40°C was added and further dissolved uniformly. The mixture was again cooled to 30°C to prepare a whitening makeup base cream.

Claims

1. A topical skin preparation containing the following components (A) and (B): (A) Cyanocobalamin (B) Retinol palmitate

2. The amount of component (A) is 0.0001 to 2% by mass relative to the total mass of the topical skin preparation, The topical skin preparation according to claim 1, wherein the amount of component (B) is 0.000001 to 1% by mass relative to the total mass of the topical skin preparation.

3. 3. The external skin preparation according to claim 1, wherein the ratio (A / B) of the amount of component (A) to the amount of component (B) is 200 or less.

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