Cleaning agent composition for tableting molds, multi-composition cleaning agent for tableting molds, and cleaning method using the same.

Abstract

The present invention aims to provide a cleaning agent composition for tablet molds that is excellent in cleaning complex contaminants adhering to tablet molds, in suppressing foaming during cleaning of tablet molds, and in rinsing, a multi-composition type cleaning agent for tablet molds, and a method for cleaning tablet molds using these. [Solution] A cleaning agent composition for tablet molds comprising at least a specific component (A) and a specific component (B), wherein component (B) is an alcohol having 6 to 24 carbon atoms.

Description

[Technical Field]

[0001] The present invention relates to a cleaning agent composition for tablet molds, a multi-composition type cleaning agent for tablet molds, and a method for cleaning tablet molds using the same. [Background technology]

[0002] A tablet press, which molds tablets into a predetermined shape or imprints an image on the surface of a tablet, is a device in which a large number of dies that open in the vertical direction are arranged, and a pair of upper and lower punches corresponding to each die are arranged to move toward and away from each other in the vertical direction, a predetermined amount of drug powder is supplied to the die, and a predetermined pressure is applied to the pair of punches to mold the tablet. The tablet molds mounted on tablet presses accumulate a complex deposit consisting of grease, which is a lubricant for the molds, and lubricant components contained in the drug powder. This complex deposit is extremely stubborn and difficult to remove, posing a challenge. In such a tablet press, the die and punch components for the tablet press (hereinafter referred to as "tablet press dies") are cleaned each time the type of tablet to be molded is changed or at the end of each day's work. When cleaning such tablet molds, cleaning equipment is often used, and cleaning equipment and cleaning methods for tablet molds are disclosed in Patent Documents 1 and 2.

[0003] Patent Document 1 discloses a method and apparatus for cleaning the surface of a tablet mold by spraying fine particles of dry ice, generated using liquefied carbon dioxide, from the tip of a spray nozzle toward the surface of the tablet mold to be cleaned. Patent Document 2 discloses a method and apparatus for cleaning tablet molds, which involves placing the tablet mold, a dry abrasive, and an additive into a high-speed centrifugal barrel polishing machine and rotating the high-speed centrifugal barrel polishing machine for a predetermined time. However, with cleaning methods that rely on physical action, such as those disclosed in Patent Documents 1 and 2, there is a concern that fine scratches may occur on the surface of the tablet mold. Furthermore, the cleaning performance of complex contaminants is insufficient in either method, and further improvements in cleaning performance are needed. Furthermore, in order to enhance the detergency and cleaning efficiency of dirt, an automatic cleaning device for tablet molds that sprays cleaning liquid onto the tablet molds at high pressure is known. However, for the cleaning liquid used in such a device, defoaming properties are also required to prevent a decrease in water pressure due to the mixing of bubbles. In addition, in order to prevent the mold cleaning agent from mixing into the tablets molded by the tablet mold, it is also required that the mold cleaning agent can be removed by rinsing.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] Detergents for bathrooms and living room floors are required to have rich foaming, but conversely, defoaming properties are required for detergents for tablet molds. And the dirt on the tablet mold is a composite dirt with different components from the dirt on the floor or bathroom of a residence, and it is a very strong and difficult-to-remove dirt. An object of the present invention is to provide a cleaning agent composition for tablet molds, a multi-composition type cleaning agent for tablet molds, and a method for cleaning a tablet mold using these, which are excellent in the detergency of the above-mentioned composite dirt adhering to the tablet mold, defoaming properties during tablet mold cleaning, and rinsability. In the present invention, the solid content refers to the residue (mass %) after heating and drying at 105 °C for 3 hours.

Means for Solving the Problems

[0006] As a result of intensive studies, the present inventor has found that the above problems can be solved by the invention described below, and has completed the present invention.

[0007] The present invention is characterized by the following points. [1] A cleaning agent composition for tablet molds comprising at least component (A) and component (B), (A) Component is at least one selected from the group consisting of compounds represented by general formula (1) and compounds represented by general formula (2), (B) Component is an alcohol with 6 to 24 carbon atoms. A cleaning agent composition for tablet molds. [ka] (In general formula (1), R 1 R is an alkyl or alkenyl group having 6 to 22 carbon atoms. 2 R is an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms. 3 and R 4 Each of these is independently an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 1 to 3 carbon atoms, and Z m- (This is an m-valence anion, where m represents the valence of Z and is an integer between 1 and 3.) [ka] (In general formula (2), R 5 and R 6 Each of these is independently an alkyl or alkenyl group having 8 to 14 carbon atoms, and X n- (X is an n-valent anion, where n represents the valency of X and is an integer between 1 and 3.) [2] The tablet mold cleaning agent composition according to [1] above, wherein the mass ratio of component (A) to component (B) (A) / (B) is 1 / 10 to 2 / 1. [3] The cleaning agent composition for tablet molds according to [1] above, further comprising a solvent. [4] A method for cleaning a tablet mold using any one of the tablet mold cleaning compositions described in [1] to [3] above. [5] A multi-composition cleaning agent for tablet molds comprising at least composition A containing component (A) and composition B containing component (B), Component (A) is at least one selected from the group consisting of a compound represented by the general formula (1) and a compound represented by the general formula (2). Component (B) is an alcohol having 6 to 24 carbon atoms. Cleaning agent for multi-composition type tablet molds.

Chemical formula

Chemical formula

Chemical formula

[0008] The present invention provides a cleaning agent composition for tablet molds and a multi-composition type cleaning agent for tablet molds that exhibits excellent cleaning properties against very strong and difficult-to-remove complex contaminants adhering to tablet molds, as well as excellent foam suppression and rinsing properties during cleaning of tablet molds. Furthermore, because the tablet mold cleaning agent composition and the multi-composition type tablet mold cleaning agent of the present invention have excellent cleaning properties, cleaning by physical actions such as polishing becomes unnecessary, and as a result, the tablet mold is less likely to be scratched. Furthermore, its superior foam-suppressing properties help to reduce foam scattering when cleaning tablet molds, especially when using a cleaning machine, thereby lowering cleaning costs for the cleaning machine and its surrounding areas. Furthermore, the excellent rinsability allows for a reduction in the rinsing time of the tablet mold, and also prevents the contamination of the tablet mold cleaning agent composition and the multi-composition type tablet mold cleaning agent of the present invention into the tablet product. [Modes for carrying out the invention]

[0009] The present invention relates to a cleaning agent composition for tablet molds, a multi-composition type cleaning agent for tablet molds, and a method for cleaning tablet molds using the same.

[0010] <Cleaning agent composition for tablet molds> The cleaning agent composition for tablet molds of the present invention contains at least one component (A) selected from the group consisting of compounds represented by the following general formula (1) and compounds represented by general formula (2), and at least one component (B) which is an alcohol having 6 to 24 carbon atoms. [ka] (In general formula (1), R 1 The group is preferably an alkyl or alkenyl group having 6 to 22 carbon atoms, R 2 R is preferably an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms. 3 and R 4 Each of these is preferably an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 1 to 3 carbon atoms, Z m- (where m is an m-valence anion, m represents the valence of Z, preferably an integer between 1 and 3.)

[0011] [ka] (In general formula (2), R 5 and R 6 Each of these is preferably an alkyl group or alkenyl group having 8 to 14 carbon atoms, X n- (where n is an n-valent anion, n represents the valency of X, and is preferably an integer between 1 and 3.)

[0012] The content of component (A) in the tablet mold cleaning agent composition is not particularly limited, but is preferably 0.002 to 70% by mass, more preferably 0.004 to 30% by mass, even more preferably 0.01 to 15% by mass, particularly preferably 0.02 to 8% by mass, and most preferably 0.02 to 5% by mass. In this case, the content of component (A) is expressed in terms of solid content (solute). If component (A) consists of two or more components, the total content of component (A) should be within the above range. If the content is less than the above range, the cleaning performance may decrease, and if it is more than the above range, the foam-suppressing effect may decrease.

[0013] The content of component (B) in the tablet mold cleaning agent composition of the present invention is not particularly limited, but is preferably 0.001 to 90% by mass, more preferably 0.002 to 80% by mass, even more preferably 0.005 to 50% by mass, and particularly preferably 0.01 to 30% by mass. If the content is less than the above range, the anti-foaming properties may decrease, and if the content is more than the above range, it will not affect the effects of the present invention, but the spreadability in water may be poor. If component (B) consists of two or more components, the total content of component (B) should be within the above range.

[0014] The mass ratio (A) / (B) of component (A) to component (B) in the tablet mold cleaning agent composition is preferably 1 / 10 to 2 / 1, more preferably 1.3 / 10 to 1.7 / 1, even more preferably 1.3 / 10 to 1 / 1, particularly preferably 1.3 / 10 to 3 / 5, and most preferably 1.3 / 10 to 3 / 10.

[0015] The cleaning agent composition for tablet molds of the present invention may contain a solvent. Water and / or aqueous solvents are preferred as solvents.

[0016] The total content of component (A) and component (B) in the tablet mold cleaning agent composition is preferably 0.003 to 90% by mass, more preferably 0.006 to 60% by mass, even more preferably 0.01 to 50% by mass, particularly preferably 0.03 to 30% by mass, and particularly preferably 3 to 20% by mass. If the content is less than the above range, the cleaning performance may decrease. If the content is more than the above range, it will not affect the effects of the present invention, but the spreadability in water may be poor.

[0017] The pH of the tablet mold cleaning agent composition of the present invention is not particularly limited, but in order to maintain the rust prevention properties of the tablet mold, which is the object to be cleaned, the pH of the tablet mold cleaning agent composition may be adjusted to be in the range of 3 to 12.

[0018] Furthermore, the tablet mold cleaning agent composition of the present invention may optionally contain components such as surfactants, solubilizers (hydrotropes), rust inhibitors, pH adjusters, chelating agents, corrosion inhibitors, pigments, fragrances, preservatives / fungal agents, and viscosity modifiers, as long as they do not hinder the objectives of the present invention.

[0019] <Multi-composition tablet mold cleaning agent> The multi-composition tablet mold cleaning agent of the present invention is a cleaning agent comprising at least composition A containing component (A) above and composition B containing component (B) above. Composition A and Composition B can be mixed before use.

[0020] The multi-composition tablet mold cleaning agent of the present invention may further contain a solvent. The solvent may be contained in composition A and / or composition B, and water and / or an aqueous solvent are preferred as the solvent.

[0021] The cleaning agent for multi-component tablet molds allows for adjustment of the mass ratio (A) / (B) of component (A) to component (B) in the cleaning agent by adjusting the concentration of component (A) in composition A, the concentration of component (B) in composition B, and the mass ratio of composition A / composition B. The mass ratio (A) / (B) of component (A) to component (B) in a multi-composition tablet mold cleaning agent prepared by mixing at least composition A and composition B is preferably 1 / 10 to 2 / 1, more preferably 1.3 / 10 to 1.7 / 1, even more preferably 1.3 / 10 to 1 / 1, particularly preferably 1.3 / 10 to 3 / 5, and most preferably 1.3 / 10 to 3 / 10.

[0022] In a multi-composition tablet mold cleaning agent prepared by mixing at least composition A and composition B, the total content of component (A) and component (B) is preferably 0.003 to 90% by mass, more preferably 0.006 to 60% by mass, even more preferably 0.01 to 50% by mass, particularly preferably 0.03 to 30% by mass, and particularly preferably 3 to 20% by mass. If the content is less than the above range, the cleaning performance may decrease. If the content is more than the above range, it will not affect the effects of the present invention, but the spreadability in water may be poor.

[0023] The pH of the multi-component tablet mold cleaner prepared by mixing at least composition A and composition B is not particularly limited, but in order to maintain the rust prevention properties of the tablet mold being cleaned, the pH of the multi-component tablet mold cleaner may be adjusted to be in the range of 3 to 12.

[0024] Furthermore, the multi-composition tablet mold cleaning agent of the present invention may optionally contain components such as surfactants, solubilizers, rust inhibitors, pH adjusters, chelating agents, corrosion inhibitors, dyes, fragrances, preservatives / fungal agents, viscosity modifiers, etc., to the extent that they do not hinder the objectives of the present invention. These can be contained in composition A and / or composition B.

[0025] [Composition A] Composition A is a composition containing at least the above-mentioned component (A). The content of component (A) in composition A is not particularly limited, but when it is mixed with composition B to prepare a cleaning agent for multi-composition tablet molds, it is preferable that the content of composition A in the cleaning agent for multi-composition tablet molds be 0.002 to 70% by mass, more preferably 0.004 to 30% by mass, even more preferably 0.01 to 15% by mass, particularly preferably 0.02 to 8% by mass, and most preferably 0.02 to 5% by mass. In this case, the content of component (A) represents the content on a solid content (solute) basis. If component (A) consists of two or more components, the total content of component (A) should be within the above range. If the content is less than the above range, the cleaning performance may decrease, and if it is more than the above range, the foam-suppressing effect may decrease.

[0026] [Composition B] Composition B is a composition containing at least the above-mentioned component (B). The content of component (B) in composition B is not particularly limited, but when it is mixed with composition A to prepare a cleaning agent for multi-composition tablet molds, the content of composition B in the cleaning agent for multi-composition tablet molds is preferably 0.001 to 90% by mass, more preferably 0.002 to 80% by mass, even more preferably 0.005 to 50% by mass, and particularly preferably 0.01 to 30% by mass. If the content is less than the above range, the anti-foaming properties may decrease, and if it is more than the above range, it will not affect the effects of the present invention, but the spreadability in water may be poor. If component (B) consists of two or more components, the total content of component (B) should be within the above range.

[0027] <Details of each ingredient>

[0028] [(A) component] Component (A) in the present invention is at least one selected from the group consisting of compounds represented by general formula (1) and compounds represented by general formula (2).

[0029] In general formula (1), R 1 A C6-C22 alkyl or alkenyl group is preferred, but to obtain higher cleaning performance, R 1 The number of carbon atoms is more preferably 8 to 18, even more preferably 10 to 20, particularly preferably 12 to 18, and most preferably 12 to 15. 1 The chain may be linear or branched.

[0030] In general formula (1), R 2 Preferably, R is an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms, but in order to obtain higher cleaning performance, 2 More preferably, the group is an alkyl group having 1 to 3 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 2 carbon atoms.

[0031] In general formula (1), R 3 and R 4 Each of these is preferably an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 1 to 3 carbon atoms, but in order to obtain higher cleaning performance, R 3 , and R 4 Each of these is independently preferably an alkyl group having 1 to 3 carbon atoms, or a hydroxyalkyl group having 1 to 2 carbon atoms, even more preferably an alkyl group having 1 to 3 carbon atoms, and particularly preferably an alkyl group having 1 to 2 carbon atoms.

[0032] In general formula (1), Z m- is an m-valent anion, where m represents the valence of Z and is preferably an integer between 1 and 3. However, to obtain higher cleaning and foam-suppressing properties, alkyl phosphate ions, halogen ions, alkyl sulfate ions, and p-toluenesulfonate ions with a total of 1 to 6 carbon atoms in the alkyl group are more preferable.

[0033] Z m-Examples include halogen ions, sulfate ions, nitrate ions, phosphate ions, alkyl phosphate ions (monoesters, diesters, and mixtures thereof) in which the total number of carbon atoms in the alkyl group is 1 to 6, benzenesulfonate ions, alkylbenzenesulfonate ions in which the total number of carbon atoms in the alkyl group is 8 to 16, p-toluenesulfonate ions, xylenesulfonate ions, benzoate ions, adipicate ions, lactate ions, hydroxypropionate ions, and alkyl sulfate ions in which the total number of carbon atoms in the alkyl group is 1 to 6.

[0034] Specific examples of compounds represented by general formula (1) include dimethylalkyl (mixture of carbon atoms 12-16) hydroxyethylammonium butyl phosphate, dimethylalkyl (mixture of carbon atoms 12-16) hydroxyethylammonium 2-ethylhexyl phosphate, N-tallow hydrogenated alkyl (mixture of carbon atoms 10-18)-N,N-dihydroxyethyl-N-ethylammonium ethyl sulfate, N,N,N-trishydroxyethyl-N-alkyl (mixture of carbon atoms 8-18) ammonium p-toluenesulfonate, alkyl (mixture of carbon atoms 12-16) dimethylbenzylammonium chloride, alkyl (mixture of carbon atoms 8-18) dimethylethylammonium ethyl sulfate, cetyltrimethylammonium chloride, lauryltrimethylammonium chloride, and the like. As the compound represented by general formula (1), any one of the above may be used alone, or two or more may be used in any proportion.

[0035] In general formula (2), R 5 and R 6 Each of these is preferably an alkyl group or alkenyl group having 8 to 14 carbon atoms, but to obtain higher cleaning performance, R 5 and R 6 The number of carbon atoms in each component is more preferably 8 to 12, and even more preferably 10 to 12. 5 The chain may be linear or branched.

[0036] In general formula (2), X n- A is an n-valent anion, where n represents the valence of X and is preferably an integer between 1 and 3. However, to obtain higher cleaning and foam-suppressing properties, alkyl phosphate ions, halogen ions, alkyl sulfate ions, and p-toluenesulfonate ions with a total of 1 to 6 carbon atoms in the alkyl group are more preferable.

[0037] X n- Examples include halogen ions, sulfate ions, nitrate ions, phosphate ions, alkyl phosphate ions (monoesters, diesters, or mixtures thereof) in which the total number of carbon atoms in the alkyl group is 1 to 6, benzenesulfonate ions, alkylbenzenesulfonate ions in which the total number of carbon atoms in the alkyl group is 8 to 16, p-toluenesulfonate ions, xylenesulfonate ions, benzoate ions, adipicate ions, lactate ions, hydroxypropionate ions, and alkyl sulfate ions in which the total number of carbon atoms in the alkyl group is 1 to 6.

[0038] Specific examples of compounds represented by general formula (2) include didecyldimethylammonium chloride. As the compound represented by general formula (2), any one of the above may be used alone, or two or more may be used in any proportion.

[0039] [(B) Component] In the present invention, component (B) is preferably an alcohol having 6 to 24 carbon atoms, but in order to obtain better foam suppression, the number of carbon atoms in component (B) is more preferably 6 to 20, even more preferably 10 to 20, and particularly preferably 12 to 18. If the number of carbon atoms is less or more than the above range, the foam suppression may decrease. The carbon chain of component (B) may be linear or branched, but branched is preferred. Furthermore, the carbon chain of component (B) may contain unsaturated bonds.

[0040] Specific examples of component (B) include hexyl alcohol (6 carbon atoms), hepticyl alcohol (7 carbon atoms), octyl alcohol (8 carbon atoms), nonyl alcohol (9 carbon atoms), decyl alcohol (10 carbon atoms), 2-butyloctyl alcohol (12 carbon atoms), 2-hexyldecyl alcohol (16 carbon atoms), oleyl alcohol (18 carbon atoms), isostearyl alcohol (18 carbon atoms), etc. Component (B) may be used individually or mixed in any proportion. The cleaning agent composition for tablet molds of the present invention may contain one of the components (B) alone, or it may contain two or more in combination.

[0041] [solvent] The solvent in this invention is water and / or an aqueous solvent. Of these, water alone or a mixed solvent of water and an aqueous solvent is preferred. (water) The water used in this invention is not particularly limited, but for example, tap water, deionized water (ion-exchanged water), pure water, ultrapure water, distilled water, etc. may be used. Any one of the above types of water may be used alone, or two or more types may be mixed in any proportion. (Water-based solvent) The aqueous solvent in this invention is an organic solvent that has excellent compatibility with water, and is an organic solvent other than component (B) and the solubilizer. Examples of aqueous solvents include ethylene glycol, propylene glycol, and glycerin. For the aqueous solvent, one of the above types may be used alone, or two or more types may be mixed in any proportion.

[0042] [Surfactants] Examples of surfactants in the present invention include nonionic surfactants such as higher alcohol alkylene oxide adducts, alkylphenol alkylene oxide adducts, fatty acid alkylene oxide adducts, polyhydric alcohol fatty acid ester alkylene oxide adducts, and higher alkylamine alkylene oxide adducts; and amphoteric surfactants such as alkylamino fatty acid salts and alkyl betaines. Specific examples of surfactants include polyoxyethylene (5) alkyl (12-14 carbon atoms) ether and polyglyceryl stearate. Any one of the above surfactants may be used alone, or two or more may be mixed in any proportion. These surfactants may be used individually or in combination of two or more types.

[0043] [Solubilizer] The cleaning agent composition for tablet molds and the multi-composition cleaning agent for tablet molds of the present invention may contain a solubilizer (hydrotrope agent) for the purpose of improving the transparency stability of the appearance at room temperature. Specific examples of hydrotropes include, but are not limited to, polyethylene glycol, p-toluenesulfonate, and cumenesulfonate. These solubilizing agents may be used individually or in combination of two or more.

[0044] [Rust inhibitor] Examples of rust inhibitors in the present invention include, but are not limited to, benzoic acid, aliphatic carboxylic acids, fatty acid dicarboxylic acids, benzotriazoles, and salts thereof. Specific examples of the compounded part include sodium benzoate. These rust inhibitors may be used individually or in combination of two or more types.

[0045] [pH adjuster] In the present invention, any pH adjusting agent that can be used is a metal hydroxide such as sodium hydroxide or potassium hydroxide; an alkanolamine such as monoethanolamine; an organic acid such as citric acid; or an inorganic acid such as phosphoric acid. These pH adjusters may be used individually or in combination of two or more types.

[0046] <Objects to be cleaned> The cleaning targets of the tablet mold cleaning agent composition and multi-component tablet mold cleaning agent of the present invention are tablet molds such as punches and dies used in tablet presses. Tablet molds widely used are those made of steel as the base material and having a thin film coating on the surface of the base material. Examples of coatings on the surface of tablet molds include plating such as chromium plating, zinc plating, and nickel plating; film deposition of titanium nitride, titanium aluminum nitride, and chromium nitride; and metal oxide coatings such as aluminum and zinc-plated steel. When such a tablet press is used for a long period of time, a complex deposit of contaminants will accumulate on the surface of the press. The cleaning agent composition for tablet molds and the multi-composition cleaning agent for tablet molds of the present invention can be used for tablet molds of any of the aforementioned materials.

[0047] [Combined contamination on tablet molds] The sides of the punches of the tablet presses are coated with lubricating oil (grease) mainly composed of synthetic oil, mineral oil, vegetable oil, and animal oil to improve lubrication between the tablet presses themselves and between the tablet presses and the tablet press body. In addition to the drug components, the powder supplied to the dies contains lubricating agents such as magnesium stearate and talc (hydrated magnesium silicate) to improve the release properties of the tablets. Furthermore, the tableting mold can become locally hot due to friction, etc., and dirt can be rubbed against the die or punch under high pressure, resulting in the adhesion of a composite contaminant formed by a mixture of the grease and the lubricant component to the tableting mold. On the other hand, dirt on the floors and bathrooms of residences is mainly composed of sebum and soap components, and is not particularly caused by scrubbing with high temperature and pressure. Therefore, the combined deposits in tablet molds are much more stubborn than those found on floors or in bathrooms in homes, and cannot be easily removed with ordinary cleaning agents.

[0048] <Regarding dilution when using tablet mold cleaning agent compositions and multi-component tablet mold cleaning agents> The tablet mold cleaning agent composition and multi-composition tablet mold cleaning agent of the present invention may be used as is, or may be diluted with water and / or an aqueous solvent before use for cleaning tablet molds. The water used for dilution can be, but is not limited to, tap water, deionized water (ion-exchanged water), pure water, ultrapure water, or distilled water. The aqueous solvent used for dilution may be, but is not limited to, an aqueous solvent contained in a tablet mold cleaning agent composition or a multi-composition type tablet mold cleaning agent. When using a cleaning agent composition for tableting molds or a multi-composition type cleaning agent for tableting molds after diluting with water and / or an aqueous solvent, it is preferable to dilute it with water alone or a mixed solvent of water and an aqueous solvent.

[0049] When a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent is diluted with water and / or an aqueous solvent for use in cleaning tablet molds, the dilution ratio is not particularly limited, as long as it is within a concentration range in which the tablet mold cleaning agent composition or multi-component tablet mold cleaning agent can exert its effect. For example, it is preferable to dilute the water / tablet mold cleaning agent composition or water / multi-component tablet mold cleaning agent by a mass ratio of 1 / 1 to 1000 / 1, more preferably by 1 / 1 to 200 / 1, and even more preferably by 1 / 1 to 100 / 1.

[0050] The content of component (A) in the diluted tablet mold cleaning agent composition or multi-composition tablet mold cleaning agent is preferably 0.002 to 5% by mass, more preferably 0.01 to 1.5% by mass, even more preferably 0.02 to 1% by mass, and particularly preferably 0.02 to 0.5% by mass. In this case, the content of component (A) represents the content on a solid (solute) basis. Furthermore, if component (A) consists of two or more components, the total content of component (A) should be within the above range. If the content is less than the above range, the cleaning performance may decrease, and if it is more than the above range, the foam-suppressing effect may decrease.

[0051] The content of component (B) in the diluted tablet mold cleaning agent composition or multi-composition tablet mold cleaning agent is preferably 0.001 to 15% by mass, more preferably 0.002 to 10% by mass, even more preferably 0.005 to 5% by mass, and particularly preferably 0.01 to 3% by mass. If component (B) consists of two or more components, the total content of component (B) should be within the above range. If the content is less than the above range, the anti-foaming properties may decrease. If the content is more than the above range, it will not affect the effects of the present invention, but the spreadability in water may be poor.

[0052] The mass ratio (A) / (B) of component (A) to component (B) in the diluted tablet mold cleaning agent composition or multi-component tablet mold cleaning agent is preferably 1 / 10 to 2 / 1, more preferably 1.3 to 1.7 / 1, even more preferably 1 / 10 to 1 / 1, particularly preferably 1 / 10 to 3 / 5, and most preferably 1 / 10 to 3 / 10.

[0053] The pH of the diluted tablet mold cleaning agent composition or the multi-composition tablet mold cleaning agent is not particularly limited, but may be adjusted to a range of 3 to 12 in order to maintain the rust prevention properties of the tablet mold being cleaned.

[0054] <Method for cleaning tablet compression molds> The method for cleaning tablet molds according to the present invention is not particularly limited as long as it includes a step of bringing the cleaning agent composition for tablet molds or a multi-composition type cleaning agent for tablet molds according to the present invention into contact with the object to be cleaned. Examples of the cleaning methods include spraying a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent onto the surface of the object to be cleaned using an instrument equipped with a nozzle or the like; simply wetting or immersing the surface of the object to be cleaned with a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent; immersing the surface of the object to be cleaned in a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and further performing ultrasonic treatment; immersing the surface of the object to be cleaned in a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and further stirring; wetting the surface of the object to be cleaned with a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and polishing it; and impregnating a base such as a wipe with a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and using it as a cleaning item. Of these methods, the method of spraying a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent onto the surface of the object to be cleaned using an instrument equipped with a nozzle, the method of immersing the surface of the object to be cleaned in a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and then performing ultrasonic treatment, and the method of immersing the surface of the object to be cleaned in a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent and then stirring are particularly suitable. [Examples]

[0055] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0056] <Raw materials> [(A) Ingredients, etc.] (Component (A) represented by general formula (1)) A1: Dimethylalkyl (a mixture of carbon atoms with 12 to 16 carbon atoms) hydroxyethylammonium butyl phosphate salt ("Nikkanon RB Conc," manufactured by Nikka Chemical Co., Ltd., aqueous solution with 50% solids by mass) A2: Alkyl (mixture of C12-C16 atoms) dimethylbenzylammonium chloride ("Nikkanon 50", manufactured by Nikka Chemical Co., Ltd., aqueous solution with 50% solids by mass) A3: Dimethylalkyl (mixture of carbon atoms with 12-16 atoms) hydroxyethylammonium 2-ethylhexyl phosphate salt (Synthesis Example 1) A4: Alkyl (mixture of C8-C18 atoms) dimethylethylammonium ethyl sulfate (synthesis example 2) A5: N,N,N-trishydroxyethyl-N-alkyl (mixture of carbon atoms with 8-18 atoms) ammonium p-toluenesulfonate (Synthesis Example 3) A6: N-Hydrogenated alkyl tallow (mixture of 10-18 carbon atoms)-N,N-dihydroxyethyl-N-ethylammonium ethyl sulfate (Synthesis Example 4) (Component (A) represented by general formula (2)) A7: Didecyldimethylammonium chloride ("Lipoguard 210-80E", manufactured by Lion Corporation, 95% solids by mass aqueous solution) (others) a1: Distearyldimethylammonium chloride ("Cation DSV", manufactured by Sanyo Chemical Industries, Ltd., solids content 100% by mass)

[0057] [(B) Ingredients, etc.] ((B) component) • B1: 2-Butyloctyl alcohol ("ISOFOL12", manufactured by Sasol) • B2: Oleyl alcohol ("Angecol 90N", manufactured by Shin Nippon Rika Co., Ltd.) • B3: Octyl alcohol ("Conol 10WS", manufactured by Shin Nippon Rika Co., Ltd.) • B4: Hexyl alcohol ("n-hexanol", manufactured by Toyo Gosei Kogyo Co., Ltd.) • B5: Isostearyl alcohol ("ISOFOL18T", manufactured by Sasol) (others) • b1: Ethanol b2: Polypropylene glycol 3000 ("ADEKA Polyether P-3000", manufactured by ADEKA Corporation, solids content 100% by mass) • b3: Silicone emulsion ("KM-72", manufactured by Shin-Etsu Chemical Co., Ltd., aqueous emulsion with 36% solid content by mass) ·b4: Coconut oil fatty acid ("coconut fatty acid", manufactured by NOF Corporation, solid content 100% by mass)

[0058] [Surfactants] • Polyoxyethylene (5) alkyl (12-14 carbon atoms) ether ("Softanol 50", manufactured by Nippon Shokubai Co., Ltd., 100% solids by mass, nonionic surfactant). [Hydrotrope] • Sodium xylene sulfonate ("SXA-Y", manufactured by Itochu Chemical Frontier Co., Ltd., solid content 100% by mass) [Rust inhibitor] Sodium benzoate [pH adjuster] Sodium hydroxide ·phosphoric acid

[0059] <Example of synthesis> [Composite Example 1: Composite of A3] First, 1400g of 2-ethylhexyl alcohol was placed in a pressure vessel, the line mixer circulation was started, and nitrogen gas purging was performed. Then, 540 g of phosphorus pentoxide was added over 2 hours at a temperature of 55°C or lower, the temperature was raised to 60°C and stirred for more than 2 hours, and the mixture was kept at 75-80°C for 3 hours to obtain 2-ethylhexyl phosphate ester (100% by mass of solids). Next, 550g of N,N-dimethylmyristylamine ("Farmin DM4098", manufactured by Kao Corporation), 350g of 3-methoxy-3-methyl-1-butanol ("Solfit", manufactured by Kuraray Co., Ltd.), 600g of the 2-ethylhexyl phosphate ester obtained above, and 200g of water were added, and the mixture was heated to 60°C and stirred. Then, after purging with nitrogen gas and raising the temperature to 90°C, 150g of ethylene oxide ("ethylene oxide," manufactured by Mitsubishi Chemical Corporation) was added and the mixture was reacted at 90°C for 1 hour to obtain a solution (70% by mass of solids) of dimethylalkyl (C12-C16) hydroxyethylammonium 2-ethylhexyl phosphate salt (A3) dissolved in water and 3-methoxy-3-methyl-1-butanol.

[0060] [Composite Example 2: Composite of A4] First, 650g of coconut alkyldimethylamine ("Farmin DM-24C," manufactured by Kao Corporation) was placed in a pressure vessel, and the vessel was purged with nitrogen gas. Then, after raising the temperature to 50-60°C, 400g of diethyl sulfuric acid was added dropwise. After the dropwise addition of diethyl sulfuric acid was complete, the temperature was raised to 80-90°C and the reaction was allowed to proceed for 1 hour to obtain coconut alkyldimethylethylammonium ethyl sulfate (A4, solid content 100% by mass).

[0061] [Synthesis Example 3: Synthesis of A5] First, 650g of coconut alkylamine ("Farmin CS," manufactured by Kao Corporation) was added to a pressure vessel, and nitrogen purging was performed. Then, the temperature was raised to 130°C, and while maintaining the reaction temperature at 140-150°C and the pressure at 0.4 MPa or less, 300 g of ethylene oxide ("ethylene oxide," manufactured by Mitsubishi Chemical Corporation) was blown into the pressure vessel over approximately 3 hours. After that, the mixture was allowed to mature until the pressure became constant, yielding polyoxyethylene(2) coconut alkylamine (100% solids by mass). Next, 2900g of the synthesized polyoxyethylene(2) coconut alkylamine, 2650g of p-toluenesulfonic acid ("PTS 70% solution," manufactured by Kounan Chemical Co., Ltd.), and 2100g of water were added to a pressure vessel, mixed and dissolved, and then the temperature was raised to 80-85°C, followed by nitrogen gas purging. 700g of ethylene oxide ("ethylene oxide," manufactured by Mitsubishi Chemical Corporation) was introduced at 80-85°C, then the temperature was raised to 90-95°C and the reaction was allowed to proceed for 6 hours. After cooling to 80°C, 1300g of water was added to obtain an aqueous solution of N,N,N-trishydroxyethyl-N-coconut alkylammonium p-toluenesulfonate (A5) (solid content 52% by mass).

[0062] [Synthesis Example 4: Synthesis of A6] First, 5200g of hydrogenated beef tallow alkylamine ("ABT-R," manufactured by NOF Corporation) was placed in a pressure vessel, and the inside of the vessel was purged with nitrogen gas. Then, the temperature was raised to 130°C, and while maintaining the reaction temperature at 140-150°C and the pressure at 0.4 MPa or less, 1800 g of ethylene oxide ("ethylene oxide," manufactured by Mitsubishi Chemical Corporation) was blown into the pressure vessel over approximately 3 hours. After that, it was allowed to mature until the pressure became constant, yielding polyoxyethylene(2) beef tallow hydrogenated alkylamine (solid content 100% by mass). Next, 700 g of the synthesized polyoxyethylene(2) hydrogenated alkylamine and 250 g of 3-methoxy-3-methyl-1-butanol ("Solfit," manufactured by Kuraray Co., Ltd.) were charged into the reaction vessel, and the mixture was heated to 80-90°C and mixed. 300 g of diethyl sulfate was added dropwise in small amounts at 80-90°C, and the mixture was allowed to react for 2 hours after the addition was complete to obtain a 3-methoxy-3-methyl-1-butanol solution (20% by mass of solids) of N-hydrogenated alkyl-N,N-dihydroxyethyl-N-ethylammonium ethyl sulfate (A6).

[0063] <Preparation and evaluation of cleaning agent compositions for tablet molds> [Example 1] A cleaning agent composition for tablet molds was obtained by mixing the following parts by mass: A1 as component (A), B1 as component (B), sodium hydroxide and phosphoric acid as pH adjusters, and water as a solvent. In this case, since A1 is in the form of an aqueous solution with a solid content of 50% by mass, 2.5 parts by mass of A1 are mixed in, calculated based on its solid content, so 5 parts by mass of A1 were mixed as the final product. Furthermore, since the tablet mold cleaning agent composition contains 2.5 parts by mass of water derived from A1, 89.73 parts by mass of water were mixed in so that the total amount of water, including the water derived from A1, would be 92.23 parts by mass. A1: 2.5 parts by mass B1 :5 parts by mass Sodium hydroxide: 0.12 parts by mass Phosphoric acid: 0.15 parts by mass Water: 92.23 parts by mass The cleaning properties, anti-foaming properties, rinsability, and transparency at room temperature of the obtained tablet mold cleaning agent compositions were evaluated. The results are shown in Table 1.

[0064] [Examples 2-21, Comparative Examples 1-6] Tablet mold cleaning agent compositions were obtained and evaluated in the same manner as in Example 1, according to the compositions listed in Tables 1 and 2. If any raw materials were solid at room temperature (25°C), they were mixed while being heated to their melting point. The content (parts by mass) of water, B1-B5, and other ingredients other than b1 shown in the table are calculated on a solid content basis.

[0065] <Preparation and evaluation of cleaning agents for multi-composition tablet molds> [Example 22] Composition A for cleaning agent for multi-component tablet molds was obtained by mixing the following parts by mass: A1 as component (A), sodium hydroxide and phosphoric acid as pH adjusters, and water as a solvent. A1: 2.5 parts by mass Sodium hydroxide: 0.12 parts by mass Phosphoric acid: 0.15 parts by mass Water: 46.12 parts by mass In this case, since A1 is in the form of an aqueous solution with a solid content of 50% by mass, 2.5 parts by mass of A1 are mixed in, calculated based on its solid content, so 5 parts by mass of A1 were mixed as the final product. Furthermore, since the tablet mold cleaning agent composition contains 2.5 parts by mass of water derived from A1, 43.61 parts by mass of water were mixed in so that the total amount of water, including the water derived from A1, would be 46.11 parts by mass. Then, the following parts by mass of B1 as component (B) and water as a solvent were mixed to obtain composition B for cleaning agent for multi-component tablet molds. B1 :5 parts by mass Water: 46.11 parts by mass The cleaning properties, foam suppression, rinsability, and transparency stability at room temperature of the multi-composition tablet mold cleaning agents obtained from Composition A and Composition B were evaluated. The results are shown in Table 3.

[0066] [Examples 23, 24] A multi-composition tablet mold cleaning agent was obtained by following the same procedure as in Example 22, according to the composition listed in Table 3, and was evaluated in the same manner. The content (parts by mass) of ingredients other than water and B1 shown in the table is calculated on a solid content basis.

[0067] <Rating> The following transparency stability was measured for tablet mold cleaning agent compositions or multi-component tablet mold cleaning agents. For the cleaning performance test, foam suppression test, and rinsability test, the prepared tablet mold cleaning agent composition or multi-component tablet mold cleaning agent was diluted with deionized water so that the mass ratio of deionized water / tablet mold cleaning agent composition or deionized water / multi-component tablet mold cleaning agent was 50 / 1.

[0068] [Cleaning performance test] A pseudo-compound fouling agent was prepared by mixing lubricating oil ("Anderol 6220," manufactured by Anderol) and magnesium stearate in a mass ratio of 1:1. A three-bladed propeller (stainless steel, 50mm in diameter) was used as the object to be cleaned, and the weight of the propeller was measured using a precision balance ("HR-250AZ", manufactured by A&D Co., Ltd.). First, the weight (W0) of the propeller was measured. Then, 70 mg of the simulated composite fouling agent prepared above was applied to the entire underside of one of the three propeller blades (the bottom surface when the propeller is fixed to the stirring rod), ensuring it was uniform and smooth by visual inspection, and the weight of the propeller (W1) was measured. Next, a three-bladed propeller coated with a pseudo-compound fouling agent was fixed to a stirring rod and stirred for 5 minutes at 360 rpm in a tablet mold cleaning agent composition or a multi-composition type tablet mold cleaning agent heated to 40°C. After stirring, the propeller was removed, immersed once in a bath of tap water, and then removed again after being immersed once in a bath of deionized water. The propeller was then dried using hot air from a hairdryer and by leaving it at 25°C, and its weight (W2) was measured. Then, the residual rate of the pseudo-compound stain agent was calculated using the following formula, and the cleaning performance was evaluated. Residual rate (%) = [(Propeller weight after drying) - (Propeller weight before application of simulated compound fouling agent)] / [(Propeller weight after application of simulated compound fouling agent and before washing) - (Propeller weight before application of simulated compound fouling agent)] × 100 = (W2 - W0) / (W1 - W0) × 100 The residual rate of the calculated pseudo-compound stain was scored according to the following criteria, and the cleaning performance was evaluated. Evaluation Criteria Score 5: Retention rate less than 60% Score 4: Retention rate between 60% and 70% Score 3: Retention rate between 70% and 80% Score 2: Retention rate of 80% or more, but less than 90% Score 1: Retention rate 90% or more

[0069] [Foam suppression test] 500 mL of a tablet mold cleaning agent composition or a multi-component tablet mold cleaning agent was placed in a 1 L beaker, and the height (h0) from the bottom of the beaker to the liquid level of the tablet mold cleaning agent composition or multi-component tablet mold cleaning agent was measured. The position of the commutation plate of a homomixer ("TK Homomixer," manufactured by Primix Co., Ltd.) was adjusted to match the liquid level of the tablet mold cleaning agent composition or multi-component tablet mold cleaning agent. The commutation plate was then rotated at 5000 rpm for 10 minutes to agitate and foam the tablet mold cleaning agent composition or multi-component tablet mold cleaning agent in the beaker. Immediately after the commutation plate stopped rotating, the distance (h1) from the bottom of the beaker to the top of the bubbles was measured. Then, the height of the bubbles was calculated using the following formula. Bubble height (mm) = h1 (mm) - h0 (mm) The calculated foam height was scored according to the following criteria to evaluate foam suppression. Evaluation Criteria Score 5: Bubble height less than 15mm Score 4: Bubble height 15mm or more, less than 30mm Score 3: Bubble height 30mm or more, less than 45mm Score 2: Bubble height 45mm or more, less than 60mm Score 1: Foam height of 60mm or more

[0070] [Rinsing Test] First, as a preliminary treatment, the surface of the punch (outer diameter 20 mm, length 1350 mm) of the tablet press mold was polished with kitchen paper soaked in metal polishing agent ("Pikal Neri," manufactured by Nippon Polishing Industry Co., Ltd.) to remove rust from the punch surface. Furthermore, the surface of the punch was wiped with a cloth soaked in acetone, and it was visually confirmed that there was no rust, dirt, or other contaminants on the punch surface. 400 mL of a tablet mold cleaning agent composition or a multi-composition type tablet mold cleaning agent was placed in a 400 mL mayonnaise bottle, and the punch pre-treated as described above was immersed in it and left to stand at 25°C for 2 hours. Then, the pestle was removed, immersed in a bath filled with deionized water, and taken out after 30 seconds. Finally, the surface of the punch was dried with warm air from a hairdryer, and the residue of the tablet mold cleaning agent composition or multi-composition tablet mold cleaning agent on the surface of the punch after drying was visually observed. Evaluation Criteria ○: No deposits are present on the surface of the pestle. ×: There is some residue present. -: Rinsing performance test not performed

[0071] [Room temperature appearance transparency] The tablet mold cleaning agent compositions or multi-composition tablet mold cleaning agents prepared in Examples 1, 20, and 22 were cooled to 20°C and left to stand for 1 hour. Their appearance was then visually observed. Evaluation Criteria ○: The ingredients are uniformly mixed. ×: Some of the components have settled or are suspended, resulting in an uneven distribution. -: Room temperature appearance transparency test not performed.

[0072] [Table 1]

[0073] [Table 2]

[0074] [Table 3]

[0075] <Summary of Results> The tablet mold cleaning agent compositions and multi-composition tablet mold cleaning agents of the present invention in all embodiments demonstrated an excellent balance of cleaning performance, foam suppression, and rinsability. However, the comparative detergent compositions that did not contain component (A) or component (B) in the present invention showed inferior performance in any of the following: cleaning ability, foam suppression ability, or rinsing ability. [Industrial applicability]

[0076] The cleaning agent composition and multi-composition cleaning agent for tablet molds of the present invention exhibit excellent cleaning properties, eliminating the need for mold cleaning by physical actions such as polishing. This reduces scratches on the mold surface, maintains the ability to obtain molded products with excellent surface conditions, and reduces the frequency of mold plating collection maintenance.

Claims

1. A cleaning agent composition for tablet molds containing at least component (A) and component (B), (A) Component is at least one selected from the group consisting of compounds represented by general formula (1) and compounds represented by general formula (2), (B) Component is an alcohol with 6 to 24 carbon atoms. A cleaning agent composition for tablet molds. 【Chemistry 1】 (In general formula (1), R 1 R is an alkyl or alkenyl group having 6 to 22 carbon atoms. 2 R is an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms. 3 and R 4 Each is independently an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 1 to 3 carbon atoms, Z m- (A is an m-valence anion, where m represents the valence of Z and is an integer between 1 and 3.) 【Chemistry 2】 (In general formula (2), R 5 and R 6 Each of these is independently an alkyl or alkenyl group having 8 to 14 carbon atoms, X n- (X is an n-valent anion, where n represents the valence of X and is an integer from 1 to 3.)

2. The cleaning agent composition for tablet molds according to claim 1, wherein the mass ratio (A) / (B) of component (A) to component (B) is 1 / 10 to 2 / 1.

3. The cleaning agent composition for tablet molds according to claim 1, further comprising a solvent.

4. A method for cleaning a tablet mold using the tablet mold cleaning agent composition described in any one of claims 1 to 3.

5. A multi-composition cleaning agent for tablet molds comprising at least composition A containing component (A) and composition B containing component (B), (A) Component is at least one selected from the group consisting of compounds represented by general formula (1) and compounds represented by general formula (2), (B) Component is an alcohol with 6 to 24 carbon atoms. A cleaning agent for multi-composition tablet molds. 【Transformation 3】 (In general formula (1), R 1 is an alkyl group or an alkenyl group having 6 to 22 carbon atoms, R 2 is an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms, R 3 and R 4 are each independently an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 1 to 3 carbon atoms, Z m- is an m-valent anion, m represents the valence of Z, and is an integer of 1 to 3.) 【Chemistry 4】 (In general formula (2), R 5 and R 6 Each of these is independently an alkyl or alkenyl group having 8 to 14 carbon atoms, X n- (X is an n-valent anion, where n represents the valence of X and is an integer from 1 to 3.)

6. A method for cleaning a tablet mold using a multi-composition tablet mold cleaning agent comprising at least composition A containing component (A) and composition B containing component (B), (A) Component is at least one selected from the group consisting of compounds represented by general formula (1) and compounds represented by general formula (2), (B) Component is an alcohol with 6 to 24 carbon atoms. A method for cleaning tablet molds. 【Transformation 5】 (In general formula (1), R 1 R is an alkyl or alkenyl group having 6 to 22 carbon atoms. 2 R is an alkyl group having 1 to 4 carbon atoms, a benzyl group, or a hydroxyalkyl group having 1 to 3 carbon atoms. 3 and R 4 Each is independently an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 1 to 3 carbon atoms, Z m- (A is an m-valence anion, where m represents the valence of Z and is an integer between 1 and 3.) 【Transformation 6】 (In general formula (2), R 5 and R 6 Each of these is independently an alkyl or alkenyl group having 8 to 14 carbon atoms, X n- (X is an n-valent anion, where n represents the valence of X and is an integer from 1 to 3.)

7. A method for cleaning a tablet mold according to claim 6, wherein composition A containing component (A) and composition B containing component (B) are mixed in advance before use.

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