RNA circularization

The novel RNA construct with a group I intron-based system efficiently produces circRNAs by self-circularization, addressing inefficiencies and immunogenicity issues in existing methods, enabling scalable and safer circRNA production.

JP2026500787APending Publication Date: 2026-01-08SUZHOU ABOGEN BIOSCIENCES CO LTD
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Patent Information

Application Number
JP2025538492
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-09-01
Filing Date
2023-12-29
Publication Date
2026-01-08

AI Technical Summary

Technical Problem

Existing methods for producing circular RNAs (circRNAs) are inefficient, introduce foreign fragments, and require complex optimization, making them unsuitable for large-scale production and potentially immunogenic.

Method used

A novel RNA construct with a group I intron-based circularization system that self-circularizes without foreign fragments, using a complete ribozyme core and specific nucleotide pairings to form a duplex structure, enabling efficient production of circRNAs.

Benefits of technology

The method achieves high-efficiency circularization of nucleotide sequences, reducing immunogenicity and facilitating large-scale production of circRNAs for therapeutic applications.

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Abstract

The present disclosure relates to novel RNA ribozyme constructs that encode foreign proteins or functional RNAs and have a group I intron-based circularization system, which can efficiently self-circularize without introducing foreign fragments, and methods for generating circular RNAs using the constructs.
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