A therapeutic drink containing three ingredients to build, promote and maintain gut health

Abstract

This drinking therapy aims to build, promote and maintain the intestinal microbiome (eubiosis) and consists of a drink containing at least the following ingredients: Probiotic herbal enzyme drink (probiotics), Prebiotics combined with essential vitamins, minerals and trace elements, A natural nourishing oil rich in omega-3 fatty acids and containing tocopherol. These ingredients are processed into an emulsion and the resulting beverage can be consumed regularly, preferably daily, as part of a drinking regimen.

Description

[Technical Field]

[0001] The present invention relates to a special three-component beverage that should be consumed preferably daily as part of a drinking therapy. To understand the motivation for the special composition of this beverage of the present invention and the biological and medical background behind the selection of its components, as well as to explain this drinking therapy and its effectiveness, some important definitions are provided below. Some of these definitions refer to scientific literature in square brackets. Microbiome: In a narrow sense, this refers to the totality of microbial DNA in the human body. In a broader and colloquial sense, the term "microbiome" refers to the totality of all microorganisms present in the human body. In humans, microbiomes are differentiated according to their bodily niche (gut, skin, oral cavity, vagina, etc.). The gut microbiome is located within the lumen of the outer mucus layer of the intestine. Symbiotic (commensal) microorganisms: Organisms that live in symbiosis with other organisms, consuming the same food as them, without harming them. Eubiosis: Refers to the balance of bacterial cultures in a healthy person's microbiome. Dysbiosis: refers to an imbalance in the bacterial culture of the microbiome, and is the opposite of eubiosis. Vitality: refers to the mental, physical, emotional and social capabilities of the body. Probiotics: Live, non-pathogenic microorganisms that confer a health benefit on the host, specifically the gut [1]. Prebiotics: Substances that are selectively utilized by the host's microorganisms (herein specifically the microbiome) and confer health benefits [2]. Synbiotics: refers to a mixture of probiotics and prebiotics that provides a health benefit to the host (here, specifically the gut) [3].

[0002] The human gut microbiome contains approximately 100 trillion (10 14) bacteria per gram of biomass. 10 From 10 12 The human body contains approximately 10,000 different bacterial species. Over 90% of these bacteria belong to two anaerobic phyla: Bacillota (over 75%) and Bacteriodota (over 15%), forming approximately 10,000 different commensal microbial species. The small intestine is dominated by Lactobacillus and Enterococcus, while the large intestine is dominated by Bifidobacterium, E. coli, Enterobacterium, and Clostridium. This complex bacterial diversity has led humans to be considered a superorganism, possessing approximately 300 times the number of genes of human cells and approximately 100 times the metabolic capacity of the human liver. [4]

[0003] The gut microbiome is considered an (endocrine) "super organ" [5] or "second brain" [6]. It is a complex microbial ecosystem in which bacteria coexist, communicate, exchange metabolic products, and recombine. This complex bacterial-gut interaction is strongly influenced by nutrition. Depending on the composition of the food and the bacteria, a variety of different bioactive metabolites are formed within the microbiome.

[0004] A prerequisite for healthy vitality is the equilibrium of bacterial cultures in the microbiome (eubiosis). This requires that the microbiome be supplied with a balanced mixture of the three macronutrients: carbohydrates, proteins, and fats. [7] The microbiome metabolizes indigestible nutrients such as complex glucans and glucoconjugates of plant cell walls (colloquially referred to as dietary fiber or fiber), proteins, glycine, taurine, bile acids, and other conjugates (i.e., products formed by the covalent bonding of at least two molecules). Anaerobic saccharolytic fermentation of fiber results in the production of "short-chain fatty acids (SCFAs)"—namely, acetate, propionate, and butyrate—via pyruvate.

[0005] Disturbances in the bacterial composition of the microbiome have a significant impact on vitality. Over 90% of all diseases and disorders are caused by dysbiosis. Notable examples include chronic intestinal inflammation, obesity, diabetes, acne, arteriosclerosis, asthma, neurodegenerative diseases, and certain types of cancer.[8] Dysbiosis can be caused by inadequate or inadequate nutrition, medications (especially antibiotics), and chronic stress.

[0006] Known metabolites of the gut microbiome include serotonin, short-chain fatty acids, various B vitamins (B1, B2, B5, B7, B9, B12), vitamin K, secondary bile acids, and branched-chain amino acids. Functionally, these metabolites improve nutrient metabolism and regulate the cardiovascular, immune, and nervous systems via the gut-brain axis [9], gut-lung axis

[10] , gut-heart axis

[11] , and gut-skin axis

[12] .

[0007] Carbohydrates, proteins and fats make up about 90% of the food's dry weight and 100% of its energy.

[0008] Various strains of lactic acid bacteria from the genus Bifidobacterium also have detoxifying properties. Lactic acid bacteria derived from Enterococcus faecalis strains may also have detoxifying and health-promoting properties. They cause the breakdown of oxalate, thereby preventing the formation of kidney stones.

[13]

[0009] Lactobacillus bacteria are heterofermentative lactic acid bacteria that ferment fiber to acetic and lactic acids via the phosphoketolase pathway. They are the most common bacterial genera in the microbiome

[14] .

[0010] Bifidobacterium, a member of the microbiome, is known to ferment the widest variety of fibers.

[15] From fiber fermentation, hexoses are synthesized into acetate and lactate in a 3:2 ratio. Acetate is a "short-chain fatty acid" that is involved in regulating metabolism as well as the immune and nervous systems.

[0011] Lactate is used for energy production (gluconeogenesis) and has many vascular effects. Short-chain fatty acids serve as an energy source for intestinal epithelial cells and are important signaling molecules. They bind to GPR41 and GPR43 receptors on epithelial cells and immune cells. These receptors regulate the release of proinflammatory cytokines, which act directly on the central nervous system via GLP1 (glucagon-like peptide 1) and PYY (peptide-tyrosine-tyrosine). Furthermore, short-chain fatty acids inhibit histone deacetylases (HDACs) in immune cells and adipocytes, thereby affecting their transcription. In this way, metabolism is regulated along with the immune and nervous systems.

[0012] With the help of transporter proteins, short-chain fatty acids are distributed throughout human tissues, including the brain.

[16] There, they regulate metabolism as well as the immune and nervous systems. Furthermore, they lower the pH to 5.5, thereby preventing the growth of pathogenic intestinal bacteria.

[0013] Enzymes in gut bacteria metabolize bile acid conjugates to secondary bile acids, which emulsify dietary fats and subsequently enable enzymatic lipolysis by lipases.

[0014] Enzymes in gut bacteria hydrolyze proteins into short peptides and individual amino acids, which are used to build and regenerate the intestinal mucosa and are transported via the bloodstream to cells where they are used in protein biosynthesis. Summary of the Invention [Problem to be solved by the invention]

[0015] The incidence of diseases due to disorders of the cardiovascular, immune and nervous systems is increasing in Western civilization. This increase is correlated with a decrease in dietary fiber consumption. A causal relationship exists between nutrition, dietary fiber intake and its metabolic products formed by fermentation, such as short-chain fatty acids.

[0016] Therefore, nutrition and the resulting changes in the composition of the microbiome are directly linked to the ills of Western civilization, such as digestive disorders, obesity, attention deficit, impaired concentration, and sleep disorders, which can be prevented or corrected by specially formulated probiotic food supplements.

[0017] Prebiotic intake influences the relative proliferation of bacterial strains, thereby altering the bacterial composition of the microbiome and, in turn, the composition of bioactive metabolites. [Means for solving the problem]

[0018] Taking all these scientific findings into account, the object of the present invention is to provide a beverage for building, promoting and maintaining intestinal health, which can be taken daily as part of a drinking regimen and which is characterized by being particularly effective and easy to use. The ingredients selected for this beverage are of great importance. DETAILED DESCRIPTION OF THE INVENTION

[0019] To this end, a beverage for building, promoting and maintaining the intestinal microbiome (eubiosis) is provided, which comprises at least the following ingredients: a probiotic containing approximately 30 billion live lactic acid bacteria per approximately 10 mL and at least 10 natural herbs and spices, which are preserved by fermentation by mixing the herbs and bacteria with water and sugarcane molasses, so that the bacteria consume the sugars in the molasses and convert them into lactic acid and acetic acid; Prebiotics combined with essential vitamins, minerals and trace elements, Natural nutritional oils containing more than 50% by weight of omega-3 fatty acids and tocopherols, These ingredients are processed into an emulsion as a beverage and administered preferably daily as part of a drinking therapy to build, promote and maintain the intestinal microbiome (eubiosis).

[0020] Daily consumption of this beverage as part of a drinking regimen supports the establishment, promotion, and maintenance of intestinal health. The first component contains approximately 30 billion live lactic acid bacteria per approximately 10 mL, as well as more than 10 natural herbs and spices. Optionally, the probiotics may also contain bacteria from Enterococcus faecium strains and one or more strains of the Lactobacillus and Bifidobacterium genera. These strains include, for example, the following strains from Denmark: JPEG2026503122000001.jpg90168 The product is naturally preserved by combining herbs and bacteria with water and sugarcane molasses and allowing it to ferment, during which the bacteria consume the sugars in the molasses and convert them into lactic acid and short-chain fatty acids.

[0021] The second component contains more than 10 types of plant fiber as a prebiotic substrate, as well as more than 30 types of minerals, vitamins, and trace elements. More than 25% by weight of the main component is plant fiber composed of complex glycans such as glucomannan, arabinogalactan, xyloglucan, galacturonan, fructooligosaccharides, or galactomannan. Galactomannans have a β-1,4-linked mannose backbone, to which α-1,6 galactose residues are partially linked. For example, guar gum contains this glycan.

[0022] Clinical trials have shown that dietary supplements enriched with partially hydrolyzed guar gum achieve beneficial clinical effects in reducing diarrhea, treating irritable bowel syndrome, and improving constipation.

[17] Additionally, the availability of fat and cholesterol for absorption is significantly reduced, reducing the risk of vascular disease.

[18]

[0023] The prebiotic substrates contained in the second component are metabolized by saccharolytic fermentative bacteria within the microbiome to lactic acid and the short-chain fatty acids acetate, propionate, and butyrate.

[0024] The purpose of the second component is to provide the microbiome with substrates that serve as precursors for the bacterial synthesis of short-chain fatty acids. Substrates that would produce toxic or harmful metabolites through bacterial synthesis are intentionally excluded from the second component.

[0025] The third ingredient is a natural nutritional oil highly enriched in omega-3s, such as flaxseed oil or sacha inchi nut oil. It contains more than 50% omega-3 fatty acids and up to 50 mg / 100 mL of tocopherol. Omega-3 fatty acids promote the increase of butyrate, a type of short-chain fatty acid-producing bacteria in the microbiome. In this way, omega-3 fatty acids prevent neurodegenerative diseases and protect against inflammation, arteriosclerosis, and heart attacks.

[19]

[0026] Research has shown that changes in the composition of the microbiome are causally linked to the development of so-called lifestyle-related diseases, which include previously unknown metabolic diseases such as obesity and diabetes, inflammatory bowel disease, asthma, allergies and immune disorders, and neurodegenerative diseases.

[20]

[0027] In these diseases, a significant decrease in bacterial diversity and the loss of specific metabolic functions are observed. The absence of specific bacteria, or dysbiosis, is the cause of the development of these complex diseases

[21] .

[0028] The simultaneous daily ritual consumption of a drinking regimen based on the proposed beverage with its three main components aims to ensure that the supplied substances are adapted to the daily circadian fluctuations in the composition and function of the microbiome

[22] .

[0029] The three ingredients, taken together as a daily ritual drinking regimen, combine probiotic and prebiotic foods, as well as dietary supplements, resulting in a unique synbiotic formulation.

[0030] References JPEG2026503122000002.jpg133166 JPEG2026503122000003.jpg239166 JPEG2026503122000004.jpg154166

Claims

1. A beverage for building, promoting and maintaining a gut microbiome (eubiosis), comprising at least a probiotic containing approximately 30 billion live lactic acid bacteria per 10 mL and at least 10 natural herbs and spices, which is preserved by fermentation by mixing the herbs and bacteria with water and sugarcane molasses, so that the bacteria consume the sugars in the molasses and convert them into lactic acid and acetic acid; - Prebiotics combined with essential vitamins, minerals and trace elements, natural nutritional oils containing more than 50% by weight of omega-3 fatty acids and tocopherols; It consists of the ingredients These ingredients are processed into an emulsion as a beverage and administered preferably daily as part of a drinking therapy to establish, promote and maintain the intestinal microbiome (eubiosis).

2. 2. The beverage according to claim 1, characterized in that the first component, the probiotic component, additionally contains live bacteria from an Enterococcus faecium strain and one or more strains of the genera Lactobacillus and Bifidobacterium.

3. The beverage according to claim 1 or 2, characterized in that the prebiotic component, which is the second component, contains more than 10 types of plant dietary fiber as a prebiotic substrate, and more than 30 different minerals, vitamins, and trace elements, and the main component contains more than 25% by weight of plant fiber derived from complex glycans such as glucomannan, arabinogalactan, xyloglucan, galacturonan, fructooligosaccharides, or galactomannan, and has a main chain of β-1,4-linked mannose and partially contains α-1,6-linked galactose residues.

4. 3. The beverage according to claim 1 or claim 2, characterized in that the second component, the prebiotic component, comprises more than 10 types of plant dietary fiber as prebiotic substrates and more than 30 different minerals, vitamins and trace elements, and the main component contains more than 25% by weight of fiber belonging to the glycan family, i.e., fiber derived from guar gum containing said fiber.

5. 5. The beverage according to claim 1, wherein the third component is a natural nutritional oil highly enriched in omega-3 fatty acids, such as flaxseed oil or sacha inchi nut oil, containing more than 50% of said omega-3 fatty acids and up to 50 mg / 100 mL of tocopherols.

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