Vitamin composition for use in cosmetic formulations

Abstract

The present invention relates to a vitamin composition comprising the following components: (a) Vitamins or their derivatives; (b) Lipid components; (c) Emulsifiers (optional); (d) solvent; and (e) Optionally, urea or a derivative thereof.

Description

Technical Field

[0001] The present invention relates to a vitamin composition, a method for producing the vitamin composition, various uses of the vitamin composition, and a cosmetic preparation containing the vitamin composition. The present invention also relates to the use of specific compounds for stabilizing vitamins.

Background Art

[0002] Vitamins are multifunctional substances commonly used in cosmetics. For example, they are used as antioxidants, anti-aging agents, skin whitening agents, and anti-inflammatory agents. For example, vitamins are used to strengthen the skin barrier or to protect the skin or hair from oxidative stress or damage (including UV-induced oxidative stress or damage).

[0003] There are two main groups of vitamins: fat-soluble vitamins and water-soluble vitamins. Fat-soluble vitamins include vitamins A, D, E, and K. Water-soluble vitamins include vitamin C and the vitamin B group.

[0004] Water-soluble vitamins are unstable under certain conditions and can be easily oxidized or decomposed by light, oxygen, high temperature, alkali, metal, and / or the level of pH, and / or interaction with specific raw materials contained in cosmetics. For example, ascorbic acid oxidizes immediately in an aqueous solution. For example, niacinamide hydrolyzes at a low pH value. It is still difficult to maintain the stability of vitamin B containing vitamin C and niacinamide in an aqueous solution.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] There remains a high demand for vitamin delivery systems that can be used in cosmetics. In particular, there is a need for stable vitamin delivery systems that, when incorporated into cosmetics, provide a consistent vitamin content. Specifically, there is a need for vitamin delivery systems that are stable in aqueous solutions. [Means for solving the problem]

[0007] It has been found that certain combinations of components can be used to stabilize vitamins or their derivatives. Therefore, the present invention relates to a vitamin composition comprising the following components: (a) a vitamin or its derivative; (b) a lipid component; (c) optionally an emulsifier; (d) a solvent; and (e) optionally a urea or its derivative.

[0008] In a preferred embodiment, the vitamin composition further comprises water.

[0009] The vitamin composition according to the present invention has the advantage of particularly excellent storage stability. This vitamin composition can be incorporated into cosmetic formulations, such as skin serums. By incorporating this vitamin composition into cosmetic formulations, it is possible to obtain a cosmetic composition that maintains a stable vitamin content even at relatively low pH levels.

[0010] The vitamin composition according to the present invention has the advantage of exhibiting a slower sustained-release profile, which is useful in a variety of applications, such as those in which the vitamins penetrate the surface and / or interior of the skin or hair over time. The vitamin composition according to the present invention has the advantages of being easy to prepare, easy to handle, and easy to use in cosmetic formulations.

[0011] The vitamin composition according to the present invention comprises (a) a vitamin or a derivative thereof. The vitamin is preferably selected from vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, and mixtures thereof. More preferably, the vitamin is selected from vitamin B, vitamin C, and mixtures thereof. Particularly preferably, the vitamin is vitamin B. Particularly preferably, the vitamin is vitamin C.

[0012] In preferred embodiments, the vitamin or its derivative is selected from ascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, tetrahexyldecyl ascorbate, ethylated ascorbic acid, 3-O-glycosyl ascorbic acid, 2-glucoside of ascorbic acid, and mixtures thereof.

[0013] In preferred embodiments, the vitamin or its derivative is selected from niacin (nicotinic acid), niacinamide (nicotinamide), nicotinamide mononucleotide, nicotinamide riboside, dihydronicotinic acid riboside, 1-methylnicotinamide, inositol hexaniacinate, and mixtures thereof.

[0014] In preferred embodiments, the vitamin or its derivative is selected from ascorbic acid, niacinamide, and mixtures thereof. In particularly preferred embodiments, the vitamin or its derivative is ascorbic acid. In particularly preferred embodiments, the vitamin or its derivative is niacinamide.

[0015] In preferred embodiments, the vitamin is selected from ascorbic acid, niacinamide, and mixtures thereof. In particularly preferred embodiments, the vitamin is ascorbic acid. In particularly preferred embodiments, the vitamin is niacinamide.

[0016] The vitamin composition according to the present invention comprises (b) a lipid component. Preferably, the lipid component is selected from lipids, phospholipids, and mixtures thereof. More preferably, the lipid component is selected from phospholipids.

[0017] The lipid is preferably selected from fatty acid esters. More preferably, the lipid is selected from triglycerides of one or more fatty acids, esters of one or more fatty acids and one or more fatty alcohols, and mixtures thereof. Even more preferably, the lipid is selected from triglycerides of one or more fatty acids having 8 to 24 carbon atoms, esters of one or more fatty acids having 8 to 24 carbon atoms and one or more fatty alcohols having 8 to 24 carbon atoms, and mixtures thereof.

[0018] The phospholipid is preferably selected from phosphatidic acid, phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidylinositol phosphate, phosphatidylinositol bisphosphate, phosphatidylinositol trisphosphate, ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide phosphoryl lipid, and mixtures thereof. Particularly preferred is phosphatidylcholine.

[0019] The vitamin composition according to the present invention optionally comprises (c) an emulsifier. In a preferred embodiment, the vitamin composition comprises an emulsifier. In a preferred embodiment, the emulsifier is selected from aliphatic alcohols, fatty acids, glyceryl esters, sorbitan esters, sorbitol esters, polyglyceryl esters, sucrose esters, phosphates, aliphatic alcohol ethoxylates, fatty acid ethoxylates, lactylates, and mixtures thereof.

[0020] In preferred embodiments, the emulsifier is selected from aliphatic alcohols having 8 to 22 carbon atoms, fatty acids having 8 to 22 carbon atoms, glycerol esters based on one or more C8-C22 fatty acids, sorbitan esters based on one or more C8-C22 fatty acids, sorbitol esters based on one or more C8-C22 fatty acids, polyglycerol esters based on one or more C8-C22 fatty acids, sucrose esters based on one or more C8-C22 fatty acids, phosphoric acid esters based on one or more C8-C22 aliphatic alcohols, phosphoric acid esters based on one or more ethoxylated C8-C22 aliphatic alcohols, C8-C22 aliphatic alcohol ethoxylates, C8-C22 fatty acid ethoxylates, lactic acid esters based on C8-C22 fatty acids, and mixtures thereof.

[0021] In a more preferred embodiment, the emulsifier is selected from aliphatic alcohols having 16 to 20 carbon atoms, fatty acids having 16 to 20 carbon atoms, glycerol esters based on one or more C16-C20 fatty acids, sorbitan esters based on one or more C16-C20 fatty acids, sorbitol esters based on one or more C16-C20 fatty acids, polyglycerol esters based on one or more C16-C20 fatty acids, sucrose esters based on one or more C16-C20 fatty acids, phosphoric acid esters based on one or more C16-C20 aliphatic alcohols, phosphoric acid esters based on one or more ethoxylated C16-C20 aliphatic alcohols, C16-C20 aliphatic alcohol ethoxylates, C16-C20 fatty acid ethoxylates, lactic acid esters based on C16-C20 fatty acids, and mixtures thereof.

[0022] In a particularly preferred embodiment, the emulsifier is selected from aliphatic alcohols having 16 to 18 carbon atoms, fatty acids having 16 to 18 carbon atoms, glycerol esters based on one or more C16-C18 fatty acids, sorbitan esters based on one or more C16-C18 fatty acids, sorbitol esters based on one or more C16-C18 fatty acids, polyglycerol esters based on one or more C16-C18 fatty acids, sucrose esters based on one or more C16-C18 fatty acids, phosphoric acid esters based on one or more C16-C18 aliphatic alcohols, phosphoric acid esters based on one or more ethoxylated C16-C18 aliphatic alcohols, C16-C18 aliphatic alcohol ethoxylates, C16-C18 fatty acid ethoxylates, lactic acid esters based on C16-C18 fatty acids, and mixtures thereof.

[0023] In a preferred embodiment, the emulsifier is selected from aliphatic alcohol ethoxylates, fatty acid ethoxylates, and mixtures thereof. In a more preferred embodiment, the emulsifier is selected from C8-C22 aliphatic alcohol ethoxylates, C8-C22 fatty acid ethoxylates, and mixtures thereof. In an even more preferred embodiment, the emulsifier is selected from C16-C20 aliphatic alcohol ethoxylates, C16-C20 fatty acid ethoxylates, and mixtures thereof. In a particularly preferred embodiment, the emulsifier is selected from C16-C18 aliphatic alcohol ethoxylates, C16-C18 fatty acid ethoxylates, and mixtures thereof.

[0024] The above aliphatic alcohol ethoxylate preferably contains, on average, 10 to 80, preferably 20 to 60, more preferably 30 to 50, and particularly preferably 35 to 45 ethylene oxy units per aliphatic alcohol unit.

[0025] The above fatty acid ethoxylate preferably contains, on average, 10 to 80, preferably 20 to 60, more preferably 30 to 50, and particularly preferably 35 to 45 ethylene oxy units per fatty acid unit.

[0026] In preferred embodiments, the emulsifier is selected from fatty acid ethoxylates.

[0027] In a more preferred embodiment, the emulsifier is selected from C8-C22 fatty acid ethoxylates. As used herein, C8-C22 refers to the number of carbon atoms in a fatty acid unit. Preferably, the C8-C22 fatty acid ethoxylate contains, on average, 10-80, preferably 20-60, more preferably 30-50, and particularly preferably 35-45 ethylene oxy units per fatty acid unit.

[0028] In a more preferred embodiment, the emulsifier is selected from C16-C20 fatty acid ethoxylates. As used herein, C16-C20 refers to the number of carbon atoms in a fatty acid unit. Preferably, the C16-C20 fatty acid ethoxylate contains, on average, 10-80, preferably 20-60, more preferably 30-50, and particularly preferably 35-45 ethylene oxy units per fatty acid unit.

[0029] In a particularly preferred embodiment, the emulsifier is selected from C16-C18 fatty acid ethoxylates. As used herein, C16-C18 refers to the number of carbon atoms in a fatty acid unit. Preferably, the C16-C18 fatty acid ethoxylate contains, on average, 10-80, preferably 20-60, more preferably 30-50, and particularly preferably 35-45 ethylene oxy units per fatty acid unit.

[0030] Particularly preferred is the emulsifier to be PEG-40 stearate, which is also referred to herein as PEG-40 monostearate.

[0031] The vitamin composition according to the present invention comprises (d) a solvent. In a preferred embodiment, the solvent is selected from propylene glycol (1,2-propanediol), 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, dipropylene glycol, ethylene glycol, polyethylene glycol, sorbitol, glycerin, and mixtures thereof. In a more preferred embodiment, the solvent is selected from propylene glycol, 1,3-propanediol, and mixtures thereof. In a particularly preferred embodiment, the solvent is propylene glycol.

[0032] The vitamin composition according to the present invention optionally includes (e) urea or a derivative thereof. In a preferred embodiment, the vitamin composition includes urea or a derivative thereof.

[0033] In preferred embodiments, the urea derivative is selected from 2-hydroxyethyl urea, 2-hydroxymethyl urea, bis(hydroxyethyl)urea, bis(hydroxymethyl)urea, N-(2-hydroxyethyl)ethylene urea, and mixtures thereof. In more preferred embodiments, the urea derivative is selected from 2-hydroxyethyl urea, 2-hydroxymethyl urea, and mixtures thereof. In particularly preferred embodiments, the urea derivative is 2-hydroxyethyl urea. As used herein, the term "urea derivative" refers to a derivative of urea.

[0034] The vitamin composition according to the present invention optionally further comprises (f) water. Preferably, the vitamin composition comprises water. In another embodiment, the vitamin composition does not contain water.

[0035] In preferred embodiments, the vitamin composition according to the present invention comprises the following components: (a) a vitamin or derivative thereof; (b) a lipid component; (c) an emulsifier; (d) a solvent; and (e) optionally a urea or derivative thereof.

[0036] In preferred embodiments, the vitamin composition according to the present invention comprises the following components: (a) a vitamin or derivative thereof; (b) a lipid component; (c) optionally an emulsifier; (d) a solvent; and (e) a urea or derivative thereof.

[0037] In preferred embodiments, the vitamin composition according to the present invention comprises the following components: (a) a vitamin or derivative thereof; (b) a lipid component; (c) an emulsifier; (d) a solvent; and (e) a urea or derivative thereof.

[0038] In preferred embodiments, the vitamin or its derivative is present in the vitamin composition in an amount of 1 to 40% by weight, preferably 5 to 30% by weight, more preferably 7 to 25% by weight, even more preferably 8 to 20% by weight, and particularly preferably 8 to 15% by weight, for example, 8 to 12% by weight, based on the total weight of the vitamin composition.

[0039] In preferred embodiments, the lipid component is present in the vitamin composition in an amount of 0.5 to 25% by weight, preferably 1 to 20% by weight, more preferably 1.5 to 15% by weight, even more preferably 1.5 to 12% by weight, and particularly preferably 1.5 to 5% by weight, for example, 2 to 3% by weight, based on the total weight of the vitamin composition.

[0040] In a preferred embodiment, the emulsifier is present in the vitamin composition in an amount of 3 to 30% by weight, preferably 5 to 25% by weight, more preferably 6 to 20% by weight, even more preferably 7 to 17% by weight, and particularly preferably 10 to 15% by weight, for example, 12 to 14% by weight, based on the total weight of the vitamin composition.

[0041] In a preferred embodiment, the emulsifier is present in the vitamin composition in an amount of 0 to 30% by weight, preferably 0 to 25% by weight, more preferably 0 to 20% by weight, even more preferably 0 to 17% by weight, and particularly preferably 0 to 15% by weight, based on the total weight of the vitamin composition.

[0042] In a preferred embodiment, the solvent is present in the vitamin composition in an amount of 4 to 30% by weight, preferably 6 to 25% by weight, more preferably 7 to 20% by weight, even more preferably 8 to 17% by weight, and particularly preferably 10 to 15% by weight, based on the total weight of the vitamin composition.

[0043] In preferred embodiments, urea or its derivatives are present in the vitamin composition in an amount of 3 to 30% by weight, preferably 5 to 25% by weight, more preferably 6 to 20% by weight, even more preferably 7 to 18% by weight, and particularly preferably 10 to 15% by weight, based on the total weight of the vitamin composition.

[0044] In preferred embodiments, urea or its derivatives are present in the vitamin composition in an amount of 0 to 30% by weight, preferably 0 to 25% by weight, more preferably 0 to 20% by weight, even more preferably 0 to 18% by weight, and particularly preferably 0 to 15% by weight, based on the total weight of the vitamin composition.

[0045] In a preferred embodiment, water is present in the vitamin composition in an amount of 20-70% by weight, preferably 25-60% by weight, more preferably 30-55% by weight, even more preferably 35-52% by weight, and particularly preferably 40-50% by weight, based on the total weight of the vitamin composition.

[0046] In a preferred embodiment, water is present in the vitamin composition in an amount of 0 to 70% by weight, preferably 0 to 60% by weight, more preferably 0 to 55% by weight, even more preferably 0 to 52% by weight, and particularly preferably 0 to 50% by weight, based on the total weight of the vitamin composition.

[0047] In preferred embodiments, the weight ratio of (a) vitamin or its derivative to (b) lipid component is 20:1 to 1:4, preferably 15:1 to 1:2, more preferably 10:1 to 1:1.5, and particularly preferably 6:1 to 3:1, for example 5:1 to 3.5:1.

[0048] In preferred embodiments, the weight ratio of (a) vitamin or its derivative to (c) emulsifier is 5:1 to 1:5, preferably 4:1 to 1:3, more preferably 3:1 to 1:2, and particularly preferably 1:1 to 1:2, for example, 1:1.0 to 1:1.5.

[0049] In preferred embodiments, the weight ratio of (a) vitamin or its derivative to (d) solvent is 5:1 to 1:5, preferably 3:1 to 1:3, more preferably 2:1 to 1:2, and particularly preferably 1:1 to 1:2, for example, 1:1.0 to 1:1.5.

[0050] In a preferred embodiment, the weight ratio of (a) vitamin or its derivative to (e) urea or its derivative is 5:1 to 1:5, preferably 4:1 to 1:3, more preferably 3:1 to 1:2, and particularly preferably 1:1 to 1:2, for example, 1:1.0 to 1:1.5.

[0051] In a preferred embodiment, the weight ratio of (a) vitamin or derivative to (f) water is 1:1 to 1:20, preferably 1:1 to 1:10, more preferably 1:2 to 1:6, and particularly preferably 1:3 to 1:5, for example, 1:4 to 1:5.

[0052] Furthermore, the present invention also relates to a method for producing the vitamin composition according to the present invention, and the production method is as follows: i) the step of preparing a mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative; and ii) optionally includes the step of adding water to the mixture obtained in step i).

[0053] Step i): The manufacturing method according to the present invention includes the step of preparing a mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative.

[0054] Preferred vitamins or their derivatives are as described above. Preferred lipid components are as described above. Preferred emulsifiers are as described above. Preferred solvents are as described above. Preferred urea derivatives are as described above.

[0055] Preferably, the mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative is prepared at a temperature of 20 to 150°C, more preferably 50 to 120°C, even more preferably 60 to 100°C, and particularly preferably 70 to 95°C, for example, in the range of 75 to 90°C.

[0056] Preferably, the mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative is subsequently cooled to a temperature of 0 to 70°C, more preferably 10 to 60°C, even more preferably 15 to 50°C, and particularly preferably 20 to 45°C, for example, in the range of 20 to 25°C or 40 to 50°C.

[0057] Preferably, the mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative is prepared at a pressure in the range of 400 mbar to 400 bar, more preferably 600 mbar to 2 bar, even more preferably 800 to 1200 mbar, and particularly preferably 1003 to 1023 mbar, for example, at a pressure of 1013 mbar.

[0058] Preferably, the mixture, comprising vitamins or their derivatives, lipid components, optionally an emulsifier, a solvent, and optionally urea or its derivatives, is prepared by stirring. Any stirrer can be used; for example, an overhead stirrer can be used.

[0059] Step i) of the method of the present invention can be carried out, for example, in a batch, semi-batch, semi-continuous, or continuous manner.

[0060] Step ii): Optionally, the manufacturing method according to the present invention includes the step of adding water to the mixture obtained in step i). In a preferred embodiment, the manufacturing method according to the present invention includes the step of adding water to the mixture obtained in step i).

[0061] Preferably, water is added to the mixture obtained in step i) at a temperature of 0 to 90°C, more preferably 10 to 60°C, even more preferably 15 to 50°C, and particularly preferably 20 to 45°C, for example, 20 to 25°C or 40 to 50°C.

[0062] Preferably, water is added to the mixture obtained in step i) at a pressure of 400 mbar to 400 bar, more preferably 600 mbar to 2 bar, even more preferably 800 to 1200 mbar, and particularly preferably 1003 to 1023 mbar, for example 1013 mbar.

[0063] Preferably, water is added to the mixture obtained in step i) while stirring. A stirrer may be used optionally. For example, an overhead stirrer can be used.

[0064] Step ii) of the method of the present invention can be carried out, for example, in a batch, semi-batch, semi-continuous, or continuous manner.

[0065] The method of the present invention can be carried out, for example, in a batch, semi-batch, semi-continuous, or continuous manner.

[0066] In a preferred embodiment, the vitamin composition of the present invention is obtained by the method of the present invention.

[0067] The present invention also relates to a vitamin composition obtained by the method of the present invention.

[0068] The present invention also relates to the use of a mixture comprising a lipid component, optionally an emulsifier, a solvent, optionally urea or a derivative thereof, and optionally water, for stabilizing a vitamin or a derivative thereof, or for improving the bioavailability of a vitamin or a derivative thereof.

[0069] In preferred embodiments, a mixture comprising a lipid component, optionally an emulsifier, a solvent, optionally urea or a derivative thereof, and optionally water is used to stabilize the vitamin or its derivative.

[0070] In preferred embodiments, a mixture comprising a lipid component, optionally an emulsifier, a solvent, optionally urea or a derivative thereof, and optionally water is used to improve the bioavailability of the vitamin or its derivative.

[0071] In preferred embodiments, a mixture comprising a lipid component, optionally an emulsifier, a solvent, optionally urea or a derivative thereof, and optionally water is used to stabilize the vitamin or its derivative and to improve the bioavailability of the vitamin or its derivative.

[0072] Preferred lipid components are as described above. Preferred emulsifiers are as described above. Preferred solvents are as described above. Preferred urea derivatives are as described above. Preferred vitamins or their derivatives are as described above.

[0073] The present invention also relates to the use of vitamin compositions as antioxidants, anti-aging agents, anti-wrinkle agents, skin whitening agents, skin brightening agents, depigmenting agents, anti-inflammatory agents, or anti-acne agents.

[0074] The present invention also relates to the use of vitamin compositions as antioxidants, anti-aging agents, anti-wrinkle agents, skin whitening agents, skin brightening agents, or depigmenting agents.

[0075] The present invention also relates to the use of vitamin compositions as anti-aging agents, anti-wrinkle agents, skin whitening agents, skin brightening agents, or depigmenting agents.

[0076] The present invention also relates to vitamin compositions for use as antioxidants, anti-aging agents, anti-wrinkle agents, skin whitening agents, skin brightening agents, depigmenting agents, anti-inflammatory agents, or anti-acne agents.

[0077] The present invention also relates to vitamin compositions for use as antioxidants, anti-inflammatory agents, or anti-acne agents.

[0078] The present invention also relates to a vitamin composition for use as an anti-inflammatory agent or an anti-acne agent.

[0079] The present invention also relates to the use of vitamin compositions for strengthening the skin barrier, protecting the skin or hair from oxidative stress or damage (including UV-induced oxidative stress or damage), protecting the skin or hair from photoaging, protecting the skin from UV-induced immunosuppression, protecting the skin from UV-induced carcinogenesis, promoting keratinocyte differentiation, inducing collagen synthesis, or inhibiting melanin production.

[0080] The present invention also relates to the use of vitamin compositions for strengthening the skin barrier, protecting hair from oxidative stress or damage (including UV-induced oxidative stress or damage), protecting skin or hair from photoaging, promoting keratinocyte differentiation, inducing collagen synthesis, or inhibiting melanin production.

[0081] The present invention also relates to the use of vitamin compositions to promote keratinocyte differentiation and induce collagen synthesis in order to protect the skin or hair from photoaging.

[0082] The present invention relates to a vitamin composition for use in order to strengthen the skin barrier, to protect the skin or hair from oxidative stress or damage (including UV-induced oxidative stress or damage), to protect the skin or hair from photoaging, to protect the skin from UV-induced immunosuppression, to protect the skin from UV-induced carcinogenesis, to promote keratinocyte differentiation, to induce collagen synthesis, or to inhibit melanin production.

[0083] The present invention relates to a vitamin composition for use in strengthening the skin barrier, protecting skin or hair from oxidative stress or damage (including UV-induced oxidative stress or damage), protecting skin from UV-induced immunosuppression, protecting skin from UV-induced carcinogenesis, or inhibiting melanin production.

[0084] The present invention relates to a vitamin composition for use in protecting the skin from oxidative stress or damage (including UV-induced oxidative stress or damage), protecting the skin from UV-induced immunosuppression, or protecting the skin from UV-induced carcinogenesis.

[0085] The present invention also relates to the use of vitamin compositions in cosmetic formulations.

[0086] The present invention also relates to cosmetic formulations comprising the following components: (A) a vitamin composition according to the present invention, wherein the vitamin composition is present in the cosmetic formulation in an amount such that, based on the total weight of the cosmetic formulation, the vitamin or its derivative is 1 to 30% by weight, preferably 5 to 25% by weight, more preferably 6 to 20% by weight, even more preferably 7 to 15% by weight, and particularly preferably 8 to 12% by weight; and (B) one or more further components.

[0087] Cosmetic formulations preferably include skin oil, skincare cream, skincare lotion, ointment, skin conditioner, face spray, body spray, hand oil, shower bath, hair conditioner, shaving gel, shampoo, body wash, facial cleanser, face mask, bubble bath, intimate wash, bath oil, cleansing milk, micellar water, makeup remover, cleansing sheets, hair mask, perfume, liquid soap, shaving soap, shaving foam, cleansing foam, day cream, anti-aging cream, body milk, body lotion, body mousse, skin serum, face serum, hand serum, nail serum, eye cream, sunscreen lotion, sun cream, face cream, aftershave lotion, pre-shave cream, hair removal cream, whitening gel, self-tanning cream, acne treatment gel, mascara, foundation, primer, concealer, The following products are selected from the group consisting of blush, bronzer, blemish balm (BB) cream, eyeliner, night cream, eyebrow gel, highlighter, lip stain, hand sanitizer, hair oil, nail polish remover, conditioner, hair styling gel, hair styling cream, frizz prevention serum, scalp treatment, hair color, split end remover, deodorant, antiperspirant, baby cream, insect repellent, hand cream, sunscreen gel, foot cream, exfoliator, face scrub, body scrub, cellulite treatment, cuticle cream, lip balm, hair treatment, eyeshadow, bath salts, body mist, eau de toilette, mouthwash, toothpaste, lubricating gel, moisturizer, serum, lotion, aqua sorbet, skin gel, cream gel, styling mousse, lipstick, lip gloss, body oil, shower milk, illuminator, lip crayon, hairspray, combing cream, and sunscreen.

[0088] Cosmetic formulations are more preferably selected from the group consisting of skin oils, day creams, anti-aging creams, body milks, body lotions, body mousses, skin serums, face serums, hand serums, nail serums, eye creams, sunscreen lotions, sun creams, face creams, aftershave lotions, skin whitening gels, self-tanning creams, anti-acne gels, foundations, primers, concealers, blemish balm (BB) creams, night creams, eyebrow gels, hand sanitizers, skin conditioners, deodorants, antiperspirants, baby creams, insect repellents, hand creams, sunscreen gels, foot creams, exfoliants, face scrubs, body scrubs, cellulite treatments, nail cuticle creams, lip balms, body mists, eau de toilettes, lubricating gels, moisturizers, serums, toners, aqua sorbets, skin gels, cream gels, body oils, illuminators, and sunscreens.

[0089] Cosmetic formulations are more preferably selected from the group consisting of skin oils, day creams, anti-aging creams, body milks, body lotions, skin serums, face serums, hand serums, nail serums, eye creams, sunscreen lotions, face creams, night creams, baby creams, hand creams, foot creams, exfoliants, face scrubs, body scrubs, nail cuticle creams, lip balms, moisturizers, serums, toners, skin gels, cream gels, body oils, and sunscreens.

[0090] The cosmetic formulation is particularly preferably selected from the group consisting of skin serum, face serum, hand serum, and nail serum.

[0091] In preferred embodiments, the cosmetic formulation has a pH value in the range of 1.5 to 8, more preferably 2 to 6, even more preferably 2.5 to 4, and particularly preferably 3 to 3.5.

[0092] In at least one embodiment, the formulation comprises a solvent. In at least one embodiment, the formulation comprises a solvent, which comprises water and / or alcohol. The solvent is useful for providing the compound used in the present invention in liquid form. In at least one embodiment, the solvent is cosmetically acceptable. In at least one embodiment, the formulation comprises at least 10% by weight, preferably at least 20% by weight, more preferably at least 30% by weight, and even more preferably at least 50% by weight of water. Water is useful not only for economic reasons but also because it is acceptable as a cosmetic. Optionally, the formulation includes a water-miscible or water-soluble solvent such as a lower alkyl alcohol. In at least one embodiment, the formulation includes a C1-C5 alkyl monohydric alcohol, preferably a C2-C3 alkyl monohydric alcohol. Alcohols that can be included include lower monohydric or polyhydric alcohols having 1-4 carbon atoms, commonly used in cosmetic applications, preferably ethanol and isopropanol.

[0093] In a preferred embodiment, the formulation comprises a solvent selected from the group consisting of water, glycol, ethanol, and mixtures thereof. In a preferred embodiment, the formulation comprises water. In one embodiment, the formulation is an aqueous solution.

[0094] In preferred embodiments, the formulation comprises an aqueous, alcoholic, or aqueous alcoholic solvent, the aqueous, alcoholic, or aqueous alcoholic solvent comprising water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, isobutanol, butanol, butyl glycol, butyl diglycol, 1,2-pentanediol, dipropylene glycol, glycerol, or mixtures thereof; preferably, the aqueous, alcoholic, or aqueous alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2- The solvent comprises 2-propylene glycol, 1,3-propylene glycol, glycerol, or a mixture thereof; more preferably, the aqueous, alcoholic, or aqueous alcoholic solvent comprises water, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, or a mixture thereof; even more preferably, the aqueous, alcoholic, or aqueous alcoholic solvent consists of water alone or a mixture of water and alcohol, the alcohol being selected from the group consisting of isopropanol, 1,2-propylene glycol, and 1,3-propylene glycol.

[0095] In at least one embodiment, the formulation includes additives (hereinafter referred to as "auxiliaries") that are common in cosmetics, pharmaceuticals, and dermatology. In at least one embodiment, the auxiliaries are selected from the group consisting of oily substances, cationic polymers, film-forming agents, superfatting agents, stabilizers, active biocomponents, glycerol, preservatives, glossing agents, dyes and fragrances, solvents, opacifiers, functional acids, and protein derivatives (e.g., gelatin), collagen hydrolysates, natural or synthetic polypeptides, egg yolk, lecithin, lanolin and lanolin derivatives, aliphatic alcohols, silicones, deodorants, substances having keratolytic and keratoplastic properties, enzymes, and / or carriers / solvents.

[0096] In at least one embodiment, the formulation includes water-soluble vitamins and their derivatives, water-soluble amino acids and their salts and / or derivatives, viscosity modifiers, dyes, non-volatile solvents or diluents (water-soluble and water-insoluble), glazing agents, thickeners, foaming agents, surfactants or co-surfactants, lice repellents, pH adjusters, fragrances, preservatives, chelating agents, proteins, skin activators, sunscreens, UV absorbers, vitamins, caffeine, minoxidil, and combinations thereof. In at least one embodiment, the formulation includes vitamins and amino acids in amounts of 0% to 5% by weight of the total weight of the formulation.

[0097] In at least one embodiment, the formulation comprises an oily substance which is optionally a fatty substance that is liquid at room temperature (25°C). In at least one embodiment, the formulation comprises volatile or non-volatile, linear, branched or cyclic, optionally organically modified silicone oils; phenyl silicones; silicone resins and silicone gums; mineral oils such as paraffin oil or petrolatum oil; animal-derived oils such as perhydrosqualene and lanolin; plant-derived oils such as liquid triglycerides, e.g., sunflower oil, corn oil, soybean oil, rice oil, jojoba oil, babusscu oil, pumpkin oil, grapeseed oil, Sesame oil, walnut oil, apricot oil, macadamia oil, avocado oil, sweet almond oil, cardamine oil, castor oil, caprylic / capric triglycerides, olive oil, peanut oil, rapeseed oil, argan oil, abyssinian oil, and coconut oil; parcelin oil, isoparaffin, linear and / or branched fatty alcohols and fatty acid esters, synthetic oils such as garvet alcohol having 6 to 18 (preferably 8 to 10) carbon atoms; linear (C6-C 13 ) fatty acids and linear (C6~C 20 ) Esters with fatty alcohols; branched (C6~C 13 )Carboxylic acids and linear (C6~C) 20 ) Esters with fatty alcohols, linear (C6~C) 18) Esters of fatty acids with branched alcohols, especially 2-ethylhexanol; esters of linear and / or branched fatty acids with polyhydric alcohols (e.g., dimergol or trimergol, etc.) and / or garvet alcohols; (C6~C 10 ) Fatty acid-based triglycerides; esters such as dioctyl adipate and diisopropyl dimer dilinoleate; waxes such as propylene glycol / propylene glycol dicaprylate or beeswax, paraffin wax or microwax (alone or in combination with hydrophilic waxes such as cetyl stearyl alcohol); fluorinated and perfluorinated oils; fluorinated silicone oils; and oily substances selected from the group consisting of mixtures of the above compounds.

[0098] In at least one embodiment, the formulation comprises a cationic polymer. Suitable cationic polymers include those known as INCI designated "polyquaternium," particularly polyquaternium-31, polyquaternium-16, polyquaternium-24, polyquaternium-7, polyquaternium-22, polyquaternium-39, polyquaternium-28, polyquaternium-2, polyquaternium-10, polyquaternium-11, and also polyquaternium-37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar hydroxypropyltriammonium chloride, and also calcium alginate and ammonium alginate. Cationic cellulose derivatives; cationic starch; copolymers of diallylammonium salts and acrylamide; quaternized vinylpyrrolidone / vinylimidazole polymers; condensation products of polyglycols and amines; quaternized collagen polypeptides; quaternized wheat polypeptides; polyethyleneimines; cationic silicone polymers such as amidemethicone; copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; polyaminopolyamides and cationic chitin derivatives such as chitosan are also possible.

[0099] In at least one embodiment, the formulation includes a superfatting agent. Possible superfatting agents include, for example, polyethoxylated lanolin derivatives, lecithin derivatives, polyol fatty acid esters, monoglycerides, or fatty acid alkanolamides. The latter also function as foam stabilizers. Available humectants include, for example, isopropyl palmitate, glycerol, and / or sorbitol.

[0100] In at least one embodiment, the formulation includes a stabilizer. As the stabilizer, for example, metal salts of fatty acids such as magnesium stearate, aluminum, and / or zinc may be used.

[0101] In at least one embodiment, the formulation includes a care additive. The formulation can be mixed with conventional ceramides, pseudo-ceramides, cholesterol, cholesterol fatty acid esters, fatty acids, triglycerides, cerebrosides, phospholipids, panthenol, and similar substances as care additives.

[0102] In at least one embodiment, the formulation contains a preservative or a preservative system. Examples of suitable preservatives include benzyl alcohol, piroctone olamine, phenoxyethanol, parabens, pentanediol, benzoic acid / sodium benzoate, sorbic acid / potassium sorbate, caprylhydroxamic acid, or combinations thereof. Examples of suitable preservative-promoting ingredients include anisic acid, lactic acid, sorbitan caprylate, ethylhexylglycerin, methylheptylglycerin, caprylyl glycol, caprylyl glyceryl ether, octanediol, capryloyl / caproyl anhydrous methyl glucamide (Velsan® Flex), or combinations thereof. In at least one embodiment, the formulation contains at least one preservative in an amount of 0.01 to 5% by weight, particularly preferably 0.05 to 1% by weight.

[0103] In one embodiment, the formulation is cetyltrimethylammonium chloride, cetylpyridinium chloride, benzethonium chloride, diisobutylethoxyethyldimethylbenzylammonium chloride, sodium N-lauryl sarcosinate, sodium N-palmethylsarcosinate, lauroyl sarcosine, N-myristoylglycine, potassium-N-lauryl sarcosine, trimethylammonium chloride, sodium aluminum chlorohydroxylactic acid, triethyl citrate, tricetylmethylammonium chloride, 2,4,4'-trichloro-2'- Hydroxydiphenyl ether (triclosan), phenoxyethanol, 1,5-pentanediol, 1,6-hexanediol, 3,4,4'-trichlorocarbanilide (triclocarban), diaminoalkylamide, L-lysine hexadecylamide, heavy metal citrate salts, salicylates, piroctose, zinc salts, pyrithione and its heavy metal salts, zinc pyrithione, zinc phenol sulfate, farnesol, ketoconazole, oxiconazole, bifonazole, butoconazole, croconazole, clotri Mazole, Econazole, Enilconazole, Fenticonazole, Isoconazole, Miconazole, Sulconazole, Thioconazole, Fluconazole, Itraconazole, Terconazole, Naphthifine, Terbinafine, Selenidol, Methylchloroisothiazolinone, Methylisothiazolinone, Methyldibromoglutaronitrile, Piroctone Olamine (Octopirox®), AgCl, Chloroxylenol, Sodium diethylhexyl sulfosuccinate, Sodium benzoate, Phenoxyethanol The following are selected from the group consisting of benzoyl alcohol, benzyl alcohol, phenoxyisopropanol, parabens, such as butyl-, ethyl-, methyl-, and propylparabens and their salts, pentanediol, 1,2-octanediol, ethylhexylglycerin, benzyl alcohol, sorbic acid, benzoic acid, lactic acid, imidazolidinyl urea, diazolidinyl urea, dimethyloldimethylhydantoin (DMDMH), sodium salts of hydroxymethylglycinate, hydroxyethylglycine of sorbic acid, and combinations thereof.

[0104] In at least one embodiment, the preservative is selected from the group consisting of phenoxyethanol, benzylparaben, butylparaben, ethylparaben, isobutylparaben, isopropylparaben, methylparaben, propylparaben, iodide propynyl butylcarbamate, methyldibromoglutaronitrile, DMDM ​​hydantoin, and combinations thereof. In at least one embodiment, the formulation is substantially paraben-free.

[0105] In at least one embodiment, the formulation contains an antifungal substance. In at least one embodiment, the antifungal substance is selected from the group consisting of ketoconazole, oxiconazole, bifonazole, butoconazole, croconazole, clotrimazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sulconazole, thioconazole, fluconazole, itraconazole, terconazole, naphthifine and terbinafine, zinc pyrithione, octopirox, and combinations thereof. In at least one embodiment, the formulation contains a total amount of antifungal substance of 0.1 wt% to 1 wt% in the formulation. In at least one embodiment, the formulation contains pyridinethion anti-dandruff particles, for example, 1-hydroxy-2-pyridinethion salt is a very preferred particulate anti-dandruff agent. The concentration of pyridinethion anti-dandruff particles can range from 0.1 wt% to 4 wt%, preferably 0.1 wt% to 3 wt%, and more preferably 0.3 wt% to 2 wt%, by the total weight of the formulation. Preferred pyridinethion salts include heavy metals such as zinc, tin, cadmium, magnesium, aluminum, and zirconium, preferably zinc, more preferably zinc salts of 1-hydroxy-2-pyridinethion (known as "zinc pyridinethion" or "ZPT"), and more preferably those formed from 1-hydroxy-2-pyridinethion salts in the form of small plate-like particles. Salts formed from other cations such as sodium may also be suitable.

[0106] Functional acids are acidic substances used to impart clinical functionality to the skin or hair upon application. Suitable functional acids include alpha hydroxy acids, beta hydroxy acids, lactic acid, retinoic acid, and similar substances.

[0107] In at least one embodiment, the formulation includes an astringent. In at least one embodiment, the astringent is selected from the group consisting of magnesium oxide, aluminum oxide, titanium dioxide, zirconium dioxide, zinc oxide, oxide hydrate, aluminum oxide hydrate (boehmite), and hydroxides and chlorohydrates of calcium, magnesium, aluminum, titanium, zirconium, or zinc. In at least one embodiment, the formulation contains 0.001% to 10% by weight, or 0.01% to 9% by weight, or 0.05% to 8% by weight, or 0.1% to 5% by weight of the astringent.

[0108] In at least one embodiment, the formulation includes a deodorant. In at least one embodiment, the deodorant is selected from the group consisting of allantoin, bisabolol, and combinations thereof. In at least one embodiment, the formulation includes 0.001% to 10% by weight, or 0.01% to 9% by weight, or 0.05% to 8% by weight, or 0.1% to 5% by weight of the deodorant.

[0109] In at least one embodiment, the formulation comprises a sunscreen and / or UV filter. Suitable sunscreens and UV filters are disclosed on page 32, line 11 to the end of page 33 of Patent Document 1 (WO2013 / 017262A1). In at least one embodiment, the sunscreen and / or UV filter comprises 4-aminobenzoic acid, 3-(4'-trimethylammonium)-benzylideborane-2-one-methylsulfate, camphorbenzalkonium methosulfate, 3,3,5-trimethylcyclohexyl salicylate, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and Triethanolamine salt, 3,3'-(1,4-phenylenedimetine)-bis-(7,7-dimethyl-2-oxobicyclo[2.2.1]-heptane-1-methanesulfonic acid) and its salts, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 3-(4'-sulfo)-benzylidene-bornan-2-one and its salts, 2-cyanide-3,3-diphenyl-acrylic acid-(2-ethylhexyl ester), Polymer of N-[2(and 4)-(2-oxoborn-3-ylidenemethyl)benzyl]acrylamide, 2-ethylhexyl 4-methoxycinnamate, ethoxylated ethyl-4-amino-benzoate, isoamyl 4-methoxycinnamate, 2,4,6-tris-[p-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2 -Methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyloxy)-disiloxanyl)-propyl)phenol, 4,4'-[(6-[4-((1,1-dimethylethyl)-amino-carbonyl)phenylamino]-1,3,5-triazine-2,4-yl)diimino]bis-(2-ethylhexyl benzoate), 3-benzophenone, 4-benzophenone (acic), 3(4'-methylbenzylidene)-D,L-camphor, 3-benzylidene-camphor, 2-ethylhexyl salicylate, 2-ethylhexyl dimethylaminobenzoate, hydroxy-4-methoxybenzophenone-5 sulfonic acid and its sodium salt, 4-isopropylbenzyl salicylate, N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilium methyl sulfate, homosalate (INN), oxybenzone (INN), 2-phenyl Benzimidazole-5-sulfonic acid and its sodium, potassium, and triethanolamine salts, octylmethoxycinnamic acid, isopentyl-4-methoxycinnamic acid, isoamyl-p-methoxycinnamic acid, 2,4,6-trianilino-(p-carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine(octyltriazone)phenol, 2,2(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3- Tetramethyl-1-(trimethylsilyl)oxy)-disiloxanyl)propyl(drometrizoletrisiloxane)benzoic acid, 4,4-((6-(((1,1-dimethylethyl)amino)carbonyl)phenyl)amino)-1,3,5-triazine-2,4-diyl)diimino)bis,bis(2-ethylhexyl)ester)benzoic acid, 4,4-((6-(((1,1-dimethylethyl)amino)-carbonyl)phenyl)amino)-1,3,5-triazine-2 ,4-diyl)diimino)bis,bis(2-ethylhexyl)ester), 3-(4'-methylbenzylidene)-D,L-camphor (4-methylbenzylidene camphor), benzylidene camphor sulfonic acid, octocrylene, polyacrylamide methylbenzylidene camphor, 2-ethylhexyl salicylate (octyl salicylate), 4-dimethylaminobenzoate ethyl-2-hexyl ester (octyldimethyl PABA), PEG-25 PABA, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (5-benzophenone) and its sodium salt, 2,2'-methylene-bis-6-(2H-benzotriazole-2-yl)-4-(tetramethyl-butyl)-1,1,3,3-phenol, 2-2'-bis-(1,4-phenylene)1H-phenylbenzimidazole-4,Sodium salt of 6-disulfonic acid, (1,3,5)-triazine-2,4-bis((4-(2-ethylhexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl), 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, glyceryl octanoate, di-p-methoxycinnamic acid, p-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranoxy)propoxy-2-hydroxy Benzophenone, octyl salicylate, methyl-2,5-diisopropylcinnamic acid, cinoxate, dihydroxy-dimethoxybenzophenone, disodium salt of 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone, dihydroxybenzophenone, 1,3,4-dimethoxyphenyl-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl-dimethoxybenzylidene dioxoimidazolidinepropionate, methylene-bis-benztriazolyltetramethyl Butylbutylphenol, phenyldibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol-methoxyphenol-triazine, tetrahydroxybenzophenone, terephthalylidene dicamphor-sulfonic acid, 2,4,6-tris[4,2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, methyl-bis(trimethylsiloxy)silyl-isopentyltrimethoxycinnamate, amyl-p-dimethylaminobenzoate, amyl-p-dimethylaminobenzoate Selected from the group consisting of cinzoates, 2-ethylhexyl-p-dimethylaminobenzoate, isopropyl-p-methoxycinnamate / diisopropylcinnamate ester, 2-ethylhexyl-p-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and trihydrate, 2-hydroxy-4-methoxybenzophenone-5-sulfonate sodium salt, phenyl-benzimidazole sulfonic acid, and combinations thereof.

[0110] In at least one embodiment, the formulation comprises 0.001 wt% to 10 wt%, preferably 0.05 wt% to 5 wt%, more preferably 0.1 wt% to 3 wt%, and most preferably 0.05 wt% to 1 wt%, of a sunscreen and / or UV filter. In at least one embodiment, the formulation comprises a photoprotective substance in an amount of 0.01 to 10 wt%, or 0.1 to 5 wt%, more preferably 0.2 to 2 wt%. Preferred photoprotective substances include, in particular, all of the photoprotective substances specified in EP1084696A1, which is incorporated herein by reference. In preferred embodiments, the photoprotective substance is selected from the group consisting of 2-ethylhexyl 4-methoxy cinnamate, methyl methoxy cinnamate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, polyethoxylated p-aminobenzoates, and combinations thereof.

[0111] In at least one embodiment, the formulation includes an antioxidant. In at least one embodiment, the antioxidant is selected from the group consisting of amino acids, peptides, sugars, imidazoles, carotenoids, carotenes, chlorogenic acid, lipoic acid, thiols, thiol glycosyl esters, thiol N-acetyl esters, thiol methyl esters, thiol ethyl esters, thiol propyl esters, thiol amyl esters, thiol butyl esters, thiol lauryl esters, thiol palmitoyl esters, thiol oleyl esters, thiol linoleyl esters, thiol cholesteryl esters, thiol glyceryl esters, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid, metal chelating agents, hydroxy acids, fatty acids, folic acid, vitamin C, tocopherol, vitamin A, stilbene, derivatives thereof, and combinations thereof.

[0112] In at least one embodiment, the antioxidants include glycine, histidine, tyrosine, tryptophan, urocanic acid, D,L-carnosine, D-carnosine, L-carnosine, beta-carotene, alpha-carotene, lycopene, dihydrolipoic acid, aurothioglucose, propylthiouracil, thioredoxin, glutathione, cysteine, cystine, cystamine, butionine sulfoximine, homocysteine ​​sulfoximine, butionine sulfone, penta-, hexa-, heptatihonine sulfoximine, hydroxy fatty acids, palmitic acid, phytic acid, lacto The following substances are selected from the group consisting of ferrin, citric acid, lactic acid, malic acid, humic acid, bile acid, bilirubin, biliverdin, EDTA, EGTA, linoleic acid, linolenic acid, oleic acid, butylhydroxyanisole, trihydroxybutyrophenone, ubiquinone, ubiquinol, ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate, vitamin E acetate, vitamin A palmitate, carnosine, mannose, ZnO, ZnSO4, selenium methionine, stilbene, superoxide dismutase, and combinations thereof.

[0113] In at least one embodiment, the antioxidant is selected from the group consisting of vitamin A, vitamin A derivatives, vitamin E, vitamin E derivatives, and combinations thereof. In at least one embodiment, the formulation contains 0.001 wt% to 10 wt%, preferably 0.05 wt% to 5 wt%, particularly preferably 0.1 wt% to 3 wt%, and especially preferably 0.05 wt% to 1 wt% of the antioxidant.

[0114] In at least one embodiment, the formulation comprises a dye or pigment. In at least one embodiment, the formulation comprises at least one pigment. Suitable dyes and pigments are disclosed in the table on pages 36-43 of Patent Document 1 (WO2013 / 017262A1). These may be colored pigments that give a coloring effect to the product mass or hair, or they may be glossing pigments that give a glossing effect to the product mass or hair. The coloring or glossing effect on the hair is preferably temporary; that is, the effect lasts until the next shampoo and can be removed again by washing with a regular shampoo.

[0115] In at least one embodiment, the formulation contains a total amount of pigment of 0.01 wt% to 25 wt%, preferably 5 wt% to 15 wt%. In at least one embodiment, the particle size of the pigment is 1 micron to 200 microns, preferably 3 microns to 150 microns, more preferably 10 microns to 100 microns.

[0116] Pigments are colorants that are virtually insoluble in the application medium and may be inorganic or organic. Inorganic-organic mixed pigments are also possible. Inorganic pigments are preferred. The advantage of inorganic pigments is their excellent resistance to light, weather, and temperature. Inorganic pigments may be of natural origin. In at least one embodiment, the inorganic pigment is selected from the group consisting of chalk, ochre, amber, green earth, burnt sienna, graphite, and combinations thereof.

[0117] The pigment may be a white pigment such as titanium dioxide or zinc oxide, a black pigment such as black iron oxide, a colored pigment such as ultramarine or red iron oxide, a gloss pigment, a metallic effect pigment, a pearlescent pigment, and preferably a fluorescent or phosphorescent pigment in which at least one pigment is a colored non-white pigment.

[0118] In at least one embodiment, the pigment is selected from the group consisting of metal oxides, hydroxides and oxide hydrates, mixed-phase pigments, sulfur-containing silicates, metal sulfides, complex metal cyanide compounds, metal sulfates, chromates and molybdates, and metals themselves (bronze pigments), as well as combinations thereof.

[0119] In at least one embodiment, the pigment is selected from the group consisting of titanium dioxide (CI 77891), black iron oxide (CI 77499), yellow iron oxide (CI 77492), red and brown iron oxide (CI 77491), manganese violet (CI 77742), ultramarine (sodium aluminum sulfosilicate, CI 77007, Pigment Blue 29), chromium oxide hydrate (CI 77289), Prussian blue (iron ferrocyanide, CI 77510), carmine (cochineal), and combinations thereof.

[0120] In at least one embodiment, the pigment is selected from the group consisting of pearlescent and colored pigments based on mica coated with metal oxides or metal chlorides such as titanium dioxide or bismuth oxychloride, and optionally, further colorants such as iron oxide, Prussian blue, ultramarine, carmine, etc., whose color can be determined by varying the thickness of the layer. Such pigments are sold, for example, by Merck, Germany, under trade names Rona®, Colorona®, Dichrona® and Timiron®. In at least one embodiment, the pigment is selected from the group consisting of organic pigments such as sepia, gamboge, bone ash, Cassel brown, indigo, chlorophyll, and other plant pigments. In at least one embodiment, the pigment is selected from the group consisting of azo pigments, anthraquinoids, indigoids, dioxazine, quinacridone, phthalocyanine, isoindolinone, perylene and perinone, metal complexes, alkali blue, and synthetic organic pigments such as diketopyrrolopyrrole pigments.

[0121] In at least one embodiment, the formulation contains at least one particulate material in an amount of 0.01 wt% to 10 wt%, preferably 0.05 wt% to 5 wt%. Suitable materials are, for example, solid at room temperature (25°C) and particulate. In at least one embodiment, the particulate material is selected from the group consisting of suitable silica, silicates, aluminates, clay earth, mica, insoluble salts, particularly insoluble inorganic metal salts, metal oxides, such as titanium dioxide, minerals, and insoluble polymer particles.

[0122] The particles may be present in the formulation in an insoluble form, preferably in a stably dispersed form, and can be deposited on the keratin substrate in a solid form after application to the substrate and evaporation of the solvent. Stable dispersion can be achieved by providing the formulation with a yield point large enough to prevent the solid particles from settling. A suitable yield point can be established by using a suitable amount of a suitable gel-forming agent. In at least one embodiment, the particulate matter is selected from the group consisting of silica (silica gel, silicon dioxide) and metal salts, particularly inorganic metal salts, with silica being particularly preferred. The metal salts are, for example, alkali metal halides or alkaline earth metal halides such as sodium chloride or potassium chloride; alkali metal sulfates or alkaline earth metal sulfates such as sodium sulfate or magnesium sulfate.

[0123] In at least one embodiment, the formulation contains a direct dye. Preferred direct dyes are the following compounds, either alone or in combination: hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicramic acid, 4-nitrophenylaminourea, tri(4-amino-3-methylphenyl)carbenium chloride (Basic Violet 2), 1,4-di-amino-9,10-anthracendione (Disperse Violet 1), 1-(2-hydroxyethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Blue No. 12), 1-amino-4-[di(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No.3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No.10), 5-chloro-1,4-[di(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No.11), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No.13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonio)-phenyl]amino}-1(4H)-naphthalenone chloride (CI 56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (CI 12250; Basic Brown No. 16), 1-[(4-amino-2-nitrophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (Basic Brown No.17) 2-hydroxy-1-[(2-methoxyphenyl)azo]-7-(trimethylammonio)naphthalene chloride (CI 12245; Basic Red No. 76), 3-methyl-1-phenyl-4-{[3-(trimethylammonio)phenyl]azo}pyrazole-5-on chloride (CI 12719; Basic Yellow No. 57), and 2,6-diamino-3-[(pyridine-3-yl)azo]pyridine, and their salts.

[0124] Of the direct dyes mentioned above, the following compounds, either alone or in combination, are particularly preferred: hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicramic acid, 4-nitrophenylaminourea, tri(4-amino-3-methylphenyl)carbenium chloride (Basic Violet 2), 1,4-di-amino-9,10-anthracendione (Disperse Violet 1), 1-(2-hydroxy-ethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Blue No. 12), 1-amino-4-[di(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No.3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No.10), 5-chloro-1,4-[di(2,3-dihydroxypropyl)-amino]-2-nitrobenzene (HC Red No.11), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No.13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonio)-phenyl]amino}-1(4H)-naphthalenone chloride (CI56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (CI 12250; Basic Brown No. 16), 1-[(4-amino-2-nitrophenyl)azo]-7-(trimethylammonio)-2-naphthol chloride (Basic Brown No. 17), 2-hydroxy-1-[(2-methoxyphenyl)azo]-7-(trimethylammonio)naphthalene chloride (CI12245; Basic Red No. 76), 3-methyl-1-phenyl-4-{[3-(trimethylammonio)phenyl]azo}pyrazole-5-on chloride (CI 12719; Basic Yellow No. 57), and 2,6-di-amino-3-[(pyridine-3-yl)azo]pyridine, as well as their salts.

[0125] In at least one embodiment, the total amount of direct dye in the formulation is 0.01 to 15 wt%, preferably 0.1 to 10 wt%, and most preferably 0.5 to 8 wt%.

[0126] In at least one embodiment, the formulation includes a conditioning agent. In at least one embodiment, the conditioning agent is a water-insoluble, water-dispersible, non-volatile liquid that forms emulsified liquid particles. In at least one embodiment, the conditioning agent is a silicone (e.g., silicone oil, cationic silicone, silicone gum, high refractive index silicone, or silicone resin), an organic conditioning oil (e.g., hydrocarbon oil, polyolefin, or fatty ester), a cationic conditioning surfactant, a high melting point fatty compound, or a combination thereof.

[0127] In at least one embodiment, the conditioning agent is a silicone, and the formulation comprises 0.01% to 10%, or 0.1% to 5%, of the total weight of the formulation of the silicone conditioning agent. Suitable silicone conditioning agents and optional suspending agents for silicone are described in US5,104,646. In at least one embodiment, the formulation comprises a silicone gum selected from the group consisting of polydimethylsiloxane, (polydimethylsiloxane)(methylvinylsiloxane) copolymer, poly(dimethylsiloxane)(diphenylsiloxane)(methylvinylsiloxane) copolymer, and mixtures thereof.

[0128] In at least one embodiment, the formulation comprises a terminal amino silicone. As defined herein, "terminal amino silicone" means a silicone containing one or more amino groups at one or both ends of the silicone backbone. In at least one embodiment, the formulation substantially does not contain any silicone compounds containing pendant amino groups. In one embodiment, the formulation substantially does not contain any silicone compounds other than the terminal amino silicone. In at least one embodiment, the amino group at at least one end of the silicone backbone of the terminal amino silicone is selected from the group consisting of primary amines, secondary amines, and tertiary amines. In at least one embodiment, the formulation contains 0.1% to 20%, or 0.5% to 10%, or 1% to 6% of the terminal amino silicone based on the total weight of the formulation.

[0129] In at least one embodiment, the formulation comprises a cationic conditioning surfactant. In at least one embodiment, the formulation contains 0.05% to 3.0%, or 0.075% to 2.0%, or 0.1% to 1.0% of the cationic conditioning surfactant based on the total weight of the formulation. In at least one embodiment, the cationic conditioning surfactant is included in the lamellar gel matrix. In other words, the formulation contains a lamellar gel matrix, and the lamellar gel matrix contains a cationic conditioning surfactant. In one embodiment, the cationic conditioning surfactant is according to the following formula (C):

Chemical formula

[0130] In at least one embodiment, the cationic conditioning surfactant is selected from the group consisting of behenyltrimethylammonium chloride, methyl sulfate or ethyl sulfate, and stearyltrimethylammonium chloride, methyl sulfate or ethyl sulfate. Longer alkyl groups are thought to improve smoothness and softness of hair, both wet and dry, compared to cationic surfactants with shorter alkyl groups. Such cationic surfactants are also thought to be less irritating compared to those with shorter alkyl groups.

[0131] In at least one embodiment, the cationic surfactant is a dilong-chain alkyl quaternary ammonium salt selected from the group consisting of dialkyl(C14-C18)dimethylammonium chloride, ditallow alkyldimethylammonium chloride, dihydrogenated tallow alkyldimethylammonium chloride, distearyldimethylammonium chloride, dicetyldimethylammonium chloride, and mixtures thereof.

[0132] In at least one embodiment, the cationic surfactant is a tertiary amide amine having an alkyl group of 12 to 22 carbon atoms. The tertiary amide amine may be selected from the group consisting of stearamidopropyldimethyl-, stearamidopropyldiethyl-, stearamidoethyldiethyl-, stearamidoethyldimethyl-, palmitamidopropyldimethyl-, palmitamidopropyldiethyl-, palmitamidoethyldiethyl-, palmitamidoethyldimethyl-, behenamidopropyldimethyl-, behenamidopropyldiethyl-, behenamidoethyldiethyl-, behenamidoethyldimethyl-, arachidomidopropyldimethyl-, arachidomidopropyldiethyl-, arachidomidoethyldiethyl-, and arachidomidoethyldimethylamine, diethylaminoethylstearamide, and mixtures thereof. The tertiary amide amine can be used in combination with an acid. The acid is typically used as a salt-forming anion. In one embodiment, the acid is selected from the group consisting of lactic acid, malic acid, hydrochloric acid, 1-glutamic acid, acetic acid, citric acid, and mixtures thereof.

[0133] In at least one embodiment, the cationic surfactant is selected from the group consisting of cetyltrimonium chloride (CTAC), stearyltrimonium chloride (STAC), behentrimonium methosulfate, stearoylamidopropyldimethylamine (SAPDMA), distearyldimethylammonium chloride, and mixtures thereof.

[0134] In at least one embodiment, the formulation includes a surfactant system. In at least one embodiment, the surfactant system includes a surfactant selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and / or amphoteric surfactants. In at least one embodiment, the formulation includes a total amount of surfactant of 0.01 wt% to 70 wt%, 0.1 wt% to 40%, 1 wt% to 30%, and 2 wt% to 20 wt%.

[0135] In at least one embodiment, the formulation comprises an anionic surfactant. In at least one embodiment, the anionic surfactant is (C 10 ~C 20 The group consists of )-alkyl and alkylene carboxylates, alkyl ether carboxylates, fatty alcohol sulfates, fatty alcohol ether sulfates, alkylamide sulfates and sulfonates, fatty acid alkylamide polyglycol ether sulfates, alkanesulfonates and hydroxyalkanesulfonates, olefin sulfonates, isethionate acyl esters, α-sulfo fatty acid esters, alkylbenzene sulfonates, alkylphenol glycol ether sulfonates, sulfosuccinates, sulfosuccinate monoesters and diesters, fatty alcohol ether phosphates, protein / fatty acid condensation products, alkyl monoglyceride sulfates and sulfonates, alkylglyceride ether sulfonates, fatty acid methyl taurids, fatty acid sarcosinates, sulfolicinolates, acyl glutamates, and mixtures thereof. Anionic surfactants (and mixtures thereof) may be used in the form of their water-soluble or water-dispersible salts, e.g., sodium, potassium, magnesium, ammonium, mono, di-, and triethanolammonium, as well as similar alkylammonium salts. In at least one embodiment, the anionic surfactant is a salt of an anionic surfactant containing 12 to 14 carbon atoms. In at least one embodiment, the anionic surfactant is selected from the group consisting of sodium lauryl sulfate, sodium laureth sulfate, sodium tridecyl sulfate, sodium trideceth sulfate, sodium myristyl sulfate, sodium sodium myreth sulfate, and mixtures thereof.

[0136] In at least one embodiment, the formulation comprises an acylglycinate surfactant. In at least one embodiment, the acylglycinate surfactant conforms to the following formula (Y): [ka] (In the formula, R1a Q is a linear or branched saturated alkyl group having 6 to 30 carbon atoms, preferably 8 to 22, and particularly preferably 8 to 18 carbon atoms, or a linear or branched mono- or polyunsaturated alkenyl group having 6 to 30 carbon atoms, preferably 8 to 22, and particularly preferably 12 to 18 carbon atoms. a + (It is a cation).

[0137] In at least one embodiment, Q a + Li + kaNa + , K + Mg ++ Ca ++ , Al +++ NH4 + , selected from the group consisting of monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions and tetraalkylammonium ions, or combinations thereof. In at least one embodiment, the acylglycinate surfactant is selected from sodium cocoyl glycinate and potassium cocoyl glycinate. In at least one embodiment, the acylglycinate surfactant is of formula (Y) (wherein R is C 12 Alkyl or C 14 Selected from those conforming to the formula (Y)(R is C). In at least one embodiment, the acylglycinate surfactant is a surfactant of formula (Y)(R is C). 16 Alkyl or C 18 It is selected from those that conform to the condition (being alkyl).

[0138] In at least one embodiment, the formulation comprises a glutamate surfactant of the following formula (Z) or a salt thereof: [ka] (In the formula, R' is HOOC-CH2-CH2- or M +- OOC-CH2-CH2-, where M +( is a cation; R is a linear or branched saturated alkyl group having 6 to 30 carbon atoms, preferably 8 to 22, more preferably 8 to 18, or a linear or branched mono- or polyunsaturated alkenyl group having 6 to 30 carbon atoms, preferably 8 to 22, and more preferably 12 to 18).

[0139] In at least one embodiment, M + is a metal cation. In at least one embodiment, M + Li + na + , K + Mg ++ Ca ++ , Al +++ NH 4+ The group consists of monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions, and tetraalkylammonium ions, or combinations thereof.

[0140] In at least one embodiment, the glutamate surfactant is selected from sodium cocoyl glutamate and potassium cocoyl glutamate. In at least one embodiment, the glutamate surfactant is of formula (Z) (wherein R is C 12 Alkyl or C 14 Selected from those conforming to the formula (which is alkyl). In at least one embodiment, the glutamic acid surfactant is a surfactant of formula (Z) (wherein R is C 16 Alkyl or C 18 It is selected from those that conform to the condition (being alkyl).

[0141] In at least one embodiment, the formulation contains 0.01 wt% to 30 wt%, preferably 1 wt% to 25 wt%, more preferably 5 wt% to 20 wt%, and particularly preferably 12 wt% to 18 wt% of an anionic surfactant.

[0142] In at least one embodiment, the formulation comprises a nonionic surfactant. In at least one embodiment, the nonionic surfactant has an HLB (hydrophilic-lipophilic balance) greater than 12. Optionally, the nonionic surfactant is selected from the group consisting of ethoxylated or ethoxylated / propoxylated fatty alcohols having fatty chains with 12 to 22 carbon atoms, ethoxylated sterols such as stearyl- or lauryl alcohol (EO-7), PEG-16 soybean sterols or PEG-10 soybean sterols, polyoxyethylene polyoxypropylene block polymers (poloxamers), sorbitan esters, sorbitan ester ethoxylates, and mixtures thereof.

[0143] In at least one embodiment, the nonionic surfactant is an ethoxylated fatty alcohol, a fatty acid, a fatty acid glyceride, or an alkylphenol, particularly C8-C 22 C to fatty alcohols 12 ~C 22 Adducts of 2-30 mol of ethylene oxide and / or 1-5 mol of propylene oxide to fatty acids or alkylphenols having 8-15 carbon atoms in an alkyl group, and adducts of 1-30 mol of ethylene oxide to glycerol. 12 ~C 22 Fatty acid mono- and diesters, adducts of 5-60 mol of ethylene oxide to castor oil or hydrogenated castor oil, fatty acid sugar esters, especially sucrose and one or two C8-C2 22 Fatty acid esters, INCI: sucrose coconut fatty acid, sucrose dilaurate, sucrose distearate, sucrose laurate, sucrose myristate, sucrose oleate, sucrose palmitate, sucrose ricinoleate, sucrose stearate, sorbitan and 1, 2 or 3 C8-C 22 Fatty acids and esters with 4-20 degrees of ethoxylation, polyglyceryl fatty acid esters (especially 1, 2 or more C8-C) 22 Fatty acids and, preferably, polyglycerols having 2 to 20 glyceryl units, C8 to C 22The group consists of alkyl glucosides, alkyl oligoglucosides, and alkyl polyglucosides having an alkyl group, such as decyl glucoside or lauryl glucoside, and mixtures thereof.

[0144] In at least one embodiment, the nonionic surfactant is selected from the group consisting of fatty alcohol ethoxylates (alkyl polyethylene glycol), alkylphenol polyethylene glycol, alkyl mercaptan polyethylene glycol, fatty amine ethoxylates (alkylamino polyethylene glycol), fatty acid ethoxylates (acyl polyethylene glycol), polypropylene glycol ethoxylates (Pluronics®), fatty acid alkylolamides (fatty acid amide polyethylene glycol), N-alkyl fatty acid amides, N-alkoxy polyhydroxy fatty acid amides, sucrose esters, sorbitol esters, polyglycol ethers, and mixtures thereof.

[0145] In at least one embodiment, the formulation comprises a fatty acid N-methyl-N-glucamide surfactant, the fatty acid N-methyl-N-glucamide surfactant having the following formula (X): [ka] (In the formula, R is selected from saturated or unsaturated hydrocarbon chains having 5 to 23 carbon atoms.)

[0146] In formula (X), R is preferably selected from saturated or unsaturated hydrocarbon chains having 7 to 17 carbon atoms. Also preferably, the RC=O residue in formula (X) is derived from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, coconut fatty acids, or combinations thereof. Furthermore, the RC=O residue in formula (X) is preferably derived from 9-10-hydroxy-2-decenoic acid, 9-dodecenoic acid, or mixtures thereof.

[0147] Particularly preferred N-methyl-N-acylglucamines of formula (X) are capryloyl / caproylmethylglucamide, lauroyl / myristoylmethylglucamide, cocoylmethylglucamide, oleylmethylglucamide, or mixtures thereof. Such N-methyl-N-acylglucamines are commercially available from Clariant (GlucoTain® Clear, GlucoTain® Plus, GlucoTain® Flex, GlucoTain® Care, GlucoTain® Sense).

[0148] Furthermore, particularly preferred N-methyl-N-acylglucamines of formula (X) are N-9-decenoyl-N-methylglucamine, N-9-dodecenoyl-N-methylglucamine, or mixtures thereof.

[0149] In at least one embodiment, the formulation contains 1 wt% to 20 wt%, preferably 2 wt% to 10 wt%, and more preferably 3 wt% to 7 wt%, of a nonionic surfactant.

[0150] In at least one embodiment, the formulation comprises an amphoteric surfactant. In at least one embodiment, the amphoteric surfactant is an alkali metal salt and N-(C) as mono-, di-, and trialkylammonium salts. 12 ~C 18 )-alkyl-beta-aminopropionate and N-(C 12 ~C 18 )-alkyl-beta-iminodipropionate; N-acylaminoalkyl-N,N-dimethylacetobetaine, preferably N-(C8~C 18 )-Acylaminopropyl-N,N-dimethylacetobetaine, (C 12 ~C 18)-Alkyl-dimethyl-sulfopropyl betaine, amphoteric surfactants based on imidazoline (e.g., Miranol®, Steinapon®), preferably sodium salt of 1-(β-carboxymethyloxyethyl)-1-(carboxymethyl)-2-lauryl-imidazolinium; amine oxide, e.g., (C 12 ~C 18 Selected from the group consisting of )-alkyl-dimethylamine oxide, fatty acid amide alkyldimethylamine oxide, and mixtures thereof.

[0151] In at least one embodiment, the formulation contains a betaine surfactant. Optionally, the betaine surfactant is C8-C 18 The betaine surfactant is selected from alkyl betaines. In at least one embodiment, the betaine surfactant is selected from the group consisting of cocodimethylcarboxymethyl betaine, lauryldimethylcarboxymethyl betaine, lauryldimethylalphacarboxyethyl betaine, cetyldimethylcarboxymethyl betaine, oleyldimethylgammacarboxypropyl betaine, and laurylbis(2-hydroxypropyl)alphacarboxyethyl betaine, as well as combinations thereof.

[0152] Selectively, betaine surfactants are C8-C 18 Selected from sulfobetaines. In at least one embodiment, the betaine surfactant is selected from the group consisting of cocodimethylsulfopropyl betaine, stearyldimethylsulfopropyl betaine, lauryldimethylsulfoethyl betaine, laurylbis(2-hydroxyethyl)sulfopropyl betaine, and combinations thereof. Optionally, the betaine surfactant is a carboxyl derivative of imidazole, C8-C 18 Alkyldimethylammonium acetate, C8~C 18 Alkyldimethylcarbonylmethylammonium salts, and C8~C 18 Selected from fatty acid alkylamide betaines and mixtures thereof. Optionally, C8-C 18The fatty acid alkylamide betaine is selected from coconut fatty acid amidopropyl betaine, N-coconut fatty acid amidoethyl-N-[2-(carboxymethoxy)ethyl]glycerol (CTFA name: cocoamphocarboxyglycinate), and mixtures thereof.

[0153] In at least one embodiment, the formulation contains 0.5 wt% to 20 wt%, preferably 1 wt% to 10 wt%, of an amphoteric surfactant.

[0154] In at least one embodiment, the formulation comprises a surfactant system. In at least one embodiment, the surfactant system comprises at least one surfactant selected from the group consisting of lauryl sulfate, laureth sulfate, cocoamidopropyl betaine, sodium cocoyl glutamate, lauroamphoacetate, and mixtures thereof. In at least one embodiment, the surfactant system comprises sodium laureth sulfate, sodium lauryl sulfate, and optionally cocamidopropyl betaine. In at least one embodiment, the surfactant system comprises sodium laureth sulfate, potassium cocoyl glutamate, and cocamidopropyl betaine.

[0155] In at least one embodiment, the viscosity of the formulation at 25°C is 0.1 cPs to 20,000 cPs. In at least one embodiment, the viscosity of the formulation at 25°C is 0.1 cPs to 10,000 cPs, or 1 cPs to 5,000 cPs, or 5 cPs to 3,500 cPs. The conditions for measuring viscosity are defined in the definition section above. Viscosity may be important for the reason of preventing dripping. Dripping can be inconvenient for the user. Furthermore, more viscous formulations may be useful for metering and dispensing. In at least one embodiment, the viscosity of the formulation at 25°C is 0.1 cPs to 1,000 cPs. This viscosity range is advantageous in terms of the need for dispersion on the skin and the ability to wash away the product when the formulation is in the form of a facial cleanser.

[0156] In at least one embodiment, the formulation further comprises a viscosity modifier. The viscosity modifier is preferably a thickening polymer.

[0157] In at least one embodiment, the thickening polymer is a polymer based on acrylamide methylpropanesulfonic acid (AMPS®). These polymers exhibit good thickening performance even at pH values ​​of 7 or less. Particularly preferred, the thickening polymer is selected from the group consisting of homopolymers or copolymers of acrylamide methylpropanesulfonic acid and its salts. Of these polymers, preferred are polymers having at least 20 mol% of units based on acrylamide methylpropanesulfonic acid and / or its salts, and particularly preferred are polymers having at least 50 mol% of units based on acrylamide methylpropanesulfonic acid and / or its salts (molar quantities refer to the entire polymer in each case).

[0158] In addition to structural units based on acrylamide methylpropanesulfonic acid and / or its salts, in the case of copolymers, preferably one or more structural units based on the following comonomers are present in the copolymer: acrylic acid, methacrylic acid, acrylamide, dimethylacrylamide, vinylpyrrolidone (VP), hydroxyethyl acrylate, hydroxyethyl methacrylate, ethoxylated alcohol RO-(CH2CH2O) m H(where R is an alkyl group having 12 to 30 carbon atoms, m is a number from 3 to 30, and CH2=CH-COO-(CH2CH2-COO)) n X(where n is a number from 0 to 10, and X is a counterion, preferably H) + na + and / or NH4 + Acrylic ester or methacrylic ester (which is).

[0159] Polymers selected from the group consisting of acrylamide methylpropanesulfonic acid and its salts, homopolymers or copolymers, may be crosslinked or uncrosslinked. In the case of crosslinking, they contain structural units for monomers having two or more olefin double bonds. In the case of crosslinking, preferably 0.1 to 10 mol% of such structural units are present in the homopolymer or copolymer relative to the entire polymer.

[0160] One or more structural units of acrylamidemethylpropanesulfonic acid and / or its salts in a homopolymer or copolymer of acrylamidemethylpropanesulfonic acid and / or its salts are H + If there is one or more counterions other than Na, these other counterions are Na + and NH4 + Preferably selected from the group consisting of:

[0161] Suitable polymers are mentioned in publications including EP0816403, EP1069142, EP1116733, and DE10 2009 014877 (Clariant), EP1347736 (L'Oreal), or EP1496081 (Seppic). Examples include Aristoflex® AVC (ammonium acryloyldimethyl taurate / VP copolymer), Aristoflex® AVS (sodium acryloyldimethyl taurate / VP crosspolymer), Aristoflex® TAC (ammonium acryloyldimethyl taurate carboxyethyl acrylate crosspolymer), Hostacerin® AMP5 (ammonium polyacryloyldimethyl taurate), Aristoflex® HMB (ammonium acryloyldimethyl taurate / Beheneth-25 methacrylate crosspolymer), and Aristoflex® BLV (ammonium acryloyldimethyl taurate / Beheneth-25 methacrylate crosspolymer). Examples include taurate / Beheneth-25 methacrylate crosspolymer, Aristoflex® HMS (ammonium acryloyldimethyl taurate / Steareth-25 methacrylate crosspolymer), Aristoflex® SNC (ammonium acryloyldimethyl taurate / Steareth-8 methacrylate copolymer), Aristoflex® LNC (ammonium acryloyldimethyl taurate / Laureth-7 methacrylate copolymer), or Sepinov® EMT10 (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer), and Sepigel® 305.

[0162] In at least one embodiment, the thickening polymer is a copolymer of at least one first monomer type selected from acrylic acid and methacrylic acid, and at least one second monomer type selected from esters of acrylic acid and ethoxylated fatty alcohols; crosslinked polyacrylic acid; at least one first monomer type selected from acrylic acid and methacrylic acid, and C 10 ~C30 A crosslinked copolymer of at least one second monomer type selected from esters of acrylic acid with alcohol; a copolymer of at least one first monomer type selected from acrylic acid and methacrylic acid, and at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols; at least one first monomer type selected from acrylic acid and methacrylic acid, esters of itaconic acid and ethoxylated C 10 ~C 30 Copolymers of at least one second monomer type selected from alcohols, and a third monomer type selected from C1-C4 aminoalkyl acrylates; copolymers of two or more monomers selected from acrylic acid, methacrylic acid, acrylic esters, and methacrylic esters; copolymers of vinylpyrrolidone and ammonium acryloyldimethyltaurate; copolymers of ammonium acryloyldimethyltaurate and monomers selected from methacrylic acid esters and ethoxylated fatty alcohols; hydroxyethylcellulose; hydroxypropylcellulose; hydroxypropyl guar; glyceryl polyacrylate Selected from the group consisting of: phosphates; glyceryl polymethacrylates; copolymers of at least one C2-, C3-, or C4 alkylene and styrene; polyurethanes; hydroxypropyl starch phosphates; polyacrylamides; copolymers of maleic anhydride and methyl vinyl ether crosslinked with decadiene; carob seed flour; guar gum; xanthan gum; dehydroxanthan gum; carrageenan; karaya gum; hydrolyzed corn starch; copolymers of polyethylene oxide, fatty alcohols, and saturated methylenediphenyl diisocyanates (e.g., PEG-150 / stearyl alcohol / SMDI copolymer); and mixtures thereof.

[0163] In at least one embodiment, the pH value of the formulation is 2.0 to 12.0, preferably 3.0 to 9.0, and more preferably 4.5 to 7.5. By changing the pH value, formulations suitable for various applications can be utilized.

[0164] In at least one embodiment, the formulation includes an alkalizing agent or a pH adjuster. In at least one embodiment, ammonia or caustic soda is preferred, but water-soluble, physiologically acceptable salts of organic or inorganic bases may also be considered. Optionally, the pH adjuster is selected from ammonium bicarbonate, ammonia, monoethanolamine, and ammonium carbonate. In at least one embodiment, the alkalizing agent or pH adjuster is selected from the group consisting of 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydroxyl-methyl)-aminomethane, 2-amino-1-butanol, tris-(2-hydroxypropyl)-amine, 2,2-iminobisethanol, lysine, iminourea(guanidine carbonate), tetrahydro-1,4-oxazine, 2-amino-5-guanidine-valerian acid, 2-aminoethanesulfonic acid, diethanolamine, triethanolamine, N-methylethanolamine, isopropanolamine, diisopropanolamine, triisopropanolamine, glucamine, sodium hydroxide, potassium hydroxide, lithium hydroxide, magnesium oxide, and combinations thereof.

[0165] To achieve an acidic pH value, an acid may be included. In at least one embodiment, the formulation contains an acid selected from the group consisting of hydrochloric acid, phosphoric acid, acetic acid, formic acid, sulfuric acid, citric acid, and mixtures thereof. Citric acid is most preferred in that it has high consumer acceptance. In at least one embodiment, the acidic pH is adjusted with a buffer such as phosphate buffer, TRIS buffer, or citrate buffer. The buffer may be used alone or in combination with the acid.

[0166] The formulations of the present invention can be prepared by methods known in the art. For example, the formulations can be prepared by mixing the component materials, preferably at room temperature (20°C) and atmospheric pressure (10¹³ mbar). [Examples]

[0167] The following examples are intended to illustrate the present invention without limiting it.

[0168] [Table 1]

[0169] Preparation of ascorbic acid solution: Step 1. Weigh propylene glycol (PG) into a container and heat to 75-90°C. Step 2. Weigh the phospholipids and add them to the heated PG. Stir using an overhead stirrer at 75-90°C until a clear, homogeneous solution is achieved. Step 3. Weigh the PEG-40 monostearate and add it to the clear solution obtained in Step 2. Stir using an overhead stirrer at 75-90°C until a clear and homogeneous solution is obtained. Step 4. Weigh the hydroxyethyl urea and add it to the clear solution obtained in Step 3. Stir using an overhead stirrer at 75-90°C until a clear, homogeneous solution is obtained. Step 5. Weigh the ascorbic acid and add it to the clear solution obtained in Step 4. Stir using an overhead stirrer at 75-90°C until a clear, homogeneous solution is formed. Step 6. The temperature of the clear solution obtained in Step 5 is lowered to room temperature to obtain an ascorbic acid solution.

[0170] Preparation of aqueous ascorbic acid solution: Step 1. Weigh the ascorbic acid solution into a beaker and gently stir it at room temperature using an overhead stirrer. Step 2. Weigh the water and add it to the dropping funnel with the stopper closed. Add the water dropwise to the ascorbic acid solution from the dropping funnel, stirring gently with an overhead stirrer, and continue until a homogeneous mixture is obtained. Step 3. Store the ascorbic acid aqueous solution under standard storage conditions.

[0171] Measurement of ascorbic acid: 1% starch indicator solution: Mix 0.50g of soluble starch with a small amount of water to make a paste, and add it to 50ml of distilled water just before boiling while stirring. Stir for 1-5 minutes to make a uniform solution. After cooling, add 0.1-0.5 mg of potassium iodide.

[0172] Quantitative determination of ascorbic acid in the sample: Take 10 ml of standard ascorbic acid solution into an Erlenmeyer flask. Add 2-3 drops of starch indicator solution. Titrate with iodine solution and record the volume (V1). Next, collect 10 ml of ascorbic acid solution of unknown concentration. Add 2-3 drops of starch indicator solution. Titrate with iodine solution and record the volume (V2).

[0173] Calculation of ascorbic acid concentration in ascorbic acid sample (S2): S2 = V2 × S1 / V1 S1 is the concentration of the standard ascorbic acid solution (0.1% in this case). V1: Volume of iodine solution required to titrate 10 ml of standard ascorbic acid solution. V2: Volume of iodine solution required to titrate 10 ml of sample (ascorbic acid solution of unknown concentration)

[0174] [Table 2]

[0175] [Table 3]

[0176] Preparation of niacinamide solution: Step 1. Weigh propylene glycol (PG) into a container and heat to 75-90°C. Step 2. Weigh the phospholipids and add them to the heated PG. Stir using an overhead stirrer at 75-90°C until a clear, homogeneous solution is achieved. Step 3. Weigh the PEG-40 monostearate and add it to the clear solution obtained in Step 2. Stir using an overhead stirrer at 75-90°C until a clear and homogeneous solution is obtained. Step 4. Weigh the hydroxyethyl urea and add it to the clear solution obtained in Step 3. Stir using an overhead stirrer at 75-90°C until a clear and homogeneous solution is obtained. Step 5. Weigh the niacinamide and add it to the clear solution obtained in Step 4. Stir using an overhead stirrer at 75-90°C until a clear, homogeneous solution is formed. Step 6. Cooling: The temperature of the clear solution obtained in step 5 is lowered to 45°C to obtain the niacinamide solution.

[0177] Preparation of niacinamide aqueous solution: Step 1. Weigh the niacinamide solution into a beaker and gently stir it using an overhead stirrer at 45°C. Step 2. Weigh the water and set the temperature to 45°C. Add the water dropwise to the niacinamide solution and stir gently using an overhead stirrer until homogenized. Step 3. Store the niacinamide aqueous solution under standard storage conditions.

[0178] Measurement of niacinamide: The niacinamide content in the formulation is quantitatively analyzed using HPLC.

[0179] [Table 4]

[0180] In conclusion, the niacinamide composition of the present invention is stable.

[0181] HPLC method: 1. Equipment Method: Quantitative analysis by HPLC-DAD / UV Equipment: Agilent 1260 Infinity-II HPLC Column: Agilent Eclipse plus C-18, length 150 mm, inner diameter 4.6 mm × 3.5 μm (S / N USUXCO7215) Wavelength: 260±4nm Flow rate: 0.5 ml / min (gradient flow) Temperature: 40°C Injection volume: 5μl Analysis time: 18 minutes

[0182] Mobile phase: Eluent -1: 0.005 mol / l, tetrabutylammonium bisulfate:acetonitrile (95:5)%v / v Eluent-2: Acetonitrile (100%)

[0183] [Table 5]

[0184] 2. Procedure -Inject the diluted solution. - Inject the standard solution (100 ppm) twice. -Inject the diluted solution. -Inject the test solution. -Inject the diluted solution.

[0185] 3. Dilution solution: Acetonitrile:Water (70:30) v / v

[0186] 4. Standard solution Preparation of standard stock solution (1000 ppm): Weigh 25±10 mg of niacinamide into a 25 mL volumetric flask and add 20 mL of water. Dissolve by sonication and dilute with water to the mark. Preparation of standard solution (100 ppm): Dilute 1 mL of the stock solution with the diluent to a total of 10 mL.

[0187] 5. Test Solution Weigh 1000.0 ± 5.0 mg of the sample into a 100 mL volumetric flask. Next, add 50 mL of water to dissolve it, and then dilute with water to the mark. Further, pipette 1 mL of the solution and dilute it to 10 mL with the diluent.

[0188] 6. Evaluation Niacinamide content (%) = (Test area × Standard solution concentration) / (Standard solution area × Test solution concentration) × Purity of standard solution

[0189] Example 3 Use of aqueous niacinamide solution in facial serum chassis: Add the niacinamide composition from Example 2 to the facial serum chassis composition SC1 described below. The mixing ratio should be selected so that the final concentration of niacinamide in the facial serum chassis is 5%. Adjust the pH of all samples to 3. Store the samples at room temperature and 40°C.

[0190] [Table 6]

[0191] Measurement of niacinamide: The niacinamide content in the formulation is quantitatively analyzed using the HPLC method described in Example 2.

[0192] [Table 7]

[0193] The results show that the amount of niacinamide in the facial serum chassis containing the niacinamide composition according to the present invention is stable.

[0194] Example 4 Freezing test of niacinamide composition in Example 2 Mechanism: Niacinamide released from the sample diffuses through the dialysis membrane into the external compartment (buffer solution).

[0195] Procedure for determining the niacinamide release rate: - Tie one end of the dialysis tube with a thread. - Add 1 mL of the sample to the dialysis tube and tie the top with a thread. - Add 250 mL of pH 5.5 buffer solution to the beaker. - Place the dialysis tube containing the sample into a beaker. - Stir the buffer solution using a magnetic stirrer. - Take 1 mL aliquots (dialysis fluid) at different intervals. - The collected aliquots (dialysis fluid) are analyzed by HPLC as shown in Example 2 above.

[0196] Example 4a: Release test of a niacinamide composition with a niacinamide content of 10% The table below shows the percentage of niacinamide released at specific times, based on the initial amount of niacinamide (time point 0).

[0197] [Table 8]

[0198] The results show that the niacinamide composition of the present invention releases niacinamide more slowly than the comparative composition.

[0199] Example 4b: Release test of a niacinamide composition with a niacinamide content of 15% The table below shows the percentage of niacinamide released at specific times, based on the initial amount of niacinamide (time point 0).

[0200] [Table 9]

[0201] The results show that the niacinamide composition of the present invention releases niacinamide more slowly than the comparative composition.

[0202] Example 4c: Release test of a niacinamide composition with a niacinamide content of 15% The table below shows the percentage of niacinamide released at specific times, based on the initial amount of niacinamide (time point 0).

[0203] [Table 10]

[0204] The results show that the niacinamide composition of the present invention releases niacinamide more slowly than the comparative composition.

[0205] Example 5 Release test of facial serum chassis in Example 3 Mechanism and process for determining the niacinamide release rate: as described in Example 4. The table below shows the percentage of niacinamide released at specific times, based on the initial amount of niacinamide (time point 0).

[0206] [Table 11]

[0207] The results show that the facial serum chassis containing the niacinamide composition of the present invention releases niacinamide more slowly than the facial serum chassis of the comparative example.

[0208] Example 6 The vitamin compositions of Examples 1 and 2 can be incorporated into the serum chassis. Both of the vitamin compositions of Examples 1 and 2 can be mixed with the following serum chassis composition SC2. The mixing ratio can be selected so that the final concentration of niacinamide in the serum chassis is 5%. The pH of the resulting formulation can be adjusted to pH 3, pH 5, or pH 7.

[0209] [Table 12]

[0210] Example 7 The following aqueous niacinamide solutions (Examples 7-1 and 7-2) were prepared according to the method described in Example 2.

[0211] [Table 13]

[0212] The amount of niacinamide was measured as described in Example 2. [Table 14]

[0213] The result is that the niacinamide composition of the present invention is stable.

Claims

1. Vitamin composition containing the following ingredients: (a) Vitamins or their derivatives; (b) Lipid components; (c) Emulsifier (optional); (d) solvent; and (e) Optionally, urea or a derivative thereof.

2. The vitamin composition of claim 1, wherein the vitamin is selected from vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, and mixtures thereof, preferably, the vitamin is selected from vitamin B, vitamin C, and mixtures thereof.

3. The vitamin composition of claim 1 or 2, wherein the vitamin or its derivative is selected from ascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, tetrahexyldecyl ascorbate, ethylated ascorbic acid, 3-O-glycosyl-ascorbic acid, ascorbic acid 2-glucoside, and mixtures thereof.

4. The vitamin composition according to any one of claims 1 to 3, wherein the vitamin or its derivative is selected from niacin (nicotinic acid), niacinamide (nicotinamide), nicotinamide mononucleotide, nicotinamide riboside, dihydronicotinic acid riboside, 1-methylnicotinamide, inositol hexaniacinate, and mixtures thereof.

5. The vitamin composition according to any one of claims 1 to 4, wherein the lipid component is selected from lipids, phospholipids, and mixtures thereof, preferably the lipid component is selected from phospholipids.

6. The vitamin composition according to any one of claims 1 to 5, wherein the phospholipid is selected from phosphatidic acid, phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidylinositol phosphate, phosphatidylinositol bisphosphate, phosphatidylinositol trisphosphate, ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide phosphoryl lipid, and mixtures thereof, preferably the phospholipid is phosphatidylcholine.

7. The vitamin composition comprises (c) an emulsifier, wherein the emulsifier is preferably selected from aliphatic alcohols, fatty acids, glyceryl esters, sorbitan esters, sorbitol esters, polyglyceryl esters, sucrose esters, phosphates, aliphatic alcohol ethoxylates, fatty acid ethoxylates, lactylates, and mixtures thereof, more preferably the emulsifier is an aliphatic alcohol having 8 to 22 carbon atoms, a fatty acid having 8 to 22 carbon atoms, an ester of glycerol based on one or more C8 to C22 fatty acids, or an ester of sorbitan based on one or more C8 to C22 fatty acids. A vitamin composition according to any one of claims 1 to 6, selected from tel, sorbitol esters based on one or more C8-C22 fatty acids, polyglycerol esters based on one or more C8-C22 fatty acids, sucrose esters based on one or more C8-C22 fatty acids, phosphoric acid esters based on one or more C8-C22 aliphatic alcohols, phosphoric acid esters based on one or more ethoxylated C8-C22 aliphatic alcohols, C8-C22 aliphatic alcohol ethoxylates, C8-C22 fatty acid ethoxylates, lactic acid esters based on C8-C22 fatty acids, and mixtures thereof.

8. The solvent is selected from propylene glycol (1,2-propanediol), 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, dipropylene glycol, ethylene glycol, polyethylene glycol, sorbitol, glycerin, and mixtures thereof, the vitamin composition according to any one of claims 1 to 7.

9. The vitamin composition according to any one of claims 1 to 8, wherein (e) urea or a derivative thereof, wherein preferably the urea derivative is selected from 2-hydroxyethyl urea, 2-hydroxymethyl urea, bis(hydroxyethyl)urea, bis(hydroxymethyl)urea, N-(2-hydroxyethyl)ethylene urea, and mixtures thereof.

10. The vitamin composition according to any one of claims 1 to 9, further comprising (f) water.

11. The vitamin composition according to any one of claims 1 to 10, wherein the vitamin or its derivative is present in the vitamin composition in an amount of 1 to 40% by weight, preferably 5 to 30% by weight, more preferably 7 to 25% by weight, even more preferably 8 to 20% by weight, and particularly preferably 8 to 15% by weight, based on the total weight of the vitamin composition.

12. A method for producing any one of claims 1 to 11 of a vitamin composition, comprising the following steps: i) the step of preparing a mixture comprising a vitamin or its derivative, a lipid component, optionally an emulsifier, a solvent, and optionally urea or its derivative; and ii) Optionally, add water to the mixture obtained in step i).

13. Use of a mixture comprising lipid components, optionally an emulsifier, a solvent, optionally urea or its derivatives, and optionally water, for stabilizing vitamins or their derivatives, or for improving the bioavailability of vitamins or their derivatives.

14. Use of any vitamin composition according to claims 1 to 11 as an antioxidant, anti-aging agent, anti-wrinkle agent, skin whitening agent, skin brightening agent, depigmenting agent, anti-inflammatory agent, or anti-acne agent.

15. Use of any of the vitamin compositions of claims 1 to 11 for the purpose of strengthening the skin barrier, protecting the skin or hair from oxidative stress or damage (including UV-induced oxidative stress or damage), protecting the skin or hair from photoaging, protecting the skin from UV-induced immunosuppression, protecting the skin from UV-induced carcinogenesis, promoting keratinocyte differentiation, inducing collagen synthesis, or inhibiting melanin production.

16. Cosmetic formulations containing the following ingredients: (A) A vitamin composition according to any one of claims 1 to 11, wherein the vitamin composition is present in the cosmetic preparation in an amount such that the vitamin or its derivative is 1 to 30% by weight, preferably 5 to 25% by weight, more preferably 6 to 20% by weight, even more preferably 7 to 15% by weight, and particularly preferably 8 to 12% by weight, based on the total weight of the cosmetic preparation; and (B) One or more additional components.

Images