Cell culture systems with modified cellular microgravity and shear stress
The multi-axial rotating cell culture system addresses the challenge of simulating microgravity and fluid shear stress, offering a low-cost platform for studying cell behavior and processes, enhancing regulatory T-cell activation and nucleic acid delivery, and improving cell aggregation and transfection.
JP2026517707APending Publication Date: 2026-06-02RGT UNIV OF CALIFORNIA
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- RGT UNIV OF CALIFORNIA
- Filing Date
- 2024-04-25
- Publication Date
- 2026-06-02
Smart Images
Figure 2026517707000001_ABST
Abstract
A rotary cell culture system (RCCS) comprising at least one concentric ring mounted on a frame along its axis of rotation, and a DC motor coupled to at least one concentric ring via one or more gears and configured to rotate at least one concentric ring along its axis. The RCCS may further comprise at least two concentric rings, each of the at least two concentric rings mounted on an adjacent ring such that the axis of rotation of at least one concentric ring is perpendicular to the axis of rotation of any other concentric ring. The inner ring of the RCCS is configured to hold one or more sample holding members or structures, such as cell culture tubes or microwell plate structures.
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