Method for obtaining crystallized fetal bovine serum containing agmatine

The crystallization of fetal bovine serum using agmatine addresses storage and contamination issues, enhancing cell culture efficiency and reproducibility by allowing room temperature storage and maintaining formulation integrity.

JP2026520903APending Publication Date: 2026-06-25モエダノ ララ ラウル フランシスコ
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Patent Information

Application Number
JP2025570177
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-01
Filing Date
2024-04-08
Publication Date
2026-06-25

AI Technical Summary

Technical Problem

Current fetal bovine serum formulations require cold chain storage, leading to batch-to-batch variability, contamination risks, and high costs, limiting reproducibility and efficiency in cell culture applications.

Method used

A method for crystallizing fetal bovine serum using agmatine, which allows for storage at room temperature, reduces contamination, and maintains formulation integrity, enabling efficient dosage setting and distribution.

Benefits of technology

The crystallized fetal bovine serum maintains properties similar to liquid serum, enhances cell proliferation and protein expression, and reduces contamination risks, improving reproducibility and cost-effectiveness in cell culture.

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Abstract

The present invention relates to a method for obtaining crystallized fetal bovine serum by adding agmatine, which has the effect of increasing cell production and increasing protein expression per cell at a specific concentration. Furthermore, the method, with respect to a specific reconstitution form into a liquid, is shown for use without losing its original properties, allowing for storage without a cryogenic chain, reducing the risk of contamination, and enabling precise dosage.
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