Post-inflammatory hyperpigmentation treatment kit

Abstract

To provide a treatment device for treating post-inflammatory pigmentation occurring in association with mature scars accompanied by pigmentation formed on wounds, surgical wounds, insect bites, acne scars, etc., and scars and keloids with proliferation of collagen fibers (hereinafter referred to as scar keloids). [Solution] A treatment device for treating post-inflammatory pigmentation is made up of a stretch sheet 20 made of a multilayer polyolefin crystalline polymer resin, which is made of polyvinylidene chloride blended with an amorphous polymer of polyalkyl methacrylates, and a polyethylene resin / liquid paraffin ointment 21 made by mixing polyethylene with liquid paraffin containing hydroquinone-containing powder consisting of hydroquinone powder and ascorbic acid (vitamin C), and is attached to the epidermis 10 to protect the skin.

Description

[Technical field]

[0001] This invention relates to a therapeutic device for treating mature scars with pigmentation that form after trauma, surgical wounds, insect bites, acne scars, etc., and post-inflammatory pigmentation that occurs in association with scars and keloids caused by the proliferation of collagen fibers (hereinafter referred to as keloid scars). [Background technology]

[0002] Scars caused by trauma, surgery, insect bites, acne, etc. usually become white and soft "mature scars" over time, but if they are exposed to strong stimuli such as ultraviolet rays before the inflammation subsides, or in the case of keloid scars, where collagen fibers grow like a tumor, they may become pigmented and turn black or brown in color due to persistent inflammatory stimuli during the wound healing process. Scar pigmentation occurs when melanin pigment, secreted in large quantities by melanocytes, cells on the surface of the skin (epidermal layer), is deposited in the epidermis and dermis. Melanocytes, also known as "pigment cells," become activated when they receive strong stimuli and produce large amounts of "melanin pigment" to protect the skin. If there is an appropriate amount of melanin, it will be discharged from the skin within a certain period of time through metabolism (turnover), but if there is too much, the turnover cannot keep up, and the melanin that cannot be discharged accumulates in the scar, causing pigmentation. The main causes of pigmentation are physical stimuli, contact with air, and stimuli from ultraviolet rays. Scars on the face, arms, legs, and other parts that are not protected by clothing are easily exposed to ultraviolet rays and are therefore prone to pigmentation.Although this does not affect the function of the body, as these parts are easily visible to others, depending on the size and condition of the scar, it can cause complexes and lead to a decrease in the patient's quality of life (QOL).

[0003] To solve these problems, hydrocolloid-containing sheets are known as treatment tools that can be applied to wounds on the skin to prevent irritation to the wound and promote wound healing. Hydrocolloids used in moist wound healing turn into a gel when they come into contact with exudate, becoming white and swollen. The gel pads, which are fully saturated with exudate, protect the wound, and therefore speed up the recovery from the wound.

[0004] Hydrocolloid-containing sheets are generally made from an elastomer material containing a water-absorbent hydrocolloid (Patent Documents 1 to 3). When the hydrocolloid-containing sheet is applied to a wound, the hydrocolloid absorbs and retains the body fluids that seep out from the wound. Body fluids inherently contain components that promote wound repair, and the retention of body fluids in the hydrocolloid promotes wound healing. Therefore, unlike general bandages, hydrocolloid-containing sheets do not contain chemicals such as disinfectants, and it is considered that the combined use of hydrocolloid-containing sheets with topical agents should not be carried out as it may worsen skin diseases. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 6-9373 [Patent Document 2] Special Publication No. 2002-512295 [Patent Document 3] JP 2011-45494 A

[0006] The hydrocolloid-containing sheets used in these prior art technologies are made of expensive materials, which impose a large financial burden on patients. In addition, with continued use, the sheets may soften and stick to clothing covering the affected area, or may cause bacterial infections in closed spaces. Furthermore, use in combination with topical agents is considered to be risky as it may worsen skin diseases, and therefore the effectiveness of the sheets is limited. Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention has been made in consideration of the above circumstances, and aims to provide a device for treating post-inflammatory hyperpigmentation that can also inhibit the production of melanin pigment in the treatment of post-inflammatory hyperpigmentation, is made of inexpensive materials, and places a small burden on the patient. [Means for solving the problem]

[0008] In order to meet such a purpose, the post-inflammatory hyperpigmentation treatment device according to the present invention comprises a stretch sheet made of a multi-layer polyolefin crystalline polymer resin, which is made of polyvinylidene chloride blended with an amorphous polymer of polyalkyl methacrylates having airtightness, flexibility, and stretchability; A polyethylene resin liquid paraffin ointment containing hydroquinone-containing powder consisting of hydroquinone powder and ascorbic acid (vitamin C) mixed with liquid paraffin and polyethylene; The present invention is characterized in that it is composed of:

[0009] According to this configuration, the airtight and UV-blocking stretch sheet prevents physical irritation, contact with air, and irritation from UV rays, thereby preventing the progression of post-inflammatory pigmentation, while the hydroquinone and ascorbic acid suppress the production of melanin pigment, and the ascorbic acid prevents the oxidation of hydroquinone, thereby sustaining the effect, thereby preventing post-inflammatory pigmentation.

[0010] Furthermore, in order to meet such a purpose, the thickness of the resin stretch sheet of the post-inflammatory hyperpigmentation treatment device according to the present invention is characterized to be 0.008 mm to 0.011 mm.

[0011] With this configuration, it is possible to maintain flexibility and stretchability while providing sufficient airtightness.

[0012] Furthermore, in order to meet such objectives, the hydroquinone content of the hydroquinone-containing powder used in the post-inflammatory pigmentation treatment device of the present invention is characterized in that the liquid paraffin contained in the polyethylene resin-liquid paraffin ointment is 70% to 90%, and the hydroquinone content in the polyethylene resin-liquid paraffin ointment is 2% to 4%.

[0013] According to this configuration, it is possible to reduce melanocytes, which are a component that reduces the cells themselves that produce the melanin pigment that causes blemishes in cells. Effect of the Invention

[0014] As described above, the post-inflammatory hyperpigmentation treatment device of the present invention has the excellent effect of preventing the progression of post-inflammatory hyperpigmentation by preventing physical stimuli, contact with air, and stimuli caused by ultraviolet rays in the treatment of post-inflammatory hyperpigmentation, inhibiting the production of melanin pigment by hydroquinone, preventing the oxidation of hydroquinone by ascorbic acid to maintain the effect, and being made of inexpensive materials, thereby reducing the economic burden on the patient. In addition, the device does not soften with continued use and stick to clothing covering the affected area, does not cause bacterial infection in closed spaces, and can be used in combination with topical agents, thereby providing the effects of the topical agents. [Brief description of the drawings]

[0015] [Figure 1] FIG. 1 shows the state of post-inflammatory hyperpigmentation in a scar. [Diagram 2] FIG. 2 is a cross-sectional view of the post-inflammatory hyperpigmentation treatment device of the present invention applied to the epidermis. [Diagram 3] FIG. 3 is a diagram showing the post-inflammatory hyperpigmentation treatment device of the present invention being used on the post-inflammatory hyperpigmentation of FIG. 1. [Figure 4] FIG. 4 is a diagram showing the state after the post-inflammatory hyperpigmentation treatment device according to the present invention has been used on the post-inflammatory hyperpigmentation of FIG. [Diagram 5] FIG. 5 is a photograph of Treatment Example 1 at the start of treatment. [Figure 6] Figure 6 is a photograph of Treatment Example 2 at the start of treatment. [Figure 7] FIG. 7 shows photographs of the first intermediate stage of Treatment Example 1. [Figure 8] FIG. 8 shows photographs of the first intermediate stage of treatment example 2. [Figure 9] Figure 9 shows photographs of the second intermediate stage of treatment example 1 and treatment example 2. [Figure 10] Figure 10 shows photographs of the treatment results for Treatment Examples 1 and 2. [Figure 11] FIG. 11 is a photograph of Treatment Example 3 at the start of treatment. [Figure 12] FIG. 12 shows photographs of the first intermediate stage of treatment example 3. [Figure 13] FIG. 13 shows photographs of the second intermediate stage of treatment example 3. [Figure 14] FIG. 14 is a photograph of the treatment result of treatment example 3. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] The present invention has the above-mentioned configuration, and the embodiment of the present invention will be described with reference to the drawings.

[0017] 1 to 4 are diagrams illustrating the process of using the post-inflammatory hyperpigmentation treatment device according to the present invention. FIG. 1 shows the state at the start of treatment, with a lesion 11 appearing on the epidermis 10.

[0018] FIG. 2 is a cross-sectional view of the post-inflammatory pigmentation treatment device of the present invention being used on the epidermis, in which polyethylene resin / liquid paraffin ointment 21 is applied to the epidermis 10, and a stretch sheet 20 is attached on top of it to protect the skin.

[0019] FIG. 3 shows the post-inflammatory hyperpigmentation treatment device of the present invention being used on the post-inflammatory hyperpigmentation of FIG. 1 as shown in FIG. 2, with a stretch sheet 20 affixed to the affected area 11 of the epidermis 10 to protect the skin.

[0020] FIG. 4 is a diagram showing the state after the post-inflammatory hyperpigmentation treatment device according to the present invention has been used on the post-inflammatory hyperpigmentation of FIG. 1, showing that the post-inflammatory hyperpigmentation of the affected area 11 has been alleviated. The following is an actual treatment example. The thickness of the stretch sheet made of multi-layer polyolefin crystalline polymer resin, which is made of polyvinylidene chloride blended with amorphous polymer of polyalkyl methacrylates having airtightness, flexibility and stretchability, is preferably 0.008mm to 0.011mm. In the following treatment example, a stretch sheet of 0.010mm was used. A polyethylene mixed with polyethylene and liquid paraffin containing hydroquinone-containing powder consisting of hydroquinone powder and ascorbic acid (vitamin C) was used. It is desirable that the hydroquinone content of the hydroquinone-containing powder in the polyethylene resin / liquid paraffin ointment be 70% to 90%, the liquid paraffin contained in the polyethylene resin / liquid paraffin ointment be 70% to 90%, and the hydroquinone content in the polyethylene resin / liquid paraffin ointment be 2% to 4%; in the treatment example below, a hydroquinone-containing powder with a hydroquinone content of 80% and a polyethylene resin / liquid paraffin ointment with a hydroquinone content of 3.9-4.0% are used.

[0021] Figure 5 is a photograph at the start of treatment in Treatment Example 1. Intense darkening can be seen in the affected area A34 of Patient A, circled in a line. Treatment in Treatment Example 1 began immediately after re-epithelialization after injury.

[0022] Figure 6 is a photograph at the start of treatment in Treatment Example 2. Intense darkening can be seen in the affected area B35 of Patient A, circled in a line. Treatment in Treatment Example 2 began immediately after re-epithelialization after injury.

[0023] Figure 7 is a photograph of the first intermediate progress of Treatment Example 1 of Figure 5. At the intermediate progress 25 days after the start of treatment, the severe darkening on the affected area A34 of Patient A, circled in a line, has been significantly alleviated.

[0024] Figure 8 is a photograph of the first intermediate progress of Treatment Example 2 of Figure 6. At the intermediate progress 25 days after the start of treatment, the severe darkening on the affected area B35 of Patient A, circled in a line, has been significantly alleviated.

[0025] Figure 9 is a photograph of the second intermediate progress of Treatment Example 1 and Treatment Example 2. At the intermediate progress 50 days after the start of treatment, the severe darkening in affected area A34 of Patient A and affected area B35 of Patient A, which are circled in a line, has been further alleviated.

[0026] Figure 10 is a photograph of the treatment results of Treatment Examples 1 and 2. In the treatment results 85 days after the start of treatment, the intense darkening in affected areas A34 and B35 of Patient A, circled in lines, has almost completely disappeared.

[0027] Figure 11 is a photograph at the start of treatment in Treatment Example 3. Intense darkening can be seen in the affected area 36 of Patient B, which is circled in a line. Treatment in Treatment Example 3 began 10 years after the injury.

[0028] Fig. 12 is a photograph showing the first intermediate progress of Treatment Example 3 of Fig. 11. At the intermediate progress 35 days after the start of treatment, the intense darkening in the affected area 36 of Patient B, circled in a line, has not changed much.

[0029] Figure 13 is a photograph showing the second intermediate progress of Treatment Example 3 of Figure 11. At the intermediate progress 63 days after the start of treatment, the severe darkening in the affected area 36 of Patient B, circled in a line, has been slightly alleviated.

[0030] 14 is a photograph showing the treatment result of Treatment Example 3. At the midpoint of 112 days after the start of treatment, the severe darkening in the affected area 36 of Patient B, circled in a line, has been significantly alleviated.

[0031] As described above, the post-inflammatory hyperpigmentation treatment device of the present invention has the following excellent effects: in the treatment of post-inflammatory hyperpigmentation, by using a stretch sheet of an appropriate thickness, physical irritation, contact with air, and irritation from ultraviolet rays are prevented, thereby preventing the progression of post-inflammatory hyperpigmentation; and by suppressing the production of melanin pigment with a polyethylene resin-liquid paraffin ointment made of a mixture of liquid paraffin and polyethylene, which contains hydroquinone-containing powder consisting of an appropriate concentration of hydroquinone powder and ascorbic acid (vitamin C), post-inflammatory hyperpigmentation can be prevented; the device is made of inexpensive materials, which reduces the economic burden on the patient; it does not soften with continued use and stick to the clothing covering the affected area; it can be used in combination with topical agents, and it has the excellent effects of providing a post-inflammatory hyperpigmentation treatment device that also provides the effects of the topical agents. [Explanation of symbols]

[0032] 10 Epidermis 11 Affected area 20 Stretch Sheet 21 Polyethylene resin / liquid paraffin ointment 34 Patient A Affected area A 35 Patient A Affected area B 36 Patient C affected area

Claims

1. A stretch sheet made of a multi-layer polyolefin crystalline polymer resin, which is made of polyvinylidene chloride blended with an amorphous polymer of polyalkyl methacrylates; A polyethylene resin / liquid paraffin ointment made by mixing liquid paraffin and polyethylene, which contains hydroquinone-containing powder consisting of hydroquinone powder and ascorbic acid (vitamin C); A post-inflammatory hyperpigmentation treatment device comprising:

2. 2. The post-inflammatory hyperpigmentation treatment device according to claim 1, wherein the thickness of the stretch sheet is 0.008 mm to 0.01 mm.

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