Biological sample honeycomb-type storage tank

Abstract

Disclosed is a biological sample honeycomb type storage tank including a storage tank body (1) composed of a storage tank body (11) and a storage tank lid (12). Inside the storage tank body, a fixing operation mechanism (2), a rotary storage mechanism (3), and a liquid nitrogen cold insulation mechanism (4) are provided in order from top to bottom. The fixing operation mechanism is provided below an operation window (121) opened in the storage tank lid, and performs the operation of taking out and / or picking up a cryogenic storage tube inside the storage tank body. The rotary storage mechanism arranges an aluminum tube in which the cryogenic storage tube is accommodated, and moves the aluminum tube to be the target of the taking out and / or picking up operation below the fixing operation mechanism. The liquid nitrogen cold insulation mechanism stores liquid nitrogen and continuously cools the fixing operation mechanism and the rotary storage mechanism from the bottom of the storage tank body. The storage tank can directly perform operations such as taking out and picking up a cryogenic storage tube in a frozen environment area, avoiding the risk of damage due to the exposure of the cryogenic storage tube to room temperature, and realizing the function of continuously providing cold insulation to the storage tank.

Description

Technical Field

[0001] The present invention relates to a honeycomb-type storage tank for biological samples and belongs to the technical field of biological sample storage.

Background Art

[0002] Cryogenic biological sample banks are important basic equipment for current research in the pharmaceutical and biological fields, and can maintain biological tissues such as blood, stem cells, and immune cells in an active state over a long period of time by cryopreservation in liquid nitrogen.

[0003] In the prior art, in each case, the taken-out biological sample is first accommodated in a cryogenic storage tube, then the cryogenic storage tube is accommodated in an aluminum tube, and then the aluminum tube is placed and stored in a liquid nitrogen sample storage tank.

[0004] Currently, in a normal sample storage tank, when taking out a cryogenic storage tube in cryogenic storage, first, the cryogenic storage tube is taken out of the body and a pickup and transfer operation is performed. However, if this is done, the cryogenic storage tube will reach room temperature or its temperature will recover, both of which will incur the risk of sample damage. For example, as an existing transfer and storage mechanism for biological samples, its application number is CN201821964119.0. In this solution, the taken-out plate rack or cryogenic storage tube must be transferred to the operation room, so there is a risk of being exposed to room temperature and affecting the survival of biological samples.

Summary of the Invention

Problems to be Solved by the Invention

[0005] An object of the present invention is to provide a honeycomb-type storage tank for biological samples, which can solve the problem of a complete cold chain during the process of taking out the cryogenic storage tube, and can also solve the problem of strengthening the continuous heat preservation function of liquid nitrogen inside the body.

Means for Solving the Problems

[0006] To solve the technical problems, the present invention adopts the following technical solutions. A biological sample honeycomb-type storage tank including a storage tank body composed of a storage tank body and a storage tank lid, wherein a fixing operation mechanism, a rotary storage mechanism, and a liquid nitrogen cooling mechanism are sequentially provided from top to bottom inside the storage tank body. The fixing operation mechanism is provided below an operation window opened in the storage tank lid, and the freezing storage tube is taken out and / or picked up inside the storage tank body. The rotary storage mechanism arranges an aluminum tube containing a freezing storage tube, and moves the aluminum tube to be the object of the taking-out and / or picking-up operation below the fixing operation mechanism. The liquid nitrogen cooling mechanism stores liquid nitrogen and continuously cools the fixing operation mechanism and the rotary storage mechanism from the bottom of the storage tank body.

[0007] Preferably, vacuum cavities are provided on both the side wall and the bottom wall of the storage tank body, and a housing of a vacuum intermediate layer is further provided outside the storage tank body.

[0008] Preferably, a removable blocking cover is provided on the operation window.

[0009] Preferably, both the operation window and the blocking cover are elongated and overlap with the rotating unit of the rotary storage mechanism.

[0010] Preferably, a take-out portion is provided on the upper part of the blocking cover, and the blocking cover is opened and closed by being connected to cooperate with a robot arm outside the storage tank body.

[0011] Preferably, a heat insulation structure is further filled in the region between the storage tank lid and the rotary storage mechanism, avoiding the fixing operation mechanism.

[0012] Preferably, the rotary storage mechanism includes an upper honeycomb storage plate, a lower honeycomb storage plate, and a central rotating shaft. The upper honeycomb storage plate and the lower honeycomb storage plate are arranged on the central rotating shaft with a gap therebetween in the up-and-down direction to form a honeycomb structure for storing aluminum tubes, and intermediate positions of both are rotatably connected to the central rotating shaft.

[0013] Preferably, circumferential edges of the upper honeycomb storage plate and the lower honeycomb storage plate are fixed and connected by a plurality of support members uniformly distributed. A rotating ring gear is provided on an upper peripheral portion of the upper honeycomb storage plate, and is meshed and connected to a rotating drive member outside the storage tank body by a gear.

[0014] Preferably, the support member is a support rod with a hollow structure, and cold conduction air inlets and cold conduction air outlets are respectively opened at both ends thereof.

[0015] Preferably, an outer periphery of the upper honeycomb storage plate is slidably connected to the storage tank body by a guide structure.

[0016] Preferably, the guide structure includes an annular guide rail fixedly connected to an outer periphery of the upper honeycomb storage plate, and several guide movable blocks fixedly connected to four circumferential sides of an inner wall of the storage tank body. The guide movable blocks are slidably attached to the annular guide rail.

[0017] Preferably, the fixing operation mechanism includes a guide plate and a plate track arranged in parallel in the rotation direction of the rotary storage mechanism. A pickup hole for taking out a frozen storage tube is provided on the guide plate, and the plate track picks up the frozen storage tube.

[0018] Preferably, a temperature sensor is further provided on the plate track to detect the temperature of the plate track accommodated in the guide plate.

[0019] Preferably, the fixing operation mechanism is connected to the radial position of the cross-section of the storage tank body by a fixing plate, arranged close to the top part of the rotary storage mechanism, and a through-type nitrogen discharge port is opened in the fixing plate.

[0020] Preferably, the liquid nitrogen cold insulation mechanism includes a central inner cylinder, the central rotating shaft is rotatably provided at the upper part of the central inner cylinder, and a nitrogen ejection port and a liquid supply tube are respectively provided at the upper end and the lower end of the central inner cylinder.

Advantages of the Invention

[0021] The above technical solution of the present invention has the following beneficial effects. Inside the storage tank body, a fixing operation mechanism, a rotary storage mechanism, and a liquid nitrogen cold insulation mechanism are provided in sequence from top to bottom. Thus, 1) The fixing operation mechanism directly performs operations such as taking out and picking up the frozen storage tube inside the storage tank body in the freezing environment area, avoiding the risk of damage caused by the exposure of the frozen storage tube to normal temperature. 2) The liquid nitrogen cold insulation mechanism at the bottom stores a predetermined amount of liquid nitrogen, realizes the purpose of continuously providing a cold insulation effect to the storage tank body, and ensures that the storage area and the operation area where the fixing operation mechanism and the rotary storage mechanism are located are always in a freezing environment.

Brief Description of the Drawings

[0022]

Figure 1

Figure 2

Figure 3

Figure 4

Embodiment for Carrying out the Invention

[0023] Hereinafter, the technical solution of the present invention will be further described in combination with embodiments and drawings.

[0024] This embodiment provides a biological sample honeycomb type storage tank including a storage tank body 1 composed of a storage tank body 11 and a storage tank lid 12. Inside the storage tank body 11, a fixing operation mechanism 2, a rotary storage mechanism 3, and a liquid nitrogen cold insulation mechanism 4 are provided in order from top to bottom. The fixing operation mechanism 2 is provided below an operation window 121 opened in the storage tank lid 12, and performs the operation of taking out and / or picking up a frozen storage tube inside the storage tank body 11. The rotary storage mechanism 3 arranges an aluminum tube containing a frozen storage tube, and moves the aluminum tube to be the target of the take-out and / or pick-up operation below the fixing operation mechanism 2. The liquid nitrogen cold insulation mechanism 4 stores liquid nitrogen and continuously cools the fixing operation mechanism 2 and the rotary storage mechanism 3 from the bottom of the storage tank body 11.

[0025] The fixing operation mechanism 2 provided below the operation window 121 opened in the storage tank lid 12 and located above the rotary storage mechanism 3 can directly perform operations such as taking out and picking up a frozen storage tube inside the storage tank body 11 in the frozen environment area, avoiding the risk of damage due to the frozen storage tube being exposed to room temperature. The liquid nitrogen cold insulation mechanism 4 provided below the fixing operation mechanism 2 and the rotary storage mechanism 3 stores a predetermined amount of liquid nitrogen and can continuously provide a complete cold chain environment for the storage and operation of the frozen storage tube from the bottom of the storage tank body 11.

[0026] As a further embodiment of the present invention, vacuum cavities 111 are provided on both the side wall and the bottom wall of the storage tank body 11, and a housing 13 of the vacuum space layer 131 is further provided outside the storage tank body 11.

[0027] The housing 13 further protects and mounts the storage tank body 11, and its vacuum space layer 131 further keeps the temperature of the storage tank body 11 cold. The side wall and the bottom wall of the storage tank body 11 of the vacuum cavity 111 maintain internal freezing.

[0028] As a further embodiment of the present invention, a removable shielding cover 122 is provided on the operation window 121. The shielding cover 122 is opened when it is necessary to operate the cryogenic storage tube by the fixed operation mechanism 2, and is immediately closed after use, thereby reducing the amount of liquid nitrogen used.

[0029] As a further embodiment of the present invention, both the operation window 121 and the shielding cover 122 are elongated and overlap with the rotating unit of the rotating storage mechanism 3.

[0030] Regarding the elongated design that overlaps with the rotating unit of the rotating storage mechanism 3, all the aluminum tubes on the rotating storage mechanism 3 appear in the form of the rotating unit in sequence at the operation window 121. On the premise that there is no leakage, an excellent effect of making the window size as small as possible is achieved.

[0031] As a further embodiment of the present invention, a take-out portion 1221 is provided on the upper part of the shielding cover 122 and is connected to cooperate with a robot arm outside the storage tank body 1 to open and close the shielding cover 122.

[0032] In order to make the operation easier, a take-out portion 1221 is provided. The specific structure of the take-out portion 1221 is a hook portion or a magnetic attraction portion, which is connected to the robot arm so as to be suspended or adsorbed, and is further taken out or returned.

[0033] As a further embodiment of the present invention, a heat preservation structure 5 is further filled in the area between the storage tank lid 12 and the rotary storage mechanism 3, avoiding the fixing operation mechanism 2.

[0034] The heat preservation structure 5 mainly cools from the storage tank lid 12 above, and together with the vacuum cavities 111 at the bottom and side parts and the housing 13 of the vacuum intermediate layer 131, constructs an overall heat preservation system for the storage tank. In addition, the heat preservation structure 5 particularly guarantees the continuous low temperature of the fixing operation mechanism 2 and the rotary storage mechanism 3, and saves the nitrogen usage amount.

[0035] As a further embodiment of the present invention, the rotary storage mechanism 3 includes an upper honeycomb storage plate 31, a lower honeycomb storage plate 32 and a central rotating shaft 33. The upper honeycomb storage plate 31 and the lower honeycomb storage plate 32 are arranged on the central rotating shaft 33 with a gap therebetween up and down, forming a honeycomb-type structure for storing aluminum tubes, and intermediate positions of both are rotatably connected to the central rotating shaft 33.

[0036] Regarding the structures of the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32, as their names imply, many hole positions penetrating up and down for arranging aluminum tubes are provided. After having a gap, both present an overall honeycomb-type structure with the central rotating shaft 33, and the whole honeycomb-type structure rotates along with the central rotating shaft 33 and appears in turn at the position of the operation window 121 to meet the operation needs.

[0037] As a further embodiment of the present invention, circumferential edges of the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32 are fixed and connected by a plurality of support members 34 uniformly distributed. A rotating ring gear 351 is provided at the upper peripheral part of the upper honeycomb storage plate 31 and meshed and connected to a rotary driving member 36 outside the storage tank body 11 by a gear 352.

[0038] The support member 34 strengthens the firmness of the entire honeycomb structure. The rotation drive member 36 may be a drive motor, and is engaged and connected to the rotation ring gear 351 of the upper honeycomb storage plate 31 by a gear 352 coaxially connected to the drive motor, so as to realize the purpose of driving the drive motor to directly rotate the honeycomb structure, and such a transmission form improves the rotation accuracy and realizes a more accurate rotation to select the required cryogenic storage tube.

[0039] As a further embodiment of the present invention, the support member 34 is a support rod with a hollow structure, and a cold conduction air inlet and a cold conduction air outlet are respectively opened at both ends thereof.

[0040] While connecting the upper honeycomb storage plate 31 and the lower honeycomb storage plate 32, the support rod with a hollow structure further conducts liquid nitrogen through its cold conduction air inlet and cold conduction air outlet to strengthen the continuous cold preservation function inside the rotary storage mechanism 3, and also contributes to the upward transmission of liquid nitrogen.

[0041] As a further embodiment of the present invention, the outer periphery of the upper honeycomb storage plate 31 is slidably connected to the storage tank body 11 by a guide structure 37.

[0042] By arranging the guide structure 37, the stability and certainty of the transmission process for realizing the rotation of the rotary storage mechanism 3 are further improved.

[0043] As a further embodiment of the present invention, the guide structure 37 includes an annular guide rail 371 fixedly connected to the outer periphery of the upper honeycomb storage plate 31, and several guide movable blocks 372 fixedly connected to the four circumferential sides of the inner wall of the storage tank body 11, and the guide movable blocks 372 are slidably attached to the annular guide rail 371.

[0044] Specifically, the storage tank body 11 and the rotary storage mechanism 3 realize relative sliding in the circumferential direction through a sliding structure composed of a guide movable block 372 and an annular guide rail 371.

[0045] As a further embodiment of the present invention, the fixed operation mechanism 2 includes a guide plate 21 and a plate track 22 arranged in parallel in the rotation direction of the rotary storage mechanism 3. The guide plate 21 is provided with a pickup hole 211 for taking out the frozen storage tube, and the plate track 22 picks up the frozen storage tube.

[0046] The guide plate 21 and the plate track 22 are jointly located at the position of the operation window 121. In order to achieve complete coverage, the guide plate 21 is further superimposed on the rotating unit of the rotary storage mechanism 3, mainly picking up the frozen storage tube in the aluminum tube and putting it into the plate track 22, and then adjusting it to the required frozen storage tube in the plate track 22.

[0047] As a further embodiment of the present invention, the plate track 22 is further provided with a temperature sensor 221 to detect the temperature of the plate track 22 accommodated in the guide plate 21. It is used for being associated with intelligent adjustment and control.

[0048] As a further embodiment of the present invention, the fixed operation mechanism 2 is connected to the radial position of the cross-sectional diameter of the storage tank body 11 by a fixed plate 23 and is arranged close to the top of the rotary storage mechanism 3. The fixed plate 23 is provided with a through-type nitrogen discharge port 231.

[0049] The fixed plate 23 realizes the mounting needs of the fixed operation mechanism 2 and ensures the effective flow of liquid nitrogen through the through-type nitrogen discharge port 231. Here, the through-type nitrogen discharge port 231 may be a fan-shaped notch provided between the mounting parts, or a strip-shaped through-hole provided in the mounting parts, or both of them may be adopted simultaneously.

[0050] As a further embodiment of the present invention, the liquid nitrogen cold storage mechanism 4 includes a central inner cylinder 41, the central rotating shaft 33 is rotatably provided on the upper part of the central inner cylinder 41, and a nitrogen ejection port 411 and a liquid supply tube are respectively provided at the upper end and the lower end of the central inner cylinder 41.

[0051] First, liquid nitrogen enters the central inner cylinder 41 from the outside through the liquid supply tube 412, stores a predetermined amount of liquid nitrogen in the central inner cylinder 41, and at the same time, continuously discharges nitrogen from the nitrogen ejection port 411 into the storage tank body 11 to achieve the purpose of continuous cold storage.

[0052] Finally, the above embodiments do not limit the technical solution of the present invention and are only for illustration. Although the present invention has been described in detail with reference to the above embodiments, as can be understood by those skilled in the art, still, the technical solutions described in the above embodiments can be corrected, or equivalent replacements can be made for some of their technical features, and the essence of the corresponding technical solutions does not deviate from the spirit and scope of the technical solutions of the embodiments of the present invention due to these corrections or replacements.

Explanation of Reference Numerals

[0053] 1 Storage tank body 11 Storage tank body 111 Vacuum cavity 12 Storage tank lid 121 Operation window 122 Shut-off cover 1221 Take-out part 13 Housing 131 Vacuum intermediate layer 2 Fixed operation mechanism 21 Guide plate 211 Pick-up hole 22 Plate track 221 Temperature sensor 23 Fixed plate 231 Through-type nitrogen discharge port 3 Rotating storage mechanism 31 Upper honeycomb storage plate 32 Lower honeycomb storage plate 33 Central rotating shaft 34 Support member 351 Rotating ring gear 352 Gear 36 Rotation drive member 37 Guide structure 371 Annular guide rail 372 Guide movable block 4 Liquid nitrogen cold insulation mechanism 41 Central inner cylinder 411 Nitrogen jet outlet 412 Liquid supply tube 5 Heat insulation structure

Claims

1. A biological sample honeycomb type storage tank including a storage tank body composed of a storage tank body and a storage tank lid, wherein a fixing operation mechanism, a rotary storage mechanism, and a liquid nitrogen cold insulation mechanism are provided in the storage tank body in order from top to bottom, The fixing operation mechanism is provided below an operation window opened in the storage tank lid, and performs an operation of taking out and / or picking up a cryogenic storage tube inside the storage tank body, The rotary storage mechanism arranges an aluminum tube in which a cryogenic storage tube is accommodated, and moves the aluminum tube to be the target of the taking out and / or picking up operation below the fixing operation mechanism, The liquid nitrogen cold insulation mechanism stores liquid nitrogen and continuously cools the fixing operation mechanism and the rotary storage mechanism from the bottom of the storage tank body, and is characterized in that it is a biological sample honeycomb type storage tank.

2. The biological sample honeycomb type storage tank according to claim 1, wherein vacuum cavities are provided on both the side wall and the bottom wall of the storage tank body, and a housing of a vacuum intermediate layer is further provided outside the storage tank body.

3. The biological sample honeycomb type storage tank according to claim 2, wherein a removable blocking cover is provided on the operation window.

4. The biological sample honeycomb type storage tank according to claim 3, wherein both the operation window and the blocking cover are elongated and are superimposed on a rotating unit of the rotary storage mechanism.

5. The biological sample honeycomb type storage tank according to claim 4, wherein a take-out part is provided on the upper part of the blocking cover, and the blocking cover is opened and closed by being connected so as to cooperate with a robot arm outside the storage tank body.

6. The biological sample honeycomb type storage tank according to claim 1, 2, 3, 4, or 5, characterized in that a heat preservation structure is further filled in a region avoiding the fixed operation mechanism between the storage tank lid and the rotary storage mechanism.

7. The rotary storage mechanism includes an upper honeycomb storage plate, a lower honeycomb storage plate, and a central rotation shaft. The upper honeycomb storage plate and the lower honeycomb storage plate are arranged on the central rotation shaft so as to be spaced apart from each other up and down, forming a honeycomb type structure for storing aluminum tubes, and intermediate positions of both are rotatably connected to the central rotation shaft. The biological sample honeycomb type storage tank according to claim 1.

8. The circumferential edges of the upper honeycomb storage plate and the lower honeycomb storage plate are fixed and connected by a plurality of support members uniformly distributed. A rotation ring gear is provided on the upper peripheral portion of the upper honeycomb storage plate, and is meshed and connected to a rotation drive member outside the storage tank body by a gear. The biological sample honeycomb type storage tank according to claim 7.

9. The support member is a support rod with a hollow structure, and cold conduction air inlets and cold conduction air outlets are respectively opened at both ends thereof. The biological sample honeycomb type storage tank according to claim 8.

10. The outer periphery of the upper honeycomb storage plate is slidably connected to the storage tank body by a guide structure. The biological sample honeycomb type storage tank according to claim 7.

11. The guide structure includes an annular guide rail fixed and connected to the outer periphery of the upper honeycomb storage plate, and several guide movable blocks fixed and connected to the four circumferential sides of the inner wall of the storage tank body. The guide movable blocks are slidably attached to the annular guide rail. The biological sample honeycomb type storage tank according to claim 10.

12. The fixed operation mechanism includes a guide plate and a plate track that are arranged in parallel in the rotation direction of the rotary storage mechanism. The guide plate is provided with a pickup hole for taking out the frozen storage tube. The plate track picks up the frozen storage tube. The biological sample honeycomb type storage tank according to claim 1, 2, 3, 4, 5, 7, 8, 9, 10, or 11, characterized in that.

13. The plate track is further provided with a temperature sensor, and the biological sample honeycomb type storage tank according to claim 12, characterized in that the temperature of the plate track accommodated in the guide plate is detected.

14. The fixed operation mechanism is connected to the radial position of the cross section of the storage tank body by a fixed plate, is arranged close to the top of the rotary storage mechanism, and the fixed plate is provided with a through nitrogen discharge port. The biological sample honeycomb type storage tank according to claim 12, characterized in that.

15. The liquid nitrogen cold insulation mechanism includes a central inner cylinder, the central rotating shaft is rotatably provided on the upper part of the central inner cylinder, and a nitrogen ejection port and a liquid supply tube are respectively provided at the upper end and the lower end of the central inner cylinder. The biological sample honeycomb type storage tank according to claim 7, 8, 9, 10, or 11, characterized in that.

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