Gas generating patch

Abstract

A gas generating patch capable of gradually releasing medical gas is provided. [Solution] A gas generating patch 100 includes a first layer 110, a plurality of porous carriers 120, and a reactant 130. According to one embodiment of the present invention, the reactant 130 is provided in the pores of the plurality of porous carriers 120, and the plurality of porous carriers 120 are provided on a surface of the first layer 110. In another embodiment of the present invention, the gas generating patch further includes a colloid provided on a surface of the first layer, and the plurality of porous carriers are uniformly dispersed within the colloid. In another embodiment of the present invention, the gas generating patch further includes a second layer provided on the plurality of porous carriers relative to the first layer.

Description

[Technical field]

[0001] The present invention relates to a medical patch, and more particularly to a gas generating patch capable of sustained release of a medical gas. [Background technology]

[0002] The use of gas to treat various diseases and conditions is a widely used medical technique. Common medical gases include oxygen gas, hydrogen gas, carbon dioxide, nitric oxide, laughing gas, nitrogen oxide, etc., and appropriate gas therapy can be provided to patients through medical devices such as breathing masks, nasal intubations, tracheal intubations, and artificial ventilators.

[0003] However, these medical devices are not only large in size and energy-intensive, but also have potential safety risks associated with the provision of medical gases through high-pressure gas cylinders, and the use of these medical devices requires operation and supervision by trained medical professionals, resulting in significant limitations in the practical application of gas therapy.

[0004] In view of the above, there is a need in the art for a medical product that is simple and safe to operate and can reliably provide gas therapy anywhere, anytime. Summary of the Invention

[0005] This summary is intended to provide a simplified summary of the disclosure to provide the reader with a basic understanding of the disclosure. This summary is not an extensive overview of the disclosure and is not intended to identify key / critical elements of embodiments of the invention or to delineate the scope of the invention.

[0006] The present invention provides a gas generating patch that generates gas by reacting with ambient water. According to one embodiment of the present invention, the gas generating patch includes a first layer, a plurality of porous carriers, and a reactant. The first layer is made of a first polymer. The first polymer is selected from the group consisting of polyethylene (PE), polyurethane (PU), polyethylene terephthalate (PET), and polypropylene (PP). The plurality of porous carriers are provided in a dispersed manner on the surface of the first layer. Each porous carrier has a plurality of pores. The reactant is provided in each pore of the porous carrier, and includes a metal peroxide and a metal hydroxide. The gas generated by the reactant reacting with the ambient water diffuses in the opposite direction to the first layer.

[0007] In one embodiment of the present invention, the gas is hydrogen gas and oxygen gas.

[0008] According to some embodiments of the present invention, the porous support is made of diatomaceous earth, PE, ethylene-vinyl acetate, or a combination thereof.

[0009] According to one embodiment of the present invention, each pore has a pore size of 1,200-6,000 nm.

[0010] According to some preferred embodiments of the present invention, the surface of the porous carrier is coated with an acid catalyst. In one embodiment of the present invention, the acid catalyst is selected from the group consisting of citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid and silicic acid.

[0011] According to an alternative embodiment of the present invention, the gas generating patch further comprises a second layer disposed on a plurality of porous carriers relative to the first layer, the second layer having a plurality of vent holes. In an exemplary embodiment of the present invention, the second layer is made of a second polymer selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate, and polypropylene, respectively.

[0012] In another alternative embodiment of the present invention, the gas generating patch further comprises a colloid disposed on the surface of the first layer and covering the plurality of porous carriers. The plurality of porous carriers are uniformly dispersed within the colloid. In one embodiment of the present invention, the plurality of porous carriers are present in the colloid in an amount of 5 wt%-70 wt% by weight.

[0013] Optionally, the colloid is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid (PAA), nitrocellulose, silica gel, collagen fiber, and algin.

[0014] According to some embodiments of the invention, the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide and barium peroxide. The metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide and barium hydroxide. According to some embodiments of the invention, the metal peroxide is calcium peroxide and the metal hydroxide is calcium hydroxide.

[0015] In non-required embodiments of the invention, the reactants further include carbonates, dioxidonitrates, and combinations thereof.

[0016] By referring to the following embodiments, those having ordinary skill in the art to which the present invention pertains can easily understand the basic spirit and other objects of the present invention, as well as the technical means and embodiments adopted by the present invention. [Brief description of the drawings]

[0017] In order to make the above contents and other objects, features, advantages and embodiments of the present invention more comprehensible, the accompanying drawings are described below. [Figure 1A] FIG. 1 is a schematic diagram showing the layout of a gas-generating patch 100 according to one embodiment of the present invention. [Figure 1B] 1B is a cross-sectional view of the gas-generating patch 100 of FIG. 1A. [Diagram 2] 1B is an enlarged schematic diagram of the porous carrier 120 in the gas-generating patch 100 of FIG. 1A. [Diagram 3] 3A and 3B are schematic diagrams of configurations of gas-generating patches 300a and 300b, respectively, according to different embodiments of the present invention. [Figure 4] 4A and 4B are 4-hour and 12-hour gas generation curves, respectively, of a gas generation patch according to the present invention.

[0018] In accordance with common practice, the various features and components in the figures are not drawn to scale, but are drawn in a manner intended to best illustrate the particular features and components relevant to the present invention. Furthermore, the same or similar reference numerals may be used in different drawings to denote similar parts / components.

[0019] In order to provide a more detailed and complete description of the present invention, the following description will be illustrative of the embodiments and specific examples of the present invention, which are not the only ways to implement or use the specific examples of the present invention. The embodiments include many of the features of the specific examples, as well as the steps and sequences for constructing and operating these specific examples. However, other examples may achieve the same or equivalent functions and steps.

[0020] I definition For convenience, certain terms used in the specification, examples, and appended claims are collected here. Unless otherwise defined herein, scientific and technical terms used herein have the same meaning as commonly understood and commonly used by those skilled in the art to which the present invention belongs. In addition, singular nouns used herein shall include the plural form of the noun, unless the context indicates otherwise, and plural nouns used shall include the singular form of the noun. Specifically, in this specification and claims, the singular forms a and an include plural references, unless the context indicates otherwise. Also, in this specification and patent application, the terms "at least one" and "one or more" are synonymous, each referring to one, two, three or more, or a multiplicity.

[0021] Although the numerical ranges and parameters used to define the broader scope of the present invention are approximations, the relevant numerical values ​​in the specific examples are shown as precisely as possible. However, any numerical value inherently includes a standard deviation resulting from the particular testing method used. Here, "about" usually means that the actual value is within plus or minus 10%, 5%, 1%, or 5% of the specified value or range. Alternatively, the term "about" means that the actual value falls within an acceptable standard error of the mean as determined by one of ordinary skill in the art to which the present invention pertains. Except in the experimental examples, or unless otherwise indicated, all ranges, amounts, numbers, and percentages used herein (such as to describe amounts of materials, lengths of time, temperatures, operating conditions, quantitative ratios, and other similar matters) are all modified by "about". Thus, unless specifically stated to the contrary, the numerical parameters disclosed in this specification and the appended claims are approximations and can be modified as necessary. At the very least, these numerical parameters should be understood to mean values ​​that can be obtained by applying the number of significant digits indicated and ordinary rounding techniques. Numeric ranges herein are expressed from one endpoint to the other endpoint, or between both endpoints, and unless otherwise specified, the numerical ranges herein include the endpoints.

[0022] In this specification, "ambient water" refers to water that exists as a gas in the environment, and may be water vapor present in the air or water vapor emitted by living organisms. For example, it may refer to water vapor generated by the evaporation of sweat from the human body in a hot environment or after activity. In this specification, "ambient water" refers to water generated by living organisms in a sealed space (e.g., a microspace between the patch and the skin, or a space between the mask and the mouth) formed after the gas-generating patch is attached to the skin surface of the user or wrapped around a specific part of the body.

[0023] As used herein, the term "venthole" refers to an open or permeable pore structure that allows gas and / or liquid to selectively pass through depending on the size, shape, density and distribution of the pores. Vents are commonly used in textiles, packaging, medical supplies (e.g., bandages and masks), building materials (e.g., breathable bricks), etc. The gas-generating patch of the present invention is provided with vents that allow only gas to pass through, thereby controlling the humidity in the gas-generating patch and thereby controlling the rate of gas generation.

[0024] II. Specific embodiments In order to solve the time and space limitations of production of treatment devices in the current gas treatment field, the present invention provides a gas-generating patch that patients can operate by themselves outside of medical institutions according to a doctor's prescription after receiving simple instructions, and can receive stable gas treatment for a long period of time without affecting their life and work schedules, thereby obtaining the best results.

[0025] The present invention aims to provide a gas generating patch that is applied to the skin or respiratory system of a user, and reacts with the surrounding moisture in the enclosed space to generate a specific gas having a therapeutic effect, thereby providing the required gas therapy. For example, a user can apply the gas generating patch to the arm, torso, face, or leg according to the need of use to form an enclosed space, and the specific gas can be generated in the enclosed space by reacting with the water vapor generated by the evaporation of sweat, establishing an internal partial pressure sufficient for a physiological response, and the gas can be delivered through the skin or respiratory system by a transdermal drug delivery system to achieve the purpose of local or systemic treatment.

[0026] FIG. 1A is a schematic diagram of a gas generating patch 100 according to an embodiment of the present invention. FIG. 1B is a cross-sectional view of the gas generating patch 100 of FIG. 1A. FIG. 2 is an enlarged schematic diagram of a porous carrier 120 on the gas generating patch 100 of FIG. 1A. As shown in FIGS. 1A, 1B, and 2, the gas generating patch 100 structurally includes a first layer 110 made of a first polymer having surfaces 111 and 112, a plurality of porous carriers 120 dispersed on the surface 111 of the first layer 110 having a plurality of pores 121, and a reactant 130 provided in these pores 121.

[0027] When the gas-generating patch 100 is attached to the skin surface of the user, specifically, the porous carrier 120 comes into contact with the user's skin, and the first layer 110 covers the porous carrier 120 and a part of the skin, thereby forming a sealed space at the affected area. The gas generated by the gas-generating patch 100 accumulates in the sealed space and gradually reaches a predetermined gas concentration, and the gas diffuses into the tissue due to the gas partial pressure force. In order to achieve the above object, the first layer 110 is made of a material (i.e., a first polymer) that is neither breathable nor waterproof, thereby forming a sealed space. In addition, since the gas-generating patch 100 of the present invention generates a target gas by reacting the surrounding moisture with the reactant 130, the first layer 110 must also have waterproof properties in order to control the reaction rate and prevent excess moisture from entering from the surface 112 and coming into contact with the reactant 130. Thus, in order to meet the demand for waterproofing and airtightness, in an embodiment of the present invention, the first polymer is selected from the group consisting of PE, PU, ​​PET and PP. In a specific embodiment of the present invention, the first polymer is PU. In another embodiment, the first polymer is PE. Optionally, the first layer 110 may be made of a laminated nonwoven fabric, which is a waterproof and gas-barrier fabric layer formed by bonding the first polymer to a nonwoven fabric by a method such as adhesion or hot pressing. Examples include PP laminated nonwoven fabric or PE laminated nonwoven fabric.

[0028] In a preferred embodiment, a plurality of porous carriers 120 are actually provided in a central portion of the first layer 110 (e.g., as shown in FIG. 1 ), such that the edge of the surface 111 of the first layer 110 can be directly attached to the skin and ensure that the generated therapeutic gas does not leak into the air from the edge of the gas-generating patch 100.

[0029] As shown in FIG. 2, in order to allow the gas generating reaction to proceed smoothly, the porous material has many pores 121 and the pores 121 are connected to each other. A natural or artificial porous material is used as a carrier (i.e., porous carrier 120) of the gas generating patch 100 of the present invention to support a reactant for gas generation (i.e., reactant 130), or the reactant 130 is applied to the porous carrier 120 to aggregate different reactants 130. In this way, each porous carrier 120 can form an independent reaction system. The structure of the pores 121 of the porous carrier 120 can have the effect of controlling the reaction rate by making it difficult for moisture to come into contact with the reactant 130.

[0030] The porous support 120 may be selected from any natural or artificial porous material known in the art and unreactive with the reactant 130 of the present invention. In an embodiment of the present invention, the porous support 120 is made of diatomaceous earth, PE, vinyl acetate copolymer, or a combination thereof.

[0031] Gases that can be produced by the gas generating patch 100 of the present invention and can be applied in the medical field to achieve a specific therapeutic effect include, but are not limited to, oxygen gas, carbon dioxide, hydrogen gas, nitric oxide, nitrous oxide, helium, nitrogen dioxide, etc. According to one embodiment of the present invention, the gas generating patch 100 of the present invention can generate hydrogen gas and oxygen gas. In another embodiment of the present invention, the reactant 130 can generate carbon dioxide and / or nitric oxide in addition to hydrogen gas and oxygen gas. Those skilled in the art can select the reactant 130 and provide suitable catalysts and reaction conditions (e.g., hydrogen ion potential) so that the gas generating patch 100 can generate the desired gas according to actual needs (e.g., the type of disease to be treated and the condition of the individual).

[0032] According to an embodiment of the present invention, the reactant 130 includes a metal peroxide and a metal hydroxide for reacting with surrounding moisture to generate oxygen gas and hydrogen gas, respectively. According to some embodiments of the present invention, the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide, and barium peroxide, and the metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, and barium hydroxide. Those skilled in the art can select specific metal peroxides and metal hydroxides according to actual needs. For example, when a relatively large amount of oxygen gas and / or hydrogen gas is to be generated, a peroxide or hydroxide containing a relatively highly active metal (e.g., sodium or potassium) can be used as a reactant.

[0033] Furthermore, the metal peroxide and metal hydroxide may be peroxides and hydroxides containing the same or different metals, for example, magnesium peroxide may be the metal peroxide and calcium hydroxide may be the metal hydroxide. In one embodiment of the present invention, the metal peroxide and metal hydroxide contain the same metal (i.e., calcium) and are calcium peroxide and calcium hydroxide, respectively.

[0034] According to a specific embodiment of the present invention, the reaction mechanism of generating oxygen gas from the reactant 130 is shown in Formula I or Formula II. The reaction mechanism of generating hydrogen gas is shown in Formula III or Formula IV. In the formula, X is a divalent metal such as calcium, magnesium, etc., and Y is a monovalent metal such as sodium, potassium, etc. As shown in Formula I or Formula II, the metal peroxide reacts with moisture to generate oxygen gas. As shown in Formula III or Formula IV, the metal hydroxide reacts with moisture and aluminum powder to generate hydrogen gas. 2XO2+2H2O→2X(OH)2+O2 (Formula I) 2Y2O2+2H2O→4Y(OH)+O2 (formula II) X(OH)2+2Al+6H2O→X(Al(OH)4)2+3H2 (formula III) 2Y(OH)+2Al+2H2O→2YAlO2+3H2 (formula IV)

[0035] As shown in formulas I-IV, metal peroxides can generate oxygen gas and metal hydroxides by reacting with moisture. Metal hydroxides can generate hydrogen gas by reacting with water. Therefore, by selecting appropriate metal peroxides and metal hydroxides, the hydrogen generation and oxygen generation processes can be a series of reactions, and the gas generation efficiency of the chemical reactant 130 can be optimized.

[0036] In another embodiment of the present invention, based on the reaction principle of the formulae III and IV, the reactions of the formulae III and IV can be carried out by using silicon, magnesium, or iron instead of aluminum to generate hydrogen gas.

[0037] Optionally, the reactant 130 of the present invention may further include carbonates, nitrites, and combinations thereof to generate carbon dioxide and / or nitric oxide.

[0038] As described above, the gas generating patch 100 of the present invention can provide various therapeutic gases through various gas generating reactions. In order to avoid unwanted reactions between different reactants and products, different reactants 130 are provided in different porous carriers 120, so that each porous carrier 120 is an independent gas generating system. For example, each porous carrier 120 may be an oxygen generating system (i.e., a porous carrier containing a metal peroxide), a hydrogen generating system (i.e., a porous carrier containing a metal hydroxide), a carbon dioxide generating system (i.e., a porous carrier containing a carbonate), and a nitric oxide generating system (i.e., a porous carrier containing a nitrite). However, based on the reaction mechanisms of oxygen generation and hydrogen generation as described above (i.e., formulas I-IV), the oxygen generating system and the hydrogen generating system can be combined, i.e., a metal peroxide and a metal hydroxide are provided in the same porous carrier, so that the gas generating efficiency of the gas generating patch 100 can be optimized.

[0039] In some embodiments of the present invention, the pores 121 on the porous support 120 preferably have a pore size of 1,200-6,000 nm to support the reactant 130. The porous support 120 may be in the form of a sheet, granules, irregular shape, or any structure that does not affect the occurrence of the reaction or inhibit the ingress of moisture.

[0040] Optionally, an acid catalyst is further applied to the surface of the porous support 120 to adjust the pH of the reaction environment in the porous support 120. The pH may be maintained between 4-9. The acid catalyst applied to the porous support 120 of the present invention includes, but is not limited to, citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid and silicic acid. According to one embodiment of the present invention, the acid catalyst is citric acid.

[0041] In an alternative embodiment of the present invention, the purpose of maintaining the pH may be achieved by adding a solid acid to the reactant 130. The solid acid includes solid citric acid, solid lactic acid, solid phytic acid, solid oxalic acid, solid hydrochloric acid, solid silicic acid, etc.

[0042] When the gas-generating patch 100 of the present invention is stored, it can be packaged in an airtight material to prevent moisture in the air from coming into contact with the reactant 130. When in use, the airtight packaging is removed and the gas-generating patch 100 is simply applied to the affected area, whereupon the gas-generating patch 100 reacts with water vapor evaporated from the body surface and supplies gas to the skin in a specific direction (i.e., the opposite direction to the first layer 110).

[0043] 3A and 3B are schematic diagrams of the layout of layered structures of gas-generating patches 300a and 300b, respectively, according to two different embodiments of the present invention.

[0044] As shown in FIG. 3A, the gas generating patch 300a has almost the same arrangement as that of the gas generating patch 100. Specifically, the gas generating patch 300a includes a waterproof and breathable first layer 310a and a plurality of porous carriers 320a provided on a surface 311a of the first layer 310a. The pores of the porous carrier 320a contain a reactant 330a that generates gas. The gas generating patch 300a differs from the gas generating patch 100 in that the colloid 340 is provided on the same surface of the first layer 310a as the plurality of porous carriers 320a, and in this case, the plurality of porous carriers 320a are uniformly dispersed in the colloid 340.

[0045] The colloid 340 is a particle suspended in a continuous medium, which interacts with one another to form a special material state having pores, so that the porous carrier 320a is encapsulated in the colloid 340, and the pores of the colloid 340 can be used to control the contact speed between the moisture and the reactant 330a, thereby controlling the rate of gas generation and achieving the purpose of slow gas release.

[0046] The material of the colloid 340 can be selected according to the common knowledge in the art. The colloid 340 may be an oil-based or aqueous colloid formed of an organic or inorganic polymer. According to some embodiments of the present invention, the colloid 340 is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid, nitrocellulose, silica gel, collagen fiber, and algin. In order to avoid the reaction between the reactant 330a and the water in the colloid 340, it is preferable that the colloid is formed by coating the porous carrier 320a, for example, nitrocellulose or silica gel and glycerin, with an oil-based colloid.

[0047] In one embodiment of the invention, the porous support 320a is present in the colloid 340 in an amount of 5 wt%-70 wt%. For example, the porous support 320a is present in the colloid 340 in an amount of 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70% by weight.

[0048] 3B is a schematic diagram of the layered structure of a gas generating patch 300b according to another embodiment of the present invention. As shown in FIG. 3B, the gas generating patch 300b includes a first layer 310b, a plurality of porous carriers 320b provided on a surface 311b of the first layer 310b, and a reactant 330b provided in the pores of the porous carrier 320b. The gas generating patch 300b is different from the above gas generating patch 100 or 300a in that it further includes a second layer 350 provided on the plurality of porous carriers 320b with respect to the first layer 310b. In other words, in the gas generating patch 300b, the plurality of porous carriers 320b are provided between the first layer 310b and the second layer 350.

[0049] The second layer 350 (FIG. 3B) of the gas-generating patch 300b and the colloid 340 (FIG. 3A) of the gas-generating patch 300a are both intended to control the contact rate between the water vapor and the reactant. Therefore, the second layer 350 has a number of vent holes 351 through which water vapor can enter and the generated gas can diffuse to the surface of the user's body.

[0050] In order to avoid liquid water coming into contact with the reactant 330b through the second layer 350 and causing a rapid gas reaction, the second layer 350 is preferably made of a second polymer having waterproof properties and has a structure of a plurality of air holes 351 on a microscopic scale according to the common knowledge in the art. The second polymer applied to the second layer 350 of the present invention includes, but is not limited to, PE, PU, ​​PET or PP. Those skilled in the art should understand that the list of some suitable polymers is merely exemplary and does not limit the material for manufacturing the second layer 350. Furthermore, since one surface of the second layer 350 contacts the skin of the user, the second layer 350 may be made of a waterproof, breathable and skin-friendly material.

[0051] Working Example Example 1: Preparation of a gas-generating patch according to the present invention In order to measure the gas generation efficiency of multiple independent gas generation systems, PU was selected as the first polymer (i.e., the material of the first layer), the porous carrier was made of diatomaceous earth, potassium peroxide and calcium hydroxide were used as reactants for hydrogen generation and oxygen generation, respectively, and citric acid was applied to the porous carrier, thereby manufacturing the gas generation patch of the present invention.

[0052] Example 2: Analysis of the gas generating efficiency of the gas generating patch of the present invention

[0053] The gas-generating patch of the present invention prepared in Example 1 and a dropper containing 5 ml of water were placed in a sealed container, and a negative pressure of -0.2 kg / cm was applied. 2 By drawing a vacuum to 100°C, the water in the dropper flowed out and turned into water vapor, and the water vapor reacted with the gas-generating patch to generate gas.

[0054] 2.1 Total gas generation The total amount of gas generated from the gas generating patch of the present invention was measured by the water displacement method. The results are shown in Table 1. Table 1: Changes in oxygen gas concentration in a sealed container [Table 1]

[0055] As can be seen from the results in Table 1, the total amount of gas generated by the gas generating patch of the present invention within 40 minutes was 4 ml.

[0056] 2.2 Gas generation efficiency The gas generation test was carried out for 4 hours and 12 hours for the gas generation patch of Example 1. During the test, the concentrations of oxygen gas and hydrogen gas in the container were measured and recorded every 10 minutes using a handheld oxygen gas analyzer and a handheld hydrogen gas analyzer, respectively. The results are shown in Figures 4A and 4B.

[0057] Fig. 4A shows the change curves of oxygen and hydrogen gas concentrations in the vessel over 4 hours. As can be seen from Fig. 4A, the initial oxygen content in the vessel was 16.23%, and the oxygen content after the reaction was 17.72%, and the total oxygen generation amount after conversion was about 16,400 ppm, the average oxygen generation rate was 68.3 ppm / min, the total hydrogen generation amount was about 70.7 ppm, and the average hydrogen generation rate was 0.3 ppm / min.

[0058] The concentrations of oxygen gas and hydrogen gas in the container both increased slowly over a four-hour period, indicating that the gas-generating patch of the present invention can stably release oxygen gas and hydrogen gas for a long period of time within four hours.

[0059] Fig. 4B shows the change curves of oxygen and hydrogen gas concentrations in the vessel over 12 hours. As can be seen from Fig. 4B, the initial oxygen content in the vessel was 13.61%, and the oxygen content after the reaction was 17.72%, and the total oxygen generation amount after conversion was about 49,200 ppm, the average oxygen generation rate was 68.3 ppm / min, the total hydrogen generation amount was about 165.6 ppm, and the average hydrogen generation rate was 0.23 ppm / min.

[0060] The concentrations of oxygen gas and hydrogen gas in the container both gradually increased over the 12 hours, indicating that the gas generating patch of the present invention can stably release oxygen gas and hydrogen gas for a long period of time within 12 hours.

[0061] In view of the above, the present invention provides a gas-generating patch that allows patients to undergo gas therapy outside of medical facilities without being restricted by time and space, can be attached to different areas according to the needs of the user, and achieves the purpose of gradually releasing the required therapeutic gas by limiting the contact speed between the reactant and moisture using a colloid or a film with air holes, thereby providing an effective therapeutic effect.

[0062] It should be understood that the above description of the embodiments is given by way of example only, and various modifications may be made by those skilled in the art. The above specification, examples, and experimental results provide a complete description of the structure and application of the exemplary embodiments of the present invention. Various examples of the present invention are disclosed in the above embodiments, but are not intended to limit the present invention. Those skilled in the art may make various changes and modifications without departing from the principle and spirit of the present invention, and therefore the protection scope of the present invention shall be determined by the attached patent application.

[0063] Explanation of symbols 100, 300a, 300b Gas Generating Patch 110, 310a, 310b 1st layer 111, 112, 311a, 311b surface 120, 320a, 320b Porous carrier 121 Pore 130, 330a, 330b Reactants 340 Colloid 350 2nd layer 351 Ventilation hole

Claims

1. A gas generating patch that generates gas in response to ambient water, the patch comprising a first layer, a plurality of porous carriers, and a reactant; The first layer is made of a first polymer, and the first polymer is selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate, and polypropylene; The plurality of porous carriers are provided in a dispersed manner on a surface of the first layer, and each of the porous carriers has a plurality of pores; The reactants are provided in each of the pores, and the reactants include a metal peroxide and a metal hydroxide. A gas generating patch, wherein the gas generated by the reaction of the reactant with the surrounding moisture diffuses in a direction opposite to the first layer.

2. 2. The gas generating patch of claim 1, wherein the gas is hydrogen gas and oxygen gas.

3. 2. The gas generating patch of claim 1, wherein each of said pores has a pore size of 1,200-6,000 nm.

4. 2. The gas generating patch according to claim 1, wherein the plurality of porous carriers are made of diatomaceous earth, polyethylene, ethylene-vinyl acetate, or a combination thereof.

5. The gas generating patch of claim 1 , wherein an acid catalyst is applied to a surface of each of said porous carriers.

6. 6. The gas generating patch of claim 5, wherein the acid catalyst is selected from the group consisting of citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid and silicic acid.

7. 2. The gas generating patch of claim 1, further comprising a second layer, the second layer being disposed relative to the first layer on the plurality of porous carriers, the second layer having a plurality of vent holes, the plurality of porous carriers being disposed between the first layer and the second layer in the gas generating patch.

8. 8. The gas generating patch of claim 7, wherein the second layer is made of a second polymer, the second polymer being selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate, and polypropylene, respectively.

9. 2. The gas generating patch of claim 1, further comprising a colloid provided on said surface of said first layer and covering said plurality of porous carriers, said plurality of porous carriers being uniformly dispersed within said colloid.

10. 10. The gas generating patch of claim 9, wherein said plurality of porous carriers are present in said colloid in an amount of 5 wt %-70 wt % by weight.

11. 10. The gas generating patch according to claim 9, wherein the colloid is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid, nitrocellulose, silica gel, collagen fiber, and algin.

12. 2. The gas generating patch according to claim 1, wherein the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide, and barium peroxide, and the metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, and barium hydroxide.

13. 13. The gas generating patch of claim 12, wherein said metal peroxide is calcium peroxide and said metal hydroxide is calcium hydroxide.

14. 10. The gas generating patch of claim 1, wherein the reactant further comprises a carbonate, a nitrite, and combinations thereof.

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