Disposable cartridge, system, and method for electrostatic applicators - Patents.com

Abstract

A disposable fluid delivery system for an electrostatic applicator. The system includes a nozzle housing with an air supply port, a voltage port, and a delivery outlet. The voltage wire has a contact in communication with a delivery tube in fluid communication with the delivery outlet. The syringe includes a barrel portion and a plunger configured to advance fluid from within the barrel portion through the delivery tube. A cartridge housing can at least partially enclose the nozzle housing, the voltage wire, and the syringe.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to and the benefit of U.S. Provisional Patent Application No. 63 / 411,334, filed September 29, 2022, and U.S. Nonprovisional Patent Application No. 18 / 110,854, filed February 16, 2023, the contents of each of which are incorporated by reference in their entirety as if fully set forth below.

[0002] The solutions of the present disclosure relate to devices, systems, and methods for applying one or more pharmaceutical agents (e.g., one or more biologics, polymer spun wound dressings, antiseptics, or anesthetics) to a treatment site (e.g., a wound surface of a subject). More specifically, the devices, systems, and methods are directed to an electrostatic applicator device with disposable cartridges for housing various solutions. [Background technology]

[0003] Infectious diseases are frequently transmitted in places that should be safe, such as ambulances, hospitals, clinical settings, and other areas such as assisted living facilities. Indeed, these healthcare associated infections (HAIs) pose a significant threat to patient safety and cause unnecessary economic burdens. For example, surgical site infections, which contribute significantly to HAIs, can not only cause pain and discomfort to patients, but can also lead to prolonged and / or repeated hospitalizations. A large number of antibacterial and / or analgesic compounds are available that can help treat patients and avoid infections. However, despite the prevalence of these compounds, current delivery methods often lack efficacy.

[0004] For example, oral and intravenous administration is often insufficient to effectively control or treat severe pain in certain regions of the human body, and high doses can lead to adverse events. To overcome some of the problems associated with oral and intravenous administration, delivery vehicles such as hydrogels have been developed to provide spatial and temporal control over the release of various therapeutic agents, including small molecule drugs, peptides, and cells. However, hydrogels can also have certain undesirable properties, including being expensive and difficult to sterilize.

[0005] More recently, electrospraying has emerged as a technology with potential biomedical applications. Electrospraying involves providing an electrostatic charge to the fluid as it is discharged from an electrostatic sprayer. The electric field can cause the discharged liquid to break up into small droplets, e.g., on the order of microns, which can be relatively uniformly attached to the treatment site with less solution. That said, not all solutions, including disinfectants and / or analgesics, respond equally to the same electrostatic conditions, and differences in the viscosity and / or dielectric properties of the solutions may require different optimal configurations for the electrostatic sprayer device. Current electrostatic sprayer devices do not provide a modular system that can accommodate a variety of different solutions within one electrostatic sprayer device.

[0006] The present disclosure solves these and other problems in the art. Summary of the Invention

[0007] The subject of the present disclosure is an electrostatic applicator for expelling contents from a disposable cartridge (eg, a treatment solution contained therein) to a treatment site on a patient.

[0008] In some examples, a disposable fluid delivery system for an electrostatic applicator is disclosed. The system can include a nozzle housing including an air supply port, a voltage port, and a delivery outlet. The voltage wire can include a contact in communication with a delivery tube in fluid communication with the delivery outlet, the voltage wire in electrical communication with a high voltage module and configured to electrostatically charge fluid contents within the delivery tube. The syringe can include a barrel portion and a plunger configured to advance fluid from within the barrel portion through the delivery tube. A cartridge housing can at least partially enclose the nozzle housing, the voltage wire, and the syringe.

[0009] In some examples, the voltage tube is in electrical communication with the voltage port, and a voltage wire passes between a contact in communication with the delivery tube and a contact port in the wall of the cartridge housing.

[0010] In some examples, the voltage tube and the voltage wire include a generally S-shape.

[0011] In some examples, the voltage tubes and voltage wires include a generally curved shape.

[0012] In some examples, the voltage tubes and voltage wires include straight shapes.

[0013] In some examples, the syringe contains a fluid including one or more of an antiseptic, a germicidal solution, a pain reliever, an exosome, a biologic, and / or a liquid dressing solution.

[0014] In some instances, the analgesic includes one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime.

[0015] In some examples, the biologic comprises one or more of stem cells and / or mammalian cells.

[0016] In some instances, the cartridge housing is a moldable plastic material.

[0017] In some examples, the cartridge housing includes multiple sections of moldable plastic that can be connected to create a single integral component.

[0018] In some examples, the voltage wire contact comprises a wire loop that at least partially surrounds the exterior surface of the delivery tube to provide a potential of about 1 V to about 40 kV.

[0019] In some examples, the contacts of the voltage wire are in physical contact with the exterior surface of the delivery tube to provide a potential of about 1 V to about 40 kV.

[0020] In some examples, when assembled with the syringe and nozzle housing, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and expel fluid that is uniformly charged by the voltage wire.

[0021] In some examples, the disposable cartridge includes an air delivery tube connected to the air delivery port.

[0022] In some examples, the system includes a reusable electrostatic applicator including a cartridge chamber sized and shaped to receive the cartridge housing, the reusable electrostatic applicator including a high voltage module configured to be in electrical communication with the voltage wires. A piston can be disposed proximate to the cartridge chamber and configured to advance a plunger enclosed within the cartridge housing when the cartridge housing is assembled with the cartridge chamber.

[0023] In some examples, the reusable electrostatic applicator includes a motor configured to move a piston, one or more processors, and memory storing instructions that, when executed by the one or more processors, cause the reusable electrostatic applicator to receive an activation signal, output a control signal to the motor to actuate the piston, and output a control signal to a switch to supply voltage from the high voltage module to a voltage wire.

[0024] In some examples, the motor is a stepper motor, a linear actuator, a worm gear motor, and / or a planetary gear motor.

[0025] In some examples, a motor is a drivable actuator system that uses motion transmission through an applied force.

[0026] In some examples, the reusable electrostatic applicator includes a display screen and the activation signal is a user input to the display screen.

[0027] In some examples, the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator.

[0028] In some examples, the reusable electrostatic applicator includes a housing base including a voltage source, a device housing including a cartridge chamber, and a handle extending between the housing base and the device housing.

[0029] In some examples, the cartridge chamber is positioned within the device housing such that the actuator is located below the cartridge chamber relative to the horizontal.

[0030] In some examples, the reusable electrostatic applicator includes a wireless antenna and the activation signal is a wireless signal received from a remote external user device.

[0031] In some examples, an electrostatic applicator system for delivering a treatment solution to a target site is disclosed. The system can include a portable, reusable electrostatic applicator including a device housing configured to be handheld, a motor in the device housing configured to drive a piston, a voltage source in the device housing, a high voltage module electrically connected to the voltage source, and a cartridge chamber. A disposable cartridge is removably insertable into the cartridge chamber, the disposable cartridge including a nozzle housing including an air supply port, a voltage port, and a delivery outlet. A voltage wire is provided with contacts in communication with a delivery tube in fluid communication with the delivery outlet. A syringe is provided with a barrel portion and a plunger configured to advance a fluid distally from within the barrel portion through the delivery tube. A cartridge housing is included that at least partially surrounds the nozzle housing, the voltage wire, and the syringe.

[0032] In some examples, the voltage wires and voltage tubes include voltage wires that include straight and / or curved or generally S-shaped configurations within the cartridge housing.

[0033] In some instances, the cartridge housing is a moldable plastic material.

[0034] In some examples, the cartridge housing includes multiple connected sections of moldable plastic.

[0035] In some examples, the cartridge chamber includes a wall including a high voltage contact in electrical communication with the high voltage module and an air supply port in fluid communication with a pump disposed within the device housing. A voltage wire can be in electrical communication with the high voltage contact in the wall. The contact of the voltage wire can be in physical contact with an exterior surface of the delivery tube to provide an electrical potential of about 1 V to about 40 kV.

[0036] In some examples, the HV module includes multiple rotating diodes such that the HV module is configured to generate both positive and negative high voltages depending on the orientation of the rotating diodes.

[0037] In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system.

[0038] In some examples, the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and expel fluid that is uniformly charged by the voltage wire.

[0039] In some examples, the device housing includes a handle, the voltage source is disposed within a housing base of the device housing, and the handle is disposed between the device housing and the housing base.

[0040] In some examples, the reusable electrostatic applicator includes one or more processors and memory storing instructions that, when executed by the one or more processors, cause the reusable electrostatic applicator to receive an activation signal and output control signals to motors that control (a) the electrical potential from a high voltage module via a voltage wire to a delivery tube, (b) the position of a piston and plunger of a disposable cartridge, and / or (c) a pump that regulates air flow from the device housing to an air supply port via an air supply tube.

[0041] In some examples, the disposable cartridge includes an on-chip memory containing information regarding operating parameters of contents stored in the syringe and / or another fluid reservoir of the disposable cartridge, and the one or more processors of the reusable electrostatic applicator are configured to communicate with the on-chip memory to obtain information regarding the contents of the disposable cartridge and to control at least one of the flow rate, electrical potential, and nozzle settings.

[0042] In some examples, the disposable cartridge includes an on-board memory that contains information regarding operating parameters of contents stored in the syringe and / or another fluid reservoir of the disposable cartridge. The one or more processors of the reusable electrostatic applicator are configured to communicate with the on-board memory to obtain information regarding the contents of the disposable cartridge and to control the motor speed, air intake, and / or applied voltage.

[0043] In some examples, the memory is incorporated into a processor of the electrostatic applicator system and includes operational instructions for operating the electrostatic applicator system.

[0044] In some examples, a Near Field Communication (NFC) tag includes a memory.

[0045] In some examples, the instructions further include reading information in the NFC regarding operating parameters of the disposable cartridge and displaying at least a portion of the NFC read information (e.g., content identity, volume, etc.) on a display screen. In some aspects, information can be written to the NFC by a processor of the electrostatic applicator system.

[0046] In some examples, the applicator includes a display screen and the activation signal is a user input to the display screen.

[0047] In some examples, the applicator includes an actuator and the activation signal is a user input received by the actuator.

[0048] In some examples, the applicator includes a communication system within the applicator's CPU. The communication system can include a wireless antenna (e.g., one or more transceivers can be compatible with a short-range wireless communication connection), and the activation signal is a wireless signal received from an external user device.

[0049] In some examples, the applicator includes an accelerometer configured to output a movement signal to the one or more processors in response to detecting movement of the electrostatic applicator system.

[0050] In some examples, the applicator includes a display screen on an electrostatic applicator system that is activated by a wake signal from the one or more processors in response to the one or more processors receiving a movement signal, the activation signal being a user input to the display screen.

[0051] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target. One of the control signals is output to a motor in response to the distance being within a predetermined distance threshold. In some examples, the predetermined distance threshold can be between about 2 inches and about 18 inches, but most preferably is between about 4 inches and about 6 inches. One of the control signals is output to a switch to control a voltage of the electrostatic applicator system in response to the distance being within the predetermined distance threshold.

[0052] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and the intended target, and one of the control signals is output to prevent operation of the motor in response to the distance being greater than or less than a predetermined distance threshold.

[0053] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and the intended target, and one of the control signals is output to the switch to prevent delivery of voltage of the electrostatic applicator system in response to the distance being greater than or less than a predetermined distance threshold.

[0054] In some examples, a method for operating an electrostatic applicator system is disclosed. The method can include inserting a first disposable cartridge into a chamber housing of the electrostatic applicator system such that a voltage contact at a first end of a voltage wire in the first disposable cartridge contacts a voltage contact of the electrostatic applicator system, a first end of an air supply port in the first disposable cartridge is in fluid communication with an air supply port of the electrostatic applicator system, and a plunger of a syringe containing a first fluid in the first disposable cartridge is aligned with a piston of the electrostatic applicator system. The method can include actuating a motor with an actuation input to the electrostatic applicator system and delivering an electrical potential to a delivery tube of the first disposable cartridge.

[0055] In some examples, actuating the motor and delivering an electric potential causes the first fluid to advance from the syringe through the delivery tube and spray as electrostatically charged atomized fluid droplets in a predetermined spray pattern onto the target site. In some embodiments, the target site may be oppositely charged relative to the droplets. In some embodiments, the maximum electric potential path may be between the target site and the charged droplets, although the target site may not be specifically oppositely charged.

[0056] In some examples, actuating the motor and delivering an electrical potential causes the first fluid to be advanced from the syringe through a delivery tube and sprayed onto an oppositely charged target site as electrostatically charged atomized fluid droplets carried in a predetermined spray pattern.

[0057] In some examples, the method can include removing a first disposable cartridge from the chamber housing and inserting a second disposable cartridge into the chamber housing, the second disposable cartridge containing a second fluid.

[0058] In some examples, the second disposable cartridge is configured for electrospinning. The method can include actuating a motor and delivering an electrical potential to a delivery tube of the second disposable cartridge by a second actuation input to the electrostatic applicator system such that a second fluid in a syringe of the second disposable cartridge is delivered from the second fluid to a target site (e.g., at a predetermined rate and / or release pattern) by a delivery tube of the second disposable cartridge as electrospun fibers. In some examples, the second fluid can suspend fibers therein before the electrospun fibers are formed.

[0059] In some examples, the first disposable cartridge and the second disposable cartridge each include an on-board memory containing information regarding operating parameters of the first fluid and the second fluid, respectively, and insertion of either the first disposable cartridge or the second disposable cartridge into the chamber housing causes the operating parameters to be transmitted to the memory of the electrostatic applicator system, the operating parameters including the motor speed, air intake, and voltage applied to the delivery tube of the respective disposable cartridge.

[0060] In some examples, the method may include, upon insertion of either the first disposable cartridge or the second disposable cartridge into the chamber housing, tagging a registry associated with information about operating parameters of the first disposable cartridge or the second disposable cartridge as being a used cartridge, and, upon determining that the first disposable cartridge or the second disposable cartridge is a used cartridge, actuating a motor and / or preventing an electrical potential from being delivered to a delivery tube of the first disposable cartridge or the second disposable cartridge.

[0061] In some examples, the first disposable cartridge and the second disposable cartridge contain different fluids.

[0062] In some examples, the first disposable cartridge and the second disposable cartridge include at least one of different voltage wires and different delivery tubes depending on the respective nozzle housing, the first fluid stored in the respective disposable cartridge, and / or the second fluid.

[0063] In some examples, providing the activation input includes inputting information about the first fluid to a display screen of the electrostatic applicator system and providing the input to the display screen.

[0064] In some examples, the method includes pairing the electrostatic applicator system to an external user device via a short-range wireless connection, and providing the activation input includes inputting information about the first fluid into the external user device and providing the input to a display screen of the external user device.

[0065] In some examples, a computer-implemented method for operating an electrostatic applicator system is disclosed, the method including: actuating a motor by an actuation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of the disposable cartridge removably attached to a chamber housing of the electrostatic applicator system, the motor biasing a plunger of the syringe to advance fluid contents of the disposable cartridge from the syringe through the delivery tube, electrostatically charging the fluid contents in the delivery tube by the voltage wire, and expelling the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site.

[0066] In some examples, the method can include electrostatically charging the fluid contents within a barrel portion of the syringe proximal to the delivery tube with a voltage wire.

[0067] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air supply of an electrostatic applicator system into the disposable cartridge to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto the target site.

[0068] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers.

[0069] In some examples, the method includes detecting a distance between the electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being within a predetermined distance threshold, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0070] In some examples, the method includes detecting a distance between the electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being greater than or less than a predetermined distance threshold, preventing operation of the motor and / or preventing the high voltage module from delivering an electrical potential.

[0071] In some examples, the method includes initiating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the movement signal, and in response to the wake signal, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0072] In some examples, the disposable cartridge includes an on-board memory that includes information regarding operating parameters of the fluid contents stored in the syringe. In this regard, the method can include communicating with the on-board memory, by one or more processors of the reusable electrostatic applicator, to obtain information regarding the fluid contents of the disposable cartridge, and controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including a motor speed, an air intake, and / or an applied voltage of the disposable cartridge.

[0073] In some examples, the memory is incorporated into a processor of the electrostatic applicator system and includes operating instructions for a computer-implemented method for operating the electrostatic applicator system.

[0074] In some examples, a system for operating an electrostatic applicator system is disclosed. The system can include at least one memory that stores instructions and at least one processor configured to execute the instructions to perform operations. In some embodiments, the operations can include: actuating a motor via an activation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system; the motor urging a plunger of the syringe to advance fluid contents of the disposable cartridge from the syringe through the delivery tube; electrostatically charging the fluid contents within the delivery tube via the voltage wire; and expelling the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site.

[0075] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air pump in the electrostatic applicator into the disposable cartridge to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto an oppositely charged target site.

[0076] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering electrospun fibers at a predetermined rate and / or pattern from the electrostatically charged fluid contents onto a target site having an electrical potential difference.

[0077] In some examples, the operation includes detecting a distance between the electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being within a predetermined distance threshold, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0078] In some examples, the operations include initiating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the movement signal, and in response to the wake signal, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0079] In some examples, the disposable cartridge includes an on-board memory that includes information regarding operating parameters of the fluid contents stored in the syringe. In this regard, the operations can include communicating with the on-board memory, by one or more processors of the reusable electrostatic applicator, to obtain information regarding the fluid contents of the disposable cartridge, and controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including a motor speed, an air intake, and / or an applied voltage of the disposable cartridge.

[0080] In some examples, the memory is incorporated into a processor of the electrostatic applicator system and includes operating instructions for a computer-implemented method for operating the electrostatic applicator system.

[0081] In some examples, a non-transitory computer-readable medium is disclosed that, when executed by a processor, causes the processor to perform a method for operating an electrostatic applicator system. The method can include actuating a motor via an activation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of the electrostatic applicator system that is removably attached to a chamber housing of the electrostatic applicator system, the motor urging a plunger of the syringe to advance fluid contents of the disposable cartridge from the syringe through the delivery tube, electrostatically charging the fluid contents within the delivery tube via the voltage wire, and expelling the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site.

[0082] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air supply of the electrostatic applicator system into the disposable cartridge to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto the oppositely charged target site. In some examples, the predetermined spray pattern can include droplets being repelled from other droplets while being drawn toward the similarly charged, oppositely charged target site. In some examples, the droplets can be positively charged and the target site can be negatively charged. In some examples, the droplets can be negatively charged and the target site can be positively charged.

[0083] In some examples, the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering electrospun fibers from the electrostatically charged fluid contents onto an oppositely charged target site at a predetermined rate and / or pattern.

[0084] In some examples, the method includes detecting a distance between the electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being within a predetermined distance threshold, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0085] In some examples, the method includes initiating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the movement signal, and in response to the wake signal, sending an activation input to operate a motor and / or to a high voltage module to deliver an electrical potential.

[0086] In some examples, the disposable cartridge includes an on-board memory that includes information regarding one or more operating parameters of the fluid contents stored in the syringe. The method can include communicating with the on-board memory, by one or more processors of the reusable electrostatic applicator, to obtain information regarding the fluid contents of the disposable cartridge, and controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control the one or more operating parameters of the disposable cartridge, where the one or more operating parameters include a motor speed, an air intake, and / or an applied voltage of the disposable cartridge.

[0087] To the accomplishment of the foregoing and related ends, certain illustrative aspects are described herein in connection with the following description and the annexed drawings. These aspects are indicative, however, of but a few of the various ways in which the principles of the claimed subject matter may be employed and it is intended that the claimed subject matter include all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description when considered in conjunction with the drawings.

[0088] The above and further aspects of the present invention are further explained with reference to the following description in conjunction with the accompanying drawings, in which like numerals indicate like structural elements and features in the various figures. The drawings are not necessarily to scale, emphasis instead being placed on illustrating the principles of the present invention. The figures depict one or more implementations of the device of the present invention by way of example only and not by way of limitation. [Brief description of the drawings]

[0089] [Figure 1A] 1 illustrates a perspective view of an exemplary base and an exemplary electrostatic applicator in a disassembled state. [Figure 1B] 1B illustrates a side view of an exemplary base and the exemplary electrostatic applicator of FIG. 1A in an exploded state. [Figure 1C]1B illustrates a side view of the exemplary electrostatic applicator of FIG. 1A mated with an exemplary base. [Figure 2A] 1A, 1B, and 1C with a disposable cartridge in an exploded state. FIG. [Figure 2B] 1A, 1B, and 1C with the disposable cartridge of FIG. 2A in an exploded state. FIG. [Diagram 3] 1B illustrates a side view of the exemplary electrostatic applicator of FIG. 1A with a portion of the outer housing removed. [Figure 4A] 1A, 1B, 1C, 2A, and 2B show front perspective views of the exemplary cartridges of FIG. [Figure 4B] 1A, 1B, 1C, 2A, and 2B show rear perspective views of the exemplary cartridges of FIG. [Figure 5A] 1A, 1B, 1C, 2A, and 2B show rear and bottom perspective views of the exemplary cartridges of FIG. [Figure 5B] 1A, 1B, 1C, 2A, and 2B with a portion of the outer housing removed. FIG. [Figure 5C] 1A, 1B, 1C, 2A, and 2B with the outer housing removed. FIG. [Figure 6] 1A, 1B, 1C, 2A, 2B, and 3 in a closed position with an electrostatic applicator; FIG. [Figure 7A] 4 illustrates an enlarged cross-sectional view of the exemplary embodiment of FIG. 3 showing a closure system within the intake and exhaust ports for the exemplary electrostatic applicator and exemplary cartridge. [Figure 7B] FIG. 7B is an enlarged cross-sectional view similar to FIG. 7A, but showing an exemplary valve seal in an open position. [Figure 8A] 1A, 1B, 1C, 2A, 2B, and 3. FIG. 1B shows a side cross-sectional view of an exemplary embodiment of the actuator shown in FIG. [Figure 8B] FIG. 1 shows a side cross-sectional view of another exemplary actuator that may be used in the previous examples of FIGS. 1A, 1B, 1C, 2A, 2B, and 3. [Figure 9A] FIG. 1 shows a front perspective view of an exemplary electrospinning cartridge that may be used with the exemplary electrostatic applicator of FIGS. 1A, 1B, 1C, 2A, 2B, and 3. [Figure 9B] FIG. 1 shows a rear perspective view of an exemplary electrospinning cartridge that may be used with the exemplary electrostatic applicator of FIGS. 1A, 1B, 1C, 2A, 2B, and 3. [Figure 10A] 9A and 9B show bottom and rear perspective views of the exemplary cartridge. [Figure 10B] 9A and 9B with a portion of the outer housing removed. FIG. [Figure 10C] 9C shows an exploded perspective view of the internal components of the exemplary cartridge of FIGS. 9A and 9B with the outer housing removed. FIG. [Figure 11A] FIG. 1 shows a perspective view of the internal components of an exemplary electrostatic cartridge that may be used in the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, and 3, the components including a pair of syringes and an electrostatic nozzle. [Figure 11B] 11B illustrates a side cross-sectional view of the exemplary internal components shown in FIG. 11A. [Figure 12A] FIG. 1 shows a perspective view of the internal components of an exemplary electrostatic cartridge that may be used in the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, and 3, the components including a pair of syringes, at least one electrostatic nozzle, and at least one electrospinning delivery tube. [Figure 12B] 12B illustrates a side cross-sectional view of the exemplary internal components shown in FIG. 12A. [Figure 13A]FIG. 1 shows a perspective view of the internal components of an exemplary electrostatic cartridge that may be used with the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, and 3, the components including a pair of syringes and an electrospinning delivery tube interconnected by a Y-shaped member. [Figure 13B] 13B illustrates a side cross-sectional view of the exemplary internal components shown in FIG. 13A. [Figure 14A] 1 illustrates a side perspective view of an exemplary cone configured for use with any of the nozzles disclosed herein of the described disposable cartridge. [Figure 14B] 13 shows a side perspective view of another exemplary cone configured for use with any of the nozzles disclosed herein of the described disposable cartridge. [Figure 14C] 13 shows a side perspective view of another exemplary cone configured for use with any of the nozzles disclosed herein of the described disposable cartridge. [Figure 14D] 13 shows a side perspective view of another exemplary cone configured for use with any of the nozzles disclosed herein of the described disposable cartridge. [Figure 15] FIG. 1 is a block diagram of various components and systems that can be included in an electrostatic and / or electrospinning device according to the present disclosure. [Figure 16] FIG. 16 is a block diagram of the user interface of FIG. 15 in accordance with the present disclosure. [Figure 17] FIG. 16 is a block diagram of the controller of FIG. 15 in accordance with the present disclosure. [Figure 18] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system according to the present disclosure. [Figure 19] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system according to the present disclosure. [Figure 20] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system according to the present disclosure. [Figure 21] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system according to the present disclosure. [Figure 22] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Diagram 23] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Figure 24] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Diagram 25] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Figure 26] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Figure 27] 1 is a flow diagram of an exemplary process for operating an electrostatic applicator and disposable cartridge system having an interactive component that provides feedback to a user regarding the status of the device in accordance with the present disclosure. [Figure 28] 13 is a flow diagram of using a proximity sensor to provide feedback to a user regarding optimal applicator and disposable cartridge system positioning in accordance with the present disclosure. [Figure 29]1 is a flow diagram of operating an exemplary applicator and disposable cartridge system according to the present disclosure. [Diagram 30] 1 is a flow diagram of operating an exemplary applicator and disposable cartridge system according to the present disclosure. [Diagram 31] 4 is a flow diagram of operating an exemplary electrostatic applicator system according to the present disclosure. [Diagram 32] 1 is a flow diagram of a computer-implemented method for operating any of the electrostatic applicator systems of the present disclosure. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0090] Although exemplary embodiments of the disclosed technology are described in detail herein, it should be understood that other embodiments are contemplated. Thus, it is not intended that the scope of the disclosed technology be limited to the details of construction and the arrangement of components set forth in the following description or illustrated in the drawings. The disclosed technology is capable of other embodiments and of being practiced or carried out in various ways.

[0091] It should also be noted that as used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. "Comprising" or "containing" or "including" means that at least the specified compounds, elements, particles, or method steps are present in a composition or article or method, but does not exclude the presence of other compounds, materials, particles, or method steps even if those other compounds, materials, particles, or method steps have the same function as the specified one.

[0092] In this disclosure, relative terms such as "about," "substantially," or "approximately" are used to indicate a possible variation of ±10% of the stated value.

[0093] In describing the exemplary embodiments, terms are used for clarity. Each term is intended to contemplate its broadest meaning as understood by those skilled in the art and to include all technical equivalents that operate in a similar manner to achieve a similar purpose. It should also be understood that the reference to one or more steps of a method does not preclude the presence of additional or intervening method steps between those steps explicitly identified. The steps of the method may be performed in a different order than described herein without departing from the scope of the disclosed technology. Similarly, it should also be understood that the reference to one or more components of a device or system does not preclude the presence of additional or intervening components between those components explicitly identified.

[0094] As discussed herein, the treatment site of a "subject" or "patient" may be a wound site or treatment of a human or any animal. It is understood that the animal may be any of a variety of applicable types, including, but not limited to, mammals, veterinary animals, livestock animals, or pet animals. As an example, the animal may be a laboratory animal (e.g., rats, dogs, pigs, monkeys, etc.) that is specifically selected to have certain characteristics similar to humans. It is understood that the subject may be, for example, any applicable human patient.

[0095] As discussed herein, an "operator" may include, but is not limited to, a doctor, surgeon, nurse, physical therapist, or other healthcare professional, or any other suitable individual, or delivery instrument associated with the application of a treatment solution to a treatment site on a subject.

[0096] As discussed herein, the "treatment solution" may be one or more fluids (e.g., liquids and / or emulsion solutions, gels, and / or mixtures) and may include one or more of disinfectant solutions, germicidal solutions, analgesics, exosomes, biologics, chlorhexidine gluconate, povidone-iodine, and / or liquid dressing solutions. Analgesics may include one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime. Biologics may include one or more of stem cells and / or primary mammalian cells, pharmaceuticals, gels (e.g., hydrogels), reconstitutable aspects (e.g., immiscible components and / or lyophilized components that are miscible with one or more solvents). The disinfectant may include one or more alcohols, aldehydes, oxidizing agents, phenols, quaternary ammonium compounds, etc., antimicrobial agents, biguanides, analgesics, surfactants, and / or debridement components, or any other contents and / or agents contemplated for storage within a cartridge of the present disclosure that can be delivered (e.g., applied, squirted, and / or sprayed by an electrostatic applicator) to a treatment site on a patient. The treatment solution may include any concentration or mixture of components disclosed herein.

[0097] The term "treatment solution" can also include one or more traceable materials (e.g., a gel with traceable aspects mixed with the treatment solution). The treatment solution can include any number of small molecule drugs, peptides, cells, and other therapeutic agents. In some embodiments, the treatment solution can include one or more active pharmaceutical ingredients, growth factors, trophic factors, exosomes, mammalian regenerative cells, and / or support matrices. In some embodiments, the treatment solution can include lidocaine, levobupivacaine, acemetacin, ketorolac, etc., or any combination thereof.

[0098] The terms "distal" or "proximal" are used in the following description with reference to a location or direction relative to a reference point (e.g., a user, such as a treating or interventionalist). "Distal" or "distally" is a location away from or in a direction away from a reference point. "Proximal" or "proximally" or "near" is a location near or in a direction toward a reference point.

[0099] Increasing attention and resources are being focused on developing effective treatments for pain and infection control. The most common methods of treating pain and infection include oral and intravenous (IV) administration of drugs. Although these methods are widespread, they often lack the efficacy of the drug delivery methods. For example, when a drug is administered via oral or IV administration, its therapeutic effect is global rather than local, i.e., the drug targets the entire patient rather than the local treatment site. To overcome some of these issues, delivery vehicles such as localized treatments, and more specifically hydrogel compounds, have been developed to provide spatial and temporal control over the release of various therapeutics, including small molecule drugs, peptides, and cells. However, these treatments can also have drawbacks. Synthetic carriers of these therapeutics are often costly, and because they are fragile polymer chains, it can be difficult to sterilize the polymer chains of the solution / hydrogel combination.

[0100] More recently, the concept of electrospraying treatment solutions, including antibacterial and / or analgesic solutions, at the treatment site has been explored. Electrostatic spraying is a technique in which the treatment solution is exposed to an electric field to charge the fluid. The electric field provided by a voltage source can generate an electric charge (e.g., a positive or negative charge) in the fluid being administered. This is particularly useful in the biomedical field, since the natural resting state of human cells is a negative state (i.e., a state of negative charge). This imbalance is created by potassium and sodium ions inside and outside the cells, which form an electrical capacitance within the patient's body. This polarity difference creates a natural attraction between the treatment site and the solution being sprayed.

[0101] However, negative / positive attraction is not the only advantage of electrostatic spraying. For example, by subjecting a fluid to this electric field, small droplets (e.g., micron-sized) can also be generated to provide a relatively uniformly distributed layer of treatment solution. When the electrical stress due to the charge builds up on the droplet beyond its surface tension, the droplet breaks up and / or atomizes into very fine droplets, known as Rayleigh breakup or Coulomb breakup. As discussed herein, the term "atomize" is understood as part or all of the process of converting a substantially liquid solution into very fine particles or droplets. The dielectric constant or conductivity of the solvent can play an important role in determining the morphology of the microparticles. Other factors that affect how a liquid atomizes include vapor pressure, the viscosity and miscibility of the treatment solution, the voltage applied to the solution, etc.

[0102] It is noted that prior designs of electrosprayer devices did not consider these various types of parameters. This is because most prior art electrostatic devices focus on spraying one type of solution, considering common examples such as inkjet sprayers, paint sprayers, etc., which spray a consistent solution at a consistent flow rate and consistent potential. Furthermore, these types of applications did not focus on operational parameters. The present disclosure provides a solution that can maintain sterility for each administration of treatment solution by providing individual pre-filled disposable cartridges that house the components used for electrospraying. Furthermore, each disposable cartridge can be individually adjusted and / or communicate with a reusable electrostatic applicator to individually adjust the parameters required to administer the desired particle (e.g., nanoparticle to microparticle) droplets for the treatment of the target.

[0103] Referring to the drawings, FIG. 1A provides an exemplary base 80 and an exemplary applicator 100 in a disassembled state. In accordance with the present disclosure, the applicator 100 can be used in combination with a disposable cartridge 50. The applicator 100 can include an applicator housing 10 that can include an upper portion 31, a lower base portion 30 at a lower portion, and a handle portion 15 between the portions 30 and 31. Also, a forward cartridge support portion 32 can be disposed between the portions 30 and 32. In some embodiments, an obtuse angle can be formed between the outer surface aspects of the portions 30 and 32, and the handle portion 15 can be perpendicular to the portions 30 and / or 31. Also, although shown as a handheld pistol-shaped device, the reusable applicator 100 need not have a pistol-shaped design, as the components herein can also be combined with other electric sprayer designs, such as, but not limited to, a fully cylindrical handheld electric sprayer design.

[0104] As shown more clearly in FIG. 3, the portion 30 can house a battery B that can provide an electrical potential for generating an electric field in the nozzle assembly 60 of the cartridge 50 and / or power the components of the applicator 100 (e.g., the CPU and / or HV module 86). The battery B can include one or more batteries, including, for example, a direct current battery such as a lithium ion battery. The battery B can provide a voltage sufficient to generate the electrical potentials described above, including but not limited to, from about 1 V to about 40 kV. In some examples, the range can be from about 1 V to 8 kV. In some examples, the voltage supply of the battery B can be one or more rechargeable batteries. In this example, an embodiment of the applicator 100, such as the portion 32, can engage with a charging base 80 that can in turn charge (e.g., inductively) the voltage supply of the battery B when the device is not in use. The portion 30 can be configured to be detached from the charging base 80 by pressing an electrostatic applicator release (not shown). In some examples, the applicator 100 can include an actuator, such as a button 35, that can activate and / or actuate the components of the applicator 100. For example, the button 35 can initiate power supply from battery B (see FIG. 3), which may include a rechargeable modular battery such as a DC battery. By initiating and / or initiating power supply from battery B, the system is powered such that the liquid solution in the cartridge is electrostatically charged via direct charging, inductive charging, indirect charging, or any combination thereof. For direct charging, the liquid solution in the cartridge can flow through an electrostatically charged conductive tube or other conduit such that the liquid solution is charged on contact by direct contact.

[0105] In some examples, battery B may power the high voltage (HV) module 86, air pump 83, circuit board 64, target sensor 45, motor 90, user interface 87, one or more processors (e.g., central processing unit (CPU)) of applicator 100, as well as components of cartridge 50. As described in more detail below, other features may be included in applicator 100 that may obviate the need for button 35, including, for example, an accelerometer, an activation input from a user device, etc.

[0106] The applicator housing 10 can include a cartridge chamber 27 sized and positioned to receive the housing 49 of the disposable cartridge 50, as described in more detail below (see FIGS. 2A, 2B, 3, 4A, 4B). The cartridge chamber 27 can include a distal stepped portion 29 that can connect a connection port of an internal component of the housing 10 to an aspect of the cartridge 50 (e.g., an air supply port). In the example shown in FIGS. 1A, 1B, 1C, the cartridge chamber 27 is located on the top of the gun-type handheld cordless reusable applicator 100, but the cartridge chamber 402 need not be so located. For example, the cartridge chamber 27 can be located on the side of the applicator 100 (e.g., on the side of the housing 10 of the applicator 100, or any other location). In some embodiments, the HV module 86 can include electrical components for providing power to components used to charge and spray the liquid solution of the cartridge 50. For example, the HV module 86 may include components used to supply electricity from voltage wire 92c through port 92a of the cartridge 50 to wire 92d to control the voltage applied to the liquid solution in the cartridge 50, and / or to supply electricity to operate the plunger 71 (or motor 90 for operating the syringe 70, including advancing the plunger 71) to control the flow rate of the liquid solution from the cartridge 50 through the nozzle assembly 60.

[0107] In some embodiments, the HV module 86 can be configured to adjust or control operational aspects of the cartridge 50, including but not limited to frequency, duty cycle, and input voltage, to generate varying output voltages with different efficiencies. In some embodiments, the HV module 86 can be a closed loop system that monitors the output voltage and adjusts input parameters to optimize the output to a desired voltage for use with the cartridge 50. The HV module 86 can also be configured to generate positive and / or negative high voltages using the same board. In some embodiments, the HV module 86 can include a double-sided printed circuit board to minimize the footprint used within the housing 10. In some embodiments, the HV module 86 can include a dedicated module for generating a positive high voltage. In some embodiments, the HV module 86 includes multiple diodes configured to physically rotate (e.g., rotate approximately 180 degrees). In some embodiments, the diodes can be configured to rotate or otherwise adjust their orientation based on the operating instructions of the system. Upon such rotation, in this example, the HV module 86 is configured to reverse the polarity of its diodes in the multiplier stage such that the HV module 86 can generate a positive high voltage and a negative high voltage depending on the orientation of the rotatable diodes. In some embodiments, the HV module 86 can include a first positive high voltage multiplier system and a second negative high voltage multiplier system that is physically separate from the first positive high voltage multiplier system. Each subsystem of the HV module 86 can be located on the same circuit board and can be selectively actuable during operation of the applicator 100 as needed. In some embodiments, each of the subsystems can be located on a separate circuit board.

[0108] The applicator 100 can include one or more processors, e.g., a CPU, that can facilitate activation of the applicator 100, receipt and output of signals related to voltage, flow rate, proximity, etc. of a particular liquid treatment solution.

[0109] Within the housing 10, the applicator 100 can include a piston 94 and a corresponding motor 90 that actuates the syringe 70. The piston 94 can be disposed between the motor 90 and the HV wall 93. The cartridge 50 can be disposed on the opposite side of the HV wall 93 when attached to the chamber 27 of the housing 10. In some embodiments, when the cartridge 50 is positioned as in FIG. 3, a plunger, piston, or other aspect within the barrel of the syringe 70 of the cartridge 50 can be advanced by the piston 94 through the HV wall 93 to advance the contents of the cartridge 50 through the nozzle assembly 60. In some embodiments, the motor 90 can be disposed within the portion 31 adjacent to the user interface 87. In some embodiments, the motor 90 can be a stepper motor, a worm drive motor, a solenoid, or the like. The speed of the motor 90 can be adjusted based on aspects such as the preferred flow rate of the particular liquid solution to be ejected by the nozzle assembly 60 of the cartridge 50.

[0110] As shown in FIG. 3, the housing 10 can include a voltage wire 92c that contacts the voltage contact 92e of the HV module 86 and the cartridge voltage contact 92a of the HV wall 93. When the cartridge 50 is assembled in the chamber 27 of the housing 10, it electrically connects to the voltage contact 92a via the cartridge HV contact 46 (see FIG. 4B, FIG. 5A, FIG. 5B). In operation, the wire 92c provides an electrical connection between the voltage supply of the high voltage module 86, which is powered by the battery B. Within the portion 32 of the housing 20 (e.g., below the chamber 27), the air pump 83 connects with the supply end of the air supply tube 81. When the cartridge 50 is assembled in the chamber 27, the air supply tube 81 in turn supplies air to the air supply tube 76 of the cartridge 50 to provide air for spraying the charged droplets. The air supply of the air pump 83 can provide a high-speed air supply without the need for a separate air hose. In other embodiments, the housing 10 can be connected to an external air hose that provides an air supply for spraying.

[0111] The applicator 100 may include a display screen with its user interface 87, which may include a liquid crystal (LCD) and / or light emitting diode (LED) display. The display screen of the user interface 87 may allow an operator of the applicator 100 to receive information regarding the status of the applicator 100, including the operating parameters of the cartridge 50. For example, the display screen of the user interface 87 may display information regarding what type of liquid solution is in the disposable cartridge 50 connected to the applicator 100. As described above, this information may be written to an internal memory of the disposable cartridge 50, and the CPU of the applicator 100 may receive this information and display this information to the operator of the applicator 100. In some embodiments, the user interface 87 can display a welcome animation, indicate whether the electrostatic applicator is connected to the user device (as described below), indicate whether the applicator 100 is properly grounded, indicate whether a disposable cartridge 50 is installed in the cartridge chamber 27, and indicate what parameters (e.g., flow rate, voltage supply, droplet size, intended target, intended patient condition, recommended proximity, etc.) are being used for a particular liquid solution.

[0112] In some examples, the display screen of the user interface 87 can also have touch screen functionality. For example, the user interface 87 can function as an actuator to activate or control the voltage supply to the voltage wire 92d of the cartridge 50, to activate or control the air flow to the air delivery tube 76, and / or to activate or control the plunger 71 of the syringe 70 to expel fluid from the syringe 70 through the nozzle assembly 60. As described in more detail below, the fluid can be sprayed using actuators 35 (e.g., mechanical triggers, switches, actuators, and / or graphical user interfaces configured to receive input from a user and perform one or more associated actions) and / or other actuation mechanisms, including signals from an external user device.

[0113] With reference to FIG. 4A, a front perspective view of the cartridge 50 is provided, and FIG. 4B shows a rear perspective view of the cartridge 50. Similarly, FIG. 5A shows a rear bottom perspective view of the cartridge 50. FIG. 5B shows a side view of the cartridge with a portion of its outer housing 49 removed, and FIG. 5C shows an exploded perspective view of the internal components of the cartridge 50 with the outer housing 49 removed. FIG. 5B also shows a detailed view of the nozzle housing 60a. It is understood that in some embodiments, the entire housing 60a can be molded as a single integrally formed part and / or molded (e.g., insert molded) from multiple parts or portions. The nozzle housing 60a can include a nozzle outlet channel 62 at a distal end that can be funnel-shaped sized and positioned to accommodate the outlet end of the delivery tube 61. The nozzle housing 60a can include an air inlet port 66 in fluid communication with the nozzle end of the air delivery tube 76 and the inlet port 59 of the cartridge 50.

[0114] The nozzle housing 60a can include a voltage cavity port 69 for connecting a voltage wire 92d and a corresponding voltage tube 92 to the delivery tube 61. One side of the port 69 (e.g., the most distal end of the port 69) can include a contact through which the wire 92d can pass to contact the delivery tube 61. At the other end of the port 69 (e.g., the proximal end of the port 69), the cavity associated with the port 69 can be tubular to secure the outer surface of the voltage tube 92 in a friction fit. The nozzle outlet channel of the housing 60a described above can be located at the distal end of the housing 60a and can receive air from the port 66 and fluid from the delivery tube 61 and eject droplets charged by the voltage wire 92d. In some embodiments, the wire 92d can electrostatically charge the contents in the delivery tube 61 as well as the fluid contents proximate thereto (e.g., the contents in the barrel portion 72 of the syringe 70). 5B and 5C, the voltage wire 92d can include one or more curved surfaces (e.g., at least one downward bend such as connecting through the tube 92, port 69, and contacting the delivery tube 61). The wire 92d can include any number of shapes, including, but not limited to, an S-shape or a serpentine shape. To facilitate the shape of the wire 92d, the tube 92 can include one or more curves or bends, as shown.

[0115] The housing 49 can be formed from a multi-part shell having alignment grooves 55 that can engage with alignment tabs 25 of the cartridge chamber 27. The housing 49 can be formed and / or assembled in a number of ways, including but not limited to machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Suitable materials for the housing 49 can include one or more of glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or plastic materials. In some examples, the housing 49 can include two or more parts of a moldable plastic, e.g., a first half and a second half. The parts of the housing 49 can be assembled with fasteners (e.g., screws, rivets, welds (e.g., sonic welds), one or more straps or snaps, adhesive or adhesive tape, etc.) such that internal components are disposed between the parts and / or respective halves of the housing 49. In some embodiments, the housing 49 can include a housing spray outlet associated with a nozzle assembly 60 that allows the charged treatment solution to be ejected from the cartridge 50.

[0116] The groove 55 can engage with the tab 25 to align the housing to the cartridge chamber 27 with proper alignment between the cartridge 50 and the chamber 27. The housing 49 can include one groove 55 located on either side of the cartridge 50. The groove 55 can include an open proximal end 55p and a closed distal end 55d. When the end 55d of the groove 55 is adjacent to or toward the nozzle assembly 60, the end 55d prevents the tab 25 from sliding deeper into the groove 55. In some embodiments, the proximal end 55p can be opposite the end 55d and can include an open funnel or tapered shape to facilitate alignment and engagement between the groove 55 and the tab 25.

[0117] FIG. 4B specifically illustrates the supply end and contact end of the cartridge 50. The HV contacts 46 may be contact ports recessed in the HV wall 54 and / or disposed on a surface of the cartridge HV wall 54 configured to mount to the HV wall 93 of the housing 10. The HV wall 54 may also include an intake port 47 that may be configured to mate with a corresponding intake port 147 of the HV wall 93 (see, e.g., FIGS. 7A and 7B). As shown in FIGS. 3 and 5A, the cartridge 50 may also include an air supply port 59 configured to receive an air supply tube 81 to place the tubes 81, 76, and the pump 83 in fluid communication with one another. The air supply port 59 may be disposed in a stepped portion of the housing 49 that is shaped to correspondingly mount to the stepped portion 29 of the housing 49. The supply port 59 of the air supply tube 81 may extend at least partially from the housing 49 and be shaped to be inserted into the air supply port 29a of the applicator housing 10 at or adjacent to the stepped portion 29. In some embodiments, the air delivery tube 76 of the cartridge 50 and the air delivery tube 81 of the housing 10 can include a combination of both flexible and rigid materials (e.g., nylon braid). In some embodiments, the air delivery tube 76 of the cartridge 50 and the air delivery tube 81 of the housing 10 can be manufactured from a soft, fluid-tight material, such as elastomer, rubber, silicone, polyvinyl chloride, etc. In some embodiments, the air delivery tube 76 of the cartridge 50 and the air delivery tube 81 of the housing 10 can also be insert molded and / or overmolded with a combination of a softer, more flexible, fluid-tight material and / or one or more rigid materials (e.g., metals, alloys, etc.).

[0118] Once firmly engaged with the chamber 27, the cartridge 50 can be released by a release button 57. As shown in FIGS. 5A, 5B, and 6, the button 57 can at least partially penetrate the underside 53 of the housing 49 through an opening in the underside 53 of the housing 49. The button 57 can be, for example, a latch that is connected to a portion of the syringe 70 and can be removed from the cartridge 50 when the cartridge 50 is ready to be attached to the housing 10. This can indicate to a user that the cartridge 50 has not yet been used and the contents therein (e.g., liquid treatment solution) have not been used. In some examples, the contents stored within the syringe 70 can be sterilized and the release button 57 can indicate that the contents of the disposable cartridge 50 are sterile and have not been used (e.g., have not yet been used on a previous patient). In some embodiments, the button 57 can prevent the syringe 70 and any components thereof from advancing the contents therein prior to use. In some embodiments, the button 57 may include a near field communication (NFC) tag from which cartridge identification information and other operating parameters can be read that indicates to a user that the cartridge 50 has not yet been used and that the contents therein (e.g., liquid treatment solution) have not been used.

[0119] As also shown in FIGS. 5A, 5B, and 6, the cartridge 50 can house and / or at least partially enclose within its housing 49 the air delivery tube 76, voltage tube 92, and syringe 70 described above. The syringe 70 can be an assembly including a glass or plastic syringe for storing a liquid solution to be applied using the disposable cartridge 50. The syringe 70 can be pre-filled with a desired liquid solution and then assembled within the disposable cartridge 50. At a proximal end, the syringe 70 can include a movable plunger 71, a movable stopper 71a, and a barrel portion 72 extending distally therefrom. The plunger 71 and stopper 71a are configured to advance within the barrel 72 to advance the contents of the barrel portion 72 through a luer lock 74 disposed at a distal end of the portion 72. An inner distal delivery tube 61 can extend distally from the luer lock 74 through the nozzle assembly 60. The delivery tube 61 can be generally tubular with a blunt distal tip. However, the delivery tube 61 is not so limited and may include a piercing tip. The delivery tube 61 may preferably range from about 15 gauge (0.072 inch outer diameter, 0.054 inch inner diameter) to about 30 gauge (0.01225 inch outer diameter and 0.00625 inch inner diameter). At the distal end of the luer lock 74, the distal end of the voltage wire 92d may extend through the nozzle tube 92 and connect to a proximal portion of the inner distal delivery tube 61, which may be constructed from one or more conductive materials. The wire 92d may include a needle-like structure made of one or more conductive materials (e.g., metals) that may generate an electric field for charging the liquid solution flowing from the syringe 70 through the nozzle assembly 60. In operation, the syringe 70 may be configured to deliver the stored liquid solution from the barrel portion 72 through the delivery tube 61 at a predetermined rate and ultimately sprayed via the nozzle assembly 60 to a treatment site (e.g., a wound site on a patient).

[0120] In some embodiments, the voltage wire 92d can be in electrical communication with a voltage source at one end (e.g., port 46) and with a nozzle tube (e.g., nozzle tube 92d) at the nozzle end, as shown in FIGS. 5B, 5C. Although not shown, it is contemplated that in some embodiments, the contact 46 can be in direct electrical communication with an embodiment of the syringe 70 (e.g., directly connected to the plunger 71) rather than passing the wire 92d from the port 46 to the tube 61. The voltage wire 92d can be aligned substantially axially along the syringe 70 within the disposable cartridge 50. The nozzle tube 92 can be positioned such that the nozzle end of the wire 92d can electrically charge the contents of the syringe 70 (e.g., by contacting the delivery tube 61 upon distal withdrawal of the luer lock 74) prior to delivery from the nozzle assembly 60. For example, the distal end of the luer lock 74 through which the delivery tube 61 passes can be electrically connected to the distal end of the wire 92d, as shown in FIG. 5B, and the opposite end (contact end 46) of the voltage wire 92d can be in electrical communication with the contact end 92a, wire 92c, and port 92e of the HV module 86. In some embodiments, the wire loop or hook of the wire 92d can contact the delivery tube 61. In some embodiments, the wire loop or hook of the wire 92d can include one or more conductive materials, such as copper, steel, or any other metal alloy. In some embodiments, the inner diameter of the wire loop or hook of the wire 92d can be configured to allow contact with the delivery tube 61. In some embodiments, the voltage wire 92d can be attached in place (e.g., spot welded, crimped, etc.) and then potted with a high dielectric adhesive. The wire loop or hook of the wire 92d can at least partially surround the outer surface of the delivery tube 61 and provide an electric potential thereto.

[0121] In some examples, the NFC tag of the disposable cartridge 50 and / or other internal memory of the cartridge 50 may contain other information regarding the contents stored therein (e.g., liquid treatment solution, recommended operating parameters, tracking information, expiration date, etc.). This information may be used, for example, by the applicator 100 to monitor the type of contents, its volume, as well as to modify the voltage, flow rate, recommended travel distance (i.e., proximity), etc. for a particular solution. In some examples, this information may be stored in an internal memory that may include, but is not limited to, RAM, ROM, EPROM, EEPROM, etc. Information on the internal memory 120 may be relayed to the applicator 100 via the internal memory and / or NFC tag, and this information may be used to adjust or otherwise control aspects of the cartridge (e.g., components of the syringe 70 such as stopper 71a, flow rate, air intake from pump 83, voltage applied to delivery tube 61 by wire 92d, etc.). In some embodiments, one or more processors of applicator 100 can be configured to read information on an NFC tag or other internal memory of cartridge 50 related to operational parameters of cartridge 50 and display the read NFC information (e.g., identification information, volumetric information, etc. of the contents of cartridge 50) on a display screen. In some embodiments, operational information can be written to the NFC by a processor of the electrostatic applicator system.

[0122] The distal end of the tube 92 can be configured to physically connect with the port 69 of the nozzle assembly 60. Similarly, the air delivery tube 76 can extend from the cartridge air port 59 to the nozzle air port 66 of the nozzle assembly 60. The tube 76 can provide high velocity air for spraying the contents of the cartridge 50 (e.g., contents contained within the syringe 70) at the treatment site. The distal end of the tube 76 via the port 66 can be an outlet for the air delivery tube 76 to provide a high velocity air stream to the nozzle assembly 60.

[0123] In some embodiments, one or more accumulators (not shown) may be disposable within the disposable cartridge 50 or housing, such that the one or more accumulators are configured to receive, store, and release energy during operation of the disposable cartridge 50. Examples of one or more accumulators contemplated for use with the disposable cartridge 50 may include one or more springs, a flywheel energy storage mechanism, a battery, a capacitor, or the like.

[0124] With reference to FIG. 6, a spring 106 (e.g., a deployable latching spring) can be in communication with the cartridge side of the button 57. In operation, the spring 106 can provide a spring bias to the button 57 that keeps the button 57 in a closed position, as shown in the enlarged cross-sectional view of portion 6 of FIG. 3 shown in FIG. 6. In some embodiments, the button 57 deployed with the spring 106 in FIG. 6 can be a living hinge configured to maintain the button 57 in the closed, retained position shown. A solenoid 115 can be provided on the housing side of the housing 10. In FIG. 6, the solenoid 115 is shown in a de-energized position. A solenoid plunger 117 is provided within the solenoid 115 and can include a return spring. A solenoid plunger tip 113 can be provided on the distal end of the plunger 117. As can also be seen, a rigid housing catch 109 is provided to hold the button 57 in a closed configuration by the solenoid 115, including the plunger 117 and tip 113. The illustrated example of FIG. 6 is just one method for providing easy and secure attachment and detachment of the cartridge 50 to the housing 10 of the applicator 100, and other attachment techniques are contemplated for use with the disposable cartridge 50 of the present disclosure.

[0125] FIG. 7A shows an exemplary side cross-sectional close-up view of the HV wall 93 when the cartridge 50 is not connected to the housing 10, and FIG. 7B shows an exemplary embodiment of the HV wall 93 when the cartridge 50 is connected to the housing 10. In FIG. 7A, the embodiment of the HV wall 93 for air intake and air exhaust is closed to the housing 10. Specifically, the port 147 can include an air passage that passes through the HV wall 93 and ultimately opens to the port 47 of the cartridge 50. The associated plumbing of the port 147 is not shown, but in use, plumbing is provided between the port 147 and the pump 83. The port 147 can include a solid valve seal housing in which the intake port 93a of the HV wall 93 can nest. In some embodiments, the valve seal cone spring can be positioned to restrain the corresponding valve seal 143 in a sealed closed position, as shown in FIG. 7A. In FIG. 7B, the cartridge 50 is shown coupled to the HV wall 93. Specifically, port 47 of cartridge 50 is shown inserted into port 93a, thereby biasing seal 143 into an open configuration. Air can now pass through seal 143 and enter cartridge 50.

[0126] FIG. 8A illustrates a side cross-sectional view of an exemplary embodiment of the actuator 35 illustrated in the previous FIGS. 1A, 1B, 1C, 2A, 2B, and 3. Specifically, the actuator 35 can include a switch base 35a configured to directly couple to an embodiment of the housing 10. In some embodiments, the base 35a can be coupled to a flexible boot 35f, which can be directly coupled to a switch cap 35c. One or more switch contacts 35b can be disposed within the base 35a and communicate with a switch return spring 35d and a switch shorting contact 35e. In some embodiments, the actuator 35 can be configured to withstand high pressure water and hard water splashes (e.g., IP6X waterproof and dustproof rating). In some embodiments, the flexible boot 35f is configured to surround the components of the actuator 35 and allow movement while maintaining a seal.

[0127] 8B shows a side cross-sectional view of another exemplary actuator 35' that may be used in the previous examples of FIGS. 1A, 1B, 1C, 2A, 2B, and 3. The previous flexible boot 35f is replaced with a flexible internal bellows boot 35' that is disposed inside the switch cap 35c and directly bonded to the base 35a. In some embodiments, the flexible internal bellows boot 35' is configured to surround the return spring 35d and contacts 35e to withstand high pressure water and hard splashes (e.g., IP6X waterproof and dustproof rating).

[0128] Referring to FIG. 9A, a front perspective view of a cartridge 250 configured for electrospinning is provided, and FIG. 9B shows a rear perspective view of the cartridge 250. The cartridge 250 embodiment includes similar structural elements and numerals indicating features similar to those in the cartridge 50. In some embodiments, the nozzle 260 of the cartridge 250 is configured to receive source liquid from a syringe 270 for fibers and to supply highly compressed air through one or more injection holes 267 such that the source liquid in the syringe 270 can be injected with air and a voltage applied thereto to generate and expel electrospun fibers having fine diameters. In some embodiments, the holes 267 can be radially arranged and formed around the tube 261. FIG. 9B specifically illustrates the supply end and contact end of the cartridge 250. The HV contacts 246 are disposed on a surface of the cartridge HV wall 254 configured to be attached to the HV wall 93 of the housing 10. The HV wall 254 may also include an intake port 247 that may be configured to couple to a corresponding intake port 147 in the HV wall 93 (see, for example, FIGS. 7A and 7B).

[0129] Similarly, FIG. 10A shows a rear bottom perspective view of cartridge 250. FIG. 10B shows a side view of the cartridge with a portion of its outer housing 249 removed, and FIG. 10C shows an exploded perspective view of the internal components of cartridge 250 with outer housing 249 removed. Like housing 49, housing 249 can be formed and / or assembled in a number of ways, including but not limited to machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Suitable materials for housing 249 can include one or more of glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or a plastic material.

[0130] As shown in Figures 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 arranged around the channel 262. As shown in Figure 9A, the housing 260a can include six holes arranged radially around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 can be replaced with an outer concentric outlet channel that completely surrounds the channel 262 and is also in fluid communication with the port 266. In use, air pumped from the port 266 and exiting through the holes 267 can form an air curtain around the electrospun fibers being released from the tube 261. 9A, the holes 267 are generally straight in shape, or angled in a parallel and / or axially aligned fashion relative to the tube 261, such that the corresponding air curtain shapes are similarly parallel and / or axially aligned. In other examples, the holes 267 are angled upward relative to the longitudinal axis of the tube 261, such that the air curtain shapes taper outwardly in a funnel shape. In other examples, the holes 267 are angled downward relative to the longitudinal axis of the tube 261, such that the air curtain shapes taper inwardly converging.

[0131] In some examples, the housing 249 can include two or more parts of moldable plastic, such as a first half and a second half (when assembled together, referred to herein as the housing 249). The two or more parts can be assembled with fasteners (e.g., screws, rivets, welds (e.g., sonic welds), one or more straps or snaps, adhesive or adhesive tape, etc.) such that internal components are disposed between the parts and / or respective halves of the housing 249. In some embodiments, the housing 249 can include a fiber outlet associated with the nozzle assembly 260 that allows the atomized and charged treatment solution to be ejected from the cartridge 250. The port 247 is configured to receive the air delivery tube 81 to fluidly connect the tubes 81, 76 and the pump 83 to one another.

[0132] Similar to cartridge 50, cartridge 250 can be securely engaged with chamber 27. Although not shown, cartridge 250 can house an air delivery tube, a voltage tube, and a syringe 270 within its housing 249. Similar to syringe 270, syringe 270 can be an assembly including a glass or plastic syringe for storing a liquid solution to be applied using disposable cartridge 250. Syringe 270 can be pre-filled with a desired liquid solution before being assembled into disposable cartridge 250. At a proximal end, syringe 270 can include a plunger and a barrel portion 272 extending distally therefrom. The contents of syringe 270 can be advanced through a luer lock 274 disposed at the distal end of portion 272. An inner distal delivery tube 261 can extend distally from luer lock 274 through nozzle assembly 260. At the distal end of the luer lock 274, a distal end of a voltage wire (not shown, but similar to wire 92d of cartridge 50) can extend through a nozzle tube of the cartridge 250 and connect to a proximal portion of an inner distal delivery tube 261, which can be constructed from one or more conductive materials. In operation, the syringe 270 can be configured to deliver electrospun fibers from a stored liquid solution at a predetermined rate from the barrel portion 272 through the delivery tube 261 and ultimately expel them via the nozzle assembly 260 to a treatment site (e.g., a wound site of a patient).

[0133] In some examples, the NFC tag of the disposable cartridge 250 described above and / or other internal memory of the cartridge 250 may contain other information regarding the contents (e.g., liquid treatment solution) stored therein. This information may be used, for example, by the applicator 100 to monitor the type of contents, its volume, as well as to modify the voltage, flow rate, recommended travel distance (i.e., proximity), etc. for a particular solution. In some examples, this information may be stored in an internal memory, which may include, but is not limited to, RAM, ROM, EPROM, EEPROM, etc. Information on the internal memory 120 may be relayed to the applicator 100 via the internal memory and / or NFC tag, and this information may be used to adjust or otherwise control aspects of the cartridge (e.g., components of the syringe 270).

[0134] FIG. 11A shows a perspective view of the internal components of another exemplary electrostatic cartridge 350 contemplated for use in the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, and 3, including a pair of syringes and an electrostatic nozzle. FIG. 11B shows a side cross-sectional view of the exemplary internal components shown in FIG. 11A. Strictly for illustrative purposes to view these internal components, the outer housing of the cartridge 350 is not shown in FIGS. 11A and 11B. In contrast to the cartridges 50 and 250 described above, the cartridge 350 can include within its housing a multi-plunger syringe 370, such that each sub-syringe of the multi-plunger syringe 370 can include its own air supply tube, voltage tube 392, barrel portion 372, stopper 371a, and syringe actuation shaft 371. The actuation shafts 371 of the multi-plunger syringe 370 may be connected proximally via a central drive surface 371b such that the advancement surface 371b simultaneously advances the respective stoppers 371a on each connected actuation shaft 371 to urge the contents stored in the respective portions 372 distally through the respective luer locks 374 and ultimately to the respective nozzle assemblies 360. In some embodiments, the voltage tubes 392 and respective voltage wires (not shown) of the example shown in FIGS. 11A and 11B may include separate independent high voltage inputs. In some embodiments, the example of FIGS. 11A and 11B is configured to increase the output of deliverable treatment solution therefrom (e.g., electrosprayed contents, electrospun fibers, etc.) and to cover a larger area more quickly via multiple nozzle assemblies with separate and independent high voltages throughout the fluid path as shown. In some embodiments, the syringe 370 may be configured such that the subassemblies dispense at different ratios other than 1:1. Although only two subassemblies are shown in Figures 11A and 11B, it is contemplated that more than two subassemblies may be used, if desired.

[0135] FIG. 12A shows a perspective view of the internal components of another exemplary electrostatic cartridge 450 contemplated for use in the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, 3, including a pair of syringes and an electrostatic nozzle. FIG. 12B shows a side cross-sectional view of the exemplary internal components shown in FIG. 12A. Strictly for illustrative purposes to view these internal components, the outer housing of the cartridge 450 is not shown in FIGS. 12A and 12B. In some embodiments, the examples of FIGS. 12A and 12B are configured to increase the yield of deliverable treatment solution therefrom (e.g., electrosprayed contents, electrospun fibers, etc.) and to cover a larger area more quickly via multiple nozzle assemblies with separate and independent high voltages throughout the fluid path, as shown. In some embodiments, the first subassembly of the syringe 470 can include a rod 471, a stopper 471a, a barrel portion 472, a luer lock 474, and a nozzle assembly 460, which are collectively configured for electrospraying. In some embodiments, the second subassembly of the syringe 470 can include a rod 471', a stopper 471a', a barrel portion 472', a luer lock 474', and an electrospinning tube 461', which are collectively configured for electrospraying. In some embodiments, the syringe 470 can be configured such that the subassemblies dispense in different ratios other than 1:1. In some embodiments, the use of each of the first and second subassemblies of the syringe 470 is advantageous to utilize both electrospraying and electrospinning in a single cartridge. In some embodiments, the barrel portions 472 and 472' can be configured to accommodate different volumes and / or types of fluid solutions.

[0136] In contrast to the cartridges 50 and 250 described above, the cartridge 450 may include within its housing a multiple plunger syringe 470, whereby each sub-syringe of the multiple plunger syringe 470 may include its own air delivery tube, voltage tube 492, barrel portion 472, 472', stopper 471a, 471a', and syringe rod 471, 471'. The shafts 471, 471' of the multiple plunger syringe 470 may be proximally connected via a central drive surface 471b such that the advancement surface 471b simultaneously advances the respective stoppers 471a, 471a' to each connected rod 471, 471' to urge the contents stored in the respective portions 472, 472' distally via the respective luer locks 474, 474' and ultimately to the respective nozzle assemblies. In some embodiments, the example voltage tubes 492 and respective voltage wires (not shown) shown in Figures 12A and 12B can include separate and independent high voltage inputs. Although only two subassemblies are shown in Figures 12A and 12B, it is contemplated that more than two subassemblies can be used, if desired.

[0137] FIG. 13A shows a perspective view of the internal components of another exemplary electrostatic cartridge 550 contemplated for use in the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, and 3, including a pair of syringes and an electrostatic nozzle. FIG. 13B shows a side cross-sectional view of the exemplary internal components shown in FIG. 13A. Strictly for illustrative purposes to view these internal components, the outer housing of the cartridge 550 is not shown in FIGS. 13A and 13B. In contrast to the cartridges 50 and 250 described above, the cartridge 550 can include a multi-plunger syringe 570 within its housing, such that each sub-syringe of the multi-plunger syringe 570 can include its own air supply tube, voltage tube 592, barrel portion 572, stopper 571a, and syringe rod 571. The actuation shaft 571 of the multi-plunger syringe 570 may be connected proximally via a central drive surface 571b such that the advancement surfaces 571b simultaneously advance the respective stoppers 571a on each connected rod 571 to urge the contents stored in the respective portions 572 distally through the respective luer locks 574 and ultimately to the respective nozzle assemblies 560.

[0138] In the example of FIGS. 13A and 13B, each of the barrel portions 572 and corresponding subassembly structures can be interconnected by a Y-shaped delivery needle 561. As shown, the tube 561 includes a proximal port in fluid communication with each luer lock 574 and barrel portion 572, and is coupled at a single distal end through which the solution can be expelled or ejected. A voltage tube 592 and corresponding voltage wire (not shown) can be coupled to the delivery tube 561 proximal to the distal-most end of the tube 561 such that all solution expelled from the delivery tube 561 is charged by the voltage wire. Although a Y-shaped member is shown, any number of syringe subassemblies can be used in the cartridge 550, as desired. In some embodiments, the voltage tube 592 and respective voltage wire (not shown) of the example shown in FIGS. 13A and 13B can include separate and independent high voltage inputs. In some embodiments, the examples of Figures 13A and 13B are configured to increase the yield of deliverable treatment solution therefrom (e.g., electrosprayed contents, electrospun fibers, etc.) and to cover a larger area more quickly via multiple nozzle assemblies with separate and independent high voltages throughout the fluid path, as shown. In some embodiments, the syringe 570 can be configured such that the subassemblies dispense in different ratios other than 1:1. Although only two subassemblies are shown in Figures 13A and 13B, it is contemplated that more than two subassemblies can be used, if desired.

[0139] FIG. 14A shows a side perspective view of an exemplary cone 607, 603 configured for use with any of the nozzle assemblies disclosed herein of the described disposable cartridge. In some embodiments, the cone 603 may be a physical cone of any material attached to the distal end of the nozzle assembly or directly attached to the housing 10. In some embodiments, the cone 607 may be attached directly to the distal end of a delivery tube associated with the respective nozzle assembly. In some embodiments, the cone 603 may be configured to protect the release of electrosprayed or electrospun material from the respective system (e.g., the applicator 100 and any disposable cartridge connected thereto) to the treatment site (e.g., a wound site on a patient) by preventing interference from external airflow and / or external forces. In some embodiments, the cone 603 may be configured to control airflow within the respective nozzle assembly by reflecting the spray off its cone walls. In some embodiments, when attached to the housing 10 and / or respective nozzle assembly, the cone 603 can be configured such that one or more lights (e.g., LED lights) can surround the proximal end of the cone from the electrostatic applicator and generate a light pattern (e.g., a light ring) via a light pipe effect to the target site to aid in aiming. In some embodiments, if a translucent material is used for the cone 603, the cone can disperse light from the applicator 100, including different colors, to inform the user of the appropriate distance with a warning if the applicator is too close or too far.

[0140] 14B shows a side perspective view of another exemplary cone 703 configured for use with any of the nozzle assemblies disclosed herein of the described disposable cartridge. In some embodiments, the cone 703 may be a physical cone of any material that is attached to the distal end of the nozzle assembly or directly to the housing 10. Similarly, the cone 703 may be illuminated when solution is being expelled therefrom. For example, the inner surface 709 of the cone 703 may be configured to illuminate or may be plated or finished to a non-stick surface.

[0141] 14C shows a side perspective view of another exemplary cone 803 configured for use with any of the nozzle assemblies disclosed herein of the described disposable cartridge. In some embodiments, the cone 803 may be a physical cone of any material that is attached to the distal end of the nozzle assembly or directly to the housing 10. In some embodiments, the inner surface 809 of the cone 803 may be plated or finished with a conductive surface that may have the same polarity as the fluid being dispensed, which aids in the dispense direction. The distal edge 808 of the cone 803 may be left without that same conductive surface plating and / or finish.

[0142] 14D shows a side perspective view of another exemplary cone 903 configured for use with any of the nozzle assemblies disclosed herein of the described disposable cartridge. In some embodiments, the cone 903 may be a physical cone of any material that is attached to the distal end of the nozzle assembly or directly to the housing 10. In some embodiments, the inner surface 909 of the cone 903 may be plated or finished with a plurality of conductive surfaces (e.g., radially separated surfaces that can be charged to repel and / or attract solution and alter dispensing direction).

[0143] 15, 16, and 17 are block diagrams of various components and systems that may be included in an electrostatic applicator system (e.g., in applicator 100 and / or any of disposable cartridges 50, 250, 350, 450, 550) according to the present disclosure. A controller 1500, which may include a CPU, may communicate with various components and systems to operate the electrostatic applicator. For example, controller 1500 may communicate with a disposable cartridge to receive information regarding the particular fluid contained within the cartridge. This information communicated to controller 1500 (e.g., via on-board memory) may include information regarding preferred fluid flow rates (e.g., by adjusting motor speed), air supply rates, voltages (e.g., by adjusting the potential between a voltage supply (e.g., HV module 86) and a delivery tube of each nozzle assembly of each cartridge), and the like, so that preferred nanoparticles may be formed from the therapeutic solution to be atomized. This information allows a single reusable applicator 100 to be used with many different disposable cartridges 50, 250, 350, 450, 550 having different solutions. Furthermore, not only are the fluids within each disposable cartridge 50, 250, 350, 450, 550 potentially different. For example, different disposable cartridges 50, 250, 350, 450, 550 may have different air delivery tubes, voltage wires, and / or nozzle assemblies depending on the particular use of the disposable cartridge 50, 250, 350, 450, 550. To this end, this component information may also be relayed to the controller 1500 so that the reusable applicator 100 may be adjusted accordingly.

[0144] The controller 1500 can communicate with a sensor subsystem 1502 that includes various sensors that can be used to operate the reusable applicator 100. The sensor subsystem 1502 can include an accelerometer 1504 that can be used to wake up the CPU when the user moves the reusable applicator 100. For example, the reusable applicator 100 can automatically turn on (e.g., the CPU can receive power) when the accelerometer detects movement of the reusable electrostatic applicator in addition to or in lieu of any button or capacitive input from the associated user interface described above. The sensor subsystem 1502 can include a cleavage detector 1506 located proximate the cartridge chamber 27 to determine if the cartridge is sufficiently attached to the chamber 27. The cleavage detector 1506 can function as a safety measure to ensure that the disposable cartridge 50, 250, 350, 450, 550 is fully seated in the chamber 27 before the applicator 100 can be activated. The cleavage detector 1506 can be a pressure sensor, a switch, or the like.

[0145] The sensor subsystem 1502 may include a proximity sensor 1508 for detecting how close the reusable applicator 100 is to a treatment or target site. The proximity sensor 1508 may be located at the distal end of the reusable applicator 100, for example, proximate or adjacent to the spray outlet of the respective cartridge 50, 250, 350, 450, 550. Alternatively, the proximity sensor 1508 may be located on the disposable cartridge 50, 250, 350, 450, 550, for example, proximate or adjacent to the housing spray outlet of the respective cartridge 50, 250, 350, 450, 550. The proximity sensor 1508 may include, but is not limited to, an inductive proximity sensor, a capacitive proximity sensor, a photoelectric proximity sensor, and the like. The proximity sensor 1508 may be a safety feature (e.g., configured to detect the proximity between the electrostatic applicator and the target) used to indicate to an operator if the electrostatic applicator is within a preferred distance to the target object. For example, the distance traveled by the charged droplets may affect the morphology of the droplets when they contact the target site. To this end, the proximity sensor 1508 may send a signal to the controller 1500 indicative of the distance to the target object, and the controller 1500 may output a signal to the user interface 1536 (e.g., a display screen, an external user device, etc.) to alert the user if the device is too far or too close to the target site. This information may be based on information stored in the on-board memory of the disposable cartridge 50, 250, 350, 450, 550, as described above.

[0146] The sensor subsystem 1502 can include a gyrometer 1510 (or gyroscope) that can be used to help measure or maintain a particular positioning of the reusable applicator 100. For example, the gyrometer 1510 can output a signal to a user interface 1536 (e.g., a display screen, an external user device, etc.) to indicate to a user that the device should be moved to an upright configuration or any other configuration. The sensor subsystem 1502 can also include the handle ground portion 1426 described above. In addition to grounding the operator, the handle ground portion 1426 can be used to detect whether the user is gripping the device and whether the device should be activated.

[0147] The controller 1500 can communicate with a control subsystem 1514 that includes various sensors, switches, etc. that can be used to operate the reusable applicator 100 as desired. The control subsystem 1514 can include a cartridge temperature sensor 1516. Although it is contemplated that the disposable cartridges 50, 250, 350, 450, 550 can be stored and used at room temperature, the cartridges can also be stored in other conditions, such as in a frozen state to preserve the therapeutic solution stored therein. The cartridge temperature sensor 1516 can detect the temperature of the therapeutic solution and alert the user if the solution is too cold or too hot to be administered to the patient's skin.

[0148] The control subsystem 1514 can include a pressure sensor 1518 positioned to read the air pressure of the air flow entering each cartridge through an air supply (e.g., an air supply associated with pump 83). This pressure information can be used by the controller 1500 to determine whether the air flow through the device is providing a preferred air velocity for the particular fluid being sprayed. The control subsystem 1514 can include a flow meter 1520 positioned to read the fluid flow rate of the fluid through or out of the nozzle of each cartridge 50, 250, 350, 450, 550. This flow rate information can be used by the controller 1500 to determine whether the fluid flow rate through the device is providing a volume for the particular solution being sprayed.

[0149] The control subsystem 1514 can include a motor limit switch 1522. The motor limit switch 1522 can be used to define the speed at which the piston of the applicator is actuated to further define and / or adjust the flow rate of the treatment solution. The control subsystem 1514 can include a voltmeter 524. The voltmeter 524 can be used to measure the voltage being applied to the nozzle tube 106. If the voltage is off for a particular fluid for any reason, a warning can be sent to the user interface 1536 (e.g., a display screen of the user interface 87, an external user device, etc.).

[0150] In some embodiments, the control subsystem 1514 can include or communicate with a cartridge detection switch configured to detect the presence of a cartridge when assembled with the electrostatic applicator. If a presence is detected, one or more operations associated with the respective cartridge can be executed or initiated. In some embodiments, the control subsystem 1514 can include or communicate with an NFC chip of the disposable cartridge, whereby the NFC chip can include an on-board memory having information regarding the characteristics of the contents stored in the syringe of the cartridge and / or in the cartridge (e.g., treatment solution), including operational parameters of the contents of the cartridge, such as whether the cartridge is sealed or unsealed, flow rate, electrical potential, and / or nozzle settings associated with the nozzle, to adjust motor speed or applied voltage from the cartridge and / or electrostatic applicator to the contents to be deposited at the treatment site.

[0151] The controller 1500 can also receive a signal indicating whether the ground strap 424 is attached to an external ground (e.g., the patient's wound site and / or target). If not attached to an external ground, the controller 1500 can send a warning to the user interface 1536 and / or inhibit activation of the reusable applicator 100 (e.g., prevent electrical connection between the voltage supply of the HV module 86 and each nozzle of the respective cartridge 50, 250, 350, 450, 550, e.g., via a switch). The controller 1500 can also communicate with a charger system 1530. As described above, the voltage supply 420 can include one or more rechargeable batteries. The charger system 1530 can include AC / DC converter(s) and inductive integrated circuit(s) to manage charging of the rechargeable voltage supply of the HV module 86.

[0152] The controller 1500 can also communicate with a communication subsystem 1532. The communication subsystem 1532 can be embedded within the CPU and / or HV module 86 and can include one or more transceivers capable of communicating with external devices. The one or more transceivers can be compatible with short-range wireless communication connections, such as, but not limited to, radio frequency identification (RFID), near field communication (NFC), Bluetooth™, low energy Bluetooth™ (BLE), WiFi™, ZigBee™, and / or similar connections. The communication subsystem 1532 can enable the reusable applicator 100 to communicate with external devices, such as a user device. The user device can include a mobile cellular device, a personal digital assistant (PDA), a tablet, a laptop or desktop computer, a smart wearable device, and the like. In this example, the user device can operate similarly to a display screen to provide information to the device operator. For example, a display screen of the user device can be used in addition to or instead of a display screen. Wireless communication between the reusable applicator 100 and a user device can provide the option of using the user device as an actuator to activate a spray sequence of the electrostatic applicator. For example, activation input to the controller 1500 (or CPU) can include providing an input to a display screen of the external user device.

[0153] Additionally, information regarding the fluid in the disposable cartridge 50, 250, 350, 450, 550 can be entered into the user device to inform the controller 1500 which spray parameters should be used for a particular cartridge. In some examples, a bar code, quick response (QR) code, or the like can be placed on the disposable cartridge 50, 250, 350, 450, 550. The user can scan the code with a camera or other scanner on the user device, and the information can be relayed to the controller 1500. The controller 1500 can then determine the spray parameters required for the particular cartridge. The user can then enter an activation input (e.g., pressing an icon on the screen of the user device) to begin spraying of the treatment solution.

[0154] Referring again to FIG. 15, the controller 1500 can communicate with a user interface 1536 that can provide information to and receive information from an operator of the reusable applicator 100. FIG. 16 provides a detailed block diagram of an exemplary user interface 1536. The user interface 1536 can include a display screen of the user interface 87 described above. For example, the user interface 1536 can include an LCD / LED screen 1538 for providing information to the user regarding the status of the device. In some examples, the user interface 1536 can include a display touch panel 1540. In examples where the user interface 1536 (e.g., the previous user interface 87) is a display screen on the reusable applicator 100, the display screen can include touch screen functionality. This can enable the display screen to receive an activation input for initiating a spray sequence of the reusable applicator 100. For example, the display screen can provide an icon that can function as a virtual "actuator" for initiating a spray sequence. Additionally, information regarding the fluids contained in a particular disposable cartridge 50, 250, 350, 450, 550 can be entered into this display touch panel 1540 to inform the controller 1500 (or CPU) which parameters should be used for a particular processing solution.

[0155] The user interface 1536 may include a buzzer 1542. The buzzer 1542 may include one or more speakers that may indicate to the operator if a problem should be addressed with the device. For example, the buzzer 1542 may provide audible feedback regarding a particular condition if the disposable cartridge 50, 250, 350, 450, 550 is not fully seated, if the ground of the applicator 100 (e.g., the ground strap 1424 or the handle ground 1426) does not detect a proper ground, if the voltage supply of the HV module 86 is low power or should be charged, etc. Additionally, the display screen of the user interface 87 may provide visual feedback to further alert the user of a particular problem. Additionally or alternatively, the user interface 1536 may include a vibration motor 1544 that may indicate to the user via haptic feedback when a problem occurs. The user interface 1536 may include a start / stop button 1546. Alternatively, the start / stop button 1546 can be integrated into a display screen, such as the display screen of the user interface 87 or a display screen on an external user device, such that activation of the device can be performed within a screen having touch screen functionality. The user interface 1536 can include an actuator 1555 (e.g., a trigger). As described above, the actuator 1555 can be an actuator, a virtual actuator in the user interface of an external user device, or a virtual actuator as an icon within the display screen of the user interface 87.

[0156] FIG. 17 is a block diagram of an exemplary controller 1500 according to the present disclosure. As described above, the controller 1500 can include one or more processors, such as, for example, a CPU. The CPU can include one or more of a microprocessor, a microcontroller, a digital signal processor, a coprocessor, and / or a combination thereof that can execute stored instructions and operate on data. The CPU can comprise a single core or a multi-core processor that simultaneously performs parallel processing. For example, the CPU can be a single core processor configured with virtual processing technology. The CPU can simultaneously execute and control multiple processes using logical processors.

[0157] The controller 1500 can include a memory 1560. The memory 1560 can be in communication with one or more processors (e.g., CPUs). The memory 1560 can include instructions, such as programs 1580 or other applications, that cause the CPU and / or controller 1500 to complete any of the processes described herein. For example, the memory 1560 can include instructions that cause the controller 1500 and / or CPU to receive an activation signal (e.g., from a manual trigger, from an external user device, from a display screen of the user interface 87, etc.), output a control signal (e.g., a control signal to a motor and / or piston associated with actuating the bias of the solution out of the respective cartridge and through the respective nozzle) to actuate the delivery of fluid from the syringes 70, 270, 370, 470, 570, and output a control signal to a switch to supply a voltage from a voltage source of the HV module 86 to a respective voltage wire (e.g., wire 92d).

[0158] Memory 1560, in some implementations, can include one or more suitable types of memory (e.g., volatile or non-volatile memory, random access memory (RAM), read only memory (ROM), programmable read only memory (PROM), erasable programmable read only memory (EPROM), electrically erasable programmable read only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.) for storing an operating system, application programs, files containing executable instructions and data. Memory 1560 can also include programs, such as program 1580, that include instructions for completing the processes described herein. For example, the program 1580 may include instructions to receive an activation signal (e.g., from an actuator of the applicator 100, or from, for example, an external user device and / or from a virtual trigger from a display screen of the user interface 87) and output a first control signal to a motor to actuate a piston associated with the actuation of the respective cartridge, and / or output a second control signal to a switch to supply a voltage to a voltage wire from a voltage supply of the HV module 86. Additionally, the controller 1500 may include a data storage device 1590 that may store data relating to parameters for regulating, for example, air flow, fluid flow, and / or voltage of a particular treatment solution.

[0159] 18, 19, 20, 21 are flow diagrams of an exemplary process for operating a reusable applicator 100 and disposable cartridge system 50, 250, 350, 450, 550 according to the present disclosure. Specifically, FIG. 18 is a flow diagram of an exemplary process 1800 for managing the operation of the applicator 100 described herein. In the process 1800, the microcontroller unit may wake up to determine whether setup data is present (step 1802). If so, it may wake up the system of the applicator 100 to execute a main task process (step 1804). The main task process of step 1804 may include a proximity task step 1808, a stepper motor task 1810, a menu task 1812, and an MCU sleep mode 1814. In some aspects, the main task of step 1804 may be initiated upon detecting an input from an accelerometer in communication therewith (e.g., in response to detecting a predetermined change in acceleration above a threshold indicative of a user movement of the applicator 100). In some aspects, a proximity task 1808 may be initiated when a corresponding proximity sensor (e.g., target sensor 45) detects that a target site is within a threshold spray range of applicator 100. In some aspects, a proximity task step 1808 may be initiated by starting and / or stopping actuation of an associated actuator (e.g., a button or capacitive input on a display screen of user interface 87).

[0160] If, in step 1802, the system determines that no setup data is present, then step 1806 of the applicator 100 setup task is performed. In some aspects, step 1806 may include the setup data being entered (e.g., via a display screen of the user interface 87). Once the setup data is entered, a menu task 1812 may be executed. If no actuation or other input is received within a predetermined period of time, then in step 1814 the system enters an MCU sleep mode.

[0161] FIG. 19 is a flow chart of an exemplary process 1900 utilizing certain aspects from process 1800. In process 1900, the microcontroller unit may wake up and initialize all systems and subsystems of the applicator 100 (step 1902). Such initialization may include starting a setup task 1904, a menu task 1906, a main task 1908, a proximity task 1910, a stepper motor task 1912, as well as other initialization tasks. After completing step 1902, a step is performed to read the non-volatile memory 1914, and if the non-volatile memory is not empty (step 1916), the system determines whether all variables have been loaded (step 1918). If all variables have been loaded, the aforementioned main task 1804 of process 1800 may be executed. If the non-volatile memory is empty in step 1916, the system may play a welcome animation on the display screen of the interface 87 (step 1922). Similarly, if it is determined in step 1918 that not all variables have been loaded, then step 1922 may also be performed by the system. Once step 1922 is completed in either situation, the previous setup task step 1806 from process 1800 may be performed after waiting a predetermined period of time (e.g., approximately 3 seconds).

[0162] FIG. 20 is a flow chart of an example process setup task 1806 of the previous process 1800 related to initiating wireless connectivity between the example applicator 100 and a wireless network.

[0163] FIG. 21 is a flowchart of an example process setup task 1812 of the previous process 1800 relating to initiating wireless connectivity between the applicator 100 and an external device (e.g., a mobile computing device such as a smartphone, tablet, etc.) so that the external device can control and / or monitor the operation of one or more aspects of the applicator 100, including, but not limited to, the operation of a cartridge coupled to the applicator.

[0164] FIG. 22 is a flow chart of an example process main task 1804 of the previous process 1800 related to initializing all systems and subsystems of the example applicator 100. FIG. 23 is a flow chart following FIG. 22, specifically illustrating example sub-steps related to determining and managing operations related to a ground strap and any associated ground signal in an example where a ground strap is present. FIG. 23 and FIG. 24 also illustrate example steps related to operations of mounting and managing the assembly of any cartridges described thus far into the example applicator 100 of the present disclosure. By way of example and not limitation, in step 2330 of FIG. 23, the position of the cartridge may be analyzed to determine if the cartridge is properly installed. If not, an animation may be played (step 2332) until eventually the MCU may cause a sleep mode to be executed (step 2336). If the cartridge is determined to be properly installed (step 2330), then in step 2402, the cartridge details may be read to determine certain information, including whether the cartridge is authentic (step 2410), whether the OTP has been blown (step 2412), whether the cartridge identification information is compliant or operational with the current firmware and / or hardware of the applicator 100 (step 2422), and whether the cartridge ID indicates that its contents are sterilized (step 2424), contain stem cells (step 2426), and / or are configured for electrospinning (step 2428). Other aspects of each cartridge may also be identified and evaluated in these exemplary processes. For example, other solution types may be analyzed, as well as the origin and destination of the cartridge, whether its contents remain fully sealed, whether the cartridge has been previously installed in the applicator, the prescribing entity (e.g., whether a physician or other operator has requested the cartridge), and whether the cartridge is associated with a particular patient or intended use.

[0165] Depending on the outcome of a particular sub-step of FIG. 24, the system can proceed to the process of FIG. 25, whereby steps 2502 (system setup for disinfection media), 2504 (system setup for stem cell media), and 2506 (system setup for electrospinning media) initiate the system setup at steps 2508, 2510, and 2512, respectively, and then proceed to the remaining operational tasks of the process 1800 of FIG. 18 described above, as further shown in FIG. 26 and FIG. 27. For example, in FIG. 27, start / stop can be set (step 2702), an OTP bit on the cartridge attached to the applicator 100 can be set (step 2704), and then the applicator stepper can be moved forward depending on the contents (i.e., the media in the contents of the respective cartridge) (step 2706). Thereafter, the proximity task 1808 can be read, and if satisfied, the stepper task 1810 can be executed. In some embodiments, the results of the proximity task 1808 may be displayed on a display screen of the interface 87 and / or may be displayed by one or more LEDs associated therewith.

[0166] FIG. 28 is a flow chart of an example process proximity task 1808 of the previous process 1800 related to sensing and managing operations based on readings from one or more proximity sensors of the applicator 100 and associated calculations.

[0167] FIG. 29 is a flow chart of an example process stepper task 1810 of the previous process 1800 relating to the operation of the stepper motor of the applicator 100 in conjunction with expelling contents from an attached cartridge toward a target site.

[0168] 30 is a flow chart of an example process that may be used before executing the main task 1804 and / or to put the MCU into sleep mode (step 3020). For example, the process may include managing feedback from an accelerometer, manual triggers, start / stop button actuation, ground strap status, signals from the ground strap, the presence of a user ground, and feedback from limit switches.

[0169] 31 is a flow diagram of a method 3100 of operating an exemplary electrostatic applicator system. Step 3110 of method 3100 may include inserting a first disposable cartridge into a chamber housing of the electrostatic applicator system such that a voltage contact at a first end of a voltage wire in the first disposable cartridge contacts a voltage contact of the electrostatic applicator system, a first end of an air supply port in the first disposable cartridge is in fluid communication with an air supply port of the electrostatic applicator system, and a plunger of a syringe containing a first fluid in the first disposable cartridge is aligned with a piston of the electrostatic applicator system. Step 3120 of method 3100 may include actuating a motor with an actuation input to the electrostatic applicator system and delivering an electrical potential to a delivery tube of the first disposable cartridge.

[0170] 32 is a computer-implemented method 3200 for operating an electrostatic applicator system. Step 3210 of method 3200 can include actuating a motor via an activation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of the disposable cartridge removably attached to a chamber housing of the electrostatic applicator system. Step 3220 of method 3200 can include the motor biasing a stopper of the syringe to advance the fluid contents of the disposable cartridge from the syringe through the delivery tube. Step 3230 of method 3200 can include electrostatically charging the fluid contents in the delivery tube via the voltage wire. Step 3240 of method 3200 can include expelling the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site.

[0171] The particular configuration, choice of materials, and size and shape of the various elements may be modified according to the particular design specifications or constraints required for a system or method constructed according to the principles of the disclosed technology. Such modifications are intended to be encompassed within the scope of the disclosed technology. The embodiments disclosed herein are therefore considered in all respects to be illustrative and not restrictive. Thus, it will be apparent from the above that, while particular forms of the disclosure have been illustrated and described, various modifications can be made without departing from the spirit and scope of the disclosure, and all modifications that come within the meaning and range of equivalents thereof are intended to be included.

[0172] The following clauses list non-limiting embodiments of the present disclosure. 1. A disposable fluid delivery system for an electrostatic applicator, comprising: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a voltage wire including a contact in communication with a delivery tube in fluid communication with the delivery outlet, the voltage wire in electrical communication with the high voltage module and configured to electrostatically charge the fluid contents in the delivery tube; a syringe including a barrel portion and a plunger configured to advance a fluid from within the barrel portion and through a delivery tube; a cartridge housing at least partially enclosing the nozzle housing, the voltage wire, and the syringe; Including, the system. 2. The disposable fluid delivery system of clause 1, further comprising a voltage tube in electrical communication with the voltage port, the voltage wire passing between a contact in communication with the delivery tube and a contact port in the wall of the cartridge housing. 3. The disposable fluid delivery system of clause 2, wherein the voltage tube and voltage wire comprise a generally S-shaped configuration. 4. The disposable fluid delivery system of clause 2, wherein the voltage tube and the voltage wire comprise a straight shape. 5. The disposable fluid delivery system of clause 2, wherein the voltage tube and voltage wire comprise a generally curved shape. 6. The disposable fluid delivery system of clause 2, further comprising an air supply tube connected to the air supply port. 7. The disposable fluid delivery system of clause 2, wherein the syringe contains contents comprising one or more of a disinfectant, a germicidal solution, a painkiller, an exosome, a biologic, and / or a liquid dressing solution. 8. The disposable fluid delivery system of clause 2, wherein the analgesic comprises one or more of lidocaine, levobupivacaine, acemetacin, ketorolac and ceftazidime. 9. The disposable fluid delivery system of clause 2, wherein the biologic comprises one or more of stem cells and / or mammalian cells. 10. The disposable fluid delivery system of clause 2, wherein the disinfecting and / or germicidal solution comprises chlorhexidine gluconate and / or povidone iodine. 11. The disposable fluid delivery system of clause 1, wherein the cartridge housing is a moldable plastic material. 12. The disposable fluid delivery system of clause 11, wherein the cartridge housing comprises multiple sections of moldable plastic connectable to create a single integral component. 13. The disposable fluid delivery system of clause 1, wherein the voltage wire contact includes a wire loop that at least partially surrounds the outer surface of the delivery tube to provide a potential of about 1 V to about 40 kV. 14. The disposable fluid delivery system of clause 1, wherein the contacts of the voltage wire are in physical contact with the outer surface of the delivery tube to provide a potential of about 1 V to about 40 kV. 15. The disposable fluid delivery system of clause 1, wherein the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and expel fluid that is uniformly charged by the voltage wire. 16. A reusable electrostatic applicator including a cartridge chamber sized and shaped to receive a cartridge housing, a high voltage module configured to be in electrical communication with the voltage wires; a piston disposed adjacent the cartridge chamber and configured to advance a plunger enclosed within the cartridge housing when the cartridge housing is assembled with the cartridge chamber; Reusable electrostatic applicators, including 2. The disposable fluid delivery system of claim 1, further comprising: 17. A reusable electrostatic applicator is a motor configured to move a piston; one or more processors; When executed by the one or more processors, the method includes: Receive the activation signal, outputting a control signal to a motor to operate the piston; Cause the switch to output a control signal to supply voltage from the high voltage module to the voltage wire A memory for storing instructions; 17. The disposable fluid delivery system of clause 16, comprising: 18. The disposable fluid delivery system of clause 17, wherein the motor is a stepper motor, a linear actuator, a worm gear motor, and / or a planetary gear motor. 19. The disposable fluid delivery system of clause 17, wherein the motor is a drivable actuator system that uses motion transmission through an applied force. 20. The disposable fluid delivery system of clause 17, wherein the reusable electrostatic applicator further includes a display screen, and the activation signal is a user input to the display screen. 21. The disposable fluid delivery system of clause 17, wherein the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator. 22. A reusable electrostatic applicator is a housing base containing a voltage source; a device housing including a cartridge chamber; a handle extending between the housing base and the device housing; 22. The disposable fluid delivery system of claim 21, comprising: 23. The disposable fluid delivery system of clause 22, wherein the cartridge chamber is positioned within the device housing such that the actuator is positioned below the cartridge chamber relative to the horizontal. 24. The disposable fluid delivery system of clause 17, wherein the reusable electrostatic applicator further includes a wireless antenna, and the activation signal is a wireless signal received from a remote external user device. 25. An electrostatic applicator system for delivering a treatment solution to a target site, comprising: A device housing configured to be handheld; a motor within the device housing configured to drive the piston; a voltage source within the device housing; a high voltage module electrically connected to a voltage source; Cartridge chamber and a portable, reusable electrostatic applicator comprising: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a voltage wire including a contact in fluid communication with a delivery tube in fluid communication with the delivery outlet; a syringe including a barrel portion and a plunger configured to advance a fluid from within the barrel portion and through a delivery tube; a cartridge housing at least partially enclosing the nozzle housing, the voltage wire, and the syringe; a disposable cartridge removably insertable into the cartridge chamber, Including, the system. 26. The electrostatic applicator system of clause 25, wherein the syringe contains a fluid comprising one or more of a disinfectant, a germicidal solution, a painkiller, an exosome, a biologic, and / or a liquid dressing solution. 27. The electrostatic applicator system of clause 26, wherein the analgesic comprises one or more of lidocaine, levobupivacaine, acemetacin, ketorolac and ceftazidime. 28. The electrostatic applicator system of clause 26, wherein the biologic comprises one or more of stem cells and / or mammalian cells. 29. An electrostatic applicator system as described in clause 25, wherein the voltage wires and voltage tubes include voltage wires having a straight shape and / or a curved shape or a generally S-shaped shape within the cartridge housing. 30. An electrostatic applicator system as described in clause 25, wherein the cartridge housing is a moldable plastic material. 31. The electrostatic applicator system of claim 30, wherein the cartridge housing comprises a plurality of connected sections of moldable plastic. 32. The cartridge chamber includes a wall including a high voltage contact in electrical communication with the high voltage module and an air supply port in fluid communication with a pump disposed within the device housing; a voltage wire in electrical communication with the high voltage contact in the wall; A contact of the voltage wire is in physical contact with the exterior surface of the delivery tube to provide a potential of about 1 V to about 40 kV. 26. An electrostatic applicator system as claimed in claim 25. 33. An electrostatic applicator system as described in clause 25, wherein the HV module comprises a plurality of rotating diodes such that the HV module is configured to generate both positive and negative high voltages depending on the orientation of the rotating diodes. 34. An electrostatic applicator system as described in clause 25, wherein the HV module comprises a circuit board including a first positive high voltage multiplier system and a second negative high voltage multiplier system. 35. An electrostatic applicator system as described in clause 25, wherein the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and expel fluid that is uniformly charged by the voltage wire. 36. An electrostatic applicator system as described in clause 25, wherein the disposable cartridge includes an air supply tube connected to the air supply port. 37. An electrostatic applicator system as described in clause 25, wherein the device housing includes a handle, the voltage source is disposed within a housing base of the device housing, and the handle is disposed between the device housing and the housing base. 38. A reusable electrostatic applicator is one or more processors; When executed by the one or more processors, the method includes: Receive the activation signal, Outputs control signals to motors that control (a) the electrical potential from the high voltage module through the voltage wires to the delivery tube, (b) the position of the piston and plunger of the disposable cartridge, and / or (c) a pump that regulates the air flow from the device housing to the air supply port. A memory for storing instructions; 26. The electrostatic applicator system of claim 25, comprising: 39. The disposable cartridge includes an on-board memory that contains information regarding one or more operating parameters of the contents stored within the syringe and / or another fluid reservoir of the disposable cartridge; one or more processors of the reusable electrostatic applicator are configured to communicate with the on-board memory to obtain information regarding the contents of the disposable cartridge and to control at least one of a flow rate, an electrical potential, and a nozzle setting; 39. An electrostatic applicator system as claimed in claim 38. 40. The disposable cartridge includes an on-board memory that contains information regarding characteristics of contents stored in the syringe and / or another fluid reservoir of the disposable cartridge; one or more processors of the reusable electrostatic applicator are configured to communicate with the on-board memory to obtain information regarding the contents of the disposable cartridge and to control motor speed, air intake, and / or applied voltage; 39. An electrostatic applicator system as claimed in claim 38. 41. An electrostatic applicator system as described in clause 39, wherein the memory is incorporated into the processor of the electrostatic applicator system and contains operating instructions for operating the electrostatic applicator system. 42. An electrostatic applicator system as described in clause 39, wherein the near field communication (NFC) tag includes a memory. 43. The electrostatic applicator system of clause 42, further comprising a display screen, and wherein the activation signal is a user input to the display screen. 44. The method according to claim 1, further comprising: Reading NFC information regarding operating parameters of the disposable cartridge; Displaying the read NFC information on the display screen 43. The electrostatic applicator system of claim 42, further comprising: 45. The electrostatic applicator system of clause 38, further comprising an actuator, the activation signal being a user input received by the actuator. 46. ​​An electrostatic applicator system as described in clause 38, further comprising a wireless antenna, and wherein the activation signal is a wireless signal received from an external user device. 47. The electrostatic applicator system of clause 38, further comprising an accelerometer configured to output a movement signal to the one or more processors in response to detecting movement of the electrostatic applicator system. 48. An electrostatic applicator system as described in clause 47, further comprising a display screen on the electrostatic applicator system that is activated by a wake signal from the one or more processors in response to the one or more processors receiving a movement signal, the activation signal being a user input to the display screen. 49. The electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target; one of the control signals is output to the motor in response to the distance being within a predetermined distance threshold; one of the control signals is output to a switch to control a voltage of the electrostatic applicator system in response to the distance being within a predetermined distance threshold. 39. An electrostatic applicator system as claimed in claim 38. 50. An electrostatic applicator system as described in clause 38, wherein the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target, and wherein one of the control signals is output in response to the distance being greater or less than a predetermined distance threshold to prevent operation of the motor. 51. An electrostatic applicator system as described in clause 38, wherein the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target, and one of the control signals is output to a switch to prevent delivery of voltage of the electrostatic applicator system in response to the distance being greater or less than a predetermined distance threshold. 52. A method for operating an electrostatic applicator system, comprising: a voltage contact at a first end of a voltage wire in the first disposable cartridge contacts a voltage contact of the electrostatic applicator system; a first end of an air supply port in the first disposable cartridge in fluid communication with an air supply of the electrostatic applicator system; a plunger of a syringe containing a first fluid in a first disposable cartridge aligned with a piston of the electrostatic applicator system; Inserting a first disposable cartridge into a chamber housing of an electrostatic applicator system; an actuation input to the electrostatic applicator system actuating a motor and delivering an electrical potential to a delivery tube of a first disposable cartridge; A method comprising: 53. The method of claim 52, wherein the motor is actuated to advance the first fluid from the syringe through a delivery tube and spray it as electrostatically charged atomized fluid droplets in a predetermined spray pattern onto the target site. 54. Removing the first disposable cartridge from the chamber housing; inserting a second disposable cartridge into the chamber housing, the second disposable cartridge containing a second fluid; 53. The method of claim 52, further comprising: 55. A second disposable cartridge is configured for electrospinning, the method comprising: and actuating a motor with a second actuation input to the electrostatic applicator system and delivering an electrical potential to the delivery tube of the second disposable cartridge such that a second fluid in the syringe of the second disposable cartridge is delivered from the second fluid through the delivery tube of the second disposable cartridge to the target site as electrospun fibers. 55. The method of claim 54, further comprising: 56. The method of claim 54, wherein the first disposable cartridge and the second disposable cartridge each include an on-board memory containing information regarding operating parameters of the first fluid and the second fluid, respectively, and insertion of either the first disposable cartridge or the second disposable cartridge into the chamber housing causes the operating parameters to be transmitted to the memory of the electrostatic applicator system, the operating parameters including at least one of the speed of the motor of the respective disposable cartridge, the air intake, and the voltage applied to the delivery tube. 57. The method is Upon insertion of one of the first disposable cartridge or the second disposable cartridge into the chamber housing, tagging the first disposable cartridge or the second disposable cartridge in a registry associated with information of an operating parameter of the first disposable cartridge or the second disposable cartridge as being a used cartridge; preventing the motor from operating and / or the electrical potential from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge upon determining that the first disposable cartridge or the second disposable cartridge is a used cartridge; 57. The method of claim 56, further comprising: 58. The method of clause 54, wherein the first disposable cartridge and the second disposable cartridge contain different fluids. 59. The method of clause 49, wherein the first disposable cartridge and the second disposable cartridge include at least one of different voltage wires and different delivery tubes depending on the respective nozzle housing, the first fluid stored in the respective disposable cartridge, and / or the second fluid. 60. The method of clause 52, wherein providing the activation input includes inputting information about the first fluid to a display screen of the electrostatic applicator system and providing the input to the display screen. 61. The method of clause 52, further comprising pairing the electrostatic applicator system to an external user device via a short-range wireless connection, and providing an activation input comprises inputting information about the first fluid into the external user device and providing the input to a display screen of the external user device. 62. A computer-implemented method for operating an electrostatic applicator system, comprising: actuating a motor via an actuation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system through a voltage wire of the disposable cartridge to a delivery tube of the disposable cartridge removably attached to a chamber housing of the electrostatic applicator system; a motor biasing a plunger of the syringe to advance the fluid contents of the disposable cartridge from the syringe through a delivery tube; electrostatically charging the fluid contents in the delivery tube by a voltage wire; Discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site; A method comprising: 63. Electrostatically charging the fluid contents in the barrel portion of the syringe proximal to the delivery tube by a voltage wire. 63. The computer implemented method of claim 62, further comprising: 64. The computer-implemented method of claim 62, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air supply of an electrostatic applicator system into the disposable cartridge so as to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto the target site. 65. The computer-implemented method of claim 62, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers. 66. Detecting the distance between the electrostatic applicator system and the intended target by a proximity sensor; in response to the distance being within a predetermined distance threshold, sending an actuation input to operate the motor and / or deliver an electrical potential to the high voltage module; 63. The computer implemented method of claim 62, further comprising: 67. Detecting the distance between the electrostatic applicator system and the intended target by a proximity sensor; and in response to the distance being greater than or less than a predetermined distance threshold, preventing operation of the motor and / or preventing the high voltage module from delivering an electrical potential. 63. The computer implemented method of claim 62, further comprising: 68. Initiating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the motion signal; in response to the wake signal, sending an activation input to operate the motor and / or deliver an electrical potential to the high voltage module; 63. The computer implemented method of claim 62, further comprising: 69. The disposable cartridge includes an on-board memory containing information regarding operating parameters of the fluid contents stored in the syringe, and the method includes: communicating with the on-board memory by one or more processors of the reusable electrostatic applicator to obtain information regarding the fluid contents of the disposable cartridge; Controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including a motor speed, an air intake, and / or an applied voltage of the disposable cartridge; 63. The computer implemented method of claim 62, further comprising: 70. A computer implemented method according to clause 62, wherein the memory is incorporated into a processor of the electrostatic applicator system and contains operating instructions of the computer implemented method for operating the electrostatic applicator system. 71. A system for operating an electrostatic applicator system, comprising: at least one memory storing instructions; actuating a motor via an actuation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of a disposable cartridge removably attached to a cartridge housing of the electrostatic applicator system; a motor biasing a plunger of the syringe to advance the fluid contents of the disposable cartridge from the syringe through a delivery tube; electrostatically charging the fluid contents within the delivery tube by a voltage wire; Discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site; at least one processor configured to execute instructions to cause the device to perform operations including: Including, the system. 72. The system described in clause 71, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air supply of an electrostatic applicator system into the disposable cartridge so as to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto the target site. 73. The system described in clause 71, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers at a predetermined rate onto the target site. 74. An operation comprising detecting a distance between an electrostatic applicator system and an intended target by a proximity sensor; in response to the distance being within a predetermined distance threshold, sending an actuation input to operate the motor and / or deliver an electrical potential to the high voltage module; 72. The system of claim 71, further comprising: 75. An operation comprising initiating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the motion signal; in response to the wake signal, sending an activation input to operate the motor and / or deliver an electrical potential to the high voltage module; 72. The system of claim 71, further comprising: 76. The disposable cartridge includes an on-board memory containing information regarding one or more operating parameters of the fluid contents stored within the syringe, and the operation is communicating with the on-board memory by one or more processors of the reusable electrostatic applicator to obtain information regarding the fluid contents of the disposable cartridge; Controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including a motor speed, an air intake, and / or an applied voltage of the disposable cartridge; 72. The system of claim 71, further comprising: 77. A system as described in clause 71, wherein the memory is incorporated into the processor of the electrostatic applicator system and contains operating instructions of a computer implemented method for operating the electrostatic applicator system. 78. A non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to perform a method for operating an electrostatic applicator system, the method comprising: actuating a motor via an actuation input to the electrostatic applicator system and / or delivering an electrical potential from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge to a delivery tube of a disposable cartridge removably attached to a system housing of the electrostatic applicator system; a motor biasing a plunger of the syringe to advance the fluid contents of the disposable cartridge from the syringe through a delivery tube; electrostatically charging the fluid contents within the delivery tube by a voltage wire; Discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site; A non-transitory computer readable medium comprising: 79. The non-transitory computer readable medium of clause 78, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from an air supply of an electrostatic applicator system into the disposable cartridge so as to atomize the electrostatically charged fluid contents into droplets in a predetermined spray pattern onto an oppositely charged target site. 80. The non-transitory computer-readable medium of clause 78, wherein the step of expelling the electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers at a predetermined rate and / or pattern onto an oppositely charged target site. 81. The method is detecting a distance between the electrostatic applicator system and an intended target with a proximity sensor; in response to the distance being within a predetermined distance threshold, sending an actuation input to operate the motor and / or deliver an electrical potential to the high voltage module; 79. The non-transitory computer readable medium of claim 78, further comprising: 82. The method is initiating a wake signal from the one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to the one or more processors receiving the movement signal; in response to the wake signal, sending an activation input to operate the motor and / or deliver an electrical potential to the high voltage module; 79. The non-transitory computer readable medium of claim 78, further comprising: 83. The disposable cartridge includes an on-board memory containing information regarding one or more operating parameters of the fluid contents stored in the syringe, and the method includes: communicating with the on-board memory by one or more processors of the reusable electrostatic applicator to obtain information regarding the fluid contents of the disposable cartridge; Controlling at least one of a flow rate, an electrical potential, and a nozzle setting to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including a motor speed, an air intake, and / or an applied voltage of the disposable cartridge; 79. The non-transitory computer readable medium of claim 78, further comprising:

Claims

1. 1. A disposable fluid delivery system for an electrostatic applicator, comprising: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a delivery tube assembled with the delivery outlet, the delivery tube being in fluid communication with the delivery outlet; a voltage wire assembled with the voltage port, the voltage wire including a contact in electrical communication with the delivery tube, the voltage wire in electrical communication with a high voltage module, and configured to electrostatically charge a fluid content in the delivery tube; a syringe including a barrel portion and a plunger configured to advance fluid from within the barrel portion through the delivery tube; a cartridge housing at least partially enclosing the nozzle housing, the voltage wire, and the syringe; 1. A disposable fluid delivery system comprising:

2. a voltage tube in electrical communication with the voltage port; The disposable fluid delivery system of claim 1 , wherein the voltage wire passes between the contact in communication with the delivery tube and a contact port in a wall of the cartridge housing.

3. 3. The disposable fluid delivery system of claim 2, wherein the syringe contains contents comprising one or more of an antiseptic, a germicidal solution, a pain reliever, an exosome, a biologic, and / or a liquid dressing solution.

4. the cartridge housing being a moldable plastic material; The disposable fluid delivery system of claim 1 , wherein the cartridge housing comprises multiple connectable sections of moldable plastic.

5. 10. The disposable fluid delivery system of claim 1, wherein the contact of the voltage wire comprises a wire loop that at least partially surrounds an exterior surface of the delivery tube to provide a potential of about 1V to about 40 kV.

6. The disposable fluid delivery system of claim 1 , wherein the contact of the voltage wire is in physical contact with the delivery tube to provide a potential of about 1 V to about 40 kV.

7. 2. The disposable fluid delivery system of claim 1, wherein the delivery tube, when assembled with the syringe and the nozzle housing, is configured to receive fluid from the barrel portion of the syringe and expel fluid that is uniformly charged by the voltage wire.

8. a reusable electrostatic applicator including a cartridge chamber sized and shaped to receive said cartridge housing; The reusable electrostatic applicator comprises: a high voltage module configured to be in electrical communication with the voltage wires; a piston disposed proximate to the cartridge chamber, the piston configured to advance the plunger enclosed within the cartridge housing when the cartridge housing is assembled with the cartridge chamber; The disposable fluid delivery system of claim 1 , comprising:

9. The reusable electrostatic applicator comprises: a motor configured to move the piston; a controller including one or more processors; A memory for storing instructions; Equipped with The instructions, when executed by the one or more processors, cause the reusable electrostatic applicator to: receiving an activation signal from the controller to wake up the reusable electrostatic applicator; outputting a control signal from the controller to the motor to operate the piston; The disposable fluid delivery system of claim 8 , further comprising a switch that outputs a control signal from said controller to supply a voltage from said high voltage module to said voltage wire.

10. The reusable electrostatic applicator comprises: a housing base containing a voltage source; a device housing containing the cartridge chamber; a handle extending between the housing base and the device housing; The disposable fluid delivery system of claim 9 , comprising:

11. The disposable fluid delivery system of claim 1, wherein the air supply port, the voltage port, and the delivery outlet are integrally formed in the nozzle housing.

12. 1. An electrostatic applicator system for delivering a treatment solution to a target site, comprising: a portable, reusable electrostatic applicator; Disposable cartridges and Including, The portable, reusable electrostatic applicator comprises: A device housing configured to be handheld; a motor within the device housing configured to drive a piston within the device housing; a voltage source within the device housing; a high voltage module electrically connected to the voltage source; Cartridge chamber and Including, the disposable cartridge is removably insertable into the cartridge chamber; The disposable cartridge comprises: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a delivery tube assembled with the delivery outlet, the delivery tube being in fluid communication with the delivery outlet; a voltage wire assembled with the voltage port, the voltage wire including a contact in electrical communication with the delivery tube; a syringe including a barrel portion and a plunger configured to advance fluid from within the barrel portion and through the delivery tube; a cartridge housing at least partially enclosing the nozzle housing, the voltage wire, and the syringe; 1. An electrostatic applicator system comprising:

13. the cartridge chamber includes a wall; The wall is a high voltage contact in electrical communication with the high voltage module; an air supply port in fluid communication with a pump disposed within the device housing; Including, the voltage wire is in electrical communication with the high voltage contact on the wall; The electrostatic applicator system of claim 12 , wherein the contact of the voltage wire is in physical contact with an exterior surface of the delivery tube to provide a potential of about 1 V to about 40 kV.

14. 13. The electrostatic applicator system of claim 12, wherein the delivery tube, when assembled with the syringe and the nozzle housing, is configured to receive fluid from the barrel portion of the syringe and expel fluid that is uniformly charged by the voltage wire.

15. 13. The electrostatic applicator system of claim 12, wherein the high voltage module comprises a plurality of the rotating diodes such that the high voltage module is configured to generate both positive and negative high voltages depending on the orientation of the rotating diodes.

16. 13. The electrostatic applicator system of claim 12, wherein the high voltage module comprises a circuit board including a first positive high voltage multiplier system and a second negative high voltage multiplier system.

17. The reusable electrostatic applicator comprises: a controller including one or more processors; A memory for storing instructions; Including, The instructions, when executed by the one or more processors, cause the reusable electrostatic applicator to: receiving an activation signal from the controller to wake up the reusable electrostatic applicator; outputting control signals to a motor of the reusable electrostatic applicator that controls (a) an electrical potential from the high voltage module to the delivery tube via the voltage wires, (b) a position of the piston of the reusable electrostatic applicator and the plunger of the disposable cartridge, and / or (c) a pump of the reusable electrostatic applicator that regulates air flow from the device housing to the air supply port; The electrostatic applicator system of claim 12 , further comprising:

18. the disposable cartridge includes an on-board memory that includes information regarding one or more operating parameters of contents stored in the syringe and / or another fluid reservoir of the disposable cartridge; 20. The electrostatic applicator system of claim 17, wherein the one or more processors of the reusable electrostatic applicator are configured to communicate with the embedded memory to obtain information regarding the contents of the disposable cartridge and to control at least one of a flow rate of the contents, the electrical potential, and the air flow.

19. an accelerometer configured to output a motion signal to the one or more processors in response to detecting motion of the electrostatic applicator system; a display screen on the device housing activated by the one or more processors in response to the one or more processors receiving the motion signal; and Further equipped with 20. The electrostatic applicator system of claim 18, wherein the activation signal is a user input to the display screen.

20. 1. A method of operating an electrostatic applicator system, comprising: Inserting the disposable fluid delivery system of claim 1 into a chamber housing of the electrostatic applicator system; an actuation input to the electrostatic applicator system causes a motor that drives the plunger of the disposable fluid delivery system and delivers an electrical potential to the delivery tube of the disposable fluid delivery system; Including, By said insertion, the contact at the first end of the voltage wire contacts a voltage contact on the chamber housing of the electrostatic applicator system; the air supply port in the disposable fluid delivery system is in fluid communication with an air supply port of the electrostatic applicator system; The method, wherein the plunger of the syringe containing a first fluid in the disposable fluid delivery system is aligned with a piston of the electrostatic applicator system.

21. the disposable fluid delivery system includes an on-board memory containing information regarding an operating parameter of the first fluid; Inserting the disposable fluid delivery system into the chamber housing causes the operating parameters to be transmitted to a memory of an electrostatic applicator system; 21. The method of claim 20, wherein the operating parameters include at least one of: a speed of the motor of the disposable fluid delivery system, air intake into the disposable fluid delivery system, and a voltage applied to the delivery tube.

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