Oral composition

Abstract

To provide a composition for an oral cavity that is capable of suppressing an undesirable aftertaste derived from a plant extract, improves a feeling of stickiness, and imparts a good refreshing feeling.SOLUTION: A composition for an oral cavity contains (A) a plant extract, and (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Conventionally, in order to suppress bad breath, bactericides for killing bacteria that cause bad breath, deodorants, and generation inhibitors for suppressing the generation of substances that cause bad breath have been used, and oral compositions containing these have been proposed.

[0003] Plant extracts are known as components for suppressing bad breath, and various oral compositions containing plant extracts as active ingredients for preventing bad breath have been proposed (see Patent Documents 1 to 3 below). Oral compositions containing such plant extracts as active ingredients are effective in suppressing bad breath caused by components that cause bad breath, such as volatile sulfur and methyl mercaptan.

[0004] Furthermore, even when there is no bad breath (bad breath) that can actually be detected by others, there are an increasing number of cases in which people are concerned about bad breath due to discomfort in the oral cavity. In order to eliminate such concerns about bad breath, oral compositions utilizing plant extracts and N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide and / or N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide have been proposed (see Patent Document 4 below). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2005-289918 A [Patent Document 2] Patent No. 5776364 [Patent Document 3] JP 2016-112634 A [Patent Document 4] International Publication No. 2018 / 221621 Summary of the Invention [Problem to be solved by the invention]

[0006] However, with the oral compositions disclosed in the above patent documents, even after using the oral composition and rinsing the mouth, an aftertaste derived from the plant extract remains in the oral cavity, and there are cases in which the user is unable to fully experience the effect of suppressing bad breath.

[0007] Therefore, an object of the present invention is to provide an oral composition that can suppress the unpleasant aftertaste caused by plant extracts even when the plant extracts are used as bad breath suppressing ingredients, and further improves the feeling of stickiness and provides an excellent feeling of freshness. [Means for solving the problem]

[0008] That is, the present invention provides the following [1] to [7]. [1] (A) a plant extract, (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide An oral composition comprising: [2] The oral composition according to [1], wherein (A) the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria Root, carrot, sage, licorice, Angelica Root, persimmon, sword bean, olive, tea, magnolia, Phellodendron Amurense, Japanese spicebush, Chinese pepper, thyme, birch, peony, Quercus salicina, Asarum, turmeric, clove, stevia, Sapindus mukorossi, marjoram, melissa, perilla, laurel, eucalyptus, cola, Monk fruit, camellia, clove, allspice, Sappan, Lithospermum Root, Rhubarb, Forsythia Suspensa, Tangerine Peel, Cinnamon Bark, oregano, basil, Lonicera Root, Peony Pea, and Myrobalan. [3] The oral composition described in [2], wherein (A) the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, sage, licorice, Angelica acutiloba, persimmon, sword bean, olive, tea, and Phellodendron amplexicaule. [4] (A) A plant extract is contained in an amount of 0.00001 to 0.05% by mass as a pure extract content, (B) The oral composition according to any one of [1] to [3], which contains 0.00001 to 0.1 mass % of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide. [5] The oral composition according to any one of [1] to [4], wherein the mass ratio of the content of (A) plant extract (pure extract content) to the content of (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide is 0.02 to 100. [6] The oral composition described in any one of [1] to [5], which is a toothpaste or a mouthwash. [7] The oral composition according to [6], which is a dentifrice and further contains 8 to 70 mass% of an abrasive (C). Effect of the Invention

[0009] According to the present invention, it is possible to provide an oral composition which can suppress the unpleasant aftertaste caused by plant extracts even when plant extracts are used, and further improve the feeling of stickiness, thereby imparting an excellent feeling of freshness. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The present invention will be described in detail below. The oral composition of the present invention is an oral composition containing (A) a plant extract and (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, and may further contain (C) an abrasive.

[0011] First, components (A) to (C) that may be contained in the oral cavity composition of this embodiment will be described.

[0012] [(A) Plant extract] The "(A) component" according to an embodiment of the present invention is a plant extract. The plant extract is an extract obtained by extracting a plant as a raw material.

[0013] Component (A) is a component that can reduce and improve the sticky feeling in the oral cavity, especially when used in combination with component (B) described below.

[0014] The plant from which the component (A) is derived is preferably one from which a plant extract having antibacterial, deodorant, or anti-inflammatory effects can be obtained.Examples of the plant from which the component (A) is derived include rosemary, Scutellaria root, carrot, sage, licorice, Japanese angelica, persimmon (particularly persimmon tannin), sword bean, olive (particularly olive leaf), tea, magnolia, Phellodendron amplexicaule (particularly Phellodendron bark), Japanese spicebush, Japanese pepper, thyme, white birch, peony, Quercus salicina, Asarum, turmeric, clove, stevia, Soapberry, marjoram, melissa, perilla, laurel, eucalyptus, cola, Monk fruit, camellia, clove, allspice, Suo, Lithospermum root, Rhubarb, Forsythia, Tangerine, Cinnamon, Oregano, basil, Lonicera japonica, Peony seed, and Myrobalan.

[0015] In this embodiment, the component (A) is preferably an extract of one or more plants selected from the group consisting of the above examples of plants.

[0016] Among these, it is more preferable that component (A) is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, sage, licorice, Angelica acutiloba, persimmon, sword bean, olive, tea, and Phellodendron amplexicaule.

[0017] The extraction of the plant extract from the above-mentioned exemplified plants can be performed by employing any suitable method known in the art, and can be performed by employing any suitable extraction conditions known in the art.

[0018] In this embodiment, the plant extract, which is component (A), can be specifically produced, for example, by extracting the raw material, which is made by grinding the above-mentioned plants, particularly the leaves and stems, into a powder using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent as an extraction solvent.

[0019] Examples of extraction solvents include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethanol, propanol, isopropanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin; non-polar solvents such as n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, and benzene; and mixed solvents thereof.

[0020] The extraction solvent is preferably a hydrophilic solvent, and the component (A) of the present invention is preferably a hydrophilic solvent extract. The hydrophilic solvent is preferably water, a lower monohydric alcohol having 1 to 5 carbon atoms (especially methanol, ethanol, propanol, isopropanol, etc.), glycol (especially propylene glycol, butylene glycol, etc.), or a mixed solvent thereof.

[0021] The mixed solvent is preferably a mixed solvent in which the mixing ratio (mass ratio) of water to a lower monohydric alcohol or glycol is 10:90 to 90:10. The extraction solvent may be composed of only water.

[0022] In addition, the extraction residue after the extraction treatment using the above raw material and the above extraction solvent may be used as a further raw material, and a plant extract obtained by further extraction treatment using the above extraction solvent may also be used as component (A). Note that a commercially available plant extract may also be used as component (A).

[0023] In this embodiment, the content of the (A) component in the entire oral composition (100% by mass) is 0.00001 to 0.05% by mass, preferably 0.0001 to 0.005% by mass, and more preferably 0.0002 to 0.005% by mass, in terms of the pure extract content excluding the extraction solvent, from the viewpoint of improving the sticky feeling and suppressing irritation in the oral cavity. When the (A) component content is 0.00001% by mass or more, the sticky feeling can be sufficiently reduced, and when it is 0.05% by mass or less, irritation in the oral cavity during use can be reduced.

[0024] [(B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide] Component (B) is N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.

[0025] In this embodiment, the blending amount of the (B) component is preferably 0.00001 to 0.1 mass% and more preferably 0.00005 to 0.005 mass% in the entire oral composition from the viewpoints of improving the stickiness, imparting a refreshing feeling, and suppressing irritation in the oral cavity and a bad aftertaste. When the content of the (B) component is 0.00001 mass% or more, the stickiness can be sufficiently reduced, and when it is 0.1 mass% or less, irritation in the oral cavity during use can be reduced and the aftertaste can be improved.

[0026] [Content ratio] -(A) / (B)- The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.0001 or more, preferably 0.02 or more, and more preferably 0.1 or more. (A) / (B) is 5000 or less, preferably 100 or less, and more preferably 20 or less. By doing so, it is possible to improve the stickiness, impart a refreshing feeling, and suppress irritation in the oral cavity and a bad aftertaste. Therefore, (A) / (B) is 0.0001 to 5000, preferably 0.02 to 100, and more preferably 0.1 to 100.

[0027] [(C) Abrasive] The "(C) component" according to the embodiment of the present invention is an abrasive. The (C) component can be suitably used when the oral composition of the present embodiment is a dentifrice (toothpaste).

[0028] The abrasive may be either an inorganic abrasive or an organic abrasive. The preferred RDA value (Radioactive Dentine Abrasion value) of the abrasive is not particularly limited, but is usually 50 or more, particularly 50 to 200. Examples of inorganic abrasives include calcium phosphate-based compounds such as dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, and calcium pyrophosphate; abrasive silica such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite. Examples of organic abrasives include synthetic resin-based abrasives and polymethyl methacrylate.

[0029] In the oral cavity composition of this embodiment, one or more of the above-listed abrasives can be blended as component (C). Among these, component (C) is preferably an inorganic abrasive, more preferably an abrasive silica mainly composed of silicate such as precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, or a calcium carbonate-based abrasive, and particularly preferably an abrasive silica such as precipitated silica. As the abrasive silica, commercially available products can be used, such as Zeodent (registered trademark) 124 and Zeodent (registered trademark) 113 manufactured by Evonic, TIXOSIL (registered trademark) 73 and TIXOSIL (registered trademark) 63 manufactured by Solvay, and abrasive silica, zirconosilicate, aluminosilicate, etc. manufactured by Taki Chemical Co., Ltd.

[0030] The abrasive silica is preferably abrasive particles having an average particle size of 1 to 40 μm, and the BET specific surface area of ​​the abrasive silica is preferably 80 to 250 square meters per gram. Here, the average particle size of the abrasive silica is the volume-based median size (D50) measured by a laser diffraction / scattering method.

[0031] The blending amount of the abrasive (C) component is preferably 8% by mass or more, more preferably 10% by mass or more, based on the total amount of the oral composition. In this way, it is possible to impart an appropriate viscosity, ensure good shape retention, and realize a good feeling of use. The upper limit is preferably 70% by mass or less, more preferably 50% by mass or less. This makes it possible to suppress an increase in the viscosity of the oral composition, maintain good shape retention, and realize a good feeling of use. Therefore, the content of the (A) component is preferably 8 to 70% by mass, more preferably 10 to 50% by mass.

[0032] The abrasive component (C) may be granular, and granules may be blended as an abrasive component. The granules as component (C) may be, for example, particles obtained by granulating water-insoluble powder into granules, granules obtained by crushing silica gel, or granules obtained by using any suitable conventional binder for granulation. The abrasive component (C) may be a combination of abrasive particles having a particle size of 1 to 40 μm as described above and granules.

[0033] In this specification, the content of each component is based on the amount of each component charged when producing the oral composition.

[0034] [Optional ingredients] The oral cavity composition of this embodiment may contain optional components other than the components (A) to (C) already explained, as long as the effects of the present invention are not impaired.

[0035] In the case where the oral composition is a toothpaste, the optional components include, for example, a solvent, a surfactant, a sweetener, a flavoring, a medicinal component, an oily component, a preservative, a humectant, a binder, a pH adjuster, and a colorant (pigment). In the case where the oral composition is a mouthwash, the optional components include, for example, a humectant, a surfactant, a sweetener, a preservative, a pH adjuster, a flavoring, and a medicinal component. The following is a detailed explanation.

[0036] -solvent- The oral cavity composition of the present embodiment may further contain a solvent, preferably water (purified water) or ethanol.

[0037] -Surfactants- The oral composition of the present embodiment may further contain a surfactant. Examples of the surfactant that can be used in the oral composition include anionic surfactants, nonionic surfactants, and amphoteric surfactants.

[0038] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl group and acyl group may be either linear or branched, and may be either saturated or unsaturated, and the number of carbon atoms is usually 10 to 20, preferably 12 to 18, and more preferably 12 to 14. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of such salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among them, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0039] Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurate salts include lauroyl methyl taurate, N-methyl-N-acyltaurate salt, and N-cocoyl methyl taurate salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 18 carbon atoms, such as tetradecene sulfonate salt. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0040] From the viewpoint of foaming and foam quality, the anionic surfactant preferably contains a sulfonic acid group, and more preferably an alkyl sulfate or an α-olefin sulfonate. When the oral composition is a dentifrice, the content of the anionic surfactant is preferably 0.1 to 2.5% by mass, more preferably 0.6 to 2.5% by mass, and even more preferably 1 to 2.5% by mass of the entire composition. When the oral composition is a mouthwash, the content of the anionic surfactant is preferably 0 to 1.0% by mass, more preferably 0 to 0.3% by mass of the entire composition.

[0041] Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 5 to 30 moles. The average number of moles of ethylene oxide added in the polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferred.

[0042] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylaminoacetate betaine (e.g., lauryl dimethylaminoacetate betaine) and fatty acid amidopropyl dimethylaminoacetate betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylaminoacetate betaine.

[0043] The content of the surfactant is preferably 0.1 to 5 mass %, more preferably 0.5 to 3 mass %, based on the total mass of the oral cavity composition.

[0044] -Sweetener- The oral composition of the present embodiment may contain any suitable sweetener known in the art in any suitable content. By including a sweetener in the oral composition, the feeling of use can be further improved.

[0045] Examples of sweeteners include saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartyl phenylalanine methyl ester, etc. As the sweetener, the above-exemplified sweeteners may be used alone or in combination of two or more.

[0046] -Fragrance- The oral composition of the present embodiment may contain any suitable flavoring agent known in the art in any suitable amount. By including a flavoring agent in the oral composition, the feeling of use can be further improved.

[0047] Examples of the fragrance include natural essential oils such as peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, pimento oil, cassia leaf oil, perilla oil, and wintergreen oil; menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, sitho Fragrance components contained in the above-mentioned natural essential oils, such as arhal, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyl linalool, and vanillin; fragrance components, such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-l-menthyl carbonate; and various blended flavors, such as mint, fruit, and herb flavors, which are made by combining several fragrance components and natural essential oils. In addition, the fragrance may be a cooling agent other than the component (B), such as N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthane carboxamide, 3-l-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamide)ethyl acetate, and 2-isopropyl-N,2,3-trimethylbutyramide. The fragrance may be used alone or in combination of two or more of the above-listed fragrances.

[0048] -Medicinal ingredients- Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque Enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; anti-inflammatory agents such as ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhetinic acid stearyl, allantoin chlorohydroxyaluminum, azulene, and dihydrocholesterol. Examples of the medicinal ingredients include: anti-calculus agents; metal salts such as zinc salts, copper salts, and tin salts; condensed phosphates, ethanehydroxydiphosphonates, and other anti-calculus agents; blood flow promoters such as vitamin E (e.g., tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salts), lysozyme chloride, and sodium chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; anti-calculus agents, amino acids such as alanine, glycine, and proline, callopeptides, and polyvinylpyrrolidone. The medicinal ingredients may be used alone or in combination of two or more. The content of the medicinal ingredients can be appropriately set to an effective amount according to the usual method.

[0049] -Oily ingredients- Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

[0050] -Preservatives- The oral composition of the present embodiment may contain any suitable preservative known in the art in any suitable amount. By including a preservative in the oral composition, the oral composition can ensure the preservative effect.

[0051] Examples of preservatives that may be contained in the oral cavity composition include paraoxybenzoic acid esters (e.g., methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate, etc. The preservatives may be used alone or in combination of two or more.

[0052] -Wetting agent- The oral composition of the present embodiment may contain any suitable content of a conventionally known humectant. By including any humectant in the oral composition, the feeling of use can be further improved.

[0053] As the humectant, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, xylitol, and reduced starch saccharification products; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycol include polyethylene glycols having an average molecular weight of 150 to 6000, and preferably polyethylene glycols having an average molecular weight of 190 to 630. Specific examples include PEG200, PEG300, PEG400, and PEG600. The content of the humectant is usually 40% by mass or less, and preferably 1 to 30% by mass, based on the entire oral composition (100% by mass). The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2006.

[0054] -Binding agent- The oral composition of the present embodiment may contain any suitable conventionally known binder in any suitable content. By including any suitable binder in the oral composition, the viscosity can be optimized, and the shape retention and usability can be further improved.

[0055] The optional binder that may be contained in the oral composition may include any suitable organic binder known in the art, such as polysaccharides, cellulose-based binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationic cellulose, etc.), other polysaccharide-based thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as thickening silica and aluminum silicate may also be blended.

[0056] The content of the optional organic binder is preferably 0 to 3 mass %, more preferably 0.1 to 2 mass %, based on the total oral cavity composition, and the content of the optional inorganic binder is preferably 0 to 10 mass %, more preferably 1 to 8 mass %, based on the total oral cavity composition.

[0057] -pH adjuster- The oral composition of the present embodiment may contain any suitable content of a conventionally known pH adjuster. By including a pH adjuster in the oral composition, the pH stability of the oral composition can be ensured.

[0058] Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or salts thereof (e.g., sodium citrate), inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or salts thereof (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

[0059] The content of the pH adjuster can usually be an amount such that the pH of the oral composition after addition is 5 to 9, preferably 6 to 8.5.

[0060] In this specification, the pH value generally refers to the value 3 minutes after the start of measurement at 25° C. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0061] -Coloring agent- The oral composition of the present embodiment may contain any suitable colorant that is conventionally known in any suitable amount.

[0062] Examples of colorants that the oral composition may contain include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and tamarind colorant, legal colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, riboflavin, sodium copper chlorophyte, and titanium dioxide. When the oral composition contains a colorant, the content of the colorant is preferably 0.00001 to 3% by mass based on the total amount of the oral composition.

[0063] -Other optional ingredients- The oral composition of the present embodiment may contain any suitable amount of optional components other than those described above.

[0064] Examples of other optional components that may be contained in the oral composition include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not impair the effects of the present invention.

[0065] [Formulation and use of oral composition] The oral composition of the present invention can be made into any suitable dosage form known in the art by any suitable method according to conventional methods.The dosage form can be, for example, liquid (solution, emulsion, suspension, syrup, etc.), semi-solid (gel, cream, paste, etc.), solid (tablet, particulate agent, capsule, film agent, kneaded material, molten solid, waxy solid, elastic solid, soft capsule, etc.).The dosage form of the oral composition is preferably liquid or semi-solid.

[0066] The oral composition of the present invention can be widely used in oral applications. Examples of applications of the composition in a solid dosage form include lozenges, gummies, chewing gum, and dentifrices. Examples of applications of the composition in a semisolid dosage form include toothpaste and gel dentifrices. Examples of applications of the composition in a liquid dosage form include mouthwash, liquid dentifrices, and mouth fresheners (sprays, etc.). The oral composition of the present invention is preferably used as a dentifrices (toothpaste, gel dentifrices) or mouthwash, since it can reduce the sticky feeling in the oral cavity after use and the bitterness derived from plant extracts after use, and can provide a good feeling of freshness in the oral cavity after use.

[0067] [Method of manufacturing oral composition] The method for producing the oral composition of the present invention is not particularly limited. The oral composition can be produced by a conventional method according to the selected formulation. For example, when the oral composition is to be used as a toothpaste, the method includes first preparing the components that dissolve in the solvent, then mixing the other insoluble components, and, if necessary, further degassing the composition by, for example, reducing pressure.

[0068] The toothpaste thus obtained can be packed into a laminate tube, or the mouthwash can be packed into a predetermined container (such as a bottle) to produce a product.

[0069] The shape and material of the container in which the oral composition of the present invention can be stored are not particularly limited. Any suitable conventional container used for oral compositions can be used. Examples of the container include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon. EXAMPLES

[0070] The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to the following examples. The numerical values ​​in the following tables represent mass % unless otherwise specified.

[0071] [Components used in the Examples and Comparative Examples] First, the components used in the examples and comparative examples will be described. -(A) Component- (A1) Rosemary extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Rosemary Extract-J, extraction solvent: 50% ethanol / 50% water, part used: leaves) Manufacturer: (A2) Scutellaria root extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Scutellaria root extract-J, extraction solvent: 50% ethanol / 50% water, part used: root) (A3) Carrot extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Carrot extract, extraction solvent: 50% ethanol / 50% water, part used: root) (A4) Sage extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Salvia extract, extraction solvent: 50% ethanol / 50% water, part used: leaves) (A5) Licorice extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Licorice extract, extraction solvent: 50% ethanol / 50% water, part used: root) (A6) Sword bean extract (manufactured by Yamada Yaken Co., Ltd., product name: AOF Sword bean extract-HBG, extraction solvent: 50% 1,3-butylene glycol / 50% water, part used: seeds) (A7) Phellodendron Amurense Extract (manufactured by Ogi Pharmaceutical Co., Ltd., product name: Phellodendron Amurense Extract, extraction solvent: water, part used: bark excluding periderm) (A8): Angelica acutiloba extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Angelica acutiloba extract-JC, extraction solvent: 50% ethanol / 50% water, part used: root) (A9) Olive leaf extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: Olive Extract-BG, extraction solvent: 50% butylene glycol / 50% water, part used: leaves) (A10) Persimmon tannin extract (manufactured by Release Science Industry Co., Ltd., product name: Pansil BA-200E-1, extraction solvent: water, part used: fruit) (A11) Tea extract (manufactured by Maruzen Pharmaceutical Co., Ltd., product name: "Waism", extraction solvent: 80% ethanol / 20% water, part used: leaves)

[0072] -(B) Component- (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide (manufactured by Takasago International Corporation, trade name: Coolact (registered trademark) 370)

[0073] -(C) component- (C) Abrasive silica (manufactured by Solvay, trade name: Tixosil (registered trademark) 73)

[0074] Ingredients other than components (A) to (C) N-Ethyl-p-menthane-3-carboxamide: Symrise Japan Sorbitol solution (70%): Mitsubishi Corporation Life Sciences Co., Ltd. Propylene glycol: ADEKA Viscosifying silica: manufactured by DSL Japan Co., Ltd., product name: Carplex (registered trademark) #67 Xanthan gum: DSP Gokyo Food & Chemical Co., Ltd. Sodium lauryl sulfate: BASF Sodium fluoride: Stella Chemifa Co., Ltd. Sodium saccharin: manufactured by Aisan Chemical Industry Co., Ltd. Fragrance A~P The above ingredients were made from raw materials that conformed to the 2006 Standards for Quasi-Drug Raw Materials.

[0075] The composition of the fragrance A used in each of the Examples and Formulation Examples, and the compositions of the fragrances B to P used in the Formulation Examples are shown in Tables 1 to 10 below.

[0076] [Table 1]

[0077] [Table 2]

[0078] The compositions of flavors 1 to 7 and solvents used in the above fragrances A to P are shown in Tables 3 to 10 below.

[0079] [Table 3]

[0080] [Table 4]

[0081] [Table 5]

[0082] [Table 6]

[0083] [Table 7]

[0084] [Table 8]

[0085] [Table 9]

[0086] [Table 10]

[0087] Examples 1 to 19 and Comparative Examples 1 to 16 Using the above ingredients as raw materials, oral compositions having the formulations shown in Tables 11 to 14 were prepared according to the preparation methods described below. The amounts of component (A) in Tables 11 to 14 are the pure amounts of extract excluding the extraction solvent.

[0088] [Method of preparing oral composition] The raw materials shown in Tables 11 to 14 were mixed in a conventional manner to obtain oral compositions, which were dentifrices (toothpastes) or mouthwashes. The oral compositions obtained were then placed in any suitable conventional oral preparation container (toothpaste: laminated tube, mouthwash: bottle).

[0089] The obtained toothpastes (Examples 1 to 18 and Comparative Examples 1 to 16) or mouthwashes (Example 19) were evaluated according to the following procedures. The evaluation results are shown in Tables 11 to 14 below.

[0090] [Evaluation method] 1 g of the oral composition according to the Examples and Comparative Examples was placed on the bristles of a toothbrush (Clinica Advantage Toothbrush, 4-row compact normal, manufactured by Lion Corporation), brushed for 3 minutes in the usual manner, and then rinsed the oral cavity once with 10 mL of water to use the oral composition. When the oral composition was a mouthwash, 10 mL of the mouthwash was placed in the oral cavity, rinsed for 30 seconds, and then expelled.

[0091] The four subjects scored the stickiness in the oral cavity after use, the bitterness (aftertaste) derived from the plant extract after use, and the refreshing feeling in the oral cavity 60 minutes after use, using the following rating scale to calculate the average score, and the average score obtained was evaluated on a three-level scale of excellent (◎), good (○), and poor (×) according to the following rating scale. The results are shown in Tables 11 to 14 below.

[0092] -Evaluation of stickiness in the mouth after use- (Scoring criteria) 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive (Evaluation Criteria) ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0093] -Evaluation of bitterness derived from plant extracts after use- (Scoring criteria) 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive (Evaluation Criteria) ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0094] -Evaluation of oral cavity freshness 60 minutes after use- (Scoring criteria) 5: Very sensitive 4: Feel 3: Somewhat 2: Not much 1: No feeling at all (Evaluation Criteria) ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0095] In addition, when the oral cavity compositions of the examples were evaluated for "oral irritation after use" in the same manner as the above evaluation based on the following rating scale, it was not evaluated that a strong irritation was felt in the oral cavity. The results are shown in Tables 11 to 12 below.

[0096] -Evaluation of oral irritation after use- Scoring criteria 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0097] [Table 11]

[0098] [Table 12]

[0099] [Table 13]

[0100] [Table 14]

[0101] Formulation examples of the oral composition of this embodiment are shown below. Formulation example 1: Dentifrice (A1) Rosemary extract 0.0002% by mass (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide 0.001% by mass (C) Abrasive silica 15% by mass Sorbitol solution (70%) 30% by weight Propylene glycol 4% by weight Viscosifying silica 4% by mass Xanthan gum 1.5% by mass Sodium lauryl sulfate 1.5% by mass Sodium fluoride 0.2% by mass Sodium saccharin 0.2% by mass Fragrance (A~P) 1% by mass water remainder Total 100% by mass (A) / (B)=0.2

[0102] Prescription example 2: Mouthwash (A1): Rosemary extract 0.0002% by mass (B): N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide 0.005% by mass Ethanol 2.0% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Cetylpyridinium chloride 0.05% by mass Methyl paraoxybenzoate 0.25% by mass Fragrance (A~P) 1% by mass water remainder Total 100% by mass (A) / (B)=0.04

[0103] Prescription example 3: Mouthwash (A1): Rosemary extract 0.0002% by mass (B): N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide 0.005% by mass Propylene glycol 3.0% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Cetylpyridinium chloride 0.05% by mass Methyl paraoxybenzoate 0.25% by mass Fragrance (A~P) 1% by mass water remainder Total 100% by mass (A) / (B)=0.04

[0104] As is clear from the above, in Comparative Examples 1 to 16, which contained only one of the components (A) and (B), and also the component (C), the evaluations of the stickiness in the oral cavity after use, the bitterness derived from the plant extract after use, and the refreshing feeling in the oral cavity 60 minutes after use were all extremely low, whereas in Examples 1 to 19, which may contain both the components (A) and (B), and even the component (C), the evaluations of the stickiness in the oral cavity after use, the bitterness derived from the plant extract after use, and the refreshing feeling in the oral cavity 60 minutes after use were all good.

Claims

1. (A) a plant extract; (B) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide It contains (A) A composition for the oral cavity, wherein the plant extract is an extract of one or more plants selected from the group consisting of rosemary, Scutellaria baicalensis, carrot, licorice, Angelica acutiloba, sword bean, olive, and Phellodendron amplexicaule.

2. (A) containing a plant extract in an amount of 0.00001 to 0.05% by mass in terms of the pure extract content; The oral composition according to claim 1, further comprising (B) 0.00001 to 0.1 mass% of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.

3. 3. The oral composition according to claim 1 or 2, wherein the mass ratio of the content of the plant extract (A) (pure extract content) to the content of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide (B) is 0.02 to 100.

4. The oral composition according to any one of claims 1 to 3, which is a dentifrice or a mouthwash.

5. The oral composition according to claim 4, which is a dentifrice and further contains 8 to 70 mass% of an abrasive (C).

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