A system, method, and computer program product for selectively modifying an X-ray image of a tissue sample.

Abstract

X-ray images generated by the biopsy tissue handling device are selectively modified to emphasize areas of interest and to de-emphasize or eliminate image areas that are distracting, impair visual attention, and / or contribute to eye fatigue. An image processor executes an image mask based on the geometric configuration of a portion of a sample tray including a storage compartment with a tissue sample. The compartment mask is executed on a portion of the X-ray image depicting the storage compartment containing the tissue sample. The compartment mask boundary substantially corresponds to the contour of the compartment. A partial structure mask is executed on a portion of the X-ray image depicting each wall of the sample tray and storage compartment. The partial structure mask boundary extends along each length and partially through each wall of the sample tray.

Description

[Technical field]

[0001] The disclosed invention relates generally to imaging of biopsy tissue samples, and more specifically to systems, methods, and computer program products for correcting and enhancing X-ray images of tissue samples, which may be performed in real time during a biopsy procedure. [Background technology]

[0002] A biopsy is a well-known medical procedure that involves the removal of tissue from a living body to examine the tissue for diagnostic studies, such as determining the presence, cause, or extent of disease. For example, a biopsy of human breast tissue may be performed to diagnose breast cancer or other diseases. The current standard of care is a percutaneous biopsy, which is performed by inserting a biopsy device having a needle and a cutting device through a small incision and advancing the needle and cutting device to the site of the tissue of interest. The cutting device then cuts a sample of the tissue, captures the tissue sample, and removes the tissue sample through the small incision. Percutaneous biopsy devices use various means to remove the tissue sample, such as simply removing the device through the incision with the captured tissue sample, or transporting the tissue sample out through the device (the tissue sample may be removed or drawn through a tube into a container). One advantage of removing a tissue sample from a biopsy device is that multiple samples may be taken without the need to remove the biopsy device from the patient.

[0003] Tissue samples are typically imaged for review using an X-ray imaging system. For example, tissue samples may be placed in an X-ray sample tray or container and then placed in a sample imaging device for taking images of the tissue. Automated biopsy and imaging systems for performing biopsies and imaging tissue samples have also been disclosed. An example of a tissue biopsy and handling device is described in U.S. Pat. No. 9,492,130, the contents of which are incorporated herein by reference as if fully set forth. In particular, U.S. Pat. No. 9,492,130 discloses an integrated biopsy analysis system having a biopsy resection tool, a tissue sample transport mechanism for automatically transporting the resected tissue sample from the biopsy resection tool to an analysis / imaging unit, and an analysis / imaging system for automatically analyzing the tissue sample image acquired by the X-ray imaging device. The system resects the tissue sample and transports and places the resected tissue sample in a sample holder having multiple tissue receiving slots for placing multiple different tissue samples. The imaging unit is configured to obtain images of the tissue samples in the tissue holder, such as by obtaining an individual image of each tissue sample in its respective tissue receiving slot.

[0004] However, known biopsy and imaging systems have several drawbacks and can be improved. For example, while the X-ray images generated by known biopsy and imaging systems can be informative and useful, certain content of the X-ray images can be distracting and cause eye fatigue due to the imaging of image portions with associated sample holder structures and different brightness. Some image portions can be substantially brighter than others (e.g., metal objects), so that the user's attention can be drawn to these areas initially and during the course of the sample review. Such bright spots would otherwise be in the user's field of view when reviewing the X-ray image. These distractions and interruptions resulting from the imaging of non-sample objects can be inconvenient, time-consuming, and can impair the viewer's analysis and stamina, and these drawbacks are exacerbated in that the user is required to engage in longer review sessions and review a larger number of sample images. Such drawbacks disrupt the review workflow as a result of the need to spend extra time on lower quality images.

[0005] Other biopsy and imaging systems have been designed to improve fluid control during X-ray image acquisition, as fluid in the imaging field can result in reduced image quality. For example, when acquiring images using an X-ray imaging device, fluid may partially or completely cover or obscure the tissue sample and / or adhere to the top of or partially or completely cover the tissue sample. Interfering fluids may have attenuation properties similar to the tissue sample being imaged, obscuring parts of the sample. The imaged tissue sample may therefore appear similar to cancerous tissue or tissue with characteristics indicative of cancer, such as a mass, tumor, or calcification. Interfering fluids may also appear as a shadow blocking an image portion of interest.

[0006] To address these shortcomings, filter tray assemblies have been designed with structures for managing fluid within the imaging field during x-ray imaging of tissue samples. Fluid management can involve using different types of fluid control structures to prevent fluid from entering the imaging field and / or to remove fluid that does enter the imaging field.

[0007] However, these additional fluid control structures, which may be made from plastic or other radiopaque materials, will also be imaged with the sample and will appear in the resulting x-ray image. Thus, although these additional structures may improve fluid management, they may also contribute to various x-ray image shortcomings described above due to the additional fluid management structures being imaged. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] U.S. Patent No. 9,492,130 Summary of the Invention [Means for solving the problem]

[0009] Embodiments of the tissue biopsy and handling systems, methods, and imaging algorithms described herein provide improved x-ray imaging by selectively modifying x-ray images, which can be done in real-time or coincident with tissue extraction and processing.

[0010] Embodiments of the tissue biopsy and handling systems, methods, and imaging algorithms described herein provide improved x-ray imaging by selectively modifying an x-ray image of a sample tray containing a sample and having additional structures to improve fluid management structures during x-ray imaging.

[0011] Embodiments of the tissue biopsy and handling systems, methods, and imaging algorithms also provide improved tissue sample x-ray images that are cleaner and more focused to emphasize image portions of interest while de-emphasizing or eliminating distracting image portions to maintain the viewer's attention.

[0012] Embodiments of the tissue biopsy and handling systems, methods, and imaging algorithms also provide improved tissue sample x-ray images that are gentler on the viewer's eyes and therefore improve viewer eye fatigue as compared to raw x-ray images such as those generated by x-ray imaging devices.

[0013] Embodiments of the tissue biopsy handling system, method, and imaging algorithm also provide improved imaging of samples in various types and configurations of sample trays. Sample trays can be made from plastic and other radiopaque materials and can contain different radiopaque objects such as magnets and printed indicia that act as compartment references or "zero" position markers.

[0014] The embodiments also provide sample imaging that accommodates manufacturing imperfections and collimator offsets during imaging.

[0015] The embodiments provide improved imaging of samples by utilizing a partial structure mask that is implemented such that outer portions of the sample tray walls, such as partition walls, are de-emphasized or eliminated while inner portions of the walls that define the tissue storage compartments are maintained or enhanced. In other words, the boundary of the partial structure mask does not encompass the entire width or thickness of the sample tray wall, and this partial thickness boundary may extend over the length or perimeter of the wall. In this way, the partial structure mask captures a portion of the respective wall (the inner wall section that defines or is adjacent to the tissue storage compartment) and the remaining portion of the storage compartment that was not encompassed by or exceeds the boundary of the imaging mask with respect to the interior compartment. For example, the partial structure mask may include the inner 25%-50% of the wall, whether linear or arcuate or other shape in shape. The embodiments thus show the selected appropriate wall structure, more specifically, the portion of the sample tray wall closest to or adjacent the storage compartment or sample, while de-emphasizing or eliminating the outer wall structure that may be visually distracting and not necessary.

[0016] According to one embodiment, a computer-implemented method executed by a biopsy tissue handling device includes obtaining an X-ray image of a tissue sample in a storage compartment of a sample tray by an X-ray imaging system of the biopsy tissue handling device. The method further includes generating a modified X-ray image by an image processor in communication with the X-ray imaging system executing an imaging algorithm. The modified X-ray image is generated by an image processor executing an imaging algorithm including executing a plurality of image masks based at least in part on a geometric configuration of at least a portion of the sample tray including the storage compartment with the tissue sample. A compartment mask is executed on a portion of the X-ray image depicting the storage compartment with the cut tissue sample. The compartment mask boundary substantially corresponds to a contour of the sample tray wall defined by the sample compartment, which may be linear or curved / arcuate. A partial structure mask is executed on a portion of the X-ray image depicting the respective walls of the sample tray and the portion of the storage compartment. The boundary of the partial structure mask extends partially through the respective walls of the sample tray along their respective lengths and captures a portion of the wall thickness and a portion of the storage compartment not encompassed by the compartment mask.

[0017] Thus, the partial structure mask boundary extends partially into the sample tray wall (e.g., up to the first quarter, first third, or first half of the sample tray wall) along the length or perimeter of the sample tray wall. In other words, in such an embodiment, the boundary of the partial structure mask does not encompass the full width or thickness of the sample tray wall. In this way, the partial structure mask captures the respective inner sections or portions of each wall of the sample tray, while also capturing the remaining portions of the storage compartment that are not included within and beyond the compartment mask boundary, thereby showing the appropriate wall structure selected for the compartment and sample, while de-emphasizing or eliminating the outer wall structure that may be unnoticeable and visually distracting.

[0018] In another embodiment, a biopsy tissue handling device includes a sample tray, a tube, an x-ray imaging system, and a display. The sample tray defines one or more storage compartments or chambers for holding one or more tissue samples. The tube defines a vacuum lumen in communication with the storage compartment such that the tube can receive the cut tissue sample and deliver the cut tissue sample along with a fluid into the storage compartment through the vacuum lumen. The x-ray imaging system is positioned or disposed relative to the tissue storage compartment to obtain x-ray images of the cut tissue sample in the storage compartment of the sample tray. An image processor in communication with the x-ray imaging system is programmed or configured to execute an imaging algorithm that modifies the x-ray image by executing a plurality of image masks based at least in part on a geometric configuration of at least a portion of the sample tray including the storage compartment with the tissue sample. The compartment masks are executed on a portion of the x-ray image depicting the storage compartment with the cut tissue sample. The compartment mask boundaries substantially correspond to a contour of the sample tray wall defined by the sample compartment. A partial structure mask is also performed on a portion of the X-ray image depicting the respective walls of the sample tray and storage compartment. The boundary of the partial structure mask extends partially through the respective walls of the sample tray along their respective lengths to capture the portion of the wall thickness and the portion of the storage compartment not encompassed by the compartment mask. Other system embodiments may include one or more of a sample tray, a tube, an X-ray imaging system, and a display, and combinations thereof.

[0019] In a further embodiment, a non-transitory computer readable medium tangibly embodying one or more sequences of instructions that may be executed by one or more processors contained within one or more computing systems of a biopsy tissue handling device causes the one or more computing systems to obtain and modify x-ray images by executing the computer-implemented methods and imaging algorithms of the embodiments.

[0020] In one or more embodiments or options, the compartment mask is an internal compartment mask that excludes the walls of the storage compartment, the imaging portion of the collimator of the X-ray imaging device, and the magnet. The magnet can serve as a "zero" position marker for the tissue storage compartment while the sample tray is rotated about an axis. The compartment mask enhances or highlights at least one of the brightness and contrast of pixels of the X-ray image that depict the tissue sample within the compartment. The compartment mask can encompass the entire sample or a portion of the sample, and the remaining portion of the sample can be encompassed by a partial structure mask.

[0021] In one or more embodiments or options, the partial structure mask is implemented to mask, darken, or reduce at least one of the brightness and contrast of pixels in the X-ray image depicting an outer portion of each plastic wall of the sample tray outside a boundary of the partial structure mask, the partial structure mask boundary being determined or based on a predetermined point (e.g., midpoint) within the wall or a predetermined distance from a boundary of the compartment mask.

[0022] In one or more embodiments or options, the boundary of the partial structure mask is substantially the same shape as and encompasses the boundary of the compartment mask, which in one embodiment includes a pair of linear boundary segments and a pair of curved / arcuate boundary segments extending between the linear boundary segments. Other compartment mask and partial structure mask configurations may also be utilized.

[0023] In one or more embodiments or options, the image processor performs a foreign object mask on a portion of the x-ray image depicting an object, such as a magnet or printed indicia, embedded in, affixed to, or applied to the sample tray. For example, a metal magnet may be embedded in a plastic wall section of the sample tray and serve as a reference or "zero" position compartment marker and may be used to engage another magnet to rotate the sample tray. For these types of objects (e.g., metal objects), the mask may mask out, darken, or reduce at least one of the brightness and contrast of pixels in the x-ray image depicting the radiopaque magnet, which substantially corresponds to the outer periphery of the magnet and initially appears as a bright white spot in the original x-ray image. Thus, the embodiment reduces or eliminates the tendency of the magnet to stand out in the x-ray image and attract the viewer's attention. As another example, the object may be a printed indicia, such as a number or letter printed in tungsten ink, associated with or identifying a tissue compartment. For these types of objects, the boundary of the foreign object mask (e.g., a square or rectangle surrounding the indicia) defines the area that contains the indicia and should be included in the modified image. Thus, depending on the type of object identified or indicated by the user, the object can be de-emphasized (e.g., for a metal magnet), or excluded, or selected for inclusion in the modified x-ray image.

[0024] In one or more embodiments or options, the boundaries of the compartment mask include a first linear boundary section, a second linear boundary section, a first arcuate boundary section, a second arcuate boundary section, and a third arcuate boundary section. The first arcuate boundary section extends between the first linear boundary section and the second linear boundary section, the second arcuate boundary section extends between the first linear boundary section and the third arcuate boundary section, and the third boundary section extends between the second arcuate boundary section and the second linear boundary section. In this compartment mask configuration, for example, the radius of curvature of the third arcuate section of the compartment mask adjacent the imaging portion of the magnet is smaller than the respective radii of curvature of the first and second arcuate boundaries of each of the sample and tray structure masks. The partial structure mask may be the same shape as the compartment mask, or in other embodiments, part of the boundary of the tray structure mask may extend through the area defined by the boundary of the foreign object mask, e.g., the imaging portion of the magnet, such that the boundaries of the compartment and partial structure masks may be different shapes.

[0025] In one or more embodiments or options, the image mask performed by the image processor is a predetermined region of interest mask that is operable to first crop the x-ray image, for example, to exclude portions of the x-ray image that depict a metal collimator of the x-ray imaging system. In one or more embodiments or options, the predetermined region of interest mask is a first image mask prior to the execution of compartment and partial structure masks that are performed on the raw x-ray image.

[0026] In a single or multiple embodiments or options, at least a portion of the geometric configuration of the sample tray and / or the orientation of the image mask to be performed is based at least in part on the center, e.g., center of mass, of the printed indicia associated with the storage compartment. If required, the X-ray image can be rotated to align the center of the printed indicia with a predetermined axis (e.g., horizontal axis) to align or align the X-ray image with the geometric configuration of the sample tray, and / or the image mask initially configured for the properly aligned image can be rotated. The mask orientation and associated structural or geometric sample tray configuration can also be rotated for these purposes. Thus, the embodiments can automatically compensate and adapt to the rotation or mechanical inconsistencies of the biopsy tissue handling device, and thus the geometric configuration can be utilized to determine the corresponding division in the X-ray image when performing the image mask.

[0027] In one or more embodiments or options, the image processor determines offset values ​​of a collimator of the X-ray imaging device, e.g., horizontal offset values ​​relative to the sides or left and right edges of the tissue compartment being imaged, for leveling or aligning the X-ray image or a portion thereof and / or for adjusting where an image mask is performed so that the image mask is applied to determine a corresponding section in the X-ray image.

[0028] In one or more embodiments or options, the biopsy tissue handling device deposits the cut tissue sample into the storage compartment through a vacuum lumen that communicates with the storage compartment.

[0029] In one or more embodiments or alternatives, the generated or raw x-ray image is modified by altering pixel values ​​according to a number of masks and incorporating the modified x-ray image pixel data into a Digital Imaging and Communications in Medicine (DICOM) object. Other data formats may also be utilized.

[0030] In one or more embodiments or options, an image mask is implemented to modify the x-ray image in real-time during processing of the sectioned tissue sample.

[0031] In one or more embodiments or options, the brightness values ​​of pixels of the X-ray image depicting the tissue sample are selectively modified to adapt the respective brightness levels to the respective different thicknesses of the imaged tissue sample. For example, the portions of the X-ray image depicting the thinner portions of the sample as opposed to the thicker portions of the sample can be identified, and pixel adjustments can then be made based on the different sample thicknesses, e.g., the brightness values ​​of pixels for the thinner and thicker sample portions are enhanced with their respective brightness and contrast, and thus the sample edges of both the thinner and thicker sample portions can be depicted while the thicker sample portions are not too bright. Thus, pixel values ​​can be selectively adapted across the sample thickness. [Brief description of the drawings]

[0032] The foregoing and other aspects of the embodiments of the invention disclosed herein will now be described in further detail with reference to the accompanying drawings, in which like reference numerals refer to like elements and descriptions of like elements, whenever relevant, are applicable with respect to all described embodiments.

[0033] [Figure 1] FIG. 1 is a block diagram of a tissue biopsy and handling system constructed in accordance with one embodiment for x-ray imaging of a tissue sample and correction of the x-ray image of the tissue sample.

[0034] [Diagram 2] FIG. 2 is a flow diagram of a method for correcting an x-ray image of a tissue sample according to one embodiment.

[0035] [Diagram 3] FIG. 3 is a flow diagram of a method for correcting an x-ray image of a tissue sample according to one embodiment.

[0036] [Figure 4A] 4A-B depict a tissue biopsy and handling system operable to implement an embodiment and perform a breast biopsy procedure and real-time imaging of a breast tissue sample during the biopsy procedure, with FIG. 4A illustrating the imaging cabinet in an open position and FIG. 4B illustrating the imaging cabinet in a closed position. [Figure 4B] 4A-B depict a tissue biopsy and handling system operable to implement an embodiment and perform a breast biopsy procedure and real-time imaging of a breast tissue sample during the biopsy procedure, with FIG. 4A illustrating the imaging cabinet in an open position and FIG. 4B illustrating the imaging cabinet in a closed position.

[0037] [Diagram 5] FIG. 5 depicts an embodiment of an imaging cabinet of a tissue biopsy and handling system constructed in accordance with one embodiment.

[0038] [Figure 6] FIG. 6 depicts an example of a tissue biopsy and handling system that may be utilized to further dissect the tissue sample and tubing assembly through which fluids such as saline and blood may flow during a biopsy procedure.

[0039] [Figure 7-1] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-2]Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-3] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-4] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-5] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-6] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs. [Figure 7-7] Figures 7A-M depict in further detail an example of a tissue filter assembly of a tissue biopsy and handling system that includes a tissue storage compartment in which tissue samples and fluids are deposited during a biopsy procedure, Figures 7A-D depict one exemplary tissue filter assembly with a rotatable sample tray, and Figures 7E-M depict a tissue filter assembly that also includes additional fluid management structures including fluid channels and flow combs.

[0040] [Figure 8-1] FIG. 8 is a flow diagram of a method for correcting an x-ray image of a tissue sample according to one embodiment. [Figure 8-2] FIG. 8 is a flow diagram of a method for correcting an x-ray image of a tissue sample according to one embodiment.

[0041] [Figure 9] FIG. 9 illustrates an example of how the structural or geometric configuration of at least a portion of the sample tray is applied to the X-ray image.

[0042] [Figure 10] 10A-B are X-ray images demonstrating the visual enhancement achieved by an embodiment, where FIG. 10A is a raw X-ray image of a portion of a sample tray including an imaged magnet and FIG. 10B is a modified X-ray image generated in accordance with an embodiment.

[0043] [Figure 11] 11A-B are X-ray images demonstrating the visual enhancement achieved by an embodiment, where FIG. 11A is a raw X-ray image of a portion of a sample tray that does not include a magnet and FIG. 11B is a modified X-ray image generated in accordance with an embodiment. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0044] The embodiments provide tissue biopsy and handling systems, methods, and imaging algorithms that selectively modify the x-ray images of tissue samples by implementing an image mask and structural or geometric configuration of at least a portion of the sample tray imaged and depicted within the x-ray image. The modified x-ray images generated according to the embodiments are cleaner and more focused than traditional or raw x-ray images, which can be cluttered with extraneous bright areas that can be very distracting to the viewer and contribute to viewer fatigue and reduced review throughput. The modified x-ray images generated according to the embodiments emphasize or maintain appropriate image portions while de-emphasizing or removing image portions of extraneous or highly attenuating objects (such as magnets and various extraneous sample tray structures). The embodiments thus have added structure to manage the control of fluids (blood, saline, anesthetic agents, biological fluids, etc.) in and out of the imaging field, and are also particularly suited for x-ray imaging of participating sample trays that are imaged along with the sample. The embodiments are adaptable to modify x-ray images of various types of sample tray structures. Additionally, given the manner in which the embodiments are implemented, the embodiments can be adapted to mechanical and imaging variations of different imaging systems and components.

[0045] The embodiments advantageously perform to generate improved x-ray images, which may be after tissue processing or in real time during tissue processing. For example, during processing, a tissue sample is cut from a patient, aspirated through a vacuum tube along with a transport fluid and / or bodily fluid, such as saline, blood, or a combination thereof, and deposited with the fluid in a storage compartment of a sample tray. An x-ray image of the cut tissue sample is obtained, and the embodiments are performed to selectively modify the generated x-ray image. The resulting modified x-ray image, rather than the generated x-ray image, can then be presented to a radiologist or other user of the tissue biopsy and handling system through a display in real time during the procedure. The modified x-ray image and the generated x-ray image can also be presented together for additional review and comparison. Image acquisition and embodiment execution can be performed while the patient remains on the stereotactic table, after the cut tissue sample is aspirated through a vacuum tube and deposited in the sample tray, before the tissue sample is removed from the sample tray, and before the tissue sample is removed from the housing of the tissue biopsy and handling system.

[0046] 1, a schematic diagram of a tissue biopsy and handling system 100 (generally, tissue biopsy system 100) constructed in accordance with one embodiment is shown. The schematic diagram of FIG. 1 illustrates certain features of tissue biopsy system 100, which may include components and features of a tissue biopsy system such as those disclosed in U.S. Patent No. 9,492,130 B2, the contents of which are incorporated herein by reference as if fully set forth.

[0047] The exemplary tissue biopsy system 100 includes a tissue filter or tissue retainer assembly 110 (generally, tissue filter assembly 110). The tissue filter assembly 110 is attached to and connected between a biopsy resection tool 120 and a suction canister 130. The biopsy resection tool 120 and the tissue filter assembly 110 are in fluid communication with each other via an inlet line 122. The tissue filter assembly 110 and the suction canister 130 are in fluid communication with each other through an exhaust suction line 132. A vacuum source (not shown in FIG. 1 ) is in communication with the exhaust suction line 132 and / or the suction canister 130 such that activation of the vacuum source results in the suction of a tissue sample 123 excised by the biopsy resection tool 120 and one or more bodily fluids or added fluids 124 through the inlet line 122 and into a tissue storage compartment of a sample tray of the tissue filter assembly 110.

[0048] The tissue biopsy system 100 includes an imaging unit 140 that is positioned relative to the tissue filter assembly 110 such that the excised tissue sample 123 and fluid 124 deposited within the tissue filter assembly 110 are positioned within the field of view of the imaging unit 140, which includes an x-ray imaging device 141 that generates an x-ray image 150. The x-ray imaging device 141 utilizes photons within an energy range of about 10 keV to about 100 keV and a wavelength of about 0.01 nm to about 10 nm. The x-ray imaging device 141 is in communication with an image processor 160, which receives an input including data for the generated (or x-ray) image 150.

[0049] Image processor 160 according to an embodiment generates a modified x-ray image 150m ("m" stands for "modified") by executing an imaging algorithm that utilizes image mask 170 and a structural or geometric configuration 172 of at least a portion of the sample tray of tissue filter assembly 110 imaged and depicted in x-ray image 150. Image processor 160 also communicates with a display 180 of tissue biopsy system 100 for presenting modified x-ray image 150m to a user or operator of tissue biopsy system 100.

[0050] 2, generally, in one embodiment of a computer-implemented method 200 performed by the tissue biopsy system 100 illustrated in FIG. 1, after the tissue sample 123 and fluid 124 are deposited in a tissue storage compartment of a sample tray of the tissue filter assembly 110, at 202, the x-ray imaging device 141 is activated to obtain an x-ray image 150 of the cut tissue sample 123. At 204, the image processor 160 executes an imaging algorithm to determine a structural or geometric configuration 172 of at least a portion of the sample tray imaged and depicted in the x-ray image 150, and at 206, executes a plurality of image masks 170 on each selected portion of the x-ray image 150 generated by the x-ray imaging device 141 based on the structural or geometric configuration 172. A resulting selectively modified x-ray image is generated by modifying certain pixels of the x-ray image 150. The corrected x-ray image 150m may then be presented to a user via the UI 182 of the display 180 at 208, or otherwise communicated or stored.

[0051] 3, in one embodiment of a computer-implemented method 200 generally performed by the tissue biopsy system 100 illustrated in FIG. 1, at 302, the x-ray imaging device 141 is initiated to obtain an x-ray image 150 of a tissue sample 123 in a storage compartment of a sample tray of the tissue filter assembly 110. At 304, the image processor determines a structural or geometric configuration 172 of at least a portion of the sample tray including the storage compartment with the tissue sample 123 imaged and depicted in the x-ray image 150. At 306, the image processor executes image masks 170 including an internal compartment mask and a partial structural mask based at least in part on the determined geometric configuration 171. At 308, the image processor 160 selectively modifies the x-ray image 150 based on the results of the mask execution and at 310 displays the modified x-ray image 150 to a user via the UI of the display 180.

[0052] Figures 4-7M illustrate an exemplary tissue biopsy system 100 and its tissue filter assembly 110 according to an embodiment that may be used to implement and / or perform X-ray image correction embodiments. Aspects of the exemplary tissue biopsy system components are described with reference to Figures 4-7M, and Figures 7E-M depict embodiments with different fluid management configurations and associated additional structures. Further details of X-ray correction and imaging algorithms utilizing the exemplary tissue filter assembly of Figures 7A-M are described with reference to Figures 8-11.

[0053] 4A-B, an exemplary tissue biopsy system 100 incorporating an embodiment for real-time correction of an x-ray image 150 of a tissue sample 123 is illustrated. In the illustrated embodiment, the exemplary tissue biopsy system 100 includes a main housing or cabinet 400 that includes an imaging cabinet 402 and a filter drawer 430. The filter drawer 430 can slide within the imaging cabinet 402 between an open position 431 (shown in FIG. 4A) and a closed position 432 (shown in FIG. 4B). In the open position 431, the filter drawer 430 can be ejected or pulled by a radiologist to extend outwardly from the imaging cabinet 402, thereby allowing for insertion and removal of a tissue filter assembly 110. The filter drawer 430 is pushed (or inserted) into the imaging cabinet 402 where the X-ray imaging device 141 (located inside the imaging cabinet 402) is positioned relative to the tissue filter assembly 110, thereby positioning the cut tissue sample 123 contained within the tissue filter assembly 110 within the field of view of the X-ray imaging device 141.

[0054] The X-ray imaging device 141 may be configured such that an X-ray image 150 is obtained with the X-ray imaging device 141 and then the tissue filter assembly 110 containing the tissue sample 123 is moved or rotated to position the next tissue sample 123 within the field of view for imaging. The position of the X-ray imaging device 141 may also be adjusted, but for ease of discussion, it is mentioned, without limitation, that the tissue filter assembly 110 or its sample tray is rotatable to place the tissue sample 123 within the field of view of the X-ray imaging device 141 in the imaging cabinet 402.

[0055] In the illustrated embodiment shown in FIG. 4A, the biopsy resection tool 120 communicates with a remote control 410, which is operable by a radiologist to activate and control the operating modes and other controls of the biopsy resection tool 120. FIGS. 4A-B also illustrate an aspiration canister 130 and associated exhaust suction line 132 in communication with the tissue filter assembly 110 through the main housing 400. The aspiration canister 130 may be a disposable canister that serves to collect, hold, and dispose of waste generated during a biopsy procedure, including one or more fluids 124, such as excess saline and / or blood, aspirated through the tissue filter assembly 110. The tissue biopsy system 100 may also include a foot switch 440 that allows the surgeon to manually activate and / or control the biopsy resection tool 120, and system mode or control status and / or system mode or control parameters can be displayed or adjusted via the technician control display 420.

[0056] FIG. 5 illustrates in further detail how the imaging cabinet 402 of the tissue biopsy system 100 may be configured. In the illustrated embodiment, the tissue filter assemblies 110, which define respective tissue storage compartments, are removably inserted into a filter drawer 430. The filter drawer 430 is slidably inserted into and removed from the imaging cabinet 402. The tissue filter assembly 110 is structured such that the tissue storage compartments are in communication with and positioned between the biopsy resection tool 120 via the inlet line 122 and the suction canister 130 via the exhaust suction or outlet tube 132. During use, tissue samples 123 and fluid 124 excised by the biopsy resection tool 120 are aspirated through the inlet line 122 and deposited into the tissue storage compartments of the tissue filter assembly 110. Excess fluid 124 may be aspirated through the exhaust suction line 132 into the suction canister 130. The imaging cabinet 402 includes (or houses) the X-ray imaging device 141, and the imaging cabinet 402 includes a detector plate 510 for detecting the emitted X-rays and generating the X-ray image 150. The tissue sample 123 is positioned within the field of view of the X-ray imaging device 141.

[0057] Image processor 160 may also be included within imaging cabinet 402, although embodiments are not so limited. For example, image processor 160 or components thereof may be located remotely relative to tissue biopsy system 100 to enable remote image processing, remote execution of image mask 170, and remote execution of machine intelligence and object detection within tissue sample 123. For ease of discussion, reference will be made to real-time imaging and acquisition of x-ray images 150.

[0058] The filter drawer 430 defines tubing channels 520 for the inlet line 122 and the outlet or aspiration line 132. A vacuum source (not shown) communicates with the aspiration or outlet line 132 and / or aspiration canister 130 such that activation of the vacuum source results in aspiration of the tissue sample 123 and fluid 124 through the inlet line 122 and into the tissue storage compartment of the tissue filter assembly 110. Waste or excess fluid may be aspirated into the aspiration canister 130 through the exhaust aspiration line 132.

[0059] 4A-B and with continued reference to FIG 5, the imaging cabinet 402 includes a control panel 460 with buttons or UI elements (for the control panel in the form of a touch screen) that allow a user to select or adjust various operating parameters (such as imaging parameters) or filters of the biopsy system 100 and request generation of a modified x-ray image 150m in accordance with an embodiment, and a display 180 is provided for presenting to the user the modified x-ray image 150m generated in accordance with an embodiment. In an embodiment, these parameters may be adjusted via one or more UI elements 182 on the display 180.

[0060] For example, image processor 160 may execute imaging algorithms that include one or more image masks 170 (such as a predetermined region of interest (ROI) mask to exclude portions of x-ray image 150 depicting metal collimator 142 of x-ray imaging device 141; a compartment mask performed on a portion of x-ray image 150 depicting the tissue storage compartment interior; a partial structure mask performed on a portion of x-ray image 150 depicting portions of the compartment interior not encompassed by the sample tray walls and compartment mask; one or more foreign object masks for other objects affixed to or embedded in the sample tray (such as magnets or printed indicia); and a background image mask, for example, for other plastic surrounding or base materials). Image processor 160 also communicates with computer display 180 of tissue biopsy system 100, and processes user interactions via UI 182, for example, processing user requests for x-ray image modifications according to an embodiment.

[0061] 6, an exemplary biopsy resection tool 120 and tissue filter assembly 110 are shown. The distal end of the biopsy resection tool 120 includes an introducer 620 for insertion of a biopsy needle 622, which is attached to a drive of the biopsy resection tool 120 and configured for tissue extraction. For these purposes, the proximal end of the biopsy resection tool 120 communicates with a saline / aspiration tubing assembly 610, which includes an inlet line 122 for delivery of saline fluid 124 and delivery of fluid to the filter assembly 110. The exemplary saline / aspiration tubing assembly 610 as shown in FIG. 6 may include an aspiration line 612 through which a tissue sample 123 excised by the needle 622 of the biopsy resection tool 120 is aspirated along with a fluid 124, such as saline, introduced via one or more inlet or saline lines 614. The excised tissue sample 123 and fluid 124 are aspirated through an aspiration line 612 which communicates with an inlet into the filter assembly 110. The outlet of the tissue filter assembly 110 is in fluid communication with the aspiration canister 130 via an exhaust aspiration line 132.

[0062] 7A-D illustrate an exemplary configuration of a tissue filter assembly 110 in fluid communication between a biopsy resection tool 120 and an aspiration canister 130. In the depicted embodiment, the tissue filter assembly 110 includes a housing or cover 710 and a base 730. The cover 710 removably mounts onto the base 730 and defines an interior or chamber in which a tissue sample holder or tray, or filter holder or sample tray 720 (generally, sample tray 720) is enclosed. The base 730 includes a spindle 732 that receives a hub 722 of the sample tray 720 such that the sample tray 720 is rotatable about an axis of rotation 740 defined by the spindle 732 and is rotatable relative to the base 730 and cover 710 about axis 740. In other words, the base 730 and cover 710 are stationary and the sample tray 720 rotates within a chamber defined by the base 730 and cover 710. The sample tray 720 can be rotated using any suitable actuator, including a magnetic drive system (not shown in FIGS. 7A-D) in which one or more magnetic elements are disposed on or embedded within the sample tray 720 and the sample tray 720 is rotated by the magnetic force of magnets in the actuator.

[0063] 7A-D, the base 730 includes a bottom member or surface 734 and a cylindrical circumferential outer sidewall 736 (generally, sidewall 736). The sidewall 736 extends upwardly from the bottom member 734 and has an inner diameter, and the sample trays 720 are rotatable by spindles 732 of the base 730 that receive the hubs 722 of each of the sample trays 720, thereby allowing the sample trays 720 to rotate about an axis of rotation 740.

[0064] 7A-D, the sample tray 720 also includes a bottom member, which may include a filter material 724, and a cylindrical circumferential sidewall 726 (generally, sidewall 726) extending upwardly from the bottom member 724. In an embodiment, the bottom surface 724 of the sample tray 720 includes a porous filter material. The filter material may be a single filter, such as a filter sheet, that covers the entire bottom of the sample tray 720, with excess fluid 124 flowing through the filter material and into the aspiration canister 130. Alternatively, the filter material may be individual filters disposed on the bottom of each tissue storage compartment 728.

[0065] The sample tray 720 also includes a plurality of interior or dividing walls 727 (generally, dividing walls 727) that extend radially from a center or hub 722 to the inner surface of the sidewall 726 and define respective tissue storage compartments 728. In the illustrated embodiment, the sample tray 720 defines twelve tissue storage compartments 728A-L (generally, tissue storage compartments 728). In the illustrated configuration, the sample tray 720 defines an angular arrangement of storage compartments 728 that are in the shape of a "pie" or "wedge" shaped segment, each of which is defined by two dividing walls 727 and an arcuate portion of the sidewall 726. The tissue storage compartments 728 are separated and partially defined by the radially extending dividing walls 727. It should be understood that the sample tray 720 may define other numbers of tissue storage compartments 728 and have other configurations, such that FIGS. 7A-D are provided for purposes of illustration and explanation, and not limitation.

[0066] During a biopsy procedure, tissue samples 123 and fluids 124 are aspirated through the biopsy needle 622 into the in-line tissue storage chamber 728. Tissue chamber indicia or identifiers 750a-l (generally, compartment indicia 750) are provided to identify each tissue storage compartment 728 and each tissue sample 123 therein. The compartment indicia 750 may be printed or engraved alphanumeric indicators. For example, radiopaque tungsten ink may be utilized for the compartment indicia 750 such that they are visible in the x-ray image 151. In the illustrated embodiment, the compartment indicia 750 are alphanumeric indicators in the form of the letters AL to identify each of the twelve tissue storage compartments 728A-L.

[0067] An embodiment may involve first reducing the fluid 124 in the tissue storage compartment 728 prior to imaging of the tissue sample 123. An embodiment is then performed for imaging of the tissue sample 123 in the presence of residual fluid 124.

[0068] According to one embodiment, a fluid management device 760 may be disposed within the base 730. The embodiment may involve removal of fluid 124 from the tissue storage compartment 728 using a mechanical device in the form of the fluid management device 760 to address fluid 124 remaining within the tissue storage compartment 728 and continuing to interfere with imaging of the severed tissue sample 123.

[0069] 7E-M depict another exemplary configuration of the filter assembly 110 in fluid communication between the biopsy resection tool 120 and the suction canister 130 and including additional structure for improved fluid management and for controlling the removal of fluid 124 from the tissue storage compartment 728. Figures 7E-M illustrate one embodiment of a tissue filter assembly 110 with a base 730 structurally configured for enhanced fluid management for receiving multiple tissue samples.

[0070] In the illustrated embodiment, the tissue filter assembly 110 includes a housing having a base 730 and a cover 710, which removably mounts onto the base 730. The base 730 and attached cover 710 form an interior or chamber in which the sample tray 720 is enclosed. As discussed above with reference to Figures AD, the base 730 has a hub with a spindle that receives the hub of the sample tray 720, such that the sample tray 720 is rotatable relative to the housing 710 about an axis 740, for example, using a magnetic drive system. The bottom of the tissue sample tray 720 has a tissue filter 724 comprising a porous filter material.

[0071] The base 730 has a bottom surface 734 and a circumferential sidewall 736 extending upwardly from the bottom surface 734. The tissue filter assembly 110 also includes a platform 760 with a platform opening 762. A fluid channel 764 is located below the platform 760 (see dashed arrow in FIG. 7E pointing to the fluid channel 764 below the platform 760). As used herein, the term "fluid channel" may be any passageway capable of transporting a fluid, such as a gas (e.g., air) and / or a liquid.

[0072] The platform 760 has a planar horizontal surface. In some embodiments, the bottom of the sample tray 720 may rest on the planar horizontal surface of the platform 760 as the sample tray 720 rotates relative to the base 730. In other embodiments, the bottom of the sample tray 720 may be spaced from the planar horizontal surface of the platform 760 by a short distance, such as less than 0.5 mm, less than 0.2 mm, less than 0.1 mm, or less than 0.05 mm. The fluid channel 764 extends circumferentially around the hub 731 of the base 730 below the platform 760 and is in fluid communication with a plenum 766 at the base 730. The suction line 132 is coupled to the plenum 766 for applying suction to the inside of the plenum 766 and the fluid channel 764. The tissue filter assembly 110 also includes a flow comb 768 located below the platform opening 762. In some embodiments, the flow comb 768 may extend from the platform opening 762 into the fluid channel 764. During use, fluid from the sample tray 720 is drawn into the platform opening 762 due to suction in the fluid channel 764 applied by the suction line 132. The flow comb 768 breaks up the fluid, which is transported by the fluid channel 764 around the hub 731 of the base 730 and reaches the plenum 766. The plenum 766 allows a volume of fluid to be collected while the fluid is sucked out of the plenum 766 through the outlet or vacuum port 770 by the suction line 132. In some embodiments, the outlet port 770 has an inner diameter of 0.26 inches. In other embodiments, the outlet port 770 may have an inner diameter of other dimensions that may be greater than or less than 0.26 inches.

[0073] In one embodiment, the fluid channel 764 extends circumferentially around the hub 731 of the base 730 approximately 270° (e.g., 270°±20°) such that the fluid in the fluid channel 764 travels an angular distance of approximately 270° circumferentially around the hub 731 to reach the plenum 766. In other embodiments, the fluid channel 764 may extend circumferentially around the hub 731 through other angular ranges. For example, the fluid channel 764 may extend around the hub 731 through an angle that is at least 180°. In the illustrated embodiment, the platform 760 also extends circumferentially around a majority of the space between the hub 731 and the circumferential sidewall 736. In other embodiments, the platform 760 may extend around the hub 731 a different extent than that shown.

[0074] As shown in FIG. 7E, this embodiment of the tissue filter assembly 110 also includes an imaging platform 772 corresponding to an imaging position for imaging the tissue sample 123. An imaging device may be located below the imaging platform 772. In particular, when a tissue sample 123 in the sample tray 720 is placed above the imaging platform 772, imaging may be performed by the imaging device below the imaging platform 772 to image the tissue sample 123. In some embodiments, the imaging platform 772 is a molded part having solid walls elevated above the bottom surface 734 to prevent fluid from collecting in and around the imaging area. During use, one of the tissue storage compartments 728 containing the tissue sample 123 to be imaged is placed above the imaging platform 772. In some cases, the filter or bottom surface 724 of the sample tray 720 may be located flush on the imaging platform 772. It should be noted that the imaging platform 772 is a separate part from the platform 766 and does not define any fluid channels.

[0075] 7F, the cover 710 also includes an elevated portion 711 that defines a vault compartment corresponding to an imaging location for the tissue sample 123. In particular, when a tissue storage compartment 728 containing the tissue sample 123 is positioned below the elevated portion 711 and above the imaging platform surface 772, imaging can be performed to image the tissue sample 123.

[0076] In some embodiments, the platform opening 762, the fluid channel 764, and the flow comb 768 may be considered part of the fluid removal mechanism. The fluid removal mechanism is configured to remove fluid from the bottom filter 734 below the bottom of the plurality of tissue storage compartments 728 to improve the quality of the acquired images of the tissue samples 123 in the tissue storage compartments 728. In other embodiments, structures involved in defining the fluid channel 764 may also be considered part of the fluid removal mechanism. For example, the platform 760 above the fluid channel 764 and / or the bottom member of the base 730 below the fluid channel 764 may be considered part of the fluid removal mechanism. In further embodiments, the plenum 766 and / or the suction line 132 may be considered part of the fluid removal mechanism.

[0077] 7G illustrates a partially transparent view of the tissue filter assembly 110. The cover 710 of the tissue filter assembly 110 is illustrated as being partially transparent so that the sample tray 720 beneath the cover 710 can be seen.

[0078] 7H illustrates the tissue filter assembly 110 with the cover 710 removed. A circumferential sidewall 736 of the base 730 defines a space for accommodating the sample tray 720. When the sample tray 720 is rotatably coupled to the base 730, the sample tray 720 is separated from the circumferential sidewall 736 by a gap 776. This allows the sample tray 720 to rotate relative to the base 730 without interference.

[0079] 7I illustrates the base 730 of the tissue filter assembly 110 with the cover 710 and sample tray 720 removed. As shown in FIG. 7I, the platform 760 of the base 730 of the tissue filter assembly 10 is presented in a partially transparent format to illustrate a portion of the flow comb 768 below the platform 760.

[0080] FIG. 7J specifically illustrates the base 730 of the tissue filter assembly 110 with the platform 760 removed from the base 730. The imaging platform 772 and the extent of the flow comb 768 can be seen. As shown in the figure, the base 730 includes a bottom member 780 surrounded by the circumferential sidewall 736 of the base 730. The bottom member 780 has an elevation below that of the flow comb 768. In some embodiments, the imaging platform 772 and / or the flow comb 768 may be molded together with the bottom member 780. As shown in the figure, the flow comb 768 has an arcuate shape that allows the fluid 124 to be transported from the platform opening 762 into the fluid channels 764 along a curved path. In the illustrated embodiment, the flow comb 768 has six parallel flow channels. In other embodiments, the flow comb 768 may have more than six parallel flow channels (e.g., seven, eight, nine channels, etc.) or fewer than six flow channels (e.g., five, four, three, two channels). In some cases, the flow comb 768 may include at least four flow channels. Further, in the illustrated embodiment, the flow comb 768 has a length that is longer than a dimension of the platform opening 762 measured along the longitudinal axis of the fluid channel 764. In other embodiments, the flow comb 768 has a length that is shorter than or equal to a dimension of the platform opening 762 measured along the longitudinal axis of the fluid channel 764. Further, in the illustrated embodiment, a first portion of the flow comb 768 adjacent the platform opening 762 may have a first slope that is approximately vertical (e.g., 90°±20°), a second portion of the flow comb 768 following the first portion may have a second slope that is about 45°±20°, and a third portion of the flow comb 768 following the second portion and extending inside the fluid channel 764 may have a third slope that is about 0°±20°. In other embodiments, the flow comb 768 may have other slope profiles. In some embodiments, a surface treatment may be applied to the flow comb 768 to aid in the flow of the fluid 124 over the flow comb 768.For example, in some embodiments, an anti-thrombogenic coating, a hydrophobic coating, or other treatment may be applied onto the surface of the flow comb 768.

[0081] 7K, the bottom member 780 and the platform 760 together define a fluid channel 764. The platform 760 and the fluid channel 764 are located below the sample tray 720 when the sample tray 720 is coupled to the base 730. The fluid channel 764 is configured to provide suction to transport the fluid 124 through the fluid channel 764.

[0082] FIG. 7L illustrates a partial cutaway view of the tissue filter assembly 110, particularly showing the sample tray 720 loaded inside the interior defined by the base 730 and the cover 710. The cover 710 includes a protrusion 782 configured to mate with an opening 784 in the hub 722 of the sample tray 720. A lower portion of the hub 722 of the sample tray 720 has an opening for receiving the hub 731 of the base 730, and the hub 722 includes a slot for receiving the spindle 732 of the base 730. Thus, rotation of the spindle 732 will rotate the sample tray 720 relative to the base 730. The protrusions 782 from the cover 110 and the hub 731 of the base 730 extend into the hub 722 of the sample tray 720 from opposite directions, thereby stabilizing the sample tray 720 during rotation. Thus, the sample tray 720 is removably coupled to a spindle 732 (drive member) at the base 730, thereby configured to be selectively rotated about an axis 140 that is substantially perpendicular (e.g., 90°±10°) to the bottom member 780.

[0083] 7L, the inlet ports 122 in the cover 110 are radially aligned with the respective tissue storage compartments 728 and also radially aligned with the platform openings 762 formed at least partially with the platform 760. Thus, when a tissue sample 123 with fluid 124 is delivered into the inlet ports 122, the tissue sample 123 and the fluid 124 are deposited in the respective tissue storage compartments 728. The tissue sample 123 is contained by the bottom filter 734, while the fluid 124 exits through the bottom filter 734 and through the platform openings 762 of the platform 760. During use of the tissue filter assembly 110, suction will be provided inside the fluid channels 764 to help draw the fluid 124 from the bottom of the sample tray 720 into the platform openings 762.

[0084] FIG. 7M illustrates a partial cutaway view of the tissue filter assembly 110 of FIG. 7L, particularly showing the fluid flow direction. As shown, tissue sample 123 and fluid 124 from biopsy device 120 enter tissue filter assembly 110 via inlet port 122. Tissue sample 123 is deposited in one of tissue storage compartments 728 in sample tray 720. Bottom filter 734 prevents tissue sample 123 from exiting through the bottom of sample tray 720 while allowing fluid 124 to pass through it. Due to suction provided in fluid channel 764, fluid 124 enters platform opening 762 in platform 760 and is broken down by flow comb 768 inside fluid channel 764. The fluid 124 is then transported through the fluid channel 764 due to the suction force inside the fluid channel 764 and exits into the plenum 766 via the exit port 97 in the circumferential sidewall 746. The plenum 766 allows a volume of the fluid 124 to be collected while the fluid 124 is being drawn out of the plenum 766 via the exit port and into the suction line 132.

[0085] Although various tissue filter assembly 100 configurations have been described with reference to Figures 7A-D and 7E-M, it should be understood that embodiments may involve or utilize various tissue filter assembly 100 configurations, including those with specifically configured mechanical fluid management devices 760 as described with reference to Figures 7E-M, to reduce the amount of fluid 124 imaged. Accordingly, certain fluid management devices 760 are described herein as non-limiting examples of how fluid 124 undergoing imaging may be reduced and removed from the tissue storage compartment 728. It should also be understood that embodiments may not involve a mechanical fluid management device 760.

[0086] Having described various aspects, structures, and operations of an exemplary tissue biopsy system 100 and its components that may be utilized in conjunction with an embodiment that processes an X-ray image 150 of a tissue sample 123 to generate a modified X-ray image 150m, the image processing embodiment described with reference to Figures 1-3 will be described in further detail with reference to the exemplary biopsy system 100 described above with reference to Figures 8-11 and Figures 4A-7M.

[0087] Referring to FIG. 8 , one embodiment of the image processor 160 of the tissue biopsy system 100 is configured (or operable) for selective X-ray image correction by executing an imaging algorithm that includes multiple image masks 170 based on a structural or geometric configuration 171 of at least a portion of the sample tray 720 imaged and depicted in the X-ray image 150.

[0088] At 802, a structural or geometric configuration 171 or template of the sample tray 720 is received or determined and stored by the image processor 160 for subsequent access. The structural or geometric configuration 171 may include geometric data of the tissue storage compartment 728, the side walls 726, and the inner dividing wall 727. The boundaries of the side walls 726, the dividing wall 727, and the tissue samples 123 within the tissue storage compartment 728 can be determined using the structural or geometric configuration data 171, including one or more or all of the component dimensions, center, center of rotation, and radius of curvature for various components, whether located in the middle of the tissue storage compartment 728 or in contact with the wall. The structural or geometric configuration 171 or template may take into account other objects embedded in or attached to the sample tray 720, such as predetermined printed indicia 750 and geometric data of a magnet or a compartment "zero" position object. The structural or geometric configuration 171 data may include, for example, the center of mass of the printed indicia 750, the location of the magnet relative to the storage compartment 728, the size or dimensions of the indicia 750 and the magnet, their centers, and, if applicable, their radii. Although the printed indicia and magnets are provided as examples of such objects, other objects and their image data may be processed depending on the sample tray 720 configuration and processing.

[0089] In the exemplary tissue biopsy system 100 described above, a single magnet may be sufficient for magnetically driven rotation of the sample tray 720, and such a magnet may be positioned, by way of example, between or adjacent to the compartment 728 with the printed indicia "A" (the magnet of the sample tray 720 is imaged as the lightest portion of FIG. 9 ) and the compartment 728 with the printed indicia "L". The magnet may not only rotate the sample tray 720, but may also serve as a compartment "zero" or reference marker. Thus, it should be understood that one or more storage compartments 728 may be adjacent to a magnet, while other storage compartments 728 are not.

[0090] At 804, the tissue biopsy system 100 is activated and utilized to cut a tissue sample 123. For example, as described above with reference to FIG. 6, this may involve inserting a biopsy needle 622 into the patient and attaching the biopsy needle 622 to a drive of the biopsy resection tool 120 for tissue extraction.

[0091] At 806, the cut tissue sample 123 is delivered through the lumen of the inlet line 122 via suction and deposited into the storage compartment 728 of the sample tray 720 of the tissue filter assembly 110. For example, as described above with reference to FIG. 6, the proximal end of the biopsy resection tool 120 communicates with the saline / suction tubing assembly 610 that includes the inlet line 122 for delivery of saline fluid 124 and delivery of fluid to the filter assembly 110, and the tissue sample 123 resected by the needle 622 of the biopsy resection tool 120 is aspirated along with the fluid 124 through the suction line 612 that communicates with an inlet into the filter assembly 110, depositing the cut tissue sample 123 and the fluid 124 into the storage compartment 128.

[0092] 8, at 808, the x-ray imaging device 141 is activated to obtain an x-ray image 150 of the tissue sample 123 in the storage compartment 728 and at least a portion of the sample tray 720. The x-ray image 150 is stored and / or provided to the image processor 160.

[0093] Figure 9 illustrates an example x-ray image 150 of a portion of a sample tray 720, including a storage compartment 728. Figure 9 is an x-ray image 150, rather than an actual sample tray 720, although reference numbers for the sample tray 720 and other structures are provided in Figure 9 for reference to identify the physical structures of the sample tray 720 depicted in the x-ray image 150.

[0094] In the illustrated example, the x-ray image 150 includes one complete sample compartment 728 defined by an arcuate, cylindrical, or circumferential outer sidewall 736o ("o" refers to "outside" and generally, outer sidewall 736o), an arcuate, cylindrical, or circumferential inner sidewall 736i ("i" refers to "inside" and generally, inner sidewall 736i), and inner dividing walls 727a-b. A tissue sample (not shown) is deposited in the storage compartment 728 and imaged by the x-ray imaging device 141.

[0095] 9 further illustrates an x-ray image 150 as generated by an x-ray imaging device 141 relative to a predetermined structural or geometric framework 171 including a rotation point or center of rotation (0) or axis 740 and associated x-axis 901 and y-axis 902. FIG 9 further illustrates how the sample tray 720 and compartment 728 structures depicted in the x-ray image 150 are represented relative to different references and radii, such as the center of rotation (0) or axis 740, the x-axis 901, and the y-axis 902.

[0096] In particular, line OA 911 extends from the center of rotation (0) or axis 740 through the center of the printed marking or indicia 750 and represents (or approximates) the vertical centerline of the storage compartment 728. The exemplary X-ray image 150 is an image of a sample tray 720 defining twelve tissue storage compartments (AL), with only one complete storage compartment 728 included within the X-ray image 150 and identified by the printed marking 750 "A". However, it should be understood that the embodiments are not so limited and that the X-ray image 150 is provided as an example to illustrate how the embodiments may be implemented. FIG. 9 also illustrates an example where the X-ray image 150 is not properly rotationally aligned. The line O-A 911 is displaced in a clockwise direction relative to the Y-axis 902. In other words, the line O-A 911 through the printed marking 750 "A" is not coincident with the Y-axis 902.

[0097] Line OB912 extends from the center of rotation (0) or axis 740 through approximately the center of dividing wall 727b. Line OC913 extends from the center of rotation (0) or axis 740 through approximately the center of dividing wall 727a. Thus, lines OB912 and OC913 effectively divide the imaged dividing wall 727b, 727c into two image sections, an "inner" wall section or inner wall and an "outer" wall section or outer wall that define at least a portion of the storage compartment 728. The arcuate side walls 736i, o in the x-ray image 150 may be similarly divided into "inner" and "outer" portions, although based on other structural criteria than lines OB and OC912, 913, as will be described in more detail below. As will be described in more detail below, an imaging algorithm according to an embodiment utilizes this virtual division of the sample tray wall 727 to generate a corrected x-ray image 150m.

[0098] FIG. 9 also illustrates different radii and curvatures relative to the center of rotation (0) or axis 740, including radius R1 921, which represents the virtual radius of outer sidewall 736o from axis 740, radius R2 922, which represents the virtual radius of inner sidewall 736i from axis 740, radius R3 923, which represents the virtual radius of wall 736m (where "m" refers to the magnet) relative to axis 740, and radius R4 924 and radius R5 925, which represent the respective virtual radii of the respective boundaries of the imaging mask 170, which will be described in further detail below.

[0099] The X-ray image 150 of FIG. 9 also includes dark corner areas 931 and peripheral bright areas 932 resulting from imaging a portion of the collimator 142 of the X-ray imaging device 141 that was in the field of view when the X-ray image 150 was obtained.

[0100] Referring again to FIG. 8, at 810, image processor 160 runs the ROI mask imaging mask 170 to remove image portions 931 and 932, for example using segmentation or other image processing or filters suitable for radiopaque / metal objects.

[0101] 8 and 9 , at 812, the image processor 160 identifies alignment and / or orientation references to determine whether the x-ray image 150 is properly laterally and / or rotationally aligned for correspondence to the known structural or geometric features 171 of the imaged sample tray 720. The alignment and / or orientation references may include, for example, the x-axis 901, the y-axis 902, and the center of rotation (0) 740. At 814, the image processor 160 identifies a printed indicia or landmark 750 (e.g., a printed "A") associated with the storage compartment 728 of the sample tray 720. The printed indicia or landmark 750 may be a predefined letter, shape, or indicator (e.g., letters "A" through "L") such that this limited set of predefined letters is identifiable by character recognition or selectable by the user via the UI 182 as the indicia 750 for the compartment 728. Upon identifying or receiving 816 a selection of the mark or landmark 750, the image processor 160 determines the center, e.g., center of mass, of the printed mark 750, which in the illustrated embodiment is identified by the line OA911. The line OA911 represents the estimated vertical centerline of the compartment 728.

[0102] At 818, the embodiment determines whether a rotational misalignment adjustment is required. This may be done by rotating the x-ray image 150 as necessary based on step 816 to correct the rotational positioning of the x-ray image 150. For example, in the illustrated example, the x-ray image 150 is not properly rotationally aligned as a result of the line O-A 911 being rotated clockwise relative to the Y-axis 902. In other words, the line O-A 911 is rotationally displaced because it is not aligned with the Y-axis 902. In this case, the x-ray image 150 is rotated until the line O-A 911 is aligned or coincident with the Y-axis 902. The x-ray image 150 may already be properly rotationally aligned such that no rotational adjustment is required. Additionally, in other embodiments, to accommodate the rotational misalignment, the orientation of the x-ray image may remain as captured, and the embodiment may instead rotate or reposition the image mask 170 and the structural or geometric features 171, as described in more detail below. The rotational adjustment, whether of the x-ray image 150 and / or the image mask 170 and the structural or geometric configuration 171, can be clockwise or counterclockwise.

[0103] 8 and 9, at 820, the image processor 160 determines the x-ray collimator offsets 941, 942 in the x-ray image 160, e.g., the left collimator offset 941 relative to the outer edge of the outer sidewall 736o and the right collimator offset relative to the outer edge of the inner sidewall 736i. In the illustrated example, the left collimator offset 941 is greater than the right collimator offset 942. The x-ray image 150 can be translated to the center at 822 such that the x-ray image 150 depicting the sample tray 720 or a portion thereof corresponds to a known structural or geometric configuration 171 of the sample tray 720 or a portion thereof. There may be instances where the x-ray image 150 is already properly centered and no offset adjustment is required. Additionally, in other embodiments, the x-ray image position can remain as imaged and embodiments can instead reposition the image mask 170 and the structural or geometric configuration 171 to accommodate the collimator offsets. Thus, the embodiments can accommodate manufacturing imperfections and collimator offsets during imaging, whether such imperfections result in rotational and / or offset adjustments.

[0104] Thus, after any rotation and / or offset adjustments, the x-ray image 150 of the sample tray 720 or portion thereof corresponds to the known structural or geometric configuration 171 of the actual sample tray 720 or portion thereof. An image mask 170 based on the structural or geometric configuration 170 is ready to be performed on the x-ray image 150.

[0105] At 824 , the image processor 160 executes an imaging algorithm that includes a compartment mask 951 that is executed on a portion of the x-ray image 150 that depicts the interior area of ​​the storage compartment 728 . The compartment mask 951 substantially conforms to the interior contour of the storage compartment 728 defined by the walls of the sample tray 720, which in the illustrated embodiment include the dividing wall 727 and the arcuate sidewall 736 and the arcuate wall portion 956 (resulting from imaging of the magnet 953). Different magnet shapes will result in different image 953 profiles, whereby the shape of the wall portion 956 will reflect such shape. Furthermore, in the absence of a magnet, the outer sidewall 936o will extend between the dividing walls 727a,b without the wall portion 956 resulting from the magnet imaging. It should thus be understood that FIG. 9 is provided for purposes of illustration and not limitation.

[0106] The compartment mask 951 enhances at least one of the brightness and contrast of pixels of the x-ray image 150 depicting the tissue sample 123 within the boundaries of the compartment mask 951. In the illustrated embodiment and depicted sample tray 720 configuration, the boundaries of the compartment mask 951 include a pair of linear boundary segments, a pair of arcuate boundary segments extending between the linear boundary segments, and an arcuate segment that follows the contour of the wall segment 956 adjacent the portion of the x-ray image of the imaged magnet. It should be understood that the compartment mask 951 boundaries may be different shapes depending on the shape of the tissue storage compartment 728, such that the linear / arcuate configurations shown in the figures and described herein are provided for purposes of illustration and explanation, not limitation. As such, the compartment mask 951 boundaries are contained within the interior of the storage compartment 728, exclude the dividing walls 727a-b, and exclude the side walls 736i, 736o, and wall portion 56. The compartment mask 951 boundaries also exclude the X-ray collimator 142 being in the field of view, positioning the magnet of the sample tray 720, and the result of other objects outside the storage compartment 728, or dark areas 931 and areas 932.

[0107] In the illustrated embodiment of FIG. 9 where the X-ray image 150 includes an imaged magnet, the wall structure and shape of the compartment mask 951 changes compared to when the adjacent storage compartment 728 does not have a magnet and no magnet is imaged. In either case, the compartment mask 951 substantially follows the inner contour of the compartment 728 and, with the imaged magnet as illustrated, includes a first linear boundary segment, a second linear boundary segment, a first arcuate boundary segment, a second arcuate boundary segment, and a third arcuate boundary segment. The first arcuate boundary segment of the compartment mask 951 extends between the first linear boundary segment and the second linear boundary segment, the second arcuate boundary segment of the compartment mask extends between the first linear boundary segment and the third arcuate boundary segment, and the third boundary segment of the compartment mask extends between the second arcuate boundary segment and the second linear boundary segment. In the embodiment illustrated in FIG. 9 , the radius of curvature of the third arcuate section of compartment mask 951 adjacent arcuate wall portion 956 is smaller than the respective radii of curvature of the first and second arcuate boundaries of compartment mask 951 and each of the other masks due to the circumferential curvature of the imaged area of ​​the magnet.

[0108] 8 and 9, at 826, the image processor 160 executes an imaging algorithm that includes a partial structure mask 952 on a portion of the X-ray image 150 depicting the respective walls (inner wall 727 and outer / inner sidewalls 736i, 736o) of the sample tray 720 and the storage compartment 728. The boundary of the partial structure mask 952 extends around (or encompasses) the compartment mask 951.

[0109] The boundary of the partial structure mask 952 extends along and partially through the length of each of the walls 727, 736 of the sample tray 720, capturing the respective inner wall segments of each wall of the sample tray 720 and the remaining portion of the storage compartment 728 beyond the boundary of the sample image mask 951. Thus, the partial structure mask 952 is applied to a portion of the X-ray image 150 depicting the sample wall structure, determined, for example, based on the image portion inside the lines O-B 912 and O-C 913 or based on a predetermined distance from the boundary of the compartment mask 951. The partial structure mask 952 is performed to mask out the image portion or to reduce at least one of the brightness and contrast of the pixels of the X-ray image 150 depicting the outer portion of each sample tray wall 727a, b and 736i, o, thereby leaving only the inner portions of the sample tray walls 727a, b and 736i, o. In other words, the partial structure mask 952 cuts the thickness of the wall, for example, preserving 25%, 33%, or 50% of the wall thickness, while other wall portions are treated by reducing their brightness and / or contrast.

[0110] Thus, in x-ray image 150 without the imaged magnet, the boundary of partial structure mask 952, like the boundary of compartment mask 951, includes a pair of linear boundary segments and a pair of arcuate boundary segments extending between the linear boundary segments such that the partial structure mask is substantially the same shape as, but may encompass, compartment mask 951. As shown in FIG. 9, in x-ray image 150 with a portion relating to the imaged magnet, compartment mask 951 and partial structure mask 952 may have different shapes due to compartment mask 951 including additional curvature as a result of the imaged magnet and resulting wall portions 956. Further, as shown in FIG. 9, with an imaged magnet, a portion of the partial structure mask 952 may extend through a portion of the X-ray image 150 generated by imaging of the magnet or other foreign object, or in other embodiments, may follow the curvature of the compartment mask 951 through the wall portion 956 such that both the compartment mask 951 and the partial structure mask have a similar shape.

[0111] At 828, the image processor 160 identifies or receives a user selection of the X-ray image 150 portions related to "foreign" objects located outside the storage compartment 728 area, such as magnets and printed marks. At 830, the image processor 160 identifies and executes a respective foreign object image mask 953, 954 for each identified object. A portion of the X-ray image 150 generated by imaging a metal magnet may be a bright spot 960 or a high attenuation object as depicted in FIG. 9, in which case the metal mask 953 for the same would substantially reduce at least one of the brightness and contrast of the X-ray image 150 or remove this area and fill it with the pixel values ​​of the adjacent image area. Other objects may be processed differently. For example, it may be desirable to keep the imaged printed marks 750 so that the object mask 954 for these mark objects selects the ROI containing the printed marks 750 to be included in the modified X-ray image 150m. Such text objects can be identified by a user via the UI 182 or via character recognition. Thus, portions of the X-ray image 150 relating to different types of foreign objects may be processed with different types of foreign object masks 953, 954 that de-emphasize or remove portions of the X-ray image 150 or that preserve and / or enhance portions of the X-ray image 150.

[0112] At 832, the image processor 160 runs a background image mask 955 over other portions of the x-ray image 150 depicting other areas of the sample tray 420. This may involve, for example, other plastic sample tray structures or plastic structures utilized for fluid management and located outside the partial structure mask 952 or between the partial structure mask 952 boundary and the ROI mask boundary. These background structures, which may include various added structures for enhanced fluid management control, can be masked out or de-emphasized.

[0113] At 834, the image processor 160 determines contrast and / or brightness adjustments to adapt pixel values ​​to respective thicknesses of the tissue sample 123. A statistical analysis of the portion of the X-ray image 150 depicting the tissue sample 123 can be analyzed using one or more of statistical analyses such as mean, standard deviation, and thresholding to identify portions of the X-ray image 150 depicting thinner portions of the sample 123 as opposed to thicker portions of the sample 123, and thus pixel adjustments can be made based on different sample thicknesses, for example, pixel brightness values ​​for the thinner and thicker sample 132 portions can be enhanced with respective brightness and contrast, and thus sample edges of both the thinner and thicker sample 132 portions can be depicted with the thicker sample 132 portions being too bright. Thus, pixel values ​​can be selectively adapted across the sample 123 thickness.

[0114] At 836, a modified x-ray image 150m is generated based on the respective results of running the various image masks 170 or based on the respective results of running the various image masks 170 and sample thickness matching.

[0115] Figure 10A is a light x-ray image 150 (before being processed with an embodiment) generated by x-ray imaging device 141 depicting the magnet (imaged as a highly attenuating / bright spot), and Figure 10B is a modified x-ray image 150m generated in accordance with an embodiment.

[0116] As can be seen by comparing FIG. 10A (raw x-ray image 150) with FIG. 10B (modified x-ray image 150m generated by an embodiment), the modified x-ray image 150m generated according to the embodiment is cleaner, smaller, more focused, and includes a more consistent or flatter brightness profile or less brightness dispersion. The modified x-ray image 150m does not include bright high attenuation image portions (e.g., resulting from imaging metal magnets or plastic portions of the sample tray 720). The embodiment also de-emphasizes or eliminates image portions related to additional tray structures, such as additional plastic structures used for fluid management in the tissue filter assembly 100 described above with reference to FIGS. 7E-M. The modified x-ray image 150m of FIG. 10B is significantly more pleasing to the eye with substantially reduced distracting elements. The modified X-ray image 150m generated in accordance with the embodiment is less distracting than the X-ray image 150 shown in FIG. 10A and is less likely to contribute to eye fatigue while providing a more productive and efficient scanning experience.

[0117] 11A-B provide another example of a modified x-ray image 150m generated in accordance with an embodiment of a different tissue storage compartment 728 (identified by printed indicia "G") that is not adjacent to the magnet and that contains a tissue sample 123 deposited therein. Similar advantages of the modified x-ray image 150m of FIG. 11B over the raw x-ray image 150 as shown in FIG. 11A are visually apparent, including enhancing the tissue sample 123 within the tissue storage compartment 728 while reducing or eliminating enhancement of image portions relating to other plastic sample tray areas.

[0118] Referring again to FIG. 8, at 838, the modified X-ray image 150m pixel data is incorporated into a Digital Imaging and Communications in Medicine (DICOM) object, which at 840 can be exported for display to a user or communicated to another system or over a network.

[0119] Thus, as described above, the embodiments selectively emphasize certain image portions while excluding or de-emphasizing other image portions through the use of selective image masking based on the structural or geometric configuration of the imaged sample tray to provide improved tissue sample imaging and enhanced x-ray images. The embodiments achieve these significant imaging improvements in tissue image processing, which may be in real-time during or after the biopsy procedure, so that the improved imaging results may be presented to an operator who may perform a more accurate and efficient analysis and determine, for example, whether additional tissue samples should be obtained. The embodiments are also adaptable to a variety of system component configurations and tissue sample and biopsy procedures, one example of which is a breast biopsy procedure.

[0120] While particular embodiments of the disclosed invention have been shown and described, it is to be understood that the above description is provided for purposes of illustration and example only. Thus, various changes and modifications can be made without departing from the scope of the disclosed invention.

[0121] For example, not all of the components depicted and described in the disclosed embodiments are required to implement the embodiments, and various additional embodiments of the disclosed inventions may include any suitable combination of the described components, including different numbers and combinations of imaging masks.

[0122] Additionally, while embodiments have described tissue filter assemblies, sample trays, and associated imaging masks having certain shapes (with linear and / or curved / arcuate walls), it should be understood that the embodiments are not so limited and that the embodiments may involve sample trays with different configurations and compartment configurations that may include different combinations of linear and curved / arcuate walls and / or other shaped walls for other sample storage compartment shapes and sample tray configurations, and imaging masks with different respective shapes for the different configurations.

[0123] Embodiments may be implemented to generate modified x-ray images that mask out or de-emphasize different portions of the tissue filter assembly and sample tray depending on the particular structural configurations utilized. For example, embodiments may be implemented to mask out or de-emphasize additional plastic or other material structures added for fluid management as described with reference to Figures 7E-M, where the tissue filter assembly may include different fluid management structures.

[0124] Although the systems and methods have been described with reference to imaging breast tissue samples obtained during a biopsy procedure, embodiments can also be configured and utilized with other types of tissue samples.

[0125] Furthermore, although the imaging algorithms have been described with reference to various imaging masks, embodiments may involve some or all of these masks being performed in different sequences and different combinations thereof.

[0126] Accordingly, the embodiments are intended to illustrate alternatives, modifications, and equivalents that may fall within the scope of the claims.

Claims

1. 1. A computer-implemented method executed by a biopsy tissue handling device, the computer-implemented method comprising: obtaining an x-ray image of the tissue sample in a storage compartment of a sample tray with an x-ray imaging system of the biopsy tissue handling device; generating a modified x-ray image by an image processor in communication with the x-ray imaging system; Including, The modified x-ray image is generated by executing a plurality of image masks based at least in part on a geometric configuration of at least a portion of the sample tray including the storage compartment with the tissue sample depicted in the x-ray image, the plurality of image masks comprising: a compartment mask that depicts a storage compartment and that is executed on a portion of the x-ray image that includes the cut tissue sample, the boundaries of the compartment mask substantially corresponding to an interior contour of the storage compartment defined by walls of the sample tray; a partial structure mask executed on a portion of the X-ray image depicting the sample tray and each wall of the storage compartment; Equipped with A computer-implemented method, wherein boundaries of the partially structured masks extend along their respective lengths partially through their respective walls of the sample tray.

2. The method of claim 1 , wherein the compartment mask enhances at least one of brightness and contrast of pixels of the x-ray image depicting the tissue sample.

3. The method of claim 1 , wherein the compartment mask excludes walls of the storage compartment, an imaging portion of a collimator of the X-ray imaging device, and a magnet used to rotate the sample tray about an axis.

4. The method of claim 1 , wherein the boundary of the partial structure mask is based on a predetermined distance from the boundary of the compartment mask.

5. 2. The method of claim 1, wherein the partial structure mask is implemented to mask out or reduce at least one of brightness and contrast of pixels of the X-ray image depicting outer portions of each plastic wall of the sample tray outside the boundary of the partial structure mask.

6. The method of claim 1 , wherein the boundary of the partial structure mask and the boundary of the compartment mask have substantially similar shapes.

7. The method of claim 6 , wherein the boundary of the compartment mask includes a pair of linear boundary segments and a pair of arcuate boundary segments extending between the linear boundary segments.

8. 10. The method of claim 1, wherein the plurality of image masks further comprises a foreign object mask that is performed on a portion of the X-ray image depicting an object embedded in or affixed to the sample tray.

9. 9. The method of claim 8, wherein the boundary of the compartment mask and the boundary of the partial structure mask have different shapes compared to the boundary of the foreign object mask, and the shape of the boundary of the compartment mask differs from the shape of the boundary of the partial structure mask as a result of executing the foreign object mask.

10. the boundary of the compartment mask includes a first linear boundary segment, a second linear boundary segment, a first arcuate boundary segment, a second arcuate boundary segment, and a third arcuate boundary segment; the first arcuate boundary section of the compartment mask extends between the first linear boundary section and the second linear boundary section; the second arcuate boundary section of the compartment mask extends between the first linear boundary section and the third arcuate boundary section; the third boundary section of the compartment mask extends between the second arcuate boundary section and the second linear boundary section; a radius of curvature of the third arcuate section of the compartment mask is less than a radius of curvature of each of the first and second arcuate boundaries of the sample and partial structure masks, respectively; 10. The method of claim 9.

11. The method of claim 8 , wherein a portion of the boundary of the partial structure mask extends through an area defined by the boundary of the foreign object mask.

12. 9. The method of claim 8, wherein the object is a magnet utilized to rotate the sample tray about an axis, the boundary of the foreign object mask comprising a magnet mask substantially corresponds to an outer periphery of the magnet depicted in the X-ray image, and the magnet mask substantially reduces at least one of brightness and contrast of pixels of the X-ray image depicting the magnet.

13. 9. The method of claim 8, wherein the object is a printed indicia associated with the storage compartment, and a boundary of the foreign object mask comprising the printed indicia mask defines an area to be included in the modified image.

14. 2. The method of claim 1, wherein the plurality of image masks further comprises a predetermined region of interest mask operable to crop the x-ray image to exclude portions of the x-ray image depicting a collimator of the x-ray imaging system.

15. 2. The method of claim 1, wherein the geometric configuration of at least a portion of the sample tray depicted in the X-ray image is based at least in part on a center of a printed indicia associated with the storage compartment, and further comprising rotating the X-ray image to align the center of the printed indicia with a predetermined axis.

16. 10. The method of claim 1, further comprising determining an offset value of a collimator of the X-ray imaging device, wherein the geometric configuration of the at least a portion of the sample tray depicted in the X-ray image is based at least in part on the determined offset value.

17. The method of claim 1 , wherein the multiple image masks are performed in real-time during processing of the sectioned tissue sample.

18. The method of claim 1 , further comprising modifying brightness values ​​of pixels of the X-ray image to match respective brightness levels to respective thicknesses of the imaged tissue sample.

19. 1. A biopsy tissue handling device, comprising: a sample tray defining a storage compartment; a tube defining a vacuum lumen in communication with the storage compartment, the tube configured to receive a cut tissue sample and deliver the cut tissue sample along with a fluid through the vacuum lumen, whereby the cut tissue sample and the fluid are deposited in the storage compartment; an x-ray imaging system positioned relative to the tissue storage compartment to obtain x-ray images of the cut tissue samples within the storage compartment; an image processor in communication with the x-ray imaging system, The image processor is configured to generate a modified x-ray image by executing a plurality of image masks based at least in part on a geometric configuration of at least a portion of the sample tray including the storage compartment with the tissue sample depicted in the x-ray image, the plurality of image masks comprising: a compartment mask that depicts the storage compartment and that is executed on a portion of the X-ray image that includes the cut tissue sample, the boundaries of the compartment mask substantially corresponding to an interior contour of the storage compartment defined by respective walls of the sample tray; a partial structure mask executed on a portion of the X-ray image depicting the sample tray and each wall of the storage compartment; Equipped with the boundaries of the partially structured masks extend along their respective lengths partially through their respective walls of the sample tray; An image processor; a display in communication with said image processor; Equipped with The display is operable to present the modified image to a user of the biopsy tissue handling device.

20. A non-transitory computer readable medium tangibly embodying one or more sequences of instructions, the execution of which by one or more processors contained within one or more computing systems of a biopsy tissue handling device causes the one or more computing systems to obtain and modify x-ray images by performing a computer-implemented method; The computer-implemented method comprises: obtaining an x-ray image of the tissue sample in a storage compartment of a sample tray with an x-ray imaging system of the biopsy tissue handling device; generating a modified x-ray image by an image processor in communication with the x-ray imaging system; Including, the modified x-ray image is generated by executing a plurality of image masks based at least in part on a geometric configuration of at least a portion of the sample tray including the storage compartment with the tissue sample depicted in the x-ray image; The plurality of image masks include: a compartment mask that depicts the storage compartment and that is executed on a portion of the X-ray image that includes the cut tissue sample, the boundaries of the compartment mask substantially corresponding to an interior contour of the storage compartment defined by respective walls of the sample tray; a partial structure mask executed on a portion of the X-ray image depicting the sample tray and each wall of the storage compartment; Equipped with the boundaries of the partially structured masks extend along their respective lengths partially through their respective walls of the sample tray.

Images