Cleansing composition for oral appliances

Abstract

The present invention relates to a cleanser composition for intraoral appliances that has high cleaning performance and is capable of exhibiting excellent denture plaque removal effects. The present invention relates to a composition comprising the following components (A) and (B): (A) 0.05% by mass or more and 8% by mass or less of an anionic homopolymer or copolymer having a weight average molecular weight of 2,000 or more and 500,000 or less, which contains a structural unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphate group (B) one or more surfactants selected from anionic surfactants, nonionic surfactants, and amphoteric surfactants wherein the mass ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.05 or more and 50 or less, and the content of alcohol (C) having 2 to 6 carbon atoms is less than 8 mass%.

Description

[Technical field]

[0001] The present invention relates to a cleansing composition for intraoral instruments. [Background technology]

[0002] With the recent rapid aging of society, the number of people who are forced to wear removable intraoral appliances such as dentures is increasing at an accelerating rate. Such removable intraoral appliances, such as dentures and orthodontic appliances, tend to retain denture plaque, food residue, and other dirt that adheres to the appliance during wear. Furthermore, wearing the intraoral appliance with denture plaque remaining on it may cause bad breath, dental caries, periodontal disease, and the like. Therefore, in order to maintain physical health, it is necessary to keep intraoral appliances clean, and detailed daily care is essential.

[0003] In this context, various compositions have been developed to contribute to the practice of caring for intraoral appliances. For example, Patent Document 1 discloses a color-inhibiting coating agent made of an anionic polymeric compound and / or its salt, which has a specific carboxyl group content. Patent Document 2 discloses a liquid composition for cleaning dentures that is applied by application, which contains a nonionic surfactant, a cationic bactericide, a sulfite, and a water-soluble polymeric substance in specific amounts and mass ratios, and has a specific pH value, and which enhances the effect of removing stains from dentures and the antiseptic power of the immersion liquid when immersing dentures in the liquid. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2000-247851 A [Patent Document 2] JP 2010-280588 A Summary of the Invention [Problem to be solved by the invention]

[0005] However, the stain-inhibiting coating agent described in Patent Document 1 is merely a technology for inhibiting staining by applying the agent to dentures or the like in advance to prevent the accumulation of stains, and is not a technology intended to remove denture plaque that has already firmly adhered to intraoral appliances such as dentures. Even the composition described in Patent Document 2 requires long-term application using an immersion liquid or dissolving liquid, or physical additional force such as brushing, and there is still room for improvement in order to achieve better cleaning of intraoral appliances.

[0006] Therefore, the present invention relates to a cleanser composition for intraoral instruments having high cleaning performance that can exert an excellent denture plaque removing effect. [Means for solving the problem]

[0007] Therefore, the present inventors conducted extensive research to solve the above problems, and as a result, discovered a cleanser composition for intraoral appliances that contains a specific anionic homopolymer or copolymer and a specific surfactant, and that has a limited content of a specific alcohol, and is therefore capable of removing denture plaque that is firmly attached to intraoral appliances such as dentures.

[0008] That is, the present invention relates to a composition comprising the following components (A) and (B): (A) 0.05% by mass or more and 8% by mass or less of an anionic homopolymer or copolymer having a mass average molecular weight of 2,000 or more and 500,000 or less, which contains a structural unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphate group (B) One or more surfactants selected from anionic surfactants, nonionic surfactants, and amphoteric surfactants Contains The mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.05 or more and 50 or less, and The present invention provides a cleansing agent composition for intra-oral instruments, which contains less than 8 mass % of a monohydric or dihydric alcohol (C) having from 2 to 6 carbon atoms. Effect of the Invention

[0009] The detergent composition for intraoral appliances of the present invention can exhibit an excellent denture plaque removal effect even with short-term application. Therefore, with the detergent composition for intraoral appliances of the present invention, even if the application time to intraoral appliances is shortened, it is possible to effectively remove denture plaque from intraoral appliances, and high cleaning performance can be realized. As described above, the cleanser composition for intra-oral instruments of the present invention exerts excellent effects even with short-term application, making it easy to increase the frequency of application, thereby enabling the continuous use of clean intra-oral instruments while reducing the burden on users in caring for their intra-oral instruments. Furthermore, with the cleanser composition for intra-oral instruments of the present invention, high cleaning performance can be experienced without the need for long-term application of an immersion liquid or dissolution liquid, or excessive additional physical force such as brushing, and repeated use multiple times per day can be easily achieved. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The present invention will be described in detail below. In this specification, the term "oral appliance" refers to a dental appliance that needs to be worn and removed in the oral cavity, such as a complete denture, a partial denture, an orthodontic appliance, a retainer (hereinafter, these are also collectively referred to as "dentures, etc."), or a mouthpiece, a mouthguard, etc. Specifically, for example, a complete denture (total denture) is a denture to be worn on an edentulous jaw, and is composed of artificial teeth and a denture base. On the other hand, a partial denture (partial denture) is a denture to be worn on a jaw that has lost some teeth, and is composed of artificial teeth, a denture base, and abutment devices such as clasps, rests, and attachments, and orthodontic appliances, retainers, and mouthpieces have a similar structure. The denture base is generally made of resin such as acrylic resin, and the artificial teeth and abutment devices are generally made of metals such as titanium, ceramics, etc. in addition to the above resins. The mouthpiece and mouthguard are generally made of resin such as ethylene vinyl acetate. In addition, in this specification, "denture plaque" means an aggregate of bacteria attached to intraoral appliances and extracellular substances produced by the bacteria.

[0011] The cleansing composition for intraoral appliances of the present invention contains, as component (A), an anionic homopolymer or copolymer having a mass average molecular weight of 2,000 to 500,000, which contains a constituent unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphate group. This specific anionic homopolymer or copolymer (A), in combination with component (B) described below, is strongly adsorbed to the surface of denture plaque firmly attached to an intraoral appliance removed from the oral cavity, disrupting the aggregated structure of denture plaque and effectively detaching the denture plaque from the intraoral appliance, and is therefore considered to exert an excellent denture plaque removal effect and enhance cleaning performance.

[0012] From the viewpoint of effectively exerting the denture plaque removing effect, the mass average molecular weight of component (A) is 2,000 or more, preferably 3,000 or more, more preferably 6,000 or more, and even more preferably 10,000 or more. Moreover, from the viewpoint of ensuring good solubility or dispersibility of each component and effectively exerting the denture plaque removing effect, the mass average molecular weight of component (A) is 500,000 or less, preferably 350,000 or less, more preferably 200,000 or less, even more preferably 100,000 or less, and even more preferably 50,000 or less. The mass average molecular weight of component (A) is from 2,000 to 500,000, preferably from 3,000 to 350,000, more preferably from 6,000 to 200,000, even more preferably from 10,000 to 10,0000, and still more preferably from 10,000 to 50,000. The mass average molecular weight (Mw) refers to a value determined by gel permeation chromatography (using chloroform solvent, a calibration curve established using linear polystyrene as a standard, and a refractive index detector).

[0013] Component (A) is an anionic homopolymer or copolymer containing a structural unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphoric acid group. Specific examples of the monomer (a1) constituting component (A) include one or more selected from acrylic acid, methacrylic acid, itaconic acid, maleic acid, fumaric acid, sulfonic acid, styrenesulfonic acid, methacryloyloxyalkylsulfonic acid, methacrylamide alkylsulfonic acid, acryloyloxyalkylphosphate, and anhydrides thereof, monomers partially substituted with alkyl groups, and sugar-derived monomers such as glycopyranose in which a carboxymethyl group is bonded to a portion of a hydroxyl group. Among them, a monomer not containing an aromatic ring or an alicyclic ring in the molecular structure is preferred, and one or more selected from acrylic acid, methacrylic acid, maleic acid, and sulfonic acid are more preferred.

[0014] Furthermore, component (A) may be a homopolymer consisting of structural units derived from only one type of monomer (a1), or may be a copolymer consisting of structural units derived from two or more types of monomer (a1), or may be a copolymer consisting of structural units derived from monomer (a1) and structural units derived from monomers other than monomer (a1).

[0015] The content of the structural units derived from monomer (a1) in 100% by mass of all structural units of component (A) is, from the viewpoint of effectively ensuring the exertion of an excellent denture plaque removal effect, preferably 15% by mass or more, more preferably 35% by mass or more, even more preferably 50% by mass or more, and preferably 100% by mass or less.

[0016] Specific examples of component (A) include one or more selected from acrylic acid homopolymer, methacrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, acrylic acid / sulfonic acid copolymer, vinyl acetate / maleic acid copolymer, phosphinic acid / acrylic acid copolymer, and carboxymethylcellulose. Among them, from the viewpoint of exerting an excellent denture plaque removal effect and also effectively exerting a denture plaque formation suppression effect, one or more selected from acrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, and acrylic acid / sulfonic acid copolymer are preferred, one or more selected from acrylic acid / maleic acid copolymer and acrylic acid / sulfonic acid copolymer are more preferred, and acrylic acid / maleic acid copolymer is even more preferred.

[0017] The mass ratio of the constituent units derived from acrylic acid monomers to the constituent units derived from maleic acid monomers constituting the acrylic acid / maleic acid copolymer (acrylic acid / maleic acid) is preferably 0.01 to 99, more preferably 0.05 to 50, and even more preferably 0.1 to 10.

[0018] The content of component (A) in the cleanser composition for intraoral instruments of the present invention is 0.05% by mass or more, preferably 0.07% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, from the viewpoint of exerting an excellent denture plaque removing effect. Also, the content of component (A) in the cleanser composition for intraoral instruments of the present invention is 8% by mass or less, preferably 7% by mass or less, more preferably 6% by mass or less, even more preferably 5% by mass or less, and even more preferably 4% by mass or less, from the viewpoint of ensuring good solubility or dispersibility of each component. The content of component (A) in the cleanser composition for intraoral instruments of the present invention is 0.05% by mass or more and 8% by mass or less, preferably 0.07 to 7% by mass, more preferably 0.1 to 6% by mass, even more preferably 0.2 to 5% by mass, and even more preferably 0.3 to 4% by mass.

[0019] The cleansing composition for intra-oral instruments of the present invention contains, as component (B), one or more surfactants selected from anionic surfactants (b1), nonionic surfactants (b2), and amphoteric surfactants (b3), thereby ensuring good solubility or dispersibility of each component including component (A), and thereby exhibiting an excellent denture plaque removing effect and improving cleaning performance.

[0020] Examples of the anionic surfactant (b1) include one or more selected from fatty acid salts such as oleates and laurates; alkyl sulfates such as lauryl sulfate, myristyl sulfate, palmityl sulfate, stearyl sulfate, octyl sulfate, and capryl sulfate; alkyl sulfonates such as alkylbenzenesulfonates, α-olefinsulfonates, and hydroxyalkanesulfonates; acylamino acid salts such as acyl glutamates and acyl sarcosines; N-methyl long-chain acyltaurates such as lauryl methyl taurine; alkyl phosphates such as alkyl phosphates; higher fatty acid sulfonated monoglycerides, fatty acid ester salts of isethionic acid; and polyoxyethylene monoalkyl phosphates. Among these, from the viewpoint of enhancing the excellent denture plaque removal effect, it is preferable to use one or more selected from fatty acid salts, alkyl sulfates, and acylamino acid salts. The anionic surfactant (b1) preferably has a mass average molecular weight of less than 2,000. Among the fatty acid salts, from the viewpoint of enhancing the excellent denture plaque removal effect, fatty acid salts having an alkyl or alkenyl group with 12 to 20 carbon atoms are preferred, and fatty acid salts having an alkenyl group with 16 to 18 carbon atoms are more preferred.

[0021] Examples of the nonionic surfactant (b2) include one or more selected from polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters such as monostearate glyceride, alkyl glucosides, polyglycerin fatty acid esters such as monostearate decaglyceride and monomyristate decaglyceride, polyoxyethylene monoalkyl (or alkenyl) ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkylphenyl ethers such as polyoxyethylene nonylphenyl ether, fatty acid alkanolamides such as coconut oil fatty acid diethanolamide, and polyethylene glycol fatty acid esters. Among these, from the viewpoint of exerting an excellent denture plaque removing effect with high rapidity, polyoxyethylene monoalkyl (or alkenyl) ethers or polyoxyethylene polyoxypropylene copolymers are preferred, and polyoxyethylene monoalkyl (or alkenyl) ethers are more preferred.

[0022] Examples of the amphoteric surfactant (b3) include one or more selected from acetate betaines such as lauryl dimethylamino acetate betaine; imidazolinium betaines such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amido alkyl betaines such as coconut oil fatty acid amidopropyl betaine; long-chain alkyl imidazoline betaine salts such as N-alkyl-1-hydroxyethyl imidazoline betaine sodium; and alkylamine oxides. Among these, from the viewpoint of ensuring a comfortable feeling of use, one or more selected from lauryl hydroxysulfobetaine, coconut oil fatty acid amido alkyl betaine, and alkyl sulfobetaine, and alkylamine oxide are preferred, and one or more selected from coconut oil fatty acid amido alkyl betaine and alkylamine oxide are more preferred.

[0023] The content of component (B) (the total content of components (b1), (b2) and (b3)) in the cleanser composition for intraoral instruments of the present invention is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, even more preferably 0.7% by mass or more, and even more preferably 1% by mass or more, from the viewpoint of exerting an excellent denture plaque removing effect. Moreover, the content of component (B) in the cleanser composition for intraoral instruments of the present invention is preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, and even more preferably 8% by mass or less, from the viewpoint of ensuring a comfortable feeling of use when the intraoral instruments are worn after application of the cleanser composition for intraoral instruments of the present invention. The content of component (B) is preferably 0.1 to 20% by mass, more preferably 0.3 to 15% by mass, more preferably 0.7 to 10% by mass, and even more preferably 1 to 8% by mass.

[0024] From the viewpoint of exerting an excellent denture plaque removal effect, the mass ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.05 or more, preferably 0.1 or more, more preferably 0.15 or more, even more preferably 0.25 or more, still more preferably 0.3 or more, and 50 or less, preferably 35 or less, more preferably 20 or less, even more preferably 15 or less, and still more preferably 8 or less. The mass ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.05 or more and 50 or less, preferably 0.1 to 35, more preferably 0.15 to 20, even more preferably 0.25 to 15, and still more preferably 0.3 to 8.

[0025] The cleanser composition for intraoral instruments of the present invention has a content of less than 8 mass% of mono- or dihydric alcohol (C) having from 2 to 6 carbon atoms, or does not contain mono- or dihydric alcohol (C) having from 2 to 6 carbon atoms. By limiting the content of component (C) in this way, it is possible to effectively exert an excellent denture plaque removal effect, while ensuring a comfortable feel when wearing an intraoral instrument after applying the cleanser composition for intraoral instruments of the present invention.

[0026] Specific examples of the component (C) include ethanol, propanol, butanol, isopropanol, propylene glycol, butylene glycol, dipropylene glycol, and ethylene glycol.

[0027] From the viewpoint of ensuring a comfortable feel while achieving an excellent denture plaque removal effect, the content of component (C) in the cleanser composition for intraoral instruments of the present invention is less than 8 mass%, preferably less than 7 mass%, more preferably less than 5 mass%, even more preferably less than 4 mass%, even more preferably less than 2 mass%, even more preferably less than 1 mass%, and even more preferably less than 0.5 mass%, or it is preferable that the cleanser composition for intraoral instruments of the present invention does not contain component (C).

[0028] The cleansing composition for intraoral instruments of the present invention may further contain a pH adjuster (D), which makes it possible to maintain an effective pH for enhancing the immediate effect of removing denture plaque. Specific examples of component (D) include one or more selected from carbonates and bicarbonates, potassium hydroxide and sodium hydroxide, and organic acids such as citric acid, malic acid, lactic acid, tartaric acid, and succinic acid, or salts thereof. Among these, one or more selected from carbonates and bicarbonates are preferred, and one or more selected from sodium carbonate, sodium hydrogencarbonate, and sodium sesquicarbonate are more preferred. In this case, from the viewpoint of stabilizing the pH of the cleanser composition for intraoral instruments of the present invention, the content of the pH adjuster in the cleanser composition for intraoral instruments of the present invention is preferably 0.1 to 60 mass%, more preferably 0.15 to 20 mass%, even more preferably 0.2 to 10 mass%, even more preferably 0.6 to 5 mass%, even more preferably 0.6 to 1.4 mass%, even more preferably 0.6 to 1 mass%, and even more preferably 0.6 to 0.8 mass%.

[0029] The cleansing composition for intraoral instruments of the present invention may further contain a chelating agent, which can further exert the effect of removing stains from intraoral instruments. The chelating agent is preferably one or more selected from phosphoric acid, phosphonic acid, aminocarboxylic acid, organic acid, and salts thereof. Specific examples of phosphoric acid or a salt thereof include pyrophosphoric acid or a salt thereof, tripolyphosphoric acid or a salt thereof, metaphosphoric acid or a salt thereof, and phytic acid or a salt thereof. Specific examples of the phosphonic acid or a salt thereof include hydroxyethanediphosphonic acid or a salt thereof, aminotrimethylenephosphonic acid or a salt thereof, ethylenediaminetetramethylenephosphonic acid or a salt thereof, and phosphonobutanetricarboxylic acid or a salt thereof. Specific examples of aminocarboxylic acids or salts thereof include edetic acid (EDTA) or a salt thereof, nitrilotriacetic acid (NTA) or a salt thereof, hydroxyethyliminodiacetic acid (HIDA) or a salt thereof, tetrasodium 3-hydroxy-2,2'-iminodisuccinate (HIDS) or a salt thereof, diethylenetriaminepentaacetic acid (DPTA) or a salt thereof, hydroxyethylethylenediaminetriacetic acid (HEDTA) or a salt thereof, dihydroxyethylglycine (DHEG) or a salt thereof, L-glutamic acid diacetate (GLDA) or a salt thereof, and methylglycine diacetate (MGDA) or a salt thereof. Specific examples of organic acids or salts thereof include citric acid or its salts, malic acid or its salts, tartaric acid or its salts, gluconic acid or its salts, oxalic acid or its salts, maleic acid or its salts, malonic acid or its salts, succinic acid or its salts, aspartic acid or its salts, and glutamic acid or its salts.

[0030] In this case, from the viewpoint of stain removal effect, the content of the chelating agent in the cleanser composition for intraoral instruments of the present invention is preferably 0.01 to 50 mass%, more preferably 0.03 to 40 mass%, even more preferably 0.05 to 30 mass%, and even more preferably 0.07 to 25 mass%.

[0031] The cleanser composition for intraoral instruments of the present invention preferably contains water, which allows the above-mentioned components to be dispersed or dissolved well while promoting the interaction between components (A) and (B) on denture plaque, and also enhances the diffusibility of the cleanser composition for intraoral instruments after application to the intraoral instruments, thereby providing an excellent denture plaque removal effect.

[0032] The water content in the cleanser composition for intra-oral instruments of the present invention is preferably 10% by mass or more, more preferably 30% by mass or more, even more preferably 50% by mass or more, even more preferably 70% by mass or more, even more preferably 90% by mass or more, preferably 99.9% by mass or less, more preferably 99.5% by mass or less, and even more preferably 99% by mass or less. In the present invention, water means the total water contained in the cleanser composition for intraoral instruments, including not only purified water etc. directly blended in the cleanser composition for intraoral instruments, but also the water contained in each of the blended components. The water content can be measured by calculation from the amount of water added and the amount of water in the added components, but can also be measured, for example, with a Karl Fischer moisture meter.

[0033] The cleanser composition for intra-oral instruments of the present invention may contain, in addition to the above-mentioned components, for example, anti-inflammatory agents, preservatives, fragrances, pigments, colorants, etc., within the scope of not impairing the effects of the present invention.

[0034] The pH of the cleanser composition for intra-oral instruments of the present invention at 25°C is, from the viewpoint of effectively enhancing the rapid action of the denture plaque removal effect, preferably 7 or more, more preferably 8.8 or more, even more preferably 9 or more, still more preferably 9.5 or more, and is preferably 14 or less, more preferably 13 or less, even more preferably 12 or less, and still more preferably 11 or less.

[0035] The cleanser composition for intra-oral instruments of the present invention may be in the form of a liquid, foam, paste, gel, powder, granules, or tablet, and may also be in the form of a sheet impregnated with the liquid cleanser composition for intra-oral instruments of the present invention, or in the form of a spray container, a foam container, or an aerosol container. When the cleanser composition for intraoral instruments of the present invention is used to clean intraoral instruments, in the case of a powder, granule, or tablet form, it may be diluted with water or the like or dissolved in water or the like before use as a cleanser for intraoral instruments. In this case, it is sufficient that the cleanser composition for intraoral instruments at the time of application to the cleanser for intraoral instruments has a formulation that satisfies the specified requirements.

[0036] In particular, the cleansing composition for intraoral instruments of the present invention is preferably in the form of a foam, and by coating intraoral instruments with the foam, it is possible to effectively exert an excellent effect of removing denture plaque and an effect of inhibiting its formation. In particular, by forming the composition in a foam form and coating the intraoral appliance with this, the cleanser composition can sufficiently reach every corner of the intraoral appliance having a complex shape, and can effectively and efficiently exert excellent denture plaque removal and formation inhibition effects. As a result, by simply rinsing the intraoral appliance after application of the composition with water or the like, it is possible to exert a highly rapid and excellent denture plaque removal and formation inhibition effect without the need for any additional physical force such as brushing.

[0037] Specifically, the method for cleaning an intraoral appliance using the cleanser composition for intraoral appliances of the present invention involves first immersing a used intraoral appliance such as a denture in the cleanser composition for intraoral appliances, or applying the cleanser composition to the intraoral appliance by foaming, applying, dropping or spraying, etc., and then leaving the appliance for a certain period of time. The leaving time is usually 3 to 30 minutes, preferably 4 to 20 minutes, and more preferably 5 to 10 minutes. Next, the intraoral appliance after being left standing is rinsed with water or the like to wash away the cleanser composition for intraoral appliances. In the case of the cleanser composition for intraoral appliances of the present invention, more preferably, it is sufficient to simply rinse away the cleanser composition, and there is no need to apply any additional physical force such as brushing.

[0038] When the cleanser composition for intraoral instruments of the present invention is in the form of a foam, it is used by covering an intraoral instrument such as a denture with the foamed cleanser composition for intraoral instruments and then leaving it for a certain period of time. The time for covering the intraoral appliance with the foam is preferably 1 minute or more, more preferably 2 minutes or more, and even more preferably 3 minutes or more, from the viewpoint of fully enjoying the excellent denture plaque removal effect and formation inhibitory effect. Also, the time for covering the intraoral appliance with the foam is preferably 30 minutes or less, more preferably 20 minutes or less, and even more preferably 10 minutes or less, from the viewpoint of fully exerting the effect of the foam. And the time for covering the intraoral appliance with the foam is preferably 1 minute or more and 30 minutes or less, more preferably 2 to 20 minutes, and even more preferably 3 to 10 minutes.

[0039] The amount of foam covering the intraoral appliance should be 1 cm2 or less of the surface area of ​​the intraoral appliance in order to fully utilize the foam's effects and fully enjoy its excellent denture plaque removal and formation inhibition effects. 2 It is preferably 0.05 g or more, more preferably 0.07 g or more, even more preferably 0.1 g or more, and preferably 3.5 g or less, more preferably 3.2 g or less, even more preferably 3 g or less, per unit weight.

[0040] After the intraoral appliance is covered with the formed foam, it is preferable to rinse the intraoral appliance with water to wash away the cleaner composition. When the cleaner composition for intraoral appliances of the present invention is in the form of a foam, it is possible to exert a highly rapid and excellent effect of removing denture plaque and inhibiting its formation while washing away the covering foam simply by rinsing the intraoral appliance with water without requiring any particular physical force, which reduces the burden on users such as elderly people and makes it easy to increase the frequency of use. In addition, after the foam is formed and the intraoral appliance is covered, it is preferable to rinse the intraoral appliance with water after the composition is applied without applying any additional physical force, which makes it possible to clean the intraoral appliance simply and effectively.

[0041] In order to fully exert the foaming effect, it is preferable to fill the cleanser composition for intra-oral instruments of the present invention into a container equipped with a foam-forming mechanism and form foam by spraying or ejecting from the container. A container equipped with a foam-forming mechanism is a container that can form foam by spraying or discharging the contents filled in the container from a spray or discharge port to the outside of the container via the foam-forming mechanism. Examples of containers equipped with such a foam-forming mechanism include trigger-type spray containers and pump-type dispenser containers.

[0042] A trigger-type spray container has a container body in which the contents are filled, and a trigger and a sprayer which are foam-forming mechanisms, and when the trigger is pulled during use, the contents are sprayed to the outside from the nozzle of the sprayer to form foam. Such a trigger-type spray container may be of a direct pressure type or a pressure-accumulation type. A pump-type dispenser container comprises a container body into which the contents are filled, a tube or nozzle, and a foam-forming mechanism such as a mesh inside these. When using the container, by pressing part of it, the contents are ejected from the outlet of the tube or nozzle to the outside, forming a foam. When the cleansing composition for intraoral instruments of the present invention is used to clean intraoral instruments, it is preferable to use a trigger-type spray container among these containers, from the viewpoint of fully exerting the foam effect.

[0043] When using a trigger-type spray container, in order to fully utilize the foam effect, it is desirable to set the spray diameter at a spray distance of 20 cm to preferably 2 cm or more, more preferably 3 cm or more, preferably 10 cm or less, and more preferably 8 cm or less. In addition, in terms of effectively forming foam, it is desirable to set the spray force of the cleaner composition contained in a trigger-type spray container to preferably 1 g f or more, more preferably 3 g f or more, and preferably 10 g f or less, more preferably 8 g f or less at a spray distance of 20 cm.

[0044] In this way, the cleanser composition for intra-oral appliances of the present invention can sufficiently remove denture plaque from intra-oral appliances with a short application time without the need for any particular additional physical force, thereby reducing the burden on users such as elderly people and making it easy to increase the frequency of use.

[0045] In relation to the above-mentioned embodiment, the present invention further discloses the following cleansing composition for intraoral instruments and a method for cleaning intraoral instruments using the same. [1] The following components (A) and (B): (A) 0.05% by mass or more and 8% by mass or less of an anionic homopolymer or copolymer having a mass average molecular weight of 2,000 or more and 500,000 or less, which contains a structural unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphate group (B) One or more surfactants selected from anionic surfactants, nonionic surfactants, and amphoteric surfactants Contains The mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.05 or more and 50 or less, and A cleansing agent composition for intra-oral instruments, comprising a monohydric or dihydric alcohol (C) having from 2 to 6 carbon atoms in an amount of less than 8 mass %. [2] The above-mentioned cleanser composition for intra-oral instruments [1], wherein the anionic monomer (a1) constituting component (A) is one or more selected from acrylic acid, methacrylic acid, itaconic acid, maleic acid, fumaric acid, sulfonic acid, styrenesulfonic acid, methacryloyloxyalkylsulfonic acid, methacrylamidealkylsulfonic acid, acryloyloxyalkylphosphate, and anhydrides thereof, monomers in which a portion of the monomer is substituted with an alkyl group or the like, and sugar-derived monomers such as glycopyranose in which a carboxymethyl group is bonded to a portion of the hydroxyl group, and is preferably one or more selected from acrylic acid, methacrylic acid, maleic acid, and sulfonic acid. [3] A cleanser composition for intra-oral instruments according to the above [1] or [2], wherein the content of structural units derived from anionic monomer (a1) in 100% by mass of all structural units of component (A) is preferably 15% by mass or more, more preferably 35% by mass or more, even more preferably 50% by mass or more, and preferably 100% by mass or less. [4] The cleanser composition for intraoral instruments according to any one of the above [1] to [3], wherein component (A) is one or more selected from acrylic acid homopolymer, methacrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, acrylic acid / sulfonic acid copolymer, vinyl acetate / maleic acid copolymer, phosphinic acid / acrylic acid copolymer, and carboxymethylcellulose, preferably one or more selected from acrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, and acrylic acid / sulfonic acid copolymer, more preferably one or more selected from acrylic acid / maleic acid copolymer and acrylic acid / sulfonic acid copolymer, even more preferably acrylic acid / maleic acid copolymer. [5] The cleanser composition for intra-oral instruments according to any one of the above [1] to [4], wherein the content of component (A) is preferably 0.07% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, still more preferably 0.3% by mass or more, and preferably 7% by mass or less, more preferably 6% by mass or less, even more preferably 5% by mass or less, and still more preferably 4% by mass or less.

[0046] [6] The cleanser composition for intra-oral instruments according to any one of the above [1] to [5], wherein the anionic surfactant (b1) preferably has a mass average molecular weight of less than 2,000. [7] The cleanser composition for intra-oral instruments according to any one of the above [1] to [6], wherein the nonionic surfactant (b2) is preferably a polyoxyethylene monoalkyl (or alkenyl) ether or a polyoxyethylene polyoxypropylene copolymer, more preferably a polyoxyethylene monoalkyl (or alkenyl) ether. [8] The cleanser composition for intra-oral instruments according to any one of the above [1] to [7], wherein the amphoteric surfactant (b3) is preferably one or more selected from lauryl hydroxysulfobetaine, coconut oil fatty acid amido alkyl betaine, alkyl sulfobetaine, and alkylamine oxide, and more preferably one or more selected from coconut oil fatty acid amido alkyl betaine and alkylamine oxide. [9] The cleanser composition for intra-oral instruments according to any one of the above [1] to [8], wherein the content of component (B) (the total content of components (b1), (b2) and (b3)) is preferably 0.1 mass% or more, more preferably 0.3 mass% or more, even more preferably 0.7 mass% or more, still more preferably 1 mass% or more, and preferably 20 mass% or less, more preferably 15 mass% or less, even more preferably 10 mass% or less, and still more preferably 8 mass% or less.

[10] The cleanser composition for intra-oral instruments according to any one of the above [1] to [9], wherein the mass ratio of the content of component (A) to the content of component (B) ((A) / (B)) is preferably 0.1 or more, more preferably 0.15 or more, even more preferably 0.25 or more, still more preferably 0.3 or more, and preferably 35 or less, more preferably 20 or less, even more preferably 15 or less, and still more preferably 8 or less.

[0047]

[11] The content of component (C) is preferably less than 7 mass%, more preferably less than 5 mass%, even more preferably less than 4 mass%, even more preferably less than 2 mass%, even more preferably less than 1 mass%, and even more preferably less than 0.5 mass%, or the cleanser composition for intra-oral instruments of the present invention is any one of the cleanser compositions for intra-oral instruments according to [1] to

[10] above which does not contain component (C).

[12] The cleanser composition for intra-oral instruments according to any one of the above [1] to

[11] , wherein the content of the pH adjuster (D) is preferably 0.1 to 60 mass%, more preferably 0.15 to 20 mass%, even more preferably 0.2 to 10 mass%, still more preferably 0.6 to 5 mass%, still more preferably 0.6 to 1.4 mass%, still more preferably 0.6 to 1 mass%, and still more preferably 0.6 to 0.8 mass%.

[13] The cleanser composition for intra-oral instruments according to any one of the above [1] to

[12] , wherein the water content is preferably 10% by mass or more, more preferably 30% by mass or more, even more preferably 50% by mass or more, even more preferably 70% by mass or more, even more preferably 90% by mass or more, and preferably 99.9% by mass or less, more preferably 99.5% by mass or less, and even more preferably 99% by mass or less.

[14] The cleanser composition for intra-oral instruments according to any one of the above [1] to

[13] , having a pH at 25°C of preferably 7 or more, more preferably 8.8 or more, even more preferably 9 or more, still more preferably 9.5 or more, and preferably 14 or less, more preferably 13 or less, even more preferably 12 or less, and still more preferably 11 or less.

[0048]

[15] The following components (A) and (B): (A) 0.05% by mass or more and 8% by mass or less of an anionic homopolymer or copolymer having a mass average molecular weight of 2,000 or more and 500,000 or less, which contains a structural unit derived from an anionic monomer (a1) having a carboxyl group, a sulfo group, or a phosphate group (B) One or more surfactants selected from anionic surfactants, nonionic surfactants, and amphoteric surfactants Contains The mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.05 or more and 50 or less, and A cleansing agent composition for intraoral instruments, the content of a monohydric or dihydric alcohol (C) having 2 to 6 carbon atoms being less than 8 mass%, A method for cleaning an intraoral appliance, comprising applying the cleaning agent to the intraoral appliance, leaving it for 3 to 30 minutes, and then rinsing with water.

[16] The method for cleaning an intraoral appliance according to the above

[15] , wherein the leaving time is preferably 4 to 20 minutes, and more preferably 5 to 10 minutes.

[17] A method for using a cleanser composition for intraoral instruments, comprising applying the cleanser composition for intraoral instruments according to any one of [1] to

[14] above to an intraoral instrument, leaving it to stand, and then rinsing it off.

[18] A method for using the intraoral instrument cleanser composition according to

[17] above, wherein the time for applying the intraoral instrument cleanser composition to the intraoral instrument is from 1 minute to 30 minutes.

[19] A method for using the cleanser composition for intraoral instruments according to

[17] or

[18] above, which comprises applying the cleanser composition to an intraoral instrument and then rinsing the intraoral instrument with water.

[20] Use of any one of the compositions [1] to

[14] above as a cleansing composition for intraoral instruments.

[21] The use according to

[20] above, wherein the composition is applied to an intraoral appliance, left to stand, and then rinsed off with water.

[22] The use of

[20] or

[21] above, wherein the time for applying the composition to the intraoral appliance is from 1 minute to 30 minutes.

[23] Use of any one of the above items

[20] to

[22] , comprising applying the composition to the intraoral appliance and then rinsing the intraoral appliance with water. EXAMPLES

[0049] The present invention will now be described in detail with reference to the following examples. In the tables, the content of each component is expressed as mass % unless otherwise specified.

[0050] [Examples 1 to 20, Comparative Examples 1 to 3] Each cleanser composition for intraoral instruments was prepared by mixing the components shown in Tables 1 and 2. The obtained cleanser compositions for intraoral instruments were evaluated according to the following methods. The results are shown in Tables 1 and 2. The detergent composition for intraoral instruments obtained in Example 1 was filled into a foam-discharging container (a trigger-type spray container set to a spray diameter of 5 cm and a spray force of 5 g·f at a spray distance of 20 cm), and discharged in foam form from the nozzle and applied to a used denture. After leaving it for 5 minutes, the detergent composition for intraoral instruments was rinsed with water. As a result, when the denture cleaned with the detergent composition for intraoral instruments of the present invention was returned to the mouth, denture plaque on the intraoral instruments was sufficiently removed in a short period of time, despite no particular additional physical force such as brushing being applied, and a high level of cleaning performance without slime could be felt.

[0051] <Evaluation of denture plaque removal effect> 1) Preparation of denture plaque model 1)-1 Preparation of denture plaque model test solution Glycerol stocks of Streptococcus mutans JCM5705 and Candida albicans JCM1542 were streaked on an agar plate (Anaero Columbia Agar with RSB, Nippon Becton Dickinson), which was then stored in a plastic case with a CO2 pack under anaerobic conditions and cultured at 37°C for 48 to 72 hours. After culture, a single colony was picked up from the agar plate and placed in a cell culture flask containing 20 ml of liquid medium A (SCD medium Daigo (Nihon Seiyaku Co., Ltd.) 3 wt%, Bacto Yeast Extract (Becton Dickinson Co., Ltd.) 0.5 wt%), and mixed. The resulting mixture was then stored in a plastic case with a CO2 pack under anaerobic conditions and cultured at 37°C for 24 hours. After culturing, the culture solution was diluted with liquid medium A to OD = 0.5. This diluted solution was diluted with liquid medium B (SCD medium Daigo 3 wt%, Bacto Yeast Extract 0.5 wt%, D(+)-glucose (Fuji Film Wako Pure Chemical Industries, Ltd.) 1 wt%, sucrose (Fuji Film Wako Pure Chemical Industries, Ltd.) 2 wt%) to S. mutans OD = 0.01 and C. albicans OD = 0.00001. Further, a sterilized calcium chloride (Fuji Film Wako Pure Chemical Industries, Ltd.) aqueous solution was mixed to a calcium ion final concentration of 40 ppm to prepare a denture plaque model test solution. 1)-2 Preparation of denture plaque model A denture base plate (manufactured by Kyoyu Co., Ltd., material: polymethyl methacrylate resin, 1 cm) was placed in a 24-well plate and 1 mL of the denture plaque model test liquid prepared in 1)-1 above was added to each well. This was then stored in a plastic case together with a CO2 pack under anaerobic conditions and cultured at 37°C for 16 hours.

[0052] 2) Evaluation of denture plaque removal effect The above-mentioned denture plaque model test liquid in the plate was sucked up using a vacuum pump, 1 mL of ion-exchanged water was added, and the plate was shaken for 5 minutes. Next, the ion-exchanged water was sucked up using a pump, and 1 mL of each composition obtained in the Examples and Comparative Examples was prepared separately in a 24-well plate. Next, the denture substrate on which the denture plaque model was formed was immersed in the prepared solution, applied, and left to stand for 5 minutes. Shaking was performed using a shaker (BioShake iQ (Wakembie Tech Co., Ltd.)) at room temperature (25°C) and 550 rpm. Then, each composition was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. The operation of adding 1 mL of ion-exchanged water and shaking for 5 minutes was repeated three times in total. Next, the ion-exchanged water was sucked up, and 750 μL of a 0.1% by mass crystal violet (CV) solution was added, and the mixture was shaken for 15 minutes. The CV staining solution was then sucked up using a pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. This operation of adding 1 mL of ion-exchanged water and shaking for 5 minutes was repeated twice. Next, the ion-exchanged water was sucked up using a pump, 500 μL of ethanol was added, and the mixture was pipetted. The extract was then diluted 10-fold with ion-exchanged water, and the absorbance OD was measured using a microplate recorder (TECAN, wavelength-variable absorbance microplate reader, Sunrise Rainbow Thermo). 595nm was measured. In addition, the absorbance OD when ion-exchanged water was used instead of the above obtained composition was 595nm The denture plaque removal rate (%) was calculated using the initial value as the standard according to the following formula. The higher the denture plaque removal rate obtained, the higher the denture plaque removal effect. Denture plaque removal rate (%) = 100 - {OD when using the above obtained composition 595nm / OD when ion-exchanged water was used instead of the above obtained composition 595nm}×100

[0053] [Table 1]

[0054] [Table 2]

[0055] The components shown in Tables 1 and 2 are as follows. (A) Ingredients and others Acrylic acid / maleic acid copolymer, weight average molecular weight 2000 (Kao Corporation, Poise 521) Acrylic acid / maleic acid = 44 / 56 Acrylic acid / maleic acid copolymer, weight average molecular weight 21000 (Kao Corporation, Poise 520) Acrylic acid / maleic acid = 70 / 30 Acrylic acid / maleic acid copolymer, weight average molecular weight 70,000 (BASF, Sokalan CP45) Acrylic acid / maleic acid = 70 / 30 Acrylic acid sulfonic acid copolymer, weight average molecular weight 5000 (Nippon Shokubai, AQUALIC GL-386) Acrylic acid sulfonic acid copolymer, weight average molecular weight 20,000 (Nippon Shokubai, AQUALIC GH-004) Acrylic acid homopolymer, mass average molecular weight 9000 (Kao Corporation, Oligomer D) Acrylic acid homopolymer, mass average molecular weight 2,500,000 (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., sodium polyacrylate) Polyethylene glycol (Fujifilm Wako Pure Chemical Industries, Ltd., polyethylene glycol 20,000)

[0056] (B) Component Sodium oleate (Tokyo Chemical Industry Co., Ltd.) Sodium laurate (Tokyo Chemical Industry Co., Ltd.) Sodium dodecyl sulfate (Sigma-Aldrich) Sodium α-olefin sulfonate (Liporan LB-440, manufactured by Lion Specialty Chemicals) Polyoxyethylene alkyl ether (Nippon Shokubai, Softanol 70) Cocoyl betaine (TEGO BETAIN CK KB 5S, manufactured by Evonik Nutrition & Care GmbH) Alkylamine oxide (Kao Corporation, Amphitol 20N)

[0057] Formulation examples of the cleansing composition for intraoral instruments of the present invention are shown below. In addition, "molecular weight" in the formulation examples means "weight average molecular weight".

[0058] [Prescription Example 1] TIFF0007641246000003.tif99170

[0059] [Prescription Example 2] TIFF0007641246000004.tif98170

[0060] [Prescription Example 3] TIFF0007641246000005.tif100170

[0061] [Prescription Example 4] TIFF0007641246000006.tif100170

[0062] [Prescription Example 5] TIFF0007641246000007.tif88170

[0063] [Prescription Example 6] TIFF0007641246000008.tif94170

[0064] [Formulation Example 7] TIFF0007641246000009.tif103170

[0065] [Prescription Example 8] TIFF0007641246000010.tif107170

[0066] [Prescription Example 9] TIFF0007641246000011.tif95170

[0067] [Prescription Example 10] TIFF0007641246000012.tif94170

[0068] [Prescription Example 11] The above ingredients were thoroughly mixed, and 3 g of the mixture was compressed into tablets using a tablet press. One tablet was dissolved in 150 mL of water and used.

[0069] [Prescription Example 12] The above ingredients were thoroughly mixed, and 3 g of the mixture was compressed into tablets using a tablet press. One tablet was dissolved in 150 mL of water and used.

[0070] [Prescription Example 13] The above ingredients were thoroughly mixed to prepare a powder. 3 g of the powder was dissolved in 150 mL of water and used.

[0071] [Prescription Example 14] TIFF0007641246000016.tif109170

Claims

1. The following components (A) and (B): (A) 0.2% by mass or more and 4% by mass or less of an anionic homopolymer or copolymer having a mass average molecular weight of 2,000 or more and 500,000 or less, which contains a structural unit derived from an anionic monomer (a1) having one or more kinds selected from acrylic acid, methacrylic acid, maleic acid, and sulfonic acid. (B) One or more surfactants selected from oleate salts and polyoxyethylene alkyl ethers Contains The mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.05 or more and 50 or less, and A cleansing agent composition for intraoral instruments, comprising a monohydric or dihydric alcohol (C) having 2 to 6 carbon atoms in an amount of less than 8% by mass, and an ethanol and dipropylene glycol amount of less than 2% by mass.

2. 2. The cleansing composition for intraoral instruments according to claim 1, having a pH of 7 or more and 14 or less at 25°C.

3. The cleansing composition for intraoral instruments according to claim 1 or 2, further comprising a pH adjuster (D).

4. 4. The cleansing composition for intra-oral instruments according to claim 3, wherein the content of component (D) is 0.1% by mass or more and 60% by mass or less.

5. The cleansing agent composition for intraoral instruments according to any one of claims 1 to 4, wherein the content of component (B) is 0.1% by mass or more and 20% by mass or less.

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