Manufacturing method of protrusion holder and manufacturing device of protrusion holder

Abstract

To provide a projection-bearing body manufacturing method and a projection-bearing body manufacturing device capable of smoothly drawing out projections from recesses.SOLUTION: Provided is a device that executes a projection-bearing body manufacturing method for manufacturing projection-bearing bodies CB having projections CV formed thereon, comprising: material supporting means 20 for executing a material supporting step of supporting a base material BM containing a plastic material by using a supporting member 22 having a supporting surface 22A in which recesses 22B corresponding to projections CV are formed; and pressing means 30 for executing a pressing step of forming the projections CV for forming a projection-bearing body CB from a plastic material PM by pressing the base material BM in a direction of facing the supporting surface 22A to fill the recesses 22B with the plastic material PM. The supporting member 22 is configured from a curvable member and is provided with opening expansion means 90 for executing an opening expansion step of expanding the distance between openings 22C of the recesses 22B by curving the supporting member 22.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a method and an apparatus for manufacturing a protrusion holder. [Background technology]

[0002] Techniques for producing a projection holder having needle-like projections formed thereon are known (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-170795 A Summary of the Invention [Problem to be solved by the invention]

[0004] In the manufacturing technique for the protrusion holder disclosed in Patent Document 1, after a thermoplastic resin 3 (plastic material) is pressed against an intaglio 2 (support member) to form a microneedle (protrusion holder), if the protrusion 11 (protrusion) cannot be smoothly removed from the recess of the support member when separating the protrusion holder from the support member, the protrusion will bend or damaged, making it impossible to form a protrusion holder of the desired shape. This causes the following inconvenience.

[0005] An object of the present invention is to provide a method and an apparatus for manufacturing a protrusion holder that enables a protrusion to be smoothly removed from a recess. [Means for solving the problem]

[0006] The present invention employs the configurations set forth in the claims. Effect of the Invention

[0007] According to the present invention, the support member is curved to widen the opening interval of the recess, so that the protrusion can be smoothly removed from the recess. [Brief description of the drawings]

[0008] [Figure 1] 1A to 1F are explanatory views of a manufacturing apparatus for a protrusion-retaining body according to one embodiment of the present invention and an explanatory view of the operation of the same apparatus, and FIGS. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In this embodiment, the X-axis, Y-axis, and Z-axis are mutually orthogonal, the X-axis and Y-axis are axes in a predetermined plane, and the Z-axis is an axis orthogonal to the predetermined plane. Furthermore, in this embodiment, the view from the front direction in FIG. 1 parallel to the Y-axis is used as a reference, and when directions are indicated without specifying the view, "up" is the direction of the Z-axis arrow, "down" is the opposite direction, "left" is the direction of the X-axis arrow, "right" is the opposite direction, "front" is the front direction in FIG. 1 parallel to the Y-axis, and "rear" is the opposite direction. Note that all of FIG. 1(B)-(H) and (J), which do not include arrows indicating directions, are views viewed from the same direction as FIG. 1(A).

[0010] The manufacturing apparatus for a protrusion holder of the present invention (hereinafter, also simply referred to as the "manufacturing apparatus") EA is an apparatus for carrying out a manufacturing method for a protrusion holder CB on which a protrusion portion CV is formed, and includes material transport means 10 for carrying out a material transport step of transporting a base material BM containing a plastic material PM, material support means 20 for carrying out a material support step of supporting the base material BM with a support member 22 having a support surface 22A on which recesses 22B corresponding to the protrusion portions CV are formed, pressing means 30 for carrying out a pressing step of pressing the base material BM in a direction toward the support surface 22A to fill the recesses 22B with the plastic material PM and form the protrusion portions CV from the plastic material PM to form the protrusion holder CB, and a heating step of heating the plastic material PM. the heating means 40 for applying a heating force to the recess 22B, a positioning means 50 for performing a positioning step for positioning the support sheet BS relative to the support surface 22A, a separating means 60 for performing a separating step for separating the protrusion holder CB from the support member 22, a cooling means 70 for performing a cooling step for cooling the plastic material PM, a leaching means 80 for performing a leaching step for converting the plastic material PM into a porous body by immersing the plastic material PM in water WT as a leaching medium, and an opening expansion means 90 for performing an opening expansion step for bending the support member 22 to widen the opening spacing 22C of the recess 22B (see the enlarged view in Figure 1 (D)), and is located in the vicinity of a base material supply means PS for performing a base material supply step for supplying the base material BM. The base material BM is formed by laminating a plastic material PM on one side of a support sheet BS. The support sheet BS of this embodiment is made of paper as a transparent member having permeability that allows at least one of liquid and gas to pass through. The plastic material PM has thermoplasticity due to its main component being polylactic acid (PLA), and contains polyethylene glycol PG (see the enlarged view of FIG. 1(F)) as a leaching material that leaches into water WT. The plastic material PM of this embodiment is a mixture of two components, polylactic acid and polyethylene glycol PG, with a weight ratio of 5:5.

[0011] The material conveying means 10 is composed of multiple arms and includes a so-called articulated robot 11 as a driving device that can displace what is supported by the tip arm 11A, which is the working part, to any position and any angle within its working range, and a holding plate 12 supported by the tip arm 11A and having a holding surface 12A that can be adsorbed and held by a pressure reduction means (holding means) not shown, such as a pressure reduction pump or vacuum ejector, and is configured to place the base material BM on the supporting member 22 by abutting the plastic material PM against the supporting surface 22A.

[0012] The material support means 20 includes a base 21 having a step 21A formed thereon, and a support member 22 that is fitted into and supported by the step 21A and has a recess 22B formed on a support surface 22A. The support member 22 is made of resin, which is a bendable material.

[0013] The pressing means 30 includes a linear motor 31 as a driving device, and a pressing member 32 supported by an output shaft 31A of the linear motor 31. In this embodiment, the pressing member 32 is made of a transparent material.

[0014] The heating means 40 includes a heating device 41 arranged inside the base 21 and including a coil heater, the heating side of a heat pipe, or the like.

[0015] The positioning means 50 is composed of imaging means such as a camera or a projector, and various sensors such as optical sensors and ultrasonic sensors, and is equipped with a detection device 51 supported on the pressing member 32 via a bracket 51A, an XY table 52 as a driving device, and a rotary motor 53 as a driving device supported on an output base 52A of the XY table 52 and supporting the base 21 with an output shaft 53A, and is configured to move the support member 22 in a straight line or curved direction within the XY plane, and to rotate the support member 22 in the XY plane.

[0016] The separating means 60 is composed of a plurality of arms, and includes a so-called articulated robot 61 as a driving device that can displace what is supported by a distal arm 61A as a working part to any position and any angle within its working range, a bracket 62 supported by the distal arm 61A, a linear motor 63 as a driving device supported by the bracket 62, and a holding plate 64 supported by the output shaft 63A and having a holding surface 64A that can be sucked and held by a decompression means (holding means) (not shown) such as a decompression pump or a vacuum ejector. The holding plate 64 is made of resin, which is an elastically deformable member.

[0017] The cooling means 70 includes a cooling device 71 that is provided inside the holding plate 64 and is made up of a Peltier element, the cooling side of a heat pipe, or the like.

[0018] The brewing means 80 comprises water WT and a container 81 for receiving the water WT.

[0019] The opening widening means 90 includes an articulated robot 61 and a bracket 62 shared with the spacing means 60, a linear motor 91 as a driving device supported by the bracket 62, a suction pad 92 supported by an output shaft 91A of the linear motor 91 via an arm 92A and capable of being sucked and held by a decompression means (holding means) (not shown) such as a decompression pump or a vacuum ejector, and a curved member 93 having a curved surface 93A. The linear motor 91 functions as a tensioning means for carrying out a surface direction tensioning step of applying tension to the supporting member 22 so that the outer edges of the supporting member 22 are separated from each other.

[0020] The operation of the above-mentioned manufacturing apparatus EA for a projection holder will now be described. First, the manufacturing equipment EA in which each member is arranged at the initial position shown by the solid line in Fig. 1(A) is supplied with a base material BM by a user of the manufacturing equipment EA (hereinafter, simply referred to as "user") or a conveying means (not shown), such as an articulated robot or a belt conveyor, on the base material supplying means PS as shown in the figure, and then the user inputs a signal to start automatic operation via an operating means (not shown), such as an operation panel or a personal computer. Then, the material conveying means 10 drives the articulated robot 11 and the pressure reducing means (not shown), moves the holding plate 12 to bring the holding surface 12A into contact with the support sheet BS, and holds the base material BM by suction on the holding surface 12A, and places the base material BM on the support surface 22A of the support member 22 as shown by the two-dot chain line in Fig. 1(A), and then stops driving the pressure reducing means (not shown) to return the holding plate 12 to the initial position. Next, the pressing means 30 drives the linear motor 31 to lower the pressing member 32, and as shown in FIG. 1(B), the pressing member 32 presses the base material BM in the direction toward the support surface 22A, filling the recesses 22B with the plastic material PM. At this time, the heating means 40 drives the heating device 41 to heat and soften the plastic material PM, making it easier to fill the recesses 22B with the plastic material PM. Thereafter, the positioning means 50 drives the detection device 51 to detect the position of the support sheet BS, and based on this detection result, the positioning means 50 drives the XY table 52 and the rotary motor 53 to move the support member 22 so that the recesses 22B (projections CV) are positioned at predetermined positions on the support sheet BS. As a result, the projections CV and the base FD supporting the projections CV are formed from the plastic material PM, and the projection holder CB with the projections CV formed on the support sheet BS is formed. Next, the pressing means 30 drives the linear motor 31 to return the pressing member 32 to the initial position, and then the heating means 40 stops driving the heating device 41 .

[0021] Then, the opening widening means 90 drives the articulated robot 61 and the pressure reducing means (not shown) to move the suction pad 92, and as shown in FIG. 1(C), the suction pad 92 sucks and holds the support member 22, and then, as shown in FIG. 1(D), the support member 22 is pressed against the curved surface 93A of the curved member 93. As a result, the support member 22 is curved, and as shown in the enlarged view of FIG. 1(D), the opening interval 22C of the recess 22B is widened to form a gap CL between the recess 22B and the protrusion CV, making it easier to remove the protrusion CV from the recess 22B. At this time, the opening widening means 90 drives the linear motor 91 to widen the mutual interval between the suction pads 92, and imparts tension to the support member 22 so that the outer edges of the support member 22 are separated from each other, thereby making the opening interval 22C even wider. Next, the separating means 60 and the cooling means 70 drive the linear motor 63 and the cooling device 71, and as shown by the two-dot chain line in FIG. 1(D), the holding plate 64 is brought into contact with the protrusion holder CB, and the plastic material PM is cooled. This causes the plastic material PM to shrink, and the gap CL to further expand. At this time, the separating means 60 pressurizes the plastic material PM with the holding plate 64 while the cooling means 70 cools the plastic material PM, thereby improving the adhesion between the plastic material PM and the support sheet BS. After that, when the cooling means 70 stops driving the cooling device 71 and finishes cooling the plastic material PM, the separating means 60 drives the linear motor 63 and the decompression means (not shown), and after adsorbing and holding the protrusion holder CB with the holding surface 64A, the holding plate 64 is returned to its initial position, and the protrusion CV is removed from the recess 22B, as shown in FIG. 1(E). Next, the separating means 60 drives the articulated robot 61 to return the support member 22 to its initial position, stops driving the pressure reducing means (not shown), and after detaching the suction pad 92 from the support member 22, the protrusion holder CB is immersed in the water WT as shown in Fig. 1(F). As a result, the polyethylene glycol PG contained in the plastic material PM seeps into the water WT, and as shown in the enlarged view of Fig. 1(F), holes HL are formed in the areas where the polyethylene glycol PG was previously present, forming hollow spaces, and the plastic material PM becomes porous.Then, the separating means 60 drives the articulated robot 61 to transport the protrusion holder CB with the hole HL formed therein to the next process not shown, stops driving the pressure reducing means not shown, detaches the holding plate 64 from the protrusion holder CB, and returns the detached holding plate 64 to its initial position, and the same operations as described above are then repeated.

[0022] According to the embodiment as described above, the support member 22 is curved to widen the frontage interval 22C of the recess 22B, so that the protrusion CV can be smoothly removed from the recess 22B.

[0023] The means and steps in the present invention are not limited in any way as long as they can perform the operations, functions, or steps described for those means and steps, and are not limited at all to the components and steps of a single embodiment shown in the above embodiment. For example, the pressing step may be any step that presses the base material in a direction toward the support surface to fill the recesses with a plastic material, and forms protrusions from the plastic material to form a protrusion holder, and is not limited in any way as long as it is within the technical scope in light of the common general technical knowledge at the time of filing (the same applies to other means and steps).

[0024] The material transport means 10 may be configured to transport the base material BM by sharing the articulated robot 61 with the separating means 60 and the opening widening means 90 without adopting the articulated robot 11, or may adopt a suction pad or the like in place of or in combination with the holding plate 12, and may or may not be provided in the protrusion-holding body manufacturing apparatus EA of the present invention.If it is not provided, the base material BM can be transported by other equipment or by hand.

[0025] The material support means 20 may not have a step portion 21A in the base 21, may be provided with a pressure reducing means such as a vacuum pump or a vacuum ejector that holds the support member 22, or a support member holding means such as a chuck motor, or may not have the base 21 and may be composed only of the support member 22. The support member 22 may be any bendable material such as metal, resin, silicone, rubber, wood, paper, etc., the number of recesses 22B may be one or more, and a release-improving material such as fluorine or silicone may be coated, applied or laminated on the support surface 22A or recesses 22B to make it easier to separate the protrusion holder CB from the support member 22.

[0026] The pressing means 30 may move the support member 22 without or while moving the pressing member 32, and may press the base material BM in a direction toward the support surface 22A to form the protrusion CV, the pressing member 32 may be translucent or may not be transparent, the articulated robot 11 and the holding plate 12 may be shared with the material conveying means 10 without adopting the linear motor 31 and the pressing member 32, or the articulated robot 61, the bracket 62, the linear motor 63 and The holding plate 64 may be shared with the spacing means 60, and the base material BM may be pressed in the direction toward the support surface 22A via the holding plate 12 or the holding plate 64 to form the protrusion portion CV, or the articulated robot 11 may be shared with the material conveying means 10 without using the linear motor 31, or the articulated robot 61 may be shared with the spacing means 60 and the opening expansion means 90 instead of the linear motor 31, and the base material BM may be pressed in the direction toward the support surface 22A via the pressing member 32 to form the protrusion portion CV.

[0027] The heating means 40 may be arranged outside the base 21, or inside the support member 22 or inside the pressing member 32, and may heat the plastic material PM before pressing by the pressing means 30, or may heat the plastic material PM while pressing by the pressing means 30, or may heat the plastic material PM after pressing by the pressing means 30, and may or may not be included in the protrusion holder manufacturing apparatus EA of the present invention.

[0028] The positioning means 50 may move at least one of the support member 22 and the pressing member 32 in a straight line or a curved line or may rotate within the XY plane; for example, the support member 22 may move in a straight line or a curved line in the X direction (or Y direction) and the pressing member 32 may move in a straight line or a curved line in the Y direction (X direction); the positioning means 50 may move the support member 22 and the pressing member 32 in a straight line or a curved line in a direction other than the X or Y direction; it may simply move the support member 22 and the pressing member 32 in a straight line or a curved line within the XY plane; or it may simply move the support member 22 and the pressing member 32 in a rotational line within the XY plane. The detection device 51 may be a single unit or two or more units, and may detect the position of the support sheet BS relative to the support surface 22A from the side of the pressing member 32, or the base 21 and the support member 22 may be made of transparent or semi-transparent materials so that the position of the support sheet BS relative to the support surface 22A can be detected by looking through the base 21 and the support member 22, or the detection device 51 may not be supported by the pressing member 32. The positioning means 50 may position the plastic material PM relative to the support surface 22A, or may position both the support sheet BS and the plastic material PM relative to the support surface 22A, and may or may not be provided in the protrusion holder manufacturing apparatus EA of the present invention.

[0029] The separating means 60 may be configured so that the articulated robot 61 or the like is not shared with the opening widening means 90, and the holding plate 64 is moved by a driving device or the like independent of the opening widening means 90 to separate the protrusion holder CB from the support member 22, or the articulated robot 11 may be shared with the material conveying means 10 without adopting the articulated robot 61, and the protrusion holder CB may be separated from the support member 22 by applying a peeling tape to the protrusion holder CB and applying tension to the peeling tape to separate the protrusion holder CB from the support member 22, or a vibrator or a supercharger may be used. Vibration means such as an ultrasonic vibrator may be employed to apply vibration to the protrusion holder CB to make it easier to separate the protrusion holder CB from the support member 22, the protrusion holder CB may be centrifuged, the protrusion holder CB may be immersed in water WT and then moved or vibrated to make it easier to leach the polyethylene glycol PG into the water WT, or the curved support member 22 may be transported to a recovery position (not shown) and a new support member 22 may be transported from a support member stocker (not shown) and the new support member 22 may be fitted into the step 21A of the base 21. This may or may not be provided in the protrusion holder manufacturing apparatus EA of the present invention, and if it is not provided, the protrusion holder CB may be separated from the support member 22 by another device or manually.

[0030] The cooling means 70 may be provided with a cooling device 71 inside or near the pressing member 32, and may cool the plastic material PM while the base material BM is pressed by the pressing member 32, or may cool the plastic material PM without pressing the base material BM. The cooling means 70 may be provided outside the holding plate 64, or may be provided inside the base 21 or the support member 22. The cooling means 70 may be configured to cool the plastic material PM by immersing the plastic material PM in a cooling medium such as a liquid such as water or a mixed liquid, an organic solvent such as ethanol or acetone, or an oil such as mineral oil or chemically synthetic oil, or may be configured to cool the plastic material PM by applying air or cold air to the plastic material PM. The cooling means 70 may be configured to cool the plastic material PM by sharing water WT with the leaching means 80 without adopting a cooling device 71, or may not be provided in the protrusion-holding body manufacturing apparatus EA of the present invention.

[0031] The leaching means 80 may use any leaching medium that can leach the leaching material contained in the base material BM, such as liquids such as water or mixed liquids, organic solvents such as ethanol or acetone, or oils such as mineral oil or chemically synthetic oil, and may move, circulate, vibrate, or stir the leaching medium to make it easier to leach the leaching material into the leaching medium, and may or may not be provided in the protrusion holder manufacturing apparatus EA of the present invention.

[0032] The opening expansion means 90 may adopt a configuration in which the support member 22 is held by a chuck motor, a chuck cylinder, or the like, instead of or in combination with the suction pad 92, or it may not be provided with a planar tension applying means. For example, the curved member 93 may be formed of a sphere or a hemisphere and the curved surface 93A may be spherical, or the curved member 93 may be formed of a cylinder or a semicylinder and the curved surface 93A may be an arcuate surface, or the curved member 93 may be formed of a rod-like or point-like member and the support member 22 may be curved by supporting it by lines or points rather than by supporting it by a surface, or an energy applying means may be adopted that applies energy such as heat or light that makes the support member 22 more likely to deform, taking into consideration the composition, material, etc. of the support member 22, and the energy may be applied to make it easier to widen the opening interval 22C of the recess 22B.

[0033] The base material supply means PS may be a simple table, a belt conveyor, or a self-propelled transport table, etc., and may or may not be provided in the protrusion-retaining body manufacturing apparatus EA of the present invention.

[0034] The protrusion holder manufacturing apparatus EA may form the protrusion portion CV by pressing the base material BM in a direction toward the support surface 22A in a fluid atmosphere, for example, a gas such as an elemental gas or a compound gas, a liquid such as water or a mixed liquid, an organic solvent such as ethanol or acetone, or an oil such as mineral oil or chemically synthetic oil.

[0035] The support sheet BS may be made of any material that is permeable to at least one of liquid and gas, such as cloth, nonwoven fabric, resin, mesh material, wood, etc., as well as metal, resin, silicone material, rubber material, wood, paper, ceramics, etc. with through holes formed therein, or may be made of a material that is not permeable to liquid and gas (i.e., not a permeable material), such as metal, resin, silicone material, rubber material, wood, paper, ceramics, etc.

[0036] The plastic material PM is a material that deforms when energy such as heat or pressure is applied to it and does not return to its original shape. Examples of the plastic material PM include metal, clay, resin, etc. In the case of resin, it can be any material that has plasticity, such as PET, polypropylene, polyethylene, polyvinyl chloride, poly(lactide-co-glycolide) copolymer (PLGA), etc., and it can be made of a single component or multiple components, can be composed only of materials that have plasticity, or can be composed of materials that have plasticity and materials that do not have plasticity, can have no thermoplasticity, can not contain leaching materials, or can contain a thermoplastic resin as a material that has thermoplasticity. The ratio of the plastic material PM to the leaching material may be any ratio other than 5:5, such as 8:2 or 1:9, and the basis for these ratios may be any ratio other than weight ratio, such as mass ratio, volume ratio, molar ratio, etc. The leaching material can be anything that will leach into the leaching medium, such as, for example, sodium chloride, potassium nitrate, alum, polyvinyl alcohol, etc. The base material BM may be composed only of plastic material PM without the support sheet BS, or it may have other materials laminated thereon in addition to the support sheet BS and the plastic material PM, and the amount of plastic material PM may be the same as the capacity of the recess 22B or may be greater than the capacity of the recess 22B. The height of the protrusions CV may be 100 nm to 3 mm, or may be 100 nm or less, or may be 3 mm or more. In particular, when used as a so-called microneedle, the height of the protrusions CV is preferably 100 μm to 1.5 mm. The tip of the protrusion CV may be sharp or blunt, may be rounded, may be arrowhead-shaped, or may be bifurcated or branched into three or more prongs. The shape of the protrusion CV may be a cone, a pyramid, a cylinder, a prism, or a combination thereof.

[0037] The protrusion holder CB may be one in which only the protrusion portion CV is formed from a plastic material PM and supported by a support sheet BS, as shown in Figure 1(G), or one in which the protrusion portion CV and base FD are formed from a plastic material PM and the base FD is embedded (permeated) into the support sheet BS, as shown in Figure 1(H), or one in which the protrusion portion CV and base FD are formed from a plastic material PM and are not supported by the support sheet BS, as shown in Figure 1(J).

[0038] The driving equipment in the above-described embodiments may be electric equipment such as a rotary motor, a linear motor, a single-axis robot, or a multi-joint robot having joints on two or more axes, or an actuator such as an air cylinder, a hydraulic cylinder, a rodless cylinder, or a rotary cylinder, or a direct or indirect combination of these may also be used. In the above-described embodiments, when a pressing means or pressing member such as a pressing roller or a pressing head is used to press an object to be pressed, a roller, a round bar, a blade material, a brush-like member, or a member that blows air or a gas may be used instead of or in combination with the above-described examples. The pressing means may be made of a deformable material such as rubber, resin, sponge, or may be made of an indeformable material such as metal or resin. When a supporting (holding) means or a supporting (holding) member that supports (holds) a supported member (held member) is used, a gripping means such as a mechanical chuck or a chuck cylinder, Coulomb force, adhesive (adhesive sheet, adhesive tape), pressure sensitive adhesive (adhesive sheet, adhesive tape), magnetic force, Bernoulli adsorption, suction adsorption, driving equipment, or the like may be used to support (hold) the supported member. [Explanation of symbols]

[0039] EA… Manufacturing equipment for projection holders 20...Material support means 22...Support member 22A…Support surface 22B…Concave 22C…Frontage spacing 30...Pressing means 80...Leaching means 90…Width expansion means 91... Linear motion motor (surface direction tension applying means) BM…Base material CB…Protrusion holder CV…Protrusion PG…Polyethylene glycol (leaching material) PM…Plastic material WT…Water (leaching medium)

Claims

1. A method for manufacturing a projection holder having a projection formed thereon, comprising the steps of: a material supporting step of supporting a base material including a plastic material with a supporting member having a supporting surface on which recesses corresponding to the protrusions are formed; a pressing step of pressing the base material in a direction toward the support surface to fill the recess with the plastic material and form the protrusion from the plastic material to form the protrusion holder; The support member is made of a bendable member, A frontage expanding step is performed in which the support member is curved to widen the frontage interval of the recess; The plastic material comprises a leaching material that is leached into a leaching medium; A method for manufacturing a protrusion-retaining body, comprising the steps of: immersing said plastic material in said leaching medium after said pressing step; thereby making said plastic material porous; and

2. 2. The method for manufacturing a protrusion holder according to claim 1, wherein the opening widening step includes a planar tension applying step of applying tension to the support members so that the outer edges of the support members are spaced apart from each other.

3. A manufacturing device for a projection holder having a projection formed thereon, a material supporting means for supporting a base material including a plastic material, the base material being a supporting member having a supporting surface on which recesses corresponding to the protrusions are formed; a pressing means for pressing the base material in a direction toward the support surface to fill the recess with the plastic material and form the protrusion from the plastic material to form the protrusion holder; The support member is made of a bendable member, a width expanding means for expanding a width interval of the recess by bending the support member, The plastic material comprises a leaching material that is leached into a leaching medium; a leaching means for immersing said plastic material in said leaching medium after the formation of said protrusion holder, thereby making said plastic material porous;

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