Vascular Model

Abstract

This blood vessel model comprises: a first tube that is hollow and tubular; and a second tube that is hollow and tubular and that covers the outer circumferential surface of the first tube. The acoustic impedance of the first tube is greater than the acoustic impedance of the second tube.

Description

[Technical field]

[0001] The present invention relates to a vascular model. [Background technology]

[0002] Medical devices such as catheters are used for minimally invasive treatment or examination within blood vessels. For example, Patent Documents 1 to 4 disclose biological models and simulated blood vessels that enable surgeons such as doctors to simulate procedures using these medical devices. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2017-146415 A [Patent Document 2] JP 2017-53897 A [Patent Document 3] JP 2010-49071 A [Patent Document 4] JP 2004-275682 A Summary of the Invention [Problem to be solved by the invention]

[0004] In a procedure using a medical device, a blood vessel image (hereinafter also referred to as an "ultrasound image") is acquired using an ultrasound imaging diagnostic device in order to grasp the curved shape of the blood vessel, the state inside the blood vessel, and the position of the medical device inside the blood vessel. Here, the blood vessel wall generally has a three-layer structure consisting of the intima, the media, and the adventitia from the inside to the outside. When an ultrasound image is acquired of an actual human blood vessel, the intima, the media, and the adventitia each appear in a manner that can be distinguished by the naked eye on the ultrasound image. However, the techniques described in Patent Documents 1 and 2 have layers corresponding to the adventitia and the media of the blood vessel, but there is a problem that these layers cannot be distinguished on the ultrasound image. Moreover, the techniques described in Patent Documents 3 and 4 do not take into consideration the provision of layers corresponding to the adventitia and the media of the blood vessel.

[0005] The present invention has been made to solve at least some of the above-mentioned problems, and aims to provide a vascular model that resembles an actual living body in an ultrasound image obtained by an ultrasound imaging diagnostic device. [Means for solving the problem]

[0006] The present invention has been made to solve at least part of the above-mentioned problems, and can be realized in the following forms.

[0007] (1) According to one aspect of the present invention, there is provided a blood vessel model comprising a first tube body having a hollow tubular shape and a second tube body having a hollow tubular shape covering an inner peripheral surface of the first tube body, wherein an acoustic impedance of the first tube body is greater than an acoustic impedance of the second tube body.

[0008] According to this configuration, the blood vessel model includes a first tube body and a second tube body, and the acoustic impedance of the first tube body is greater than the acoustic impedance of the second tube body. Therefore, in an ultrasound image obtained by the ultrasound diagnostic imaging device, the image of the first tube body can be made brighter (whitish) than the image of the second tube body. As a result, a blood vessel model can be provided in which the ultrasound image resembles an actual living body.

[0009] (2) In the blood vessel model of the above embodiment, the first tube body and the second tube body each contain a polymer material and microparticles having an acoustic impedance greater than that of the polymer material, and the microparticle concentration contained in the first tube body may be higher than the microparticle concentration contained in the second tube body. According to this configuration, by making the particle concentration contained in the first tube body higher than the particle concentration contained in the second tube body, the acoustic impedance of the first tube body can be easily made higher than the acoustic impedance of the second tube body.

[0010] (3) In the blood vessel model of the above embodiment, the first tube body and the second tube body each contain a polymer material and microparticles having a higher acoustic impedance than the polymer material, the type of microparticles contained in the first tube body is different from the type of microparticles contained in the second tube body, and the microparticles contained in the first tube body may have a higher hardness than the microparticles contained in the second tube body. According to this configuration, by using particles contained in the first tube body that have a higher hardness than the particles contained in the second tube body, the acoustic impedance of the first tube body can be easily made larger than the acoustic impedance of the second tube body.

[0011] (4) In the blood vessel model of the above embodiment, the particle diameter of the microparticles contained in the first tube body and the particle diameter of the microparticles contained in the second tube body may both be within the range of 0.1 μm or more and 500 μm or less. According to this configuration, the particle diameters of the microparticles contained in the first tube body and the particle diameters of the microparticles contained in the second tube body are both within the range of 0.1 μm or more and 500 μm or less, so that it is easy to disperse the microparticles in the polymer material solution when producing the first and second tube bodies.

[0012] (5) In the blood vessel model of the above embodiment, the first tube body and the second tube body may each be formed of a polymer material, and the acoustic impedance of the polymer material constituting the first tube body may be higher than the acoustic impedance of the polymer material constituting the second tube body. According to this configuration, by making the acoustic impedance of the polymer material constituting the first tube body higher than the acoustic impedance of the polymer material constituting the second tube body, the acoustic impedance of the first tube body can be easily made higher than the acoustic impedance of the second tube body.

[0013] (6) In the blood vessel model of the above aspect, the first tube body and the second tube body may each be formed of a polymer material, and the hardness of the first tube body may be higher than the hardness of the second tube body. According to this configuration, by making the hardness of the first tube body greater than that of the second tube body, the acoustic impedance of the first tube body can be easily made greater than the acoustic impedance of the second tube body.

[0014] (7) The blood vessel model of the above embodiment may further include a third tube body having a hollow tubular shape covering an inner peripheral surface of the second tube body, and the acoustic impedance of the third tube body may be equal to or lower than the acoustic impedance of the first tube body and higher than the acoustic impedance of the second tube body. According to this configuration, since the third tube body is provided with a hollow tube shape covering the inner circumferential surface of the second tube body, the blood vessel model can have a three-layer structure similar to that of an actual human blood vessel. The acoustic impedance of the third tube body is equal to or lower than that of the first tube body and is higher than that of the second tube body. Therefore, in an ultrasound image obtained by the ultrasound imaging diagnostic device, the image of the third tube body can be an image with lower brightness (blackish) than that of the first tube body, or an image equivalent to that of the first tube body. The image of the third tube body can be an image with higher brightness (whitish) than that of the second tube body. As a result, a blood vessel model can be provided in which the ultrasound image is more similar to that of an actual living body.

[0015] The present invention can be realized in various forms, for example, in the form of a vascular model, an organ model that includes the vascular model and imitates an organ such as the heart, liver, or brain, a human body simulation device that includes these vascular models and organ models, and a control method for a human body simulation device. [Brief description of the drawings]

[0016] [Figure 1] FIG. 1 is an explanatory diagram illustrating a schematic configuration of a blood vessel simulation device. [Diagram 2] FIG. 2 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model. [Diagram 3] FIG. 3 is a cross-sectional view of the blood vessel model taken along line AA (FIG. 2). [Figure 4] 1A to 1C are diagrams illustrating a method for creating a blood vessel model. [Diagram 5] 1 is a diagram illustrating an ultrasound image obtained by an ultrasound diagnostic imaging apparatus. [Figure 6] FIG. 11 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model according to a second embodiment. [Figure 7] FIG. 13 is a diagram illustrating a method for changing acoustic impedance. [Figure 8] FIG. 13 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model according to a third embodiment. [Figure 9] FIG. 13 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model according to a fourth embodiment. [Figure 10] FIG. 13 is an explanatory diagram illustrating a schematic configuration of a blood vessel simulation device according to a fifth embodiment. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] First Embodiment FIG. 1 is an explanatory diagram illustrating a schematic configuration of a blood vessel simulation device 100. The blood vessel simulation device 100 of this embodiment is a device used to simulate a procedure for treatment or examination of a blood vessel using a medical device. As the medical device, a general device for minimally invasive treatment or examination, such as a catheter, a delivery guidewire, or a plasma guidewire that cuts biological tissue by streamer discharge, may be used. The blood vessel simulation device 100 includes a blood vessel model 1, an outer tissue model 3, and a circulation pump 9.

[0018] In FIG. 1, the axis passing through the center of the blood vessel model 1 and the outer tissue model 3 is represented by axis O (dotted line). In the following examples, the axis passing through the center of the blood vessel model 1 and the axis passing through the center of the outer tissue model 3 both coincide with axis O. However, the axes passing through the centers of the blood vessel model 1 and the outer tissue model 3 may each be different from axis O. Furthermore, for the sake of convenience of explanation, FIG. 1 and the following figures include some parts in which the relative ratio of the sizes of the respective components is depicted differently from the actual ratio. Also, some parts of the respective components are depicted in an exaggerated manner.

[0019] The blood vessel model 1 is a model simulating a human blood vessel. The blood vessel model 1 has an elongated, generally cylindrical shape with openings 1a and 1b at both ends. An outer tissue model 3 simulating human muscle, fat, skin, etc. is disposed on the outside of the blood vessel model 1 so as to surround at least a portion of the outer circumferential surface of the blood vessel model 1 (in the illustrated example, the central portion excluding both ends of the blood vessel model 1). The outer tissue model 3 is formed of a soft synthetic resin (e.g., polyvinyl alcohol: PVA, silicone, etc.). The circulation pump 9 is, for example, a non-volume type centrifugal pump. The circulation pump 9 is provided in the middle of a flow path connecting the openings 1a and 1b of the blood vessel model 1, and circulates the fluid discharged from the opening 1b and supplies it to the opening 1a.

[0020] FIG. 2 is an explanatory diagram illustrating a cross-sectional configuration of the blood vessel model 1. FIG. 2 illustrates XYZ axes that are mutually orthogonal. The X axis corresponds to the longitudinal direction of the blood vessel model 1, the Y axis corresponds to the height direction of the blood vessel model 1, and the Z axis corresponds to the width direction of the blood vessel model 1. The left side (-X axis direction) of FIG. 2 is called the "tip side" of the blood vessel model 1. When an antegrade approach is adopted, the tip side is the side farther from the insertion site of the medical device (distal side). The right side (+X axis direction) of FIG. 2 is called the "base side" of the blood vessel model 1. When an antegrade approach is adopted, the base side is the side closer to the insertion site of the medical device (proximal side). These points are common to the following FIG. 2.

[0021] 3 is a cross-sectional view taken along line AA (FIG. 2) of the blood vessel model 1. The blood vessel model 1 includes a first tube body 10, a second tube body 20, and a third tube body 30.

[0022] The first tube body 10 is disposed on the outermost side of the blood vessel model 1, and simulates the adventitia of a human blood vessel. The first tube body 10 has a hollow tube shape, specifically, a substantially cylindrical shape. The second tube body 20 is disposed on the inner side of the first tube body 10 and on the outer side of the third tube body 30 of the blood vessel model 1 (in other words, between the first tube body 10 and the third tube body 30). 3 Tube body 30and ) and simulates the tunica media of a human blood vessel. The second tube body 20 is hollow tubular, specifically, approximately cylindrical, like the first tube body 10. The second tube body 20 covers the inner circumferential surface of the first tube body 10, and the inner circumferential surface of the first tube body 10 and the outer circumferential surface of the second tube body 20 are in contact with each other. The third tube body 30 is disposed at the innermost part of the blood vessel model 1 and simulates the tunica intima of a human blood vessel. The third tube body 30 is hollow tubular, specifically, approximately cylindrical, like the first tube body 10. The third tube body 30 covers the inner circumferential surface of the second tube body 20, and the inner circumferential surface of the second tube body 20 and the outer circumferential surface of the third tube body 30 are in contact with each other.

[0023] As shown in Fig. 3, in this embodiment, the thickness T10 of the first tube body 10, the thickness T20 of the second tube body 20, and the thickness T30 of the third tube body 30 are the same. However, the thicknesses T10, T20, and T30 may be different from each other. For example, similar to an actual human blood vessel, the thickness T20 of the second tube body 20 corresponding to the tunica media may be made thicker than the thickness T10 of the first tube body 10 corresponding to the tunica adventitia and the thickness T30 of the third tube body 30 corresponding to the tunica intima. Note that the thicknesses T10, T20, and T30 may be the thicknesses of any portion of the first to third tube bodies 10 to 30 in any cross section.

[0024] The first tube body 10, the second tube body 20, and the third tube body 30 are all formed of a polymeric material containing fine particles. In the first to third tube bodies 10 to 30 of this embodiment, PVA is used as the polymeric material. In the first to third tube bodies 10 to 30 of this embodiment, polymer fine particles are used as the fine particles. Note that, as the fine particles, metal fine particles or glass fine particles may be used in addition to polymer fine particles. As the polymeric material, gelatin, urethane, silicone, etc. may be used in addition to PVA.

[0025] Here, the microparticle concentration A contained in the first tube body 10 is higher than the microparticle concentration B contained in the second tube body 20 and is equal to or higher than the microparticle concentration C contained in the third tube body 30 (A>B, A≧C). Moreover, the microparticle concentration C of the third tube body 30 is higher than the microparticle concentration B of the second tube body 20 (C>B). That is, the microparticle concentrations A, B, and C of the first to third tube bodies 10-30 have the relationship "microparticle concentration A≧microparticle concentration C>microparticle concentration B".

[0026] The particle diameter of the microparticles contained in the first to third tube bodies 10 to 30 is preferably 0.1 μm or more and 500 μm or less. The particle diameter of the microparticles contained in the first to third tube bodies 10 to 30 is more preferably in the range of 20 μm or more and 100 μm or less. If the particle diameter is in the range of 20 μm or more and 100 μm or less, the images of the first to third tube bodies 10 to 30 in the ultrasound image obtained by the ultrasound image diagnostic device can be made to more closely resemble the images of actual human blood vessels. For example, in the case of the first tube body 10, the particle diameter of the microparticles can be the average particle diameter of a plurality of microparticles contained in a predetermined unit area when the first tube body 10 is heated to evaporate the PVA gel and then observed under a microscope. The particle diameters of the second tube body 20 and the third tube body 30 can also be obtained by the same method.

[0027] Acoustic impedance is a numerical representation of the ease of sound propagation, and is expressed as the density of a medium times the speed of sound. Here, polymer microparticles have a higher acoustic impedance than PVA. The microparticle concentrations A, B, and C of the first to third tube bodies 10 to 30 have the above-mentioned relationship. Therefore, the acoustic impedance A of the first tube body 10 is larger than the acoustic impedance B of the second tube body 20 and is equal to or larger than the acoustic impedance C of the third tube body 30 (A>B, A≧C). The acoustic impedance C of the third tube body 30 is also larger than the acoustic impedance B of the second tube body 20 (C>B). That is, the acoustic impedances A, B, and C of the first to third tube bodies 10 to 30 have the relationship "acoustic impedance A≧acoustic impedance C>acoustic impedance B".

[0028] The acoustic impedance of the first to third tube bodies 10-30 can be measured, for example, by a measuring device using a method (surface impedance method) for determining the sound absorption coefficient of a medium by measuring the surface impedance (sound pressure / acoustic particle velocity) of the medium surface. Note that the acoustic impedance is proportional to the reflection intensity. For this reason, the reflection intensity of ultrasonic waves on each surface of the first to third tube bodies 10-30 may be measured, and this reflection intensity may be regarded as the acoustic impedance of the first to third tube bodies 10-30.

[0029] 4 is a diagram for explaining a method for producing the blood vessel model 1. The blood vessel model 1 can be produced, for example, by the following steps a1 to a7. Note that FIG. 4 shows the state of step a6. (a1) Polymer microparticles, the amount of which is adjusted to give a microparticle concentration C, are dispersed in a PVA gel in a container 4 to prepare a solution for the third tube body 30. (a2) After immersing the cylindrical core material 5 in the solution of step a1, it is taken out and dried, and a third tube body 30 is formed around the core material 5. (a3) In a container 4, polymer microparticles are dispersed in a PVA gel in an amount adjusted to give a microparticle concentration B, to prepare a solution for the second tube body 20. (a4) The core material 5 obtained in step a2 is immersed in the solution in step a3, then taken out and dried, and the second tube body 20 is formed around the third tube body 30. (a5) Polymer microparticles, the amount of which is adjusted to give a microparticle concentration A, are dispersed in the PVA gel in the container 4 to prepare a solution 10li for the first tube body 10. (a6) The core material 5 obtained in step a4 is immersed in the solution in step a5, then taken out and dried, to form the first tube body 10 around the second tube body 20. (a7) The core material 5 is removed, and both ends (upper and lower ends in FIG. 4) are cut to obtain the blood vessel model 1.

[0030] FIG. 5 is a diagram for explaining an ultrasonic image obtained by an ultrasonic diagnostic imaging device. The ultrasonic diagnostic imaging device has an ultrasonic sensor that transmits ultrasonic waves toward biological tissues and receives ultrasonic waves (reflected waves) reflected after propagating through the biological tissues, and generates a two-dimensional image (hereinafter also referred to as an "ultrasound image") with gradations of gray according to the intensity of the received reflected waves. The ultrasonic sensor is also called an ultrasonic probe, an ultrasonic transducer, a piezoelectric body, an ultrasonic transmitting / receiving element, or an ultrasonic element. There are two types of ultrasonic diagnostic imaging devices: a device that transmits ultrasonic waves from inside a biological lumen toward the body surface to obtain an ultrasonic image, such as IVUS (IntraVascular UltraSound), and a device that transmits ultrasonic waves from the body surface toward the inside of a biological lumen to obtain an ultrasonic image. FIG. 5(A) shows ultrasonic waves UW transmitted from an ultrasonic diagnostic imaging device such as IVUS, and reflected waves RW from a blood vessel model 1.

[0031] Here, the intensity of the reflected wave is high at the interface where the acoustic impedance changes abruptly. As described above, in the blood vessel model 1 of this embodiment, the acoustic impedances A, B, and C of the first to third tube bodies 10-30 have the relationship of "acoustic impedance A ≧ acoustic impedance C > acoustic impedance B", and the second tube body 20 is sandwiched between the first tube body 10 and the third tube body 30, which have relatively large acoustic impedances. Therefore, in the case of the blood vessel model 1 of this embodiment, as shown in FIG. 5(A), a relatively strong reflected wave RW is generated at each of the interface between the lumen 1L and the third tube body 30, the interface between the third tube body 30 and the second tube body 20, the interface between the second tube body 20 and the first tube body 10, and the interface between the first tube body 10 and the outside.

[0032] Fig. 5(B) shows an example of an ultrasound image IM. As described above, strong reflected waves RW are generated at each interface of the blood vessel model 1, and as a result, the first to third tube bodies 10 to 30 of the blood vessel model 1 are each shown in a layered form in the ultrasound image IM obtained by the ultrasound imaging diagnostic device. In addition, in the ultrasound image IM shown in Fig. 5(B), the images of the first tube body 10 and the third tube body 30, which have relatively large acoustic impedance, are brighter (whitish) than the image of the second tube body 20.

[0033] As described above, the blood vessel model 1 of the first embodiment includes the first tube body 10 and the second tube body 20, and the acoustic impedance A of the first tube body 10 is greater than the acoustic impedance B of the second tube body 20. Therefore, as shown in Fig. 5(B) , in an ultrasound image IM obtained by an ultrasound diagnostic imaging device, the image of the first tube body 10 can be made to have a higher luminance (whitish) than the image of the second tube body 20. As a result, it is possible to provide a blood vessel model 1 in which the ultrasound image IM resembles an actual living body.

[0034] In addition, the blood vessel model 1 of the first embodiment includes the third tube body 30 having a hollow tube shape that covers the inner circumferential surface of the second tube body 20, so that the blood vessel model 1 can have a three-layer structure similar to that of an actual human blood vessel. The acoustic impedance C of the third tube body 30 is equal to or less than the acoustic impedance A of the first tube body 10 and is greater than the acoustic impedance B of the second tube body 20. Therefore, as shown in FIG. 5B, in the ultrasound image IM obtained by the ultrasound imaging diagnostic device, the image of the third tube body 30 can be an image with lower brightness (blackish) than that of the first tube body 10, or an image equivalent to that of the first tube body 10. The image of the third tube body 30 can be an image with higher brightness (whitish) than that of the second tube body 20. As a result, the blood vessel model 1 can be provided with an ultrasound image IM that is more similar to that of an actual living body.

[0035] Furthermore, in the blood vessel model 1 of the first embodiment, by making the microparticle concentration A contained in the first tube body 10 higher than the microparticle concentration B contained in the second tube body 20, the acoustic impedance A of the first tube body 10 can be easily made higher than the acoustic impedance B of the second tube body 20. In addition, since the particle diameters of the microparticles contained in the first tube body 10 and the second tube body 20 are both within the range of 0.1 μm or more and 500 μm or less, it is easy to disperse the microparticles in the polymer material solution when producing the first and second tube bodies.

[0036] <Second embodiment> 6 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model 1A of the second embodiment. The blood vessel simulation device 100A of the second embodiment includes a blood vessel model 1A instead of the blood vessel model 1. The blood vessel model 1A includes a first tube body 10A instead of the first tube body 10, a second tube body 20A instead of the second tube body 20, and a third tube body 30A instead of the third tube body 30 in the configuration described in the first embodiment.

[0037] The first to third tube bodies 10A to 30A have the same shapes and arrangement as in the first embodiment, and have the same magnitude relationship of the acoustic impedances A to C as in the first embodiment, "acoustic impedance A≧acoustic impedance C>acoustic impedance B." However, in the second embodiment, the acoustic impedances A to C of the first to third tube bodies 10A to 30A are changed using a method different from the method described in the first embodiment to achieve the above magnitude relationship.

[0038] Fig. 7 is a diagram illustrating a method for changing the acoustic impedance. The "Example 1" column in Fig. 7 lists the method described in the first embodiment (i.e., a method for changing the acoustic impedances A to C by changing the microparticle concentrations A to C). In the second embodiment, the acoustic impedances A to C of the first to third tube bodies 10A to 30A are changed to achieve the above-mentioned magnitude relationship by any of the methods shown in the "Example 2", "Example 3", and "Example 4" columns. Each will be explained in order below.

[0039] In Example 2, the polymeric materials constituting the first to third tube bodies 10A to 30A are changed. The first tube body 10A uses a polymeric material A (e.g., PVA). The second tube body 20A uses a polymeric material B (e.g., silicon). The third tube body 30A uses a polymeric material C (e.g., PVA). The polymeric materials A, B, and C can be any material such as PVA, gelatin, urethane, or silicon, as long as the acoustic impedance of each material is in the relationship of "polymeric material A≧polymeric material C>polymeric material B". The acoustic impedance can be obtained by the same method as in the first embodiment. As illustrated, the polymeric material A and the polymeric material C may be the same. Furthermore, the first to third tube bodies 10A to 30A may or may not contain fine particles. When fine particles are contained, any material such as polymer fine particles, metal fine particles, or glass fine particles can be used. The amounts of fine particles contained in the first to third tube bodies 10A to 30A may be the same or may be different within a range that does not affect the magnitude relationship of the acoustic impedances A to C.

[0040] According to Example 2, by making the acoustic impedance of the polymer material A constituting the first tube body 10A higher than the acoustic impedance of the polymer material B constituting the second tube body 20A, it is possible to easily make the acoustic impedance A of the first tube body 10A higher than the acoustic impedance B of the second tube body 20A. The same applies to the third tube body 30A.

[0041] In Example 3, the hardness of the first to third tube bodies 10A to 30A is changed. Specifically, "hardness A of the first tube body 10A ≧ hardness C of the third tube body 30A > hardness B of the second tube body 20A". The hardness A, B, and C may be achieved by changing the type of polymer material constituting the first to third tube bodies 10A to 30A. Also, the hardness may be achieved by changing the concentration of the polymer material constituting the first to third tube bodies 10A to 30A. Furthermore, when the first to third tube bodies 10A to 30A are produced (FIG. 4), an additive for changing the hardness may be added to the polymer material. The first to third tube bodies 10A to 30A may contain any fine particles or may not contain fine particles.

[0042] According to Example 3, by making the hardness A of the first tube body 10A higher than the hardness B of the second tube body 20A, it is possible to easily make the acoustic impedance A of the first tube body 10A higher than the acoustic impedance B of the second tube body A. The same applies to the third tube body 30A.

[0043] In Example 4, the types of particles contained in the first to third tube bodies 10A to 30A are changed. The first tube body 10A uses particles A (e.g., metal particles). The second tube body 20A uses particles B (e.g., polymer particles). The third tube body 30A uses particles C (e.g., glass particles). As long as the relationship of the hardness of each particle is "Particle A≧Particle C>Particle B", any particles such as polymer particles, metal particles, or glass particles can be used for particles A, B, and C. When particles A to C are each a single type of particle, the hardness of particles A to C can be a catalog value. For example, when particle A is composed of multiple types of particles, the hardness of particle A can be the average value of the hardness of multiple particles contained in a predetermined unit area. As the polymer material that is the main material of the first to third tube bodies 10A to 30A, any material such as PVA, gelatin, urethane, and silicone can be used. The first to third tube bodies 10A to 30A may be made of the same polymer material or different polymer materials as long as the magnitude relationship between the acoustic impedances A to C is not affected.

[0044] According to Example 4, the fine particles A contained in the first tube body 10A are fine particles having a higher hardness than the fine particles B contained in the second tube body 20A, so that the acoustic impedance A of the first tube body 10A can be easily made larger than the acoustic impedance B of the second tube body 20A. The same applies to the third tube body 30A.

[0045] In this way, the acoustic impedances A to C of the first to third tube bodies 10A to 30A may be changed using a method different from the method described in the first embodiment. Although the methods for changing the acoustic impedances A to C have been exemplified in Examples 2 to 4, it is also possible to change the acoustic impedances A to C of the first to third tube bodies 10A to 30A using a method other than those described above. With such a blood vessel model 1A of the second embodiment, it is possible to achieve the same effects as those of the first embodiment described above.

[0046] <Third embodiment> FIG. 8 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model 1B according to the third embodiment. 3 The blood vessel simulation device 100B of the embodiment includes a blood vessel model 1B instead of the blood vessel model 1. The blood vessel model 1B does not have the third tube body 30 in the configuration described in the first embodiment. In this way, the blood vessel model 1B may have a two-layer structure of a first tube body 10 corresponding to the tunica adventitia and a second tube body 20 corresponding to the tunica media. 3 Blood vessel model 1 of the embodiment B This also makes it possible to achieve the same effects as the first embodiment described above.

[0047] <Fourth embodiment> FIG. 9 is an explanatory diagram illustrating a cross-sectional configuration of a blood vessel model 1C according to the fourth embodiment. 4 The blood vessel simulation device 100C of the embodiment includes a blood vessel model 1C instead of the blood vessel model 1. The blood vessel model 1C does not have the first tube body 10 in the configuration described in the first embodiment. In this way, the blood vessel model 1C may have a two-layer structure of a second tube body 20 corresponding to the tunica media and a third tube body 30 corresponding to the tunica intima. 4 Blood vessel model 1 of the embodiment C This also makes it possible to achieve the same effects as the first embodiment described above.

[0048] <Fifth embodiment> FIG. 10 is an explanatory diagram illustrating a schematic configuration of a blood vessel simulation device 100D of the fifth embodiment. The blood vessel simulation device 100D does not include the outer tissue model 3 and the circulation pump 9 in the configuration described in the first embodiment. The blood vessel model 1 of the blood vessel simulation device 100D may be used after being moistened with a fluid (e.g., simulated blood such as physiological saline) or may be used in a dry state. In addition, the blood vessel simulation device 100D may include, for example, a water tank capable of being filled with a fluid, and the blood vessel model 1 may be used in a state of being placed in the water tank filled with the fluid. The blood vessel simulation device 100D of the fifth embodiment can also achieve the same effects as those of the first embodiment described above.

[0049] <Modifications of this embodiment> The present invention is not limited to the above-described embodiment, and can be embodied in various forms without departing from the spirit and scope of the invention. For example, the following modifications are also possible.

[0050] [Variation 1] In the above first to fifth embodiments, one example of the configuration of the blood vessel simulation device 100, 100A to 100D has been shown. However, the configuration of the blood vessel simulation device 100 can be modified in various ways. For example, the blood vessel simulation device 100 may have an organ model imitating an organ such as a heart, a liver, or a brain. In this case, the blood vessel model 1 may be provided on the outside or inside of the organ model. For example, the blood vessel simulation device 100 may include a pulsating pump for adding a motion simulating pulsation to the fluid circulated by the circulation pump 9. For the pulsating pump, for example, a positive displacement reciprocating pump or a rotary pump rotated at a low speed can be used.

[0051] [Variation 2] In the above first to fifth embodiments, one example of the configuration of the blood vessel model 1, 1A to 1C is shown. However, the configuration of the blood vessel model 1 can be modified in various ways. For example, the blood vessel portion 10 may have any shape, such as a straight shape, a curved shape, a meandering shape, or the like. For example, the blood vessel portion 10 may be coated with a hydrophilic or hydrophobic resin. For example, the lumen 1L of the blood vessel model 1 may be provided with a lesion simulating a human lesion.

[0052] [Variation 3] The configurations of the blood vessel simulation devices 100, 100A-100D or the blood vessel models 1, 1A-1C of the first to fifth embodiments and the configurations of the blood vessel simulation devices 100, 100A-100D or the blood vessel models 1, 1A-1C of the above-mentioned modified examples 1 and 2 may be appropriately combined. For example, the blood vessel model 1 described in any of the first to third embodiments may be used in the blood vessel simulation device 100 of the fifth embodiment.

[0053] Although the present aspect has been described above based on the embodiment and modified examples, the above-mentioned embodiment of the aspect is intended to facilitate understanding of the present aspect and does not limit the present aspect. The present aspect may be modified or improved without departing from the spirit and scope of the claims, and equivalents are included in the present aspect. Furthermore, if a technical feature is not described as essential in this specification, it may be deleted as appropriate. [Explanation of symbols]

[0054] 1, 1A~1C…Blood vessel model 1L…lumen 1a…Aperture 1b…Aperture 3…External tissue model 4…Container 5...Core material 9…Circulation pump 10,10A…First tube body 20,20A…Second tube body 30,30A…Third tube body 100, 100A~100D...Blood vessel simulation device

Claims

1. A vascular model comprising: A first tube body having a hollow tube shape; a second tube body having a hollow tube shape covering an inner peripheral surface of the first tube body; Equipped with an acoustic impedance of the first tube body is greater than an acoustic impedance of the second tube body; The thickness of the second tube body is greater than the thickness of the first tube body, the first tube body and the second tube body each contain a polymer material and fine particles having an acoustic impedance greater than that of the polymer material, A particulate concentration contained in the first tube body is higher than a particulate concentration contained in the second tube body, A blood vessel model, wherein the particle diameter of the microparticles contained in the first tube body and the particle diameter of the microparticles contained in the second tube body are both within a range of 0.1 μm or more and 500 μm or less.

2. The vascular model according to claim 1 , A blood vessel model, wherein a type of microparticles contained in the first tube body is different from a type of microparticles contained in the second tube body, and the microparticles contained in the first tube body have a higher hardness than the microparticles contained in the second tube body.

3. The vascular model according to claim 1 or 2, the first tube body and the second tube body are each formed of a polymer material; A blood vessel model, wherein the acoustic impedance of a polymer material constituting the first tube body is higher than the acoustic impedance of a polymer material constituting the second tube body.

4. The vascular model according to any one of claims 1 to 3, the first tube body and the second tube body are each formed of a polymer material; A blood vessel model, wherein the hardness of the first tube body is higher than the hardness of the second tube body.

5. The vascular model according to any one of claims 1 to 4, further comprising: a third tube body having a hollow tube shape covering an inner circumferential surface of the second tube body; A blood vessel model, wherein the acoustic impedance of the third tube body is equal to or less than the acoustic impedance of the first tube body and is greater than the acoustic impedance of the second tube body.

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