Lipolysis promoter, and skin external composition and bath agent composition containing the lipolysis promoter

Abstract

To provide a lipolysis promoter for decomposing the fat accumulated in a body.SOLUTION: A lipolysis promoter contains extract of at least one plant selected from the group consisting of Litsea cubeba, Acacia concinna, Gnetum latifolium and Myristica fragrans as an active ingredient.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a lipolysis promoter, and a skin external composition and a bath agent composition each containing the lipolysis promoter. [Background technology]

[0002] Obesity is a cause of various adult diseases, and therefore methods to alleviate it are required. In the past, compositions used to reduce obesity have been orally administered with ingredients such as caffeine and citric acid, but due to safety concerns, their practical use was limited and it was difficult to obtain satisfactory results. Therefore, the obesity reduction effects of plant extracts have been studied. For example, Patent Document 1 describes an obesity improving agent that induces vascular endothelial growth factor C (VEGFC) expression and promotes activation of lymphatic function by transdermally administering apricot kernel extract, valerian extract, hawthorn extract, white lamb extract, etc. Patent Document 2 describes an obesity improving agent that is administered transdermally by the same mechanism as Patent Document 1, containing rose oxide, citronellyl acetate, and niaouli oil as ingredients.

[0003] Furthermore, Patent Document 3 describes that when a ligand agent for peroxisome proliferator-activated receptor (PPAR) containing a plant extract of saw palmetto, Siberian laurel, Asai, cardamom, angelica, guava, Japanese kokusiri, Chinese laurel, Cnidium rhododendron, Hemp, Elderberry, Veronica indicum, Passiflora incarnata, Sakunda, Anise, Common Carrot, Ashwagandha, Calluna vulgare, Common Hawthorn, Flax, Agitatake, Black Locust, and Manchurian Wood is orally or transdermally administered, it enhances lipid metabolism and is effective in the prevention and treatment of obesity.

[0004] Patent Document 4 describes an anti-obesity agent that inhibits the digestion and absorption of carbohydrates and lipids and also inhibits α-amylase and lipase by orally administering extracts from plants such as grape seeds, persimmon leaves, pu-erh tea, Hypericum perforatum, apple, tara, oak, banaba leaves, Mallotus japonicus, Cornus japonica, Aster nut, and Eucommia leaves. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2008-189609 A [Patent Document 2] International Publication No. 2014 / 051113 [Patent Document 3] International Publication No. 2009 / 054504 [Patent Document 4] Japanese Patent Application Publication No. 9-227398 Summary of the Invention [Problem to be solved by the invention]

[0006] Here, the elimination of obesity includes not only preventing fat accumulation but also reducing fat that has already accumulated, and the two are clearly different. Obesity refers to a state in which excess neutral fat (triglyceride) accumulates in adipose tissue, causing the tissue to expand. Obesity prevention involves suppressing this accumulation, but does not reduce the amount of fat tissue that has already accumulated, and therefore does not result in weight loss. In other words, in order to reduce excess fat tissue, the neutral fat stored as fat droplets in white fat cells must be broken down and consumed, and this process is important as the first step in reducing accumulated fat tissue. When neutral fat is broken down in the first step, the fat droplets become smaller, leading to a reduction in the size of white fat cells, and ultimately a reduction in the volume of fat tissue, resulting in weight loss.

[0007] However, the above Patent Documents 1 to 4 did not confirm the decomposition of fat. In particular, Patent Document 4 only acknowledges the effect of inhibiting or suppressing only the digestion and absorption of nutritional components by α-amylase inhibitory action or lipase inhibitory action, and thus does not contribute to weight loss by breaking down fat that has already accumulated in the body. In addition, since it is administered orally, it is not possible to achieve localized weight loss at the site where fat has accumulated, and side effects on the whole body must also be considered. Therefore, an object of the present invention is to provide a lipolysis promoter for breaking down fat accumulated in the body. [Means for solving the problem]

[0008] The present invention has, for example, the following configuration. [1] A fat decomposition promoter comprising, as an active ingredient, an extract of at least one plant selected from the group consisting of Limonium littoralis, Shikakai, Broadleaf Clover, and Nutmeg. [2] The lipolysis promoter according to [1], which contains as an active ingredient an extract of at least one plant selected from the group consisting of Limonium littoralis and Polytrichum commune. [3] A composition for topical application to the skin comprising the lipolysis promoter of [1] or [2]. [4] A bath additive composition comprising the fat decomposition promoter of [1] or [2]. [5] A skin topical composition according to [3] for use in a warm bath after application to at least a part of the body. Effect of the Invention

[0009] According to the present invention, fat decomposition is promoted, and fat accumulated in the body is broken down. [Brief description of the drawings]

[0010] [Figure 1] 1 is a graph showing the lipolysis promoting effect of the plant extract of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] The present invention relates to a lipolysis promoter comprising, as an active ingredient, an extract of at least one plant selected from the group consisting of Limonium littoralis, Shikakai, Polygala officinalis, and Nutmeg.

[0012] 1.Plants The plant used for the plant extract that serves as the active ingredient of the lipolysis promoter is at least one selected from the group consisting of the following plants. Litsea cubeba, Acacia concinna, Gnetum latifolium and nutmeg (Myristica fragrans). Among these, Limonium sieboldii and Limonium sieboldii are preferred, with Limonium sieboldii being more preferred, from the viewpoint of promoting lipolysis. These may be used alone or in combination of two or more.

[0013] Although not particularly limited, it is preferable to use the fruit part of Limonium littoralis, the fruit part of Shikakai, the leaf and stem parts of Broadleaf Clover, and the fruit part of Nutmeg. The plants may be used as they are or may be dried. They may also be cut, crushed, or pulverized as appropriate for extraction. The extract also contains essential oil. It is also preferable to use essential oil for Limbopogon.

[0014] 2. Extract Production Method The above plants are used in the form of extracts. Examples of the solvent used for extraction include water and organic solvents, which may be used in combination. Examples of the organic solvent include aliphatic alcohols such as methanol, ethanol, propanol, and butanol, esters such as ethyl acetate and butyl acetate, ketones such as acetone and methyl ethyl ketone, hexane, and ethyl ether. These may be used alone or in combination of two or more.

[0015] As the extraction method, a known extraction method can be used, and examples thereof include immersion extraction in which the plant is directly immersed in the above-mentioned solvent and steam distillation. In the immersion extraction, stirring, reflux, etc. may be performed. The extraction temperature and extraction time are also appropriately set depending on the extraction solvent and the subject to be extracted. After extraction, the extraction residue may be separated by filtration, centrifugation or the like, if necessary.

[0016] The above-mentioned plant extract is a product obtained by extracting a plant with water or an organic solvent, or by steam distillation using the above-mentioned method, or by adding the extracted product or the steam distilled product to a mixture of ethyl acetate or butanol and water and subjecting the mixture to liquid phase partitioning. The method for liquid phase partitioning is not particularly limited, and any known method can be used. Furthermore, these products may be used as powders after drying or lyophilization, or may be used after diluting with a solvent or concentrated.

[0017] 3. Fat decomposition promoter The lipolysis promoter in the present invention refers to an agent that has the effect of reducing the volume of lipid droplets. Lipid droplets are organelles that store lipids such as triglycerides and cholesterol, and contain lipids such as neutral fats (triglycerides) within a phospholipid monolayer.

[0018] When triglycerides in lipid droplets are hydrolyzed to fatty acids and glycerol, both are released into the blood and circulate throughout the body, and the fatty acids are then taken up by mitochondria in muscle cells such as skeletal muscles, where they are broken down and released as energy. In this way, the volume of lipid droplets decreases as the neutral fats inside the lipid droplets are broken down into fatty acids and glycerol and released to the outside of the lipid droplets.

[0019] The plant extract used in the present invention has been found to have the effect of reducing the volume of these lipid droplets. As described above, a reduction in lipid droplet volume means that the neutral fat in the lipid droplets is decomposed into fatty acids and glycerol, which leads to a reduction in the size of white fat cells and a reduction in the volume of adipose tissue, which leads to the elimination of obesity, weight loss, etc.

[0020] The preferred amount of the above-mentioned plant extract as a lipolysis promoter is not particularly limited, but the following ranges are preferred from the viewpoint of fully exerting lipolysis promotion and suppressing toxicity. Note that the following concentrations indicate the concentration of the plant extract per volume of the medium in Example 1 described below. For Limonium sieboldii, the concentration is preferably 0.0001mg / mL to 1mg / mL, more preferably 0.001mg / mL to 0.2mg / mL. For Deer Kai, the concentration is preferably 0.001mg / mL to 1mg / mL, more preferably 0.01mg / mL to 0.2mg / mL. For Polytrichum commune, the concentration is preferably 0.001mg / mL to 1mg / mL, more preferably 0.01mg / mL to 0.2mg / mL. For Nutmeg, the concentration is preferably 0.001mg / mL to 1mg / mL, more preferably 0.01mg / mL to 0.2mg / mL.

[0021] 4. Composition The lipolysis promoter can be used as a composition together with other ingredients. This composition can be used for weight loss, lipolysis, obesity improvement, anti-obesity, obesity prevention, obesity prevention, obesity suppression, etc., preferably for weight loss, lipolysis, or anti-obesity, more preferably for weight loss. The composition may also preferably contain other anti-obesity ingredients as optional ingredients.

[0022] Other anti-obesity ingredients include at least one selected from the group consisting of plant extracts other than the above essential ingredient plant extracts, hydroxycitric acid derivatives such as citric acid, hydroxycitric acid, and hydroxycitric acid palmitate (HCAP (registered trademark)), xanthine derivatives such as theophylline and caffeine, β-adrenergic stimulants such as butopamine and isoproterenol, α-adrenergic inhibitors such as yohimbine and ergotoxine, bipyridine derivatives such as milrinone and amrinone, tea extracts, and carnitine derivatives such as carnitine and Hi-carnitine. These may be used alone or in combination of two or more.

[0023] Examples of the optional plant extracts include Iris florentina, Zingiber officinale, Thyme (Thymus serpyllum, Thymus vulgaris, etc.), Hypericum erectum, Skimmia japonica (Thunb.) var. intermedia Komatsu f. repens, Amomum tsao-ko, Broad-leaved tea tree (Melaleuca quinquenervia), and Crataegus laevigata. These may be used alone or in combination of two or more. Among these, ginger, Hypericum, Balsam Pineapple, and Amomum tsaouko are preferred, and ginger and Hypericum are more preferred. For Iris savory, it is preferable to use the rhizome part, for Ginger, it is preferable to use the rhizome part, for Thyme, it is preferable to use the above-ground part, for Hypericum perforatum, it is preferable to use the above-ground part, for Halliwellia, it is preferable to use the whole plant part, for Amomum tsaoco, it is preferable to use the fruit part, for Broad-leaved tea tree, it is preferable to use the leaf part, and for Crataegus monogyna, it is preferable to use the leaf and fruit parts. The method for producing these plant extracts is the same as the method for producing the plant extracts described above. The concentration of these plant extracts per volume of the medium in Example 1 described later is preferably 0.001 mg / mL to 1 mg / mL, more preferably 0.01 mg / mL to 0.2 mg / mL for sweet iris. Preferably 0.001 mg / mL to 1 mg / mL or more, more preferably 0.005 mg / mL to 0.1 mg / mL or more for ginger. Preferably 0.001 mg / mL to 1 mg / mL, more preferably 0.01 mg / mL to 0.2 mg / mL for thyme. Preferably 0.001 mg / mL to 1 mg / mL, more preferably 0.01 mg / mL to 0.2 mg / mL for Hypericum. Preferably 0.001 mg / mL to 1 mg / mL, more preferably 0.01 mg / mL to 0.2 mg / mL for Morning Glory. Preferably 0.001 mg / mL to 1 mg / mL, more preferably 0.005 mg / mL to 0.1 mg / mL for Halloumis. Amomum tsaoco is preferably 0.001mg / mL to 1mg / mL, more preferably 0.01mg / mL to 0.2mg / mL, broad-leaved tea tree is preferably 0.001mg / mL to 1mg / mL, more preferably 0.005mg / mL to 0.1mg / mL, and hawthorn is preferably 0.001mg / mL to 1mg / mL, more preferably 0.01mg / mL to 0.2mg / mL.

[0024] <Skin external composition> When the above composition is used as an external skin composition, it has the effect of tightening the area where it is used. The composition for external use on the skin may contain, in addition to the above-mentioned anti-obesity component, pharma- ceutical acceptable additives and additives that can be applied to the skin as optional components. For example, moisturizers, oily components, UV absorbers, surfactants, thickeners, alcohols, powder components, scrubs, colorants, aqueous components, water, anti-inflammatory agents, disinfectants, antioxidants, preservatives, skin nutrients, etc.

[0025] The content of the plant extract as an essential component in the composition for external use on the skin is not particularly limited, but is preferably 0.0001 to 10% by mass, more preferably 0.001 to 1% by mass, based on the entire composition for external use on the skin. The dosage form of this topical skin composition is not particularly limited, but examples include liquids such as lotions and emulsions, creams, gels, ointments, packs, sticks, sheets, poultices, powders, granules, etc.

[0026] The method of using the above-mentioned skin external composition is not particularly limited, as long as it is applied to the skin.The place to be applied is not particularly limited, but it is preferable to apply it to the place where fat accumulation is reduced, such as the abdominal area, upper arm, thigh, calf, face, etc. After applying to the skin, it is preferable to at least warm the applied place, and it is also preferable to massage the applied place.

[0027] A more preferred method of use is to apply the above-mentioned skin topical composition to at least a part of the body and take a warm bath. This is because direct application to the skin can deliver a high concentration of the lipolysis promoter locally to the adipose tissue, and the area where the skin topical composition is applied can be warmed by taking a warm bath. When the lipolysis promoter contains an oily plant extract, it is poorly compatible with water and is also fat-soluble, so it is easily absorbed into the body even in water, and is therefore preferably used for this method of use.

[0028] <Bath agent composition> The above composition can be used as a bath agent composition. The bath agent composition may contain, as optional ingredients, ingredients known as ingredients for bath agent compositions in addition to the above anti-obesity ingredient. Examples of such optional components include surfactants, carbonates, organic acids, inorganic pigments, moisturizers, preservatives, fragrances, inorganic salts, oily components, lubricants, water-soluble polymers, opacifiers, colorants, and the like. The content of the plant extract, which is an essential component in the bath agent composition, is not particularly limited, but is preferably 0.0001 to 10 mass % and more preferably 0.001 to 1 mass % based on the total bath agent composition. The bath agent can be used without any restrictions as long as it is a normal bath agent used by dissolving it in water (hot water) and using it. It can also be used for full body bathing, half body bathing, foot bathing, etc. The amount used is not particularly limited, but the amount of the bath agent composition per 200 L of water is preferably 20 to 200 g.

[0029] The form of the bath additive is not particularly limited, but examples include powder, granules, liquid, tablets, briquettes, flakes, and the like.

[0030] Specific examples of the optional components of the skin external application composition and bath agent composition include the following.

[0031] Examples of the surfactant include a nonionic surfactant, an anionic surfactant, and a cationic surfactant.

[0032] Examples of carbonates include sodium carbonate, sodium hydrogen carbonate, magnesium carbonate, potassium carbonate, potassium hydrogen carbonate, sodium sesquicarbonate, ammonium carbonate, calcium carbonate, etc., and examples of organic acids include succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, citric acid, malonic acid, maleic acid, etc. One or more of these carbonates and organic acids can be used, and a combination of both to form effervescent granules can also be used.

[0033] Examples of inorganic pigments include titanium oxide, calcium carbonate, magnesium carbonate, zinc oxide (zinc white), talc, calcium silicate, silicic anhydride, kaolin, bentonite, and titanium mica.

[0034] Examples of moisturizing agents include sugars such as sorbitol, xylitol, maltitol, dextrin, glucose, maltose, lactose, saccharose, xylose, fructose, mannitol, and lactitol; polyhydric alcohols such as ethylene glycol, propylene glycol, 3-methyl-1,3-butanediol, glycerin, and 1,3-butylene glycol; amino acids such as sodium pyrrolidone carboxylate and sodium glutamate; urea; plant-derived extracts; and herbal medicines.

[0035] Examples of preservatives include paraoxybenzoic acid esters (eg, methylparaben), benzoic acid, benzoates, and phenoxyethanol.

[0036] Examples of the fragrance include natural fragrances such as lavender oil and jasmine oil, and synthetic fragrances such as geraniol and phenethyl alcohol.

[0037] Examples of inorganic salts include sodium sulfate, magnesium sulfate, sodium chloride, potassium chloride, sodium thiosulfate, magnesium oxide, aluminum sulfate, alum, and metasilicates.

[0038] Examples of oily components include natural fats and oils such as soybean oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, rice bran oil, mink oil, beef tallow, and lard, hardened oils obtained by hydrogenating these natural fats and oils, and synthetic glycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride, and diglycerides; waxes such as carnauba wax, whale wax, beeswax, and lanolin; hydrocarbons such as liquid paraffin, petrolatum, paraffin, microcrystalline wax, ceresin, squalane, and pristane; lauric acid, myristic acid, and the like. Examples of such oils include higher fatty acids such as carboxylic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolin fatty acid, and isostearic acid; higher alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, and 2-hexyldecanol; esters such as cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, and cholesterol isostearate; essential oils; and silicone oils.

[0039] Examples of lubricants include kaolin, polyethylene glycol, talc, magnesium stearate, calcium stearate, silicone oil, oily components, and starch.

[0040] Examples of water-soluble polymers include natural water-soluble polymers such as corn starch, glue, gelatin, collagen, casein, sodium alginate, carrageenan, furcellaran, tamarind gum, pectin, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, dextran, dextrin, agar, and starch; semi-synthetic water-soluble polymers such as carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cellulose acetate phthalate, propylene glycol alginate, oxidized starch, esterified starch, etherified starch, and cationic starch; and synthetic water-soluble polymers such as sodium polyacrylate, polyethyleneimine, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone, and carboxyvinyl polymer.

[0041] Examples of opacifying agents include titanium oxide coated with dextrin and titanium oxide coated with sodium carboxymethylcellulose.

[0042] These can be used alone or in combination of two or more. The skin external composition and bath agent composition can be produced by mixing the lipolysis promoter of the present invention with any of the above-mentioned anti-obesity ingredients and other ingredients, if necessary, in a conventional manner. EXAMPLES

[0043] The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The concentrations of plant extracts and the like in the examples are concentrations per volume of medium.

[0044] [Preparation of lipid droplet accumulation samples] Adipose precursor cells (3T3-L1, Dainippon Pharmaceutical Co., Ltd.) were seeded at 1×104 cells / well on a 96-well black plate (Greiner Bio-One Co., Ltd.) and cultured and expanded in DMEM medium (low glucose) (Wako Pure Chemical Industries, Ltd.) containing 10% fetal bovine serum (FBS) (Hyclone) in a 37℃-5% CO2 incubator. After 24 hours of culture, the medium was replaced with a medium containing 0.25μM dexamethasone, 0.5mM 1-methyl-3-isobutylxanthine, and 1μg / mL insulin. After inducing differentiation into adipocytes for 48 hours, the medium was replaced with a medium containing 10% fetal bovine serum (FBS) and 1μg / mL insulin, and then every other day the medium was replaced with a medium containing 10% fetal bovine serum (FBS) and 1μg / mL insulin, and the cells were cultured for 4 days to obtain lipid droplet accumulation samples. Accumulation of lipid droplets within the cells was confirmed by visual inspection at 100x magnification under an optical microscope (DIAPHOT, manufactured by Nikon Corporation).

[0045] After the culture was completed, the medium was replaced with phosphate-buffered saline (PBS), and AdipoRed (registered trademark) assay reagent (manufactured by Lonza) was added to stain the lipid droplets. The fluorescence intensity of the stained lipid droplets was measured at 572 nm using a fluorometer (EnSpire, manufactured by PerkinElmer), and the value obtained in the control (untreated) group was used as the initial value.

[0046] [Preparation of extract] Table 1 below shows the plants and the parts used for the plant extracts in Examples 1 to 12. Details of the maceration extraction method and the steam distillation method are as follows. Dried and crushed products of the parts of each plant were used for the maceration extraction and the steam distillation.

[0047] [Table 1]

[0048] Immersion Extraction Method (Used in Examples 1-9) 20 g of the ground material from each of the parts shown in Table 1 above was immersed in 200 mL (10 (W / V) times the amount) of 50% ethanol by volume, and extracted by heating under reflux for 2 hours. After filtration, an extract was obtained. The entire extract was concentrated and then freeze-dried, and dissolved or suspended in 80 mL of distilled water, to which 40 mL of ethyl acetate was added and stirred to obtain a separated extract. The obtained extract was concentrated and freeze-dried, and then subjected to testing.

[0049] Steam distillation method (used in Examples 10 to 12) The parts shown in Table 1 above were placed in a steam distillation pot, and steam distillation was carried out under conditions of an internal temperature of approximately 100°C and a distillate temperature of room temperature to obtain a distillate. The distillate obtained was separated into an oil layer and an aqueous layer, and the obtained oil layer was dehydrated with anhydrous sodium sulfate while being heated to approximately 40°C, and then filtered to obtain the desired essential oil components.

[0050] [Example 1] The medium for the lipid droplet accumulation sample was replaced with a medium containing 10 μg / mL insulin and 0.003 mg / mL Limonium littoralis maceration extract every day, and the culture was continued for 3 days. After the culture was completed, the medium was replaced with phosphate buffered saline (PBS), and AdipoRed (registered trademark) assay reagent (manufactured by Lonza) was added to stain the lipid droplets. The fluorescence intensity of the stained lipid droplets was measured at 572 nm using a fluorometer (EnSpire, manufactured by PerkinElmer). The value (%) of the obtained measured value relative to the initial value was calculated, and the value was subtracted from 100 (%) to obtain the volume reduction rate of lipid droplets.

[0051] [Examples 2 to 9] The volume reduction rate of lipid droplets was determined in the same manner as in Example 1, except that the plant extract was the plant maceration extract and the amount added shown in Table 2.

[0052] [Examples 10 to 12] The volume reduction rate of lipid droplets was determined in the same manner as in Example 1, except that Limonium littoralis essential oil obtained by steam distillation was used as the plant extract and added in the amounts shown in Table 2.

[0053] [Comparative Example 1] The volume reduction rate of lipid droplets was determined in the same manner as in Example 1, except that 0.05 mg / mL of hydroxycitric palmitate (HCAP) was used instead of the Limonium littoralis extract.

[0054] [Comparative Example 2] The volume reduction rate of lipid droplets was determined in the same manner as in Example 1, except that 0.05 mg / mL of caffeine was used instead of the Limonium littoralis extract.

[0055] The results of each of the examples and comparative examples are shown in Table 2.

[0056] [Table 2]

[0057] As can be seen from Table 2, a volume reduction rate of 10% or more was observed in all examples. In particular, Example 2, which used Limonium littoralis, showed a volume reduction rate of nearly 32% at a concentration of 0.010 mg / mL, and Example 3 showed a volume reduction rate of nearly 36% at a concentration of 0.030 mg / mL, indicating that Limonium littoralis extract has a particularly excellent effect in promoting lipolysis. When Limonium littoralis essential oil was used at a concentration of 0.010 mg / mL, a volume reduction rate of nearly 40% was observed. In addition, at a concentration of 0.010 mg / mL, Shikakai and Hirohagnemon also achieved a lipolysis promoting effect of 30% or more.

[0058] Formulation examples of the lipolysis promoter of the present invention are shown below, but the practice of the present invention is not limited to the following. <External skin preparations> Ingredients Amount (mass%) Stearic acid 2.0% Stearyl alcohol 3.0% Deodorized Lanolin 2.0% Olive oil 15.0% Glyceryl monostearate 2.0% Caprylic / capric triglyceride 5.0% 1,3-Butylene glycol 3.0% Sorbitol 1.0% Diglycerin 1.0% Xanthan gum 0.25% Carboxyvinyl polymer 0.1% Limonium cuspidatum extract 0.02% Hypericum extract 0.02% fragrance trace amount Distilled water remaining

[0059] <External skin preparations> Ingredients Amount (mass%) Stearic acid 2.0% Stearyl alcohol 3.0% Deodorized Lanolin 2.0% Olive oil 15.0% Glyceryl monostearate 2.0% Caprylic / capric triglyceride 5.0% 1,3-Butylene glycol 3.0% Sorbitol 1.0% Diglycerin 1.0% Xanthan gum 0.25% Carboxyvinyl polymer 0.1% Shikakai extract 0.02% Ginger extract 0.02% fragrance trace amount Distilled water remaining

[0060] <Bath additives> Ingredients Amount (mass%) Sodium sulfate 69.2% Sodium bicarbonate 23.3% Silica anhydride 0.5% Calcium carbonate 1.0% Fragrance 0.8% Broadleaf Nemone Extract 0.1% Hypericum extract 0.1% Opacifying agent * 5.0% *Opacifying agent: Titanium oxide coated with dextrin

[0061] <Bath additives> Ingredients Amount (mass%) Sodium sulfate 69.2% Sodium bicarbonate 23.3% Silica anhydride 0.5% Calcium carbonate 1.0% Fragrance 0.8% Nutmeg extract 0.1% Ginger extract 0.1% Opacifying agent * 5.0% *Opacifying agent: Titanium oxide coated with dextrin

[0062] <Bath additives> Ingredients Amount (mass%) Liquid paraffin 30.0% Rice bran oil 10.0% POE Cetyl Ether 2.5% Sorbitan monopalmitate 2.5% Phenoxyethanol 0.3% Fragrance 0.5% Litsea Cubeb Extract 0.1% Ginger extract 0.1% Methyl paraoxybenzoate 0.2% Distilled water remaining

[0063] <Bath additives> Ingredients Amount (mass%) Liquid paraffin 30.0% Rice bran oil 10.0% POE Cetyl Ether 2.5% Sorbitan monopalmitate 2.5% Phenoxyethanol 0.3% Fragrance 0.5% Shikakai extract 0.1% Hypericum extract 0.1% Methyl paraoxybenzoate 0.2% Distilled water remaining

[0064] <Bath additives> Ingredients Amount (mass%) Fumaric acid 20.0% Malic acid 18.0% Sodium bicarbonate 21.0% Sodium carbonate 20.0% Sodium sulfate 18.58% POE (Caprylic / Capric Acid) Glyceryl 0.2% Ethylenediaminetetra POE·POP 0.02% Soybean oil 0.3% Polyvinylpyrrolidone 0.2% PEG6000 0.5% Broadleaf Nemone Extract 0.1% Ginger extract 0.1% Fragrance 1.0%

[0065] <Bath additives> Ingredients Amount (mass%) Fumaric acid 20.0% Malic acid 18.0% Sodium bicarbonate 21.0% Sodium carbonate 20.0% Sodium sulfate 18.58% POE (Caprylic / Capric Acid) Glyceryl 0.2% Ethylenediaminetetra POE·POP 0.02% Soybean oil 0.3% Polyvinylpyrrolidone 0.2% PEG6000 0.5% Nutmeg extract 0.1% Hypericum extract 0.1% Fragrance 1.0%

Claims

1. A lipolysis promoter containing, as an active ingredient, an extract obtained by extracting the fruits of Limbopogon with a solvent containing aliphatic alcohol.

2. A fat decomposition promoter containing an extract of Limbopogon berries extracted by steam distillation as the active ingredient.

Images