Skin adhesive sheet

Abstract

To provide an adhesive sheet for skin, which has a satisfactory adhesion force, and in which a drug can be stably dissolved or uniformly dispersed, and which is produced using an acrylic copolymer having excellent solubility in a hydrophilic medium.SOLUTION: The adhesive sheet for skin includes an adhesive layer comprising an acrylic resin having "hardness" of 2.0 or less and / or "an IR intensity ratio" of 2.0 or more. The "hardness" refers to a value (unit: N) of a compressive stress at a depth of compression of 0.1 to 0.2 mm in a (compressive stress)-to-(depth of compression) curve, in which the (compressive stress)-to-(depth of compression) curve is obtained by producing a sheet having a thickness of 3 mm from an acrylic resin and then compressing a stainless cylinder having a diameter of 1.5 mm from the upper surface of the sheet at a compression rate of 0.5 mm / min using a compact tabletop tester EZ Test EZSX (Shimadzu Corporation).SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an adhesive sheet for skin. [Background technology]

[0002] Conventionally, patches for application to the skin, such as poultices, cooling sheets, tapes, etc., in which a hydrophilic adhesive composition for external use on the skin having adhesiveness is spread on a support, have been developed as external preparations or cosmetics. Such preparations are required to adhere to the skin for a certain period of time without peeling off, and it is also important that the drug is stably and uniformly dispersed or dissolved in the adhesive layer.

[0003] As conventional patches, many of the patches using hydrophilic adhesive compositions use sodium polyacrylate as an adhesive, and there are known a poultice containing a synthetic polymer gel mainly composed of an aluminum salt of an aliphatic carboxylic acid such as polyacrylic acid (Patent Document 1), a transdermal absorbable preparation consisting of polyacrylic acid having a 10% aqueous solution viscosity of 100 to 1000 cps, a water-soluble polymer, a polyhydric alcohol, and water (Patent Document 2), a hydrous gel patch consisting of an N-vinylacetamide / sodium acrylate copolymer, a water-soluble aluminum salt, and water (Patent Document 3), and a cataplasm containing polybutene and gelatin (Patent Document 4). However, conventional hydrophilic adhesive compositions and hydrophilic patches have problems such as insufficient adhesive strength and difficulty in practical use. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 60-226808 [Patent Document 2] Japanese Patent Application Publication No. 6-135828 [Patent Document 3] Japanese Patent Application Publication No. 9-143060 [Patent Document 4] Japanese Patent Application Publication No. 9-208462 Summary of the Invention [Problem to be solved by the invention]

[0005] The object of the present invention is to improve the solubility in hydrophilic media and adhesive strength to skin of the above-mentioned acrylic copolymer, i.e. to provide an adhesive sheet for skin using an acrylic copolymer that has sufficient adhesive strength, can stably dissolve or uniformly disperse a drug, and has excellent solubility in hydrophilic media. [Means for solving the problem]

[0006] The inventors have conducted intensive research to solve the problems described above, and as a result have discovered that by using adhesives, representative examples of which are alkyl acrylate copolymer ammonium, alkyl acrylate / vinyl acetate copolymer, and styrene / alkyl acrylate copolymer ammonium, it is possible to obtain an adhesive sheet for skin which has excellent adhesion to the skin, is pleasant to use, and is capable of stably dissolving or uniformly dispersing drugs, thereby completing the present invention. The present invention is as follows. [1] An adhesive sheet for skin comprising an adhesive layer containing an acrylic resin having a "hardness" of 2.0 or less and / or an "IR intensity ratio" of 2.0 or more. [2] The pressure-sensitive adhesive sheet according to [1], wherein the acrylic resin has a "hardness" of 2.0 or less and an "IR intensity ratio" of 2.0 or more. [3] The pressure-sensitive adhesive sheet according to [1] or [2], wherein the acrylic resin is at least one selected from the group consisting of ammonium alkyl acrylate copolymer, alkyl acrylate / vinyl acetate copolymer, and styrene / ammonium alkyl acrylate copolymer. [4] The pressure-sensitive adhesive sheet according to any one of [1] to [3], wherein the pressure-sensitive adhesive layer further contains a surfactant. [5] The pressure-sensitive adhesive sheet according to [4], wherein the surfactant has an HLB value of 3.5 or more and 12 or less. [6] The content of the surfactant is 1% by mass or more and Mass % The adhesive sheet according to [4] or [5], characterized in that: [7] The pressure-sensitive adhesive sheet according to any one of [1] to [6], wherein the pressure-sensitive adhesive layer further contains a polyhydric alcohol. [8] The adhesive sheet according to any one of [1] to [7], wherein the adhesive layer further contains a skin active substance. [9] A laminated adhesive sheet for skin, comprising the adhesive sheet according to any one of [1] to [8] and a support sheet made of an acrylic resin having a "hardness" of 5.0 or more and an "IR intensity ratio" of less than 2.0. Effect of the Invention

[0007] The adhesive sheet for skin of the present invention has strong adhesive strength and is excellent in stable solubility or uniform dispersibility of drugs and the like. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] Adhesive / Adhesive Layer The adhesive layer in the present invention can be an adhesive sheet made of a commercially available adhesive. Rubber-based adhesives are not preferred because they have low water vapor permeability and are prone to skin irritation due to sweat accumulation in summer. Silicone-based adhesives generally have low adhesion and can be inconvenient to use. Considering the adhesion to the skin and the adhesion to the support film, acrylic adhesives are preferred.

[0009] Specifically, it is a copolymer of an alkyl acrylate ester, and a copolymer of an alkyl acrylate ester mainly with acrylic acid, acrylamide, vinyl acetate, etc. In order to improve the skin adhesion, a plasticizer such as glycerin, isopropyl myristate, or isopropyl palmitate may be added to these adhesives. The thickness of the adhesive layer is, for example, 10 μm to 800 μm. In particular, in the case of application to the skin, in order to improve the feeling of use, it is preferably 50 μm to 500 μm, and more preferably 100 μm to 300 μm. If it is less than 100 μm, a good feeling of use can be obtained, but the usability may be deteriorated due to the thinness. Furthermore, these adhesives may be used in the form of a sheet of one type of adhesive, or may be used by laminating several layers of the adhesive.

[0010] Many adhesive acrylic ester resins are commercially available, and their mechanical properties were measured to select resins with properties suitable for use as adhesives. Several types of acrylic resins were used to prepare sheets with a thickness of 3 mm, and a stainless steel cylinder with a diameter of 1.5 mm was compressed from above using a small tabletop tester EZ Test EZSX (manufactured by Shimadzu Corporation) (compression speed: 0.5 mm / min). The value of the compressive stress (N: unit) at a compression depth of 0.1 to 0.2 mm at which a stable compressive stress was obtained in the obtained compressive stress-compression depth curve is defined as "hardness" in the present invention. "Hardness" refers to the compressive stress value (unit: N) at a compression depth of 0.1 to 0.2 mm on the compression stress-compression depth curve obtained by preparing a 3 mm thick sheet from an acrylic resin and compressing a 1.5 mm diameter stainless steel cylinder from above the sheet at a compression speed of 0.5 mm / min using a small benchtop testing machine EZ Test EZSX (manufactured by Shimadzu Corporation).

[0011] The infrared absorption spectrum of the acrylic resin was also measured to determine whether it could be used as an adhesive or a support film. -1 Absorption intensity of nearby peaks and 1230cm -1Ratio of absorption intensities of adjacent peaks (Int1230cm -1 / Int2900cm -1 ) will be referred to as the "IR intensity ratio" from now on. -1 is due to the C-O-C bending vibration of acrylic ester, and 2900 cm -1 originates from CH and C-H2 stretching vibrations.

[0012] As a result of evaluating the hardness, adhesiveness, and mechanical strength of many of the resins tested, it was found that acrylic resins with a hardness of 4.0 or less, preferably 3.0 or less, and more preferably 2.0 or less are suitable as acrylic adhesives in the present invention. As a result of evaluating the IR intensity ratio and adhesiveness of many of the resins tested, it was found that acrylic resins with an IR intensity ratio of 2.0 or more are preferred as acrylic adhesives in the present invention.

[0013] A measurement example is given below. Suitable adhesives that can be used include Vinizol 1087FT (acrylates copolymer ammonium, manufactured by Daido Chemical Industry Co., Ltd., (hardness: 0.2) (IR intensity ratio: 2.9)), Yodozol GH800 F (acrylate alkyl copolymer ammonium, manufactured by Akzo Nobel Co., Ltd., (hardness: 0.8) (IR intensity ratio: 3.3)), and MASCOS (registered trademark) 10 adhesive (acrylic ester, manufactured by Cosmedi Pharmaceutical Co., Ltd., (hardness: 0.4) (IR intensity ratio: 2.24)).

[0014] Yodosol GH41F (styrene / alkyl acrylate copolymer ammonium, Akzo Nobel (hardness: 8.2), (IR intensity ratio: 1.1)) is hard and can be used for substrates, but is unsuitable for adhesive applications.

[0015] support The film used for the support is preferably a film made of a synthetic polymer, and must have excellent adhesion to the acrylic adhesive, maintain strength, and be easily moldable into a thin film. Conventionally used polyolefins, PET (polyethylene terephthalate), polyvinyl alcohol, polyurethane, etc. can also be used, but in the present invention, a hard acrylic resin that has good affinity with the acrylic adhesive and therefore has excellent adhesion can be preferably used.

[0016] skin valuables In addition to the support and the adhesive layer, the adhesive layer may contain a skin valuable in the present invention. The skin valuable is not particularly limited as long as it is a valuable that can be absorbed through the skin. For example, pigmentation inhibitors, moisturizers, metabolic activators, antioxidants, active oxygen scavengers / radical scavengers, fat metabolism promoters, anti-inflammatory agents, blood flow promoters, testosterone 5α reductase activity inhibitors, hair papilla activators, hair growth promoters, etc. may be mentioned.

[0017] Pigmentation inhibitor The present invention can include a pigmentation inhibitor. Specific examples of the pigmentation inhibitor include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or its salts and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or its salts and derivatives thereof, tocopherol or its salts and derivatives thereof, etc.

[0018] Moisturizer A moisturizing agent may be added to the composition of the present invention.Specific examples of moisturizing agents include quince seeds, agar or derivatives thereof, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, pyralose, 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and sorbitol, 1,2-propanediol, 1,3-propanediol, and the like. polypropylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, erythritol, pentaerythritol, dipentaerythritol, xylitol, maltitol, inositol, panthenol, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethylchitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan cellulose, alginic acid or its salts, hyaluronic acid or its salts, chondroitin sulfate or its salts, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyacrylates water-soluble polymers such as carboxyvinyl polymers, dermatan sulfate, and keratan sulfate; pyrrolidone carboxylic acid or a salt thereof, polyglutamic acid or a salt thereof, pyrrolidone carboxylic acid contained in natural moisturizing factors, urea, urocanic acid, betaine, sodium lactate, aspartic acid, glutamic acid, isoleucine, histidine, phenylalanine, threonine, serine, valine, proline, glycine, alanine, lysine, arginine, and ceramides such as ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6II, and ceramide 9.

[0019] Metabolic Activators A metabolic activator can be added to the present invention. Specific examples of metabolic activators include vitamin A group: retinol or its salt and derivatives thereof, retinal or its salt and derivatives thereof, dehydroretinal or its salt and derivatives thereof, retinoic acid or its salt and derivatives thereof, carotene or its salt and derivatives thereof, lycopene or its salt and derivatives thereof, Vitamin B group: thiamine or its salts and derivatives, riboflavin or its salts and derivatives, pyridoxine or its salts and derivatives, pyridoxal or its salts and derivatives, cyanocobalamin or its salts and derivatives, folic acid or its salts and derivatives, nicotinic acid or its salts and derivatives, pantothenic acid or its salts and derivatives, biotin or its salts and derivatives, choline or its salts and derivatives, inositol or its salts and derivatives, Vitamin C: ascorbic acid or its salts and their derivatives, Vitamin D group: ergocalciferol or its salts and derivatives thereof, cholecalciferol and its salts and derivatives thereof, Vitamin E group, etc.: tocopherol or its salts and derivatives thereof, tocotrienol or its salts and derivatives thereof, ubiquinone or its salts and derivatives thereof, linoleic acid or its salts and derivatives thereof, linolenic acid or its salts and derivatives thereof, Other amino acids: amino acids such as valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, or derivatives thereof, and their sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidone carboxylic acid; Examples of such active ingredients include α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, and succinic acid, 2-hydroxycarboxylic acids, polyhydroxycarboxylic acids or hydroxypolycarboxylic acids, lactobionic acid, photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, trimethylglycine, and proteoglycan.

[0020] Antioxidants In the present invention, an antioxidant can be added. Specific examples of the antioxidant include ascorbic acid or a salt thereof and a derivative thereof, tocopherol or a salt thereof and a derivative thereof, tocotrienol or a salt thereof and a derivative thereof, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), coenzyme Qn (n=7 to 10), pyrroloquinoline quinone, propyl gallate, sesamol, carotenoids, etc.

[0021] Active oxygen scavengers / radical scavengers In the present invention, an active oxygen scavenger / radical scavenger can be added. Specific examples of the active oxygen scavenger / radical scavenger include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or a derivative thereof, gallic acid or a salt thereof and a derivative thereof, curcumin or a salt thereof and a derivative thereof, transferrin, ceruloplasmin, coenzyme Qn (n=7-10), uric acid, bilirubin, metallothionein, and the like.

[0022] Fat metabolism promoter A fat metabolism promoter may be added to the present invention. Specific examples of fat metabolism promoters include xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprophylline, proxyphylline, oxtriphylline, etc.), Aotsurafuji extract, thistle extract, Aotsurafuji extract, Zedoary extract, Platycodon grandiflorum (Platycodon grandiflorum, Platycodon root) extract, Ivy extract, and Pepper extract.

[0023] Anti-inflammatory agents Anti-inflammatory agents can be added to the present invention. Specific examples of anti-inflammatory agents include quinolinone derivatives, dibenzoxepin derivatives, tiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivatives, chalcine compounds, chromanol glycosides (2-(α-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol), ichthammol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, chamazulene, and chlorphenyl maleate. amine, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or a salt thereof and a derivative thereof, glycyrrhetinic acid or a salt thereof and a derivative thereof, mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, panthenol or a salt thereof such as pantothenyl ethyl ether and a derivative thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or a derivative thereof, sulfatide, chlorpheniramine maleate, diphenhydramine hydrochloride, and the like.

[0024] Blood flow promoter A blood flow promoter can be added to the present invention. Specific examples of blood flow promoters include tocopherol or its salts and derivatives thereof, tocotrienol or its salts and derivatives thereof, cepharanthine, carpronium chloride, eugenol derivatives, minoxidil, capsicum tincture, nonylic acid vanillamide, cantharides tincture, ginger tincture, L-menthol, camphor, benzyl nicotinate, ichthammol, α-borneol, nonylic acid vanillamide, capsaicin, Swertia japonica extract, garlic extract, carrot extract, gentian extract, Angelica acutiloba extract, ginger extract, Swertia japonica (this medicine) extract, etc.

[0025] Testosterone 5α-reductase inhibitor, hair papilla activator, hair growth promoter The present invention can include a testosterone 5α reductase inhibitor, a hair papilla activator, and a hair growth promoter. Specific examples of the testosterone 5α reductase inhibitor, a hair papilla activator, and a hair growth promoter include γ-amino-β-hydroxybutyric acid esters, amine oxides, alkyl betaines, pyrimidine-N-oxide derivatives, acetylcarnitine or its salt, geranylgeranyl acetone, hydroxamic acid derivatives or its salt, and proanthocyanidins.

[0026] Low molecular weight components In addition to the above-mentioned components, the present invention may contain low molecular weight components that are usually used in skin external preparations such as cosmetics and pharmaceuticals. The low molecular weight components are composed of one or more components such as other aqueous components, oily components, plant extracts, animal extracts, powders, surfactants, oils, alcohols, pH adjusters, preservatives, thickeners, colorants, and fragrances, which are part of the base and may also function as valuable substances due to their effects on the skin.

[0027] The surfactant preferably has an HLB value of 3.5 or more and 12 or less. When the HLB value is within this range, the adhesive is easier to mold, and the feel of the molded adhesive sheet is also good. The surfactant content is 1% by mass or more and 20% by mass or more of the adhesive layer. Mass % The content is preferably 2% by mass or more and 15% by mass or less.

[0028] As the alcohol, in order to adjust the viscosity of the adhesive coating liquid, polyhydric alcohols such as ethylene glycol, glycerin, and propylene glycol are preferred, with glycerin being preferred. The content of polyhydric alcohol is 0.2% by mass or more relative to the adhesive layer. Mass % The content is preferably 0.5% by mass or more and 3.0% by mass or less.

[0029] Method for manufacturing adhesive sheet Adhesive sheets are made by adding plasticizers, surfactants, and other additives to the acrylic adhesive (acrylic polymers are obtained suspended in water or dissolved in an organic solvent) as the main component, and then adding a solvent (water or an organic solvent) to make the coating liquid. The coating liquid is applied to a PET release film so that the thickness after drying is the specified thickness, and the film is dried at about 70 to 90°C for about 10 minutes to obtain the adhesive sheet. The support sheet may be used as it is when it is a polyolefin film, a PET film, etc. When an acrylic resin is used as the support, the support sheet is obtained by a coating method similar to that used for producing the pressure sensitive adhesive sheet. The resulting pressure-sensitive adhesive sheet can constitute the pressure-sensitive adhesive sheet for skin of the present invention by itself. Also included in the pressure-sensitive adhesive sheet for skin of the present invention is a laminate sheet obtained by laminating the resulting pressure-sensitive adhesive sheet and a support sheet. EXAMPLES

[0030] The present invention will now be described in more detail with reference to the following examples. These examples are merely illustrative of the present invention, and the scope of the present invention is not limited to these examples.

[0031] Example 1 An adhesive sheet and a support sheet were prepared and their properties were evaluated. Then, the adhesive sheet and the support sheet were laminated. Preparation of adhesive sheet A coating liquid was prepared by adding isopropyl myristate (Nacalai Tesque, Inc.) and octyldodecyl lactate (Esterol LOD, National Mimatsu Co., Ltd.) as plasticizers to an acrylic ester emulsion adhesive (Vinisol 1087FT, Daido Chemical Industry Co., Ltd., Yodozol GH800F (acrylic acid alkyl copolymer ammonium, Akzo Nobel Co., Ltd.), adding Aronvis AH-106X and glycerin as solution viscosity adjusters, and adding Salacos DG-15 as an emulsifier. The coating liquid was cast onto a PET film and dried by heating at 80°C to form an adhesive sheet with a thickness of 40 μm. Table 1 shows examples of adhesive compositions as Examples 1-4. In Example 1, Yodozol GH41F (acrylic acid alkyl copolymer ammonium, Akzo Nobel Co., Ltd.) was used instead of Yodozol GH800F. All of the above compositions exhibited good adhesion.

[0032] [Table 1]

[0033] Preparation of support sheet Separately, styrene / alkyl acrylate copolymer ammonium (Yodosol GH41F, Akzo Nobel Co., Ltd.) and an acrylic ester emulsion type adhesive (Vinisol 1087FT, Daido Chemical Industry Co., Ltd., Yodozole GH800F (alkyl acrylate copolymer ammonium, Akzo Nobel Co., Ltd.) were cast onto a PET release film, dried by heating at 80°C, and peeled off from the PET release film to obtain a support sheet with a thickness of 30 μm. Examples and comparative examples are shown in Table 2. An adhesive sheet with a support sheet was obtained by laminating the adhesive sheet of Example 1 in Table 1 with five types of support sheets in Table 2. Examples 5 and 6, which have a "hardness" value of 5.0 or more, had high functionality as a support sheet when laminated with an adhesive sheet, but the sheets of Comparative Examples 1, 2, and 3 were soft and did not function as a support sheet.

[0034] [Table 2]

[0035] The "hardness" and "IR intensity ratio" of the adhesives and backings used in Tables 1 and 2 are summarized in Table 3.

[0036] [Table 3]

[0037] Preparation and sensory evaluation of support films containing surfactants with different HLB values Styrene / alkyl acrylate copolymer ammonium (Yodosol GH800F, Akzo Nobel Co., Ltd.) and other ingredients were cast onto a PET release film and dried by heating at 80°C to form an adhesive sheet. The ease of casting onto the PET and the ease of forming into a sheet were evaluated, and the results are shown in Table 4.

[0038] [Table 4]

[0039] Application of the pressure-sensitive adhesive sheet of the present invention 1. Skin care sheets The adhesive sheet of the present invention is used as a sheet for protecting and moisturizing the facial skin, without containing any skin valuable substances in the adhesive layer. 2. Skin care sheets The adhesive sheet of the present invention contains skin valuables in the adhesive layer and is used as a sheet for protecting facial skin, moisturizing, whitening, promoting blood flow, etc. 3. Skin care sheets The adhesive sheet of the present invention is used as an adhesive sheet for backing a microneedle array, with or without a skin valuable substance contained in the adhesive layer.

[0040] As application examples of the above-mentioned cosmetic skin sheet, cosmetic skin sheet compositions are shown in Table 5. Example 12 shows a composition example in which VC ethyl ascorbic acid is blended as a pigmentation inhibitor, Example 13 shows a composition example in which trehalose is blended as a moisturizing agent, Example 14 shows a composition example in which tocopheryl retinoate is blended as a metabolic activator, Example 15 shows a composition example in which tocopherol is blended as an antioxidant, Example 16 shows a composition example in which coenzyme Q10 is blended as an active oxygen scavenger, Example 17 shows a composition example in which dipotassium glycyrrhizinate is blended as an anti-inflammatory agent, and Example 18 shows a composition example in which Swertia japonica extract is blended as a blood flow promoter. The cosmetic skin sheet compositions of Examples 12 to 18 were laminated on the support sheet of Example 10 to form the composition. All of the composition sheets of Examples 12 to 18 laminated onto a support sheet provided a good feel as if they were decorative sheets.

[0041] [Table 5]

[0042] As described above in detail, the adhesive sheet for skin of the present invention has appropriate adhesiveness to the skin and can simultaneously contain skin valuable substances, so that it can also be expected to have a cosmetic effect on the skin.

Claims

1. A skin adhesive sheet comprising an adhesive layer containing an acrylic resin having a "hardness" of 2.0 or less and an "IR intensity ratio" of 2.0 or more, and a surfactant, The "hardness" refers to the value of the compressive stress (unit: N) at a compression depth of 0.1 to 0.2 mm in the obtained compression stress-compression depth curve, obtained by preparing a sheet having a thickness of 3 mm from the acrylic resin, compressing a stainless steel cylinder having a diameter of 1.5 mm from the upper surface of the sheet at a compression speed of 0.5 mm / min using a small tabletop testing machine EZ Test EZSX (manufactured by Shimadzu Corporation); The "IR intensity ratio" is the ratio of the IR intensity at 2900 cm in the infrared absorption spectrum of the acrylic resin. -１ Absorption intensity of nearby peaks and 1230 cm -１ Ratio of absorption intensities of nearby peaks (Int 1230 cm -１ / Int2900cm -１ ) The acrylic resin is at least one selected from the group consisting of alkyl acrylate copolymer ammonium and alkyl acrylate / vinyl acetate copolymer; The skin pressure-sensitive adhesive sheet is characterized in that the surfactant has an HLB value of 3.5 or more and 12 or less, and the content of the surfactant is 1% by mass or more and 20% by mass or less.

2. The adhesive sheet according to claim 1 , wherein the adhesive layer further comprises a polyhydric alcohol.

3. The adhesive sheet according to claim 1 or 2, further comprising a skin active substance in the adhesive layer.

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