Liquid transfer device having a valve

Abstract

To improve a liquid transfer device for administering diluted drug-containing infusion fluid to a patient, thereby minimizing the risk of administering the drug to the patient in a highly concentrated, undiluted state. The liquid transfer device includes an IV spike configured to connect to an infusion container, a compressible vial adapter configured to mount on a vial, an IV port configured to connect to an infusion set, and a valve movable between a first state and a second state upon compression of the vial adapter. The valve is configured to prevent fluid communication between the IV spike, the vial adapter, and the IV port in the first state, and to provide fluid communication between the IV spike and the vial adapter and to provide fluid communication between the IV spike and the IV port in the second state.

Description

Technical Field

[0001] The present disclosure generally relates to liquid transfer devices.

Background Art

[0002] Conventional infusion containers that hold infusions delivered to patients generally take the form of infusion bags (or infusion containers), infusion bottles, etc. Pre-filled syringes or vials are generally used to add high-concentration drugs to the infusion contents via a liquid transfer device to form an infusion containing a diluted drug. Thereafter, an infusion set including an IV spike can be inserted into the IV port of the liquid transfer device to inject the infusion contents containing the drug into the patient. Minimizing the risk that a patient is administered a portion of the drug in a highly concentrated undiluted form is important for patient safety. The present disclosure provides an improved liquid transfer device for injecting an infusion content containing a diluted drug into a patient.

Summary of the Invention

[0003] According to a first embodiment, a liquid transfer device includes an IV spike configured to connect to an infusion container, a compressible vial adapter configured to attach onto a vial, an IV port configured to connect to an infusion set, and a valve movable between a first state and a second state upon compression of the vial adapter. The valve is preferably configured to prevent fluid communication (the flow of fluid back and forth) between the IV spike, the vial adapter, and the IV port in the first state, and to provide fluid communication between the IV spike and the vial adapter and between the IV spike and the IV port in the second state.

[0004] In one aspect, the IV spike of the liquid transfer device may include a first IV spike lumen and a second IV spike lumen configured to provide fluid communication with an infusion container.

[0005] In another aspect, the valve of the liquid transfer device may be configured to provide fluid communication between the first IV spike lumen and the vial adapter and between the second IV spike lumen and the IV port in the second state.

[0006] In another aspect, the valve of the liquid transfer device may include a first lumen configured to provide fluid communication between the first IV spike lumen and the vial adapter, and a second lumen configured to provide fluid communication between the second IV spike lumen and the IV port.

[0007] In another aspect, the vial adapter of the liquid transfer device may include a vial spike for piercing the vial stopper of the vial to provide fluid communication with the vial.

[0008] In another aspect, the vial adapter of the liquid transfer device may include an outer vial adapter body and an inner vial adapter body configured to be attached to the vial, and the inner vial adapter body is configured to slide within the outer vial adapter body when the vial adapter is subjected to compression from a non-compressed state to a compressed state.

[0009] In another aspect, the vial spike of the liquid transfer device may be configured to pierce the vial stopper when the vial adapter is compressed.

[0010] In another aspect, the liquid transfer device may further include a valve actuator movable between a first position and a second position, and the valve actuator is configured to move from the first position to the second position when the vial adapter is compressed.

[0011] In another aspect, the valve actuator of the liquid transfer device may be configured to drive the valve from a first state when the valve actuator is in the first position to a second state when the valve actuator is in the second position when the vial adapter is compressed.

[0012] In another aspect, the valve of the liquid transfer device may comprise an inclined surface configured to engage with a valve actuator.

[0013] In another aspect, the liquid transfer device may further comprise a safety device configured to prevent compression of the vial adapter in the uncompressed state.

[0014] In another aspect, the liquid transfer device may further comprise a connector body to which an IV spike, a vial adapter, and an IV port are coupled, and the valve is movable within the connector body between a first state and a second state.

[0015] In another aspect, the liquid transfer device may further comprise a bore (hole), and the valve may further comprise a locking protrusion, which in the pre-compression state is configured to engage with the bore to prevent movement of the valve between the first state and the second state, and the locking protrusion is configured to change orientation to disengage from the bore so that the valve is movable between the first state and the second state in the compressed state.

[0016] These and other aspects of the liquid transfer devices disclosed herein will become apparent in view of the following description.

Brief Description of the Drawings

[0017] The present disclosure can be understood with reference to the description of the embodiments described below in conjunction with the accompanying drawings.

Figure 1

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BEST MODE FOR CARRYING OUT THE INVENTION

[0018] Figure 1 illustrates a liquid transfer device 110 according to a first embodiment of the present invention. As shown in Figure 1, in one embodiment, the liquid transfer device 110 is intended to be used with an infusion container 102 or an infusion bag and an infusion set 114. As should be understood by those skilled in the art, the infusion container 102 includes a reservoir 106 that contains an infusion and is in fluid communication with an intravenous administration port 108 and an additive port 104. The liquid transfer device 110 of the illustrated embodiment is also intended to be used with an additive transfer device in the form of a sealed vial 112. The vial 112 generally contains a highly concentrated pharmaceutical additive or a lyophilized powder drug that requires reconstitution before administration to a patient, i.e., mixing with the infusion in the infusion container 102 to form an infusion containing the drug to be administered to the patient. Thus, the contents of the vial 112 are introduced into the infusion container 102 via the liquid transfer device 110.

[0019] Figure 2 illustrates a vial 112 having a tubular vial crown 268 with a vial stopper 270 for sealing the vial 112. The vial 112 contains a drug (not shown in Figure 2) for introduction into an infusion to form an infusion containing the drug.

[0020] The liquid transfer device 110 includes a connector body 204. In this embodiment, the connector body 204 has a flow control body 206 on a first arm, an IV port holder 212 on a second arm, and an IV spike 202 on a third arm. The liquid transfer device 110 includes a vial adapter 218 attached to the flow control body 206.

[0021] The flow control body 206 includes a flow control lumen 1006 (see FIG. 10), one bore 608 (see FIG. 6), a valve actuator bore 610 (see FIG. 6), a valve 272, and a valve cavity 604 (see FIG. 6). As shown in FIGS. 6 and 7, the valve 272 is movably received within the valve cavity 604. The flow control body 206 has an end with a vial adapter flange 208 for attachment to a vial adapter 218. The valve actuator bore 610 extends from the valve cavity 604 to the vial adapter flange 208.

[0022] The IV port holder 212 is configured to receive the IV spike 202 of the infusion set 114 for administration purposes. An IV port 212 sealed by a twist-off cap (threaded cap) including a proximal section 216a and a distal section 216b is attached to the IV port holder 214. The IV port 214 includes a septum 1002 (see FIG. 10), which is sealed until a hole is drilled upon insertion of the IV spike 202 of the infusion set 114. As shown in FIG. 12, the distal section 216b is twisted off from the proximal section 216a, thereby exposing the septum 1002 for drilling by the spike 1202 of the infusion set 114 (see FIG. 12). As shown in FIG. 6, the IV port holder 212 has an IV port holder lumen 606 that is in fluid communication with the valve cavity 604 and thus the valve 272.

[0023] The IV spike 202 enables the use of the liquid transfer device 110 with the infusion container 102, i.e., enables the IV spike 202 to be inserted into the intravenous administration port 108 of the infusion container 102 while maintaining a sealed state. The IV spike 202 is in the same direction as the IV port holder 212. As shown in FIG. 10, the IV spike 202 includes a first IV spike lumen 602 and a second IV spike lumen 1010 configured to provide two separate fluid communication paths between the infusion container 102 and the valve cavity 604, and thus the valve 272. In the illustrated configuration, the first IV spike lumen 602 and the second IV spike lumen 1010 extend substantially parallel to each other.

[0024] FIG. 2 also shows the vial adapter 218. The vial adapter 218 includes an inner vial adapter body 244 and an outer vial adapter body 220, and is intended to be compressed from an initial pre-compression state (i.e., non-compressed state) to a final compressed state (i.e., compressed state) in which the outer vial adapter body 220 slidably houses the inner vial adapter body 244 therein. The vial adapter 218 includes a vial spike 242 for piercing the vial stopper 270 of the vial 112 in the compressed state of the vial adapter 218. The vial spike 242 is protected by a thin sheath 264 for maintaining sterility until the liquid transfer device 110 is used to administer the medicated infusion.

[0025] The inner vial adapter body 244 has an inverted cup shape including an inner vial adapter upper wall 260 and a vial crown sleeve 266. The inner vial adapter body 244 partitions an inner cavity for housing the vial crown 268. The inner vial adapter upper wall 260 includes a central opening 262.

[0026] The vial crown sleeve 266 includes a first pair of longitudinal slits 252a, 252b that form a pair of vial crown holding members 254a, 254b facing each other at both ends of its diameter, and a second pair of longitudinal slits (not visible in FIG. 2). The inner vial adapter upper wall 260 preferably has a pair of notches 250a, 250b located at both ends of its diameter and facing each other radially inward of the vial crown holding members 254a, 254b so that the vial crown holding members 254a, 254b can rotate relative to the vial crown sleeve 266.

[0027] Each of the vial crown holding members 254a, 254b includes a proximal vial crown holding member 248a, 248b and a distal vial crown holding member 256a, 256b. The distal vial crown holding members 256a, 256b project radially inward so as to be snap-fitted under the vial crown 268 when the inner vial adapter body 244 is attached onto the vial 112. When a force is applied to pinch the proximal vial crown holding members 248a, 248b with pliers, the vial crown holding members 254a, 254b are rotated relative to the vial crown sleeve 266, thereby moving the distal vial crown holding members 256a, 256b radially outward.

[0028] The inner vial adapter upper wall 260 applies a force to the valve actuator 226. The valve actuator 226 extends through the outer vial adapter body 220 and the flow control body 206. The valve actuator bore 610 (see FIG. 6) formed in the flow control body 206 is substantially elongated and cylindrical. Referring to FIGS. 6 to 8, the valve actuator 226 is configured to move up and down within the valve actuator bore 610. The valve actuator 226 is configured to move within the valve actuator bore 610 between a first actuator position and a second actuator position when the vial adapter 218 is compressed.

[0029] The inner vial adapter upper wall 260 has a pair of upright members 246a, 246b located at and facing each other at both ends of a diameter orthogonal to the diameter sandwiched between a pair of vial crown retaining members 254a, 254b. The pair of upright members 246a, 246b prevent the inner vial adapter body 244 from being inadvertently removed from the outer vial adapter body 220. The vial crown sleeve 266 includes a pair of clamp members 258a, 258b located at and facing each other at both ends of a diameter orthogonal to the diameter sandwiched between a pair of vial crown retaining members 254a, 254b.

[0030] The outer vial adapter body 220 has an inverted cup shape including an outer vial adapter upper wall 230 and an outer vial adapter skirt 238. The outer vial adapter body 220 partitions an outer cavity for further accommodating the inner vial adapter body 244 when compressing the vial adapter 218 from a pre-compressed state to a compressed state.

[0031] The outer vial adapter upper wall 230 includes a central connector 222 inserted into the flow control lumen 1006 and the vial spike 242 to provide fluid communication therethrough. The corresponding flange of the outer vial adapter body 220 is received by the vial adapter flange 208. The outer vial adapter upper wall 230 includes an opening 232 for the valve actuator 226 to pass through and move.

[0032] The outer vial adapter body 220 has a pair of slits (such as slit 234) located at and facing each other at both ends of a diameter for accommodating a pair of proximal vial crown retaining members 248a, 248b, and a pair of slits located at and facing each other at both ends of a diameter for accommodating a pair of upright members 246a, 246b in the compressed state of the vial adapter 218.

[0033] The outer vial adapter skirt 238 includes a first pair of longitudinal slits 228a, 228b adjacent to each other and a second pair of longitudinal slits 236 adjacent to each other (only one slit is visible in the figure). The first pair of longitudinal slits 228a, 228b and the second pair of longitudinal slits 236 are located at both ends of the diameter of the outer vial adapter and face each other, and form a first pair of inner vial adapter holding members 240a, 240b that also face each other. As shown in FIG. 9, the tuning fork-shaped safety device 210 crosses the first pair of longitudinal slits 228a, 228b and the second pair of longitudinal slits 236 to prevent compression of the nested vial adapter.

[0034] A pair of inner vial adapter holding members 240a, 240b located at both ends of the diameter and facing each other have a pair of inner recesses 1004a, 1004b located at both ends of the diameter and facing each other (see FIG. 10), and allow movement of the inner vial adapter body 244 within the outer vial adapter body 220. A pair of inner recesses 1004a, 1004b located at both ends of the diameter and facing each other include a pair of lower recess rims 1008a, 1008b located at both ends of the diameter and facing each other (see FIG. 10). In the uncompressed state of the vial adapter 218, the pair of lower recess rims 1008a, 1008b are configured to accommodate a pair of upright members 246a, 246b to prevent the inner vial adapter body 244 from being inadvertently removed from the outer vial adapter body 220. In the compressed state of the vial adapter 218, the pair of lower recess rims 1008a, 1008b are configured to accommodate a pair of clamp members 258a, 258b for irreversibly clamping the vial adapter 218 in the compressed state.

[0035] The outer vial adapter skirt 238 has a pair of opposed openings 224 (only one opening is visible in the figure) located at opposite ends of a diameter perpendicular to the diameter between which a pair of inner vial adapter retaining members 240a, 240b are sandwiched. The pair of openings 224 are designed to facilitate the manual application of a squeezing force, like a pair of pliers, to the vial 112 using a pliers-shaped hand tool 302 (see FIG. 3) to release the non-perforated vial 112.

[0036] The vial spike 242 includes a vial spike lumen 1012 (see FIG. 10) and provides fluid communication with the vial 112 when compressed. The vial spike lumen 1012 is in fluid communication with a flow control lumen 1006 (see FIG. 10).

[0037] FIG. 3 illustrates a pliers-shaped hand tool 302 for releasing a non-perforated vial 112. The pliers-shaped hand tool 302 includes a pliers-shaped body having a pair of opposed jaws (claws) 304a, 304b, each jaw having an inwardly directed projection 306a, 306b at its end. The pair of jaws 304a, 304b can be manually forced towards each other and are used to sandwich and remove the non-perforated vial 112 by narrowing the gap like a pair of pliers.

[0038] FIG. 4 illustrates the pliers-shaped hand tool 302 together with the vial 112, the vial adapter 218, and the fluid reservoir 106.

[0039] After the user attaches the vial 112 to the liquid transfer device 110 and decides to abort the dosing before compressing the liquid transfer device 110, the non-punctured vial 112 can be reused as follows. The user aligns the pliers-like hand tool 302 with the vial adapter 218 to insert a pair of inward projections 306a, 306b into a pair of openings 224. The user compresses them with the pliers to radially bias a pair of proximal vial crown retaining members 248a, 248b inward. A pair of vial crown retaining members 254a, 254b rotate relative to the vial crown sleeve 266, thereby moving the distal vial crown retaining members 256a, 256b radially outward to release the non-punctured vial 112. The user pulls out the non-punctured vial 112 from the inner vial adapter body 244 for later use.

[0040] Figure 5 illustrates the valve 272. FIGS. 5A-5C show different perspective views of the valve 272. FIG. 5A shows a cross-section 508 of the valve 272 to illustrate the lumens 502a, 502b within the valve 272. The inclined first lumen 502a is configured to provide fluid communication between the second IV spike lumen 1010 and the flow control lumen 1006 (see FIG. 10). The linear second lumen 502b is configured to provide fluid communication between the first IV spike lumen 602 and the IV port holder lumen 606 (see FIG. 6). Thus, the fluid communication between the IV spike 202 and the vial adapter 218 is separated from the fluid communication between the IV spike 202 and the IV port holder 212. The valve 272 may further include an inclined surface 506. The valve 272 includes a locking projection 504. Depending on the configuration of the liquid transfer device 110, both the first lumen 502a and the second lumen 502b may be inclined, or the first lumen 502a may be straight and the second lumen 502b may be inclined. An inclined first lumen 502a or second lumen 502b means that the lumen includes a curved portion and changes the direction of flow from the straight-ahead direction of flow, i.e., relative to the flow path.

[0041] Referring to FIGS. 6 and 7, valve 272 is movable within valve cavity 604. Valve cavity 604 is generally cylindrical and elongated. Referring to FIGS. 6 - 8, valve 272 moves left and right in orientation within valve cavity 604 between a first position (see FIG. 6) and a second position (see FIG. 7). Prior to compression, lock projection 504 engages bore 608, thereby preventing leftward movement of valve 272. During compression, valve actuator 226 moves within valve actuator bore 610 between a first actuator position and a second actuator position as seen in FIGS. 8A and 8B. Valve actuator 226 engages inclined surface 506 of valve 272, thereby moving valve 272 to the left. When valve actuator 226 biases against inclined surface 506 of valve 272, locking projection 504 is configured to disengage from bore 608 by changing orientation so that valve 272 moves from the first position on the right side to the second position on the left side within valve cavity 604.

[0042] The valve 272 is configured to prevent fluid communication between the second IV spike lumen 1010 and the flow control lumen 1006 in a first position (or first state) corresponding to the uncompressed state of the vial adapter 218. In other words, the second IV spike lumen 1010, the first lumen 502a of the valve 272, and the flow control lumen 1006 are not in fluid communication in the first position. Similarly, the valve 272 is configured to prevent fluid communication between the first IV spike lumen 602 and the IV port holder lumen 606 in the first state. In other words, the first IV spike lumen 602, the second lumen 502b of the valve 272, and the IV port holder lumen 606 are not in fluid communication in the first state. As shown in FIG. 7, the valve 272 is configured to allow fluid communication between the first IV spike lumen 602 and the IV port holder lumen 606 in a second state (or second position) corresponding to the compressed state of the vial adapter 218. In other words, the first IV spike lumen 602, the second lumen 502b, and the IV port holder lumen 606 are in fluid communication in the second state. Similarly, the valve 272 is configured to allow fluid communication between the second IV spike lumen 1010 and the flow control lumen 1006 in the second state. In other words, the second IV spike lumen 1010, the first lumen 502a, and the flow control lumen 1006 are in fluid communication in the second state.

[0043] Accordingly, when the vial adapter 218 is in the pre-compression state, fluid communication between the IV spike 202, the vial adapter 218, and the IV port holder 212 is prevented. Upon compression of the vial adapter 218, fluid communication between the IV spike 202, the vial adapter 218, and the IV port holder 212 is permitted.

[0044] When the valve 272 rotates within the valve cavity 604 as it slides from the first state to the second state, it may disconnect the first lumen 502a from the second IV spike lumen 1010 and the flow control lumen 1006, and disconnect the second lumen 502b from the first IV spike lumen 602 and the IV port holder lumen 606. To ensure that the valve 272 maintains its rotational position during sliding, one or more devices may be provided on the outer surface of the valve 272 and / or on the inner surface of the valve cavity 604. For example, a groove may be provided on the inner surface of the valve cavity 604 and a rail (not shown) corresponding to the outer surface of the valve 272 may be provided, or vice versa.

[0045] FIG. 8 illustrates cross-sections of the liquid transfer device 110 before and after compression of the vial adapter 218. As shown in FIG. 8A, the vial adapter 218 is attached onto the vial 112. During compression, the inner vial adapter body 244 moves the valve actuator 226 from a first actuator position (see FIG. 8A) to a second actuator position (see FIG. 8B). The valve actuator 226 engages with the inclined surface 506 of the valve 272 and moves the valve 272 within the valve cavity 604 between a first position (see FIG. 8A) and a second position (see FIG. 8B).

[0046] FIG. 9 illustrates an arrangement of the liquid transfer device 110 having a safety device 210 across the outer vial adapter body 220 to prevent compression of the vial adapter 218. The vial adapter 218 is in a pre-compression state, the valve 272 is in a first position, preventing fluid communication between the IV spike 202, the IV port holder 212, and the vial 112.

[0047] FIG. 10 illustrates a cross-section of the liquid transfer device 110 coupled to the reservoir 106 and the vial 112.

[0048] FIG. 11 shows the liquid transfer device 110 after the user has attached the vial adapter 218 onto the vial 112, ready to prepare an infusion containing the drug in the infusion container 102 for subsequent administration to the patient.

[0049] FIG. 12 illustrates the liquid transfer device 110 after the user has pulled the safety device 210 out of the outer vial adapter body 220 and compressed the vial adapter 218 such that the outer vial adapter body 220 houses the inner vial adapter body 244 therein. The vial spike 242 provides fluid communication between the vial spike lumen 1012 and the vial 112 and pierces the vial stopper 270 to prepare an infusion containing the drug. Due to the compression of the vial adapter 218, the proximal vial crown retaining members 248a, 248b are no longer aligned with the opening 224, and thereafter, it is no longer possible to use the pliers-like hand tool 302 to release the vial 112 that has been pierced.

[0050] Referring to FIG. 12, the safety device 210 may be removed prior to compression of the vial adapter 218 after the inner vial adapter body 244 of the vial adapter 218 has been attached onto the vial 112. The vial adapter 218 may then be compressed from the uncompressed state to the compressed state as shown in FIG. 6. Illustrated is the spike 1202 of the infusion set 114 that can be inserted into the IV port 214 after the distal section 216b, i.e., the twist-off cap, has been removed, i.e., unscrewed.

[0051] Here, the use of the liquid transfer device 110 will be described with reference to FIGS. 3 to 12. The user (e.g., a medical professional) inserts the vial 112 into the inner vial adapter body 244 of the vial adapter 218 so that further use of the liquid transfer device 110 can be prepared. However, the user may leave the liquid transfer device 110 for later use without immediately performing the subsequent steps. Accidental compression of the vial adapter 218 of the liquid transfer device 110 is prevented by the safety device 210. When the user is ready to mix the contents of the vial 112 with the fluid in the infusion container 102, the user inserts the IV spike 202 into the intravenous administration port 108 of the infusion container 102 and removes the safety device 210. The user compresses the vial adapter by pushing the vial 112 and the inner vial adapter body 244 into the outer vial adapter body 220.

[0052] Upon compression of the vial adapter 218, the vial spike 242 punctures the sheath 264 and then punctures the vial stopper 270 to establish fluid communication between the vial spike 242 and the vial 112 to prepare an infusion containing the drug. The user prepares an infusion containing the drug in the reservoir 106 of the infusion container 102 by transferring liquid between the reservoir 106 and the vial 112 via the vial spike lumen 1012, the flow control lumen 1006, the first lumen 502a, and the second IV spike lumen 1010. To administer the infusion containing the drug, the user removes the distal section 216b of the IV port 214 and inserts the spike 1202 of the infusion set 114 therein. The prepared infusion containing the drug can be administered to the patient via the first IV spike lumen 602, the second lumen 502b, and the IV port holder lumen 606 using the infusion set 114.

[0053] While specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the present invention.

Claims

1. An IV spike configured to be connected to an infusion container, A compressible vial adapter configured to be attached onto a vial, An IV port configured to be connected to an infusion set, A valve movable between a first state and a second state upon compression of the vial adapter A liquid transfer device comprising: The IV spike Comprises a first IV spike lumen and a second IV spike lumen configured to provide fluid communication with the infusion container And The valve In the first state, prevents fluid communication between the IV spike, the vial adapter, and the IV port, In the second state, provides fluid communication between the first IV spike lumen and the vial adapter, and provides fluid communication between the second IV spike lumen and the IV port Is configured as such A liquid transfer device characterized by the above.

2. The valve Comprises a first lumen configured to provide fluid communication between the first IV spike lumen and the vial adapter, And a second lumen configured to provide fluid communication between the second IV spike lumen and the IV port The liquid transfer device according to claim 1.

3. The vial adapter Comprises a vial spike for piercing a hole in the vial stopper of the vial to provide fluid communication with the vial The liquid transfer device according to claim 1.

4. The vial adapter Comprises an outer vial adapter body and an inner vial adapter body configured to be attached onto the vial, And The inner vial adapter body is configured to slide within the outer vial adapter body when the vial adapter is subjected to compression from a non-compressed state to a compressed state. The liquid transfer device according to claim 3.

5. The vial spike is configured to pierce a hole in the vial stopper when the vial adapter is subjected to compression. The liquid transfer device according to claim 4.

6. Further comprises a valve actuator movable between a first position and a second position, And The valve actuator is configured to move from the first position to the second position upon compression of the vial adapter. The liquid transfer device according to claim 4.

7. The valve actuator When the vial adapter is compressed, move the valve from the first state when the valve actuator is in the first position to the second state when the valve actuator is in the second position. The liquid transfer device according to claim 6, which is configured as described above.

8. The valve is An inclined surface configured to engage with the valve actuator The liquid transfer device according to claim 6, which includes.

9. A safety device configured to prevent compression of the vial adapter in the non-compressed state The liquid transfer device according to any one of claims 4 to 8, which includes.

10. The IV spike, the vial adapter, and a connector body to which the IV port is coupled Further comprising The valve is movable within the connector body between the first state and the second state. The liquid transfer device according to claim 1.

11. Further comprising a bore The valve further includes a locking projection The locking projection is In the pre-compression state, engage with the bore to prevent movement of the valve between the first state and the second state. In the compressed state, change the orientation to disengage from the bore so that the valve is movable between the first state and the second state. It is configured as The liquid transfer device according to claim 10.

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