Method for manufacturing a powder-filled container

Abstract

To provide a method for manufacturing a powder-encapsulated container, which can accurately determine the presence of foreign matter in powder in a transparent container and has a low defective product rate.SOLUTION: A manufacturing method of powder-encapsulated container includes: an encapsulation step of encapsulating powder 21 in a vial 20; an inspection step to inspect foreign matter in the powder 21; and a defective product sorting step in which the vial 20 determined to contain foreign matter is regarded as a defective product. In the inspection step, while the vial 20 is vibrated via a clamp 12 that supports the vial 20, the clamp 12 is reciprocally vibrated in a vertical direction 5 and a horizontal direction 7 to allow the powder 21 in the vial 20 to flow and the flowing powder 21 is optically photographed through the vial 20, and it is determined whether or not foreign matter is present in the powder 21 based on the photographed image.SELECTED DRAWING: Figure 2

Description

Technical Field

[0001] The present invention relates to a foreign matter inspection method for inspecting whether there are foreign matters in powder in a transparent container and a method for manufacturing a powder-filled container.

Background Art

[0002] Conventionally, as a form in which powders such as injections, powders, fine granules, and granules are packaged, there are transparent containers such as vials. As an inspection for whether there are foreign matters in the powder in this transparent container, inspections by visual inspection and by analyzing image data obtained optically are known (Patent Document 1). The foreign matter detection method described in Patent Document 1 imparts a combined vibration in the vertical and horizontal directions to a transparent container filled with powder, and optically detects foreign matters in the powder.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, powders with poor fluidity do not flow while being scattered by the combined vibration, but flow as lumps. Therefore, foreign matters contained in the flowing powder do not appear on the surface of the powder lumps, and there is a problem that the foreign matter detection rate is not good. As a result, even though there are foreign matters in the powder, there is a risk of being judged as a non-defective product without foreign matters.

[0005] The present invention has been made in view of the above circumstances, and its object is to provide a method for manufacturing a powder-filled container with a low defective product rate that can accurately determine the presence of foreign matters in the powder in a transparent container.

Means for Solving the Problems

[0006] (1) The manufacturing method of the powder-filled container according to the present invention includes an encapsulation step of encapsulating powder in a transparent container, an inspection step of inspecting foreign matters in the above powder, and a defective product selection step of determining the above transparent container in which foreign matters are present as a defective product. In the above inspection step, while applying vibration to the transparent container through a support portion that supports the transparent container, a reciprocating vibration in a first direction and a reciprocating vibration in a second direction intersecting the first direction are applied to the support portion, so that the powder in the transparent container flows, the flowing powder is optically photographed through the transparent container, and it is determined whether there are foreign matters in the powder based on the photographed image.

[0007] In the inspection step, due to the vibration applied through the support portion, the lumps of powder in the transparent container collapse and the powder is likely to scatter. Due to the reciprocating vibration in the first direction and the reciprocating vibration in the second direction, the powder flows in a circulating manner in the transparent container. As a result, in the transparent container, the powder flows while scattering, so in the inspection step, foreign matters in the powder are likely to be exposed and foreign matters are likely to appear in the photographed image. And in the defective product selection step, since the transparent container in which foreign matters are determined to be present is regarded as a defective product, the foreign matter mixing rate of the manufactured powder-filled container is low.

[0008] (2) Preferably, the above transparent container has a container body having a mouth portion, a side wall continuous with the mouth portion, and a bottom continuous with the side wall, and a lid plugged into the mouth portion. In the above encapsulation step, the lid is plugged into the container body that stores the above powder.

[0009] In the powder encapsulated in the transparent container, foreign matter mixing is accurately inspected, and a powder-filled container with a low foreign matter mixing rate is manufactured.

[0010] (3) Preferably, in the above inspection step, the first direction and the second direction are orthogonal to each other, the support portion supports the third direction in which the mouth portion and the bottom portion face each other so as to be orthogonal to the first direction and the second direction, and the flowing powder is photographed through the side wall.

[0011] Since the powder accumulated on the bottom side of the transparent container flows along the side wall, foreign matters in the powder are likely to be exposed, and foreign matters are likely to appear in the captured image.

[0012] (4) Preferably, in the third direction, with the mouth portion being above the bottom portion, it is inclined with respect to the horizontal direction.

[0013] Since the powder flowing along the side wall of the transparent container is located on the bottom side, the range for taking an image is likely to be limited.

[0014] (5) Preferably, in the inspection step, the flowing powder is photographed from below the transparent container.

[0015] Since the state where the powder that has fallen by gravity while flowing in the transparent container collides with the reciprocally vibrating transparent container is photographed, foreign matters are likely to appear in the captured image.

[0016] (6) Preferably, the angle of repose of the powder is in the range of 30 degrees to 60 degrees.

Advantages of the Invention

[0017] According to the present invention, since the presence of foreign matters in the powder in the transparent container can be accurately determined, a powder-filled container with a low foreign matter mixing rate can be obtained.

Brief Description of the Drawings

[0018]

Figure 1

Figure 2

Figure 3

Figure 4

Embodiments for Carrying Out the Invention

[0019] Hereinafter, embodiments of the present invention will be described with reference to the drawings as appropriate. It should be noted that the embodiments described below are merely examples of the present invention, and it goes without saying that the embodiments of the present invention can be appropriately changed without changing the gist of the present invention. In the following description, an up-down direction 5 is defined based on up and down, a front-back direction 6 (a direction perpendicular to the plane of FIG. 2) is defined in a direction perpendicular to the up-down direction 5, and a left-right direction 7 is defined in a direction perpendicular to each of the up-down direction 5 and the front-back direction 6.

[0020] [Vial 20 and powder 21] As shown in FIG. 1, the object to be inspected by the foreign matter inspection apparatus 10 described later is a vial 20 (an example of a transparent container and a powder-filled container) containing powder 21. Although not shown, the vial 20 is sealed by winding and tightening a lid 22 and a container body 23 with an aluminum cap, for example, by a known method. The powder 21 is a drug such as an injection, a powder, a fine granule, or a granule. The drug is not particularly limited, but for example, an antibiotic of the cell wall synthesis inhibitory action type, an antibiotic of the cell membrane inhibitory action type, an antibiotic of the nucleic acid synthesis inhibitory action type, an antibiotic of the protein synthesis inhibitory action type, an antibiotic of the folic acid metabolism pathway inhibitory type, a β-lactamase inhibitor, a sulfonamide, and an anti-infective agent are preferable. Further, as drugs, ampicillin, bacampicillin, amoxicillin, pivmecillinam, amoxicillin, sultamicillin, piperacillin, azlocillin, benzylpenicillin, cloxacillin, oxacillin, carbenicillin, cephaloclor, cefuroxime, cephradroxil, cefixime, cefotiam pivoxil, cefuroxime axetil, cefpodoxime proxetil, cefotiam hexetil, cefdinir, cefibutene, cefditoren pivoxil, cefcapene pivoxil, cefazolin, cefozopran, cefmetazole, cefotiam, cefurosine, cefoperazone, cefotaxime, cefmenoxime, ceftriaxone, ceftazidime, cefodizime, cefpirome, cefepime, faropenem, imipenem, panipenem, meropenem, biapenem, doripenem, aztreonam, vancomycin, teicoplanin, fosmidomycin, polymyxin B sulfate, colistin sulfate, gramicidin S, amphotericin B, levofloxacin, ofloxacin, norfloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, gatifloxacin, prulifloxacin, moxifloxacin, pazufloxacin, rifampicin, dibekacin, tobramycin, amikacin, isepamicin, micronomicin, streptomycin, kanamycin, gentamicin, erythromycin, rokitamycin, josamycin, roxithromycin, clarithromycin, azithromycin, telithromycin, doxycycline, minocycline, chloramphenicol, lincomycin, clindamycin, trimethoprim, clavulanic acid,Sulbactam, tazobactam, sulfamethoxazole, salazopyrin, isoniazid, rifampicin, pyrazinamide, ethambutol, gliocladin, amphotericin B, 5-fluorocytosine, fluconazole, miconazole, itraconazole, acyclovir, ganciclovir, phosphonoformic acid, idoxuridine, amantadine, interferon γ, ribavirin, lamivudine, metronidazole, tinidazole, fluconazole, mebendazole, pyrantel pamoate, diethylcarbamazine, praziquantel, albendazole, ivermectin, quinupristin, dalfopristin, linezolid, spectinomycin, netilmicin, sisomycin, lincosamin, ramoplanin, telithromycin, nystatin, fusidic acid, chlorhexidine, and polyhexanid, etc. can be mentioned.

[0021] Examples of the characteristics of the powder 21 include, for example, the angle of repose, particle size, filling amount, and bulk density. Specifically, the angle of repose of the powder 21 is in the range of 30 degrees to 60 degrees, preferably in the range of 33 degrees to 60 degrees. Specifically, the particle size of the powder 21 is such that the average particle diameter (median diameter: d50) is in the range of 20 μm to 70 μm, preferably in the range of 21.1 μm to 55.7 μm. The filling amount of the powder 21 accommodated in the vial 20 is at least 0.25 g or more, and even if the filling amount is large, it is possible to be inspected by the foreign matter inspection device 10. Specifically, the bulk density of the powder 21 is in the range of 0.300 g / mL to 0.700 g / mL, preferably in the range of 0.340 g / mL to 0.670 g / mL.

[0022] As shown in FIG. 1, the vial 20 (an example of a transparent container) has a lid 22 and a container body 23. The lid 22 is formed from a resin such as rubber or elastomer. The container body 23 is, for example, made of transparent glass. The container body 23 only needs to have a light transmittance such that the powder 21 in the internal space can be optically photographed by the photographing device 15 (see FIG. 2).

[0023] The container body 23 has a mouth portion 24 that forms an opening leading to the internal space, a side wall 25, and a bottom portion 26. The container body 23 is generally cylindrical as a whole and is a so-called narrow-mouth container in which the outer diameter of the mouth portion 24 is smaller than the outer diameter of the side wall 25. The mouth portion 24 and the bottom portion 26 face each other. The bottom portion 26 is disk-shaped, and the container body 23 stands upright with the bottom portion 26 placed on a desk or the like and the opening formed by the mouth portion 24 facing upward. The side wall 25 is cylindrical. The mouth portion 24 is continuous with the side wall 25. The mouth portion 24 has a shape in which the outer diameter gradually expands toward the side wall 25. The side wall 25 and the bottom portion 26 are continuous. The outer diameter of the side wall 25 and the outer diameter of the bottom portion 26 are equal.

[0024] The lid 22 has a shape in which a convex portion that enters and fits into the opening formed by the mouth portion 24 protrudes from a disk that is in close contact with the mouth portion 24. For example, the container body 23 is filled with the powder 21 by a filling machine, the lid 22 is plugged into the mouth portion 24, and an aluminum cap is tightened, so that the container body 23 is sealed.

[0025] [Foreign matter inspection device 10] The foreign matter inspection device 10 inspects whether foreign matter is mixed in the powder 21 enclosed in the vial 20. As shown in FIG. 2, the foreign matter inspection device 10 includes a frame 11, a clamp 12 (an example of a support portion), a vibration generator 13, a synthetic vibration generator 14, a photographing device 15, an analysis device 16, and an illumination device 17. The support portion 12, the vibration generator 13, the synthetic vibration generator 14, and the photographing device 15 are supported by the frame 11. The frame 11 can change its posture so that the front-rear direction 6 inclines from the horizontal direction while supporting the support portion 12, the vibration generator 13, the synthetic vibration generator 14, and the photographing device 15. The analysis device 16 is connected to the photographing device 15 so as to be capable of data communication.

[0026] The clamp 12 is divided into a pair in the left - right direction 7, and by moving in the left - right direction 7 respectively, it changes between a state of clamping the vial 20 and a state of not clamping the vial 20. The clamp 12 clamps the side wall 25 of the vial 20 from the left - right direction 7. In the state where the clamp 12 clamps the vial 20, the direction in which the mouth part 24 and the bottom part 26 face each other (an example of the third direction), that is, the axial direction of the container body 23, is parallel to the front - back direction 6. Also, in the state where the clamp 12 clamps the vial 20, a part of the side wall 25 of the vial 20 is exposed in the up - down direction 5.

[0027] The vibration generating device 13 is fixed at a position where it does not contact the vial 20 in each of the pair of clamps 12. The vibration generating device 14 generates vibration, for example, by the rotation of an eccentric motor. The vibration generated by the vibration generating device 13 is transmitted to the vial 20 through the clamp 12.

[0028] The combined vibration generating device 14 imparts a reciprocating vibration in the up - down direction 5 (an example of the first direction) and a reciprocating vibration in the left - right direction 7 (an example of the second direction) to the clamp 12. The combined vibration generating device 14 includes a motor 40, an up - down vibration generating mechanism 41, and a left - right vibration generating mechanism 42. The motor 40 generates a driving force that is transmitted to the up - down vibration generating mechanism 41 and the left - right vibration generating mechanism 42.

[0029] The up - down vibration generating mechanism 41 includes an eccentric disk cam 43, a cam shaft 44, a link arm 45, and a slider 46. The eccentric disk cam 43 is supported rotatably on a cam shaft 44 that is supported by the frame 11 and extends along the front - back direction 6. The cam shaft 44 is provided with the eccentric disk cam 43. The eccentric disk cam 43 protrudes radially from the cam shaft 44. The length by which the eccentric disk cam 43 protrudes from the cam shaft 44 continuously changes in the circumferential direction of the cam shaft 44.

[0030] The link arm 45 is slidably fitted to the eccentric disk cam 43. As the rotation of the eccentric disk cam 43 is transmitted to the link arm 45, the position of the link arm 45 rotates while being displaced in the vertical direction 5. The link arm 45 is connected to the slider 46 via the shaft 47. The slider 46 is movable along the vertical direction 5 by fitting with a slide rail 54 provided on the slider 51 of the left - right oscillation generating mechanism 42. Therefore, the slider 46 reciprocates in the vertical direction 5 depending on the moving width in the vertical direction 5 during the rotation of the link arm 45.

[0031] The link arm 45 has a support arm 55 extending along the left - right direction 7. The support arm 55 supports the clamp 12 and the vibration generating device 14.

[0032] The left - right oscillation generating mechanism 42 has an eccentric disk cam 48, a cam shaft 49, a link arm 50, and a slider 51. The eccentric disk cam 48 is supported by the frame 11 and is rotatably supported on a cam shaft 49 extending along the front - rear direction 6. The cam shaft 49 is provided with the eccentric disk cam 48. The eccentric disk cam 48 protrudes radially from the cam shaft 49. The length by which the eccentric disk cam 48 protrudes from the cam shaft 49 continuously changes in the circumferential direction of the cam shaft 49.

[0033] The link arm 50 is slidably fitted to the eccentric disk cam 48. As the rotation of the eccentric disk cam 48 is transmitted to the link arm 50, the position of the link arm 50 rotates while being displaced in the left - right direction 7. The link arm 50 is connected to the slider 51 via the shaft 52. The slider 51 is movable along the left - right direction 7 by fitting with a slide rail 53 provided on the frame 11. Therefore, the slider 51 reciprocates in the left - right direction 7 depending on the moving width in the left - right direction 7 during the rotation of the link arm 50.

[0034] At the left end of the slider 51, a slide rail 54 extending in the vertical direction 5 is formed. The slide rail 54 is fitted with the slider 46 of the vertical vibration generating mechanism 41. Through the slide rail 54, the reciprocating movement of the slider 51 in the left - right direction 7 is transmitted to the slider 46. As a result, the slider 46 reciprocates in the left - right direction 7 and also reciprocates in the vertical direction 5. That is, the combined vibration of the reciprocating movement in the left - right direction 7 and the reciprocating movement in the vertical direction 5 is transmitted to the support arm 55.

[0035] Assuming that the amplitude of the reciprocating movement in the vertical direction 5 by the vertical vibration generating mechanism 41 and the amplitude of the reciprocating movement in the left - right direction 7 by the left - right vibration generating mechanism 42 are the same, by adjusting the phase difference of the eccentric disk cams 43, 48, the combined vibration becomes either circular motion, linear motion, or elliptical motion. For example, the phase difference of the eccentric disk cams 43, 48 is set so that the combined vibration becomes elliptical motion.

[0036] The photographing device 15 is installed below the clamp 12. The photographing device 15 is a camera that optically photographs the powder 21 in the vial 20 through a part of the side wall 25 exposed in the vertical direction 5 in the vial 20 held by the clamp 12. The photographing device 15 photographs a plurality of images of the vibrating vial 20 at a frame rate of, for example, 30 frames per second or 60 frames per second for a predetermined time.

[0037] The analysis device 16 is a computer installed with determination software that analyzes the images photographed by the photographing device 15 to determine whether foreign matter is mixed in the powder 21. The analysis device 16 is connected to the photographing device 15 so as to be able to transmit and receive data. The analysis device 16 has, for example, an input device such as a keyboard and a mouse, and a display device such as a display. The image received from the photographing device 15 may be displayed on the display of the analysis device 16.

[0038] The determination software determines whether foreign matter is mixed in the powder 21 of the vial 20 based on the image of the vial 20 taken by the imaging device 15, that is, the image data. Specifically, one obtained piece of image data is regarded as regions subdivided into a predetermined number of vertical and horizontal sections, and the color density of each region is identified in multiple levels. If the powder 21 is white, foreign matter is recognized as black. Then, it is determined whether foreign matter exists from the peak value (color density of foreign matter) and the intensity area value (vertical × horizontal of foreign matter) in the image data. For example, if both the peak value and the intensity area value are within predetermined conditions, for example, if each value is equal to or greater than a threshold value and there is a continuous predetermined range, it is determined that foreign matter exists in the powder 21 of the vial 20. Note that the detectable foreign matter is not particularly limited as long as it appears in the image with a brightness different from that of the powder 21.

[0039] The lighting devices 17 are respectively installed above and below the clamp 12. The two lighting devices 17 irradiate light on the vial 20 held and vibrating by the clamp 12 from respective directions in the vertical direction 5. The lighting device 17 located below the clamp 12 does not overlap with the region where the imaging device 15 and the clamp 12 face each other, and is at a position offset in the front-rear direction 6 with respect to the region.

[0040] [Manufacturing method of vial 20 filled with powder 21] Hereinafter, a manufacturing method of the vial 20 filled with the powder 21 will be described. The manufacturing method of the vial 20 includes the following plurality of steps. (1) An encapsulation step of encapsulating the powder 21 in the vial 20. (2) An inspection step of inspecting for foreign matter in the powder 21 (an example of an inspection method). (3) A defective product sorting step of designating as defective products the vials 20 in which foreign matter is determined to exist in the powder 21.

[0041] In the encapsulation step, the powder 21 is filled into the container body 23 by a screw feeder. Then, a lid 22 is plugged onto the container body 23 that stores the powder 21, and an aluminum cap is tightened so as to seal the boundary between the lid 22 and the container body 23. Thereby, a vial 20 in which the powder 21 is sealed in the internal space is obtained.

[0042] The inspection process is performed using the foreign object inspection device 10. The vial 20 with the powder 21 sealed in the internal space is clamped by the clamp 12 of the foreign object inspection device 10. The axial direction C (see FIG. 3) of the vial 20 clamped by the clamp 12 is parallel to the front-rear direction 6.

[0043] When the foreign object inspection device 10 is operated, the frame 11 tilts. As shown in FIG. 3, when the frame 11 tilts, the axial direction C of the vial 20 tilts with respect to the front-rear direction 6 (horizontal direction) with the mouth 24 of the container body 23 above the bottom 26. The tilt angle is within the range of 0 degrees to 15 degrees, preferably within the range of 1 degree to 10 degrees. When the foreign object inspection device 10 is operated, the lighting device 17 is turned on.

[0044] After the frame 11 tilts, the vibration generator 13 is operated and the motor 40 is operated. When the vibration generator 13 is operated, vibration is applied to the vial 20 clamped by the clamp 12. When vibration is applied to the vial 20, even if the powder 21 adheres to the side wall 25 in the vial 20, the powder 21 is separated from the side wall 25 by the vibration. Also, the lumps of the powder 21 break up. As a result, foreign objects mixed in the powder 21 are likely to appear on the inner surface side of the side wall 25 of the vial 20.

[0045] When the motor 40 is operated, a combined vibration that becomes an elliptical motion as viewed from the front-rear direction 6 is applied to the vial 20 by the combined vibration generator 14. Due to this combined vibration, in the internal space of the vial 20, as shown in FIG. 4, the powder 21 flows while circulating in an ellipse. In the flow of this powder 21, foreign objects having different sizes and weights from each particle of the powder 21 have a different flow from the powder 21. For example, foreign objects heavier than each particle of the powder 21 tend to move to the outside of the circulation of the flowing powder 21, so they are likely to appear on the inner surface side of the side wall 25 of the vial 20.

[0046] In addition, since the axial direction C of the vial 20 is inclined with respect to the front-rear direction 6 such that the mouth portion 24 of the container body 23 is above the bottom portion 26, the powder 21 tends to accumulate on the bottom portion 26 side. Further, since foreign matter heavier than each particle of the powder 21 tends to move to the bottom portion 26 side rather than the powder 21, it is likely to appear on the inner surface side of the side wall 25 near the bottom portion 26 of the vial 20.

[0047] Based on an image of the vial 20 taken by the imaging device 15 when vibration and combined vibration are applied to the vial 20, the analysis device 16 determines whether there is foreign matter in the powder 21 inside the vial 20.

[0048] In the defective product sorting process, the vial 20 determined to have foreign matter in the powder 21 is excluded from the shipment targets as defective products.

[0049] [Operation and Effect of Embodiment] According to the above-described embodiment, in the inspection process, due to the vibration applied via the clamp 12, the mass of the powder 21 in the vial 20 collapses or the powder 21 separates from the side wall 25, making it easier for the powder 21 to scatter. Further, due to the combined vibration in the vertical direction 5 and the horizontal direction 7, the powder 21 flows in a circulating manner inside the vial 20. As a result, inside the vial 20, the powder 21 scatters and flows, so that in the inspection process, foreign matter in the powder 21 is likely to be exposed and appear in the captured image. Then, in the defective product sorting process, since the vial 20 determined to have foreign matter is regarded as a defective product, the foreign matter mixing rate of the manufactured vials 20 is low.

[0050] In addition, in the inspection process, since the axial direction C of the vial 20 is supported parallel to the front-rear direction 6, the flowing powder 21 is imaged through the side wall 25 of the vial 20.

[0051] Also, in the inspection process, since the axial direction C of the vial 20 is inclined from the front-rear direction 6, the powder 21 accumulated on the bottom 26 side of the vial 20 flows along the side wall 25. As a result, foreign matters in the powder 21 are likely to be exposed, and foreign matters are likely to appear in the captured image. Also, since foreign matters are likely to appear near the bottom 26 of the side wall 25 of the vial 20, the range for capturing an image for foreign matter determination is limited.

[0052] Also, in the inspection process, since the flowing powder 21 is photographed from below the vial 20, a state where the powder 21 that has fallen due to gravity while flowing inside the vial 20 collides with the side wall 25 of the vibrating container body 23 is photographed. As a result, foreign matters are likely to appear in the captured image.

Description of Signs

[0053] 10 ··· Foreign matter inspection device 11 ··· Frame 12 ··· Clamp (support part) 13 ··· Vibration generator 14 ··· Composite vibration generator 15 ··· Photographing device 16 ··· Analysis device 20 ··· Vial 21 ··· Powder 22 ··· Cap 23 ··· Container body 24 ··· Mouth part 25 ··· Side wall 26 ··· Bottom

Claims

【Claim 1】 An encapsulation step of encapsulating powder in a transparent container; An inspection step of inspecting foreign matter in the powder; A defective product sorting step of determining the transparent container in which foreign matter is present as a defective product, the method for manufacturing a powder-encapsulated container including: The transparent container has a container body having a mouth portion, a side wall continuous with the mouth portion, and a bottom portion continuous with the side wall, and a lid plugged into the mouth portion; The angle of repose of the powder is in the range of 30 degrees to 60 degrees; The average particle size of the powder is in the range of 20 μm to 70 μm; In the encapsulation step, the lid is plugged onto the container body for storing the powder; The inspection step is: A support portion for supporting the transparent container makes the third direction in which the mouth portion and the bottom portion face each other perpendicular to the first direction and the second direction perpendicular to the first direction, intersects with the vertical direction, and the mouth portion is inclined with respect to the horizontal direction above the bottom portion. While supporting, a combined vibration of a reciprocating vibration in the first direction and a reciprocating vibration in the second direction is applied to the support portion to fluidize the powder in the transparent container, and a vibration different from the combined vibration is applied to the transparent container through the support portion; While irradiating the flowing powder with illumination from above and below the transparent container, the side wall of the transparent container is optically photographed from below the transparent container; The photographed image is divided into regions subdivided vertically and horizontally by a predetermined number, the black and white densities are identified in multiple levels in each region, and whether there is a continuous predetermined range in the vertical or horizontal direction where each region where the identified black and white density is equal to or greater than the threshold value recognized as black exists. A method for manufacturing a powder-encapsulated container for determining whether there is foreign matter in the powder based on this.

Images