Blood purification device

Abstract

To provide a blood purification device capable of reducing an amount of a priming liquid to be administrated together with an anticoagulant when administering the anticoagulant to a patient before blood purification treatment.SOLUTION: A blood purification device including a control unit for controlling a blood pump 4 and an infusion pump 5 is such that the control unit 9 supplies a driving signal to the infusion pump 5 to drive the infusion pump 5 in a state that a blood circuit is filled with a priming liquid, supplies a first driving signal to the blood pump 4 to perform first driving of the blood pump 4 in a state that an anticoagulant is infused to the blood circuit by driving of the infusion pump 5, and supplies a second driving signal to the blood pump 4 in a state that the anticoagulant is transferred to the tip of an artery side blood circuit 1 and / or the tip of a vein side blood circuit 2 by the first driving of the blood pump 4, and the tip of the artery side blood circuit 1 and the tip of the vein side blood circuit 2 are punctured to a patient.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial-side blood circuit and a venous-side blood circuit and a blood purifier to purify the blood.

Background Art

[0002] A dialysis device as a blood purification device used in dialysis treatment or the like usually has a piping section having a dialysis fluid introduction line for introducing dialysis fluid into a blood purifier and a drainage discharge line for discharging drainage from the blood purifier, and a liquid feeding section for feeding the dialysis fluid and drainage in the piping section, and is configured by connecting a blood circuit for extracorporeally circulating a patient's blood to the blood purifier, and is configured to perform dialysis treatment (blood purification treatment) with the blood purifier while extracorporeally circulating the patient's blood in the blood circuit.

[0003] On the other hand, when extracorporeally circulating a patient's blood in blood purification treatment, it is necessary to previously administer an anticoagulant to the patient in order to avoid blood coagulation. However, in order to sufficiently exhibit the blood coagulation inhibitory effect of the anticoagulant, it has been necessary to perform blood purification treatment after a predetermined time (for example, about 3 to 5 minutes) has elapsed since the anticoagulant was administered to the patient. For this reason, conventionally, as disclosed in Patent Document 1, a blood purification device has been proposed in which, after injecting an anticoagulant into a blood circuit, the anticoagulant is administered into the patient's body together with a priming solution, and blood purification treatment is performed after a predetermined time has elapsed.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the above-described conventional blood purification apparatus, when administering an anticoagulant into a patient's body, for example, when there is a relatively long flow path from the injection position of the anticoagulant to the patient, an excessive amount of priming liquid corresponding to the priming volume of the flow path is administered into the patient's body together with the anticoagulant. Since patients who require blood purification treatment are usually in a state of fluid overload, it is not desirable to administer an excessive amount of priming liquid to such patients in a fluid overload state.

[0006] The present invention has been made in view of such circumstances, and an object thereof is to provide a blood purification apparatus capable of reducing the amount of priming liquid administered together with an anticoagulant when administering the anticoagulant to a patient before blood purification treatment.

Means for Solving the Problems

[0007] A blood purification apparatus according to an embodiment of the present invention is a blood purification apparatus that extracorporeally circulates a patient's blood through a blood circuit having an arterial side blood circuit and a venous side blood circuit and a blood purifier to purify the blood, including a blood pump that causes the blood in the blood circuit to flow and extracorporeally circulate, an injection pump that injects an anticoagulant at a predetermined site, The anticoagulant injection line to which the injection pump is connected, a control unit that controls the blood pump and the injection pump, and in a state where the blood circuit is filled with a priming liquid, the control unit supplies a drive signal to the injection pump to drive the injection pump, and in a state where the anticoagulant is injected into the blood circuit by the drive of the injection pump, supplies a first drive signal to the blood pump to first drive the blood pump, and by the first drive of the blood pump flow the priming liquid in an amount equal to the volume from the connection part of the anticoagulant injection line in the blood circuit to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit, the anticoagulant to is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit carry out and is configured to supply a second drive signal to the blood pump in a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient.

Advantages of the Invention

[0008] According to the present invention, in a state where a priming solution is filled in a blood circuit, a drive signal is supplied to an infusion pump to drive the infusion pump, and in a state where an anticoagulant is injected into the blood circuit by driving the infusion pump, a first drive signal is supplied to a blood pump to first drive the blood pump, and the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit by the first drive of the blood pump. In a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into a patient, a second drive signal is supplied to the blood pump. Therefore, when administering an anticoagulant to a patient before blood purification treatment, the amount of the priming solution administered together with the anticoagulant can be reduced.

Brief Description of the Drawings

[0009]

Figure 1

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Figure 16

Mode for Carrying Out the Invention

[0010] Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings. The blood purification device according to the present embodiment extracorporeally circulates the patient's blood through a blood circuit having an arterial side blood circuit and a venous side blood circuit and a blood purifier, and purifies the blood. As shown in FIG. 1, it includes a blood circuit having an arterial side blood circuit 1 and a venous side blood circuit 2, a dialyzer 3 as a blood purifier, a blood pump 4, an infusion pump 5, a dialysis device main body 8 capable of supplying dialysis fluid to the dialyzer 3, and a control unit 9.

[0011] The arterial side blood circuit 1 has a connector 1a connected to its tip, and an arterial side puncture needle a (see FIGS. 7 and 8) can be connected via the connector 1a. A squeezing type blood pump 4 is disposed in the middle. The blood pump 4 is composed of a pump disposed at a predetermined position of the arterial side blood circuit 1 and is for flowing the blood and the priming fluid in the blood circuit by driving.

[0012] On one hand, the venous blood circuit 2 has a connector 2a connected to its tip, and a venous puncture needle b (see FIGS. 7 and 8) can be connected via the connector 2a. An air trap chamber 6 is connected in the middle. The air trap chamber 6 consists of a chamber connected to a predetermined position of the venous blood circuit 2 and is for capturing and removing air contained in the blood undergoing extracorporeal circulation.

[0013] Clamping means K1 and K2 each composed of electromagnetic valves are respectively disposed at the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2. By setting the clamping means K1 and K2 to the open state, the flow path at the tip of the arterial blood circuit 1 or the venous blood circuit 2 can be opened, and by setting the clamping means K1 and K2 to the closed state, the flow path at the tip of the arterial blood circuit 1 or the venous blood circuit 2 can be blocked.

[0014] The dialyzer 3 (blood purifier) has a blood inlet 3a (blood introduction port), a blood outlet 3b (blood discharge port), a dialysate inlet 3c (dialysate introduction port), and a dialysate outlet 3d (dialysate discharge port) formed in its housing portion. Among these, the arterial blood circuit 1 is connected to the blood inlet 3a, and the venous blood circuit 2 is connected to the blood outlet 3b respectively. Also, the dialysate inlet 3c and the dialysate outlet 3d are respectively connected to a dialysate introduction line L1 and a drainage discharge line L2.

[0015] A plurality of hollow fiber membranes (not shown) are accommodated in the dialyzer 3, and this hollow fiber membrane constitutes a blood purification membrane for purifying blood. And a large number of minute holes (pores) penetrating the outer peripheral surface and the inner peripheral surface are formed in the hollow fiber membrane constituting the blood purification membrane to form the hollow fiber membrane, and impurities in the blood can permeate into the dialysate through the hollow fiber membrane for purification.

[0016] The dialysis apparatus main body 8 is provided with a dialysis fluid introduction line L1 for introducing dialysis fluid into the dialyzer 3 and a drainage discharge line L2 for discharging drainage from the dialyzer 3. One end of the dialysis fluid introduction line L1 is connected to the dialyzer 3 (dialysis fluid inlet 3c), and the other end is connected to a dialysis fluid creating means (not shown) for preparing dialysis fluid of a predetermined concentration, so that dialysis fluid of a predetermined concentration can be introduced into the dialyzer 3.

[0017] Also, one end of the drainage discharge line L2 is connected to the dialyzer 3 (dialysis fluid outlet 3d), and the other end is connected to drainage means (not shown). After the dialysis fluid supplied from the dialysis fluid supply device reaches the dialyzer 3 through the dialysis fluid introduction line L1, the drainage from the dialyzer 3 is sent to the drainage means through the drainage discharge line L2. Note that the dialysis apparatus main body 8 is provided with a liquid feed pump for flowing the dialysis fluid and the drainage, and a water removal pump (not shown) for removing moisture from the patient's blood flowing through the dialyzer 3.

[0018] However, when the blood pump 4 is driven with the arterial side puncture needle a connected to the tip of the arterial side blood circuit 1 and the venous side puncture needle b connected to the tip of the venous side blood circuit 2 punctured into the patient, the patient's blood reaches the dialyzer 3 through the arterial side blood circuit 1, and after undergoing blood purification treatment by the dialyzer 3, it returns to the patient's body through the venous side blood circuit 2. Thus, the patient's blood can be purified by the dialyzer 3 while being extracorporeally circulated through the blood circuit.

[0019] In the arterial blood circuit 1 according to this embodiment, a raw solution line L3 is connected at a position between the connector 1a and the installation site of the blood pump 4, and a storage container 7 containing a predetermined amount of priming solution (physiological saline) is connected to the tip thereof. A clamp means K3 composed of an electromagnetic valve is disposed in such a raw solution line L3. By opening the clamp means K3 to open the raw solution line L3, the priming solution in the storage container 7 can be supplied to the blood circuit, and by closing the raw solution line L3 in the closed state, the supply of the priming solution to the blood circuit side can be stopped.

[0020] Furthermore, in the arterial blood circuit 1 according to this embodiment, an anticoagulant injection line L4 is connected between the installation site of the blood pump 4 and the connection site of the dialyzer 3, and a syringe M containing a predetermined amount of anticoagulant (heparin H in this embodiment) is connected to the tip thereof. Such a syringe M is attached to an injection pump 5 disposed in the dialysis apparatus main body 8, and by sliding the plunger of the syringe M with a pusher (not shown) provided in the injection pump 5, a predetermined amount of the anticoagulant contained therein can be injected.

[0021] Heparin H as an anticoagulant is composed of, for example, unfractionated heparin and low molecular weight heparin, etc., and is initially administered before blood purification treatment (before dialysis treatment), and is continuously administered (continuously administered) as necessary during the blood purification treatment process. Note that instead of heparin, other types of anticoagulants that can exhibit an anticoagulant effect may be injected and administered.

[0022] In this embodiment, the volume between the connection part of the anticoagulant injection line L4 and the tip of the arterial blood circuit 1 is 45.1 (ml), and the flow rate of the blood pump 4 is 8.696 (ml / revolution). On this premise, in the transfer process described later, by rotating the blood pump 4 about 6 revolutions (52.2 (ml)) in the reverse direction, the heparin H can be transferred from the anticoagulant injection line L4 to the vicinity of the tip of the venous blood circuit 2. In the administration process described later, after connecting to the patient, by rotating the blood pump 4 about 2 revolutions (17.4 (mL)) in the forward direction, the heparin H can be administered from the venous blood circuit 2 to the patient. Note that the volume of the blood circuit varies depending on the type of the device, so it is necessary to check in advance and set it for the device. Also, regarding the adjustment of the required number of revolutions in the transfer process and the administration process, it is necessary to confirm in advance by experiment how much the heparin H diffuses in the transfer process.

[0023] The control unit 9 is composed of a microcomputer or the like (specifically, the microcomputer 9a shown in FIG. 10) disposed in the dialysis device main body 8, and is electrically connected to the blood pump 4, the injection pump 5, and further the clamp means (K1 to K3). It is capable of controlling the driving of these blood pump 4 and injection pump 5 and the operation of the clamp means (K1 to K3) to execute a priming process of filling the blood circuit with a priming liquid and a blood purification treatment process of purifying the blood with the dialyzer 3 while circulating the patient's blood outside the body in the blood circuit.

[0024] Here, the control unit 9 according to this embodiment is capable of sequentially executing, after the priming process, an injection process of driving the injection pump 5 to inject an anticoagulant (heparin H) into the blood circuit, a transfer process of driving the blood pump 4 to transfer the heparin H injected in the injection process to the tips of the arterial blood circuit 1 and the venous blood circuit 2, an administration process of driving the blood pump 4 with the tips of the arterial blood circuit 1 and / or the venous blood circuit 2 punctured to the patient to administer the heparin H transferred in the transfer process to the patient, and a standby process of waiting until a predetermined time elapses after the administration process.

[0025] Next, the control by the control unit 9 according to the present embodiment will be described based on the flowcharts of FIGS. 2 and 3. First, as shown in FIG. 4, after forming a closed circuit by connecting the connector 1a at the tip of the arterial blood circuit 1 and the connector 2a at the tip of the venous blood circuit 2 to each other, while the clamp means K3 is in the open state, the blood pump 4 is driven (forward drive), thereby executing a priming step S1 of guiding and filling the priming liquid (physiological saline) in the storage container 7 into the blood circuit. In the priming step S1, the priming liquid in the storage container 7 circulates in the closed circuit composed of the arterial blood circuit 1 and the venous blood circuit 2, and is discharged to the outside through the overflow line La extending from the upper part of the air trap chamber 6, thereby being filled in the closed circuit. However, the priming method is not limited to this, and various priming methods may be used in the priming step.

[0026] After the priming step S1, the process proceeds to an administration preparation step S2. In the administration preparation step S2, as shown in FIG. 3, at S201, the first electromagnetic valve and the second electromagnetic valve (clamp means K1, K2) are opened, the third electromagnetic valve (clamp means K3) is closed, and at S202, a drive signal is transmitted to the actuator P2 of the injection pump 5 to drive the injection pump 5 (FIG. 5). Then, when a first drive signal is transmitted to the actuator P1 of the blood pump 4 at S203, as shown in FIG. 6, the blood pump 4 is driven to transfer the heparin H (transfer step). Then, while the first and second electromagnetic valves (clamp means K1, K2) are closed at S204, the closed state of the third electromagnetic valve (clamp means K3) is maintained (see FIG. 7), and at S205, it is determined whether a signal notifying that the punctures at the tips of the arterial blood circuit 1 and the venous blood circuit 2 are completed has been received.

[0027] When it is determined that a signal notifying the completion of the punctures at the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2 has been received in S205, the process proceeds to the administration step S3. As shown in FIG. 8, in the administration step S3, with the arterial puncture needle a and the venous puncture needle b puncturing the patient, the clamp means K1 is in the closed state, the clamp means K2 is in the open state, and the clamp means K3 is in the open state, and the blood pump 4 is driven forward to administer heparin H at the tip of the venous blood circuit 2 (near the connector 2a) into the patient's body through the venous puncture needle b. Note that the amount of heparin H administered in the administration step S3 can be estimated based on the rotation speed of the blood pump 4.

[0028] After the administration step S3, a standby step S4 is executed in which the driving of the blood pump 4 and the infusion pump 5 is stopped and the system waits until a predetermined time (for example, about 3 to 5 minutes) has elapsed. By waiting until the predetermined time has elapsed in such a standby step S4, the heparin H administered into the patient's body can be activated to sufficiently enhance the blood coagulation inhibitory effect, and when the patient's blood is extracorporeally circulated in the subsequent blood purification treatment step S5, blood coagulation can be suppressed.

[0029] After the standby step S4, as shown in FIG. 9, while maintaining the puncture state of the arterial puncture needle a and the venous puncture needle b with respect to the patient, the blood pump 4 is driven forward, and at the same time, dialysis fluid is introduced into the dialyzer 3 through the dialysis fluid introduction line L1 and the drained fluid is discharged through the drained fluid discharge line L2. Thereby, a blood purification treatment step S5 is executed in which the patient's blood is extracorporeally circulated in the blood circuit and purified by the dialyzer 3.

[0030] However, in the transfer step according to the present embodiment, as shown in FIG. 6, heparin H is transferred only to the tip of the venous blood circuit 2, but as shown in FIG. 11, it may transfer heparin H only to the tip of the arterial blood circuit 1, or as shown in FIG. 12, it may transfer heparin H to both the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2.

[0031] Next, the configuration around the control unit 9 according to the present embodiment and the control by the peripheral configuration will be described based on the block diagram of FIG. 10. As shown in FIG. 10, the control unit 9 according to the present embodiment includes a microcomputer 9a, and the microcomputer 9a is electrically connected to the touch panel 10a of the input unit 10 so as to be able to receive an input signal from the touch panel 10a. Further, the microcomputer 9a is connected to a drive unit 11 having an actuator P1 of the blood pump 4, an actuator P2 of the infusion pump 5, a drive coil J1 of the clamping means K1 (first electromagnetic valve), a drive coil J2 of the clamping means K2 (second electromagnetic valve), and a drive coil J3 of the clamping means K3 (third electromagnetic valve).

[0032] In the present embodiment, in a state where the blood circuit is filled with the priming liquid, a drive signal is supplied to the actuator P2 of the infusion pump 5 to drive the infusion pump 5. In a state where the anticoagulant is injected into the blood circuit by the drive of the infusion pump 5, a first drive signal is supplied to the actuator P1 of the blood pump 4 to first drive the blood pump 4. By the first drive of the blood pump 4, the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2. In a state where the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, a second drive signal is supplied to the actuator P1 of the blood pump 4 to second drive the blood pump 4, and the processing for this is configured to be executed.

[0033] Furthermore, in the present embodiment, it includes a first electromagnetic valve (clamping means K1) for opening and closing the end of the arterial blood circuit 1, a second electromagnetic valve (clamping means K2) for opening and closing the end of the venous blood circuit 2, and a third electromagnetic valve (clamping means K3) for opening and closing the supply line for supplying the dialysate. The microcomputer 9a of the control unit 9 is configured to execute processing for setting the first electromagnetic valve and the second electromagnetic valve in an open state and the third electromagnetic valve in a closed state before the anticoagulant is injected, and setting the first electromagnetic valve and the second electromagnetic valve in a closed state and the third electromagnetic valve in a closed state after the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2.

[0034] Next, the configuration around the control unit 9 according to the present embodiment and the control by the peripheral configuration will be described based on the timing chart of FIG. 13. This timing chart assumes a case where heparin H is transferred only to the tip of the venous side blood circuit 2 (see FIG. 6). In the priming step (600 (s)), the actuator P1 for the blood pump is turned on (with a driving signal for forward rotation), and the blood pump 4 is driven in forward rotation. The actuator P2 for the injection pump is turned off (without a driving signal), and the injection pump 5 is stopped. At the same time, the drive coils J1, J2, and J3 of the clamp solenoid valves are turned on (with driving signals) to open the flow path. In the present embodiment, the clamp solenoid valves (J1 to J3) are in a closed state in the initial state (when there is no driving signal), but they may be in an open state in the initial state.

[0035] In the injection step (60 (s)), the actuator P1 for the blood pump is turned off (without a driving signal), and the blood pump 4 is stopped. The actuator P2 for the injection pump is turned on (with a driving signal), and the injection pump 5 is driven. At the same time, the drive coils J1 and J2 of the clamp solenoid valves are turned on (with driving signals) to open the flow path, and the drive coil J3 of the clamp solenoid valve is turned off (without a driving signal) to close the flow path.

[0036] In the transfer step (60 (s)), the actuator P1 for the blood pump is turned on (with a driving signal for reverse rotation), and the blood pump 4 is driven in reverse rotation. The actuator P2 for the injection pump is turned off (without a driving signal), and the injection pump 5 is stopped. At the same time, the drive coils J1 and J2 of the clamp solenoid valves are turned on (with driving signals) to open the flow path, and the drive coil J3 of the clamp solenoid valve is turned off (without a driving signal) to close the flow path.

[0037] During the subsequent puncture operation, the actuator P1 for the blood pump is turned off (no drive signal), and the blood pump 4 is stopped. The actuator P2 for the infusion pump is turned off (no drive signal), and the infusion pump 5 is stopped. At the same time, the drive coils J1, J2, and J3 of the clamp solenoid valve are turned off (no drive signal), closing the flow path.

[0038] In the venous administration step (60 (s)), the actuator P1 for the blood pump is turned on (with a drive signal for forward rotation), and the blood pump 4 is driven in forward rotation. The actuator P2 for the infusion pump is turned off (no drive signal), and the infusion pump 5 is stopped. At the same time, the drive coils J2 and J3 of the clamp solenoid valve are turned on (with a drive signal), opening the flow path, and the drive coil J1 of the clamp solenoid valve is turned off (no drive signal), closing the flow path.

[0039] In the standby step (600 (s)), the actuator P1 for the blood pump is turned off (no drive signal), and the blood pump 4 is stopped. The actuator P2 for the infusion pump is turned off (no drive signal), and the infusion pump 5 is stopped. At the same time, the drive coils J1, J2, and J3 of the clamp solenoid valve are turned off (no drive signal), closing the flow path.

[0040] At the start of the blood purification treatment step (4 (h)), the actuator P1 for the blood pump is turned on (with a drive signal for forward rotation), and the blood pump 4 is driven in forward rotation. The actuator P2 for the infusion pump is turned off (no drive signal), and the infusion pump 5 is stopped. At the same time, the drive coils J1 and J2 of the clamp solenoid valve are turned on (with a drive signal), opening the flow path, and the drive coil J3 of the clamp solenoid valve is turned off (no drive signal), closing the flow path.

[0041] Next, the configuration around the control unit 9 according to the present embodiment and the control by the peripheral configuration will be described based on the timing chart of FIG. 14. This timing chart assumes a case where heparin H is transferred only to the tip of the arterial blood circuit 1 (see FIG. 11). The priming process, injection process, transfer process, puncture process, standby process, and treatment process are the same as those in the case where heparin H is transferred only to the tip of the venous blood circuit 2.

[0042] In the arterial administration process (1(s), 2(s)), the actuator P1 for the blood pump is turned on (with a driving signal for forward rotation) to drive the blood pump 4 in forward rotation, the actuator P2 for the injection pump is turned off (without a driving signal) to stop the injection pump 5, the drive coil J3 of the clamp solenoid valve is turned on (with a driving signal) to open the flow path, the drive coils J1 and J2 of the clamp solenoid valve are turned off (without a driving signal) to close the flow path, and the actuator P1 for the blood pump is turned on (with a driving signal for reverse rotation) to drive the blood pump 4 in reverse rotation, the actuator P2 for the injection pump is turned off (without a driving signal) to stop the injection pump 5, the drive coil J1 of the clamp solenoid valve is turned on (with a driving signal) to open the flow path, and the drive coils J2 and J3 of the clamp solenoid valve are turned off (without a driving signal) to close the flow path. These states are repeated the required number of times.

[0043] Next, the configuration around the control unit 9 according to the present embodiment and the control by the peripheral configuration will be described based on the timing chart of FIG. 15. This timing chart assumes a case where heparin H is transferred to the tips of both the arterial blood circuit 1 and the venous blood circuit 2 (see FIG. 12). The priming process, injection process, transfer process, puncture process, standby process, venous administration process, and treatment process are the same as those in the case where heparin H is transferred only to the tip of the venous blood circuit 2, and the arterial administration process is the same as that in the case where heparin H is transferred only to the tip of the arterial blood circuit 1.

[0044] According to the present embodiment, after the priming step S1, an injection step of driving the injection pump 5 to inject an anticoagulant into the blood circuit, a transfer step of first driving the blood pump 4 to transfer the anticoagulant injected in the injection step to the tips of the arterial side blood circuit 1 and the venous side blood circuit 2, and a second driving of the blood pump 4 with the tips of the arterial side blood circuit 1 and the venous side blood circuit 2 punctured into the patient to administer the anticoagulant transferred in the transfer step to the patient are sequentially executed by the control unit 9. Therefore, when administering an anticoagulant to a patient before blood purification treatment, the amount of the priming solution (physiological saline) administered together with the anticoagulant can be reduced.

[0045] In addition, by reducing the administration amount of the priming solution, it is possible to suppress the reduction of the heart load (prevention of blood pressure increase) due to fluid overload. Furthermore, by enhancing the blood coagulation inhibition effect, the administration amount of heparin can be reduced, and it is possible to reduce the cost of the anticoagulant (heparin) and the side effects of the anticoagulant (heparin). Conventionally, medical staff measured the waiting time and waited until the start of treatment, but the device can automatically perform it, thus saving the time and effort of medical staff.

[0046] Also, the control unit 9 according to the present embodiment executes a waiting step of waiting until a predetermined time elapses after the administration step, so that the heparin H administered into the patient's body can be activated to sufficiently enhance the blood coagulation inhibition effect, and when the patient's blood is extracorporeally circulated in the subsequent blood purification treatment step S5, blood coagulation can be suppressed.

[0047] Furthermore, in the priming step S1 according to the present embodiment, by connecting the tips of the arterial side blood circuit 1 and the venous side blood circuit 2 to each other to form a closed circuit and filling it with a priming solution (physiological saline), and maintaining the closed circuit in the injection step and the transfer step, the injection step and the transfer step can be executed by diverting the closed circuit formed in the priming step S1.

[0048] Furthermore, in the transfer step according to the present embodiment, since the blood pump 4 can be reversely driven to transfer heparin H to the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2, it is possible to avoid the heparin H injected in the injection step from passing through the dialyzer 3, and the heparin H can be surely transferred to the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2.

[0049] In addition, in the administration step S3 according to the present embodiment, the blood pump 4 can be driven forward to administer the heparin H at the tip of the venous blood circuit 2 to the patient, and the blood pump 4 can be driven reversely to administer the heparin H at the tip of the arterial blood circuit 1 to the patient. Therefore, the heparin H at the tip of the venous blood circuit 2 and the heparin H at the tip of the arterial blood circuit 1 can be surely administered to the patient.

[0050] As described above, the present embodiment has been described. However, the present invention is not limited to these. For example, as shown in FIG. 16, a supply line Lb is connected between the dialysate introduction line L1 and a predetermined portion of the arterial blood circuit 1 (the position between the connector 1a and the portion where the blood pump 4 is disposed in the figure), and a clamp means K3 composed of an electromagnetic valve is connected in the middle of the supply line Lb. It may be applied to this. In this case, the priming liquid filled in the priming step is the dialysate supplied from the supply line Lb, and can be supplied to the blood circuit by keeping the clamp means K3 open.

[0051] Also, in the administration step S3, when heparin H is transferred to the tip of the arterial blood circuit 1, the blood pump 4 is driven forward while keeping the clamp means K2 closed to fill and accumulate the priming liquid (physiological saline or dialysate) in the air trap chamber 6, and then the blood pump 4 is driven reversely. Thus, the accumulated priming liquid may be caused to flow toward the arterial blood circuit 1 to administer the heparin H at the tip of the arterial blood circuit 1 into the patient's body.

[0052] In this case, as shown in FIGS. 14 and 15, the control unit 9 drives the blood pump 4 in the forward rotation while closing the flow path by the clamping means K2, and accumulates pressure between the installation position of the blood pump 4 and the installation position of the clamping means K2 in an accumulation step (1(s)), and drives the blood pump 4 in the reverse rotation while maintaining the closing of the flow path by the clamping means K2, and can have a step (2(s)) of administering heparin H from the tip of the arterial blood circuit 1. The accumulation step is a step of increasing and accumulating the pressure of the air trap chamber 6 by driving the blood pump 4 in the forward rotation with the clamping means K1 and the clamping means K2 in the closed state and the clamping means K3 in the open state under the control of the control unit 9. By this accumulation step, a predetermined amount of priming liquid used when administering heparin H from the tip of the arterial blood circuit 1 can be stored and secured. It is preferable to provide a pressure sensor in the air trap chamber 6 to detect and monitor the pressure during accumulation.

[0053] Furthermore, in the transfer step, after transferring heparin H only to the tip of the arterial blood circuit 1 or only to the tip of the venous blood circuit 2, either the forward rotation or the reverse rotation of the blood pump 4 is performed in the administration step S3, so that heparin H at the tip of the arterial blood circuit 1 or heparin H at the tip of the venous blood circuit 2 may be administered to the patient. In this case, the execution time of the administration step S3 can be shortened.

[0054] Furthermore, when transferring heparin H to both the arterial blood circuit 1 and the venous blood circuit 2, the administration step S3 according to the present embodiment is configured to administer heparin H to the patient from the tip of the venous blood circuit 2 and then administer heparin H to the patient from the tip of the arterial blood circuit 1, but it may be configured to administer heparin H to the patient from the tip of the arterial blood circuit 1 and then administer heparin H to the patient from the tip of the venous blood circuit 2, or to alternately administer heparin H to the patient from both the tip of the arterial blood circuit 1 and the tip of the venous blood circuit 2.

[0055] A first embodiment of the present invention is a blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial blood circuit 1 and a venous blood circuit 2 and a blood purifier, and purifies the blood. The blood purification device includes a blood pump 4 that causes blood in the blood circuit to flow and extracorporeally circulate, an injection pump 5 that injects an anticoagulant into a predetermined site, and a control unit 9 that controls the blood pump 4 and the injection pump 5. In a state where the blood circuit is filled with a priming liquid, the control unit 9 supplies a drive signal to the injection pump 5 to drive the injection pump 5. In a state where the anticoagulant is injected into the blood circuit by driving the injection pump 5, the control unit 9 supplies a first drive signal to the blood pump 4 to first drive the blood pump 4. By the first drive of the blood pump 4, the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2. In a state where the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, the control unit 9 supplies a second drive signal to the blood pump 4 to second drive the blood pump 4. This configuration enables the reduction of the amount of priming liquid (physiological saline) administered together with the anticoagulant when administering the anticoagulant to the patient before blood purification treatment.

[0056] A second embodiment of the present invention is, in the first embodiment, a first electromagnetic valve (clamping means K1) that opens and closes the end of the arterial blood circuit 1, a second electromagnetic valve (clamping means K2) that opens and closes the end of the venous blood circuit 2, and a third electromagnetic valve (clamping means K3) that opens and closes a supply line for supplying dialysate. The control unit 9 opens the first electromagnetic valve and the second electromagnetic valve Transfer before the anticoagulant is administered, and closes the first electromagnetic valve and the second electromagnetic valve after the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2, and closes the third electromagnetic valve. This configuration enables the control of the electromagnetic valves to administer the anticoagulant when administering the anticoagulant to the patient before blood purification treatment. state

[0057] A third embodiment of the present invention is a blood purification device that, in the second embodiment, transfers an anticoagulant to the tip of the venous blood circuit 2 by the first drive of the blood pump 4, and when the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, the second electromagnetic valve (clamping means K2) and the third electromagnetic valve (clamping means K3) are opened, and the first electromagnetic valve (clamping means K1) is closed. This has the effect of being able to administer an anticoagulant from the tip of the venous blood circuit 2 by controlling the electromagnetic valve.

[0058] A fourth embodiment of the present invention is a blood purification device that, in the second embodiment, transfers an anticoagulant to the tip of the arterial blood circuit 1 by the first drive of the blood pump 4, and when the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, the first electromagnetic valve (clamping means K1) and the third electromagnetic valve (clamping means K3) are appropriately opened while the second electromagnetic valve (clamping means K2) is closed. This has the effect of being able to administer an anticoagulant from the tip of the arterial blood circuit 1 by controlling the electromagnetic valve.

[0059] A fifth embodiment of the present invention is a blood purification device that, in the fourth embodiment, includes a pressure accumulation step of driving the blood pump 4 forward to accumulate pressure while closing the first electromagnetic valve (clamping means K1) and the second electromagnetic valve (clamping means K2) and opening the third electromagnetic valve (clamping means K3), and a step of rotating the blood pump 4 in reverse while opening the first electromagnetic valve (clamping means K1) and closing the second electromagnetic valve (clamping means K2) and the third electromagnetic valve (clamping means K3). This enables pressure accumulation and administration of an anticoagulant.

[0060] A sixth embodiment of the present invention is a blood purification device that, in the first embodiment, is configured such that the control unit 9 executes a process for waiting until a predetermined time elapses after the blood pump 4 performs the first drive or the second drive, so that it is possible to wait for a predetermined time after administering the anticoagulant.

[0061] The seventh embodiment of the present invention is a blood purification device that, in the first embodiment, connects the tip of the arterial blood circuit and the tip of the venous blood circuit to form a closed circuit, fills it with a priming solution, and drives the infusion pump to inject an anticoagulant into the blood circuit. In this state, the control unit first drives the blood pump. Thereby, it is possible to maintain the state of the closed circuit formed in the priming process and perform the first drive.

[0062] An eighth embodiment of the present invention is a blood purification device including a blood pump 4 that circulates blood in a blood circuit for extracorporeal circulation and a control unit 9 that controls an infusion pump 5 for injecting an anticoagulant at a predetermined site. A processing method executed by the control unit 9, in a state where the blood circuit is filled with a priming solution, a step of supplying a drive signal to the infusion pump 5 to drive the infusion pump 5, and in a state where an anticoagulant is injected into the blood circuit by driving the infusion pump 5, a step of supplying a first drive signal to the blood pump 4 to first drive the blood pump 4, and by the first drive of the blood pump 4, the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2, and when the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, supplying a second drive signal to the blood pump 4 and second driving the blood pump 4. This has the effect of reducing the amount of the priming solution (physiological saline) administered together with the anticoagulant when administering the anticoagulant to the patient before blood purification treatment.

[0063] The ninth embodiment of the present invention is a blood purification device including a blood pump 4 for circulating blood in a blood circuit for extracorporeal circulation and an injection pump 5 for injecting an anticoagulant into a predetermined site, wherein the control unit 9 is configured to supply a drive signal to the injection pump 5 to drive the injection pump 5 in a state where the blood circuit is filled with a priming liquid, and in a state where the anticoagulant is injected into the blood circuit by driving the injection pump 5, supply a first drive signal to the blood pump 4 to drive the blood pump 4 for the first time, and by the first drive of the blood pump 4, the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2, and in a state where the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, supply a second drive signal to the blood pump 4. This has the effect of reducing the amount of priming liquid (physiological saline) administered together with the anticoagulant when administering the anticoagulant to the patient before blood purification treatment.

[0064] Alternatively, there may be provided a storage medium storing a program that causes the control unit 9 in a blood purification device including a blood pump 4 for circulating blood in a blood circuit for extracorporeal circulation and an injection pump 5 for injecting an anticoagulant into a predetermined site to supply a drive signal to the injection pump 5 to drive the injection pump 5 in a state where the blood circuit is filled with a priming liquid, and in a state where the anticoagulant is injected into the blood circuit by driving the injection pump 5, supply a first drive signal to the blood pump 4 to drive the blood pump 4 for the first time, and by the first drive of the blood pump 4, the anticoagulant is transferred to the tip of the arterial blood circuit 1 or the tip of the venous blood circuit 2, and in a state where the tips of the arterial blood circuit 1 and the venous blood circuit 2 are punctured into the patient, supply a second drive signal to the blood pump 4.

Industrial Applicability

[0065] A blood purification device equivalent to the gist of the present invention can be applied to those having different external shapes or those with additional other functions.

Explanation of Reference Numerals

[0066] 1 Arterial blood circuit 1a Connector 2 Venous blood circuit 2a Connector 3 Dialyzer (blood purifier) 4 Blood pump 5 Infusion pump 6 Air trap chamber 7 Containment vessel 8 Dialysis device main body 9 Control unit M Syringe H Heparin (anticoagulant) K1~K3 Clamping means

Claims

1. A blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial blood circuit and a venous blood circuit and a blood purifier to purify the blood, a blood pump that causes the blood in the blood circuit to flow and extracorporeally circulate, an injection pump that injects an anticoagulant into a predetermined site, an anticoagulant injection line to which the injection pump is connected, a control unit that controls the blood pump and the injection pump, and comprising: In a state where the blood circuit is filled with a priming solution, a drive signal is supplied to the injection pump to drive the injection pump, and in a state where the anticoagulant is injected into the blood circuit by the drive of the injection pump, a first drive signal is supplied to the blood pump to first drive the blood pump, and by the first drive of the blood pump, the priming solution in an amount corresponding to the volume from the connection portion with the anticoagulant injection line in the blood circuit to the tip of the arterial blood circuit and / or the tip of the venous blood circuit is caused to flow, and the anticoagulant is transferred to the tip of the arterial blood circuit and / or the tip of the venous blood circuit, and in a state where the tips of the arterial blood circuit and the venous blood circuit are punctured into the patient, a second drive signal is supplied to the blood pump. A blood purification device configured as such.

2. A blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial blood circuit and a venous blood circuit and a blood purifier to purify the blood, a blood pump that causes the blood in the blood circuit to flow and extracorporeally circulate, an injection pump that injects an anticoagulant into a predetermined site, an anticoagulant injection line to which the injection pump is connected, a control unit that controls the blood pump and the injection pump, and comprising: In a state where the blood circuit is filled with a priming liquid, a drive signal is supplied to the infusion pump to drive the infusion pump. In a state where the anticoagulant is injected into the blood circuit by driving the infusion pump, a first drive signal is supplied to the blood pump to drive the blood pump for the first time. By the first drive of the blood pump, a volume of the priming liquid from the connection portion with the anticoagulant injection line in the blood circuit to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit is caused to flow, and the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit. In a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, it is configured to supply a second drive signal to the blood pump, and a first electromagnetic valve that opens and closes an end of the arterial side blood circuit, a second electromagnetic valve that opens and closes an end of the venous side blood circuit, a third electromagnetic valve that opens and closes a supply line for supplying dialysate, and includes a blood purification device configured to execute a process for opening the first electromagnetic valve and the second electromagnetic valve before the anticoagulant is transferred, closing the first electromagnetic valve and the second electromagnetic valve after the anticoagulant is transferred to the tip of the arterial side blood circuit or the tip of the venous side blood circuit, and closing the third electromagnetic valve.

3. A blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial side blood circuit and a venous side blood circuit and a blood purifier to purify the blood, a blood pump that causes the blood in the blood circuit to flow for extracorporeal circulation, an infusion pump that injects an anticoagulant at a predetermined site, a control unit that controls the blood pump and the infusion pump, and includes In a state where the blood circuit is filled with a priming liquid, a drive signal is supplied to the infusion pump to drive the infusion pump, and in a state where the anticoagulant is injected into the blood circuit by driving the infusion pump, a first drive signal is supplied to the blood pump to drive the blood pump for the first time. By the first driving of the blood pump, the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit. In a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, the control unit is configured to supply a second drive signal to the blood pump, and a first electromagnetic valve that opens and closes an end of the arterial side blood circuit; a second electromagnetic valve that opens and closes an end of the venous side blood circuit; a third electromagnetic valve that opens and closes a supply line for supplying dialysate; and is configured to execute processing for, before the anticoagulant is transferred, putting the first electromagnetic valve and the second electromagnetic valve in an open state, after the anticoagulant is transferred to the tip of the arterial side blood circuit or the tip of the venous side blood circuit, putting the first electromagnetic valve and the second electromagnetic valve in a closed state, and putting the third electromagnetic valve in a closed state. A blood purification device that, in a state where the anticoagulant is transferred to the tip of the venous side blood circuit by the first driving of the blood pump and the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, puts the second electromagnetic valve and the third electromagnetic valve in an open state and puts the first electromagnetic valve in a closed state.

4. A blood purification device that extracorporeally circulates a patient's blood through a blood circuit having an arterial side blood circuit and a venous side blood circuit and a blood purifier to purify the blood, including a blood pump that causes the blood in the blood circuit to flow and extracorporeally circulate, an infusion pump that injects an anticoagulant at a predetermined site, and a control unit that controls the blood pump and the infusion pump, wherein the control unit is provided with In a state where the blood circuit is filled with a priming solution, a drive signal is supplied to the infusion pump to drive the infusion pump. In a state where the anticoagulant is injected into the blood circuit by driving the infusion pump, a first drive signal is supplied to the blood pump to drive the blood pump for the first time. By the first drive of the blood pump, the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit. In a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, it is configured to supply a second drive signal to the blood pump, and a first electromagnetic valve for opening and closing an end of the arterial side blood circuit; a second electromagnetic valve for opening and closing an end of the venous side blood circuit; a third electromagnetic valve for opening and closing a supply line for supplying dialysate; and includes, and the control unit Before the anticoagulant is transferred, the first electromagnetic valve and the second electromagnetic valve are opened. After the anticoagulant is transferred to the tip of the arterial side blood circuit or the tip of the venous side blood circuit, the first electromagnetic valve and the second electromagnetic valve are closed, and the third electromagnetic valve is closed. It is configured to execute a process for this. A blood purification device that, when the anticoagulant is transferred to the tip of the arterial side blood circuit by the first drive of the blood pump and the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, appropriately opens the first electromagnetic valve and the third electromagnetic valve while keeping the second electromagnetic valve closed.

5. A pressure accumulation step of driving the blood pump forward to accumulate pressure while keeping the first electromagnetic valve and the second electromagnetic valve closed and the third electromagnetic valve open, and a step of rotating the blood pump reversely while keeping the first electromagnetic valve open and the second electromagnetic valve and the third electromagnetic valve closed are repeatedly performed. The blood purification device according to claim 4.

6. The blood purification device according to claim 1, wherein the control unit is configured to execute a process of waiting until a predetermined time elapses after the blood pump is driven for the second time.

7. The blood purification device according to claim 1, wherein the tip of the arterial side blood circuit and the tip of the venous side blood circuit are connected to form a closed circuit, filled with a priming liquid, and in a state where the anticoagulant is injected into the blood circuit by the driving of the injection pump, the control unit drives the blood pump for the first time.

8. In a blood purification device including a blood pump that circulates blood in a blood circuit outside the body and a control unit that controls an injection pump that injects an anticoagulant at a predetermined site, a processing method executed by the control unit, a step of the control unit supplying a drive signal to the injection pump to drive the injection pump in a state where the blood circuit is filled with a priming liquid; a step of the control unit supplying a first drive signal to the blood pump to drive the blood pump for the first time in a state where the anticoagulant is injected into the blood circuit by the driving of the injection pump; a step of the control unit supplying a second drive signal to the blood pump to drive the blood pump for the second time in a state where the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit by the first drive of the blood pump, and the tips of the arterial side blood circuit and the venous side blood circuit are punctured into a patient; A processing method including.

9. In a blood purification device including a blood pump that circulates blood in a blood circuit outside the body and a control unit that controls an injection pump that injects an anticoagulant at a predetermined site, a processing method executed by the control unit, a step of the control unit supplying a drive signal to the injection pump to drive the injection pump in a state where the blood circuit is filled with a priming liquid; In a state where the anticoagulant is injected into the blood circuit by the drive of the injection pump, a step of the control unit supplying a first drive signal to the blood pump to drive the blood pump for the first time; By the first drive of the blood pump, the anticoagulant is transferred to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit. In a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into the patient, the control unit supplies a second drive signal to the blood pump and drives the blood pump for the second time; including, and the blood purification device a first electromagnetic valve for opening and closing an end of the arterial side blood circuit; a second electromagnetic valve for opening and closing an end of the venous side blood circuit; a third electromagnetic valve for opening and closing a supply line for supplying dialysate; equipped with, and the control unit Before the anticoagulant is transferred, the first electromagnetic valve and the second electromagnetic valve are opened. After the anticoagulant is transferred to the tip of the arterial side blood circuit or the tip of the venous side blood circuit, the first electromagnetic valve and the second electromagnetic valve are closed, and the third electromagnetic valve is closed. A processing method for executing the processing for this purpose.

10. In a blood purification device comprising a blood pump for circulating blood in a blood circuit for extracorporeal circulation, a control unit for controlling an infusion pump for injecting an anticoagulant into a predetermined site, and an anticoagulant infusion line to which the infusion pump is connected, the control unit is configured to supply a drive signal to the infusion pump to drive the infusion pump in a state where the blood circuit is filled with a priming solution, and in a state where the anticoagulant is injected into the blood circuit by driving the infusion pump, supply a first drive signal to the blood pump to perform a first drive of the blood pump, and by the first drive of the blood pump, flow a volume of the priming solution from a connection portion with the anticoagulant infusion line in the blood circuit to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit, thereby transferring the anticoagulant to the tip of the arterial side blood circuit and / or the tip of the venous side blood circuit, and in a state where the tips of the arterial side blood circuit and the venous side blood circuit are punctured into a patient, supply a second drive signal to the blood pump. A program that functions as described above.

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