Catheter device for optomechanical treatment

Abstract

The photodynamic therapy catheter device includes a catheter movable to a lesion site in tissue, a stent that is movably mounted at the end of the catheter to enable a change in length and is coated with a photoresponsive agent, and an optical fiber that can be moved in and out of the catheter to be located in the center of the stent, and the optical fiber can irradiate a laser toward the photoresponsive agent to activate the photoresponsive agent after the stent is pulled out of the catheter and expanded.

Description

[Technical field]

[0001] The present invention relates to a catheter device for photodynamic therapy. [Background technology]

[0002] Generally, surgical procedures, stent or drug-releasing stent procedures, etc. are used in clinical practice to treat malignant stenotic diseases and tumors in luminal organs.

[0003] However, in the case of conventional surgical procedures, the recovery period for patients is very long and there is a high risk of complications. In the case of stents and drug-releasing stents, although there is an advantage that the procedure is minimally invasive and the recovery period for patients is very short, there is a risk of the need to remove the stent, along with the problem of restenosis.

[0004] Meanwhile, research into grafting photodynamic therapy to target cancer has been actively conducted in recent years, but there are limitations, such as the extremely long research period for photoresponsive agents that enable targeted therapy, and the many difficulties involved in their development and approval. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Korean Patent Application Publication No. 10-1650515 Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide a photodynamic therapy catheter device capable of activating a photoresponsive agent coated on a stent to proceed with photodynamic therapy on a lesion site. [Means for solving the problem]

[0007] According to one aspect of the present invention, there can be provided a catheter movable to a diseased site of an organ; a stent installed to be able to enter and exit from an end of the catheter to enable a change in length and coated with a photosensitizer; and an optical fiber installed to be able to enter and exit from the catheter so as to be positioned at the center of the stent, the optical fiber irradiating a laser toward the photosensitizer for activation of the photosensitizer after the stent is pulled out from the catheter and expanded, which is a catheter device for photodynamic therapy.

[0008] Furthermore, the catheter device for photodynamic therapy can further include a guide wire installed to be able to enter and exit from the catheter and guiding the catheter so that the catheter moves to the diseased site.

[0009] Furthermore, the catheter includes a support tube movable along the guide wire; an adjustment tube providing a tube passage inside which the guide wire or the optical fiber is movable and supported by the support tube so as to dispose at least a part of the stent outside; a moving tube configured to accommodate at least a part of the stent inside and movable along the support tube so that an extended length of the stent protruding outside the catheter is adjusted; and a guide tip connected to an end of the adjustment tube and communicating with the tube passage so that the guide wire or the optical fiber is movable.

[0010] Furthermore, the extended length of the stent can be adjusted in proportion to a moving distance of the moving tube.

[0011] Also, when the stent is pressed by the moving tube, it is positioned in a space between the adjustment tube and the moving tube, maintains a state of being crimped while wrapping the adjustment tube, and can be expanded and restored to its original form when the pressing of the moving tube is released.

[0012] Furthermore, a rear end of the stent can be fixed to the catheter, and a front end of the stent can be fixed to the guide tip or provided in a form of a free end.

[0013] In addition, the stent can be provided in a cylindrical mesh form that crimps and wraps the adjustment tube by pressing the movement tube in the space between the adjustment tube and the movement tube of the catheter.

[0014] Furthermore, the catheter further includes a pusher connected to the rear end of the movement tube. When the pressing of the movement tube is released as the movement tube moves rearward during the pulling operation of the pusher, the stent can be expanded from the adjustment tube of the catheter so as to adhere to the lesion site, and can be recovered into the adjustment tube of the catheter by the pressing of the movement tube in response to the forward movement of the movement tube during the pushing operation of the pusher.

[0015] Furthermore, the photosensitizer can include one or more of Chlorin e6, Hematoporphyrin, Methylene blue, and Toluidine blue.

Advantages of the Invention

[0016] The embodiments of the present invention use a stent widely used for non-vascular stenosis diseases for lumen dilation, coat the stent with a photosensitizer, and constitute a catheter device that delivers the photosensitizer to a luminal organ (such as the esophagus, duodenum, biliary tract, pancreas, large intestine, small intestine, etc.) having a malignant stenosis disease as a target, thereby having the advantage of being able to kill cells such as cancer and stenosis diseases through photodynamic therapy.

[0017] Furthermore, the embodiments of the present invention have the advantage of being able to contribute to the treatment of malignant stenosis diseases by irradiating a laser on the photosensitizer coated on the catheter device to activate the photosensitizer.

[0018] In addition, the embodiments of the present invention have the advantages that the catheter device can be recovered after photodynamic therapy, and the range capable of photodynamic therapy can be deformed according to the length of the lesion.

Brief Description of the Drawings

[0019]

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Fig. 6

Fig. 7

Fig. 8

Fig. 9

Fig. 10

Modes for Carrying Out the Invention

[0020] Hereinafter, specific embodiments for realizing the technical idea of the present invention will be described in detail based on the accompanying drawings.

[0021] In addition, in the description of the present invention, when it is determined that a specific description of a related known configuration or function may obscure the gist of the present invention, the detailed description thereof is omitted.

[0022] Also, when a certain component is referred to as being "connected", "supported", "connected to", "supplied to", "transmitted to", "contacted with" another component, it should be understood that it can be directly connected, supported, connected to, supplied to, transmitted to, contacted with the other component, but other components may also exist therebetween.

[0023] The terms used in this specification are merely used to describe specific embodiments and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly has a different meaning.

[0024] Note that in this specification, expressions such as upper side, lower side, side surface, etc. are described with reference to the illustrations in the drawings, and it is clarified in advance that the expressions will be different if the orientation of the corresponding object changes. For the same reason, in the attached drawings, some components are shown exaggeratedly, omitted, or schematically, and the sizes of the respective components do not fully reflect the actual sizes.

[0025] Furthermore, terms including ordinal numbers such as first, second, etc. can be used to describe various components, but the corresponding components are not limited by such terms. These terms are only used for the purpose of distinguishing one component from another.

[0026] The meaning of "including" used in this specification does not specify a specific characteristic, region, constant, step, operation, element and / or component, and does not exclude the existence or addition of other specific characteristics, regions, constants, steps, operations, elements, components and / or groups.

[0027] Hereinafter, with reference to FIGS. 1 to 10, the specific configuration of a catheter device for photodynamic therapy according to an embodiment of the present invention will be described.

[0028] Figure 1 is a configuration diagram showing a catheter device for photodynamic therapy according to an embodiment of the present invention, Figure 2 is an enlarged view showing an enlarged portion "A" of Figure 1, and Figure 3 is a configuration diagram showing a catheter device for photodynamic therapy according to a modified example of the present invention.

[0029] As shown in FIGS. 1 to 2, the catheter device 10 for photodynamic therapy according to an embodiment of the present invention can include a guide wire 100, a catheter 200, and a stent 300.

[0030] Specifically, the guide wire 100 can be provided in the form of a wire for guiding the catheter 200 to a lesion site L that has occurred in the tissue of a luminal organ (such as the esophagus, duodenum, biliary tract, pancreas, large intestine, small intestine, etc.) having a malignant stricture disease. The guide wire 100 can be inserted into and attached to the catheter 200 so as to be able to move through the catheter 200. As an example, the guide wire 100 may be a guiding wire that can move to the lesion site L.

[0031] The catheter 200 can be guided by the guide wire 100 and moved to the lesion site L of the tissue. In a state where the catheter 200 is disposed at the lesion site L of the tissue, the guide wire 100 can be separated from the catheter 200, the stent 300 can be expanded toward the lesion site L of the tissue, and the optical fiber 400 can be inserted into the catheter 200 and disposed so as to be close to the lesion site L of the tissue.

[0032] Such a catheter 200 can include a support tube 210, an adjustment tube 220, a sheath hub 230, a moving tube 240, and a pusher 250. The support tube 210 can be provided in the form of a hollow tube. The adjustment tube 220 can be provided inside the support tube 210. A sheath hub 230 can be coupled to the rear end of the support tube 210.

[0033] The adjustment tube 220 can be provided in the form of a hollow tube. The adjustment tube 220 can be installed through the support tube 210. Inside the adjustment tube 220, a tube passage can be provided through which the guide wire 100 or the optical fiber 400 can be inserted and moved. A stent 300 can be attached to the peripheral edge of the tip side of the adjustment tube 220. And a conical guide tip 260 can be coupled to the tip of the adjustment tube 220. A sheath hub 230 can be coupled to the rear end of the adjustment tube 220.

[0034] The sheath hub 230 can be coupled to the rear end of the support tube 210. The sheath hub 230 can be provided in the form of a hollow tube through which the moving tube 240 passes.

[0035] The moving tube 240 can be disposed between the support tube 210 and the adjustment tube 220 so as to be movable in the longitudinal direction. For example, the inner diameter of the moving tube 240 may be larger than the outer diameter of the adjustment tube 220, and the outer diameter of the moving tube 240 may be smaller than the inner diameter of the support tube 210. The tip portion of the moving tube 240 can be provided in the form of a tube that selectively wraps the stent 300.

[0036] The rear end portion of the moving tube 240 can be connected to the pusher 250. When the pusher 250 performs a pull or push operation, the moving tube 240 can move backward or forward along the support tube 210. The moving tube 240 can be made of a transparent or translucent material. When the moving tube 240 moves backward (the direction in which the pusher pulls) along the support tube 210, the stent 300 can be released from the moving tube 240 and expand.

[0037] The pusher 250 can include a pusher cap 251 coupled to the rear end of the sheath hub 230 and an adjustment cap 252 connected to the rear end of the moving tube 240 to move the moving tube 240. When the adjustment cap 252 moves in a direction away from the pusher cap 251 during the pull operation of the pusher 250, the moving tube 240 can move rearward along the support tube 210. And when the adjustment cap 252 moves in a direction approaching the pusher cap 251 during the push operation of the pusher 250, the moving tube 240 can move forward along the support tube 210.

[0038] The stent 300 can be provided in a cylindrical or bag-shaped mesh form. The stent 300 can be expanded length-adjustably from the end of the catheter 200 or retrieved to the end of the catheter 200.

[0039] For example, when the stent 300 is pressed by the moving tube 240 due to the forward movement of the moving tube 240, the stent 300 is located in the space between the adjustment tube 220 and the moving tube 240 of the catheter 200, so it can maintain a state of being crimped while wrapping the adjustment tube 220. And when the pressing of the moving tube 240 on the stent 300 is released by the rearward movement of the moving tube 240, the stent 300 can be expanded while being restored to its original mesh form and expanded.

[0040] At this time, the rear end portion (distal portion) of the stent 300 can be fixed to the adjustment tube 220 of the catheter 200, and the front end portion (proximal portion) of the stent 300 can be fixed to the guide tip 260 of the catheter 200. In this way, when the rear end portion and the front end portion of the stent 300 are fixed to the catheter 200, the stent 300 is concentratedly arranged at the central part of the tissue, so intensive photodynamic therapy is possible.

[0041] Referring to FIG. 3, in the stent 300 according to a modified example of the present invention, the rear end portion (distal portion) of the stent 300 can be fixed to the adjustment tube 220 of the catheter 200, and the front end portion (proximal portion) of the stent 300 can be provided in the form of a free end that is not fixed to the guide tip 260 of the catheter 200. In this way, when the front end portion of the stent 300 is provided in the form of a free end to the catheter 200, the stent 300 is arranged in a wider range, so that a wide range of photodynamic therapy is possible.

[0042] The stent 300 can adjust the expansion length E of the stent 300 that is expanded according to the moving distance that the moving tube 240 moves. For example, when the moving tube 240 moves in the rearward direction (the direction in which the pusher pulls), the expansion length E of the stent 300 that is expanded can be increased in proportion to the moving distance of the moving tube 240. Then, when the moving tube 240 is moved forward (the direction in which the pusher pushes), the stent 300 is recovered by the moving tube 240, and the expansion length E of the stent 300 can be shortened.

[0043] The stent 300 can be coated with a photo-responsive agent. The photo-responsive agent can include a substance capable of photodynamic therapy of the diseased site of the tissue when irradiated with a laser. For example, the photo-responsive agent (photosensitizer) can include at least one of Chlorin e6, Hematoporphyrin, Methylene blue, and Toluidine blue.

[0044] The coating film of the photosensitizer is composed of a single layer and can be coated on the stent 300. The thickness of the coating film of the photosensitizer may be thinner than the wire diameter of the stent 300. The photosensitizer can be uniformly coated on the surface of the stent 300. However, when the stent 300 is installed on the coating jig required for coating, since the coating film is formed on the stent 300 in the vicinity of the coating jig, the coating film of the photosensitizer can be coated more on the inner side than on the outer side of the stent 300. However, due to the characteristics of the stent 300, when the stent 300 is located at the diseased site of the tissue, the characteristics that the shape of the stent 300 deforms according to the shape of the tissue and the characteristic that the diseased tissue tries to enter from the outer side to the inner side of the stent 300 act. Therefore, even if the coating film of the photosensitizer is coated more on the inner side than on the outer side of the stent 300, the concern about the photodynamic therapy effect is minimal.

[0045] The optical fiber 400 can enter and exit from the catheter 200 so as to be located at the central part of the stent 300. As an example, the optical fiber 400 may be a cylindrical diffuser. The optical fiber 400 can be electrically connected to a laser supply device (not shown) for irradiating the stent 300 with a laser. The laser supply device can adjust the wavelength, irradiation intensity, and irradiation interval of the laser according to the characteristics of the diseased site of the tissue.

[0046] The optical fiber 400 can move inside the adjustment tube 220. For this purpose, the outer diameter of the optical fiber 400 may be smaller than the inner diameter of the adjustment tube 220. Of course, the outer diameter of the optical fiber 400 may also be smaller than the inner diameter of the moving tube 240.

[0047] Thereby, in a state where the stent 300 is pulled out from the catheter 200 and expanded, the optical fiber 400 can activate the photosensitizer by irradiating the photosensitizer coated on the stent 300 with the laser provided from the laser supply device.

[0048] Next, the operation and effects of the photodynamic therapy catheter device having the above configuration will be described.

[0049] FIG. 4 is a state diagram showing a state in which a guide wire is inserted into a lesion site in a catheter device for photodynamic therapy according to an embodiment of the present invention. FIG. 5 is a state diagram showing a state in which a catheter device for photodynamic therapy according to an embodiment of the present invention is guided to a lesion site along a guide wire. FIG. 6 is an enlarged view showing an enlarged view of a "B" portion of FIG. 5. FIG. 7 is a state diagram showing a state in which a stent of a catheter device for photodynamic therapy according to an embodiment of the present invention is expanded at a lesion site. FIG. 8 is a state diagram showing a state in which an optical fiber is moved inside a stent in a catheter device for photodynamic therapy according to an embodiment of the present invention. FIG. 9 is a state diagram showing a state in which a photodynamic therapy is performed on a lesion site by irradiating a laser toward a photosensitizer of a stent with an optical fiber in a catheter device for photodynamic therapy according to an embodiment of the present invention. FIG. 10 is a state diagram showing a state in which a catheter device for photodynamic therapy according to an embodiment of the present invention is recovered from a lesion site.

[0050] As shown in FIG. 4, first, the guide wire 100 is moved to a lesion site L generated in the tissue of a luminal organ having a malignant stricture disease.

[0051] As shown in FIGS. 5 to 6, when the guide wire 100 is positioned at the lesion site L of the tissue, the catheter 200 is moved to the lesion site L of the tissue via the guide wire 100, so that the stent 300 is positioned corresponding to the lesion site L of the tissue.

[0052] As shown in FIG. 7, when the stent 300 is positioned corresponding to the lesion site L of the tissue, the stent 300 is expanded, brought into close contact with the lesion site L of the tissue, and the guide wire 100 is separated from the catheter 200. For example, when the pressing of the moving tube 240 against the stent 300 is released by the pull operation of the pusher 250 in a state where the stent 300 is arranged corresponding to the lesion site L of the tissue, the stent 300 can be expanded to be in close contact with the lesion site L of the tissue.

[0053] As shown in FIG. 8, when the stent 300 is expanded and adheres to the diseased site L of the tissue, the optical fiber 400 is moved to the diseased site L of the tissue through the catheter 200. At this time, the optical fiber 400 can be located at the center of the expanded stent 300.

[0054] As shown in FIG. 9, when the optical fiber 400 is disposed at the diseased site L of the tissue through the catheter 200, the photosensitizer coated on the stent 300 is activated by irradiating the laser R toward the diseased site L of the tissue through the optical fiber 400, and the photodynamic therapy is advanced.

[0055] As shown in FIG. 10, when the irradiation of the laser toward the diseased site L is completed, the stent 300 is retrieved and separated. At this time, due to the push operation of the pusher 250, the moving tube 240 is pressed against the stent 300, so that the stent 300 can be retrieved into the space between the moving tube 240 and the support tube 210 of the catheter 200.

[0056] As described above, the present invention can kill cells such as cancer and stenosis diseases by photodynamic therapy, and can contribute to the treatment of malignant stenosis diseases by photodynamic therapy by irradiating a laser on the photosensitizer coated on the catheter device to activate the photosensitizer. It has excellent advantages such as being able to be retrieved after photodynamic therapy and the range in which photodynamic therapy is possible being deformable according to the length of the lesion.

[0057] The above has described the embodiments of the present invention as specific examples, but this is merely illustrative and the present invention is not limited thereto. It should be construed as having the broadest scope in accordance with the technical idea disclosed in this specification. Those skilled in the art can implement patterns of shapes not disclosed by combining / substituting the disclosed examples, but this will not deviate from the scope of the present invention. Furthermore, those skilled in the art can easily modify or deform the disclosed examples based on this specification, and it is obvious that such modifications or deformations also belong to the scope of rights of the present invention.

Claims

1. A catheter movable to a diseased site of an organ; A stent installed to be able to enter and exit from an end of the catheter to enable a change in length, and coated with a photosensitizer; An optical fiber capable of entering and exiting the catheter so as to be located at a central portion of the stent; and Including a guide wire installed to be able to enter and exit the catheter and guiding the catheter so that the catheter moves to the diseased site, The optical fiber, After the stent is pulled out of the catheter and expanded, irradiates a laser toward the photosensitizer for activation of the photosensitizer, The catheter, A support tube movable along the guide wire; A moving tube configured to accommodate at least a part of the stent therein and movable along the support tube so that an extended length of the stent protruding outside the catheter is adjusted; An adjustment tube providing a tube passage through which the optical fiber can move inside and supported by the support tube so that at least a part of the stent is disposed outside; and Including a guide tip connected to an end of the adjustment tube and communicating with the tube passage so that the optical fiber can move, The optical dynamic therapy catheter device, wherein an extended length of the stent is adjusted in proportion to a moving distance of the moving tube.

2. The stent, When pressed by the moving tube, is located in a space between the adjustment tube and the moving tube, maintains a crimped state while wrapping the adjustment tube, The optical dynamic therapy catheter device according to claim 1, wherein when the pressing of the moving tube is released, it expands and restores to its original form.

3. A rear end of the stent is fixed to the catheter, The optical dynamic therapy catheter device according to claim 1, wherein a front end of the stent is fixed to the guide tip or provided in a free end form.

4. The stent, In a space between the adjustment tube and the moving tube of the catheter, is provided in a cylindrical net-like form that crimps and wraps the adjustment tube by pressing of the moving tube. The optical dynamic therapy catheter device according to claim 1.

5. The catheter further includes a pusher connected to a rear end of the moving tube, The stent, When the pressing of the moving tube is released as the moving tube moves rearward during the pulling operation of the pusher, the adjusting tube of the catheter is expanded so as to be in close contact with the lesion site, and is recovered to the adjusting tube of the catheter by the pressing of the moving tube in response to the forward movement of the moving tube during the pushing operation of the pusher. The photodynamic therapy catheter device according to claim 4, characterized in that.

6. The photosensitizer is The photodynamic therapy catheter device according to claim 1, characterized in that it contains one or more of chlorin e6, hematoporphyrin, methylene blue, and toluidine blue.

Images