Antiperspirant composition

Abstract

To provide an antiperspirant composition that can act on sweat glands to control the secretion of sweat without closing sweat pores.SOLUTION: An antiperspirant composition contains a specific amount of ammonium glycyrrhizate.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an antiperspirant composition.

Background Art

[0002] The sweat glands of humans are important organs that mainly regulate body temperature by secreting sweat. However, excessive amounts of sweat that are unnecessary for body temperature regulation, as well as the odors generated by the decomposition of sweat by microorganisms and oxidation, can cause discomfort to humans. Therefore, conventionally, as antiperspirants, there are known body odor suppressing cosmetics and antiperspirant cosmetics that contain an antiperspirant component that exhibits a physical antiperspirant effect by blocking sweat pores with metal ions such as aluminum chloride, and further contain a bactericide or antibacterial agent.

[0003] By the way, Patent Document 1 describes that glycyrrhizic acid has an antiperspirant effect.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, although Patent Document 1 reports a sweating suppressant drug containing glycyrrhizic acid as an active ingredient, the sweating suppression effect is not sufficient and there is room for improvement.

[0006] The present invention has been made in view of the above problems, and an object thereof is to provide an antiperspirant composition that can act on sweat glands to control sweat secretion without blocking sweat pores.

Means for Solving the Problems

[0007] As a result of intensive studies to solve the above problems, the present inventors have found that ammonium glycyrrhizinate among glycyrrhizic acid, its derivatives and salts thereof is an especially excellent antiperspirant ingredient.

[0008] That is, the present invention includes the following configurations.

[0009] <1> An antiperspirant composition containing ammonium glycyrrhizinate as an antiperspirant ingredient, wherein the content of the ammonium glycyrrhizinate is 0.05 to 1.00% by mass.

[0010] <2> The antiperspirant composition according to claim 1, containing at least one of ammonium mono-glycyrrhizinate and ammonium di-glycyrrhizinate as the ammonium glycyrrhizinate.

Effects of the Invention

[0011] According to the present invention, it is possible to provide an antiperspirant composition that can act on sweat glands to control sweat secretion without occluding sweat pores.

Modes for Carrying Out the Invention

[0012] The present invention will be described below, but the present invention is not limited thereto. The present invention is not limited to each of the configurations described below, and various modifications are possible within the scope shown in the claims. Also, embodiments or examples obtained by appropriately combining the technical means disclosed in different embodiments or examples are also included in the technical scope of the present invention. Furthermore, by combining the technical means disclosed in each embodiment, new technical features can be formed. All academic documents and patent documents described in this specification are incorporated herein by reference.

[0013] Unless otherwise specified in this specification, "X to Y" representing a numerical range is intended to mean "X or more and Y or less". Also, unless otherwise specified in this specification, the mass% representing the content of a component is a value based on assuming that the total mass of the antiperspirant composition is 100 mass%.

[0014] 〔1. Antiperspirant composition〕 The antiperspirant composition according to the present invention contains ammonium glycyrrhizinate as an active ingredient, and the content of the ammonium glycyrrhizinate is 0.05 to 1.00 mass%.

[0015] According to the antiperspirant composition of the present invention, it is possible to control the secretion of sweat without occluding sweat pores. The present inventor has found that, as shown in International Application No. PCT / JP2019 / 011137, a predetermined compound containing carbenoxolone acts on sweat glands to exhibit an antiperspirant effect without occluding sweat pores. Since the above ammonium glycyrrhizinate has a structure common to carbenoxolone, it is considered to exhibit a similar mechanism of action. Although it has been known that glycyrrhizic acid has an antiperspirant effect, it has not been known that ammonium glycyrrhizinate, which is a salt thereof, exhibits a remarkably high antiperspirant effect, which is surprising. In addition, ammonium glycyrrhizinate is easily dissolved in various solvents.

[0016] If the content of ammonium glycyrrhizinate is 0.05 mass% or more, it is preferable from the viewpoint of suppressing sweating. The content is more preferably 0.10 mass% or more, and even more preferably 0.30 mass% or more. If the content is 1.00 mass% or less, it is preferable from the viewpoint of reducing the burden on the user. The content is more preferably 0.90 mass% or less, and even more preferably 0.80 mass% or less.

[0017] The above antiperspirant composition preferably contains at least one of ammonium monoglycyrrhizinate and ammonium diglycyrrhizinate as ammonium glycyrrhizinate.

[0018] In the antiperspirant composition according to the present invention, other components can be blended as long as the functions of the present invention are not impaired. Examples of the other components include, but are not limited to, water, surfactants, alcohols, cooling agents, plant extracts, fragrances, sequestering agents, antioxidants, preservatives, thickeners and the like.

[0019] Examples of the above surfactants include nonionic surfactants such as alkyl glyceryl ether, polyoxyalkylene alkyl ether, polyoxyalkylene hydrogenated castor oil, glycol fatty acid ester, glycerin fatty acid ester, polyoxyalkylene glyceryl ether fatty acid ester, sorbitan fatty acid ester, polyoxyalkylene sorbitan fatty acid ester, silicone surfactant; anionic surfactants such as alkyl sulfate ester salts, polyoxyethylene alkyl ether sulfates, acyl N-methyl taurine salts, alkyl ether phosphate ester salts, N-acyl amino acid salts; cationic surfactants such as alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride; and amphoteric surfactants such as alkyl dimethylamino acetic acid betaine, alkyl amidopropyl dimethylamino acetic acid betaine.

[0020] Examples of the above alcohol include ethanol and the like.

[0021] Examples of the above cooling agents include menthol, menthyl glyceryl ether, menthyl lactate, peppermint oil, peppermint oil, camphor, ishirin and the like.

[0022] Examples of the above antioxidants include tocopherol and its derivatives, ascorbic acid and its derivatives and the like.

[0023] Examples of the above sequestering agents include edetate salts, phosphoric acid, sodium polyphosphate and the like.

[0024] Examples of the thickener include dextran, pullulan, arabinogalactan, guar gum, tara gum, locust bean gum, konjac mannan, tamarind seed gum, and the like.

[0025] In addition, the antiperspirant composition may or may not contain an antiperspirant component (such as an aluminum compound) that exhibits a physical antiperspirant effect by blocking sweat pores.

[0026] As described above, according to the antiperspirant composition of the present invention, since the ammonium glycyrrhizinate is contained as an active ingredient for controlling the secretion of sweat by sweat glands, it acts on the secretory ducts of sweat glands and can control the movement of the secretory ducts of sweat glands during sweat secretion. Therefore, according to the antiperspirant composition of the present invention, it is possible to control the secretion of sweat by acting on sweat glands without blocking sweat pores.

[0027] [2. Dosage form, manufacturing method, and use of the antiperspirant composition] Examples of the dosage form of the antiperspirant composition according to the present invention include aerosol, lotion, mist, emulsion, gel, cream, stick, sheet, and the like.

[0028] In addition, the commercial form of the antiperspirant composition according to the present invention is not particularly limited, but it can be in a commercial form filled in a pump container, a tube container, a jar container, an aerosol container, or the like.

[0029] The manufacturing method of the antiperspirant composition according to the present invention is not particularly limited, and known manufacturing methods can be used. Examples of the manufacturing method of the antiperspirant composition include a method of mixing the above components and stirring them with a known mixing device such as a propeller mixer, a disperser mixer, or a paddle mixer to homogenize the components.

[0030] The antiperspirant composition according to the present invention is expected to be used, for example, in antiperspirants for cosmetic use, antiperspirants for medical use, and the like. Further, the antiperspirant composition according to the present invention is expected to be used as an antiperspirant that meets the user's requirements, such as an antiperspirant for completely inhibiting sweat secretion and an antiperspirant for relieving sweat secretion.

Examples

[0031] Hereinafter, the present invention will be specifically described with reference to examples, but the embodiments of the present invention are not limited to these examples. The contents in Table 1 are amounts (mass %) converted to pure components.

[0032] 〔Method for measuring sweat inhibition rate〕 At room temperature, the composition shown in Table 1 was applied in a circular shape of 1 cm on the skin of the outer part of the forearm. Next, the lower limbs were soaked in warm water at about 42 ° C to promote sweating. Here, using a sweat meter (equipment name: SKN-2000, manufactured by Nishizawa Electric Instrument Manufacturing Co., Ltd.), the average sweat amount (mg / min) of the portion (sample application portion) where the compositions of the following examples and comparative examples were applied during the period when the sweat amount was stable for 10 minutes was measured. Then, the sweat inhibition rate based on Comparative Example 1 was calculated from the following formula (1). 2 Sweat inhibition rate (%) = 100 - [(average sweat amount of the corresponding example or comparative example other than Comparative Example 1 / average sweat amount of Comparative Example 1) × 100] ··· (1)

[0033] Sweat inhibition rate (%) = 100 - [(average sweat amount of the corresponding example or comparative example other than Comparative Example 1 / average sweat amount of Comparative Example 1) × 100] ··· (1) 〔Examples 1 to 3 and Comparative Examples 1 to 3〕 As shown in Table 1, antiperspirants of Examples 1 to 2 and Comparative Examples 1 to 3 were prepared by blending each component. The measurement results of the sweat inhibition rate are also shown in Table 1.

[0034]

Table 1

[0035] From Table 1, Examples 1 to 4 containing 0.05% by mass or more of ammonium glycyrrhizinate had a higher sweating inhibition rate than Comparative Examples 1 to 3. From this, it was found that ammonium glycyrrhizinate has an effect of suppressing sweating. Also, even among the salts of glycyrrhizic acid, dipotassium glycyrrhizinate did not suppress sweating. Therefore, it can be said that among glycyrrhizic acid and its salts, ammonium glycyrrhizinate effectively suppresses sweating.

Industrial Applicability

[0036] The present invention can be suitably used as an antiperspirant.

Claims

1. An antiperspirant composition containing ammonium glycyrrhizinate as an antiperspirant ingredient, wherein the content of the ammonium glycyrrhizinate is 0.10 to 0.80% by mass, and containing ethanol.

2. The antiperspirant composition according to claim 1, containing at least one of ammonium mono-glycyrrhizinate and ammonium di-glycyrrhizinate as the ammonium glycyrrhizinate.

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