Biotissue adhesive application tool

Abstract

To provide a tissue adhesive application tool capable of suppressing inhibition of discharge of a liquid medicine discharge part.SOLUTION: A tissue adhesive application tool comprises: a plurality of liquid medicine circulation paths (a liquid medicine circulation pipe 3, a liquid medicine circulation pipe 4, a discharge pipe 40) in which a liquid medicine is circulated; and a gas circulation path (2ac) in which a gas is circulated, the gas is used for mixing the liquid medicines discharged from the plurality of liquid medicine circulation paths. Each of the plurality of liquid medicine circulation paths comprises on a tip end part thereof, a liquid medicine discharge part (40) for discharging a liquid medicine, the gas circulation path (2ac) has a gas ejection part (2h) for injecting a gas to the liquid medicine discharged from the liquid medicine discharge part (40) for spraying and mixing the liquid medicines, on a tip end part of the gas circulation path. The liquid medicine discharge part (40) has a peripheral wall (40a) for defining a discharge direction of the liquid medicine. A notch (40b) is formed so as to extend to a tip end of the peripheral wall (40a), and the notch (40b) is arranged on an ejection destination of a gas of the gas ejection part (2h).SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a biological tissue adhesive applicator that mixes a plurality of chemical liquids that function as adhesives for biological tissues and sprays the mixed chemical liquid onto biological tissue to apply the mixed chemical liquid to the biological tissue. [Background technology]

[0002] Conventionally, biological tissue adhesive applicators that spray two mixed chemical solutions have been available. When the chemical solution used in a biological tissue adhesive applicator contains fibrinogen or other substances that are highly viscous and prone to coagulation, the chemical solution may dry out and coagulate near the tip of the nozzle from which it is ejected. In addition, coagulation caused by contact with and mixing with other chemical solutions passing through other chemical solution flow pipes may interfere with the ejection of the chemical solution.

[0003] Patent Document 1 discloses a biological tissue adhesive applicator in which a medical solution flow tube has a communication port as a slit, and is configured so that high-pressure gas enters through the communication port when the discharge of the medical solution stops. This medical tissue adhesive applicator is configured to expel residual medical solution remaining at the tip side of the medical solution flow tube by high-pressure gas. Specifically, when the plunger that sends the liquid medicine into the liquid medicine distribution pipe is stopped from being pushed into the syringe, the liquid medicine further forward than the communication port is expelled from the liquid medicine distribution pipe by the high-pressure gas that enters the liquid medicine distribution pipe, thereby preventing the liquid medicine remaining in the liquid medicine distribution pipe from mixing with the liquid medicine in other liquid medicine distribution pipes.

[0004] This biological tissue adhesive applicator is equipped with a check valve that can prevent bubbles caused by gas mixed in the solution in the drug solution flow pipe from flowing back upstream. This check valve can prevent bubbles from flowing back upstream of the drug solution flow pipe. This check valve is configured to suitably prevent the drug solution that is pushed out toward the tip of the drug solution flow pipe by the expansion of gas bubbles mixed in the drug solution upstream of the drug solution flow pipe from coming into contact with and mixing with other drug solutions and coagulating. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-100851 Summary of the Invention [Problem to be solved by the invention]

[0006] However, with the biological tissue adhesive applicator of Patent Document 1, even if gas was introduced into the drug solution flow pipe from the communication port to discharge the drug solution, it was difficult to completely remove the drug solution that had accumulated at the tip of the drug solution flow pipe. As a result, drug solution 110 would accumulate at the tip of discharge pipe 140 of nozzle body 102 shown in Figure 11, solidify, and clog, thereby hindering the discharge of drug solution 110. Note that Figure 11 is a diagram showing a portion of a conventional nozzle body 102, and is a diagram schematically showing a state in which a lump of semi-hardened drug solution 110 has formed at the tip of discharge pipe 140.

[0007] The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to provide a biological tissue adhesive applicator that can prevent the discharge of a drug solution discharge portion from being obstructed. [Means for solving the problem]

[0008] The biological tissue adhesive applicator of the present invention comprises: a nozzle body having an internal space; a plurality of chemical liquid flow passages through which chemical liquids flow and each of which includes a chemical liquid flow pipe; a gas flow passage through which gas flows for mixing the chemical liquids discharged from the plurality of chemical liquid flow passages; and a nozzle body having an internal space, the nozzle body comprising an outer jacket member, a tip side member attached to the tip of the outer jacket member, and a gas injection part for filling the space with the gas; each of the plurality of chemical liquid flow passages has at its tip a discharge pipe which is a chemical liquid discharge part provided in the tip side member and discharges the chemical liquid; an insertion hole formed at the tip of the outer jacket member through which the discharge pipe is inserted and held; the discharge pipe has a peripheral wall which determines the discharge direction of the chemical liquid; the gas flow passage has a gas jetting part at its tip that jets gas onto the chemical liquid discharged from the discharge pipe to spray and mix the chemical liquid in mist, the tip of the peripheral wall protrudes beyond the tip of the gas jetting part, the space of the nozzle body is provided proximal to the insertion hole and has a flow path cross-sectional area wider than the flow path cross-sectional area of the gas flow passage, the distal end of the space is inclined so as to move away from the chemical liquid flow passage as it moves proximal, and the discharge pipe has a notch formed in it that extends from the tip of the peripheral wall to the space of the nozzle body, and the notch is arranged to face the gas jetting part It is characterized by: [Effects of the Invention]

[0009] The tool for applying a biological tissue adhesive of the present invention can provide a tool for applying a biological tissue adhesive that can prevent the discharge of the drug solution discharge portion from being obstructed. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a perspective view showing a biological tissue adhesive applicator according to an embodiment of the present invention. [Figure 2]2 is a schematic cross-sectional view of a discharge pipe and a gas flow passage portion, taken along line II-II in FIG. 1. FIG. [Figure 3] 3 is a schematic cross-sectional view of a discharge pipe and a gas flow passage portion, taken along line III-III in FIG. 2. FIG. [Figure 4] 4 is a schematic cross-sectional view of a discharge pipe and a gas flow passage portion, taken along line IV-IV in FIG. 3. FIG. [Figure 5] FIG. [Figure 6] 6A and 6B are cross-sectional views taken along the line VI-VI in FIG. 5, where (a) is a cross-sectional view of the balloon in a contracted state, and (b) is a cross-sectional view of the balloon in an expanded state. [Figure 7] FIG. 4 is a schematic cross-sectional view of a discharge pipe and a gas flow passage according to a first modified example, and corresponds to FIG. 3. [Figure 8] FIG. 10 is a schematic cross-sectional view of a discharge pipe and a gas flow passage according to a second modified example, and corresponds to FIG. 3. [Figure 9] FIG. 11 is a perspective view showing a tip side member according to a third modified example. [Figure 10] 10 is a cross-sectional view showing the state in which the tip side member is attached to the outer member, and is a cross-sectional view showing the tip side member and the outer member taken along the line XX in FIG. 9. [Figure 11] FIG. 10 is a diagram showing a part of a conventional nozzle body, and is a diagram showing a state in which a lump of semi-hardened chemical liquid has formed at the tip of the discharge pipe. DETAILED DESCRIPTION OF THE INVENTION

[0011] Hereinafter, an embodiment of the biological tissue adhesive applicator of the present invention will be described with reference to the drawings. The embodiment described below is merely an example to facilitate understanding of the present invention, and is not intended to limit the present invention. In other words, the shapes, dimensions, arrangements, etc. of the components described below may be changed or improved without departing from the spirit of the present invention, and the present invention naturally includes equivalents thereof. In addition, in all the drawings, like components are denoted by like reference numerals, and duplicated explanations will be omitted where appropriate. In addition, hereinafter, the side of the biological tissue adhesive applicator from which the drug solution is ejected will be referred to as the distal end side, and the opposite side will be referred to as the proximal end side.

[0012] <Summary> First, an overview of the tool 1 for applying a biological tissue adhesive according to this embodiment will be described with reference to Fig. 1 to Fig. 3. Fig. 1 is a perspective view showing the tool 1 for applying a biological tissue adhesive according to this embodiment. Fig. 2 is a schematic cross-sectional view of the discharge pipe 40 and the gas flow passage 2ac, taken along II-II in Fig. 1, and Fig. 3 is a schematic cross-sectional view of the discharge pipe 40 and the gas flow passage 2ac, taken along III-III in Fig. 2.

[0013] The tissue adhesive applicator 1 according to this embodiment includes a plurality of liquid medicine flow paths (liquid medicine flow pipes 3, 4 and a discharge pipe 40) through which liquid medicines 10, 11 (see FIG. 3) flow, and a gas flow path 2ac through which a gas flows for mixing the liquid medicines 10, 11 discharged from the plurality of liquid medicine flow paths. Each of the plurality of chemical liquid flow paths has a chemical liquid discharge part (discharge pipe 40) at the tip end thereof for discharging chemical liquids 10 and 11. The gas flow passage 2ac has at its tip a gas ejection part 2h that ejects gas onto the chemical solutions 10, 11 discharged from the chemical solution discharge part (discharge pipe 40) to spray and mix the chemical solutions 10, 11 in mist form. The chemical solution discharge part (discharge pipe 40) has a peripheral wall 40a that determines the discharge direction of the chemical solutions 10 and 11, and a notch 40b is formed in the peripheral wall 40a up to the tip of the peripheral wall 40a. The notch 40b is located at the gas outlet of the gas ejection part 2h. According to the above configuration, the chemical solutions 10, 11 (and semi-hardened chemical solutions 10, 11) accumulated at the tip of the chemical solution discharge part (discharge pipe 40) can be blown away by gas entering the inside of the chemical solution discharge part (discharge pipe 40) from the notch 40b. Therefore, even if the chemical solutions 10, 11 are sprayed intermittently multiple times, clumps of the chemical solutions 10, 11 do not grow into icicles in the chemical solution discharge part, and clogging of the chemical solution discharge part can be prevented.

[0014] Specifically, when a side hole (not shown) that is not cut all the way to the tip is formed in the peripheral wall 40a of the liquid chemical discharge portion (discharge pipe 40), gas flow may be difficult to generate near the tip wall side of the side hole where the gas enters. In this case, liquid chemicals 10 and 11 tend to accumulate in the liquid chemical discharge portion. On the other hand, when the notch 40b is formed in the liquid chemical discharge part (discharge pipe 40) that extends to the tip of the peripheral wall 40a, the formation of a dead space where gas flow is difficult can be suppressed, and therefore, the liquid chemicals 10 and 11 can be prevented from accumulating at the tip of the liquid chemical discharge part (discharge pipe 40).

[0015] <Overall structure> The overall configuration of a biological tissue adhesive applicator 1 according to this embodiment will be described with reference to FIGS.

[0016] The biological tissue adhesive applicator 1 according to this embodiment has the function of spraying and mixing a plurality of (two types in this embodiment) medicinal liquids 10, 11 (described below) at the destination of the ejection, and applying the mixture as an adhesive to organs or the like in a living body. The biological tissue adhesive applicator 1 comprises a nozzle body 2 having a medicinal liquid ejection portion (ejection pipe 40) that ejects the medicinal liquids 10, 11, and a plurality of medicinal liquid circulation paths (medical liquid circulation tubes 3 and 4) that pass through an internal space 2s of the nozzle body 2 and circulate the medicinal liquids 10, 11. The medicinal liquid circulation tubes 3 and 4 each communicate between a syringe attachment port 2d, which serves as a medicinal liquid injection portion provided in the nozzle body 2, and the medicinal liquid ejection portion (ejection pipe 40) provided at the tip of the nozzle body 2. Furthermore, two plungers 7 and two syringes 17 are attached to the nozzle body 2 for introducing different medicinal solutions 10 and 11 into the nozzle body 2. The tissue adhesive applicator 1 also includes a plunger holder 8 for simultaneously pushing the two plungers 7 into the syringes 17.

[0017] An air supply tube 31 is connected to the tissue adhesive applicator 1, which introduces air supply gas for spraying the medicinal solutions 10 and 11 into the nozzle body 2. The air supply tube 31 is connected to a regulator 30 that adjusts the amount of air supply gas, and is connected to the nozzle body 2 via an air filter 9. Specifically, the air supply tube 31 is connected to the regulator 30 by a connector 31a provided on the base end side, and is connected to a connection port 9a of the air filter 9 by a connector 31b provided on the tip side.

[0018] <Configuration around the nozzle body> Next, the configuration around the nozzle main body 2 will be described with reference mainly to FIGS. The tissue adhesive applicator 1 includes a nozzle body 2 having an internal space, and the nozzle body 2 has a gas injection section 2g (see FIG. 1) for filling the space 2s with gas. A plurality of liquid medicine flow paths (liquid medicine flow pipes 3, 4) pass through the space 2s inside the nozzle body 2, and the space 2s is connected to a gas flow path 2ac. The nozzle body 2 is mainly composed of a tapered outer sheath member 2a, a plate-shaped base end side member 2b attached to the base end of the outer sheath member 2a, and a tip side member 2c attached to the tip end of the outer sheath member 2a from the inside.

[0019] As shown in Fig. 1, the mantle member 2a has a portion that protrudes obliquely upward and backward, and at the tip of the portion is formed a gas inlet 2g for filling the space 2s inside the nozzle body 2 with a supply gas. The supply gas is introduced from a regulator 30 through an air supply tube 31, an air filter 9, and the gas inlet 2g into and fills the space 2s inside the nozzle body 2. As shown in Fig. 2, a support portion 2aa (described later) for supporting a discharge pipe 40 (described later) is provided at the tip of the mantle member 2a.

[0020] Two portions protrude rearward from the base-end member 2b, and syringe mounting ports 2d serving as liquid medicine injectors are formed at the rear ends of these portions. A syringe 17 is connected to each of the two syringe mounting ports 2d. Base ends 3a and 4a of liquid medicine flow pipes 3 and 4, which will be described later, are connected to the front ends of the liquid medicine flow paths that pass through the two syringe mounting ports 2d in the base-end member 2b. In other words, when the plungers 7 are pushed into the syringes 17, the liquid medicines 10 and 11 filled in the two syringes 17 respectively pass through the liquid medicine flow pipes 3 and 4 in the nozzle body 2 via the syringe mounting ports 2d.

[0021] <About chemical liquid distribution pipes> The chemical solution flow pipes 3 and 4 are arranged to pass through the space 2s inside the nozzle body 2, and are used to flow two types of chemical solutions to be mixed. In this embodiment, the chemical solution flow pipe 3 is used to flow a chemical solution 10 (see FIG. 3) that contains fibrinogen and the like and has high viscosity and is easily coagulated. The chemical solution flow pipe 4 is used to flow a chemical solution 11 that contains thrombin and the like and acts on fibrinogen and the like to function as an adhesive. Specifically, the liquid medicine flow pipes 3 and 4 communicate with two syringe mounting ports 2d provided on the base-end member 2b of the nozzle body 2, into which the liquid medicines 10 and 11 are introduced, and with the liquid medicine discharge portions of two discharge pipes 40, which will be described later, provided at the tip of the nozzle body 2. The liquid medicine flow pipe 3 is provided with a balloon 3c, which will be described later, that contracts due to external pressure caused by the introduction and filling of the supply gas into the space 2s from the gas injection portion 2g, and restores its original shape when the external pressure decreases to a predetermined value.

[0022] In the following, a configuration will be described in which a balloon 3c is provided as an expansion / contraction section in a portion of the drug solution flow tube 3, but the present invention is not limited to a configuration in which an expansion / contraction section is provided only in a portion of the drug solution flow tube 3, and includes a configuration in which the drug solution flow tube 3 expands and contracts as a whole. For example, the drug solution flow tube 3 may be a member made entirely of an elastic material such as an elastomer.

[0023] 2, the inner diameter of the drug solution flow pipe 3 having the balloon 3c according to this embodiment is larger than the inner diameter of the drug solution flow pipe 4. By forming the drug solution flow pipes 3 and 4 in this manner, it is possible to reduce the difference between the discharge amount of the drug solution 10 (see FIG. 3) flowing through the drug solution flow pipe 3 and the discharge amount of the drug solution 11 flowing through the drug solution flow pipe 4 when the balloon 3c is deflated, as will be described later. Instead of adjusting the inner diameter ratio of the chemical solution flow pipes 3, 4 in this way, the inner diameters of these pipes may be kept the same and the concentrations of the chemical solutions 10, 11 passing through the chemical solution flow pipes 3, 4 may be adjusted. Needless to say, the inner diameter ratio of the chemical solution flow pipes 3, 4 may also be changed depending on the mixture ratio determined to function as an adhesive.

[0024] The tip side member 2c is composed of two discharge pipes 40 for discharging the chemical solutions 10 and 11 from the chemical solution flow pipes 3 and 4, and a holding member 2ca for holding the two discharge pipes 40. The two discharge pipes 40 are disposed by being inserted through insertion holes 2ab formed at the tip of the outer jacket member 2a. The distal ends 3b, 4b of the chemical solution flow pipes 3, 4 are connected to the base end of the discharge pipe 40. In other words, the chemical solutions 10, 11 that have passed through the two chemical solution flow pipes 3, 4 are introduced into the two discharge pipes 40, respectively.

[0025] The tip of the discharge pipe 40 is a liquid medicine discharge portion that discharges the liquid medicines 10 and 11 to the outside. In other words, the gas ejection portion 2h around the discharge pipe 40 in the insertion hole 2ab is located near the two liquid medicine discharge portions. Therefore, when the supply gas filled in the space 2s from the gas injection portion 2g is ejected to the outside from the gas ejection portion 2h, the liquid medicines 10 and 11 discharged from the liquid medicine discharge portions (discharge pipe 40) of the liquid medicine flow pipes 3 and 4 are sprayed and mixed in a mist. Furthermore, since the chemical solution flow pipes 3 and 4 are arranged within the space 2s of the nozzle body 2, the chemical solutions 10 and 11 discharged from the chemical solution flow pipes 3 and 4, respectively, can be sprayed and mixed approximately evenly by the supply gas ejected from the space 2s through the gas ejection part 2h.

[0026] <Configuration of the chemical solution discharge unit> Next, the configuration around the chemical solution discharge part (discharge pipe 40) according to this embodiment will be described with reference to Fig. 4 in addition to Figs. 1 to 3. Fig. 4 is a schematic cross-sectional view of the discharge pipe 40 and the gas flow passage 2ac, taken along the line IV-IV in Fig. 3.

[0027] The discharge pipe 40 is supported by the support portion 2aa. An insertion hole 2ab is formed in the support portion 2aa, penetrating in the front-rear direction and communicating between the outside and the internal space 2s. The insertion hole 2ab is a through-hole for inserting and holding the discharge pipe 40, which will be described later. As shown in FIG. 3, a part of the insertion hole 2ab serves as a gas flow passage 2ac through which the supply gas passes, between the wall surface forming the insertion hole 2ab and the discharge pipe 40. Specifically, the mantle member 2a according to this embodiment has four protruding ribs 2ad that are evenly arranged in the circumferential direction of the insertion hole 2ab and protrude toward the center of the insertion hole 2ab when viewed in the axial direction as shown in Fig. 3. The four protruding ribs 2ad abut against and hold the circumferential surface of the discharge pipe 40, and form a gas flow passage 2ac between the discharge pipe 40 and recesses adjacent to the protruding ribs 2ad. The tip of the insertion hole 2ab functions as a gas ejection part 2h that ejects the supply gas filled in the space 2s from the periphery of the discharge pipe 40 to the outside. Although the discharge pipe 40 according to this embodiment is separate from the chemical liquid flow pipes 3 and 4, the present invention is not limited to this configuration and they may be formed integrally. Furthermore, the chemical liquid flow pipes 3 and 4 and the discharge pipe 40 are collectively referred to as the chemical liquid flow passage according to the present invention.

[0028] The tip of the chemical solution discharge part (discharge pipe 40) is disposed within a range from the same position as the gas jetting part 2h to a position distal to the gas jetting part 2h at a distance three times the inner diameter of the discharge pipe 40 (1.5 mm in this embodiment), more preferably a distance equal to the inner diameter of the discharge pipe 40 (0.5 mm in this embodiment). Note that "a distance equal to the inner diameter of the discharge pipe 40" also includes a distance that is approximately equal, with a difference of about 0.3 mm. In this way, if the tip of the discharge pipe 40 is arranged within a range from the same position as the gas ejection section 2h to a position distal to the gas ejection section 2h by a distance three times the inner diameter of the discharge pipe 40, the medicinal liquid 10 that has adhered to the tip of the discharge pipe 40 and solidified can be effectively blown outward by the gas ejected from the gas ejection section 2h. For example, when a medicinal liquid 10 containing fibrinogen and a medicinal liquid 11 containing thrombin are mixed together, they change into one containing fibrin, which remains as a lump at the tip of the discharge pipe 40, and can be prevented from accumulating and expanding. In particular, if the tip of the discharge pipe 40 is arranged within a range from the same position as the gas ejection section 2h to a position distal to the gas ejection section 2h by a distance equal to the inner diameter of the discharge pipe 40, it will be possible to effectively blow off the solidified medicinal liquid 10 to the outside even when the medicinal liquids 10 and 11 are repeatedly sprayed.

[0029] As described above, the liquid medicine discharge part (discharge pipe 40) has a peripheral wall 40a that determines the discharge direction of the liquid medicines 10 and 11, and a notch 40b is formed in the peripheral wall 40a up to the tip thereof. As shown in FIG. 4, the notch 40b is formed obliquely with respect to the axial direction of the chemical solution discharge portion, and extends from the tip of the peripheral wall 40a to the inside of the gas flow passage 2ac. In this way, notch 40b extends from the tip of peripheral wall 40a to the inside of gas flow passage 2ac, so that the high-pressure gas in gas flow passage 2ac before being ejected from gas ejection part 2h enters the inside of the chemical liquid flow passage (inside peripheral wall 40a of discharge pipe 40) through notch 40b. In other words, the gas entering through notch 40b can effectively blow away chemical liquids 10, 11 and semi-hardened chemical liquids 10, 11 accumulated at the tip of discharge pipe 40.

[0030] Moreover, because notch 40b is formed obliquely with respect to the axial direction of the liquid chemical discharge portion (discharge pipe 40), the tip of the liquid chemical discharge portion where liquid chemicals 10 and 11 accumulate can be made smaller than the base end side. Furthermore, because gas enters the inside of the liquid chemical flow passage (inside peripheral wall 40a of discharge pipe 40) obliquely along notch 40b, liquid chemicals 10 and 11 accumulated at the tip of the liquid chemical discharge portion are effectively blown away by the gas from the tip of the liquid chemical discharge portion. More specifically, the cutout surface that defines the cutout 40b is formed obliquely with respect to the axial direction of the liquid chemical discharge portion (discharge pipe 40) when viewed from a direction perpendicular to the axial direction of the liquid chemical discharge portion. The phrase "the notch 40b is formed obliquely with respect to the axial direction of the liquid chemical discharge portion" specifically means that the notch surface is formed obliquely. More specifically, it means that the normal direction to the notch surface has both an axial component and a radial component of the liquid chemical discharge portion (discharge pipe 40).

[0031] The notches 40b formed in each of the pair of chemical solution discharge portions (discharge pipes 40) are formed in a direction different from the direction toward the other of the pair of chemical solution discharge portions when viewed from the axial direction of the chemical solution discharge portion. Specifically, the notch 40b in this embodiment is provided on the side away from the other of the pair of chemical solution discharge portions when viewed from the axial direction of the chemical solution discharge portions as shown in Figure 3, and is formed with a notch surface that is obliquely inclined with respect to a line connecting the centers of the pair of chemical solution discharge portions. In this way, notch 40b is formed in a "direction different from the direction toward the other of the pair of chemical solution discharge portions" when viewed from the axial direction of the chemical solution discharge portion, that is, in a position different from the portion of peripheral wall 40a on the line connecting the centers of the pair of chemical solution discharge portions. According to the above configuration, the chemical solutions 10 and 11 are prevented from scattering straight from the notch 40b from one of the pair of chemical solution discharge portions to the other, and the two liquids are prevented from mixing and hardening in the chemical solution discharge portion itself.

[0032] <About balloons> Next, the configuration and function of the balloon 3c as an expansion / contraction section provided in the drug solution flow pipe 3 according to this embodiment will be described with reference to Fig. 5 and Fig. 6 in addition to Fig. 1 to Fig. 4. Fig. 5 is an enlarged view showing the balloon 3c, Fig. 6 is a cross-sectional view taken along line VI-VI in Fig. 5, Fig. 6(a) is a cross-sectional view of the balloon 3c in a contracted state, and Fig. 6(b) is a cross-sectional view of the balloon 3c in an expanded state.

[0033] At least one of the multiple (two in this embodiment) drug solution flow paths (drug solution flow pipes 3, 4) is provided with an expansion / contraction section (balloon 3c) that contracts due to external pressure caused by gas being introduced into space 2s from gas injection section 2g and restores its original shape when the external pressure decreases. According to the above configuration, the expansion / contraction section (balloon 3c) can suck back the medicinal liquid 10, as will be described in detail later, thereby further preventing the medicinal liquid 10 from accumulating at the tip of the medicinal liquid discharge section (discharge pipe 40).

[0034] The balloon 3c allows the medicinal liquid 10 to pass through even in the contracted state shown in Figure 6(a), and by changing from the contracted state to the expanded state shown in Figure 6(b), it has the function of pulling the medicinal liquid 10 back (suction back) from the medicinal liquid discharge section (discharge pipe 40) to the balloon 3c side. Specifically, the balloon 3c has a structure that ensures an internal space with a flow path cross-sectional area A1 so that the medicinal liquid 10 can pass through even when the balloon 3c is contracted by the external pressure of the air supply gas in the space 2s when spraying the medicinal liquid 10 from the biological tissue adhesive applicator 1. In other words, the balloon 3c is configured so that, in the contracted state, part of the inner surface abuts but is not completely closed. The detailed configuration will be described later. Note that the "flow path cross-sectional area" refers to the cross-sectional area of the part through which the medicinal liquid 10 can flow in a cross section perpendicular to the flow direction of the medicinal liquid 10.

[0035] Furthermore, when the injection of the air supply gas into the space 2s is stopped and the external pressure is reduced, the balloon 3c expands by elastic recovery so that the internal space becomes larger, returning to its natural cylindrical shape and having a flow path cross-sectional area A2. The balloon 3c has the function of drawing the medicinal solution 10 back toward the balloon 3c from the tip of the discharge pipe 40 connected to the medicinal solution flow pipe 3 due to pressure fluctuations caused by the expansion and increase in the volume of the internal space.

[0036] Furthermore, the balloon 3c is formed so that, in its expanded state, its flow path cross-sectional area is larger than that of other portions of the liquid medicine flow pipe 3. By forming the balloon 3c in this manner, the liquid medicine 10 can be effectively drawn into the balloon 3c from the tip of the discharge pipe 40. This also makes it possible to prevent the liquid medicine 10 from passing through the adjacent liquid medicine flow pipe 4 and mixing with the liquid medicine 11 remaining in the liquid medicine discharge portion (discharge pipe 40). Furthermore, the expansion / contraction section according to the present invention is preferably one that expands more than its surroundings, like the balloon 3c according to this embodiment. However, the expansion / contraction section according to the present invention is not limited to this configuration, and may be one that is formed flat overall, contracts when external pressure is applied from the insufflation gas, and returns to its original shape when the external pressure weakens.

[0037] The balloon 3c has corrugated recesses 3ca on its outer surface as contraction-promoting sections, and is formed with a thin wall in some areas. As shown in Fig. 5, the corrugated recesses 3ca are formed in pairs on the front and back surfaces of the balloon 3c, in a total of eight locations, parallel to the axial direction of the drug solution flow pipe 3, as will be described later. In this way, the corrugated recesses 3ca are formed and the portions of the balloon 3c are thin-walled, so that these portions are more easily crushed than other portions by the external pressure applied by the insufflation gas. Furthermore, since the wavy recesses 3ca are formed on the outer surface of the balloon 3c, rather than on the inner surface thereof, they are prevented from interfering with the smooth flow of the medicinal solution 10 passing through the inside of the balloon 3c. In this regard, it is preferable that the outer surface of the balloon 3c has a wave-shaped recess 3ca, but the present invention is not limited to this configuration. In other words, as long as the contraction of the balloon 3c is promoted more than in other parts, a recess may be formed on the inner surface. Furthermore, as long as the recess is thin, it is not limited to a recess, and it may be formed to protrude from the surrounding area. Furthermore, only a portion of the balloon 3c may be made of a material with low rigidity.

[0038] Furthermore, the deflation promoter according to the present invention is not limited to a concave depression such as the corrugated recess 3ca, as long as it functions to make the balloon 3c more easily collapsed by the external pressure of the insufflation gas. For example, it may be a notch formed in a part of the surface of the balloon 3c. This notch reduces the reaction force against the bending stress applied to the balloon 3c by the insufflation gas, thereby facilitating the deflation of the balloon 3c.

[0039] As shown in FIG. 5, the corrugated recess 3ca is formed non-circularly, extends in the circumferential direction, and is formed in an undulating manner so as to repeatedly move close to and away from the syringe mounting port 2d and the liquid medicine discharge portion (discharge pipe 40). Specifically, as shown in FIG. 6, the wavy recesses 3ca are formed in pairs on the outer surface of the balloon 3c at positions that are symmetrical with respect to a plane that includes the axis of the balloon 3c. The wavy recess 3ca extends in the circumferential direction of the balloon 3c so as to repeatedly approach and move away from the syringe mounting port 2d and the drug solution discharge portion, in other words, so as to be alternately curved and shifted in the axial direction of the balloon 3c. On the other hand, in other parts of the balloon 3c where the wavy recesses 3ca are not formed, there are parts that are formed continuously in the axial direction so as not to completely obstruct the flow of the medicinal solution 10 when the balloon 3c is contracted.

[0040] By providing the wavy recesses 3ca to the balloon 3c, when external pressure from the supplied gas is applied to the balloon 3c, the pair of wavy recesses 3ca bend and deform around both ends of the wavy recesses 3ca in the circumferential direction of the balloon 3c, as shown in Fig. 6(a), and the inner surfaces of the balloon 3c corresponding to the positions of the wavy recesses 3ca come into contact with each other. On the other hand, since the other parts of the corrugated recess 3ca have a relatively higher rigidity than the corrugated recess 3ca, the inner surfaces of these other parts do not come into contact with each other, thereby making it possible to ensure a flow path for the drug solution 10 inside. Since the corrugated recesses 3ca are formed non-circularly, easily crushed portions and less easily crushed portions of the balloon 3c are locally provided in the circumferential direction. Therefore, when the insufflation gas is filled into the space 2s and the medicinal liquid 10 is being sprayed, as shown in Fig. 6(a), the inside of the balloon 3c is not completely blocked, thereby preventing the flow of the medicinal liquid 10 passing through the inside of the balloon 3c from being obstructed.

[0041] Furthermore, the undulating shape of the corrugated recesses 3ca can prevent the flow of the gas flowing from the gas injection section 2g toward the gas ejection section 2h along the direction connecting the syringe attachment opening 2d and the liquid medicine ejection section (ejection pipe 40) from being obstructed around the corrugated recesses 3ca. Here, the portions of the corrugated recesses 3ca that are close to the gas ejection section 2h and the liquid medicine ejection section are referred to as apexes 3cb. In this embodiment, four apexes 3cb are provided. A portion of the insufflation gas flowing around the balloon 3c comes into contact with the wall surface of the corrugated recesses 3ca, and then gathers at the peaks 3cb, before dispersing to the four peaks 3cb. Therefore, the corrugated recesses 3ca can prevent the flow of insufflation gas from being significantly disrupted, compared to when recesses are formed linearly in the circumferential direction of the balloon 3c. Therefore, the corrugated recesses 3ca can ensure the flow straightening of the insufflation gas and prevent it from affecting the direction of the insufflation gas ejected from the gas ejection port 2h.

[0042] On the other hand, the contraction promoting portion according to the present invention is not limited to a portion having a wave-shaped recess like the wave-shaped recess 3ca, as long as it does not impede the flow straightening of the insufflation gas. For example, the contraction promoting portion formed on the balloon 3c may be a recess extending along the axial direction of the drug solution flow tube 3.

[0043] When the supply of the air supply gas is stopped to stop the discharge of the medicinal solutions 10, 11 while the medicinal solution is being intermittently discharged from the biological tissue adhesive applicator 1, the external pressure acting on the balloon 3c decreases. As a result, the balloon 3c returns to its natural state and expands until the flow path cross-sectional area A1 of the balloon 3c becomes the flow path cross-sectional area A2, and the pressure inside the balloon 3c becomes negative. As a result, the remaining medicinal solution 10 at the tip end of the discharge pipe 40 and the medicinal solution flow tube 3 returns to the balloon 3c side, making it possible to prevent clogging of the medicinal solution 10 at the tip end of the discharge pipe 40 with a simple structure at low cost without using a check valve.

[0044] Furthermore, when the discharge of the medicinal liquids 10 and 11 is resumed, if the regulator 30 injects (supplies) the air supply gas into the space 2s, the external pressure applied to the balloon 3c increases, causing the balloon 3c to contract to a predetermined size. The pressure applied to the medicinal liquid 10 by the contraction of the balloon 3c pushes the medicinal liquid 10 out of the balloon 3c to the position of the tip of the discharge pipe 40 before the expansion of the balloon 3c, thereby reducing the gap between the tip of the discharge pipe 40 and the medicinal liquid 10. Therefore, when the injection of the medicinal liquid 10 is resumed by the plunger 7, the medicinal liquid 10 is smoothly discharged from the medicinal liquid discharge portion (discharge pipe 40), allowing for restart by low-pressure spraying and improving operability.

[0045] Although balloons 3c may be provided in both the chemical liquid flow pipes 3 and 4, providing balloon 3c only in the chemical liquid flow pipe 3 also sufficiently prevents the chemical liquid 11 from passing through the other chemical liquid flow pipe 4 and mixing with the chemical liquid 11 remaining in the chemical liquid discharge section (discharge pipe 40), thereby reducing costs. In particular, it is preferable that the balloon 3c is provided in the drug solution flow pipe 3 through which the drug solution 10 containing highly viscous fibrinogen or the like flows. With this configuration, after the balloon 3c expands and draws the drug solution 10 toward the balloon 3c, the drug solution 10 can be prevented from unexpectedly returning to the drug solution discharge portion (discharge pipe 40) due to its own weight by the viscosity of the drug solution 10. Furthermore, it is also possible to prevent the drug solution 10 containing fibrinogen or the like from coagulating by itself when exposed to the outside from the drug solution discharge portion.

[0046] Furthermore, the balloon 3c is not limited to being formed integrally with the drug solution flow pipe 3, but may be a separate body. In this case, it is preferable that the drug solution flow pipe 3 is made of a harder material than the material of the balloon 3c. With this configuration, the flow of the drug solution 10 in the drug solution flow pipe 3 can be ensured while the expansion and contraction of the balloon 3c can be suitably performed.

[0047] <About modified examples> Next, discharge pipes 50 and 60 according to modifications will be described with reference to Figures 7 and 8 in addition to Figures 1 to 6. Figure 7 is a schematic cross-sectional view of a discharge pipe 50 and a gas flow passage 2ac according to a first modification, and corresponds to Figure 3. Figure 8 is a schematic cross-sectional view of a discharge pipe 60 and a gas flow passage 2ac according to a second modification, and corresponds to Figure 3.

[0048] The notches according to the first and second modifications are slits 50b, 60b that penetrate the peripheral walls 50a, 60a in the thickness direction and extend to the tip in the axial direction of the chemical solution discharge portion (discharge pipe 50, 60). 7, in the discharge pipes 50 according to the first modification, one slit 50b is formed in each of the pair of discharge pipes 50 on the side away from the other discharge pipe 50. The slit 50b is formed in a direction offset from the direction connecting the centers of both discharge pipes 50 (left-right direction). On the other hand, as shown in Fig. 8, two slits 60b are formed in each of a pair of discharge pipes 60 according to the second modification. The two slits 60b in each discharge pipe 60 are arranged so as to intersect with the direction (left-right direction) connecting the centers of the discharge pipes 60. In particular, the two slits 60b in each discharge pipe 60 are arranged on the same straight line passing through the axis of the discharge pipe 60 when viewed in the axial direction of the discharge pipe 60 (in other words, at positions symmetrical with respect to the axis of the discharge pipe 60). With this configuration, gas enters the discharge pipe 60 from the slits 60b provided on opposite sides of the peripheral wall 60a of the discharge pipe 60, and it becomes possible to effectively blow away the chemical solutions 10 and 11 adhering to the inner surface of the peripheral wall 60a.

[0049] In this way, since the notches are slits 50b, 60b, the gas flow passage 2ac can be limited other than between the inner wall surface of the insertion hole 2ab and the discharge pipes 50, 60, and interference with the discharge direction of the chemical solutions 10, 11 discharged in the axial direction can be suppressed. The "axial direction of the chemical solution discharge portion" may have an axial direction component, and includes a direction intersecting a direction parallel to the axial direction.

[0050] A pair of chemical liquid flow paths (chemical liquid flow pipes 3, 4) are provided, and notches (slits 50b, 60b) are formed in each of the chemical liquid discharge portions (discharge pipes 50, 60) provided in the pair of chemical liquid flow paths. The notches (slits 50b, 60b) formed in the pair of chemical solution discharge portions are formed symmetrically with respect to the mid-plane of the pair of chemical solution discharge portions. In this way, the notches (slits 50b, 60b) are formed symmetrically with respect to the mid-plane of the pair of chemical solution discharge portions, so that the chemical solutions 10, 11 discharged from the pair of chemical solution discharge portions can be sprayed symmetrically, thereby allowing the chemical solutions 10, 11 to be effectively mixed. It should be noted that the term "pair" in the above does not necessarily mean two pieces of the same shape, but may also mean two pieces of different shapes. Furthermore, the number of slits is not limited to one or two per discharge pipe, but may be multiple, and is not limited to being on the same straight line passing through the axis when viewed in the axial direction.

[0051] Finally, a tip side member 12c having discharge pipes 70, 71 according to a third modification will be described with reference mainly to Figures 9 and 10. Figure 9 is a perspective view showing the tip side member 12c according to a third modification, and Figure 10 is a cross-sectional view of the tip side member 12c attached to the outer member 2a, and is a cross-sectional view showing the tip side member 12c and the outer member 2a at cross section XX in Figure 9. The tip side member 12c of this modified example is composed of a discharge pipe 70 having a slit 70b, a discharge pipe 71 that has no slit and is formed in a cylindrical shape, and a holding member 12ca that connects and holds these together.

[0052] The notch (slit 70b) according to this modification extends linearly from the tip of the peripheral wall 70a of the discharge pipe 70 through the gas flow passage 2ac to the space 2s inside the nozzle body 2. More specifically, the space 2s is provided at a position facing the side surface of the discharge pipe 70 and is located closer to the base end than the support portion 2aa that supports the discharge pipe 70 by the protruding rib 2ad shown in Fig. 3. The space 2s has a larger flow path cross-sectional area than the gas flow path 2ac that is located between the inner wall surface of the insertion hole 2ab and the side surface of the discharge pipe 70. With this configuration, the supply gas can easily flow into the slit 70b from the space 2s having a larger flow path cross-sectional area than the gas flow passage 2ac, so that the supply gas can effectively blow away the chemical solution 10 remaining at the tip of the discharge pipe 70.

[0053] In particular, it is more preferable if the distal end 2ae of the inner wall surface of the nozzle body 2 (outer jacket member 2a) that defines the space 2s is inclined (or curved) so as to approach the slit 70b toward the tip side. With this configuration, the insufflation gas in the space 2s can be guided by the distal end 2ae toward the inside of the discharge pipe 70 through the slit 70b, and the medicinal solution 10 remaining at the tip of the discharge pipe 70 can be suitably blown away by the insufflation gas.

[0054] The above embodiment encompasses the following technical ideas. (1) a plurality of chemical solution flow paths through which chemical solutions flow; a gas flow passage through which a gas for mixing the chemical liquids discharged from the plurality of chemical liquid flow passages flows, each of the plurality of chemical liquid flow paths has a chemical liquid discharge portion at a tip end thereof for discharging a chemical liquid; the gas flow passage has a gas ejection part at a tip end thereof that ejects gas into the chemical solution discharged from the chemical solution ejection part to spray and mix the chemical solution in a mist form; the chemical solution discharge portion has a peripheral wall that defines a discharge direction of the chemical solution, A notch is formed in the peripheral wall until it reaches the tip of the peripheral wall, The tissue adhesive applicator is characterized in that the notch is disposed at the gas outlet of the gas outlet portion. (2) The tissue adhesive applicator according to (1), wherein the notch extends from the tip of the peripheral wall to the inside of the gas flow passage. (3) The tissue adhesive applicator according to (1) or (2), wherein the notch is formed obliquely with respect to the axial direction of the drug solution discharge portion. (4) The tissue adhesive applicator according to (1) or (2), wherein the notch is a slit extending in the axial direction of the drug solution discharge portion. (5) The chemical solution flow passage is provided in pairs, the notches are formed in the respective chemical solution discharge portions provided in the pair of chemical solution flow paths, The tissue adhesive applicator according to any one of (1) to (4), wherein the notches formed in the pair of medicinal solution discharge portions are formed symmetrically with respect to the mid-plane of the pair of medicinal solution discharge portions. (6) A biological tissue adhesive applicator according to any one of (1) to (5), wherein the notches formed in each of the pair of drug solution discharge portions are formed in a direction different from the direction toward the other of the pair of drug solution discharge portions when viewed from the axial direction of the drug solution discharge portion. (7) Further comprising a nozzle body having a space therein, the nozzle body has a gas injection portion for filling the space with the gas, the plurality of chemical liquid flow paths pass through the space inside the nozzle body, the space is connected to the gas flow passage, The biological tissue adhesive applicator according to any one of (1) to (6), wherein at least one of the drug solution flow passages is provided with an expansion / contraction section that contracts due to external pressure caused by the gas being introduced into the space from the gas injection section and restores its original shape when the external pressure decreases. (8) Further comprising a nozzle body having a space therein, the nozzle body has a gas injection portion for filling the space with the gas, the space is connected to the gas flow passage, The tissue adhesive applicator according to any one of (1) to (7), wherein the notch extends from the tip of the peripheral wall to the space. (9) A tissue adhesive applicator according to any one of (1) to (8), wherein the tip of the liquid medicine discharge part is disposed within a range from the same position as the gas ejection part to a position distal to the gas ejection part by a distance equal to the inner diameter of the liquid medicine discharge part. (10) A tissue adhesive applicator according to (8), wherein the distal end of the inner wall surface of the nozzle body defining the space is inclined or curved so as to approach the notch as it moves toward the tip. [Explanation of symbols]

[0055] 1. Biotissue adhesive application tool 2 Nozzle body 2a Mantle member 2aa support part 2ab insertion hole 2ac gas flow passage 2ad protruding rib 2ae distal end 2b Base end member 2c Tip side member 2ca holding member 2d Syringe attachment port (medicinal solution injection part) 2g Gas injection section 2h Gas outlet 2s space 3, 4 Chemical flow pipe (chemical flow path) 3a, 4a proximal end 3b, 4b Tip 3c Balloon (expansion part) 3ca Wave recess (shrinkage promotion section) 3cb top 7 Plunger 8 Plunger holder 9. Air Filter 9a Connection port 10, 11 Chemical solutions 12c Tip side member 12ca holding member 17 Syringe 30 Regulator 31 Air supply tube 31a, 31b connectors 40, 50, 60, 70, 71 Discharge pipe (chemical discharge part, chemical flow path) 40a, 50a, 60a, 70a Peripheral wall 40b Notch (notch surface) 50b, 60b, 70b slit (notch) 102 Nozzle body 110 Chemical Solution 140 discharge pipe

Claims

1. a plurality of chemical solution flow paths through which the chemical solution flows, each including a chemical solution flow pipe; a gas flow passage through which a gas for mixing the chemical liquids discharged from the plurality of chemical liquid flow passages flows; a nozzle body having an internal space; the nozzle body includes an outer jacket member, a tip side member attached to a tip end of the outer jacket member, and a gas injection part for filling the space with the gas; each of the plurality of chemical solution flow paths has a discharge pipe at a distal end thereof, the discharge pipe being a chemical solution discharge portion provided in the distal end member and discharging the chemical solution; an insertion hole through which the discharge pipe is inserted and held is formed at the tip end of the outer jacket member; the discharge pipe has a peripheral wall that defines the discharge direction of the chemical solution, the gas flow passage is a flow path between an inner wall surface of the insertion hole and the peripheral wall of the discharge pipe, the gas flow passage has a gas ejection portion at a tip end thereof that ejects gas toward the chemical solution ejected from the ejection pipe and sprays and mixes the chemical solution in the form of mist; a tip of the peripheral wall protrudes beyond a tip of the gas ejection portion, the space in the nozzle body is provided proximal to the insertion hole and has a flow path cross-sectional area larger than the flow path cross-sectional area of the gas flow path, and a distal end of the space is inclined so as to move away from the drug solution flow path as it moves proximally, the discharge pipe has a notch formed therein, the notch extending from the tip of the peripheral wall to the space in the nozzle body; The tissue adhesive applicator is characterized in that the notch is disposed so as to face the gas ejection portion.

2. a plurality of chemical solution flow paths through which the chemical solution flows; a gas flow passage through which a gas for mixing the chemical liquids discharged from the plurality of chemical liquid flow passages flows; a nozzle body having an internal space; each of the plurality of chemical liquid flow paths has a chemical liquid discharge portion at a tip end thereof for discharging a chemical liquid; the gas flow passage has a gas ejection part at a tip end thereof that ejects gas into the chemical solution discharged from the chemical solution ejection part to spray and mix the chemical solution in a mist form; the nozzle body has a gas injection portion for filling the space with the gas, the plurality of chemical liquid flow paths pass through the space inside the nozzle body, the space is connected to the gas flow passage, at least one of the drug solution flow paths is provided with an expansion / contraction section that contracts due to external pressure caused by the gas being introduced into the space from the gas injector and restores its original shape when the external pressure decreases, The expansion / contraction portion has a recess formed in a non-circular shape that extends longer in the circumferential direction than in the axial direction, and the non-recessed portion is continuous in the axial direction.

3. 3. The tissue adhesive applicator according to claim 2, wherein the recessed portion is formed to be thinner than the portion where the recessed portion is not formed.

4. 4. The tissue adhesive applicator according to claim 2, wherein the recesses are formed in a wave shape so as to be alternately curved and offset in the axial direction of the expansion / contraction section.

5. the gas ejection portion is a space around the chemical solution ejection portion, the chemical solution discharge portion has a peripheral wall that defines a discharge direction of the chemical solution, A notch is formed in the peripheral wall until it reaches the tip of the peripheral wall, 5. The tool for applying biological tissue adhesive according to claim 2, wherein the notch is disposed so as to face the gas ejection portion.

6. 6. The tissue adhesive applicator according to claim 5, wherein the notch extends from the tip of the peripheral wall to the inside of the gas flow passage.

7. 7. The tissue adhesive applicator according to claim 1, wherein the notch is formed obliquely with respect to the axial direction of the drug solution discharge portion.

8. 7. The tissue adhesive applicator according to claim 1, wherein the notch is a slit extending in the axial direction of the drug solution discharge portion.

9. The chemical solution flow passages are provided in pairs, the notches are formed in the respective chemical solution discharge portions provided in the pair of chemical solution flow paths, 9. The tissue adhesive applicator according to claim 1, wherein the notches formed in the pair of liquid medicine discharge portions are formed symmetrically with respect to an intermediate plane of the pair of liquid medicine discharge portions.

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