Thrombolysis promotion module and interventional thrombus removal device

Abstract

A thrombolysis promotion module and an interventional thrombus removal device are provided, the thrombolysis promotion module including a driving module and a cavitation module, the driving module being an ultrasonic module for generating acoustic energy, configured to generate ultrasonic waves having a first frequency for permeating microbubble precursors into a thrombus in a circumferential direction, the cavitation module being an ultrasonic module for generating acoustic energy, configured to generate ultrasonic waves having a second frequency greater than the first frequency in a circumferential direction, the ultrasonic waves having the second frequency causing cavitation in the microbubble precursors permeated into the thrombus or on its surface to form microbubbles, the thrombolysis promotion module of the present application can cause the microbubble precursors and the thrombus removal drug to permeate into the thrombus, and also causes cavitation in the microbubble precursors permeated into the thrombus or on its surface to form microbubbles, thereby increasing the contact area between the thrombus removal drug and the thrombus, and promoting the dissolution of the thrombus.

Description

[Technical Field]

[0001] The present invention relates to the technical field of medical devices, and in particular to a thrombolysis promotion module and an interventional thrombectomy device. [Background technology]

[0002] Cardiovascular and cerebrovascular embolism is one of the major diseases that threaten human life and health, and deep vein thrombosis (DVT) has a significant impact on patients' health and quality of life. Currently, commonly used clinical thrombus treatment methods include drug-induced thrombolysis, vascular stents, mechanical rotary ablation, and ultrasound-induced thrombolysis. However, these methods all have some drawbacks, such as drug-induced thrombolysis being prone to complications such as bleeding, and mechanical rotary ablation being prone to vascular damage. Therefore, a safer and more efficient interventional thrombectomy device is needed. Summary of the Invention [Problem to be solved by the invention]

[0003] To solve the problems pointed out in the background art above, embodiments of the present application provide a thrombolysis promotion module and an interventional thrombectomy device. [Means for solving the problem]

[0004] According to a first embodiment of the present application, there is provided a thrombolysis promotion module including: an ultrasonic module for generating acoustic energy, the drive module configured to generate ultrasonic waves having a first frequency in a circumferential direction for infiltrating microbubble precursors into a thrombus; and an ultrasonic module for generating acoustic energy, the cavitation module configured to generate ultrasonic waves having a second frequency greater than the first frequency in a circumferential direction for causing cavitation in the microbubble precursors that have infiltrated into the thrombus or on their surfaces to form microbubbles.

[0005] According to a second embodiment of the present application, there is provided another thrombolysis promotion module including: an ultrasonic module for generating acoustic energy, the driving module including one or more first piezoelectric elements; and an ultrasonic module for generating acoustic energy, the cavitation module including one or more second piezoelectric elements insulated from the first piezoelectric elements, wherein the driving module is configured to generate ultrasonic waves having a first frequency in the circumferential direction, and the cavitation module is configured to generate ultrasonic waves in the circumferential direction having a second frequency greater than the first frequency.

[0006] According to a third embodiment of the present application, there is provided an interventional thrombus removal device including at least one thrombolysis promotion module according to the above-mentioned embodiments, and a main pipe defining a lumen and including a distal portion that houses the thrombolysis promotion module, the distal portion being configured to release microbubble precursors within the lumen to the outside of the main pipe.

[0007] According to the embodiments of the present application, the installation of a driving module for generating a first energy allows the microbubble precursors and the thrombus-removing drug to penetrate into the thrombus, expanding the area of action of the thrombus-removing drug on the thrombus and promoting thrombus dissolution. In addition, the installation of a cavitation module for generating a second energy causes cavitation on the microbubble precursors that have penetrated into the thrombus or on the surface of the microbubble precursors to form microbubbles. The microbubbles loosen the structure of the thrombus and increase the contact area between the thrombus-removing drug and the thrombus, further promoting thrombus dissolution, effectively improving the efficiency of thrombus removal and achieving the beneficial effects of safety and efficiency. [Brief explanation of the drawings]

[0008] The drawings included are for the purpose of providing a better understanding of the embodiments of the present application, constitute a part of the specification, illustrate the embodiments of the present application, and together with the described contents, explain the principles of the present application. The drawings described below are only some examples of the present application, and it is obvious that a person skilled in the art can derive other drawings from these drawings without requiring creative work. [Figure 1] FIG. 1 shows one embodiment of a thrombolysis promotion module according to an embodiment of the present application. [Figure 2] FIG. 2 is a cross-sectional view of an example taken along line AA in FIG. [Figure 3] FIG. 2 is a cross-sectional view of an example taken along line BB in FIG. [Figure 4] FIG. 2 is a cross-sectional view of another example taken along the line AA in FIG. [Figure 5] 1. FIG. 4 is a cross-sectional view of another example taken along the line BB in FIG. [Figure 6] FIG. 10 is a diagram showing another embodiment of the thrombolysis promotion module according to the present invention. [Figure 7] FIG. 7 is a cross-sectional view of an example taken along line CC in FIG. 6. [Figure 8] FIG. 7 is a cross-sectional view of an example taken along line DD in FIG. 6. [Figure 9] FIG. 1 is a diagram showing the operating principle of the thrombolysis promotion module in the driving stage of an embodiment of the present application. [Figure 10] FIG. 1 is a diagram showing the working principle of the thrombolysis promotion module of an embodiment of the present application at the cavitation stage. [Figure 11] 1 is a flowchart showing the operation of the thrombolysis promotion module of an embodiment of the present application. [Figure 12] 1 is a diagram showing an example of an interventional thrombectomy device according to an embodiment of the present application. [Figure 13] 10A and 10B are diagrams showing another example of an interventional thrombectomy device according to an embodiment of the present application. DETAILED DESCRIPTION OF THE INVENTION

[0009] In order to clarify the purpose, technical solution and advantages of the embodiments of the present application, the embodiments of the present application will be described in more detail below in conjunction with the drawings, where the exemplary embodiments and the description thereof are for the purpose of interpreting the present application, rather than for limiting the present application.

[0010] In the embodiments of the present application, the terms "first," "second," etc. are used to distinguish between different terms and do not represent the spatial arrangement or chronological order of these elements, and these elements are not limited to such terms. The term "and / or" includes any and all combinations of one or more of the terms associated with it. The terms "comprise," "contain," "have," etc. refer to the presence of stated features, elements, elements, or components, but do not exclude the presence or addition of one or more other features, elements, elements, or components.

[0011] In the embodiments of the present application, the singular terms "one," "the," etc. can include the plural, and are not limited to the meaning of "one," but should be broadly understood to mean "one type" or "one class." The term "said" should be understood to include the plural as well as the singular, unless otherwise expressly indicated. The term "according to" should be understood to mean "according at least in part to" unless otherwise expressly indicated, and the term "based on" should be understood to mean "based at least in part on" unless otherwise expressly indicated. The term "plurality" means two or more than two, unless otherwise expressly indicated.

[0012] Hereinafter, embodiments of the present invention will be described with reference to the drawings.

[0013] According to one embodiment of the present application, a thrombolysis enhancing module 10 is provided.

[0014] FIG. 1 is a diagram showing one embodiment of a thrombolysis promotion module 10 according to the present invention, and FIG. 6 is a diagram showing another embodiment of a thrombolysis promotion module 10 according to the present invention.

[0015] As shown in Figures 1 and 6, the thrombolysis promotion module 10 of an embodiment of the present application is used for interventional thrombus removal and includes a driving module 101 and a cavitation module 102. The driving module 101 is configured to generate a first energy (see Figure 9) for causing microbubble precursors 100 to penetrate into a thrombus 200. Here, when performing interventional thrombus removal treatment, the microbubble precursors 100 are injected into a patient's blood vessel together with a thrombus removal drug, and the microbubble precursors 100 and the thrombus removal drug are mixed together. Under the action of the first energy, the microbubble precursors 100 and the thrombus removal drug (not shown) are caused to penetrate into the thrombus 200 together, thereby increasing the range of action of the thrombus removal drug on the thrombus 200 and promoting the dissolution of the thrombus. The cavitation module 102 is configured to generate a second energy (see FIG. 10 ) that causes cavitation on the microbubble precursor 100 or its surface that has penetrated the thrombus 200, forming microbubbles 300. Here, the second energy is different from the first energy, and the microbubble precursor 100 absorbs the second energy to generate a partial cavitation effect to form microbubbles 300. The microbubbles 300 loosen the structure of the thrombus 200, increasing the contact area between the thrombus removal drug and the thrombus 200, further promoting thrombus dissolution and improving thrombus removal efficiency.

[0016] When using the thrombolysis promotion module 10 according to the present embodiment, as shown in FIG. 11 , the driving module 101 is first activated to infiltrate the microbubble precursor 100 and the thrombus-removing drug into the thrombus 200 (this step can be referred to as the driving step). After the driving step reaches a predetermined time t1, the cavitation module 102 is activated to cavitate the microbubble precursor 100 infiltrated into the thrombus 200 to form microbubbles 300 (this step can be referred to as the cavitation step). When the cavitation step reaches a predetermined time t2, one thrombolysis process is completed. To enhance the thrombolysis effect, the thrombolysis process can be performed multiple times, i.e., the driving step and the cavitation step can be alternately performed multiple times. In some embodiments, at least one of the driving module 101 and the cavitation module 102 can be configured as an ultrasonic module for generating acoustic energy. The first energy and / or the second energy are acoustic energy. Using acoustic energy as energy is safe and efficient.

[0017] However, the present application is not limited thereto, and in other embodiments, at least one of the driving module 101 and the cavitation module 102 may be configured as a heat generating element for generating thermal energy, or as a light emitting element for generating light energy, i.e., the first energy and / or the second energy may be thermal energy or light energy.

[0018] In some embodiments, both the drive module 101 and the cavitation module 102 can be configured as ultrasonic modules for generating acoustic energy, where the first energy is ultrasonic waves having a first frequency and the second energy is ultrasonic waves having a second frequency, the second frequency being different from the first frequency.

[0019] Preferably, the second frequency is greater than the first frequency, i.e., low-frequency ultrasound is used as the first energy to cause the microbubble precursors 100 to penetrate the thrombus 200, and high-frequency ultrasound is used as the second energy to cavitate the microbubble precursors 100 that have penetrated the thrombus 200, thereby forming microbubbles 300.

[0020] In some embodiments, the microbubble precursors 100 are micro-nano droplets, and the micro-nano droplets can be cavitated into microbubbles, and correspondingly, the first frequency can be between 20 kHz and 1 MHz, and the second frequency can be between 1 MHz and 20 MHz.

[0021] For example, the micro-nano droplets can be fluorocarbon compound droplets, and the diameter of the droplets can be 100 nm to 800 nm.

[0022] In another embodiment, the microbubble precursor 100 can be a micro-nanoparticle, and the gas nuclei at the interface between the micro-nanoparticle and the solution can be cavitated into microbubbles, and correspondingly, the first frequency can be 20 kHz to 1 MHz, and the second frequency can be 1 MHz to 20 MHz.

[0023] For example, the micro-nanoparticles can be porous nanospheres with particle diameters of 10 nm to 500 nm.

[0024] In addition to the above-mentioned embodiments, the microbubble precursor 100 can also be a mixture of micro- or nano-droplets and micro- or nano-particles. Those skilled in the art can select the shape, composition and size of the microbubble precursor 100 according to their needs, and determine the corresponding first and second frequencies. All such modifications, alterations and equivalent technical solutions are within the scope of protection of the present application.

[0025] In some embodiments, as shown in Figures 1 and 6, the driving module 101 includes one or more first piezoelectric elements 103, and the cavitation module 102 includes one or more second piezoelectric elements 104, and the first piezoelectric elements 103 and the second piezoelectric elements 104 are insulated from each other, so that the first piezoelectric elements 103 and the second piezoelectric elements 104 generate ultrasonic waves independently and do not interfere with each other.

[0026] In order to provide an excitation signal to the first piezoelectric element 103 and the second piezoelectric element 104, an anode and a cathode can be provided to sandwich the first piezoelectric element 103, and an anode and a cathode can be provided to sandwich the second piezoelectric element 104.

[0027] The material of the first piezoelectric element 103 and the second piezoelectric element 104 can be a piezoelectric material, for example, a lead zirconate titanate material. The material of the electrodes can be a conductive material, for example, a silver or copper material.

[0028] 1 and 6, the drive module 101 includes a plurality of first piezoelectric elements 103, which are spaced apart along the axial direction and insulated from one another, and the cavitation module 102 includes a plurality of second piezoelectric elements 104, which are spaced apart along the axial direction and insulated from one another.

[0029] In this embodiment, the plurality of first piezoelectric elements 103 and the plurality of second piezoelectric elements 104 are arranged at intervals along the axial direction, thereby generating ultrasound waves at different positions along the axial direction, thereby widening the energy action range and further improving the efficiency of thrombus removal. In another embodiment, only some of the piezoelectric elements can be activated to generate ultrasound waves only at specific positions according to actual needs, thereby further improving the flexibility and convenience of use.

[0030] In the example of Figure 1, multiple first piezoelectric elements 103 and multiple second piezoelectric elements 104 are arranged alternately along the axial direction, and adjacent first piezoelectric elements 103 and second piezoelectric elements 104 are separated and insulated by insulating elements.

[0031] Here, the first piezoelectric element 103 and the second piezoelectric element 104 can be configured in a variety of different structures.

[0032] For example, in a possible technical solution, as shown in Figures 2 and 3, the first piezoelectric elements 103 and the second piezoelectric elements 104 can be arranged alternately on the same axis in an annular structure, for example, a circular annular structure, capable of generating ultrasonic waves in the entire circumferential direction, and the first piezoelectric elements 103 and the second piezoelectric elements 104 are isolated by an insulating element 105 (see Figure 1). In this structure, when installing electrodes, a thin first electrode 106 extending continuously along the axial direction is installed in the central hole of the first piezoelectric element 103 and the second piezoelectric element 104, and a second electrode 107 extending continuously along the axial direction is installed on the outer periphery of the first piezoelectric element 103 and the second piezoelectric element 104, so that excitation signals can be provided to all of the first piezoelectric elements 103 and the second piezoelectric elements 104, where the polarities of the second electrode and the first electrode are opposite, resulting in a simple structure. However, this embodiment is not limited to this, and the first electrode 106 and the second electrode 107 may be configured as a plurality of individual electrodes arranged along the axial direction.

[0033] Furthermore, in another possible technical solution, for example, as shown in Figures 4 and 5, the first piezoelectric element 103 and the second piezoelectric element 104 can be in a rectangular sheet structure or other sheet structure, and the first piezoelectric element 103 and the second piezoelectric element 104 can be alternately arranged along the axial direction to form a layered piezoelectric component. For example, two layers of piezoelectric components can be installed, and a first electrode 106 extending continuously along the axial direction can be installed between the two layers of piezoelectric components. That is, the first electrode 106 can be used for the two layers of piezoelectric components, and two second electrodes 107 extending continuously along the axial direction can be installed on the outside of the two layers of piezoelectric components, respectively. The second electrode 107 and the first electrode 106 have opposite polarities, and one of the second electrodes 107 sandwiches one layer of piezoelectric components together with the first electrode 106, and the other second electrode 107 sandwiches the other layer of piezoelectric components together with the first electrode 106. However, this embodiment is not limited to this, and the first electrode 106 and the second electrode 107 may be configured by arranging a plurality of individual electrodes along the axial direction.

[0034] In the example of Figure 6, multiple first piezoelectric elements 103 and multiple second piezoelectric elements 104 are arranged parallel to each other in the diameter direction, and adjacent first piezoelectric elements 103 and adjacent second piezoelectric elements 104 are separated by insulating elements to achieve insulation.

[0035] Here, the first piezoelectric element 103 and the second piezoelectric element 104 can be a rectangular sheet structure or other sheet structure, and a plurality of first piezoelectric elements 103 are arranged in sequence at intervals along the axial direction to form a first piezoelectric component of one layer (see Figures 6 and 7), and adjacent first piezoelectric elements 103 are isolated by insulating elements 108 (see Figure 6), and a plurality of second piezoelectric elements 104 are arranged in sequence at intervals along the axial direction to form a second piezoelectric component of one layer (see Figures 6 and 8), and adjacent second piezoelectric elements 104 are isolated by insulating elements 109 (see Figure 6), and the first piezoelectric element 103 and the second piezoelectric element 104 are spaced apart in the diametric direction, and preferably, the first piezoelectric element 103 and the second piezoelectric element 104 are The first and second piezoelectric elements 103 and 104 are offset from each other in the axial direction (see FIG. 6 ) to reduce the influence between them. When installing the electrodes, a first electrode 110 extending continuously along the axial direction can be installed between the first and second piezoelectric elements. That is, the first electrode 110 is used for both the first and second piezoelectric elements. Two second electrodes 111 extending continuously along the axial direction can be installed on the outside of the first and second piezoelectric elements, respectively. The polarities of the second electrode 111 and the first electrode 110 are opposite. Here, one second electrode 111 sandwiches the first piezoelectric element together with the first electrode 110, and the other second electrode 111 sandwiches the second piezoelectric element together with the first electrode 110. However, this embodiment is not limited thereto. The first electrode 110 and the second electrode 111 can also be configured as a plurality of individual electrodes arranged along the axial direction.

[0036] In some embodiments, as shown in Figures 1 and 6, the thrombolysis promotion module 10 further includes an insulating cover 112, and the driving module 101 and the cavitation module 102 are installed inside the insulating cover 112, and the insulating cover 112 isolates the driving module 101 and the cavitation module 102 from the outside to achieve insulation.

[0037] In some embodiments, as shown in Figures 12 and 13, the thrombolysis promotion module 10 further includes a control module 113, which is electrically connected to the driving module 101 and the cavitation module 102, and provides excitation signals and inputs energy to the driving module 101 and the cavitation module 102.

[0038] Specifically, the control module 113 is electrically connected to the electrodes of the drive module 101 and the cavitation module 102 .

[0039] According to another embodiment of the present application, an interventional thrombus removal device is provided, which includes at least one thrombolysis promotion module 10 as described in the first embodiment, as shown in Figures 12 and 13. The structure of the thrombolysis promotion module 10 has been described in detail in the first embodiment, and the content thereof may be incorporated herein, so further description will be omitted.

[0040] As shown in Figures 12 and 13, the interventional thrombus removal device further includes a main pipe 20, which defines a lumen 21 and includes a distal portion 22 that houses the thrombolysis promotion module 10. When performing interventional thrombus removal treatment on a patient, the distal portion 22 is delivered to the thrombus site in the blood vessel, and is configured to release the microbubble precursors 100 in the lumen 21 out of the main pipe 20 so that the microbubble precursors 100 and the thrombus removal drug can act on the thrombus 200 (see Figures 9 and 10).

[0041] In some embodiments, the interventional thrombectomy device may have multiple thrombolysis promotion modules 10, and the multiple thrombolysis promotion modules 10 may be spaced apart along the axial direction of the main pipe 20.

[0042] In some embodiments, as shown in Figures 12 and 13, distal portion 22 has through-holes 221 formed in its side wall for releasing microbubble precursors 100. In the examples of Figures 12 and 13, distal portion 22 has multiple rows of through-holes formed in its side wall, spaced apart along the circumferential direction, and the multiple through-holes 221 in each row are spaced apart along the axial direction, allowing microbubble precursors 100 and clot removal drugs to be released at multiple different positions in the circumferential and axial directions.

[0043] For example, the distance between adjacent through holes 221 in the axial direction is 0.5 mm to 5 mm, and the diameter of the through holes is 1 mm to 3 mm.

[0044] 12 and 13 , the interventional thrombectomy device further includes a protective pipe 30 penetrating through the lumen 21, which divides the lumen 21 into an inner central cavity 211 and an outer surrounding cavity 212, i.e., the surrounding cavity 212 surrounds the central cavity 211, the thrombolysis promotion module 10 is located within the central cavity 211, and the surrounding cavity 212 is connected to the through-hole 221. The surrounding cavity 212 is used to inject the microbubble precursors 100 and the thrombus-removing drug, for example, by using a syringe 400 to inject the microbubble precursors 100 and the thrombus-removing drug into the surrounding cavity 212. Here, the protective pipe 30 is an insulating pipe.

[0045] Although the present application has been described by combining specific embodiments, those skilled in the art will understand that these descriptions are merely illustrative and do not limit the scope of protection of the present application. Those skilled in the art can make various modifications and alterations to the present application based on the spirit and principles of the present application, and these modifications and alterations are also within the scope of the present application.

[0046] This application claims priority to a Chinese patent application filed on October 22, 2021, bearing application number 202111232878.4, and incorporates by reference the contents disclosed in the above patent application as part of this application.

Claims

1. A thrombolysis promotion module, an ultrasonic module for generating acoustic energy, the drive module configured to generate ultrasonic waves having a first frequency for infiltrating microbubble precursors into the thrombus in a circumferential direction; an ultrasound module for generating acoustic energy, the cavitation module being configured to generate ultrasound waves having a second frequency greater than the first frequency for causing cavitation in a circumferential direction on microbubble precursors or their surfaces that have infiltrated into the thrombus to form microbubbles; A thrombolysis promotion module characterized in that first, the driving module is operated, and the step of operating the driving module is a driving step, and after the driving step reaches one scheduled time, the cavitation module is operated, and the step of operating the cavitation module is a cavitation step, and when the cavitation step reaches another scheduled time, one thrombolysis process is completed.

2. The thrombolysis promotion module according to claim 1, characterized in that the microbubble precursors are micro-nano droplets, the first frequency is 20 kHz to 1 MHz, and the second frequency is 1 MHz to 20 MHz.

3. 3. The thrombolysis promotion module according to claim 2, wherein the microbubble precursor is a fluorocarbon compound droplet.

4. The thrombolysis promotion module according to claim 1, characterized in that the microbubble precursors are micro-nanoparticles, the first frequency is 20 kHz to 1 MHz, and the second frequency is 1 MHz to 20 MHz.

5. The thrombolysis promotion module according to claim 4, wherein the microbubble precursor is a porous nanosphere.

6. The thrombolysis promotion module of claim 1, characterized in that the drive module includes one or more first piezoelectric elements, the cavitation module includes one or more second piezoelectric elements, and the first piezoelectric elements and the second piezoelectric elements are insulated from each other.

7. The thrombolysis promotion module according to claim 6, wherein the plurality of first piezoelectric elements are spaced apart along the axial direction and insulated from one another, and the plurality of second piezoelectric elements are spaced apart along the axial direction and insulated from one another.

8. 8. The thrombolysis promoting module according to claim 6, wherein the plurality of first piezoelectric elements and the plurality of second piezoelectric elements are arranged alternately along the axial direction.

9. 8. The thrombolysis promotion module according to claim 6, wherein the plurality of first piezoelectric elements and the plurality of second piezoelectric elements are arranged in parallel in the diameter direction.

10. 8. The thrombolysis promoting module according to claim 6, wherein the first piezoelectric element and the second piezoelectric element are coaxially arranged along the axial direction.

11. 8. The thrombolysis promoting module according to claim 6, wherein the first piezoelectric element and the second piezoelectric element are arranged so as to be offset from each other in the axial direction.

12. The thrombolysis promotion module according to any one of claims 1 to 6, further comprising an insulating cover in which the driving module and the cavitation module are disposed.

13. The thrombolysis promotion module of any one of claims 1 to 6, further comprising a control module electrically connected to the driving module and the cavitation module to provide excitation signals to the driving module and the cavitation module and input energy.

14. 7. The thrombolysis promotion module according to claim 1, which is an interventional thrombolysis promotion module.

15. 7. The thrombolysis promotion module according to claim 1, wherein the microbubble precursor is permeated from blood into a thrombus.

16. The thrombolysis promotion module according to any one of claims 1 to 6, wherein the driving step and the cavitation step are performed alternately.

17. A thrombolysis promotion module, an ultrasonic module for generating acoustic energy, the drive module including one or more first piezoelectric elements; an ultrasonic module for generating acoustic energy, the cavitation module including one or more second piezoelectric elements insulated from the first piezoelectric element; the drive module is configured to generate ultrasonic waves having a first frequency in a circumferential direction, and the cavitation module is configured to generate ultrasonic waves having a second frequency in the circumferential direction that is greater than the first frequency; A thrombolysis promotion module characterized in that first, the driving module is operated, and the step of operating the driving module is a driving step, and after the driving step reaches one scheduled time, the cavitation module is operated, and the step of operating the cavitation module is a cavitation step, and when the cavitation step reaches another scheduled time, one thrombolysis process is completed.

18. 18. The thrombolysis promotion module according to claim 17, wherein the first frequency is 20 kHz to 1 MHz, and the second frequency is 1 MHz to 20 MHz.

19. The thrombolysis promotion module according to claim 17, wherein the plurality of first piezoelectric elements are spaced apart along the axial direction and insulated from one another, and the plurality of second piezoelectric elements are spaced apart along the axial direction and insulated from one another.

20. 20. The thrombolysis promotion module according to claim 17, wherein the plurality of first piezoelectric elements and the plurality of second piezoelectric elements are arranged alternately along the axial direction.

21. 20. The thrombolysis promotion module according to any one of claims 17 to 19, wherein the plurality of first piezoelectric elements and the plurality of second piezoelectric elements are arranged in parallel in the diameter direction.

22. 20. The thrombolysis promotion module according to claim 17, wherein the first piezoelectric element and the second piezoelectric element are arranged coaxially along the axial direction.

23. 20. The thrombolysis promoting module according to claim 17, wherein the first piezoelectric element and the second piezoelectric element are arranged so as to be offset from each other in the axial direction.

24. The thrombolysis promotion module according to any one of claims 17 to 19, further comprising an insulating cover in which the driving module and the cavitation module are disposed.

25. The thrombolysis promotion module of any one of claims 17 to 19, further comprising a control module electrically connected to the driving module and the cavitation module, for providing excitation signals to the driving module and the cavitation module and inputting energy thereto.

26. 20. The thrombolysis promotion module according to any one of claims 17 to 19, which is an interventional thrombolysis promotion module.

27. The thrombolysis promotion module according to any one of claims 17 to 19, wherein the driving step and the cavitation step are performed alternately.

28. 1. An interventional thrombectomy device comprising: At least one thrombolysis promotion module according to any one of claims 1 to 6 and 17 to 19; a main pipe defining a lumen and including a distal portion housing the thrombolysis promotion module, the distal portion configured to release microbubble precursors within the lumen to an exterior of the main pipe; 1. An interventional thrombectomy device comprising:

29. 29. The interventional thrombectomy device of claim 28, wherein the side wall of the distal portion is formed with through-holes for releasing the microbubble precursors.

30. The interventional thrombus removal device of claim 29, further comprising a protective pipe penetrating the lumen, the protective pipe dividing the lumen into a central cavity and an surrounding cavity surrounding the central cavity, the thrombolysis promotion module being provided within the central cavity, and the surrounding cavity being connected to the through hole.

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