Blood purification device

Abstract

To provide a blood purification device capable of using a B agent stock solution used in a blood purification therapy step, as an alkali agent used in a fat removing cleaning step, as well as, capable of removing carbon dioxide generated in the fat removing cleaning step, for preferably performing the fat removing cleaning.SOLUTION: A blood purification device comprises: a piping part having a dialysate introduction line L1 and a drainage discharge line L2; a dual pump 1; and a control part 13 which performs a blood purification therapy step of feeding, to a dialyzer C, a dialysate obtained by introducing an A agent stock solution and a B agent stock solution to the piping part and mixing them, and then diluting the mixture to prescribed concentration, and a fat removing cleaning step of removing fat on the piping part through circulation of a sodium carbonate aqueous solution obtained by introducing, to the piping part, and heating the B agent stock solution, The control part 13, while executing the fat removing cleaning step, discharges, out of the piping part, carbon dioxide which is generated when circulating the sodium carbonate aqueous solution.SELECTED DRAWING: Figure 4

Description

[Technical Field]

[0001] The present invention relates to a blood purification device that purifies a patient's blood by extracorporeally circulating the patient's blood through a blood circuit. [Background technology]

[0002] A dialysis machine, which is a blood purification device used in dialysis treatment and the like, usually has a piping section with a dialysate inlet line for introducing dialysate into the blood purifier and a drainage drain line for discharging drainage from the blood purifier, and a fluid delivery section for delivering the dialysate and drainage in the piping section. The dialysis machine is configured by connecting a blood circuit for circulating the patient's blood extracorporeally to the blood purifier, and performs dialysis treatment (blood purification treatment) using the blood purifier while circulating the patient's blood extracorporeally through the blood circuit.

[0003] Such blood purification devices are typically kept hygienic over a long period of time by periodically carrying out a degreasing step in which an alkaline agent, such as sodium carbonate or sodium hypochlorite, is introduced into and circulated through the flow paths of the piping to perform degreasing and cleaning. Conventionally, it has been proposed to generate an aqueous sodium carbonate solution by heating an agent B stock solution used to prepare dialysis fluid, and to use this resulting aqueous sodium carbonate solution as the alkaline agent circulated through the piping in the degreasing step (see, for example, Patent Document 1).

[0004] In this way, by heating the stock solution of Agent B used to prepare dialysis fluid in dialysis treatment and using the resulting sodium carbonate aqueous solution as an alkaline agent to be circulated in the degreasing process, it is possible to reuse the stock solution of Agent B remaining in dialysis treatment, thereby reducing the cost of using chemicals and the number of types of chemicals used in the degreasing process, thereby reducing the effort required for management. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 2018-118033 Summary of the Invention [Problem to be solved by the invention]

[0006] However, in the above-mentioned conventional blood purification device, although the stock solution of Agent B used in dialysis treatment (blood purification treatment process) can be reused as the alkaline agent (sodium carbonate aqueous solution) used in the degreasing and cleaning process, it is expected that carbon dioxide (CO2) generated when the stock solution of Agent B is heated will remain in the piping, and there is a risk that the degreasing and cleaning will not be performed well. Also, it is possible to remove the carbon dioxide generated when the stock solution of Agent B is heated by degassing in advance, but even in that case, there is a risk that the carbon dioxide generated during the degreasing and cleaning process will remain in the piping.

[0007] The present invention has been made in consideration of the above circumstances, and aims to provide a blood purification device that can reuse the stock solution of agent B used in the blood purification treatment process as the alkaline agent used in the degreasing and cleaning process, and can remove carbon dioxide generated during the degreasing and cleaning process, thereby enabling good degreasing and cleaning. [Means for solving the problem]

[0008] A blood purification apparatus according to one embodiment of the present invention is a blood purification apparatus that circulates a patient's blood extracorporeally through a blood purifier and a blood circuit to purify the blood, and is equipped with a piping section having a dialysate introduction line for introducing dialysate into the blood purifier and a effluent discharge line for discharging effluent from the blood purifier, a fluid delivery section for delivering liquid through the piping section, and a control section that controls the fluid delivery section to perform a blood purification treatment step in which an A agent stock solution and a B agent stock solution are introduced into the piping section, mixed, and diluted to a predetermined concentration to prepare a dialysis solution, and the dialysis solution is delivered to the blood purifier, and a degreasing and washing step in which an aqueous bicarbonate solution obtained by introducing and heating the B agent stock solution into the piping section is circulated to remove grease from the piping section, and the control section discharges carbon dioxide generated when the aqueous bicarbonate solution is circulated to the outside of the piping section while performing the degreasing and washing step. and the blood purification treatment device has a bubble filter that captures bubbles contained in the dialysis fluid, a primary side section upstream of the bubble filter in which the bubbles captured by the bubble filter are accommodated, and a secondary side section downstream of the bubble filter through which the dialysis fluid that has passed through the bubble filter flows, and a capture unit that captures bubbles contained in the dialysis fluid while passing the dialysis fluid during the blood purification treatment step is connected to the dialysis fluid introduction line, and the bubble filter of the capture unit captures carbon dioxide when a bicarbonate aqueous solution is passed through during the degreasing and cleaning step. It is something. [Effects of the Invention]

[0009] According to the present invention, while the degreasing and cleaning process is being carried out, the carbon dioxide generated when the bicarbonate aqueous solution is circulated is discharged to the outside of the piping section, so that the B agent concentrate used in the blood purification treatment process can be reused as the alkaline agent used in the degreasing and cleaning process, and the carbon dioxide generated during the degreasing and cleaning process can be removed to ensure good degreasing and cleaning. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a schematic diagram showing a blood purification device according to an embodiment of the present invention; [Figure 2] FIG. 1 is a schematic diagram illustrating the blood purification treatment process performed by the blood purification device. [Figure 3] FIG. 1 is a schematic diagram illustrating the bicarbonate aqueous solution production process performed in the blood purification device. [Figure 4] Schematic diagram for explaining the degreasing and washing process performed in the blood purification device. [Figure 5] FIG. 1 is a schematic diagram illustrating a process of discharging carbon dioxide during a degreasing and cleaning process performed in the blood purification device. [Figure 6] A flowchart showing the control by the control unit of the blood purification device. DETAILED DESCRIPTION OF THE INVENTION

[0011] Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings. The blood purification device of this embodiment purifies a patient's blood by circulating it extracorporeally through a blood purifier and a blood circuit. As shown in FIG. 1, the device is configured to include a blood circuit K having an arterial blood circuit K1 and a venous blood circuit K2, a dialyzer C as a blood purifier, a piping section having a dialysate inlet line L1 and a dialysis fluid outlet line L2, a duplex pump 1 as a fluid delivery section, and a control section 13.

[0012] The arterial blood circuit K1 has a connector connected to its tip, through which an arterial puncture needle can be connected, and a peristaltic blood pump and an arterial air trap chamber are disposed midway. On the other hand, the venous blood circuit K2 has a connector connected to its tip, through which a venous puncture needle can be connected, and a venous air trap chamber is disposed midway.

[0013] The dialyzer C (blood purifier) ​​has a housing formed with a blood inlet C1 (blood inlet port), a blood outlet C2 (blood outlet port), a dialysate inlet C3 (dialysate flow path inlet: dialysate inlet port), and a dialysate outlet C4 (dialysate flow path outlet: dialysate outlet port), of which the blood inlet C1 is connected to an arterial blood circuit K1 and the blood outlet C2 is connected to a venous blood circuit K2. The dialysate inlet C3 and the dialysate outlet C4 are connected to a dialysate introduction line L1 and a effluent discharge line L2, respectively.

[0014] Dialyzer C contains a plurality of hollow fiber membranes (not shown), which constitute a blood purification membrane for purifying blood. A blood flow path (a flow path between a blood inlet C1 and a blood outlet C2) through which the patient's blood flows via the blood purification membrane, and a dialysate flow path (a flow path between a dialysate inlet C3 and a dialysate outlet C4) through which the dialysate flows are formed within the dialyzer C. The hollow fiber membranes constituting the blood purification membranes have numerous minute pores formed through their outer and inner surfaces, allowing impurities in the blood to pass through the membranes into the dialysate.

[0015] When the blood pump is driven with the arterial puncture needle connected to the tip of the arterial blood circuit K1 and the venous puncture needle connected to the tip of the venous blood circuit K2 inserted into the patient, the patient's blood passes through the arterial blood circuit K1 to the dialyzer C, where it is subjected to blood purification treatment, and then returns to the patient's body through the venous blood circuit K2. In this way, the patient's blood can be purified by the dialyzer C while being circulated extracorporeally through the blood circuit K.

[0016] The main body of the device includes a piping section including a dialysate inlet line L1 for introducing dialysate into the dialyzer C and a effluent discharge line L2 for discharging effluent from the dialyzer C, and a duplex pump 1 (fluid delivery section) for delivering the dialysate and effluent through the piping section. The duplex pump 1 has an intake section 1a connected to the dialysate inlet line L1 and an outlet section 1b connected to the effluent discharge line L2, and is a pump disposed across the dialysate inlet line L1 and the effluent discharge line L2. When the duplex pump 1 is driven, the dialysate is introduced from the dialysate inlet line L1 to the dialyzer C, and the dialysate introduced into the dialyzer C is discharged from the effluent discharge line L2 together with waste products and excess water in the blood. Note that other means than the duplex pump 1 (for example, a so-called balancing chamber) may be used.

[0017] As shown in FIG. 1, the piping section includes, in addition to the dialysate inlet line L1 and the effluent discharge line L2, bypass lines L3 to L5 connected to the dialysate inlet line L1 and the effluent discharge line L2, a bypass line L6 that bypasses the discharge section 1b of the duplex pump 1 in the effluent discharge line L2, and an agent A concentrate inlet line L7 and an agent B concentrate inlet line L8 that connect an agent A concentrate storage tank T1 and an agent B concentrate storage tank T2 to the dialysate inlet line L1, respectively.

[0018] Solenoid valves (V5-V7) are connected to bypass lines L3-L5, respectively, and solenoid valves (V8, V9) are connected to agent A concentrate introduction line L7 and agent B concentrate introduction line L8, respectively. Infusion pumps (8a, 8b) are connected to agent A concentrate introduction line L7 and agent B concentrate introduction line L8, respectively. When solenoid valve V8 is in an open state, injection pump 8a is driven to introduce agent A concentrate in agent A concentrate storage tank T1 into dialysate introduction line L1 via agent A concentrate introduction line L7, and when solenoid valve V9 is in an open state, injection pump 8b is driven to introduce agent B concentrate in agent B concentrate storage tank T2 into dialysate introduction line L1 via agent B concentrate introduction line L8.

[0019] Furthermore, the dialysate inlet line L1 is connected to electromagnetic valves (V1, V3), a heat exchanger 3, a heating unit 4, a degassing pump 7, a degassing unit 5, a stirring chamber (9a, 9b), and a capture unit (10, 11). The heat exchanger 3 has a flow path through which purified water (RO water) supplied to the dialysate inlet line L1 flows, and a flow path through which effluent from the effluent discharge line L2 flows, and is configured to transfer heat from the effluent to the purified water by heat exchange between these flow paths.

[0020] The heating unit 4 is composed of a heater attached to the dialysate introduction line L1 and is capable of heating the purified water supplied to the dialysate introduction line L1. A temperature sensor t is attached downstream of the heating unit 4 (on the right side in FIG. 1 ) and is configured to be able to detect the temperature (water temperature) of the purified water heated by the heating unit 4. An orifice unit 6 is formed downstream of the temperature sensor t, and the purified water that passes through the orifice unit 6 is introduced into the degassing unit 5 by driving a degassing pump 7.

[0021] The degassing unit 5 is composed of a chamber connected to the dialysate introduction line L1, and a circulation line L9 (circulation flow path) extends from the bottom of the chamber. The circulation line L9 is connected to a predetermined position on the dialysate introduction line L1 upstream of the degassing unit 5 (a position between the heat exchanger 3 and the heating unit 4), and is configured to circulate the purified water supplied to the dialysate introduction line L1. A degassing line N1 extending to the effluent discharge line L2 is connected to the top of the degassing unit 5, and air bubbles collected in the degassing unit 5 can be discharged to the outside of the piping via the degassing line N1.

[0022] The agent A stock solution and the agent B stock solution are composed of solutions with different compositions that make up the dialysis fluid. Specifically, the agent A stock solution (agent A stock solution) is composed of a mixed aqueous solution containing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate, etc., and the agent B stock solution (agent B stock solution) is composed of an aqueous solution of sodium bicarbonate (NaHCO3). These agent A stock solutions and agent B stock solutions are stored in predetermined amounts in agent A stock solution storage tank T1 and agent B stock solution storage tank T2, respectively, and are introduced into the dialysis fluid introduction line L1 by driving injection pumps (8a, 8b).

[0023] The stirring chambers (9a, 9b) are capable of producing a dialysis solution of a predetermined concentration by mixing and diluting the agent A stock solution and agent B stock solution introduced into the dialysis solution introduction line L1 via the agent A stock solution introduction line L7 and the agent B stock solution introduction line L8 with purified water. That is, the purified water supplied to the dialysis solution introduction line L1 is heated by the heating unit 4 and degassed (air bubbles are removed) by the degassing unit 5 while circulating through the circulation line L9, and then mixed with the agent A stock solution and agent B stock solution to produce a dialysis solution of a predetermined concentration.

[0024] The trapping units (10, 11) trap air bubbles contained in the dialysis fluid while it is passing through the dialysis fluid during the blood purification treatment process, and each trapping unit (10, 11) has an air bubble filter (10a, 11a), a primary side section (10b, 11b) upstream of the air bubble filter (10a, 11a) in which the trapped air bubbles are accommodated, and a secondary side section (10c, 11c) downstream of the air bubble filter (10a, 11a) through which the permeated dialysis fluid flows. The primary side section 10b of the trapping unit 10 is connected to the effluent discharge line L2 by a bypass line L4, and the primary side section 11b of the trapping unit 11 is connected to the effluent discharge line L2 by a bypass line L5.

[0025] Furthermore, fluid pressure detection units (S1, S2) each consisting of a sensor capable of detecting fluid pressure are disposed downstream (or upstream) of the air bubble filters (10a, 11a) in the dialysate introduction line L1. When the fluid pressure detection units (S1, S2) detect a predetermined change in fluid pressure during the blood purification treatment process, the solenoid valves (V6, V7) (on-off valves) are opened to discharge bubbles in the primary side portions (10b, 11b) to the outside of the piping via the bypass lines (L4, L5) and the waste fluid discharge line L2.

[0026] On the other hand, solenoid valves (V2, V4), a pressure pump P, and a degassing chamber 12 are connected to the effluent discharge line L2, and a detouring pump 2 is connected to a bypass line L6 that bypasses the discharge section 1b of the duplex pump 1. The detouring pump 2 is used to remove water (excess water) from the patient's blood flowing through the dialyzer C. That is, when the detouring pump 2 is driven, the volume of the effluent discharged from the effluent discharge line L2 becomes greater than the volume of dialysate introduced from the dialysate inlet line L1, and water is removed from the blood by the amount of the larger volume.

[0027] The degassing chamber 12 is composed of a chamber connected to the waste liquid discharge line L2, and its lower part is connected to a predetermined position of the bypass line L6 by a connection line L6a. In addition, a degassing line N2 extending to the downstream part of the waste liquid discharge line L2 is connected to the upper part of the degassing chamber 12, and air bubbles collected in the degassing chamber 12 can be discharged to the outside of the piping via this degassing line N2. In addition, a solenoid valve V10 is connected to the degassing line N2 and can be opened and closed at any time.

[0028] The control unit 13 is composed of a microcomputer disposed in the device main body, and executes a blood purification treatment step in which the stock solutions of agents A and B are introduced into the piping unit, mixed, and diluted to a predetermined concentration to prepare a dialysis solution, which is then sent to the dialyzer C. That is, in the blood purification treatment step, as shown in Fig. 2, the solenoid valves (V8, V9) are opened, the infusion pumps (8a, 8b) are operated, and the duplex pump 1 and the water removal pump 2 are driven, so that the stock solutions of agents A and B introduced into the dialysis solution inlet line L1 are mixed with clean water to prepare a dialysis solution of a predetermined concentration, and the dialysis solution is sent to the dialyzer C to purify and remove water from the patient's blood, thereby performing dialysis treatment.

[0029] Here, in addition to the blood purification treatment process, the control unit 13 according to this embodiment can control the duplex pump 1 to perform the following processes: a bicarbonate aqueous solution production process in which a predetermined volume of bicarbonate aqueous solution is produced while carbon dioxide is discharged using the heating unit 4 and the degassing unit 5; and a degreasing and cleaning process in which the bicarbonate aqueous solution obtained by introducing and heating the agent B stock solution into the piping section is circulated to remove oil and grease from the piping section. The bicarbonate aqueous solution production process is a process in which the agent B stock solution used in the blood purification treatment process is used to produce an alkaline agent (sodium carbonate aqueous solution) to be used in the degreasing and cleaning process, and the degreasing and cleaning process is a process in which the alkaline agent produced in the bicarbonate aqueous solution production process is circulated through the piping section to perform degreasing and cleaning.

[0030] More specifically, in the bicarbonate aqueous solution generating step, as shown in Fig. 3, the tip of the dialysate inlet line L1 and the tip of the effluent discharge line L2 are connected and short-circuited by coupler D, the solenoid valves (V4, V5, V9) are opened and the other solenoid valves are closed, and the degassing pump 7 and the infusion pump 8b are driven. At this time, the duplex pump 1, the ultrafiltration pump 2, etc. are stopped. As a result, the agent B stock solution in the agent B stock solution storage tank T2 is introduced into the dialysate inlet line L1, and the agent B stock solution can be heated by the heating unit 4 while circulating through the circulation line L9.

[0031] The agent B stock solution (sodium bicarbonate (NaHCO3)) is circulated through circulation line L9 and diluted while being heated (heated to approximately 65°C or higher) in heating section 4, whereby it is decomposed into sodium carbonate (Na2CO3), water (H2O), and carbon dioxide (CO2). This allows an aqueous sodium carbonate solution (aqueous bicarbonate solution) to be produced from the agent B stock solution as an alkaline agent used in the degreasing and cleaning process. The carbon dioxide produced when the agent B stock solution is heated in heating section 4 is collected in degassing section 5 and is discharged to the outside of the piping section via degassing line N1 and waste liquid discharge line L2.

[0032] In the bicarbonate aqueous solution production process, the heating unit 4 heats the agent B stock solution introduced into the piping unit, and the degassing unit 5 can discharge to the outside of the piping unit the carbon dioxide produced when the agent B stock solution is heated in the heating unit 4. That is, in the process of circulating the agent B stock solution through the circulation line L9, the agent B stock solution can be heated in the heating unit 4 to produce an aqueous sodium carbonate solution (aqueous bicarbonate solution), while the degassing unit 5 can discharge carbon dioxide.

[0033] In this way, the heating unit 4 and the degassing unit 5 heat and degas purified water for preparing a dialysis solution of a predetermined concentration by circulating and mixing the agent A stock solution and the agent B stock solution through the circulation line L9 in the blood purification treatment step, and can heat the agent B stock solution to produce an aqueous sodium carbonate solution while discharging carbon dioxide in the aqueous bicarbonate solution production step. After the aqueous bicarbonate solution production step is performed by the heating unit 4 and the degassing unit 5 to produce a predetermined volume of aqueous sodium carbonate solution while discharging carbon dioxide, the degreasing and cleaning step is performed using the aqueous sodium carbonate solution.

[0034] Furthermore, in this embodiment, the device has a reservoir that stores a predetermined volume of aqueous sodium carbonate solution produced by heating the agent B stock solution. This reservoir is made up of flow paths at predetermined locations that constitute the piping, and in this embodiment, it includes a heat exchange flow path of the heat exchanger 3 that exchanges heat with the effluent discharge line L1 in the dialysate inlet line L1. That is, the reservoir is made up of flow paths that include the circulation line L9 located upstream (left side in FIG. 3 ) of the connection part of the dialysate inlet line L1 with the agent B stock solution inlet line L8, the heat exchange flow path of the heat exchanger 3, and the bypass line L3, and is capable of storing the aqueous sodium carbonate solution produced in the bicarbonate aqueous solution production step.

[0035] In the degreasing and washing step, as shown in FIG. 4, the tip of the dialysate inlet line L1 and the tip of the effluent discharge line L2 are kept connected by a coupler D, the solenoid valves (V1, V2, V5, V10) are opened, and the other solenoid valves are closed. Furthermore, the degassing pump 7, the duplex pump 1, the water removal pump 2, and the pressure pump P are driven. At this time, the infusion pumps (8a, 8b) are stopped. The solenoid valves (V5-V7) are opened at any timing when the bypass lines (L3-L5) are degreased and washed. This allows the sodium carbonate aqueous solution stored in the reservoir to circulate through the piping, thereby performing degreasing and washing.

[0036] Here, the control unit 13 according to this embodiment is capable of executing control to discharge carbon dioxide generated when the sodium carbonate aqueous solution is circulated to the outside of the piping while performing the degreasing and cleaning process. Specifically, the control unit 13 is configured to discharge carbon dioxide captured by the air bubble filter 10a of the capture unit 10 to the outside of the piping on the condition that the fluid pressure detection unit S1 detects a predetermined change in fluid pressure (increase in fluid pressure in this embodiment) during the degreasing and cleaning process.

[0037] That is, in the degreasing and cleaning process, carbon dioxide is captured and accumulated in the primary portion 10b of the capture unit 10, causing the fluid pressure in the secondary portion 10c to rise. When the fluid pressure detection unit S1 detects this change in fluid pressure, the solenoid valves (V4, V6, V10) are opened and the other solenoid valves are closed, and the pressure pump P is driven, as shown in FIG. 5. At this time, the degassing pump 7, duplex pump 1, water removal pump 2, and injection pumps (8a, 8b) are stopped. As a result, the carbon dioxide captured by the bubble filter 10a of the capture unit 10 and accumulated in the primary portion 10b is guided via the bypass line L4 to the waste liquid discharge line L2 and is discharged to the outside of the piping via the degassing line N2 of the degassing chamber 12.

[0038] Next, the control content by the control unit 13 according to this embodiment will be described with reference to the flowchart of FIG. First, the tip of the dialysate inlet line L1 and the tip of the waste fluid discharge line L2 are connected by a coupler D to short-circuit them, and clean water is supplied from the dialysate inlet line L1 and circulated through each flow path constituting the piping section, thereby performing a pre-cleaning operation (S1). This allows the dialysate in the piping section to be washed away.

[0039] 3, the agent B stock solution in the agent B stock solution storage tank T2 is introduced into the dialysis solution introduction line L1 (S2), and the bicarbonate aqueous solution production step is executed. As a result, the agent B stock solution is circulated through the circulation line L9 and heated by the heating unit 4 to produce a sodium carbonate (Na2CO3) aqueous solution of a predetermined concentration, and carbon dioxide (CO2) is discharged through the degassing line N1 (S3).

[0040] The produced aqueous sodium carbonate solution is stored in a storage section made up of a circulation line L9 located upstream (on the left side in FIG. 3) of the connection between the dialysate inlet line L1 and the agent B stock solution inlet line L8, a flow path including the heat exchange flow path of the heat exchanger 3, and the bypass line L3. Then, in S4, it is determined whether the amount of agent B stock solution injected has reached or exceeded a specified value, and if it is determined to be at or above the specified value, the process proceeds to S5, where a degreasing and washing step is performed.

[0041] In the degreasing and cleaning step, as shown in Figure 4, the sodium carbonate aqueous solution stored in the storage section is circulated through each flow path of the piping section by driving a duplex pump 1 or the like. Note that in the degreasing and cleaning step, tank T1 containing concentrate agent A and tank T2 containing concentrate agent B may be removed from concentrate agent A introduction line L7 and concentrate agent B introduction line L8, and the sodium carbonate aqueous solution may be circulated through concentrate agent A introduction line L7 and concentrate agent B introduction line L8 to perform degreasing and cleaning. In this way, the cleaning action of the sodium carbonate aqueous solution can remove proteins derived from the patient, and the piping section is degreased and cleaned.

[0042] Then, while the sodium carbonate aqueous solution is circulating, it is determined whether CO2 has been detected based on a change in the liquid pressure of the liquid pressure detection unit S1 (S6), and if it is determined that CO2 has been detected, the carbon dioxide captured by the air bubble filter 10a of the capture unit 10 and accumulated in the primary side portion 10b is guided to the waste liquid discharge line L2 via the bypass line L4 and is discharged to the outside of the piping via the degassing line N2 of the degassing chamber 12 (S7), as shown in Fig. 5. In other words, while the degreasing and cleaning process is being performed, the carbon dioxide generated when the sodium carbonate aqueous solution is circulated can be captured and discharged from the piping.

[0043] On the other hand, if it is determined in S6 that CO2 is not detected, a post-cleaning operation is performed by supplying clean water from the dialysate introduction line L1 and circulating it through each flow path constituting the piping section (S8). This allows the sodium carbonate aqueous solution in the piping section to be washed away. This completes the bicarbonate aqueous solution production process and the degreasing and cleaning process, and the piping section is cleaned and disinfected, allowing the blood purification treatment process to be carried out.

[0044] According to this embodiment, the carbon dioxide generated when the sodium carbonate aqueous solution is circulated is discharged to the outside of the piping while the degreasing and cleaning process is being performed, so that the agent B stock solution used in the blood purification treatment process can be reused as the alkaline agent used in the degreasing and cleaning process, and the carbon dioxide generated during the degreasing and cleaning process can be removed to ensure good degreasing and cleaning. In particular, the carbon dioxide is captured by the bubble filter 10a of the capture unit 10 when the sodium carbonate aqueous solution is circulated in the degreasing and cleaning process, so that the carbon dioxide can be reliably captured.

[0045] In addition, when the fluid pressure detection unit S1 detects a predetermined change in fluid pressure during the degreasing and cleaning process, the carbon dioxide captured by the bubble filter 10a of the capture unit 10 is discharged to the outside of the piping, so that the captured carbon dioxide can be automatically discharged to the outside of the piping. Furthermore, when the fluid pressure detection unit S1 detects a predetermined change in fluid pressure during the degreasing and cleaning process, the solenoid valve V6 (on-off valve) is opened to discharge the carbon dioxide in the primary side part 10b to the outside of the piping via the bypass line L4 and the effluent discharge line L2, so that the bypass line L4 used in the blood purification treatment process can be effectively used to discharge the carbon dioxide to the outside of the piping.

[0046] Although the present embodiment has been described above, the present invention is not limited to this, and for example, it is possible to capture and discharge carbon dioxide generated when the sodium carbonate aqueous solution is circulated while performing the degreasing and washing process using a means other than the capture unit 10. In this case, in addition to using a means used in the blood purification treatment process as in this embodiment, it may also be a dedicated capture means that is not used in the blood purification treatment process.

[0047] In this embodiment, the piping is degreased and cleaned by circulating an aqueous sodium carbonate solution obtained by introducing and heating an undiluted solution of agent B into the piping, but a bicarbonate aqueous solution other than the aqueous sodium carbonate solution may also be circulated. Furthermore, although this embodiment is applied to a personal dialysis machine, it can also be applied to other types of blood purification machines, such as a multi-person dialysis machine. [Industrial Applicability]

[0048] The present invention can be applied to blood purification devices having different external shapes or having additional functions, as long as they are equivalent to the spirit of the present invention. [Explanation of symbols]

[0049] 1. Duplex pump (liquid delivery section) 1a Suction part 1b Discharge section 2. Water removal pump 3 Heat exchanger 4 Heating section 5 Degassing section 6 Orifice 7 Degassing pump 8a, 8b Infusion pump 9a, 9b Stirring chamber 10, 11 Capture unit 10a, 11a Bubble filter 10b, 11b Primary site 10c, 11c Secondary side part 12 Degassing chamber 13 Control Unit L1 Dialysis fluid introduction line L2 drainage line L3~L5 bypass line L6 Detour Line L6a connection line L7 Agent A undiluted solution introduction line L8 B agent undiluted solution introduction line L9 Circulation Line N1, N2 degassing lines C Dialyzer (blood purifier) C1 Blood inlet C2 blood outlet C3 Dialysate inlet C4 Dialysate outlet K blood circuit K1 Arterial blood circuit K2 Venous blood circuit T1 Agent A concentrate storage tank T2 Agent B concentrate storage tank t Temperature sensor S1, S2 fluid pressure detector P Pressure pump

Claims

1. A blood purification device that circulates a patient's blood extracorporeally through a blood purifier and a blood circuit, and purifies the blood, a piping section having a dialysate introduction line for introducing dialysate into the blood purifier and a waste fluid discharge line for discharging waste fluid from the blood purifier; a liquid delivery unit that delivers liquid to the piping section; a control unit that controls the fluid delivery unit to carry out a blood purification treatment step in which a dialysis solution prepared by introducing and mixing an A agent stock solution and a B agent stock solution into the piping unit and diluting the dialysis solution to a predetermined concentration is delivered to the blood purifier, and a degreasing and cleaning step in which a bicarbonate aqueous solution obtained by introducing and heating an B agent stock solution into the piping unit is circulated to remove oil and fat from the piping unit, The control unit is configured to discharge carbon dioxide generated when the bicarbonate aqueous solution is circulated to the outside of the piping unit while performing the degreasing and cleaning process, and a trapping section that traps air bubbles contained in the dialysis fluid while allowing the dialysis fluid to pass through during the blood purification treatment step, the trapping section being connected to the dialysis fluid introduction line; a primary section upstream of the bubble filter in which the air bubbles trapped by the bubble filter are accommodated; and a secondary section downstream of the bubble filter in which the dialysis fluid that has passed through the bubble filter flows; The blood purification apparatus, wherein the bubble filter of the capture unit captures carbon dioxide when the bicarbonate aqueous solution is circulated in the degreasing and cleaning step.

2. a fluid pressure detection unit for detecting a fluid pressure on the downstream side or upstream side of the capture unit in the dialysis fluid introduction line; 2. The blood purification apparatus according to claim 1, wherein the control unit discharges the carbon dioxide captured by the capture unit to the outside of the piping unit on condition that the fluid pressure detection unit detects a predetermined change in fluid pressure during the degreasing and cleaning process.

3. The piping section has a bypass line that connects and communicates the primary side section and the waste liquid discharge line, and an on-off valve that opens and closes the bypass line to open or close the flow path, 3. The blood purification apparatus according to claim 2, wherein the control unit opens the on-off valve and discharges carbon dioxide from the primary side portion to the outside of the piping portion via the bypass line and the waste fluid discharge line, on the condition that the fluid pressure detection unit detects a predetermined change in fluid pressure during the degreasing and cleaning process.

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