Liquid topical skin composition

Abstract

To provide a liquid skin external composition that does not render skin sticky immediately after its application, secures low-temperature stability of its formulation, and exhibits an antipruritic effect to quickly act and yet last long.SOLUTION: A liquid skin external composition contains (A) a cooling agent, (B) maltotetraose and (C) a polyhydric alcohol having a molecular weight of 350 or less, characterized in that the ratio by mass [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the components (A) and (B) is 5-30 inclusive.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a liquid composition for topical application to the skin. [Background technology]

[0002] In recent years, external skin compositions that relieve itching on the skin have been required to be non-sticky immediately after application, stable at low temperatures, and have a rapid and sustained antipruritic effect.

[0003] Conventionally, techniques proposed for reducing itching on the skin include alleviating itching through the cooling sensation of L-menthol and NK1 receptor antagonist compositions such as maltooligosaccharides (see, for example, Patent Document 1). However, the composition used in Patent Document 1 required further improvement in the immediate antipruritic effect from the viewpoints of the penetration rate and amount of the active ingredient into the skin, the mechanism of action, etc. In addition, since the composition used in Patent Document 1 contains a large amount of oily ingredients, further improvement was also required in terms of stickiness on the skin after use.

[0004] In addition, an anti-itch agent has been proposed that contains maltooligosaccharide, an antipruritic agent, and an anti-inflammatory agent to suppress itching caused by pruritic components such as histamine and substance P (see, for example, Patent Document 2). However, the antipruritic agent used in Patent Document 2 does not allow the active ingredient to penetrate the skin in sufficient amounts, and further improvement in the durability of the antipruritic effect is required.

[0005] Furthermore, cosmetic compositions containing surfactants such as anionic surfactants, cationic surfactants, and amphoteric surfactants, as well as ethyl alcohol, have been proposed for the purpose of stabilizing compositions containing antipruritic active ingredients (see, for example, Patent Document 3). However, the surfactant and ethyl alcohol used in Patent Document 3 may accelerate skin dryness, and further improvement in the durability of the antipruritic effect was required. In addition, the composition used in Patent Document 3 also required further improvement in low-temperature stability, since the solubility of the ingredients is reduced if the composition does not contain a surfactant and ethanol.

[0006] Therefore, a liquid composition for external use on the skin that does not leave the skin sticky immediately after application, that has low-temperature stability, and that has an immediate and long-lasting antipruritic effect has not yet been provided, and there is currently a strong demand for its prompt development. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] International Publication No. 08 / 047709 [Patent Document 2] Japanese Patent Application Laid-Open No. 2009-221190 [Patent Document 3] Japanese Patent Application Laid-Open No. 2011-148773 Summary of the Invention [Problem to be solved by the invention]

[0008] The present invention aims to solve the above-mentioned problems of the prior art and to achieve the following objectives: to provide a liquid composition for external use on the skin that is non-sticky immediately after application, has low-temperature stability, and exhibits an antipruritic effect that is immediate and long-lasting. [Means for solving the problem]

[0009] As a result of extensive research into achieving the above-mentioned object, the inventors have found that the liquid composition for external use on skin of the present invention contains (A) a cooling agent, (B) maltotetraose, and (C) a polyhydric alcohol having a molecular weight of 350 or less, and that when the mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the components (A) and (B) is 5 or more and 30 or less, the composition does not leave sticky feeling on the skin immediately after application, the formulation has low-temperature stability, and the antipruritic effect is excellent in immediate action and long-lasting effect.

[0010] The present invention is based on the above findings of the present inventors, and the means for solving the above problems are as follows. <1> The liquid composition for topical application to the skin comprises (A) a cooling agent, (B) maltotetraose, and (C) a polyhydric alcohol having a molecular weight of 350 or less, wherein the mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the components (A) and (B) is 5 or more and 30 or less. <2> The content of the component (A) is 0.2% by mass or more and 0.4% by mass or less, based on the total amount of the liquid composition for topical skin, the content of the component (B) is 0.5% by mass or more and 1.5% by mass or less, based on the total amount of the liquid composition for topical skin, and the content of the component (C) is 15% by mass or more and 25% by mass or less, based on the total amount of the liquid composition for topical skin, <1> 1. A liquid composition for external use on skin according to claim 1. <3> The content of ethyl alcohol in the liquid composition for external use on skin is less than 1.0% by mass based on the total amount of the liquid composition for external use on skin. <1> From the above <2> The liquid composition for external application to skin is described in any one of the above. <4> The content of the surfactant in the liquid composition for external use on the skin is less than 1.0% by mass based on the total amount of the liquid composition for external use on the skin, and the surfactant is at least one selected from an anionic surfactant, a cationic surfactant, and an amphoteric surfactant. <1> From the above <3> The liquid composition for external application to skin is described in any one of the above. <5> The content of purified water in the liquid composition for external use on skin is 60% by mass or more based on the total amount of the liquid composition for external use on skin. <1> From the above <4> The liquid composition for external application to skin is described in any one of the above. <6> The above-mentioned leave-in type <1> From the above <5> The liquid composition for external application to skin is described in any one of the above. <7> The above-mentioned mist spray container <1> From the above <6> The liquid composition for external application to skin is described in any one of the above. [Effects of the Invention]

[0011] According to the present invention, the above-mentioned problems of the prior art can be solved, the above-mentioned object can be achieved, and a liquid composition for external use on the skin can be provided which does not leave the skin sticky immediately after application, has low-temperature stability of the formulation, and has an excellent immediate and long-lasting antipruritic effect. DETAILED DESCRIPTION OF THE INVENTION

[0012] (Liquid skin external composition) The liquid composition for external use on skin of the present invention contains (A) a cooling agent, (B) maltotetraose, and (C) a polyhydric alcohol having a molecular weight of 350 or less, and may contain other ingredients as needed. In this specification, (A) the cooling agent may be referred to as "(A) component," (B) maltotetraose may be referred to as "(B) component," and (C) the polyhydric alcohol having a molecular weight of 350 or less may be referred to as "(C) component" or "(C) polyhydric alcohol."

[0013] <(A) Cooling agent> The cooling agent (A) is contained to improve the immediate effectiveness of the antipruritic effect.

[0014] The cooling agent (A) is not particularly limited and can be appropriately selected depending on the purpose, but from the viewpoint of improving the immediate antipruritic effect and the low-temperature stability of the preparation, L-menthol, menthyl lactate, menthyl acetate, L-menthyl glyceryl ether, N-ethyl-p-menthane-3-carboxamide, and peppermint oil are preferred, L-menthol and N-ethyl-p-menthane-3-carboxamide are more preferred, and L-menthol is particularly preferred. These may be used alone or in combination of two or more.

[0015] The L-menthol can be represented by the following structural formula: [ka]

[0016] The component (A) may be an appropriately synthesized product or a commercially available product. The method for synthesizing the component (A) is not particularly limited and can be appropriately selected depending on the purpose.

[0017] Examples of commercially available cooling agents (A) include L-menthol (manufactured by Takasago International Corporation), menthyl lactate Frescolat ML (manufactured by Symrise), and peppermint oil (manufactured by Nagaoka Jitsugyo Co., Ltd.).

[0018] The content of the component (A) in the liquid composition for topical application of the present invention is not particularly limited and can be selected appropriately depending on the purpose. However, from the viewpoint of achieving an immediate antipruritic effect and excellent low-temperature stability of the preparation, the content is preferably 0.1% by mass or more and 0.5% by mass or less, and more preferably 0.2% by mass or more and 0.4% by mass or less, based on the total amount of the liquid composition for topical application of the present invention. When the content of the component (A) is 0.1% by mass or more based on the total amount of the liquid composition for external use on skin, the problem of reduced immediate antipruritic effect can be solved, which is preferable. When the content of the component (A) is 0.5% by mass or less based on the total amount of the liquid composition for external use on skin, the problem of decreased low-temperature stability of the preparation can be solved, which is preferable.

[0019] <(B) Maltotetraose> The (B) maltotetraose is contained to improve the durability of the antipruritic effect. Generally, maltotetraose has an NK1 (new quinolone 1) receptor antagonistic activity and suppresses itching caused by ingredients such as substance P. Furthermore, the maltotetraose forms a film on the surface of the liquid composition for topical skin, thereby inhibiting the volatilization of the cooling agent component (A) and improving the durability of the antipruritic effect.

[0020] The (B) maltotetraose may be suitably synthesized or may be a commercially available product. The method for synthesizing (B) maltotetraose is not particularly limited and can be appropriately selected depending on the purpose.

[0021] Examples of commercially available products of (B) maltotetraose include Leoguard MT (manufactured by Lion Specialty Chemical Co., Ltd.) and Tetrap (manufactured by Hayashibara Co., Ltd.).

[0022] The content of component (B) in the liquid composition for topical application of the present invention is not particularly limited and can be selected appropriately depending on the purpose. However, from the viewpoint of achieving an excellent immediate and long-lasting antipruritic effect and a satisfactory lack of stickiness on the skin immediately after application, the content is preferably 0.1% by mass or more and 3.0% by mass or less, and more preferably 0.5% by mass or more and 1.5% by mass or less, relative to the total amount of the liquid composition for topical application of the present invention. When the content of the component (B) is 0.1% by mass or more relative to the total amount of the liquid composition for external use on skin, the problem of reduced immediate action and duration of the antipruritic effect can be solved, which is preferable. If the content of the component (B) is 3.0% by mass or less relative to the total amount of the liquid composition for external use on skin, the problem of the skin feeling sticky immediately after use of the liquid composition for external use on skin can be solved, which is preferable.

[0023] <(C) Polyhydric alcohol with a molecular weight of 350 or less> The (C) polyhydric alcohol having a molecular weight of 350 or less is contained to improve the immediate and sustained antipruritic effect. The polyhydric alcohol having a molecular weight of 350 or less in the present invention can impart an immediate antipruritic effect by suppressing the volatilization of the cooling sensation agent (A) and can also impart a sustained antipruritic effect by promoting the penetration of the maltotetraose (B) into the skin.

[0024] The component (C) is not particularly limited and can be selected appropriately depending on the purpose. However, from the viewpoint of providing an antipruritic effect that is immediate and lasting, and not leaving the skin sticky immediately after use, ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, pentylene glycol, dibutylene glycol, glycerin, diglycerin, polyglycerin, sucrose, lactose, maltose, mannitol, erythritol, and xylitol are preferred, and butylene glycol and glycerin are more preferred.

[0025] The component (C) may be an appropriately synthesized product or a commercially available product. The method for synthesizing the component (C) is not particularly limited and can be appropriately selected depending on the purpose.

[0026] Examples of commercially available products of the component (C) include butylene glycol (manufactured by OQ Chemicals Japan Co., Ltd.), Propylene Glycol JSQI (manufactured by The Dow Chemical Company), dipropylene glycol (manufactured by AGC Corporation), and cosmetic glycerin (manufactured by Sakamoto Pharmaceutical Industry Co., Ltd.).

[0027] The content of the (C) component in the liquid composition for topical application of the present invention is not particularly limited and can be selected appropriately depending on the purpose. However, from the viewpoint of achieving an excellent immediate and long-lasting antipruritic effect and a satisfactory lack of stickiness on the skin immediately after use, the content is preferably 10% by mass or more and 30% by mass or less, and more preferably 15% by mass or more and 25% by mass or less, based on the total amount of the liquid composition for topical application of the present invention. If the content of the (C) component is 10% by mass or more relative to the total amount of the liquid skin topical composition, problems such as the immediate and sustained antipruritic effect and reduced low-temperature stability of the formulation can be resolved, which is preferable. If the content of the component (C) is 30% by mass or less relative to the total amount of the liquid composition for external use on the skin, the problem of the skin feeling sticky immediately after use of the liquid composition for external use on the skin can be solved, which is preferable.

[0028] The method for measuring the molecular weight of the polyhydric alcohol (C) is not particularly limited, but it can be measured by mass spectrometry. Specifically, the molecular weight of the polyhydric alcohol can be measured by gas chromatography mass spectrometry.

[0029] <Mass ratio [(C) / {(A)+(B)}]> In the present invention, the mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B) is 5 or more and 30 or less, from the viewpoints of achieving an excellent immediate and long-lasting antipruritic effect, a satisfactory lack of stickiness on the skin immediately after use, and improved low-temperature stability of the preparation. In the present invention, the mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the components (A) and (B) is preferably 7 or more and 20 or less. In this specification, the "mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B)" may be referred to as the "mass ratio."

[0030] A mass ratio of 5 or more is preferable because it can solve the problems of durability and immediate action of the antipruritic effect, as well as the decrease in the low-temperature stability of the preparation. A mass ratio of 30 or less is preferable because it can eliminate problems such as a decrease in the durability and immediate action of the antipruritic effect and stickiness of the skin immediately after application of the liquid composition for external use on the skin.

[0031] <Other ingredients> In addition to the components (A), (B), and (C), the liquid composition for external use on skin of the present invention may contain other components as needed, provided that the effects of the present invention are not impaired. Examples of the other ingredients include ethyl alcohol, surfactants, water-soluble polymers, oils, celluloses, keratolytic agents, anti-inflammatory agents, antihistamine compound drugs, silicones, alcohols other than ethyl alcohol, drugs such as lanolin derivatives, protein derivatives, amino acids and vitamins, disinfectants, moisturizers, preservatives, thickeners, pH adjusters such as potassium hydroxide, citric acid and hydrochloric acid, antioxidants, sequestering agents, UV absorbers, UV scattering agents, animal and plant extracts or derivatives thereof, chelating agents such as edetic acid, colorants, fragrances, pigments, inorganic powders, clay minerals, water-insoluble polymer compound powders such as nylon and polyethylene, and purified water. These may be used alone or in combination of two or more. The other components may be appropriately synthesized or commercially available. The content of the other ingredients in the liquid composition for external use on skin is not particularly limited and can be appropriately selected depending on the purpose.

[0032] <<Ethyl alcohol>> The liquid composition for external use on skin of the present invention may contain ethyl alcohol in addition to the component (A), the component (B), and the component (C).

[0033] The content of the ethyl alcohol is preferably less than 1.0% by mass based on the total amount of the liquid composition for external use on skin, from the viewpoint of improving the durability of the antipruritic effect. If the content of the ethyl alcohol is less than 1.0% by mass relative to the total amount of the liquid composition for external use on skin, problems such as accelerated dryness of the skin and reduced durability of the antipruritic effect can be solved, which is preferable.

[0034] The ethyl alcohol may be appropriately synthesized or may be a commercially available product. The method for synthesizing the ethyl alcohol is not particularly limited and can be appropriately selected depending on the purpose.

[0035] Examples of commercially available ethyl alcohol include 95% synthetic specific alcohol (manufactured by Japan Synthetic Alcohol Co., Ltd.).

[0036] <<Surfactants>> The liquid composition for external use on skin of the present invention may contain a surfactant in addition to the components (A), (B), and (C). The surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include anionic surfactants, cationic surfactants, and amphoteric surfactants.

[0037] <<Anionic surfactants>> Specific examples of the anionic surfactant include higher fatty acid salts, polyoxyethylene (POE) alkyl ether sulfates, ether carboxylates, amino acid surfactants, etc. Among these, higher fatty acid salts are preferred. These may be used alone or in combination of two or more.

[0038] -Higher fatty acid salts- The higher fatty acid salt is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include laurate, myristate, palmitate, stearate, etc. Among these, laurate and myristate are preferred. These may be used alone or in combination of two or more.

[0039] The salt in the higher fatty acid salt is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include alkali metal salts, amine salts, and amino acid salts. The alkali metal salt is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include sodium salts and potassium salts. The amine salt is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include ammonium salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, and alkanolamine salts such as 2-amino-2-methylpropanol and 2-amino-2-methylpropanediol. The amino acid salt is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include lysine salt and arginine salt. Among these, alkali metal salts are preferred, and potassium salts are more preferred.

[0040] The higher fatty acid salt may be suitably synthesized or may be a commercially available product. The method for synthesizing the higher fatty acid salt is not particularly limited and can be appropriately selected depending on the purpose. For example, a fatty acid salt obtained by a conventional method may be blended as is, or the higher fatty acid salt may be synthesized by neutralizing a higher fatty acid with an alkali such as potassium hydroxide in a blending tank during the blending process of the liquid composition for topical skin.

[0041] Examples of commercially available higher fatty acid salts include, by trade name, NIKKOL potassium laurate LK-120 (potassium laurate), NIKKOL potassium myristate MK-140 (potassium myristate), Tysoap MNK-40 (potassium coconut oil fatty acid) (all manufactured by Nikko Chemicals Co., Ltd.), and Nonsal PK-1 (potassium palmitate) (manufactured by NOF Corporation).

[0042] -Polyoxyethylene (POE) alkyl ether sulfate- The polyoxyethylene alkyl ether sulfate is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include compounds represented by the following general formula (A1). The polyoxyethylene alkyl ether sulfates may be used alone or in combination of two or more.

[0043] [ka] In the general formula (A1), R 7 represents an alkyl group, and the alkyl group moiety preferably has 10 to 14 carbon atoms. In the general formula (A1), n ​​represents the average number of moles of ethylene oxide (EO) added, and the average number of moles of ethylene oxide added is preferably 1 to 5. In the general formula (A1), X represents an alkali metal or ammonium. The alkali metal is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include sodium and potassium.

[0044] Specific examples of the polyoxyethylene alkyl ether sulfates include polyoxyethylene (1) sodium lauryl ether sulfate, polyoxyethylene (2) sodium lauryl ether sulfate (also known as POE (2) sodium laureth sulfate), polyoxyethylene (3) sodium lauryl ether sulfate (also known as POE (3) sodium laureth sulfate), polyoxyethylene (4) sodium lauryl ether sulfate, polyoxyethylene (5) sodium lauryl ether sulfate, polyoxyethylene (3) sodium alkyl (C12,13) ​​ether sulfate, polyoxyethylene (2) lauryl ether ammonium sulfate, and polyoxyethylene (3) lauryl ether ammonium sulfate. The value in the parentheses indicates the average number of moles (n) of ethylene oxide (EO) added.

[0045] The polyoxyethylene alkyl ether sulfate may be suitably synthesized or may be a commercially available product. Examples of commercially available polyoxyethylene alkyl ether sulfates include Texapon (registered trademark) N70 (polyoxyethylene (2) lauryl ether sodium sulfate) (manufactured by BASF) and Shinorin SPE-1250 (polyoxyethylene (2) lauryl ether sodium sulfate) (manufactured by New Japan Chemical Co., Ltd.).

[0046] -Ether carboxylate- The ether carboxylate is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include compounds represented by the following general formula (A2) or (A3). The ether carboxylates may be used alone or in combination of two or more.

[0047] [ka] In the general formulas (A2) and (A3), R 8 represents a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, or a phenyl group substituted with a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, and the R 8 The moiety preferably has 10 to 14 carbon atoms. In the general formula (A2), R 9 may be the same or different and represent an alkylene group having 2 to 4 carbon atoms, preferably 2 carbon atoms. In the general formula (A2), o represents an average number of moles of alkylene oxide added of 1 to 20, and the average number of moles of alkylene oxide added is preferably 1 to 5. In the general formulas (A2) and (A3), M 1 represents a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, or a basic amino acid.

[0048] Specific examples of the ether carboxylate salt represented by the general formula (A2) or (A3) include polyoxyethylene (3) lauryl ether sodium acetate, polyoxyethylene (4) lauryl ether potassium acetate, and sodium lauryl glycol acetate. The numerical value in the parentheses indicates the average number of moles (o) of alkylene oxide added.

[0049] The ether carboxylate may be an appropriately synthesized product or a commercially available product. Commercially available ether carboxylates include, for example, Energicol EC-30 (polyoxyethylene (3) lauryl ether sodium acetate) (manufactured by Lion Specialty Chemicals Co., Ltd.), Viewlite LCA-25F (polyoxyethylene (3) lauryl ether sodium acetate), Viewlite LCA-30D (polyoxyethylene (3) lauryl ether sodium acetate), Viewlite LCA-H (polyoxyethylene (4) lauryl ether acetic acid), Viewlite LCA-25NH (laureth-4 carboxylic acid), Viewlite SHAA (sodium lauryl glycol carboxylate), Viewlite LCA (polyoxyethylene (3) lauryl ether sodium acetate) (all manufactured by Sanyo Chemical Industries, Ltd.), Kao Akipo RLM-45NV (polyoxyethylene (4.5) lauryl ether sodium acetate), and Kao Akipo RLM-100NV (polyoxyethylene (10) lauryl ether sodium acetate) (all manufactured by Kao Corporation). The numerical value in the parentheses indicates the average number of moles (o) of alkylene oxide added.

[0050] -Amino acid surfactant- The amino acid-based surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include compounds represented by the following general formula (A4). The amino acid-derived surfactants may be used alone or in combination of two or more.

[0051] [ka] In the general formula (A4), R 10 represents a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, or a phenyl group substituted with a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, and 10 The carbon number of the moiety is preferably 8 to 18. In the general formula (A4), R 11 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. In the general formula (A4), R 12 and R 13 may be the same or different and are a hydrogen atom or -(CH2) m -COOM 2 Shows. In the general formula (A4), m and n may be the same or different and represent a number of 0 to 20. In the general formula (A4), M 1 and M 2 may be the same or different and represent a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, or a basic amino acid.

[0052] The amino acid structure of the hydrophilic portion of the amino acid surfactant is not particularly limited and can be appropriately selected depending on the purpose, but glycine, glutamic acid, and methylalanine are preferred.

[0053] Specific examples of the amino acid surfactant represented by general formula (A4) include N-acylglycines and salts thereof, such as N-cocoylglycine potassium (N-cocoylglycine potassium), N-acyl-N-carboxyethylglycines and salts thereof, such as N-myristoyl-N-carboxyethylglycine sodium, N-acylglutamic acids and salts thereof, such as sodium N-myristoyl-L-glutamate, potassium N-myristoyl-L-glutamate, potassium N-cocoyl-L-glutamate, sodium N-palm acyl-L-glutamate, and sodium N-stearoyl-L-glutamate, and N-lauroyl-N-methyl-β-alanine potassium.

[0054] The amino acid-based surfactant may be suitably synthesized or may be a commercially available product. Commercially available amino acid surfactants include, for example, Amirite (registered trademark) GCK-11 (potassium N-coconut oil fatty acid acylglycine), Amirite (registered trademark) GCK-12K (potassium N-coconut oil fatty acid acylglycine), Amirite (registered trademark) GCS-12K (sodium N-coconut oil fatty acid acylglycine), Amirite (registered trademark) GCS-11 (sodium N-coconut oil fatty acid acylglycine), Amisoft (registered trademark) CS-11 (sodium N-myristoyl-L-glutamate), Amisoft (registered trademark) CS-22 (sodium N-coconut oil fatty acid acyl-L-glutamate), Amisoft (registered trademark) LS-11 (sodium N-lauroyl-L-glutamate), and Amisoft (registered trademark) CS-22 (sodium N-coconut oil fatty acid acyl-L-glutamate). sodium glutamate), Amisoft® MS-11 (N-myristoyl-L-glutamate sodium), Amisoft® HS-11P (N-stearoyl-L-glutamate sodium), Amisoft® HS-11P(F) (N-stearoyl-L-glutamate sodium), Amisoft® HS21 (N-stearoyl-L-glutamate disodium), Amirite® ACS-12 (cocoylalanine sodium) (all manufactured by Ajinomoto Healthy Supply Co., Ltd.), AminoSurfact® AMMS-P1 (N-myristoyl-L-glutamate sodium) (manufactured by Asahi Kasei Chemicals Corporation), NIKKOL Examples include Sarcosinate MN (sodium myristoyl methylaminoacetate), NIKKOL Alaninate LN-30 (sodium lauroyl methyl-β-alanine) (all manufactured by Nikko Chemicals Co., Ltd.), Alanon ACE (sodium coconut oil fatty acid methylalanine), Alanon AME (sodium myristoyl methyl-β-alanine), Alanon ALE (sodium lauroyl methyl-β-alanine) (all manufactured by Kawaken Fine Chemicals Co., Ltd.), Energicol L-30AN (sodium lauroyl methyl-β-alanine) (manufactured by Lion Specialty Chemicals Co., Ltd.), and Softilt AT-L (sodium lauroyl methyl-β-alanine) (manufactured by NOF Corporation).

[0055] <<Nonionic surfactants>> The nonionic surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include polyoxyethylene alkyl ether (hereinafter also referred to as "POE alkyl ether") having an average number of moles of ethylene oxide added of 40 to 120, fatty acid monoethanolamide, etc. These may be used alone or in combination of two or more.

[0056] -POE alkyl ether- The average number of moles of ethylene oxide (EO) added to the POE alkyl ether (average number of moles of EO added) is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 40 to 120, more preferably 50 to 100, and particularly preferably 70 to 100. The alkyl group in the POE alkyl ether preferably has 10 to 22 carbon atoms, and more preferably 12 to 18 carbon atoms.

[0057] The POE alkyl ether may be an appropriately synthesized product or a commercially available product. Examples of commercially available products include Emalex 550 (POE (50) oleyl ether), Emalex 750 (POE (50) lauryl ether) (manufactured by Nippon Emulsion Co., Ltd.), Nonion K-2100W (POE (100) lauryl ether, manufactured by NOF Corporation), and Brownon SR-750 (POE (50) stearyl ether, manufactured by Aoki Oil & Fat Industries Co., Ltd.). The number in parentheses after POE indicates the average number of moles of ethylene oxide added.

[0058] -Fatty acid monoethanolamide- The number of carbon atoms of the fatty acid in the fatty acid monoethanolamide is preferably 8 to 18.

[0059] The fatty acid monoethanolamide may be suitably synthesized or may be a commercially available product. Examples of the commercially available products include Amizole CME (coconut oil fatty acid monoethanolamide) and Amizole SME (stearic acid monoethanolamide) (both manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0060] <<<Amphoteric surfactants>>> The amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include alkylbetaine-type amphoteric surfactants, amidobetaine-type amphoteric surfactants, sulfobetaine-type amphoteric surfactants, hydroxysulfobetaine-type amphoteric surfactants, amidosulfobetaine-type amphoteric surfactants, phosphobetaine-type amphoteric surfactants, imidazoline-type amphoteric surfactants, amine oxide-type amphoteric surfactants, etc. These may be used alone or in combination of two or more.

[0061] The alkyl betaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl dimethylaminoacetic acid betaine, lauryl betaine, etc. These may be used alone or in combination of two or more.

[0062] The amidobetaine amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauric acid amidopropyl betaine (lauramidopropyl betaine), stearyl dimethylaminoacetic acid betaine, cocamidopropyl betaine (coconut oil fatty acid amidopropyl betaine), etc. These may be used alone or in combination of two or more.

[0063] The sulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include coconut oil fatty acid dimethyl sulfopropyl betaine, etc. These may be used alone or in combination of two or more.

[0064] The hydroxysulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl hydroxysultaine, etc. These may be used alone or in combination of two or more.

[0065] The amidosulfobetaine amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include cocamidopropyl hydroxysultaine, lauramidopropyl hydroxysultaine, etc. These may be used alone or in combination of two or more.

[0066] The phosphobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl hydroxyphosphobetaine, etc. These may be used alone or in combination of two or more.

[0067] The imidazoline-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include coconut oil alkyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, etc. These may be used alone or in combination of two or more.

[0068] The amine oxide type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl dimethylamine oxide, coconut oil alkyl dimethylamine oxide, etc. These may be used alone or in combination of two or more.

[0069] The amphoteric surfactant may be suitably synthesized or may be a commercially available product. Commercially available amphoteric surfactants include, for example, NIKKOL AM-3130N (cocamidopropyl betaine, manufactured by Nikko Chemicals Co., Ltd.), TEGO Betaine (cocamidopropyl betaine, manufactured by Evonik), Amphitol 20AB (lauric acid amidopropyl betaine, manufactured by Kao Corporation), MITAINE L (lauryl betaine, manufactured by Miwon Commercial), Amphorex LSB (lauryl hydroxysultaine, manufactured by Miyoshi Oil & Fats Co., Ltd.), Amphitol 20HD (lauryl hydroxysultaine, manufactured by Kao Corporation), Softazoline LSB (lauramidopropyl hydroxysultaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), and Softazoline. Examples include CH (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.), Amphitol 20N (lauryl dimethylamine oxide, manufactured by Kao Corporation), and Unisafe (registered trademark) A-LM (lauryl dimethylamine oxide, manufactured by NOF Corporation).

[0070] The total content of the surfactants is not particularly limited and can be selected appropriately depending on the purpose, but from the viewpoint of improving the durability of the antipruritic effect, it is preferable that the total content be less than 1.0 mass% of the total amount of the liquid topical skin composition. If the total content of the surfactants is less than 1.0% by mass relative to the total amount of the liquid composition for topical skin, problems such as accelerated dryness of the skin and reduced durability of the antipruritic effect can be solved, which is preferable.

[0071] <<Cellulose>> The celluloses are not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropylmethyl cellulose. The content of the cellulose is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.05% by mass or more and 1.0% by mass or less based on the total amount of the liquid composition for external use on skin.

[0072] <<Anti-inflammatory agent>> The anti-inflammatory agent is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include dexamethasone, dexamethasone acetate, clobetasone, clobetasone acetate, glycyrrhizinic acid, glycyrrhetinic acid, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate. The content of the anti-inflammatory agent is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.01% by mass or more and 1.0% by mass or less based on the total amount of the liquid composition for external use on skin.

[0073] <<Antihistamine compound drugs>> The antihistamine compound drug is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include hydroxyphenylpropamidobenzoic acid, acrivastine, brompheniramine, chlorpheniramine, dexchlorpheniramine, dimethindene, triprolidine, bromodiphenhydramine, clemastine, phenyltoloxamine, piprine hydrinate, pyrilamine, tripelennamine, cetirizine, hydroxyzine, methdilazine, promethazine, trimeprazine, azatadine, cyproheptadine, loratadine, astemizole, diphenhydramine, levocabastine, and terfenadine. The content of the antihistamine compound is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.005% by mass or more and 0.5% by mass or less based on the total amount of the liquid composition for external use on skin.

[0074] The hydroxyphenylpropamidobenzoic acid can be represented by the following structural formula: [ka]

[0075] <<Oil content>> The oil is not particularly limited and can be appropriately selected depending on the purpose. Examples include vegetable oils and fats such as castor oil, olive oil, cacao oil, hardened palm oil, camellia oil, coconut oil, Japan wax, jojoba oil, grapeseed oil, and avocado oil, and ester compounds thereof; animal oils and fats such as mink oil and egg yolk oil; waxes such as beeswax, spermaceti, lanolin, hydrogenated lanolin, carnauba wax, and candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, and petrolatum; natural and synthetic fatty acids such as oleic acid, isostearic acid, and behenic acid; and esters such as glycerol tri-2-ethylhexanoate, 2-ethylhexyl stearate, butyl stearate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate. The content of the oil is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass or more and 10% by mass or less based on the total amount of the liquid composition for external use on skin.

[0076] <<Alcohols other than ethyl alcohol>> The alcohols other than ethyl alcohol are not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include natural and synthetic higher alcohols such as cetyl alcohol, oleyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, and lauryl alcohol. The content of the alcohols other than ethyl alcohol is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass or more and 10% by mass or less based on the total amount of the liquid composition for external use on skin.

[0077] <<Moisturizer>> The moisturizer is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include isoprene glycol, 1,2-pentanediol, diethylene glycol, diethylene glycol monoalkyl ether, polypropylene glycol, hydrogenated castor oil (30 E.O.), diglycerin, triglycerin, polyglycerins, trehalose, glycosyl trehalose, and hydrogenated starch hydrolysates. The content of the moisturizer is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.05% by mass or more and 10% by mass or less based on the total amount of the liquid composition for external use on skin.

[0078] <<Preservatives>> The preservative is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include ethylhexylglycerin, benzoates, sorbates, dehydroacetates, parahydroxybenzoates, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, benzalkonium chloride, hinokitiol, resorcinol, methylchloroisothiazolinone-methylisothiazolinone solution (trade name: Cason CG, manufactured by Rohm and Haas Japan), salicylic acid, pentanediol, phenoxyethanol, and ethanol. The content of the preservative is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the liquid composition for external use on skin.

[0079] <<Antioxidants>> The antioxidant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include dibutylhydroxytoluene, butylhydroxyanisole, and ascorbic acid. The content of the antioxidant is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the liquid composition for external use on skin.

[0080] <<Chelating agent>> The chelating agent is not particularly limited and can be appropriately selected according to the purpose. For example, disodium edetate, ethylenediaminetetraacetate, hexametaphosphate, gluconic acid, etc. can be mentioned. The content of the chelating agent is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the liquid skin topical composition.

[0081] <<pH adjuster>> The pH adjuster is not particularly limited and can be appropriately selected according to the purpose. For example, sodium hydroxide, potassium hydroxide, citric acid, sodium citrate, succinic acid, triethanolamine, aqueous ammonia, triisopropanolamine, phosphoric acid, glycolic acid, etc. can be mentioned.

[0082] <<UV absorber and UV scatterer>> The UV absorber and the UV scatterer are not particularly limited and can be appropriately selected according to the purpose. For example, 2-hydroxy-4-methoxybenzophenone, octyldimethyl para-aminobenzoate, ethylhexyl paramethoxysalicylate, titanium oxide, kaolin, talc, etc. can be mentioned. The content of the UV absorber and the UV scatterer is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 0.01% by mass or more and 10% by mass or less based on the total amount of the liquid skin topical composition.

[0083] <<Vitamins>> The vitamins are not particularly limited and can be appropriately selected according to the purpose. For example, vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid and its derivatives, etc. can be mentioned. The content of the vitamins is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 0.001% by mass or more and 0.5% by mass or less based on the total amount of the liquid skin topical composition.

[0084] <<Amino acids>> The amino acids are not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine, and derivatives thereof. The content of the amino acids is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.001% by mass or more and 0.5% by mass or less based on the total amount of the liquid composition for external use on skin.

[0085] <<Thickener>> The thickener is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include gellan gum, guar gum, carboxyvinyl polymer, and xanthan gum. The content of the thickener is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.005% by mass or more and 1.0% by mass or less based on the total amount of the liquid composition for external use on skin.

[0086] <<Purified water>> The content of purified water in the liquid composition for topical use of the present invention is not particularly limited and can be selected appropriately depending on the purpose, but from the viewpoint of improving the immediate effectiveness of the antipruritic effect, it is preferable that the content be 60% by mass or more of the total amount of the liquid composition for topical use of skin. When the content of the purified water is 60% by mass or more based on the total amount of the liquid composition for external use on skin, the problem of reduced immediate antipruritic effect can be solved, which is preferable.

[0087] <ph> The pH of the liquid composition for external use on skin at 25°C is preferably 5.0 to 7.0, and more preferably 5.5 to 6.5. The method for measuring the pH is not particularly limited, and examples thereof include a method using a glass electrode color hydrogen ion concentration indicator HM-30R (manufactured by DKK-TOA Corporation, electrode type GST-5721).

[0088] <Viscosity> The viscosity of the liquid composition for external use on skin at 25°C is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 4 mPa·s or more and 40 mPa·s or less, and more preferably 8 mPa·s or more and 30 mPa·s or less. The method for measuring the viscosity is not particularly limited, but examples include a method using a BM type viscometer (manufactured by Tokyo Keiki Co., Ltd.) to measure the viscosity after 1 minute at a sample temperature of 25°C, a rotation speed of 60 rpm, and a No. 3 rotor.

[0089] <Container> The container for filling the liquid composition for external use on skin of the present invention is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include mist sprays, tubes, etc. Among these, mist sprays are preferred.

[0090] <Method of manufacturing a liquid composition for topical use on skin> The method for producing the liquid topical skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose. The liquid topical skin composition can be obtained by mixing the above-mentioned component (A), component (B), component (C), and, if necessary, the above-mentioned other components, and purified water (blended as the remainder so that the liquid topical skin composition becomes 100% by mass). In a specific example of a method for producing the liquid skin topical composition, a polyhydric alcohol, maltotetraose, a nonionic surfactant, etc. are added to purified water heated to 70-80°C and stirred until homogeneous. Then, an oil-soluble component such as hydroxyphenylpropamidobenzoic acid is gradually added with stirring and stirred until homogeneous. The temperature is then gradually lowered to 40°C or below, and L-menthol is gradually added with stirring and stirred until homogeneous.

[0091] The liquid composition for topical use on skin may be prepared using an apparatus that is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include a stirring apparatus equipped with stirring blades that exert shear force and can mix the entire composition. The stirring blade is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include a propeller, a turbine, and a disperser.

[0092] <Application> The use of the liquid composition for external use on the skin is not particularly limited and can be appropriately selected depending on the purpose, but it is preferably a leave-on liquid composition for external use on the skin. Specific examples of uses of the liquid skin topical composition include pharmaceuticals and cosmetics. [Example]

[0093] The present invention will be explained in more detail below based on examples and comparative examples, but the present invention is not limited to these examples. The content of each component in the examples, comparative examples, and formulation examples is shown in "% by mass" and is a value converted into a pure content.

[0094] (Examples 1 to 15 and Comparative Examples 1 to 6) Liquid compositions for external use on the skin having the compositions and contents shown in Tables 1 to 4 below were prepared by the following method. The polyhydric alcohol, maltotetraose, and other ingredients were dissolved in purified water maintained at 70°C with stirring, then cooled to 40°C or below, and the cooling agent was then dissolved with stirring to obtain the desired liquid skin topical compositions of Examples 1 to 15 and Comparative Examples 1 to 6. Stirring was carried out using a Three-One Motor (HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.), and a propeller was used as the stirring blade.

[0095] The obtained liquid compositions for external use on skin of Examples 1 to 15 and Comparative Examples 1 to 6 were evaluated and judged for "immediate and sustained antipruritic effect," "non-stickiness of skin immediately after use," and "low-temperature stability of the preparation." The results are shown in Tables 1 to 4 below.

[0096] <Evaluation of immediate and sustained antipruritic effects> The obtained liquid compositions for external use on skin of Examples 1 to 15 and Comparative Examples 1 to 6 were filled into mist spray containers (P28-150DX, manufactured by Gracel Co., Ltd.). Ten evaluators (five men and five women) who experienced moderate and severe itching according to the following [Itch Intensity Evaluation Criteria] at the time of evaluation were assigned to apply one push (0.15 g / 10 cm × 15 cm) of each liquid skin topical composition of Examples 1 to 15 and Comparative Examples 1 to 6 to the itchy area. 10 seconds and 24 hours after application, the itching intensity was evaluated sensorily according to the following evaluation criteria. The degree of itching relief for each evaluator at each evaluation time point was calculated as "(itch intensity before application) - (itch intensity after a certain time has passed since application)," and the average score of the 10 evaluators was calculated and evaluated according to the following evaluation criteria. The evaluation 10 seconds after application indicates the "immediate effect" of the liquid skin topical composition of the present invention, and the evaluation 24 hours after application indicates the "sustainability" of the liquid skin topical composition of the present invention. [Evaluation criteria for itching intensity] 4 points: intense itching 3 points: Moderate itching 2 points: Mild itching 1 point: slight itching 0 points: No itching (no itching at all) [Criteria for assessing antipruritic effect] ◎: Itching reduction level is 3.5 to 4.0 points ◎~○: Itching reduction level is 3.0 points or more but less than 3.5 points ○: Itching reduction level is 2.5 points or more but less than 3.0 points ○~△: Itching reduction level is 2.0 points or more but less than 2.5 points △: Itching reduction level is 1.5 points or more but less than 2.0 points △~×: Itching reduction level is 1.0 points or more but less than 1.5 points ×: Itching relief level is less than 1.0 points

[0097] <Evaluation of non-stickiness of skin immediately after use> The obtained liquid compositions for external use on skin of Examples 1 to 15 and Comparative Examples 1 to 6 were filled into mist spray containers (P28-150DX, manufactured by Gracel Co., Ltd.). One push (0.15 g / 10 cm x 15 cm) of each liquid skin topical composition of Examples 1 to 15 and Comparative Examples 1 to 6 was applied. Evaluation was performed based on the following evaluation criteria. The average scores of 10 evaluators were calculated, and the non-stickiness of the skin was evaluated based on the following evaluation criteria. [Evaluation criteria for non-stickiness of skin immediately after use] 5 points: No sticky feeling on the skin at all 4 points: Skin feels slightly sticky 3 points: Skin feels sticky 2 points: Skin feels very sticky 1 point: Skin feels very sticky [Criteria for determining whether skin feels non-sticky immediately after use] ◎: 4.5 points or more and 5.0 points or less ○: 4.0 points or more and less than 4.5 points △: 3.0 points or more and less than 4.0 points ×: Less than 3.0 points

[0098] <Evaluation of low temperature stability> The obtained liquid skin topical compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were placed in polyethylene containers (50 mL) and stored at 10°C for 1 month, after which the appearance of the liquid skin topical compositions was visually evaluated according to the following method. [Criteria for low temperature stability] ◎: No change 〇: Slightly cloudy △: Cloudy ×: Precipitation of components is observed

[0099] [Table 1]

[0100] [Table 2]

[0101] [Table 3]

[0102] [Table 4]

[0103] (Prescription Examples 1-10) Liquid compositions for external use on the skin having the compositions and contents shown in Tables 5 and 6 below were prepared by a conventional method, to obtain liquid compositions for external use on the skin of Formulation Examples 1 to 10.

[0104] [Table 5]

[0105] [Table 6]

[0106] Details of each component used in Examples 1 to 15, Comparative Examples 1 to 6, and Formulation Examples 1 to 10 are shown in Table 7 below.

[0107] [Table 7] [Industrial Applicability]

[0108] The liquid skin topical composition of the present invention is highly effective in alleviating and treating skin diseases because it does not leave the skin sticky immediately after application, the formulation is stable at low temperatures, and the antipruritic effect is immediate and long-lasting. It is also suitable for use on a daily basis as a pharmaceutical, cosmetic, etc.< / ph>

Claims

1. (A) a cooling agent; (B) maltotetraose, (C) a polyhydric alcohol having a molecular weight of 350 or less, the content of the component (C) is 10% by mass or more and 30% by mass or less relative to the total amount of the liquid composition for topical skin; A liquid composition for topical application to the skin, characterized in that the mass ratio [(C) / {(A)+(B)}] of the content of the component (C) to the sum of the contents of the components (A) and (B) is 5.3 or more and 30 or less.

2. the content of the component (A) is 0.2% by mass or more and 0.4% by mass or less relative to the total amount of the liquid composition for topical skin; the content of the component (B) is 0.5% by mass or more and 1.5% by mass or less based on the total amount of the liquid composition for topical skin; The liquid composition for topical skin according to claim 1, wherein the content of the component (C) is 15% by mass or more and 25% by mass or less, based on the total amount of the liquid composition for topical skin.

3. 3. The liquid composition for topical skin according to claim 1, wherein the content of ethyl alcohol in the liquid composition for topical skin is less than 1.0% by mass based on the total amount of the liquid composition for topical skin.

4. The content of the surfactant in the liquid composition for topical skin is less than 1.0% by mass based on the total amount of the liquid composition for topical skin, 4. The liquid composition for external use on skin according to claim 1, wherein the surfactant is at least one selected from an anionic surfactant, a cationic surfactant, and an amphoteric surfactant.

5. 5. The liquid composition for topical skin according to claim 1, wherein the content of purified water in the liquid composition for topical skin is 60% by mass or more based on the total amount of the liquid composition for topical skin.

6. 6. The liquid composition for external use on skin according to claim 1, which is a leave-on type.

7. 7. The liquid composition for external use on skin according to claim 1, which is for use in a mist spray container.

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