Volatile component analyzer and analysis method using the same

Abstract

To provide a volatile component analyzer and analysis method allowing easy and highly sensitive sampling and analysis of a volatile component for objective evaluation of remaining scent after eating or drinking.SOLUTION: A volatile component analyzer includes: a sampling part provided in the middle of a line for supplying carrier gas and having a hollow fiber membrane that can be in contact with an analysis object and through which the carrier gas can pass; a heat desorption device, provided more downstream of the line than the sampling part; a gas chromatograph; and a detector. A flow path switching valve allows switching flow channels between: a flow channel in which the carrier gas leads to the heat desorption device via the sampling part; and a flow channel which the carrier gas leads to the heat desorption device via bypass line without passing through the sampling part.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to an analyzer for volatile components, particularly volatile components as aroma components contained in food and drink, and an analytical method using the same. [Background technology]

[0002] Among volatile compounds, those that can be perceived as aromas are called aroma components. In particular, aroma components contained in foods and beverages are also called flavors, and analyzing and identifying their constituent components and clarifying their aroma composition is essential for flavor development. Furthermore, because aroma components are mixtures of multiple components and are present in trace amounts, many devices and methods have been devised to extract aroma components from the matrix of many foods and beverages.

[0003] In beverages, in addition to proteins, lipids, and carbohydrates, they also contain fruit juice, coloring, emulsifiers, stabilizers, etc. Generally, methods for analyzing aroma components in liquids such as beverages involve a sampling process in which only volatile components are extracted from the beverage matrix, and the obtained volatile components are then subjected to a gas chromatograph, an analytical instrument.

[0004] The sampling process requires large amounts of hazardous organic solvents and involves complex, manual steps, resulting in cumbersome operations. While there are simple methods using robotized headspace extraction to extract only volatile components, or solid-phase microextraction (SPME), these methods are highly robotic and expensive, and simple methods require selectivity for easily and poorly adsorbed volatile components. Therefore, when it comes to simple aroma analysis in fragrance development or aroma analysis for humans, existing devices and methods cannot adequately meet these requirements.

[0005] For example, the device disclosed in Patent Document 1 for monitoring volatile organic compounds in water has a separation unit that uses a silicon hollow fiber membrane to separate volatile organic compounds in a sample into a carrier gas. However, considering the description in Non-Patent Document 1 that hollow fiber silicon membranes are particularly effective in concentrating chlorinated, aromatic, and sulfur compounds, such remarkable selectivity in a sampling device for analyzing volatile components is not appropriate for determining the aroma component composition. Furthermore, Patent Document 1 is a device for monitoring volatile components in water, and the target is water quality standards for tap water, environmental standards for environmental water, and effluent standards for wastewater, which can be said to be water with a higher level of purity than drinking water.

[0006] Furthermore, the online volatile organic analyzer disclosed in Patent Document 2 is merely an online analyzer for volatile organic compounds in gas, and is merely an example of the existing headspace method for aroma analysis.

[0007] In Non-Patent Document 1, hollow fiber silicone membranes were used to investigate the extraction efficiency of volatile organic compounds in liquids, and it was described that the membranes were particularly effective in concentrating chlorinated, aromatic, and sulfur compounds. However, in a sampling device for volatile component analysis, such remarkable selectivity is not appropriate for determining the aroma component composition.

[0008] Furthermore, in Non-Patent Document 2, a regenerated cellulose microdialysis membrane fiber is used to non-selectively introduce volatile components from a liquid into a high-speed gas chromatograph-hydrogen flame ionization detector for analysis. In this device, the volatile components and water sampled by the microdialysis membrane fiber are introduced directly into the high-speed GC, making it unsuitable for using a mass spectrometer as a detector, and in the case of aroma analysis, component identification is difficult.

[0009] Therefore, when developing flavorings, it has been necessary to analyze the aroma components of beverages containing proteins, lipids, carbohydrates, fruit juices, colorings, emulsifiers or stabilizers, etc., and when developing highly palatable foods and beverages, it has been necessary to develop a device and method that can easily and sensitively sample and analyze volatile components, allowing for objective evaluation of the lingering aroma after eating and drinking by analyzing the volatile components mixed with saliva remaining in the mouth after eating and drinking. [Prior art documents] [Patent documents]

[0010] [Patent Document 1] Patent Publication No. 9-304374 [Patent Document 2] Special Table 2014-529080 [Non-patent literature]

[0011] [Non-Patent Document 1] Journal of Environmental Chemistry Vol.5, No.1, pp.73-79, 1995, "Sample introduction and extraction methods using hollow fiber silicone membranes in chromatography" [Non-patent document 2] Analytical chemistry, 80(1), 123-128, “Analysis and monitoring of volatile analytes from aqueous solutions by extractions into the gas phase using microdialysis membranes and coupling to fast GC.” Summary of the Invention [Problem to be solved by the invention]

[0012] Therefore, the present invention aims to overcome the drawbacks of conventional volatile component analyzers and to provide a volatile component analyzer and analysis method that can easily sample and analyze volatile components with high sensitivity, allowing for objective evaluation of lingering aromas after eating or drinking. [Means for solving the problem]

[0013] The present invention solves the above-mentioned problems and provides a volatile component analyzer comprising a sampling section provided midway along a line for supplying carrier gas, the sampling section having a hollow fiber membrane capable of coming into contact with the object to be analyzed and allowing the carrier gas to pass through its interior, and a thermal desorption device, a gas chromatograph, and a detector provided downstream of the sampling section along the line, and configured such that a flow path switching valve can switch the flow path of the carrier gas between a flow path that passes through the sampling section to the thermal desorption device, and a flow path that passes through a bypass line to the thermal desorption device without passing through the sampling section.

[0014] The present invention also provides a volatile component analyzer, wherein the hollow fiber membrane is made of regenerated cellulose.

[0015] The present invention also provides a volatile component analyzer, wherein the hollow fiber membrane is bent into a substantially loop shape.

[0016] The present invention also provides a volatile component analyzer, wherein the gas chromatograph uses a capillary column.

[0017] The present invention also provides a volatile component analyzing apparatus, wherein the detector is a general-purpose detector such as a hydrogen flame ionization detector or a mass spectrometer.

[0018] The present invention also provides a method for analyzing volatile components using the analysis device, comprising: a step of bringing the hollow fiber membrane of the sampling unit into contact with the object to be analyzed, separating volatile components by the hollow fiber membrane as the carrier gas passes through the sampling unit, and guiding the volatile components together with the carrier gas to a thermal desorption device and retaining them in an adsorbent; a step of switching the flow path switching valve to guide the carrier gas to the thermal desorption device via a bypass line without passing through the sampling unit, and removing moisture adsorbed together with the volatile components from the adsorbent; The volatile component analysis method is characterized by including a step of heating the inside of a thermal desorption device, desorbing the volatile components adsorbed on the adsorbent, and analyzing them with an analysis device.

[0019] The present invention also provides a method for analyzing volatile components in food and drink using the above method.

[0020] The present invention further provides a method for analyzing volatile components using the analysis device, comprising: a step of contacting the hollow fiber membrane of the sampling unit with the inside of a human oral cavity, separating volatile components contained in the analyte by the hollow fiber membrane as the carrier gas passes through the sampling unit, and guiding the volatile components together with the carrier gas to a thermal desorption device and retaining them in an adsorbent; a step of switching the flow path switching valve to guide the carrier gas to the thermal desorption device via a bypass line without passing through the sampling unit, and removing moisture adsorbed together with the volatile components from the adsorbent; The volatile component analysis method is characterized by including a step of heating the inside of a thermal desorption device, desorbing the volatile components adsorbed on the adsorbent, and analyzing them with an analysis device. [Effects of the Invention]

[0021] The volatile component analyzer and analytical method of the present invention enable simple and highly sensitive volatile component analysis. In particular, the hollow fiber membrane of the sampling section made of regenerated cellulose enables non-selective sampling of volatile components.

[0022] Furthermore, the volatile component analysis device and analysis method of the present invention are online systems in which the sampling path through which the sample to be analyzed and the carrier gas flow, the thermal desorption device, and the analysis device are physically isolated via hollow fiber membranes, thereby preventing non-volatile components from unintentionally flowing into the thermal desorption device and analysis device.

[0023] Furthermore, the volatile component analysis device and analysis method of the present invention extracts volatile components from the analysis target using a carrier gas, concentrates the volatile components using a thermal desorption device, and removes water, so that a general-purpose capillary gas chromatograph can be used as the analysis device and a mass spectrometer can be used as the detector.

[0024] Furthermore, the volatile component analyzer and analytical method of the present invention do not require the conventional complicated pretreatment using organic solvents, etc., and are simple and convenient, as they only require the hollow fiber membrane of the sampling section to come into contact with the subject to be analyzed.

[0025] Furthermore, the volatile component analysis device and analysis method of the present invention are capable of sampling, concentrating, and analyzing volatile components simply by contacting them with the subject of analysis, and therefore, by contacting them with the human oral cavity, it is possible to analyze volatile components mixed with saliva. [Brief explanation of the drawings]

[0026] [Figure 1] 1 is a diagram showing a schematic configuration of a volatile component analyzer according to the present invention; [Figure 2] 1 is a diagram showing a schematic configuration of a volatile component analyzer according to the present invention; [Figure 3] FIG. 1 is a diagram showing an embodiment of a hollow fiber membrane of a volatile component analyzer according to the present invention. [Figure 4] Graph showing the analysis results of volatile components of Example Product 1 in Test Example 1 and the analysis results of direct analysis of fragrance. [Figure 5] Graph showing the analysis results of volatile components of Comparative Product 1 in Test Example 1 and the analysis results of direct analysis of fragrance. [Figure 6] Graph showing the analysis results of volatile components of Comparative Product 2 in Test Example 1 and the analysis results of direct analysis of fragrance. [Figure 7] 10 is a graph showing the quantitative analysis results of the volatile component analyzer in Test Example 2. [Figure 8] A graph plotting the peak area values ​​of components 1 to 4 shown in Figure 7 versus sampling time. [Figure 9] 10 is a graph showing the analysis results of moisture removal purge in Test Example 3. [Figure 10] 10 is a graph showing the analysis results of moisture removal purge in Test Example 3. [Figure 11] Graph showing the analysis results of volatile components of residues in the oral cavity in Test Example 4. DETAILED DESCRIPTION OF THE INVENTION

[0027] Hereinafter, embodiments of the volatile component analyzer of the present invention will be specifically described with reference to the drawings, although the present invention is not limited to these embodiments.

[0028] 1 is a diagram showing a schematic configuration of a volatile component analyzer according to the present invention. As shown in the figure, the volatile component analyzer according to the present invention comprises a sampling unit 1 provided midway along a line 7 for supplying a carrier gas, a thermal desorption device 3 provided downstream of the sampling unit 1 on the line 7, a gas chromatograph 4, and a detector 5. The sampling unit 1 is connected to a flow path switching valve 2, which is configured so that the flow path of the carrier gas can be switched to a bypass line 8 that does not pass through the sampling unit 1. Each unit will be described in detail below.

[0029] The sampling unit 1 includes a hollow fiber membrane 11 through which a carrier gas can pass and on the surface of which a sample to be analyzed can come into contact. Lines 7b and 7c, which serve as carrier gas flow paths, are connected to both ends of the hollow fiber membrane 11. A regenerated cellulose material can be suitably used as the material for the hollow fiber membrane 11. Using regenerated cellulose as the material for the hollow fiber membrane 11 is thus preferable because it enables non-selective sampling of volatile components.

[0030] The hollow fiber membrane 11 is preferably bent as a whole into a generally loop shape as shown in Fig. 3 so that it can be easily inserted into the oral cavity and placed on the tongue within the oral cavity. Furthermore, to increase the surface area relative to the volume within the hollow fiber membrane and enable efficient sampling relative to the amount of carrier gas, the hollow fiber membrane preferably has an inner diameter of 0.05 mm to 0.8 mm, and more preferably an inner diameter of 0.1 mm to 0.4 mm. Furthermore, while the longer the hollow fiber membrane 11, the higher the sampling efficiency, and the more preferable is a total length of 100 mm to 150 mm, which does not impair workability within the oral cavity and allows placement on the tongue.

[0031] The thermal desorption device 3 is filled with an adsorbent 31 and captures volatile components contained in the carrier gas passing through the inside. The adsorbent 31 that has captured the volatile components can be heated to desorb the adsorbed volatile components.

[0032] A gas chromatograph 4 is connected downstream of the thermal desorption device 3. A general-purpose gas chromatograph equipped with a capillary column 41 can be used as the gas chromatograph 4. Furthermore, a general-purpose detector such as a flame ionization detector (FID) or a mass spectrometer (MS) can be used as the detector 5 as appropriate.

[0033] A typical six-port, two-position six-way valve can be used as the flow path switching valve 2. A line 7a, the other end of which is connected to the carrier gas supply unit 7, is connected to port 21 of the flow path switching valve 2, and lines 7b and 7c, the other ends of which are connected to ends of the hollow fiber membranes 11, are connected to ports 22 and 23, respectively. A line 7d, the other end of which is connected to the thermal desorption device 3, is connected to port 24. Both ends of a bypass line 8 are connected to ports 25 and 26.

[0034] When the flow path switching valve 2 is set to the position shown in Figure 1, the carrier gas flows through the sampling unit 1 to the thermal desorption device 3. On the other hand, when it is set to the position shown in Figure 2, the flow path of the carrier gas switches to the bypass line 8, and the carrier gas flows to the thermal desorption device 3 without passing through the sampling unit 1.

[0035] The analytical steps using the volatile component analyzer of the present invention are as follows. <Process 1> The surface of the hollow fiber membrane 11 of the sampling unit 1 is brought into contact with the object to be analyzed, and carrier gas is supplied from the carrier gas supply unit 6 to the sampling unit 1 via lines 7a and 7b. As the carrier gas passes through the hollow fiber membrane 11 of the sampling unit 1, the volatile components contained in the object to be analyzed are separated by the hollow fiber membrane 11 and led to the thermal desorption device 3 together with the carrier gas, where they are retained in the adsorbent 31.

[0036] <Process 2> The flow path switching valve 2 is switched to stop sampling, and the carrier gas is led to the thermal desorption device 3 via the bypass line 8 without passing through the sampling section 1, and the moisture adsorbed together with the volatile components is removed from the adsorbent 31.

[0037] <Process 3> The interior of the thermal desorption device 3 is heated to desorb the volatile components adsorbed to the adsorbent 31, and the desorbed components are analyzed by an analyzer, and data is collected and processed.

[0038] The analysis target of the volatile component analyzer and analysis method according to the present invention may be not only a liquid such as a beverage, but also a solid or sol-gel food product. If the analysis target is a liquid, the hollow fiber membrane 11 can be immersed in the liquid in step 1. If the analysis target is a solid or sol-gel, the front side of the hollow fiber membrane 11 can be brought into contact with the surface of the target or can be embedded in the target, depending on the physical properties of the target.

[0039] Furthermore, when analyzing volatile components in the human oral cavity using the volatile component analyzer and analytical method of the present invention, the hollow fiber membrane 11 is partially or entirely inserted into the oral cavity and the front side of the hollow fiber membrane 11 is brought into contact with the oral cavity, for example, the tongue, in step 1. By bringing the hollow fiber membrane 11 into contact with the oral cavity after or during eating or drinking, volatile components in the oral cavity can be analyzed.

[0040] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples in any way. [Example]

[0041] Test example 1: Evaluation of characteristics using different hollow fiber membrane materials Example 1 and comparative products 1 and 2 were prepared using the following method. Volatile components were collected and analyzed using these, and compared with the volatile components observed during direct analysis of fragrances.

[0042] <Manufacturing method> Implemented product 1: The sampling unit of the volatile component analyzer of the present invention was prepared as follows. Both ends of a hollow fiber dialysis membrane (Spectra / Por® In Vivo Microdialysis Hollow Fibers, MWCO: 13 kD) made of regenerated cellulose were inserted 5 mm into one end of a deactivated fused silica capillary, and epoxy resin was applied to the joint. The capillary was then left to stand at room temperature for 24 hours to harden. Then, a deactivated stainless steel tube was connected to the remaining end of the capillary via an adapter.

[0043] Pineapple flavoring was added to distilled water at 0.1% (w / w), and the hollow fiber membrane of the sampling device was contacted with the sample. The temperature of the adsorbent-containing glass liner of the thermal desorption device was set to 20°C, the gas chromatograph inlet pressure was set to 75 kPa, and the six-way valve was held in the position shown in Figure 1 for 5 minutes. With the hollow fiber membrane in contact with the distilled water, He carrier gas was introduced through the carrier gas supply, and the volatile components were collected in the thermal desorption device. The six-way valve was then switched to the position shown in Figure 2, and analysis was performed under the following conditions. The results are shown in Figure 4. [Analysis conditions] Thermal desorption device ·Initial temperature: 20℃ Heating conditions: 12°C per second, maintain 240°C for 10 minutes gas chromatograph Inlet: Solvent vent mode He carrier gas flow rate: 1.8 mL / min Oven: Initial temperature is 50°C, then hold for 5 minutes, then increase the temperature by 5°C per minute, and hold after reaching 220°C Column: DB-WAX, length 60m, inner diameter 0.25, film thickness 250μm (J&W) Detector: FID

[0044] In order to compare with the analysis results obtained by the volatile component analyzer of the present invention, the injection port temperature of the gas chromatograph was set to 250°C, 0.2 μL of fragrance was taken using a microsyringe and introduced into the injection port in split mode (split ratio 10:1), and the fragrance was directly analyzed under the following conditions. [Analysis conditions] He carrier gas flow rate: 1.8 mL / min Oven: Initial temperature is 50°C, then hold for 5 minutes, then increase the temperature by 5°C per minute, and hold after reaching 220°C Column: DB-WAX, length 60 m, inner diameter 0.25 mm, film thickness 250 μm (J&W) Detector: FID

[0045] Compared to direct analysis of flavorings, analysis of Product 1 using the volatile component analyzer showed a similar balance of volatile components from 5 to 30 minutes on the chromatogram shown in Figure 4. Furthermore, ethanol, ethyl maltol, and glycerin, which are observed in direct analysis of flavorings, are highly hydrophilic components, and are volatile components that are difficult to recover even with conventional solvent extraction methods. Thus, the volatile component analyzer of the present invention made it possible to easily analyze the aroma components of beverages.

[0046] Comparison 1: A hollow fiber membrane made of cellulose triacetate removed from an FB-210EGeco hollow fiber dialyzer (Nipro Corporation) and cut to a length of 15.24 cm was used as the hollow fiber membrane for the sampling part, and the sampling part was prepared in the same manner as in Example 1. This sampling part was used and analyzed under the same conditions as in Example 1. The results are shown in Figure 5.

[0047] As is clear from Figure 5, the sampling device using a hollow fiber membrane made of cellulose triacetate, a cellulose-based material, captured almost no aroma components.

[0048] Comparison 2: The hollow fiber membrane in the sampling section was a hollow fiber membrane made of synthetic polymer polyethersulfone taken from a PES-21Mαeco hollow fiber dialyzer (Nipro Corporation) and cut to a length of 15.24 cm, and the sampling section was prepared in the same manner as in Example 1. This sampling section was used for analysis under the same conditions as in Example 1. The results are shown in Figure 6.

[0049] As shown in Figure 6, the sampling device using a hollow fiber membrane made of polyethersulfone, a synthetic polymer, captured aroma compounds. However, the balance of volatile compounds between 5 and 30 minutes on the chromatogram is not similar to that observed during direct analysis of fragrances.

[0050] Test Example 2: Quantitative performance of volatile component analyzer Based on the analytical conditions of Test Example 1, the hollow fiber membrane of the sampling device for Example 1 was contacted with a strawberry-flavored dairy lactic acid bacteria beverage for 5 minutes, 2 minutes 30 seconds, 1 minute 15 seconds, or 37.5 seconds, and the results of analyzing the volatile components are shown in Figures 7 and 8.

[0051] The chromatogram shown in Figure 7 indicates a correlation between the detected amount of components represented by components 1, 2, 3, and 4 and the sampling time. As shown in Figure 8, which plots the peak area values ​​of 1 to 4 versus the sampling time, the linearity was particularly good between the sampling times of 37.5 seconds and 2 minutes and 50 seconds.

[0052] Test Example 3: Water removal using a thermal desorption device in the analysis of volatile components in beverages The hollow fiber membrane in the sampling section of Example 1 was contacted with a strawberry-flavored dairy lactic acid bacteria beverage, the temperature of the adsorbent-containing glass liner of the thermal desorption device was set to 60°C, 40°C, or 20°C, the inlet pressure of the gas chromatograph-mass spectrometer was set to 75 kPa, and the six-way valve was held in the position shown in Figure 1 for 5 minutes, and the volatile components were collected in the thermal desorption device. The six-way valve was then switched to the position shown in Figure 2, and a moisture removal purge was performed using helium carrier gas, and the analysis was performed under the following conditions. The results are shown in Figure 9. [Analysis conditions] Thermal desorption device Initial temperature: 60℃, 40℃ or 20℃ Moisture removal purge time: 5 minutes Heating conditions: 12°C per second, maintain 240°C for 10 minutes gas chromatograph Inlet: Solvent vent mode He carrier gas flow rate: 1.8 mL / min Oven: Initial temperature 40°C, increase temperature by 5°C per minute, and maintain at 220°C Column: TC-FFAP, length 30 m, inner diameter 0.25 mm, film thickness 250 μm (GL Sciences) Detector: 5973MSD, SIM / Scan mode, SIM: m / z = 18, Scan: m / z = 35 to 350

[0053] As shown in Figure 9, when moisture removal was not performed, a water peak was observed at the top of the SIM chromatogram for m / z = 18, with retention times ranging from 2 to 4 minutes. However, after a 5-minute moisture removal purge using helium carrier gas was performed, the water peak at retention times ranging from 2 to 4 minutes disappeared in the second, third, and fourth SIM chromatograms.

[0054] Furthermore, as shown in Figure 10, when the initial temperature of the thermal desorption apparatus was set to 40°C or 20°C, the ethyl butanoate, which is reduced by a 5-minute moisture removal purge using helium carrier gas at 60°C, was maintained at 40°C or 20°C. Furthermore, when the initial temperature of the thermal desorption apparatus was set to 20°C, it became possible to detect ethyl acetate, which has a boiling point of 77.1°C and was not visible when the initial temperature was 60°C or 40°C.

[0055] Test Example 4: Analysis of volatile components of residues in the oral cavity Based on the analytical conditions of Test Example 1, the hollow fiber membrane of the sampling device was placed in contact with the oral cavity for 5 minutes or 1 minute after consuming a strawberry-flavored dairy lactic acid bacteria beverage, and the volatile components were analyzed. The chromatograms are shown in Figure 11. Even with a 1-minute sampling time in the oral cavity, components 1, 2, 3, and 4 were detected on the chromatogram. Furthermore, of the volatile components remaining in the oral cavity, component 3 (Z)-3-hexenol and component 4 (linalool), which have lower vapor pressures than component 1 (methyl butanoate) and component 2 (methyl hexanoate), were more likely to remain.

[0056] As described above, measuring residues in the mouth using an online volatile component analyzer is useful for objectively evaluating the lingering aroma after eating and drinking, leading to the development of foods and beverages with high palatability. [Industrial Applicability]

[0057] The volatile component analyzer and analysis method of the present invention can be used not only to analyze volatile components contained in food and drink, but also to analyze other volatile components, such as volatile components contained in mouthwash. [Explanation of symbols]

[0058] 1 ... Sampling section 2 … … Stream switching valve 3. Thermal desorption device 4... Gas chromatograph 5 … … detector 6 … … Carrier gas supply section 7a … … line 7b … … line 7c … … line 7d … … line 8 … … Bypass line 11 ... ... Hollow fiber membrane 21 … … Port 22 … … port 23 … … Port 24 … … ports 25 … … Port 26 … … Port 31 ... ... adsorbent 41 … … Capillary column

Claims

1. A volatile component analyzer comprising: a sampling unit provided midway along a line for supplying carrier gas, the sampling unit having a hollow fiber membrane capable of contacting an object to be analyzed and allowing the carrier gas to pass through its interior; and a thermal desorption device, a gas chromatograph, and a detector provided downstream of the sampling unit along the line; and a flow path switching valve configured to switch the flow path of the carrier gas between a flow path that passes through the sampling unit to the thermal desorption device, and a flow path that passes through a bypass line to the thermal desorption device without passing through the sampling unit.

2. 2. The volatile component analyzer according to claim 1, wherein the hollow fiber membrane is made of regenerated cellulose.

3. 3. The volatile component analyzer according to claim 1, wherein the hollow fiber membrane is bent into a substantially loop shape.

4. 4. The volatile component analyzer according to claim 1, wherein the gas chromatograph uses a capillary column.

5. 5. The volatile component analyzer according to claim 1, wherein the detector is a general-purpose detector such as a flame ionization detector or a mass spectrometer.

6. A method for analyzing volatile components using the analysis device according to any one of claims 1 to 5, comprising: a step of bringing the hollow fiber membrane of the sampling unit into contact with the analyte, separating volatile components contained in the analyte by the hollow fiber membrane as the carrier gas passes through the sampling unit, and guiding the volatile components together with the carrier gas to a thermal desorption device and retaining them in an adsorbent; a step of switching the flow path switching valve to guide the carrier gas to the thermal desorption device via a bypass line without passing through the sampling unit, and removing moisture adsorbed together with the volatile components from the adsorbent; A method for analyzing volatile components, comprising the steps of heating the interior of a thermal desorption device, desorbing volatile components adsorbed on an adsorbent, and analyzing the desorbed volatile components with an analytical device.

7. A method for analyzing volatile components of food and drink, using the method according to claim 6.

8. A method for analyzing volatile components using the analysis device according to any one of claims 1 to 5, comprising: a step of contacting the hollow fiber membrane of the sampling unit with the inside of a human oral cavity, separating volatile components contained in the analyte by the hollow fiber membrane as the carrier gas passes through the sampling unit, and guiding the volatile components together with the carrier gas to a thermal desorption device and retaining them in an adsorbent; a step of switching the flow path switching valve to guide the carrier gas to the thermal desorption device via a bypass line without passing through the sampling unit, and removing moisture adsorbed together with the volatile components from the adsorbent; A method for analyzing volatile components, comprising the steps of heating the interior of a thermal desorption device, desorbing volatile components adsorbed on an adsorbent, and analyzing the desorbed volatile components with an analytical device.

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