Dialysis effluent component measuring device and method

Abstract

To provide a device and a method for component measurement for dialysis drainage capable of accurately measuring concentration of a component to be measured in dialysis drainage.SOLUTION: A component to be measured is excited by light of a first wavelength and emits fluorescent light of a second wavelength, and dialysis drainage includes a measurement inhibition component excited by the light of the first wavelength and emitting fluorescent light including the second wavelength. A device 1 for component measurement for dialysis drainage includes: a light source 2 for irradiating dialysis drainage with light of a first wavelength; a scattered light measurement unit 3 for receiving scattered light of a first wavelength scattered by the dialysis drainage at a plurality of angles, and measuring the light intensity of the scattered light; a fluorescent light measurement unit 4 for measuring the light intensity of fluorescent light of the second wavelength; a ratio calculation unit 51 for calculating a ratio of the concentration of the component to be measured contained in the dialysis drainage to the concentration of the measurement inhibition component on the basis of a result of the measurement by the scattered light measurement unit 3; and a component-to-be-measured concentration calculation unit 52 for calculating the concentration of the component to be measured in the dialysis drainage on the basis of the ratio of the concentration calculated by the ratio calculation unit 51 and the light intensity of the fluorescent light measured by the fluorescent light measurement unit 4.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to an apparatus and method for measuring components in a dialysis effluent. [Background technology]

[0002] In a blood purification device, blood is purified by contacting the blood with the dialysate through a blood purification membrane in a blood purifier (also called a dialyzer). If certain components in the blood leak too much into the dialysate, complications and other problems may occur. Therefore, to avoid such problems, it is desirable to monitor the concentrations of certain components in the dialysis effluent discharged from the blood purifier.

[0003] An example of a component (referred to as a component to be measured) in dialysis effluent that is desired to be monitored is albumin. Patent Document 1 discloses a method for measuring the concentration of albumin by optically exciting albumin in the solution and measuring the emitted fluorescence. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Special Publication No. 2014-518517 Summary of the Invention [Problem to be solved by the invention]

[0005] However, dialysis effluent contains various substances other than the component to be measured, and the concentration of the component to be measured may be inhibited by other substances, making it difficult to obtain the concentration of the component to be measured with sufficient accuracy. Specifically, when measuring the concentration of albumin by fluorescence as in Patent Document 1, it is difficult to distinguish it from large molecular weight filtrate toxins such as β2-microglobulin contained in the dialysis effluent, making it difficult to measure the concentration of albumin, the component to be measured, with sufficient accuracy.

[0006] Therefore, an object of the present invention is to provide a dialysis effluent component measuring device and method that can accurately measure the concentration of a target component in a dialysis effluent. [Means for solving the problem]

[0007] A dialysis effluent component measuring device according to one embodiment of the present invention is a device for measuring the concentration of a metered component contained in dialysis effluent discharged from a blood purifier, wherein the metered component is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, and the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength, and the device comprises: a light source that irradiates the dialysis effluent with light of the first wavelength; a scattered light measuring unit that receives scattered light of the first wavelength scattered by the dialysis effluent at multiple angles and measures the light intensity of the scattered light; a fluorescence measuring unit that measures the light intensity of the fluorescence of the second wavelength; a ratio calculating unit that calculates the ratio of the concentration of the metered component to the concentration of the measurement-inhibiting component contained in the dialysis effluent based on the measurement result of the scattered light measuring unit; and a metered component concentration calculating unit that calculates the concentration of the metered component in the dialysis effluent based on the concentration ratio calculated by the ratio calculating unit and the light intensity of the fluorescence measured by the fluorescence measuring unit.

[0008] Furthermore, a dialysis effluent component measurement method according to one embodiment of the present invention is a method for measuring the concentration of a metered component contained in dialysis effluent discharged from a blood purifier, wherein the metered component is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, and the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength, the method irradiating the dialysis effluent with light of the first wavelength from a light source, receiving the scattered light of the first wavelength scattered by the dialysis effluent at multiple angles, and measuring the light intensity of the fluorescence of the second wavelength, and calculating the ratio between the concentration of the metered component contained in the dialysis effluent and the concentration of the measurement-inhibiting component based on the measurement result of the light intensity of the scattered light, and calculating the concentration of the metered component in the dialysis effluent based on the calculated concentration ratio and the measured light intensity of the fluorescence. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide a dialysis effluent component measuring device and method that can accurately measure the concentration of a component to be measured in a dialysis effluent. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a schematic diagram illustrating the configuration of a blood purification device using a dialysis effluent component measuring device according to one embodiment of the present invention. [Figure 2] 1 is a schematic diagram of a dialysis effluent component measuring device according to one embodiment of the present invention. FIG. [Figure 3] FIG. 10(a) is an explanatory diagram illustrating a scattered light measurement unit, and FIG. 10(b) is an explanatory diagram illustrating a modified example of the scattered light measurement unit. [Figure 4] FIG. 1 is a flow diagram of a method for measuring components in a dialysis effluent according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0011] [Embodiment Mode] Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings.

[0012] (blood purification device) First, a blood purification apparatus using the dialysis effluent component measuring device according to the present embodiment will be described. Fig. 1 is a schematic diagram of a blood purification apparatus using the dialysis effluent component measuring device according to the present embodiment.

[0013] As shown in Fig. 1, a blood purification device 10 includes a blood circuit 11 for extracorporeally circulating a patient's blood, a liquid supply flow path 13 for supplying a supply liquid to a blood purifier 12 provided in the blood circuit 11, and a drainage flow path 14 for discharging drainage liquid from the blood purifier 12. In the example of Fig. 1, the liquid supply flow path 13 is shown as a dialysate flow path 13a for supplying dialysate to the blood purifier 12. However, the liquid supply flow path 13 is not limited to this, and may be a substitution fluid flow path for directly supplying substitution fluid to the blood circuit 11, or may have both the dialysate flow path 13a and a substitution fluid flow path.

[0014] The blood circuit 11 is composed of, for example, flexible tubes. In the blood circuit 11, a blood pump 111, a blood purifier 12, and an air trap chamber 112 are sequentially provided from the upstream side to the downstream side of the blood flow. The blood pump 111 is a liquid delivery pump that delivers blood. The air trap chamber 112 is used to remove air bubbles from the blood.

[0015] Dialysis water is supplied to the dialysate flow path 13a from an RO device (not shown) that produces clean dialysis water using a reverse osmosis (RO) membrane. Two types of dialysis solution stock solutions, stock solution A and stock solution B, are also supplied to the dialysate flow path 13a. Both stock solutions are stored in stock solution storage tanks 151, and stock solution A and stock solution B are supplied from the stock solution storage tanks 151 to the dialysate flow path 13a via stock solution flow paths 152. Each of the stock solution flow paths 152 is provided with a stock solution injection pump 153, which is a liquid feed pump that feeds stock solution A or stock solution B. Dialysis water is prepared in the dialysate flow path 13a by mixing stock solution A and stock solution B. The prepared dialysis solution is introduced into the blood purifier 12 via a duplex pump 16. However, the blood purification device 10 is not limited to this, and may be configured to supply a prepared dialysis solution stock solution, for example, a mixture of stock solutions A and B. Alternatively, the mechanism for preparing dialysis solution from dialysis water and dialysis solution stock solution may be omitted, and the dialysis solution may be supplied from an external source. In other words, the blood purification device 10 may be a personal dialysis device having a mechanism for preparing dialysis solution from dialysis water and dialysis solution stock solution, or a dialysis monitoring device supplied with dialysis solution from a multi-person dialysis solution supply device.

[0016] The dialysis effluent discharged from the blood purifier 12 is discharged through the drainage flow path 14. The duplex pump 16 is provided across the dialysate flow path 13a and the drainage flow path 14, and performs pumping operation so that the amount of dialysate introduced into the blood purifier 12 is equal to the amount of effluent discharged from the blood purifier 12. The drainage flow path 14 is also provided with a water removal flow path 14a that bypasses the duplex pump 16, and this water removal flow path 14a is provided with a water removal pump 17. When the water removal pump 17 is driven, the amount of effluent discharged from the blood purifier 12 becomes greater than the amount of dialysate introduced into the blood purifier 12, thereby removing water from the blood. The amount of water removed from the blood can be adjusted by adjusting the amount of fluid sent by the water removal pump 17.

[0017] A dialysis effluent component measuring device 1 according to this embodiment is provided in a drainage flow path 14 of a blood purification apparatus 10. The dialysis effluent component measuring device 1 is provided in the drainage flow path 14 downstream of the position where the water removal flow path 14a joins the drainage flow path 14. Note that the configuration in Fig. 1 is merely an example, and the specific configuration of the blood purification apparatus 10 can be changed as appropriate.

[0018] (Dialysis effluent component measuring device 1) 2 is a schematic diagram of the dialysis effluent component measuring device 1 according to this embodiment. The dialysis effluent component measuring device 1 is a device that measures the concentration of a specific target component contained in the dialysis effluent discharged from a blood purifier 12.

[0019] The component to be measured is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength. In this embodiment, a case where the component to be measured is albumin will be described. That is, the dialysis effluent component measuring device 1 is, for example, a device that measures the concentration of albumin in dialysis effluent. When the component to be measured is albumin, the first wavelength, which is the wavelength of the excitation light, is 250 nm or more and 330 nm or less, more preferably 275 nm or more and 285 nm or less. The second wavelength, which is the wavelength of the fluorescence emitted by albumin, is 300 nm or more and 400 nm or less.

[0020] Furthermore, the dialysis effluent contains a measurement-inhibiting component that is excited by light of a first wavelength and emits fluorescence including a second wavelength. That is, the dialysis effluent contains a measurement-inhibiting component that is excited by excitation light that excites albumin and emits fluorescence of the same wavelength as albumin. Due to the influence of this measurement-inhibiting component, it is difficult to accurately measure the albumin concentration using fluorescence alone. Here, as an example, a case where the measurement-inhibiting component is β2-microglobulin (β2-MG) will be described. Note that the measurement-inhibiting component is not limited to β2-microglobulin as long as it corresponds to the component to be measured. Furthermore, two or more measurement-inhibiting components may be contained in the dialysis effluent.

[0021] As shown in Fig. 2, the dialysis effluent component measuring device 1 mainly comprises a light source 2, a scattered light measuring unit 3, a fluorescence measuring unit 4, and a computing device 5. The light source 2 irradiates the dialysis effluent with light of a first wavelength capable of exciting albumin, the component to be measured. Here, a light emitting diode that irradiates ultraviolet light with a wavelength of 280 nm was used as the light source 2.

[0022] The drainage flow path 14 is provided with a flat, thin measuring section 14b so that the flow path has a substantially uniform thickness. Here, the measuring section 14b is formed to have a substantially elliptical shape when viewed from the light source 2 side. The light source 2 is provided so as to face the center of the measuring section 14b in the thickness direction of the measuring section 14b. The measuring section 14b is made of a material that transmits light of at least the first and second wavelengths (having sufficiently high transmittance for the first and second wavelengths). In addition, a lens 6 is provided between the light source 2 and the measuring section 14b. The light emitted from the light source 2 is focused by the lens 6 and enters the measuring section 14b. Here, the light from the light source 2 is converted by the lens 6 into parallel light which enters the measuring section 14b.

[0023] The scattered light measurement unit 3 receives scattered light of a first wavelength (i.e., the same wavelength as the light source 2) at multiple angles, resulting from light incident on the measurement unit 14b being scattered by the dialysis effluent, and measures the intensity of the scattered light. The scattered light measurement unit 3 has multiple scattered light photodetectors (PDs) 31 arranged at different scattering angles. Although not shown, a filter that blocks light of the second wavelength and passes light of the first wavelength may be provided between each scattered light photodetector 31 and the measurement unit 14b. In this case, a bandpass filter that passes light of the emission wavelength of the light source 2 is preferably used as the filter, and is preferably configured to pass light with a wavelength of 250 nm to 330 nm, more preferably 275 nm to 285 nm.

[0024] The molecular weight of the measured component, albumin, is approximately 66 KDa, while the molecular weight of the measurement-inhibiting component, β2-microglobulin, is approximately 12 KDa. Albumin and β2-microglobulin therefore have different molecular weights. Therefore, by utilizing the difference in scattering patterns resulting from this difference in molecular weight, it is possible to distinguish between albumin and β2-microglobulin.

[0025] In this embodiment, a scattering pattern due to albumin and a scattering pattern due to β2-microglobulin were obtained in advance by experiments, etc. Then, with reference to both scattering patterns obtained by experiments, etc., one or more first PDs 31a were placed at a scattering angle that is less affected by β2-microglobulin and more affected by albumin (i.e., a scattering angle at which the light intensity of the scattered light due to β2-microglobulin is low and the light intensity of the scattered light due to albumin is high). Furthermore, with reference to both scattering patterns obtained by experiments, etc., one or more second PDs 31b were placed at a scattering angle that is more affected by β2-microglobulin and less affected by albumin (i.e., a scattering angle at which the light intensity of the scattered light due to β2-microglobulin is high and the light intensity of the scattered light due to albumin is low).

[0026] 3(a), the light intensity of the scattered light received by the first PD 31a is less affected by β2-microglobulin, and the light intensity of the scattered light received by the second PD 31b is less affected by albumin. Therefore, by comparing the light intensity received by the first PD 31a and the light intensity received by the second PD 31b, it is possible to determine the concentration ratio of albumin to β2-microglobulin. The ratio of the concentrations of albumin to β2-microglobulin is calculated by a ratio calculation unit 51, which will be described later.

[0027] 3(b), for example, the scattered light measuring unit 3 may be configured so that scattered light receiving elements 31 are arranged at each predetermined scattering angle and a scattering pattern is determined from the light intensity of the scattered light received by all of the scattered light receiving elements 31. In this case, the ratio calculation unit 51 determines the ratio of the concentrations of albumin and β2-microglobulin by analyzing the obtained scattering pattern, i.e., the scattering pattern in which the effects of albumin and β2-microglobulin are superimposed.

[0028] The fluorescence measurement unit 4 measures the intensity of fluorescence of a second wavelength generated when light of a first wavelength is irradiated onto the measurement unit 14b. The fluorescence measurement unit 4 includes a fluorescence photodetector (PD) 41, a bandpass filter 42 that blocks light of the first wavelength from entering the fluorescence photodetector 41 and transmits light of the second wavelength, and a lens 43 that serves as a light-guiding member that guides fluorescence generated in the dialysis effluent (i.e., generated in the measurement unit 14b) to the fluorescence photodetector 41. The bandpass filter 42 is disposed between the measurement unit 14b and the fluorescence photodetector 41 and blocks light of the first wavelength (transmitted light and scattered light) while passing only light of the second wavelength due to fluorescence. The wavelength that the bandpass filter 42 passes is preferably 300 nm or more and 400 nm or less, the same as the second wavelength, and more preferably a wavelength range around 340 nm, the fluorescence wavelength of albumin (e.g., 330 nm or more and 350 nm or less). Since the light intensity of fluorescence is relatively low, in this embodiment, light collected by lens 43 is received by fluorescence light receiving element 41. Lens 43 is provided between measurement unit 14b and bandpass filter 42.

[0029] The calculation device 5 is equipped with a ratio calculation section 51, a metered component concentration calculation section 52, a metered component leakage amount calculation section 53, an alarm section 54, and a memory section 55. The ratio calculation section 51, the metered component concentration calculation section 52, the metered component leakage amount calculation section 53, and the alarm section 54 are realized by appropriately combining a calculation element, a memory, software, an interface, a storage device such as a hard disk, etc. The memory section 55 is realized using a predetermined storage area in the memory or storage device. The calculation device 5 may be, for example, a control device of the blood purification apparatus 10.

[0030] The ratio calculation unit 51 calculates the ratio between the concentration of the measurement target component (here, albumin) contained in the dialysis effluent and the concentration of the measurement-inhibiting component (here, β2-microglobulin) based on the measurement results of the scattered light measurement unit 3. As described in Fig. 3(a), in this embodiment, the ratio between the concentrations of albumin and β2-microglobulin is calculated by comparing the light intensity received by the first PD 31a and the light intensity received by the second PD 31b (for example, by calculating the ratio of the light intensities).

[0031] As described with reference to FIG. 3(b), when a scattering pattern is measured by the scattered light measurement unit 3, the ratio calculation unit 51 analyzes the measured scattering pattern to determine the ratio of albumin and β2-microglobulin concentrations. In this case, the ratio calculation unit 51 performs machine learning in advance using a plurality of scattering patterns with different albumin and β2-microglobulin concentrations, and learns the association between the scattering pattern (e.g., the received intensity of scattered light at a specific scattering angle) and the albumin and β2-microglobulin concentrations. Then, based on the trained model that is the result of the learning, the ratio calculation unit 51 estimates the albumin and β2-microglobulin concentrations from the scattering pattern and determines the ratio of albumin and β2-microglobulin concentrations. The learning algorithm used for machine learning is not particularly limited, and any known learning algorithm can be used. For example, so-called deep learning, which uses a neural network with three or more layers, can be used.

[0032] The analyte concentration calculation unit 52 calculates the concentration of the analyte (here, albumin) in the dialysis effluent based on the ratio of the albumin and β2-microglobulin concentrations calculated by the ratio calculation unit 51 and the fluorescent light intensity measured by the fluorescence measurement unit 4. The fluorescent light intensity measured by the fluorescence measurement unit 4 is affected by both albumin and β2-microglobulin. Therefore, by taking into account the ratio of the albumin and β2-microglobulin concentrations, it is possible to calculate the albumin concentration while isolating only the effect of albumin.

[0033] The measurement component leakage amount calculation unit 53 calculates the leakage amount of the measurement component since the start of treatment based on the concentration of the measurement component (here, albumin) calculated by the measurement component concentration calculation unit 52 and the flow rate of the dialysis effluent. The flow rate of the dialysis effluent may be calculated from the drive amount of the duplex pump 16 and the ultrafiltration pump 17, or may be measured by providing a flow rate sensor in the drainage flow path 14.

[0034] More specifically, measurement component leakage amount calculation unit 53 calculates the average albumin concentration for one minute, and multiplies the average albumin concentration by the flow rate of the dialysis effluent to calculate the albumin leakage amount per minute, and stores this amount for each minute in memory unit 55. Then, by adding up all the albumin leakage amounts per minute stored in memory unit 55 for the entire elapsed treatment time, the leakage amount of the measurement component from the start of treatment is calculated.

[0035] When the albumin concentration calculated by analyte concentration calculation unit 52 is equal to or greater than a preset threshold, alarm unit 54 issues an alarm by appropriate means such as light, sound, or display. In this embodiment, when the amount of albumin leakage calculated by analyte leakage amount calculation unit 53 is equal to or greater than a preset threshold, alarm unit 54 issues an alarm by appropriate means such as light, sound, or display.

[0036] (Method for measuring components in dialysis effluent) 4 is a flow diagram of the method for measuring components in a dialysis effluent according to this embodiment. For example, the flow of FIG. 4 starts at the start of blood purification treatment.

[0037] As shown in FIG. 4, in the method for measuring components in dialysis effluent according to this embodiment, first, in step S1, light of a first wavelength (here, wavelength 280 nm) is irradiated onto the dialysis effluent from the light source 2, and in step S2, the scattered light is received at multiple angles by the scattered light receiving elements 31 (first PD 31a and second PD 31b) of the scattered light measuring unit 3 to measure the light intensity, and the fluorescence light receiving element 41 of the fluorescence measuring unit 4 measures the light intensity of fluorescence of a second wavelength (here, 340 nm).

[0038] Thereafter, in step S3, the ratio calculation unit 51 calculates the ratio between the concentration of the measurement target component (here, albumin) contained in the dialysis effluent and the concentration of the measurement-inhibiting component (here, β2-microglobulin) based on the measurement result of the scattered light measurement unit 3. In this embodiment, the ratio calculation unit 51 calculates the ratio between the concentrations of albumin and β2-microglobulin by comparing the light reception intensity at the first PD 31a and the light reception intensity at the second PD 31b.

[0039] Thereafter, in step S4, the measurement component concentration calculation unit 52 calculates the concentration of the measurement component (here, albumin) in the dialysis effluent based on the ratio of the concentrations calculated in step S3 and the light intensity of the fluorescence measured by the fluorescence measurement unit 4. The calculated albumin concentration is stored in the memory unit 55.

[0040] Thereafter, in step S5, the alarm unit 54 determines whether the albumin concentration determined in step S4 is equal to or greater than a preset threshold. If the determination in step S5 is YES (Y), an alarm is issued using light, sound, or the like in step S6, and the process proceeds to step S7. If the determination in step S5 is NO (N), the process proceeds to step S7 without issuing an alarm.

[0041] In step S7, the measurement component leakage calculation unit 53 calculates the leakage amount of the measurement component since the start of treatment based on the albumin concentration determined in step S4 and the flow rate of the dialysis effluent. More specifically, as described above, the measurement component leakage calculation unit 53 calculates the average albumin concentration for one minute, multiplies the average albumin concentration by the flow rate of the dialysis effluent, and calculates the albumin leakage amount per minute, which is stored for each minute in the memory unit 55. The albumin leakage amounts per minute stored in the memory unit 55 are then added together over the entire elapsed treatment time to calculate the albumin leakage amount since the start of treatment.

[0042] Thereafter, in step S8, the alarm unit 54 determines whether the amount of albumin leakage determined in step S7 is equal to or greater than a preset threshold. If the determination in step S8 is YES (Y), an alarm is issued using light, sound, or the like in step S9, and the process proceeds to step S10. If the determination in step S8 is NO (N), the process proceeds to step S10 without issuing an alarm.

[0043] In step S10, the calculation device 5 determines whether the treatment has ended. Whether the treatment has ended can be determined, for example, by a signal from a dialysis control device. If the determination in step S10 is NO (N), the process returns to step S1 and continues to monitor the albumin concentration in the dialysis effluent. If the determination in step S10 is YES (Y), the process ends.

[0044] (Actions and Effects of the Embodiments) As described above, in the dialysis effluent component measuring device 1 of this embodiment, the measured component is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, and the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength. The device is equipped with: a light source 2 that irradiates the dialysis effluent with light of the first wavelength; a scattered light measuring unit 3 that receives scattered light of the first wavelength scattered by the dialysis effluent at multiple angles and measures the light intensity of the scattered light; a fluorescence measuring unit 4 that measures the light intensity of the fluorescence of the second wavelength; a ratio calculating unit 51 that calculates the ratio of the concentration of the measured component to the concentration of the measurement-inhibiting component contained in the dialysis effluent based on the measurement result of the scattered light measuring unit 3; and a measured component concentration calculating unit 52 that calculates the concentration of the measured component in the dialysis effluent based on the concentration ratio calculated by the ratio calculating unit 51 and the light intensity of the fluorescence measured by the fluorescence measuring unit 4.

[0045] This allows, for example, when measuring the concentration of albumin, to be distinguished from large molecular weight filtrate toxins such as β2-microglobulin contained in the dialysis effluent, and the concentration of the measured component, albumin, can be measured with sufficient accuracy. Note that the measured component is not limited to albumin and may be, for example, β2-microglobulin. In this case, albumin can be selected as the measurement inhibitor.

[0046] (Summary of the embodiment) Next, the technical ideas grasped from the above-described embodiments will be described by using the reference numerals and the like in the embodiments. However, the reference numerals and the like in the following description do not limit the components in the claims to the members and the like specifically shown in the embodiments.

[0047] [1] An apparatus for measuring the concentration of a target component contained in a dialysis effluent discharged from a blood purifier (12), wherein the target component is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, and the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength, the apparatus comprising: a light source (2) that irradiates the dialysis effluent with light of the first wavelength; and a light source (3) that receives scattered light of the first wavelength scattered by the dialysis effluent at a plurality of angles and measures the light intensity of the scattered light. A dialysis effluent component measuring device (1) comprising: a scattered light measuring unit (3); a fluorescence measuring unit (4) that measures the light intensity of the fluorescence of the second wavelength; a ratio calculating unit (51) that calculates the ratio of the concentration of the measured component to the concentration of the measurement-inhibiting component contained in the dialysis effluent based on the measurement result of the scattered light measuring unit (3); and a measured component concentration calculating unit (52) that calculates the concentration of the measured component in the dialysis effluent based on the ratio of the concentrations calculated by the ratio calculating unit (51) and the light intensity of the fluorescence measured by the fluorescence measuring unit (4).

[0048] [2] The dialysis effluent component measuring device (1) according to [1], wherein the component to be measured is albumin.

[0049] [3] The dialysis effluent component measuring device (1) according to [2], wherein the first wavelength is 250 nm or more and 330 nm or less, and the second wavelength is 300 nm or more and 400 nm or less.

[0050] [4] The dialysis effluent component measuring device (1) according to any one of [1] to [3], wherein the fluorescence measuring unit (4) has a fluorescence light receiving element (41) and a filter (42) that blocks light of the first wavelength from being incident on the fluorescence light receiving element (41) and transmits light of the second wavelength.

[0051] [5] The dialysis effluent component measuring device (1) described in [4], wherein the fluorescence measuring unit (4) has a light-guiding member (43) that guides the fluorescence generated in the dialysis effluent to the fluorescence light-receiving element (41).

[0052] [6] A method for measuring the concentration of a metered component contained in a dialysis effluent discharged from a blood purifier (12), wherein the metered component is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, and the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength, the method comprising: irradiating the dialysis effluent with light of the first wavelength from a light source (2); receiving scattered light of the first wavelength scattered by the dialysis effluent at multiple angles; measuring the light intensity of the fluorescence of the second wavelength; calculating a ratio between the concentration of the metered component contained in the dialysis effluent and the concentration of the measurement-inhibiting component based on the measurement result of the light intensity of the scattered light; and calculating the concentration of the metered component in the dialysis effluent based on the calculated concentration ratio and the measured light intensity of the fluorescence.

[0053] Although the embodiments of the present invention have been described above, the invention according to the claims is not limited to the above-described embodiments. It should be noted that not all of the combinations of features described in the embodiments are necessarily essential to the means for solving the problems of the invention. Furthermore, the present invention can be appropriately modified and implemented within the scope of its spirit. [Explanation of symbols]

[0054] 1...Dialysis waste fluid component measuring device 2…Light source 3...Scattered light measurement section 4...Fluorescence measurement section 41...Fluorescent light receiving element 42...Bandpass filter (filter) 43...Lens (light guide member) 5...Arithmetic device 51...Ratio calculation section 52...Measurement component concentration calculation section 53…Measurement component leakage amount calculation unit 54...Alarm section 6...Lens 10...Blood purification device 12...Blood purifier

Claims

1. An apparatus for measuring the concentration of a target component contained in dialysis wastewater discharged from a blood purifier, the component to be measured is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength; a light source that irradiates the dialysis effluent with light of the first wavelength; a scattered light measuring unit that receives scattered light of the first wavelength scattered by the dialysis effluent at a plurality of angles and measures the light intensity of the scattered light; a fluorescence measuring unit that measures the light intensity of the fluorescence of the second wavelength; a ratio calculation unit that calculates a ratio between the concentration of the measurement target component contained in the dialysis effluent and the concentration of the measurement inhibiting component based on the measurement result of the scattered light measurement unit; and a measurement component concentration calculation unit that calculates the concentration of the measurement component in the dialysis effluent based on the concentration ratio calculated by the ratio calculation unit and the fluorescent light intensity measured by the fluorescence measurement unit. Dialysis effluent component measuring device.

2. the component to be measured is albumin; The dialysis effluent component measuring device according to claim 1.

3. the first wavelength is equal to or greater than 250 nm and equal to or less than 330 nm, The second wavelength is 300 nm or more and 400 nm or less. The dialysis effluent component measuring device according to claim 2.

4. the fluorescence measurement unit includes a fluorescence light receiving element and a filter that blocks light of the first wavelength from being incident on the fluorescence light receiving element and transmits light of the second wavelength. The dialysis effluent component measuring device according to any one of claims 1 to 3.

5. The fluorescence measuring unit has a light guiding member that guides the fluorescence generated in the dialysis effluent to the fluorescence light receiving element. The dialysis effluent component measuring device according to claim 4.

6. A method for measuring the concentration of a target component contained in a dialysis effluent discharged from a blood purifier using a dialysis effluent component measuring device, comprising: the component to be measured is a component that is excited by light of a first wavelength and emits fluorescence of a second wavelength different from the first wavelength, the dialysis effluent contains a measurement-inhibiting component that is excited by light of the first wavelength and emits fluorescence including the second wavelength; The device, irradiating the dialysis effluent with light of the first wavelength from a light source; receiving the scattered light of the first wavelength scattered by the dialysis effluent at a plurality of angles; measuring the light intensity of the fluorescence of the second wavelength; calculating a ratio of the concentration of the measurement target component contained in the dialysis effluent to the concentration of the measurement inhibiting component based on the measurement result of the light intensity of the scattered light; calculating the concentration of the component to be measured in the dialysis effluent based on the calculated concentration ratio and the measured fluorescent light intensity; Method for measuring components in dialysis effluent.

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