Cosmetics

Abstract

To provide a cosmetic preparation which is suppressed in discoloration of alkoxysalicylic acid or a salt thereof even under harsh storage conditions, and has excellent storage stability.SOLUTION: A cosmetic preparation contains (A) alkoxysalicylic acid having a specific structure or a salt thereof, and (B) an acetophenone derivative having a specific structure or a salt thereof.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a cosmetic preparation comprising an alkoxysalicylic acid or a salt thereof. [Background technology]

[0002] It has been reported that alkoxysalicylic acid (or its salt) has an inhibitory effect on melanin production, and that topical skin preparations containing it exhibit excellent whitening effects (e.g., Patent Document 1). However, compositions containing alkoxysalicylic acid may discolor if stored for a long period of time under harsh conditions.

[0003] As a means for suppressing discoloration of alkoxysalicylic acid, a technique of using saponin or the like in combination has been proposed (for example, Patent Document 2). It is also known to use an inorganic salt such as sodium pyrosulfite in combination, but sodium pyrosulfite can produce an unpleasant odor, and there is a limit to the amount that can be added, especially in the case of fragrance-free products. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 6-40886 [Patent Document 2] Japanese Patent Application Publication No. 8-217660 Summary of the Invention

[0005] The present inventors have surprisingly found that discoloration of an alkoxysalicylic acid or its salt can be suppressed by combining an alkoxysalicylic acid or its salt with an acetophenone derivative. The present invention is based on these findings.

[0006] Therefore, the present invention discloses a cosmetic composition comprising an alkoxysalicylic acid or a salt thereof and an acetophenone derivative.

[0007] According to the present invention, the following inventions are provided. [1] (A) Alkoxysalicylic acid represented by formula (a) or its salt [ka] (In the formula, R a is an alkyl group having 1 to 6 carbon atoms), and (B) An acetophenone derivative represented by formula (b) or a salt thereof [ka] (In the formula, R b are each independently hydrogen or a methyl group, and n is 0 to 2. A cosmetic comprising: [2]R a [1] The cosmetic according to [1], wherein is a methyl group or an ethyl group. [3] The cosmetic preparation according to [1] or [2], wherein the (A) alkoxysalicylic acid or its salt is 4-methoxysalicylic acid potassium salt. [4] The cosmetic preparation according to any one of [1] to [3], wherein the (B) acetophenone derivative or its salt is hydroxyacetophenone. [5] The cosmetic preparation according to any one of [1] to [4], wherein the (B) acetophenone derivative or its salt is 4-hydroxyacetophenone. [6] The cosmetic according to any one of [1] to [5], wherein the blending amount of (A) alkoxysalicylic acid or its salt is 0.1 to 5 mass % relative to the total amount of the cosmetic. [7] The cosmetic according to any one of [1] to [6], wherein the blending amount of the (B) acetophenone derivative or its salt is 0.005 to 1 mass % relative to the total amount of the cosmetic. [8] (C1) The cosmetic preparation according to any one of [1] to [7], further comprising a sulfite or a pyrosulfite. [9] (C2) A cosmetic preparation according to any one of [1] to [8], further comprising vitamin C or a vitamin C derivative.

[10] (C3) The cosmetic preparation according to any one of [1] to [9], further comprising a chelating agent.

[11] The cosmetic preparation according to any one of [7] to [9], wherein the mass ratio of the amount of the (B) acetophenone derivative or its salt to the total amount of the (C1) sulfite or pyrosulfite, the (C2) vitamin C or vitamin C derivative, and the (C3) chelating agent is 1:0.01 to 1:1.

[0008] According to the present invention, it is possible to provide a cosmetic preparation having excellent storage stability. In particular, the present invention can suppress discoloration of a cosmetic preparation containing an alkoxysalicylic acid or a salt thereof even under harsh storage conditions.

[0009] The present invention relates to a cosmetic comprising (A) an alkoxysalicylic acid having a specific structure or a salt thereof, and (B) an acetophenone derivative having a specific structure.

[0010] (A) Alkoxysalicylic acid or its salt The cosmetic preparation according to the present invention comprises an alkoxysalicylic acid represented by formula (a) or a salt thereof (hereinafter sometimes referred to as component (A), the same applies to other components). [ka] In the formula, R a is an alkyl group having 1 to 6 carbon atoms, and may be linear or branched. a Examples of the alkyl group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a tert-butyl group, and a sec-butyl group, and preferably a methyl group or an ethyl group. substituent OR a The position of is not particularly limited, but is preferably the 3-, 4- or 5-position of salicylic acid, more preferably the 4-position.

[0011] Examples of the alkoxysalicylic acid represented by formula (a) include 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysalicylic acid, and 5-propoxysalicylic acid, and preferably 4-methoxysalicylic acid.

[0012] Alkoxysalicylic acids are known substances, and can be easily synthesized by the methods described in, for example, "Beil, 10227" for 5-methoxysalicylic acid and "Beil, 10379" for 4-methoxysalicylic acid. They are also available as reagents from Aldrich and other companies.

[0013] Component (A) is also preferably a salt of an alkoxysalicylic acid represented by formula (a). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt, but examples include alkali metal salts such as sodium salt, potassium salt, and lithium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; and amino acid salts. Potassium salt is preferred, and from the viewpoints of cosmetic effects and easy availability, potassium 4-methoxysalicylate is even more preferred.

[0014] One or more types of component (A) can be blended. The blending amount of component (A) is selected appropriately depending on the intended use and the balance with other blending ingredients, but in order to exert the functions and effects of component (A), particularly the whitening effect, the blending amount is preferably 0.1 to 5 mass %, and more preferably 0.5 to 3.5 mass %, of the total amount of the cosmetic.

[0015] (B) Acetophenone derivative or its salt The cosmetic according to the present invention comprises an acetophenone derivative represented by formula (b) or a salt thereof. [ka] During the ceremony, R bare each independently hydrogen or a methyl group, preferably hydrogen. n is 0 to 2, preferably 0 or 1, and more preferably 1. Substituent (OR b ), the position of the substituent is not limited, but when n=1, it is preferably in the para position relative to the acetyl group.

[0016] Examples of the acetophenone derivative represented by formula (b) include acetophenone, 2-hydroxyacetophenone, 3-hydroxyacetophenone, and 4-hydroxyacetophenone, with hydroxyacetophenone being preferred and 4-hydroxyacetophenone being more preferred.

[0017] Component (B) may be a salt of the acetophenone derivative represented by formula (b). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt, and examples thereof include alkali metal salts such as sodium salt, potassium salt, and lithium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; and amino acid salts. Sodium salt, potassium salt, and ammonium salt are preferred, and sodium salt is more preferred.

[0018] One or more types of component (B) can be blended. The blending amount of component (B) is preferably 0.005 to 1 mass %, more preferably 0.01 to 0.5 mass %, based on the total amount of the cosmetic. By keeping it in this range, discoloration can be suppressed while also suppressing the irritation caused by component (B).

[0019] It is known that component (A) can discolor when stored for long periods under conditions such as exposure to light, but discoloration can be suppressed by combining components (A) and (B). Without being bound by theory, this is thought to be due to the following reason: It is thought that the structure of component (A) changes due to exposure to light, causing discoloration. When component (B) coexists, it is thought that component (B) traps radicals generated in the intermediate stage of this structural change, thereby suppressing the structural change of component (A) and suppressing discoloration. To inhibit discoloration of component (A), it has been known to combine it with components (C1) to (C3) (hereinafter collectively referred to as component (C)) described below. Components (B) and (C) are thought to inhibit discoloration of component (A) through different actions, and therefore combining components (A) and (B) with component (C) is thought to produce a synergistic effect.

[0020] (C1) Sulfite or pyrosulfite The cosmetic preparation according to the present invention may further comprise (C1) a sulfite or pyrosulfite. Examples of component (C1) include sodium sulfite, sodium hydrogen sulfite, potassium sulfite, calcium sulfite, sodium pyrosulfite, and potassium pyrosulfite, with pyrosulfite being preferred and sodium pyrosulfite being more preferred. The component (C1) can be blended in one or more types. Since sulfites and pyrosulfites can produce an unpleasant odor when blended in large amounts, it is preferable to take this into consideration, especially when using them in fragrance-free cosmetics. The blending amount of component (C1) is preferably 0.001 to 0.3 mass%, more preferably 0.001 to 0.2 mass%, based on the total amount of the cosmetic. By using this range, the synergistic effect with component (B) can be achieved, effectively suppressing discoloration while suppressing the odor of sodium pyrosulfite itself.

[0021] (C2) Vitamin C or Vitamin C derivatives The cosmetic composition according to the present invention may further contain (C2) vitamin C or a vitamin C derivative. Vitamin C is also known as L-ascorbic acid. (C2) vitamin C or a vitamin C derivative is expected to be effective as a whitening agent in addition to inhibiting discoloration. Examples of component (C2) include 2-O-alkyl ascorbic acids such as L-ascorbic acid, 2-O-methyl ascorbic acid, 2-O-ethyl ascorbic acid, 2-O-propyl ascorbic acid, and 2-O-butyl ascorbic acid; 3-O-alkyl ascorbic acids such as 3-O-methyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-propyl ascorbic acid, 3-O-isopropyl ascorbic acid, 3-O-butyl ascorbic acid, and 3-O-isobutyl ascorbic acid; ascorbic acid monoalkyl esters; ascorbic acid dialkyl esters; ascorbic acid trialkyl esters; ascorbic acid triesters; and ascorbic acid glucosides. Ascorbic acid and its derivatives may be in the form of a salt. Examples of such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, alkanolamine salts, and amino acid salts. In the present invention, it is preferable to use 2-O-ethyl ascorbic acid (vitamin C ethyl). One or more types of component (C2) can be blended. The blending amount of component (C2) is preferably 0.001 to 0.5 mass% and more preferably 0.003 to 0.2 mass% relative to the total amount of the cosmetic. By keeping it in this range, discoloration can be effectively suppressed through a synergistic effect with component (B), while irritation and deterioration of the feel during use caused by component (C) can be suppressed.

[0022] (C3) Chelating agent The cosmetic preparation according to the present invention may further comprise a chelating agent (C3). Examples of component (C3) include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyltriacetate, and disodium ethylenediaminetetraacetate. One or more types of component (C3) can be blended. The blending amount of component (C3) is preferably 0.001 to 0.5% by mass, more preferably 0.01 to 0.3% by mass, based on the total amount of the cosmetic. By keeping it in this range, discoloration can be effectively suppressed through a synergistic effect with component (B), while stickiness caused by component (C) after application can be suppressed.

[0023] The mass ratio of the amount of (B) acetophenone derivative or its salt to the total amount of (C1) sulfite or pyrosulfite, (C2) vitamin C or vitamin C derivative, and (C3) chelating agent is preferably 1:0.01 to 1:1, and more preferably 1:0.05 to 1:0.6.

[0024] In addition to the above-mentioned components, the cosmetic composition according to the present invention may contain, as needed, ingredients commonly used in cosmetics, such as oily components, ultraviolet absorbers, surfactants, moisturizers, thickeners, polyhydric alcohols, powder components, synthetic resin emulsions, amino acids, organic amines, pH adjusters, antioxidants, preservatives, etc.

[0025] The oily component is not particularly limited, and examples thereof include fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, and silicones.

[0026] Examples of fats and oils include liquid fats and oils such as avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, and glycerin triisopalmitate; and solid fats and oils such as cacao butter, coconut oil, horse tallow, hardened coconut oil, palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, Japan wax kernel oil, hardened oil, beef leg fat, Japan wax, and hardened castor oil.

[0027] Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivory wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

[0028] Examples of hydrocarbon oils include oils such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.

[0029] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0030] Examples of higher alcohols include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol; and branched-chain alcohols such as monostearyl glycerin ether (batyl alcohol), 2-decyltetradecynol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

[0031] Examples of synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid esters, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetraethylhexanoate, Taerythrityl, glycerin tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N- Lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, crotamiton (C13 H 17 NO) etc.

[0032] Examples of silicone oils include linear silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic silicone oils such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and tetramethyltetrahydrogencyclopolysiloxane; alkyl-modified silicone oils that are liquid at room temperature such as caprylmethicone, capryltrimethicone, and stearylmethicone; and fluorine-modified silicone oils such as dimethylsiloxane-diphenylsiloxane-methyl(perfluoroalkyl)siloxane copolymers.

[0033] Examples of silicones include alkyl and alkoxy silicone waxes such as stearyl-modified dimethicone and behenyl-modified dimethicone, silicone resins that form a three-dimensional network structure, and silicone rubber.

[0034] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate. Salicylic acid-based ultraviolet absorbers such as octyl methoxycinnamate, glyceryl di-para-methoxycinnamate-mono-2-ethylhexanoate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate, Cyclocinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, 3,4,5-trimethoxycinnamate-3-methyl-4-[methylbis(trimethylsiloxy)silyl]butyl, methyl trimethoxycinnamate Cinnamic acid-based ultraviolet absorbers such as bis(trimethylsiloxy)silylisopentyl; benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, and 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate;Examples include 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, urocanic acid, urocanic acid ethyl ester, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, and dimorpholinopyridazinone.

[0035] Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, and diglycerol sorbitan penta-2-ethylhexylate; glycerin or polyglycerin esters such as glycerin monostearate, α,α'-oleic acid pyroglutamic acid glycerin, and glycerin monostearate malate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; and glycerin alkyl ethers.

[0036] Examples of hydrophilic nonionic surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monostearate; polyoxyethylene sorbit fatty acid esters such as polyoxyethylene sorbit monolaurate, polyoxyethylene sorbit monooleate and polyoxyethylene sorbit monostearate; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate and polyoxyethylene glycerin triisostearate; polyoxyethylene fatty acid esters such as polyoxyethylene monooleate and polyoxyethylene distearate; polyoxyethylene alkyl ethers such as polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene-2-octyldodecyl ether and polyoxyethylene cholestanol ether; polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene alkylphenyl ethers such as polyoxyethylene dinonylphenyl ether; Pluronic type surfactants such as Pluronic; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene-2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene polyoxypropylene, hydrogenated lanolin, polyoxyethylene polyoxypropylene glycerin ether, PPG-13 decyltetradeceth-24 and other polyoxyethylene polyoxypropylenes; Propylene alkyl ethers; tetrapolyoxyethylene-tetrapolyoxypropylene ethylenediamine condensates such as Tetronic; polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleate, and other polyoxyethylene castor oil derivatives or polyoxyethylene hydrogenated castor oil derivatives;Examples include alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide, as well as polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, sucrose fatty acid esters, polyoxyethylene nonylphenyl formaldehyde condensates, alkylethoxydimethylamine oxide, and trioleyl phosphate;

[0037] Examples of anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, alkyl ether sulfates such as polyoxyethylene triethanolamine lauryl sulfate and polyoxyethylene sodium lauryl sulfate, N-acyl sarcosinates such as sodium lauroyl sarcosinate, higher fatty acid amide sulfonates such as sodium N-myristoyl-N-methyl taurate, sodium N-stearoyl-N-methyl taurate, sodium coconut oil fatty acid methyl taurate, and sodium lauryl methyl taurate, phosphate ester salts such as polyoxyethylene oleyl ether sodium phosphate and polyoxyethylene stearyl ether sodium phosphate, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene, and the like. Examples of suitable surfactants include sulfosuccinates such as sodium diethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzenesulfonates such as sodium linear dodecylbenzenesulfonate and triethanolamine linear dodecylbenzenesulfonate; N-acylglutamates such as monosodium N-lauroylglutamate and disodium N-stearoylglutamate; and higher fatty acid ester sulfates such as hydrogenated coconut oil fatty acid glycerin sodium sulfate, as well as polyoxyethylene alkyl ether carboxylates, α-olefin sulfonates, higher fatty acid ester sulfonates, secondary alcohol sulfates, higher fatty acid alkylolamide sulfates, sodium lauroyl monoethanolamide succinate, N-palmitoyl aspartic acid, ditriethanolamine, and coconut oil fatty acid collagen hydrolyzed alkali salts.

[0038] Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, dialkyldimethylammonium salts such as distearyldimethylammonium chloride, alkylpyridinium salts such as poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride and cetylpyridinium chloride, as well as alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, polyoxyethylene alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, cationic polymers, and β-NN-dimethyl-N-ethylammonioethyl acrylate vinylpyrrolidone chloride copolymers.

[0039] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants such as 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt; and betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, and sulfobetaine.

[0040] Examples of moisturizing agents include cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, urea, and diglycerin ethylene oxide / propylene oxide adduct. In particular, when acidic mucopolysaccharides such as chondroitin sulfate and hyaluronic acid are added, the whitening effect of alkoxysalicylic acid and / or its salts is enhanced.

[0041] Examples of thickeners include gum arabic, carrageenan, tragacanth gum, quince seed, casein, sodium caseinate, dextrin, gelatin, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, guar gum, xanthan gum, magnesium aluminum silicate, bentonite, and hectorite.

[0042] Examples of polyhydric alcohols include ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, erythritol, trimethylolpropane, pentaerythritol, sorbitol, maltitol, diglycerin, and polyethylene glycol.

[0043] Examples of powder components include inorganic powders such as talc, kaolin, mica, sericite, phlogopite, synthetic mica, magnesium carbonate, calcium carbonate, aluminum silicate, silica, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate, etc.), and boron nitride; organic powders such as polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polymethylsilsesquioxane powder, and cellulose powder; titanium dioxide, Examples of pigments include inorganic pigments such as zinc oxide, iron oxide (red ocher), iron titanate, yellow iron oxide, black iron oxide, carbon black, low-order titanium oxide, mango violet, cobalt violet, chromium oxide, ultramarine, and Prussian blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder; organic pigments such as Red No. 201, Red No. 202, Orange No. 203, Yellow No. 205, Yellow No. 401, and Blue No. 404; organic pigments such as zirconium, barium, and aluminum lakes in Red No. 3, Yellow No. 4, Green No. 3, and Blue No. 1; and natural pigments such as chlorophyll and beta-carotene.

[0044] Examples of synthetic resin emulsions include acrylic resin emulsions and polyvinyl acetate resin emulsions.

[0045] Examples of amino acids include glycine, leucine, phenylalanine, tyrosine, aspartic acid, glutamic acid, sodium glutamate, arginine, histidine, lysine, cystine, cysteine, sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, glutathione, and pyrrolidone carboxylic acid.

[0046] Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0047] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate. Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters. Examples of preservatives include phenoxyethanol, ethylparaben, and butylparaben.

[0048] Other ingredients that can be added include caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, glabridin, hot water extract of fire thorn fruit, various herbal medicines, tocopherol acetate, glycyrrhizic acid and its derivatives or salts; other whitening agents such as arbutin; and sugars such as glucose, fructose, mannose, sucrose, and trehalose. In particular, when vitamin E esters such as tocopherol acetate are added, the whitening effect of alkoxysalicylic acid and / or its salts is enhanced.

[0049] Examples of the cosmetic preparations according to the present invention include solubilized systems such as lotions and liquids; emulsions such as milky lotions and creams; dispersions such as makeup cosmetics, as well as packs, jellies, ointments, and the like.

[0050] The cosmetic of the present invention can be produced by a conventional method. When the cosmetic of the present invention is an emulsion cosmetic, the emulsification method is not particularly limited. [Example]

[0051] The present invention will be described in detail based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the contents are expressed in mass % relative to the total amount.

[0052] [Examples 1 to 6 and Comparative Examples 1 and 2] Cosmetics of Examples 1 to 6 and Comparative Examples 1 and 2 were prepared according to the formulations shown in Table 1. The pH of the obtained cosmetics is as shown in Table 1. [Table 1]

[0053] [Color difference evaluation] The cosmetics of the examples and comparative examples were placed in 50 ml sample tubes and left for one week in a high-illuminance environment of 6000 Lx or more. The L, a, and b values ​​were then measured using a color difference meter ("Spectrophotometer CM-2002", Konica Minolta, Inc.), and the color difference ΔE from the measured value when ion-exchanged water was used was calculated from the colorimetric values. The results obtained are shown in Table 1.

[0054] [Color Sensory Evaluation] The change in color tone after exposure to the high-illuminance environment was evaluated visually. The evaluation criteria were as follows. The results are shown in Table 1. A+: No discoloration is observed. A: Almost no discoloration is observed. B: Slight discoloration is observed. C: Discoloration is observed. D: Significant discoloration.

[0055] The results in Table 1 show that cosmetics containing a combination of (A) alkoxysalicylic acid or its salt and (b) acetophenone exhibit reduced color difference even after storage under high-light conditions, and that sensory evaluation also shows reduced discoloration.

Claims

[Claim 1] (A) An alkoxysalicylic acid represented by formula (a) or a salt thereof 【Chemistry 1】 (In the formula, R ａ is an alkyl group having 1 to 6 carbon atoms), and (B) An acetophenone derivative represented by formula (b) or a salt thereof 【Chemistry 2】 (In the formula, R ｂ are each independently hydrogen or a methyl group, and n is 0 to 2. A cosmetic comprising: the (A) alkoxysalicylic acid or its salt is 4-methoxysalicylic acid potassium salt, and the blending amount of the (A) alkoxysalicylic acid or its salt is 0.1 to 5 mass% relative to the total amount of the cosmetic; the (B) acetophenone derivative or its salt is 4-hydroxyacetophenone, and the blending amount of the (B) acetophenone derivative or its salt is 0.005 to 1 mass % relative to the total amount of the cosmetic; i) (C1) sulfites or pyrosulfites, or (C2) one or more selected from the group consisting of L-ascorbic acid, 2-O-alkyl ascorbic acids, 3-O-alkyl ascorbic acids, ascorbic acid monoalkyl esters, ascorbic acid dialkyl esters, ascorbic acid trialkyl esters, ascorbic acid triesters, ascorbic acid glucosides, and salts thereof; and ii) (C3) a chelating agent; and further including a combination of A cosmetic preparation in which the mass ratio of the blending amount of the (B) acetophenone derivative or its salt to the total blending amount of the (C1) component sulfite or pyrosulfite, the (C2) component, and the (C3) chelating agent is 1:0.05 to 1:0.6.

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