topical skin preparations

Abstract

To provide a topical skin preparation that shows excellent thickening effect even in the presence of an electrolyte, also suppresses twisting due to the agglomeration of polymers, and causes no stickiness or sliminess when in use, providing excellent usability.SOLUTION: A topical skin preparation contains following components (A)-(D): (A) electrolyte 0.01-5 mass%, (B) carrageenan 0.1-1 mass%, (C) water-soluble cellulose ether and (D) water, with the mass content ratio between component (B) and component (C) (C) / (B) of 0.01-1.2.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] Polymers are used in topical skin preparations to improve usability, such as emulsion (dispersion) stability and spreadability when applied to the skin. Polymers used in topical skin preparations have excellent thickening effects, and carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers in particular are widely used to stabilize emulsion-based cosmetics or to impart viscosity to lotion-based cosmetics.

[0003] On the other hand, electrolytes are cited as active ingredients in topical skin preparations. Many commonly used polymers, such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers, are known to reduce viscosity in the presence of a certain amount or more of electrolytes. Previously, polymers that exhibit excellent thickening effects even in the presence of electrolytes have been reported. For example, a technology for a topical skin preparation characterized by a viscosity of 2,000 to 30,000 mPa·s (30°C) has been disclosed, which contains a salt-type whitening agent selected from ascorbic acid compounds and / or alkoxysalicylic acid compounds, and carrageenan (see Patent Document 1). Another technology has been disclosed for a foam cosmetic preparation containing L-ascorbic acid 2-glucoside, carrageenan, N-stearoyl-L-glutamic acid and / or its salt, a linear aliphatic higher alcohol having 12 to 22 carbon atoms, and carbon dioxide as a propellant (see Patent Document 2). However, when a certain amount or more of polymer is incorporated, non-uniformity occurs, leading to clumping due to aggregation of the polymer, which poses usability issues. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2005-120051 [Patent Document 2] Japanese Patent Application Publication No. 2019-178075 Summary of the Invention [Problem to be solved by the invention]

[0005] While the techniques disclosed in Patent Documents 1 and 2 exhibit a thickening effect in the presence of electrolytes, they are not sufficiently effective in suppressing slippage due to polymer aggregation, leaving room for improvement. Furthermore, there are cases where the usability, such as the absence of stickiness and sliminess during use, is insufficient. Therefore, the present invention aims to provide an external skin preparation that exhibits an excellent thickening effect even in the presence of electrolytes, while suppressing slippage due to polymer aggregation and providing excellent usability without stickiness or sliminess during use. [Means for solving the problem]

[0006] Therefore, the inventor conducted extensive research to solve the above problems and discovered that by using a water-soluble cellulose ether in a topical skin preparation containing electrolytes and carrageenan, even though the total amount of polymer increases, it is possible to suppress creasing due to aggregation of the polymer and at the same time to achieve an excellent feel during use that is neither sticky nor slimy, thereby completing the present invention.

[0007] That is, the present invention includes the following. [1] The following components (A) to (D): (A) Electrolyte 0.01~5% by mass (B) Carrageenan 0.1 to 1% by mass (C) Water-soluble cellulose ether (D)Water The external skin preparation contains the above, and the mass ratio (C) / (B) of the component (B) to the component (C) is 0.01 to 1.2. [2] The topical skin preparation according to the above item [1], wherein the component (A) is a water-soluble ascorbic acid and / or a glycyrrhizinate. [3] The topical skin preparation according to [1] or [2] above, wherein the total content of the component (B) and the component (C) in the topical skin preparation is 0.1 to 1.5% by mass. [4] The external skin preparation according to any one of [1] to [3] above, wherein the component (C) is one or more selected from hydroxyethyl cellulose, carboxymethyl cellulose, and hydroxypropyl methyl cellulose. [5] The external skin preparation according to any one of [1] to [4] above, wherein the content mass ratio of the components (A) to (C), [(A)+(B)] / (C), is 1 to 300. [6] The external skin preparation according to any one of the above [1] to [5], wherein the component (C) is a combination of hydroxyethyl cellulose and carboxymethyl cellulose. [7] The topical skin preparation according to any one of [1] to [6] above further contains 10 to 30% by mass of component (E) polyhydric alcohol in the topical skin preparation, and the content of glycerin in component (E) polyhydric alcohol is 20% by mass or more. [8] The external skin preparation according to any one of [1] to [7] above, wherein the content of (C) is 0.01 to 0.5% by mass. [9] The sheet-form external skin preparation according to any one of [1] to [8] above, characterized in that it is used by being applied to or impregnated into a sheet material.

[10] The external skin preparation according to any one of [1] to [9] above, wherein the external skin preparation is a polymer aggregation inhibitor.

[11] The method for inhibiting polymer aggregation according to any one of the above [1] to [9]. [Effects of the Invention]

[0008] According to the present invention, by using a water-soluble cellulose ether in a composition containing an electrolyte and carrageenan, it is possible to suppress the occurrence of sagging due to aggregation of the polymers, even though the total amount of the polymers increases. Furthermore, the topical skin preparation of the present invention has excellent usability, being free from stickiness and sliminess during use. DETAILED DESCRIPTION OF THE INVENTION

[0009] The present invention will be described in detail below. In this specification, the symbol "to" means a range including the numerical values ​​before and after it.

[0010] Component (A): Electrolyte The electrolyte component (A) used in the present invention is a water-soluble cosmetic ingredient dermatologically effective for the skin, and can be any of those commonly used in topical skin preparations, whether organic or inorganic. Specific examples include organic compounds such as amino acids, lactic acid, citric acid, and pyrrolidonecarboxylic acid, and their metal salts such as potassium, sodium, magnesium, and calcium, and inorganic salts such as sodium chloride and magnesium chloride, as well as L-alanine, β-alanine, L-arginine, L-arginine hydrochloride, L-asparagine monohydrate, L-aspartic acid, polyaspartic acid, L-citrulline, L-cysteine, L-cysteine ​​hydrochloride monohydrate, L-dopa, L-glutamic acid, L-glutamic acid hydrochloride, L-glutamine, polyglutamic acid, glycine, trimethylglycine, L-histidine, and the like. Examples of suitable electrolytes include amino acids such as thiamin, L-histidine hydrochloride monohydrate, L-hydroxyproline, L-isoleucine, L-leucine, L-lysine, L-lysine hydrochloride, L-methionine, L-ornithine hydrochloride, L-proline, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-tyrosine, and L-valine, as well as derivatives and salts thereof, and water-soluble ascorbic acids such as ascorbic acid, ascorbic acid phosphate, ascorbic acid sulfate, ascorbic acid glucoside, and their metal salts such as sodium, potassium, magnesium, and calcium. Other examples include glycyrrhizinates, glycyrrhetinates, salicylates, tranexamates, nicotinamide, kojic acid, urea, and alum. Examples also include aqueous solutions of natural origin containing these electrolytes, such as deep sea water and hot spring water. These can be used alone or in combination depending on the purpose of the formulation.

[0011] Among these, in the topical skin preparation of the present invention, water-soluble ascorbic acids and / or glycyrrhizinates, which have excellent whitening, anti-inflammatory, and antioxidant effects, are preferred, with water-soluble ascorbic acids being more preferred. Water-soluble ascorbic acids are preferably ascorbic acid phosphate, ascorbic acid sulfate, or ascorbic acid glucoside, with ascorbic acid glucoside being more preferred from the viewpoints of whitening, antioxidant, and thickening effects. Commercially available examples of L-ascorbic acid 2-glucoside used in the present invention include AA2G (manufactured by Hayashibara Co., Ltd.), which is L-ascorbic acid 2-glucoside, and AA-2G solution (Clairage) (manufactured by Ichimaru Pharcos Co., Ltd.), which is an aqueous solution containing L-ascorbic acid 2-glucoside. In addition, component (A) can form a highly thixotropic gel with the carrageenan component (B). Note that the term "gel" as used herein refers to a gel that exhibits a significant increase in static viscosity but whose viscosity easily decreases when subjected to a light force such as shaking.

[0012] The content of component (A) in the topical skin preparation in the present invention is 0.01 to 5% by mass (hereinafter, "% by mass" will be abbreviated simply as "%"), preferably 0.1 to 4%, and more preferably 1 to 3%. If the content of component (A) exceeds 5%, the thickening effect of the polymer is suppressed, and the product may become very sticky during use and have a poor feel when used.

[0013] Ingredient (B): Carrageenan The component (B) carrageenan used in the present invention is a polysaccharide extracted from red algae, and has a structure in which D-galactose is alternately linked via α-1,3 or β-1,4 bonds. When used in topical skin preparations, it is usually dispersed in an aqueous medium at room temperature, and then heated and vigorously stirred to obtain a swollen gel.

[0014] Commercially available examples of the carrageenan used as component (B) in the present invention include iota-type carrageenan GENUGEL CJ (manufactured by Sansho Co., Ltd.) and GENUVISCO PJ-JPE (manufactured by Sansho Co., Ltd.), kappa-type carrageenan GENUGEL WG-108 (manufactured by Sansho Co., Ltd.), GENUVISCO CSW-2 (manufactured by Sansho Co., Ltd.) and Carrageenan J (manufactured by Kyokuto Chemical Industry Co., Ltd.), and lambda-type carrageenan GENUVISCO CSM-2 (manufactured by Sansho Co., Ltd.) etc. Among these, iota-type carrageenan is preferred because it does not feel sticky during use, exhibits a high thickening effect in the presence of electrolytes, and can be obtained in a gel-like form.

[0015] The content of component (B) in the topical skin preparation of the present invention is 0.1 to 1%, and from the viewpoints of being non-sticky, non-slip and having a gel-like form during use, it is preferably 0.1 to 0.8%, and more preferably 0.1 to 0.5%.

[0016] Component (C): Water-soluble cellulose ether The water-soluble cellulose ether of component (C) used in the present invention is not particularly limited as long as it is typically used in external skin preparations. Specific examples of water-soluble cellulose ethers include methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cationic hydroxyethylcellulose, hydrophobically modified hydroxyethylcellulose, and cationic hydrophobically modified hydroxyethylcellulose. Furthermore, when carboxymethylcellulose contains a salt, the salt is not particularly limited. Preferred examples of carboxymethylcellulose salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium, triethanolamine, and triethylamine, and basic amino acid salts such as lysine and arginine. These water-soluble cellulose ethers can be used alone or in combination. These cellulose ethers are not particularly limited by their origin, whether natural or synthetic.

[0017] Among these, in the present invention, from the viewpoint of excellent suppression of twisting due to polymer aggregation and non-stickiness and non-slipidity during use, component (C) is preferably hydroxyethyl cellulose, carboxymethyl cellulose, or hydroxypropyl methyl cellulose, and more preferably hydroxyethyl cellulose or carboxymethyl cellulose. Commercially available examples of hydroxyethyl cellulose include NATROSOL 250HHR (manufactured by ASHLAND SPECIALTY INGREDIENTS), and commercially available examples of carboxymethyl cellulose include CMC Daicel 1170, CMC Daicel 1180, CMC Daicel 1270, CMC Daicel 1280, CMC Daicel 1290, CMC Daicel 1350, and CMC Daicel 1380 (all manufactured by Daicel Chemical Industries, Ltd.).

[0018] Furthermore, in the present invention, it is more preferable to use two types of component (C) in combination, and it is even more preferable to use two types of hydroxyethyl cellulose and carboxymethyl cellulose in combination, because this significantly suppresses wrinkling due to polymer aggregation.

[0019] The content of component (C) in the present invention is not particularly limited as long as it is the content normally used in topical skin preparations, but from the viewpoint of excellent effects in suppressing slippage due to polymer aggregation and non-stickiness and non-slipidity during use, the lower limit in the topical skin preparation is preferably 0.01% or more, more preferably 0.02% or more, and even more preferably 0.05% or more, and the upper limit is preferably 1% or less, more preferably 0.5% or less, and even more preferably 0.3% or less.

[0020] In the present invention, the mass ratio (C) / (B) of the components (B) and (C) is preferably 0.01 or more, more preferably 0.02 or more, and even more preferably 0.05 or more, as a lower limit, from the viewpoint of suppressing twisting due to polymer aggregation and improving the lack of stickiness and sliminess during use. The upper limit is preferably 1.2 or less, more preferably 1.0 or less, and even more preferably 0.8 or less.

[0021] Furthermore, in the present invention, the total content (B) + (C) of components (B) and (C) in the topical skin preparation is preferably 0.05% or more, more preferably 0.1% or more, even more preferably 0.2% or more, and even more preferably 0.3% or more, as a lower limit. The upper limit is preferably 1.5% or less, more preferably 1.1% or less, and even more preferably 0.8% or less. Within this range, the effect of suppressing creasing due to polymer aggregation and the absence of stickiness and sliminess during use are excellent.

[0022] In the present invention, the content mass ratio of components (A) to (C), [(A)+(B)] / (C), is not particularly limited, but in terms of the effect of suppressing twisting due to polymer aggregation and the absence of stickiness and sliminess during use, the lower limit is preferably 1 or more, more preferably 5 or more, even more preferably 10 or more, and even more preferably 30 or more. The upper limit is preferably 300 or less, more preferably 200 or less, and even more preferably 150 or less.

[0023] Ingredient (D): Water The water used as component (D) in the present invention is not particularly limited as long as it is one that is commonly used in external skin preparations, etc. In addition to purified water, deep sea water or steam-distilled water from plants such as rose water or lavender water may also be used within the scope that does not impair the effects of the present invention, and one or more types may be appropriately selected and used as needed.

[0024] The content of component (D) in the present invention is not particularly limited as long as it is the content normally used in external skin preparations, but is preferably 30 to 95% in the external skin preparation.

[0025] Component (E): Polyhydric alcohol Furthermore, in the present invention, the use of a polyhydric alcohol as component (E) can improve the effect of suppressing creasing due to polymer aggregation and the absence of stickiness and sliminess during use. While component (E) is not particularly limited, it is preferably a polyhydric alcohol having 3 to 10 carbon atoms, and more preferably a polyhydric alcohol with an IOB value of 1.5 to 10. Specific examples include glycerin (IOB value = 5.0), dipropylene glycol (IOB value = 1.8), 1,3-butylene glycol (IOB value = 2.5), 1,3-propanediol (IOB value = 3.33), diglycerin (IOB value = 3.5), and sorbitol (IOB value = 5.0). While these may be used alone, it is more preferable to use two or more of them in combination. Here, the IOB value is the ratio of inorganic value to organic value (Inorganic Organic Balance) determined based on Atsushi Fujita's Organic Conceptual Diagram.

[0026] The content of component (E) in the present invention is not particularly limited, but the lower limit in the topical skin preparation is preferably 1% or more, more preferably 3% or more, and even more preferably 5% or more. The upper limit is preferably 30% or less, more preferably 25%, and even more preferably 20% or less. Furthermore, in the present invention, it is preferable that the mass ratio of glycerin in the polyhydric alcohol component (E) (glycerin / polyhydric alcohol) is 20% or more, since this results in an excellent topical skin preparation that is effective in suppressing creasing due to polymer aggregation and is free of stickiness and sliminess during use.

[0027] Furthermore, the pH of the external skin preparation of the present invention is not particularly limited, but the pH at 25°C is preferably within the range of 4.0 to 8.0.

[0028] In addition to the above components (A) to (E), the topical skin preparation of the present invention may contain appropriate components used in conventional topical skin preparations, provided that the effects of the present invention are not impaired. For example, the topical skin preparation may contain oils such as higher alcohols, hydrocarbon oils, ester oils, waxes, and silicone oils, aqueous components such as surfactants, water-soluble polymers, and lower alcohols, UV absorbers, antioxidants, antibacterial agents, preservatives, moisturizers, pH adjusters, cooling agents, powders, vitamins, cosmetic ingredients, and fragrances.

[0029] The topical skin preparation of the present invention may contain oils such as higher alcohols, fatty acids, hydrocarbon oils, fats and oils, ester oils, waxes, silicone oils, and fluorine-based oils. However, it is known that smearing due to polymer aggregation is masked by the oil, and therefore occurs more significantly when the oil content is low. Therefore, in order to more significantly exhibit the effects of the present invention, such as the effect of suppressing smearing due to polymer aggregation and the absence of stickiness and sliminess during use, the content of these oils in the topical skin preparation is preferably 5% or less, more preferably 3% or less, and even more preferably 1% or less, and may not be contained at all. In the present invention, the inclusion of an oil may cause the topical skin preparation to become cloudy and may no longer be transparent or translucent.

[0030] The method for producing the topical skin preparation of the present invention is not particularly limited, but it is preferable to produce it by a method including the following steps. Components (B) and (C) are added to an aqueous medium containing a portion of component (D), mixed and dissolved at 70 to 80°C, and then allowed to cool or cooled with stirring, after which components (A), (D), (E) and other components are added and mixed with stirring.

[0031] The dosage form of the present invention is not particularly limited and may be an aqueous type, solubilized type, oil-in-water type, water-in-oil type, oil-based type, water-in-oil-in-water type, oil-in-water-in-oil type, multi-layer type, etc., but is preferably an aqueous type, solubilized type, or oil-in-water type.

[0032] The topical skin preparation of the present invention can be implemented in various forms, such as liquid, gel, or cream. Liquid to gel forms are preferred to better demonstrate the effects of the present invention, such as the suppression of smearing due to polymer aggregation and the absence of stickiness and sliminess during use. Here, liquid to gel means a viscosity of 50,000 mPa·s or less as measured at 25°C using a Brookfield rotational viscometer. From the viewpoint of more pronounced demonstration of the effects of the present invention, a viscosity of 500 to 20,000 mPa·s is preferred, 1,000 to 10,000 mPa·s is more preferred, and 2,000 to 10,000 mPa·s is even more preferred. Furthermore, in the present invention, a gel form is particularly preferred from the viewpoint of ease of use, such as the lack of dripping, ease of application to the skin, and the provision of a moisturizing feeling.

[0033] Furthermore, from the viewpoint of aesthetic value, the appearance of the present invention is preferably transparent to translucent.

[0034] The topical skin preparation of the present invention can be used as a skin cosmetic, and examples thereof include lotions, emulsions, creams, serums, massage products, packs, hand creams, body lotions, sunscreens, foundations, eye shadows, eyeliners, concealers, scalp treatments, and the like. In terms of the noticeable effects, skin care cosmetics are preferred. Methods of use include application to hands, fingers, or cotton, application by coating or impregnation into sheet materials, and direct spraying. When applying or impregnating into sheet materials, a certain amount or more of the composition is applied to the skin compared to normal use, resulting in increased wrinkling due to polymer aggregation, stickiness, and sliminess during use. However, the combination of the present invention provides excellent suppression of wrinkling due to polymer aggregation, and excellent lack of stickiness and sliminess during use. Therefore, from the viewpoint of further exerting the effects of the present invention, application by coating or impregnation into sheet materials (sheet-type topical skin preparations) is more preferred.

[0035] The sheet material to be applied to or impregnated with the topical skin preparation of the present invention is a sheet made by intertwining fibers such as natural fibers and synthetic fibers without weaving them, and may be obtained by either a wet manufacturing method or a dry manufacturing method. Fibers used in the sheet material include cellulose, cotton, wool, hemp, pulp, silk, rayon, nylon, polyester, polypropylene, acrylic fibers, vinylon, and aramid fibers, and one or more of these may be appropriately selected and used as needed. Among these, cellulose and / or rayon are preferred in terms of stability and adhesion to the skin.

[0036] In the present invention, the method of coating or impregnating the sheet material is not particularly limited, and the sheet material can be coated or impregnated by a known method. [Example]

[0037] The effects of the present invention will be explained using the following examples and comparative examples. However, the technical scope of the present invention is not limited to the following examples. Unless otherwise specified, each operation is carried out at room temperature (25°C). Examples 1 to 17 and Comparative Examples 1 to 6: Skin topical preparations Topical skin preparations were prepared according to the formulations shown in Table 1 below, and the effects of suppressing slippage due to polymer aggregation, and the absence of stickiness and sliminess during use were evaluated using the methods described below. The results are also shown in Tables 1 and 2.

[0038] Table 1 JPEG0007763587000001.jpg127166Note 1: GENUVISCO PJ-JPE (manufactured by Sanshosha) Note 2: Carrageenan J (Kyokuto Chemical Industry Co., Ltd.) *3: NATROSOL 250HHR (Ashland Specialty Ingredients) Note 4: CMC Daicel 1170 (manufactured by Daicel Chemical Industries, Ltd.)

[0039] Table 2 JPEG0007763587000002.jpg108166

[0040] (Manufacturing method) A: Components (4) to (12) and a portion of component (17) are heated and mixed uniformly at 70 to 80°C. B: After cooling A, ingredients (1) to (3) and ingredients (13) to (17) were added and mixed uniformly to obtain an external preparation for skin.

[0041] (Evaluation Method 1) Ten expert panelists in their 20s to 40s who had received training in sensory evaluation and were capable of evaluation according to a set standard were selected. The expert panelists applied 2 g of each sample to their forearms, and each sample was evaluated and scored on a four-point absolute scale based on the following criteria for the effect of preventing creasing due to polymer coagulation, the absence of stickiness during use, and the absence of sliminess. The average score for each sample was calculated from the total scores of all panelists, and the results were judged according to the following four-point scale. For the effect of preventing creasing due to polymer coagulation, a score of △ or higher was considered practically acceptable, and for the absence of stickiness and sliminess during use, a score of ○ or higher was considered practically acceptable.

[0042] (B: Suppression of twisting due to polymer aggregation) <Absolute evaluation criteria> (Rating): (Evaluation) 4 points: No wrinkles due to polymer aggregation 3 points: No noticeable wrinkling due to polymer aggregation 2 points: Some wrinkling due to polymer aggregation is felt 1 point: There is a strong sense of distortion due to polymer aggregation. <4-level evaluation criteria> (Judgment): (Average score) ◎: Over 3.5 points: Extremely good ○: Over 3.0 points, 3.5 points or less: Very good △: Over 2.0 points, 3.0 points or less: Good × :2.0 points or less :Poor (B: No stickiness when used) <Absolute evaluation criteria> (Rating): (Evaluation) 4 points: No stickiness 3 points: Not very sticky 2 points: Slightly sticky 1 point: Sticky feeling <4-level evaluation criteria> (Judgment): (Average score) ◎: Over 3.25 points: Very good ○: Over 2.5 points, 3.25 points or less: Good △: Over 1.75 points and 2.5 points or less: Slightly poor × : 1.75 points or less : Defective (H: No slipperiness) <Absolute evaluation criteria> (Rating): (Evaluation) 4 points: No slimy feeling 3 points: Not very slippery 2 points: Feels a little slimy 1 point: Feels slimy <4-level evaluation criteria> (Judgment): (Average score) ◎: Over 3.25 points: Very good ○: Over 2.5 points, 3.25 points or less: Good △: Over 1.75 points and 2.5 points or less: Slightly poor × : 1.75 points or less : Defective

[0043] As is clear from the results in Tables 1 and 2, the topical skin preparations of Examples 1 to 17 of the present invention were superior to the topical skin preparations of Comparative Examples 1 to 6 in terms of the effect of suppressing creasing due to polymer aggregation, and in terms of the absence of stickiness and sliminess during use.

[0044] In contrast, Comparative Examples 1 and 2, in which thickening polymers such as carboxyvinyl polymer and alkyl acrylate / methacrylate were used instead of component (B), were unsatisfactory in terms of non-stickiness and non-slipidity during use. Comparative Example 3, in which sodium alginate was used instead of component (B), was unsatisfactory in terms of the effect of suppressing twisting due to polymer coagulation, and the effect of non-stickiness and non-slipidity during use. Similarly, Comparative Examples 4 and 5, which did not contain component (C), were unsatisfactory in terms of the effect of suppressing twisting due to polymer coagulation, and the effect of non-stickiness and non-slipidity during use. Furthermore, Comparative Example 6, in which the mass ratio (C) / (B) of component (B) to component (C) exceeded 1.2, was unsatisfactory in terms of the effect of suppressing twisting due to polymer coagulation, and the effect of non-stickiness and non-slipidity during use.

[0045] Next, the results of using the product of the present invention in a different embodiment will be shown.

[0046] Examples 1, 7, 11, 16 and Comparative Examples 1 and 2: Sheet-type topical skin preparations Using the above-mentioned Examples 1, 7, 11, and 16 and Comparative Examples 1 and 2, sheet-type external skin preparations were investigated according to the following procedure. The evaluation method and criteria were as described above. The evaluation results are shown in Table 3.

[0047] Table 3 JPEG0007763587000003.jpg165166

[0048] 30 mL of the topical skin preparations obtained in the above Examples and Comparative Examples was impregnated into a nonwoven fabric (cellulose) to obtain a sheet-shaped topical skin preparation.

[0049] Furthermore, as is clear from the results in Table 3, the sheet-type topical skin preparations of Comparative Examples 1 and 2, which were applied to the skin in a certain amount or more of the composition compared to normal use, suffered from worsening of crease due to polymer aggregation, whereas the sheet-type topical skin preparations of Examples 1, 7, 11, and 16 of the present invention were excellent in terms of the effect of suppressing crease due to polymer aggregation, and in terms of non-stickiness and non-slipness during use. Furthermore, the sheet-type topical skin preparations exhibited a greater effect of suppressing crease due to polymer aggregation, and in terms of non-stickiness and non-slipness during use than the topical skin preparations of Tables 1 and 2, demonstrating the remarkable effectiveness of the present invention. Example 16 in Table 3 is also rated ◎ in the table, but the average score for the effect of suppressing crease due to polymer aggregation was 3.9, which was superior to that of Example 16 in Table 2, which was 3.7.

[0050] Example 18: Lotion (Component) (%) (1) L-Ascorbic Acid 2-Glucoside (Component (A)) 3.0 (2) Carrageenan (ingredient (B)) Note 1 0.2 (3) Hydroxyethyl cellulose (component (C)) Note 3 0.05 (4) Polyoxyethylene isostearate (50) Hydrogenated castor oil 0.2 (5)Fragrance 0.1 (6) Tocopherol 0.1 (7) Ethanol 10.0 (8) Methylparaben 0.2 (9) Phenoxyethanol 0.2 (10) Glycerin (ingredient (E)) 5.0 (11) 1,3-butylene glycol (ingredient (E)) 10.0 (12) Polyoxyethylene methyl glucoside Note 5 2.0 (13) Carboxyvinyl polymer 0.05 (14) Sodium hydroxide 0.05 (15) Remaining amount of purified water (ingredient (D)) Note 5: MacbioBride MG-10E (NOF Corporation)

[0051] (Manufacturing method) A: Components (4) to (9) are uniformly dissolved and mixed. B: Components (1) to (3) and (10) to (15) are uniformly dissolved and mixed. C: A was added to B and mixed to obtain a lotion. The lotion obtained in this manner was excellent in the effect of preventing slippage due to aggregation of polymers, and in that it was neither sticky nor slimy when used.

[0052] Example 19: Cosmetic serum (Component) (%) (1) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.1 (2) Yubikaren 0.03 (3)Fragrance 0.1 (4) Tocopherol 0.1 (5) Ethanol 1.0 (6) Phenoxyethanol 0.2 (7) 1,3-butylene glycol (ingredient (E)) 5.0 (8) Glycerin (ingredient (E)) 5.0 (9) Diglycerin (ingredient (E)) 2.0 (10) Polyoxybutylene polyoxyethylene polyoxypropylene Glyceryl Ether (3E.O.) Note 6 3.0 (11) Carrageenan (ingredient (B)) Note 1 0.7 (12) Xanthan gum 0.2 (13) Hydroxyethyl cellulose (component (C)) Note 3 0.05 (14) Sodium carboxymethylcellulose (ingredient (C)) Note 4 0.02 (15) Methylparaben 0.2 (16) Magnesium ascorbyl phosphate (ingredient (A)) 0.1 (17) Disodium ascorbyl sulfate (ingredient (A)) 0.1 (18) L-Ascorbic acid 2-glucoside (component (A)) 1.5 (19) Remaining purified water Note 6: Wilbride S-753D (NOF Corporation)

[0053] (Manufacturing method) A: Components (1) to (6) are uniformly dissolved and mixed. B: Components (7) to (19) are uniformly dissolved and mixed. C: A was added to B and mixed to obtain a beauty serum. The beauty serum obtained in this manner was excellent in the effect of preventing creasing due to aggregation of polymers, and in that it was neither sticky nor slimy when used.

[0054] Example 20: Sheet-type beauty serum (Component) (%) (1) Polyoxyethylene isostearate (50) Hydrogenated castor oil 0.2 (2) Isostearic acid 0.03 (3) Ethyl oleate 0.02 (4)Fragrance 0.1 (5) Tocopherol 0.1 (6) Ethanol 1.0 (7) 1,3-butylene glycol (ingredient (E)) 5.0 (8) Glycerin (ingredient (E)) 6.0 (9) Diglycerin (ingredient (E)) 2.0 (10) Sorbitol (ingredient (E)) 0.5 (11) Polyethylene glycol (component (E)) 2.0 (12) Carrageenan (ingredient (B)) Note 1 0.5 (13) Hydroxyethyl cellulose (component (C)) Note 3 0.1 (14) Sodium carboxymethylcellulose (ingredient (C)) Note 4 0.1 (15) Tripropylene glycol (ingredient (E)) 2.5 (16) Dipropylene glycol (ingredient (E)) 1.5 (17) Niacinamide (ingredient (A)) 2.0 (18) Tranexamic acid (ingredient (A)) 2.0 (19) Sodium hydrogen phosphate (ingredient (A)) 0.2 (20) Sodium dihydrogen phosphate (ingredient (A)) 0.2 (21) Disodium edetate 0.02 (22) Methylparaben 0.1 (23) Carboxyvinyl polymer 0.02 (24) (Acrylates / C10-30 alkyl acrylate) Crosspolymer 0.02 (25) Sodium hydroxide 0.01 (26) Magnesium ascorbyl phosphate (ingredient (A)) 0.2 (27) Disodium ascorbyl sulfate (ingredient (A)) 0.2 (28) Remaining purified water

[0055] (Manufacturing method) A: Components (1) to (6) are uniformly dissolved and mixed. B: Components (7) to (28) are uniformly dissolved and mixed. C: After adding and mixing A to B, 30 mL of the mixture was impregnated into a nonwoven fabric (cellulose) to obtain a sheet-type beauty serum. The sheet-form beauty serum obtained in this manner was excellent in preventing creasing due to aggregation of polymers, and was also free from stickiness and sliminess during use.

[0056] Example 21: Oil-in-water emulsion (Component) (%) (1) 1,3-butylene glycol (ingredient (E)) 4.0 (2) Dipropylene glycol (ingredient (E)) 4.0 (3) Hydrogenated soybean phospholipid Note 7 0.2 (4) Polyoxyethylene sorbitan monooleate (20E.O.) 1.5 (5) Cetostearyl alcohol 0.5 (6) Behenyl alcohol 1.0 (7) Macadamia nut oil fatty acid phytosteryl Note 8 0.3 (8) Cetyl ethylhexanoate 0.2 (9) Natural Vitamin E 0.01 (10) (Sodium acrylate / sodium acryloyldimethyltaurate) Copolymer Note 9 0.5 (11) Glycerin (ingredient (E)) 5.5 (12) L-Ascorbic acid 2-glucoside (ingredient (A)) 4.0 (13) Carrageenan (ingredient (B)) Note 1 0.7 (14) Hydroxyethylcellulose (Component (C)) Note 3 0.4 (15) Sodium carboxymethylcellulose (ingredient (C)) Note 4 0.3 (16) Remaining purified water (17)Fragrance 0.1 (18) Ethanol 5.0 Note 7: PRESOME CS II-101 (manufactured by Nippon Fine Chemical Co., Ltd.) Note 8: PLANDOOL-MAS (manufactured by Nippon Fine Chemicals Co., Ltd.) *9: SIMULGEL EG QD (SEPPIC)

[0057] (Manufacturing method) A: Components (1) to (9) are uniformly dissolved and mixed at 75°C. B: Components (10) to (16) are uniformly dissolved and mixed at 75°C. C: Add B to A and emulsify. D: Dissolve and mix ingredients (17) and (18). E: After cooling C to 40°C, D was added and mixed to obtain an oil-in-water emulsion. The oil-in-water emulsion obtained in this manner was excellent in the effect of preventing slippage due to aggregation of polymers, and in that it was neither sticky nor slimy during use.

Claims

1. The following components (A) to (D): (A) Electrolyte 0.01-5% by mass (B) Carrageenan 0.1 to 1% by mass (C) Water-soluble cellulose ether 0.01 to 1% by mass (D) Water Contains the component (A) is a water-soluble ascorbic acid and / or a glycyrrhizinate, the water-soluble ascorbic acid is at least one selected from the group consisting of ascorbic acid, ascorbic acid phosphate, ascorbic acid sulfate, ascorbic acid glucoside, and their metal salts (sodium, potassium, magnesium, calcium), and the glycyrrhizinate is dipotassium glycyrrhizinate, The component (B) carrageenan is at least one selected from the group consisting of iota-type carrageenan and kappa-type carrageenan, A skin external preparation in which the mass ratio (C) / (B) of the components (B) and (C) is 0.01 to 0.

8.

2. The topical skin preparation according to claim 1, wherein the total content of the component (B) and the component (C) in the topical skin preparation is 0.1 to 1.5% by mass.

3. 3. The external skin preparation according to claim 1, wherein the component (C) is one or more selected from the group consisting of hydroxyethyl cellulose, carboxymethyl cellulose, and hydroxypropyl methyl cellulose.

4. The external skin preparation according to any one of claims 1 to 3, wherein the mass ratio of the components (A) to (C), [(A) + (B)] / (C), is 1 to 300.

5. 5. The external skin preparation according to claim 1, wherein the component (C) is a combination of hydroxyethyl cellulose and carboxymethyl cellulose.

6. The topical skin preparation according to any one of claims 1 to 5, further comprising 10 to 30% by mass of a polyhydric alcohol as component (E), and the content of glycerin in the polyhydric alcohol as component (E) is 20% by mass or more.

7. The external skin preparation according to any one of claims 1 to 6, wherein the content of (C) is 0.01 to 0.5% by mass.

8. The sheet-type external skin preparation according to any one of claims 1 to 7, characterized in that it is used by being applied to or impregnated into a sheet material.

9. The external skin preparation according to any one of claims 1 to 8, wherein the external skin preparation is a polymer aggregation inhibitor.

10. A method for inhibiting polymer aggregation, which uses the topical skin preparation according to any one of claims 1 to 9.

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