Dialysis fluid extraction device and blood purification device

Abstract

To provide a dialysis solution take-out device and a blood purification device which can more surely prevent scattering of a dialysis solution when detaching a cap member from a collection port.SOLUTION: A dialysis solution take-out device comprises: a dialysis solution take-out port 14 which is formed with a collection port 14a that can collect a dialysis solution; a cap member 15 which can be detachably attached to the collection port 14a of the dialysis solution take-out port 14; and a seal member 16 which seals the collection port 14a in such a state that the cap member 15 is attached to the collection port 14a. The seal member 16 comprises: a close-contact part 16a which is in close-contact with the outer peripheral surface of the dialysis solution take-out port 14 to seal the collection port 14a; and a protruding part 16b which is formed so as to protrude toward the inside of the collection port 14a, in which a gap is formed while the outer peripheral surface 16ba is opposed to the inner peripheral surface 14aa of the collection port 14a and which has an inflow path γ for allowing inflow of the air from the outside when the sealing by the close-contact part 16a is opened.SELECTED DRAWING: Figure 5

Description

[Technical Field]

[0001] The present invention relates to a dialysate withdrawal device and a blood purification device that include a cap member that is detachable from a sampling port of a dialysate withdrawal port connected to a dialysate flow path, and a seal member that seals the sampling port when the cap member is attached to the sampling port. [Background technology]

[0002] As disclosed in Patent Document 1, for example, a conventional dialysate withdrawal device includes a cap member that can be attached and detached to a sampling port of a dialysate withdrawal port connected to a dialysate flow path, and a sealing member that seals the sampling port when the cap member is attached to the sampling port. By removing the cap member from the sampling port, the sampling port is opened and the dialysate can be discharged to the outside. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2016-10477 Summary of the Invention [Problem to be solved by the invention]

[0004] However, in the above-mentioned conventional dialysate extraction device, although the sealing member bends and displaces toward the sampling port, thereby preventing the dialysis fluid from scattering when the cap member is removed, the tension of the liquid, such as cleaning fluid, may cause the liquid to adhere firmly to the tip of the dialysis fluid extraction port and remain. In such cases, the remaining dialysis fluid may scatter to the outside when the cap member is removed.

[0005] The present invention has been made in consideration of the above circumstances, and aims to provide a dialysate withdrawal device and a blood purification device that can more reliably prevent the dialysis fluid from splashing when the cap member is removed from the sampling port. [Means for solving the problem]

[0006] In one embodiment of the present invention Dialysate extraction device The dialysate extraction port is connected to a dialysate flow path through which dialysate flows, and is formed with a collection port through which dialysate flowing in the dialysate flow path can be collected; a cap member that is detachable from the collection port of the dialysate extraction port; and a seal member that is attached to the cap member and seals the collection port when the cap member is attached to the collection port. The seal member has a contact portion that contacts an outer peripheral surface of the dialysate extraction port to seal the collection port, and a protrusion that is formed to protrude toward the inside of the collection port, and whose outer peripheral surface faces an inner peripheral surface of the dialysate extraction port to form a gap, and that forms an inflow path through which air flows in from the outside when the seal formed by the contact portion is released. The protrusions are asymmetric in the vertical direction, with the protrusion dimension at the bottom being larger than the protrusion dimension at the top. . [Effects of the Invention]

[0007] According to the present invention, the sealing member has a contact portion that contacts the outer peripheral surface of the dialysis fluid extraction port to seal the sampling port, and a protruding portion that protrudes toward the inside of the sampling port and whose outer peripheral surface faces the inner peripheral surface of the sampling port to form a gap, thereby forming an inlet path that allows air to flow in from the outside when the seal made by the contact portion is released, thereby reliably preventing liquid from splashing when the cap member is removed from the sampling port. [Brief explanation of the drawings]

[0008] [Figure 1] 1 is a schematic diagram showing a blood purification device to which the dialysate withdrawal device of the present invention is applied; [Figure 2] FIG. 1 is a perspective view showing a dialysate withdrawal device according to an embodiment of the present invention. [Figure 3] Three-dimensional view of the dialysis fluid extraction device [Figure 4] Cross section of line IV-IV in Figure 3 [Figure 5] Cross section of line VV in Figure 3 [Figure 6] Cross section of line VI-VI in Figure 3 [Figure 7] Cross section of line VII-VII in Figure 3 [Figure 8] 1 is an exploded perspective view of the dialysate withdrawal port of the dialysate withdrawal device, the dialysate withdrawal port, the cap member, and the seal member, as viewed from above; FIG. [Figure 9] 1 is an exploded perspective view showing the collection port, cap member, and seal member of the dialysate withdrawal port of the dialysate withdrawal device from below. [Figure 10] 5A and 5B are views showing a sealing member in the dialysate withdrawal device; [Figure 11] 5A and 5B are views showing a cap member in the dialysate withdrawal device; [Figure 12] Schematic diagram showing the flow of liquid in the dialysate withdrawal device. [Figure 13] FIG. 10 is a schematic diagram showing a state in which the seal formed by the tightly contacting portion of the seal member in the dialysate withdrawal device is released. [Figure 14] Schematic diagram showing the state in which the dialysate extraction device is attached to the dialysate flow path of the blood purification device (with the collection port in a closed state) [Figure 15] Schematic diagram showing the state in which the dialysate extraction device is attached to the dialysate flow path of the blood purification device (with the collection port in a closed state) [Figure 16] Schematic diagram showing the dialysate extraction device attached to the dialysate flow path of a blood purification device (with the sampling port open) [Figure 17] Schematic diagram showing a blood purification device (negative pressure by a pressure pump) to which the dialysate withdrawal device of the present invention is applied. [Figure 18] Schematic diagram showing a blood purification device (negative pressure by a water removal pump) to which the dialysate withdrawal device of the present invention is applied. [Figure 19] Schematic diagram showing a blood purification device (negative pressure by a double pump) to which the dialysate withdrawal device of the present invention is applied. DETAILED DESCRIPTION OF THE INVENTION

[0009] Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings. The dialysate withdrawal device according to this embodiment is installed in a blood purification apparatus used in blood purification treatment (hemodialysis treatment) and is capable of withdrawing dialysate. As shown in Fig. 1, the blood purification apparatus to which this device is applied is mainly composed of a blood circuit in which an arterial blood circuit 2 and a venous blood circuit 3 are connected to a dialyzer 1 (blood purifier), and a dialysis apparatus main body B having a dialysate inlet line L1 and a dialysate outlet line L2.

[0010] The dialyzer 1 is used to purify blood and is connected to an arterial blood circuit 2 and a venous blood circuit 3 that constitute a blood circuit via ports 1a and 1b, respectively, and to a dialysate inlet line L1 and a dialysate outlet line L2 via ports 1c and 1d, respectively. A blood pump 4 consisting of a peristaltic pump is disposed in the arterial blood circuit 2, and by driving the blood pump 4, a liquid such as blood can be sent through the blood circuit.

[0011] An arterial puncture needle a and a venous puncture needle b can be attached to the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3, respectively, and by driving the blood pump 4 while inserting the arterial puncture needle a and the venous puncture needle b into a patient, the patient's blood collected through the arterial puncture needle a is circulated extracorporeally through the blood circuit, purified and dehydrated in the dialyzer 1, and then returned to the patient through the venous puncture needle b. An air trap chamber 5 is connected to the arterial blood circuit 2 and a clamp means Va is provided at its tip, and an air trap chamber 6 is connected to the venous blood circuit 3 and a clamp means Vb is provided at its tip.

[0012] Furthermore, a duplex pump 7 is connected to the dialysate inlet line L1 and the dialysate outlet line L2 to supply dialysate adjusted to a predetermined concentration to the dialyzer 1 and to discharge the dialysate from the dialyzer 1. That is, the duplex pump 7 is disposed across the dialysate inlet line L1 and the dialysate outlet line L2, and is configured such that the dialysate is fed to the dialyzer 1 through the dialysate inlet line L1 and discharged through the dialysate outlet line L2 by driving the duplex pump 7.

[0013] In addition, filters 11 and 12 are connected to the dialysate introduction line L1, and the dialysate to be introduced into the dialyzer 1 can be filtered by the filters 11 and 12, and the flow path can be blocked or opened at any timing by the solenoid valves V1 and V7. Device A pressure detection sensor S1 capable of detecting the pressure in the flow path (fluid pressure in the flow path) is connected between the dialysate inlet line L1 and the dialysate outlet line L2 via bypass lines L7 and L8, and solenoid valves V3 and V4 are connected to these bypass lines L7 and L8, respectively.

[0014] Additionally, bypass lines L3 and L4 that bypass the duplex pump 7 are connected to the dialysate discharge line L2, and a water removal pump 8 is connected to the bypass line L3. As a result, by driving the water removal pump 8 during the extracorporeal circulation of the patient's blood in the blood circuit, water can be removed from the blood flowing through the dialyzer 1. Furthermore, a pressure pump 9 consisting of a cascade pump is connected to the dialysate discharge line L2 upstream of the duplex pump 7 (left side in the figure), allowing the fluid pressure of the dialysate discharge line L2 at the duplex pump 7 (solution pump) to be adjusted. Note that a bypass line L5 extends from between the pressure pump 9 and the duplex pump 7 via a chamber 13.

[0015] A pressure detection sensor S2 capable of detecting the pressure in the flow path (fluid pressure in the flow path) is connected downstream of the solenoid valve V2 in the dialysate discharge line L2 (between the connection part of the bypass line L7 and the connection part of the bypass line L8). Furthermore, solenoid valves V2, V5, and V6 are connected to the dialysate discharge line L2 and the detour lines L4 and L5 branching therefrom, so that the flow paths can be blocked or opened at any timing. A detour line L6 is installed between the connection part of the dialysate discharge line L2 with the pressure pump 9 and the detour line L3, and a relief valve VL is connected to the detour line L6.

[0016] The dialysate supply line La has one end connected to the dialysate outlet. Device The dialysate supply line La is connected to the sampling port 14a of the dialysate outlet port 14 of the venous blood circuit 10, and the other end is connected to a blood circuit (in this embodiment, the air trap chamber 6 connected to the venous blood circuit 3), and is configured as a flow path that can supply the dialysate of the dialysate introduction line L1 to the blood circuit. A clamp means Vc is connected to this dialysate supply line La, and the clamp means Vc can be opened and closed at any timing. In this embodiment, the other end of the dialysate supply line La is connected to the air trap chamber 6, but it may also be connected to another part of the blood circuit (for example, the air trap chamber 5 connected to the arterial blood circuit 2).

[0017] Furthermore, the dialysate introduction line L1 according to this embodiment is connected to a dialysate withdrawal device 10 capable of collecting dialysate flowing through the dialysate introduction line L1. As shown in Figures 8, 9, and 14 to 16, this dialysate withdrawal device 10 is connected to the dialysate flow path (dialysate introduction line L1) and is configured to include a dialysate withdrawal port 14 having a collection port 14a formed therein through which the flowing dialysate can be collected, a cap member 15 that is detachable from the collection port 14a of the dialysate withdrawal port 14, and a seal member 16 that is attached to the cap member 15 and seals the collection port 14a when the cap member 15 is attached to the collection port 14a. As shown in Figures 4 and 5, the dialysate withdrawal device 10 is fixed to the dialysis device main body B with the axis (longitudinal direction) of the dialysate withdrawal port 14 (collection port portion 14a) facing horizontally. However, in consideration of operability, the dialysate withdrawal device 10 may be fixed to the dialysis device main body B with the axis (longitudinal direction) of the dialysate withdrawal port 14 (collection port portion 14a) tilted at a predetermined angle from the horizontal.

[0018] The dialysate outlet port 14 is configured to include a sampling port 14a through which dialysate can be sampled from the dialysate inlet line L1, a first sampling member 14b connected to the dialysate inlet line L1, a second sampling member 14c formed within the first sampling member 14b, and a third sampling member 14d assembled to the second sampling member 14c and having a flow path formed therein. As shown in Figures 4 and 5, the sampling port 14a is configured to include an inner circumferential surface 14aa and a protruding end 14ab, through which a connector (not shown) formed at one end of the dialysate supply line La (see Figure 1) can be inserted, and the inner circumferential surface 14aa is formed with a female thread portion 14ac into which the connector can be screwed.

[0019] Meanwhile, an inlet port T1 and an outlet port T2 are formed in the first outlet member 14b of the dialysate outlet port 14 according to this embodiment, and an inlet end L1a and an outlet end L1b of the dialysate introduction line L1 are connected to the inlet port T1 and the outlet port T2, respectively. A liquid flow path communicating with the inlet port T1 is formed inside the second outlet member 14c and the third outlet member 14d, and a check valve 18 is disposed in the flow path. The check valve 18 allows the liquid to flow from the dialysate supply line La toward the blood circuit, and blocks the liquid from flowing from the blood circuit toward the dialysate introduction line L1.

[0020] The tip of the third extraction member 14d opens into the collection port portion 14a, so that the liquid that has flowed through the internal flow paths of the second extraction member 14c and the third extraction member 14d reaches the collection port portion 14a. This forms a first flow path α (see FIGS. 4, 5, and 7) that allows the liquid (cleaning solution, disinfectant, etc.) flowing through the dialysate introduction line L1 to flow toward the collection port portion 14a. A gap of a predetermined dimension is provided between the outer peripheral surface of the third extraction member 14d and the inner peripheral surface of the collection port portion 14a, so that a second flow path β (see FIGS. 4, 5, and 7) that allows the liquid that has flowed through the first flow path α to flow toward the dialysate introduction line L1 when the cap member 15 is closed.

[0021] That is, when the cap member 15 is removed from the dialysate extraction port 14 (see Figure 16), the dialysate introduced from the introduction port T1 is discharged from the collection port portion 14a via the first flow path α and supplied to the blood circuit via the dialysate supply line La, and when the cap member 15 is attached to the dialysate extraction port 14 (see Figures 14 and 15), the dialysate introduced via the first flow path α flows into the second flow path β and returns to the dialysate introduction line L1 via the outlet port T2.

[0022] 14 to 16, the cap member 15 according to this embodiment is held by a lid member H attached to a vertically movable shaft member 17, and by lifting the lid member H upward, the cap member 15 is removed from the sampling port 14a of the dialysate withdrawal port 14 as shown in Fig. 16, and by pulling the lid member H downward, the cap member 15 is attached to the sampling port 14a of the dialysate withdrawal port 14 as shown in Figs. 14 and 15. Note that the symbol R in the drawings denotes a locking member that locks the lid member H in a state in which the cap member 15 is attached to the dialysate withdrawal port 14.

[0023] 2 to 7, the sealing member 16 is attached to the internal space of the cap member 15 to form an integral part, and is configured to cover and seal the opening of the sampling port 14a when the cap member 15 is attached to the sampling port 14a. The sealing portion 16a is made of a part that comes into close contact with the outer peripheral surface of the sampling port 14a in the dialysate outlet port 14 to seal (hermetically seal) the sampling port 14a.

[0024] This sealing member 16 prevents the dialysis fluid flowing through the dialysis fluid introduction line L1 from leaking to the outside when the cap member 15 is attached to the sampling port portion 14a, and also allows the liquid such as cleaning fluid or disinfectant flowing through the dialysis fluid introduction line L1 to reach the tip 14ab of the sampling port portion 14a, thereby ensuring that the tip 14ab and its vicinity (such as the area facing the space between the contact portion 16a and the tip 14ab) can be reliably cleaned or disinfected.

[0025] As shown in Figures 4 to 6, the sealing member 16 according to this embodiment has a protruding portion 16b formed to protrude toward the inside of the sampling port portion 14a. ba is configured to face the inner circumferential surface 14aa of the sampling port portion 14a and form a gap, and to form an inflow channel γ through which air flows in from the outside when the seal by the contact portion 16a is released.

[0026] More specifically, as shown in Fig. 13, protrusion 16b according to this embodiment is configured so that tip 16bb is located inside sampling port 14a (left side in Fig. 13) relative to position P1 of contact portion 16a when the seal of sampling port 14a is opened, and inflow channel γ is maintained when the seal is opened. This inflow channel γ is formed over the entire circumferential area of ​​outer peripheral surface 16ba of protrusion 16b, as shown in Fig. 6.

[0027] As a result, when the seal is released by the contact portion 16a reaching the position P1 during the process of removing the cap member 15 from the sampling port portion 14a, the outside air flows into the sampling port portion 14a at a high flow rate through the inflow channel γ, and the liquid adhering to the vicinity of the tip 14ab of the sampling port portion 14a can be prevented from overflowing to the outside. Department As the volume inside 14a increases and the internal pressure decreases, when the seal portion 16a reaches position P1 and the seal is released, external air flows in forcefully through the inflow channel γ and enters the sampling port together with the liquid adhering to the tip 14ab of the sampling port portion 14a. Department It flows into 14a.

[0028] Furthermore, the protruding portion 16b according to this embodiment has a protruding shape that is asymmetric in the up-down direction, with the protruding dimension of the lower portion being larger than the protruding dimension of the upper portion, as shown in Fig. 12. That is, in this embodiment, the dialysate withdrawal device 10 is fixed with the axis (longitudinal direction) of the dialysate withdrawal port 14 (sampling port portion 14a) facing horizontally, and when the protruding portion 16b is viewed from the side, the protruding dimension of the lower portion is larger than the protruding dimension of the upper portion.

[0029] As a result, the tip 16bb of the protrusion 16b forms a surface that slopes downward, and a liquid such as a cleaning solution or a disinfectant that is discharged to the protrusion 16b through the first flow path α flows obliquely upward along the tip 16bb to reach the upper side of the inflow path γ and then flows in the circumferential direction of the outer peripheral surface 16ba of the protrusion 16b. The liquid such as a cleaning solution or a disinfectant that has flowed in the circumferential direction of the outer peripheral surface 16ba of the protrusion 16b then passes through the lower side of the inflow path γ to reach the second flow path β and flows to the dialysis fluid introduction line L1.

[0030] However, the liquid adhering to protrusion 16b will accumulate under its own weight at the bottom of protrusion 16b. In contrast, protrusion 16b according to this embodiment has a shape in which the protrusion dimension of the bottom is greater than the protrusion dimension of the top, and therefore inflow channel γ formed on the bottom side of protrusion 16b is formed long, and the liquid that has accumulated under its own weight at the bottom of protrusion 16b can flow into sampling port 14a together with external air.

[0031] Furthermore, the cap member 15 according to this embodiment has a positioning portion 15a that can position the seal member 16, as shown in FIG. Materials 15 has a positioning portion 15a formed in a notch shape at a predetermined position, and a seal Materials 10, the positioning portion 15a has a protrusion 16 that can be fitted into the positioning portion 15a. c is formed, and the protrusion 16 c The seal member 16 can be positioned by fitting it into the positioning portion 15a and attaching it to the cap member 15.

[0032] In addition, the blood purification device applied to this embodiment is configured to create a negative pressure inside the dialysate outlet port 14 at a predetermined timing before the cap member 15 is removed from the sampling port 14a. An example of a means for creating a negative pressure inside the dialysate outlet port 14 is a fluid delivery unit that delivers the dialysate through the dialysate introduction line L1 (dialysate flow path). In this embodiment, the pressure inside the dialysate outlet port 14 is created by driving the pressure pump 9, which is a cascade pump.

[0033] Next, a case where the pressure pump 9 is driven to create a negative pressure inside the dialysate outlet port 14 will be described below with reference to FIG. First, the tip c of the dialysate inlet line L1 is connected to the tip d of the dialysate outlet line L2, and the solenoid valves V1, V2, V4, V5, and V7 are closed (blocking the flow path), and the solenoid valves V3 and V6 are opened (opening the flow path), and the pressure pump 9 is driven. At this time, the ultrafiltration pump 8 and the duplex pump 7 are stopped. This allows the volume of the dialysate at the part of the dialysate inlet line L1 to which the dialysate take-out device 10 is connected to be reduced, and a negative pressure can be created inside the dialysate take-out port 14.

[0034] Thereafter, by closing the solenoid valves V1, V3, and V7, the negative pressure in the dialysate withdrawal device 10 can be maintained. In this state, for example, a display monitor or the like can be displayed to indicate that the negative pressure is being maintained, allowing the operator to remove the cap member 15 from the sampling port portion 14a. Note that, by opening the solenoid valve V4 while the negative pressure in the dialysate withdrawal device 10 is being maintained, the dialysate can be made to flow through the bypass line L8 when the duplex pump 7 is driven.

[0035] Furthermore, the ultrafiltration pump 8 can be driven to create a negative pressure inside the dialysate take-out port 14. In this case, as shown in Fig. 18, the tip c of the dialysate inlet line L1 is connected to the tip d of the dialysate outlet line L2, and the solenoid valves V1, V2, V4, V5, V6, and V7 are closed (blocking the flow path), and the solenoid valve V3 is opened (opening the flow path), and the ultrafiltration pump 8 is driven. This reduces the volume of the dialysate at the part of the dialysate inlet line L1 to which the dialysate take-out device 10 is connected, and creates a negative pressure inside the dialysate take-out port 14. In this state, by closing the solenoid valves V1, V3, and V7, the negative pressure of the dialysate take-out device 10 can be maintained.

[0036] Furthermore, the duplex pump 7 can be driven to create a negative pressure inside the dialysate take-out port 14. In this case, as shown in Fig. 19, the tip c of the dialysate inlet line L1 is connected to the tip d of the dialysate outlet line L2, and the solenoid valves V1, V2, V4, V5, V6, and V7 are closed (blocking the flow path), and the solenoid valve V3 is opened (opening the flow path), and the duplex pump 7 is driven. This reduces the volume of dialysate at the part of the dialysate inlet line L1 to which the dialysate take-out device 10 is connected, and creates a negative pressure inside the dialysate take-out port 14. In this state, by closing the solenoid valves V1, V3, and V7, the negative pressure of the dialysate take-out device 10 can be maintained.

[0037] According to this embodiment, the sealing member 16 has a contact portion 16a that contacts the outer peripheral surface of the dialysate extraction port 14 to seal the sampling port portion 14a, and a protruding portion 16b that protrudes toward the inside of the sampling port portion 14a, and whose outer peripheral surface 16ba faces the inner peripheral surface 14aa of the sampling port portion 14a to form a gap, thereby forming an inflow channel γ that allows air to flow in from the outside when the seal by the contact portion 16a is released, thereby reliably preventing liquid from splashing when the cap member 15 is removed from the sampling port portion 14a.

[0038] Furthermore, in the protrusion 16b according to this embodiment, the tip 16bb is positioned inside the collection port 14a relative to the position of the contact portion 16a when the seal of the collection port 14a is opened, and the inflow path γ is maintained when the seal is opened. inflow channel This makes it possible to reliably maintain γ, and more reliably prevent the liquid from splashing when the cap member 15 is removed from the sampling port portion 14a.

[0039] Furthermore, since inflow channel γ is formed over the entire circumferential area of ​​outer peripheral surface 16ba of protrusion 16b, liquid adhering to the vicinity of tip 14ab of sampling port 14a can be caused to flow into sampling port 14a together with air over the entire circumferential area. Furthermore, dialysate outlet port 14 includes first flow path α that causes liquid flowing through dialysate introduction line L1 to flow toward sampling port 14a, and second flow path β that causes liquid that has flowed through first flow path α to flow toward dialysate introduction line L1, and protrusion 16b has a protruding shape that is asymmetric in the vertical direction, with the protruding dimension of the lower portion being larger than the protruding dimension of the upper portion. Therefore, liquid such as a cleaning solution or a disinfectant solution that has been discharged to protrusion 16b through first flow path α can flow smoothly from second flow path β to dialysate introduction line L1.

[0040] In addition, the cap Materials 15 has a positioning portion 15a that can position the sealing member 16, so that the protruding portion 16b, which has an asymmetrical protruding shape in the vertical direction, can be reliably oriented in a predetermined direction, and the protruding portion 16b can be positioned with the part with the larger protruding dimension at the bottom and the part with the smaller protruding dimension at the top.

[0041] Furthermore, according to the blood purification device applied to this embodiment, negative pressure is created inside the dialysate outlet port 14 at a predetermined timing before the cap member 15 is removed from the sampling port 14a, thereby reliably preventing the liquid from splashing when the cap member 15 is removed from the sampling port 14a. However, according to this embodiment, negative pressure is created inside the dialysate outlet port 14 by driving the fluid delivery unit (pressurization pump 9, water removal pump 8, or duplex pump 7) that delivers the dialysate through the dialysate introducing line L1. This allows the use of components necessary for blood purification treatment, and in particular, by using the pressurization pump 9, which is a cascade pump, as the fluid delivery unit to be driven, a constant volume can be gradually reduced without pulsation, thereby smoothly generating negative pressure.

[0042] Although the present embodiment has been described above, the present invention is not limited thereto, and for example, as long as the present invention includes protrusion 16b that forms inflow channel γ through which air flows in from the outside when the seal of sealing portion 16a is released, protrusion 16b does not have to have an asymmetrical protrusion shape in the vertical direction, and may be, for example, a cylindrical protrusion (including hollow and solid ones). Furthermore, the blood purification device to which the present invention is applied is not limited to one that creates a negative pressure inside dialysate withdrawal port 14 at a predetermined timing before cap member 15 is removed from sampling port 14a, and may be one that does not have this function.

[0043] The blood purification device to which this embodiment is applied may be of any type, for example, one in which the dialysate is introduced or discharged by a chamber instead of the duplex pump 7, one equipped with another type of blood purifier instead of the dialyzer 1, or one not equipped with the pressure detection means S1, S2, etc. Furthermore, in this embodiment, both are disposed in the dialysate introduction line L1 of the dialysis device main body, but they may also be disposed in other dialysate flow paths within the dialysis device main body. [Industrial Applicability]

[0044] The present invention can also be applied to devices with different external shapes or devices with additional functions, provided that they have the same gist as the present invention. [Explanation of symbols]

[0045] 1 Dialyzer (blood purifier) 2 Arterial blood circuit 3 Venous blood circuit 4. Blood pump 5. Arterial Air Trap Chamber 6. Venous Air Trap Chamber 7. Duplex Pump 8 Water removal pump 9. Pressure pump (cascade pump) 10 Dialysate extraction device 11, 12 Filter 13 Chamber 14 Dialysis fluid outlet port 14a Sampling port 14aa inner surface 14ab tip 14ac female thread 14b First extraction member 14c Second extraction member 14d Third extraction member 15 Cap member 15a Positioning part 16 Sealing material 16a Adhesion part 16b Protrusion 16ba outer surface 16bb tip 16c Convex part 17 Shaft member 18 Check valve L1 Dialysis fluid introduction line (dialysis fluid flow path) L2 Dialysis fluid drain line B Dialysis machine body H Cover member S1, S2 pressure detection sensors α 1st flow path β Second flow path γ inflow path

Claims

1. a dialysate extraction port connected to a dialysate flow path through which a dialysate flows, the dialysate extraction port having a sampling port through which the dialysate flowing in the dialysate flow path can be sampled; a cap member detachable from the sampling port of the dialysate extraction port; a seal member attached to the cap member and sealing the sampling port portion when the cap member is attached to the sampling port portion; Equipped with The sealing member is a contact portion that seals the sampling port by contacting with an outer peripheral surface of the dialysate outlet port; a protrusion formed to protrude toward the inside of the sampling port portion, with its outer peripheral surface facing the inner peripheral surface of the sampling port portion to form a gap, and forming an inflow path through which air flows in from the outside when the seal formed by the tightly contacting portion is opened; wherein the protrusion has a protruding shape that is asymmetric in the vertical direction, and the protruding dimension of the lower part is greater than the protruding dimension of the upper part.

2. 2. The dialysate withdrawal device according to claim 1, wherein the tip of the protrusion is positioned inside the collection port portion relative to the position of the sealing portion when the seal of the collection port portion is opened, and the inflow path is maintained when the seal is opened.

3. 3. The dialysate withdrawal device according to claim 1, wherein the inflow channel is formed over the entire circumferential area of ​​the outer circumferential surface of the protrusion.

4. 4. The dialysate withdrawal device according to claim 3, wherein the dialysate withdrawal port comprises a first flow path that causes the liquid flowing through the dialysate flow path to flow toward the collection port, and a second flow path that causes the liquid that has flowed through the first flow path to flow toward the dialysate flow path.

5. 5. The dialysate withdrawal device according to claim 4, wherein the cap member has a positioning portion that can position the seal member.

6. A blood purification apparatus including the dialysate flow path to which the dialysate withdrawal device according to any one of claims 1 to 5 is attached, A blood purification apparatus in which the inside of the dialysate withdrawal port is made negative pressure at a predetermined timing before the cap member is removed from the sampling port.

7. 7. The blood purification apparatus according to claim 6, further comprising a fluid delivery section for delivering the dialysate through the dialysate flow path, and driving the fluid delivery section to create a negative pressure inside the dialysate outlet port.

8. 8. The blood purification apparatus according to claim 7, wherein the liquid delivery unit comprises a cascade pump.

9. A dialysate extraction port connected to a dialysate flow path through which a dialysate flows, the dialysate extraction port having a sampling port through which the dialysate flowing in the dialysate flow path can be sampled; a cap member detachable from the sampling port of the dialysate extraction port; a seal member attached to the cap member and sealing the sampling port portion when the cap member is attached to the sampling port portion; Equipped with The sealing member is a contact portion that seals the sampling port by contacting with an outer peripheral surface of the dialysate outlet port; a protrusion formed to protrude toward the inside of the sampling port portion, with its outer peripheral surface facing the inner peripheral surface of the sampling port portion to form a gap, and forming an inflow path through which air flows in from the outside when the seal formed by the tightly contacting portion is opened; the contact portion and the protruding portion are formed as parts of the sealing member, and the protruding portion has a tip that forms a sloped surface, and when the sealing member seals the collection port portion, the dialysate collected from the collection port portion flows along the tip and reaches the gap formed between the tip and an inner peripheral surface of the collection port portion.

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