Topical Compositions

Abstract

The present invention relates to a topical composition comprising an isomerized sugar syrup, a polysiloxane-based UV filter, and ultrafine zinc oxide, as well as the use of an isomerized sugar syrup to reduce the stickiness of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide.

Description

Detailed Description of the Invention

[0001] The present invention relates to a topical composition comprising an isomerized sugar syrup, a polysiloxane-based UV filter, and ultrafine zinc oxide, and to the use of an isomerized sugar syrup to reduce the stickiness of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide.

[0002] It is well known that ultraviolet (UV) rays from sunlight have damaging effects on the skin. In addition to the well-known acute damage (sunburn), there is also long-term damage, such as an increased risk of developing skin cancer. Furthermore, exposure to UV rays is responsible for most of the wrinkles and age spots on our faces. Therefore, a series of photoprotective UV filter substances have been developed that can be incorporated into topical sunscreen formulations to protect the skin from the harmful effects of UV rays.

[0003] Modern sunscreens must effectively and safely protect skin from the harmful effects of UV rays. Therefore, sunscreens typically contain various UV-B (wavelength: 280-320 nm) and UV-A (wavelength: 320-400 nm) filters. However, these filters often make the sunscreen sticky, which means that sand can stick to areas of the skin where the cream is applied, especially when used at the beach. The higher the UV filter content of the formulation, the greater this problem. To address the stickiness issue, consumers tend to use less sunscreen, which leads to inadequate protection.

[0004] Although there has been no lack of attempts to develop sunscreen compositions with reduced tack, the problem has yet to be solved to ultimate satisfaction.

[0005] Therefore, there is a continuing need to develop new sunscreen formulations that have reduced tackiness.

[0006] Surprisingly, it has now been found that the addition of isomerized sugar to a sunscreen composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide results in a significant reduction in tackiness.

[0007] Thus, in a first aspect, the present invention relates to a topical composition comprising high fructose corn syrup, a polysiloxane-based UV filter, and ultrafine zinc oxide.

[0008] The term "topical" as used herein is understood here to mean external application to keratinous materials, in particular the skin, scalp, eyelashes, eyebrows, nails, mucous membranes and hair, preferably human skin.

[0009] High-fructose corn syrup (CAS 100843-69-4) is a well-known cosmetic agent with a unique skin binding mechanism used for short-term and long-term moisturization. High-fructose corn syrup is commercially available, for example, under the trademarks PENTAVITIN® from DSM Nutritional Products Ltd or Hyanify from Lipotec. In all embodiments of the present invention, the most preferred high-fructose corn syrup is PENTAVITIN®, which contains, as an active ingredient, an high-fructose corn syrup consisting essentially of glucose, fructose mannose, and galactose.

[0010] The amount of high fructose corn syrup in the topical composition according to the present invention is preferably in the range of 0.01 to 10% by weight, more preferably in the range of 0.1 to 7.5% by weight, and most preferably in the range of 0.2 to 5% by weight, based on the total weight of the topical composition. Further suitable ranges are 0.25 to 2.5% by weight and 0.5 to 2% by weight.

[0011] According to a further embodiment, the polysiloxane-based UV filter in the topical composition has a chromophore residue of the benzalmalonate type.

[0012] According to a further embodiment, the polysiloxane-based UV filter in the topical composition is a compound according to formula Ia or Ib: [ka] (In the formula, X is R or A; A is of formula IIa, IIb or IIc: [ka] is selected from R is hydrogen, C 1~6 - alkyl or phenyl, R 1 and R 2 are each independently hydrogen, hydroxy, or C 1~6 -alkyl or C 1~6 -alkoxy, R 3 is C 1~6 -alkyl, R 4 is hydrogen or C 1~6 -alkyl, R 5 and R 6 are each independently hydrogen or C 1~6 -alkyl, r is 0 to 250; s is 0 to 20, r+s is at least 3, t is between 0 and 10, v is between 0 and 10; v+t is at least 3, n is 1 to 6; However, if s is 0, then at least one X is A).

[0013] "C 1~6 The term "C-alkyl" refers to groups such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, isobutyl, pentyl, and neopentyl. 1~6 The term "-alkoxy" refers to the corresponding alkoxy group.

[0014] In all embodiments of the present invention, R is preferably methyl.

[0015] residue R 1 and R 2 is preferably hydrogen, methoxy or ethoxy, more preferably hydrogen, or R 1 and R 2 One of the groups is hydrogen and the other is methyl, methoxy, or ethoxy.

[0016] residue R 3 is preferably methyl or ethyl, more preferably ethyl.

[0017] Preferably, R 4 is hydrogen or methyl, and R 5 and R 6 is hydrogen and n is 1.

[0018] Polysiloxane compounds having a group A of the general formula IIa and IIb and their formulation are described in EP-A-0 538 431. These polysiloxane compounds are most preferred.

[0019] Polysiloxane compounds having a group A of the general formula IIc and their formulations are described in EP-A-0 358 584.

[0020] In the linear polysiloxane compounds according to formula Ia, the chromophores bearing residue A can be attached to the end groups of the polysiloxane (X=A) or can be distributed statistically throughout the polymer.

[0021] A linear polysiloxane compound in which chromophores having a residue A are statistically distributed is preferred. The aforementioned preferred polysiloxane compound has at least one unit having a chromophore residue (s=1), and preferably, s has a value of about 2 to about 10, more preferably, a statistical average of about 4. The number r of other silicone units present in the polysiloxane compound is preferably about 5 to about 150, more preferably, a statistical average of about 60.

[0022] Polysiloxane compounds in which not more than 20%, preferably less than 10%, of the total siloxane units are units having chromophore residues are preferred in terms of cosmetic properties.

[0023] The ratio of polysiloxane units having chromophore residues A of formula IIa to those having chromophore residues A of formula IIb is not critical and can be from about 1:1 to about 19:1, preferably from about 2:1 to about 9:1, more preferably about 4:1.

[0024] Polysiloxane compounds Ia or Ib, where A is of formula IIa or IIb, can be prepared as described in EP 0538431 by silylation of the corresponding benzalmalonate according to the following reaction scheme: [ka] (In the formula, R 1 , R 2 and R 3 is as defined above).

[0025] Silylation of 4-(2-propynyloxy)phenylmethylene diethyl ester can be carried out using known procedures for adding silicon-bonded hydrogen atoms to groups containing aliphatic unsaturation. Such reactions are generally catalyzed by platinum group metals or complexes of such metals. Examples of catalysts that can be used include platinum on carbon, chloroplatinic acid, platinum acetylacetonate, complexes of platinum compounds with unsaturated compounds, such as olefins and divinyldisiloxanes, complexes of rhodium and palladium compounds, and complexes of platinum compounds supported on inorganic substrates. The addition reaction can be carried out at reduced pressure, atmospheric pressure, or elevated pressure. For example, a solvent, such as toluene or xylene, can be used in the reaction mixture, although the presence of a solvent is not required. It is also preferable to carry out the reaction at elevated reaction temperatures, such as from about 50°C to about 150°C.

[0026] Particularly preferred are compounds of the general formula Ia, wherein X means methyl; A represents a group of formula IIa or IIb, R means methyl; R 1 and R 2 means hydrogen, methoxy or ethoxy, or one or R 1 and R 2 is hydrogen and the other is methyl, methoxy, or ethoxy; R 3 means methyl or ethyl, R 4 means hydrogen or methyl, R 5 and R 6 means hydrogen, r is about 5 to 150, s is about 2 to about 10; n has a value of 1.

[0027] Most preferred are linear polysiloxanes of general formula Ia, wherein: X means methyl; A represents a group of formula IIa or IIb, R means methyl; R 1 and R 2 means hydrogen, R 3 means ethyl, R 4 means hydrogen, R 5 and R 6 means hydrogen, r is the statistical mean of approximately 60 s is the statistical mean of about 4, n has a value of 1.

[0028] The most preferred of these polysiloxane-based UV filters for all embodiments of the present invention is Polysilicone-15 (INCI), available commercially from DSM Nutritional Products Ltd. under the trade name PARSOL® SLX.

[0029] The amount of polysiloxane UV filter, in particular the amount of Polysilicone-15, in the composition according to the present invention is preferably selected in the range of 0.1 to 15 wt.%, for example in the range of 0.5 to 10 wt.%, for example, most preferably in the range of 1 to 5 wt.%, based on the total weight of the composition. More suitable ranges are 0.2 to 10 wt.%, 0.3 to 10 wt.%, or 0.4 to 10 wt.%.

[0030] The term ultrafine zinc oxide refers to any zinc oxide particles suitable for use as a UV filter, i.e., zinc oxide having a particle size primarily useful for incorporation into sunscreen compositions. Advantageously, ultrafine zinc oxide consists of particles having a primary particle size of less than about 300 nm, e.g., less than about 200 nm, or less than about 150 nm. Most preferably, in all embodiments of the present invention, the average particle size of the ultrafine zinc oxide according to the present invention is selected in the range of 50 to 200 nm, preferably in the range of 75 to 150 nm, and most preferably in the range of 90 to 130 nm.

[0031] As used herein, the term "average particle size" refers to the average numerical particle size distribution Dn50 (also known as Dn0.5), as determined by laser diffraction, for example, using a Horiba particle size distribution analyzer LA-960 or a Malvern Mastersizer2000 (ISO 13320:2009).

[0032] According to the present invention, it is also advantageous for the zinc oxide particles to be surface-coated. The surface coating may involve providing the metal oxide particles with a thin hydrophilic or hydrophobic inorganic or organic layer by methods known per se. According to the present invention, the various surface coatings may also contain water. As a result of the surface treatment, the metal oxide is endowed with hydrophilic, amphiphilic, or hydrophobic properties.

[0033] Examples of inorganic surface coatings suitable for the purposes of the present invention are aluminum oxide (Al2O3), aluminum hydroxide Al(OH)3, aluminum oxide hydrate (also: alumina, CAS number: 1333-84-2), sodium hexametaphosphate (NaPO3)6, sodium metaphosphate (NaPO3). n , silicon dioxide (SiO2) (also: silica, CAS number: 7631-86-9), and iron oxide (Fe2O3). These inorganic surface coatings may be present by themselves, in combination, and / or in combination with organic coating materials.

[0034] Examples of organic surface coatings suitable for use in the present invention include vegetable or animal-derived aluminum stearate, vegetable or animal-derived stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxane (methicone), simethicone (a mixture of dimethylpolysiloxane and silica gel having an average chain length of about 200 to about 350 dimethylsiloxane units), triethoxycaprylylsilane, and octyltrimethoxysilane. These organic surface coatings can be present alone, in combination, and / or in combination with inorganic coating materials. Preferably, the zinc oxide according to the present invention is uncoated or coated with dimethicone, methicone, or triethoxycaprylylsilane, and most preferably, the zinc oxide according to the present invention is surface-coated with triethoxycaprylylsilane.

[0035] Furthermore, the zinc oxide is preferably a white powder consisting of zinc oxide present in the wurtzite crystal structure.

[0036] Zinc oxide particles and pre-dispersions of zinc oxide particles for use according to the invention are available, for example from BASF as Z-Cote or Z-Cote HP1 (2% dimethicone coating), from Tayca as MZ-505S (5% methicone coating), or from DSM Nutritional Products Ltd as PARSOL® ZX (2-3.5% triethoxycaprylylsilane coating).

[0037] Most preferably, in all embodiments according to the present invention, the zinc oxide is a white powder consisting of zinc oxide present in the wurtzite crystalline structure, coated with triethoxycaprylylsilane, having a zinc oxide content of 96-98%, a triethoxycaprylylsilane content of 2-3.5%, and an average particle size of 90-130 nm.

[0038] In all embodiments of the present invention, the amount of ultrafine zinc oxide is preferably selected in the range of 0.1 wt. % to 20 wt. %, more preferably in the range of 0.5 wt. % to 15 wt. %, most preferably in the range of 1 wt. % to 10 wt. %, for example in the range of 5 wt. % to 10 wt. %, based on the total weight of the topical composition.

[0039] In another aspect, the present invention relates to a topical composition according to an embodiment described herein for use as a sunscreen, or the use of a topical composition according to an embodiment described herein as a sunscreen.

[0040] In yet another embodiment, the present invention relates to the use of high fructose corn syrup to reduce the stickiness of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide.

[0041] A further embodiment of the present invention relates to a method for reducing stickiness and / or sandiness on the skin of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide, said method comprising the step of incorporating high fructose corn syrup into said topical composition before applying said topical composition to the skin and optionally assessing the effect.

[0042] Since the topical compositions according to the invention are intended for topical application, it is well understood that they comprise a physiologically acceptable medium, i.e., a medium that is compatible with the skin, mucous membranes, and keratinous materials such as keratinous fibers. In particular, a physiologically acceptable medium is a cosmetically acceptable carrier.

[0043] As used herein, the term "cosmetically acceptable carrier" refers to any carrier and / or excipient and / or diluent conventionally used in topical cosmetic compositions, especially skin care formulations.

[0044] The topical composition according to the present invention is preferably prepared by mixing isomerized sugar syrup, polysiloxane-based UV filters, and extra-fine zinc oxide with a cosmetically acceptable carrier, with all the definitions and preferences set out herein.

[0045] The exact amount of carrier will depend on the actual levels of the isomerized sugar syrup, polysiloxane-based UV filters, and extra-fine zinc oxide, as well as any other optional ingredients (e.g., other active ingredients) that one of ordinary skill in the art would classify as different from a carrier.

[0046] In an advantageous embodiment, the cosmetic or pharmaceutical composition according to the invention comprises 50% to 99%, preferably 60% to 98%, more preferably 70% to 98%, for example in particular 80% to 95%, of a carrier, based on the total weight of the topical composition.

[0047] In a particularly advantageous embodiment, the carrier further comprises at least 40% by weight, more preferably at least 50% by weight, most preferably at least 55% by weight of water, such as in particular 55 to 90% by weight of water.

[0048] In particular, the topical composition according to the invention is a cosmetic or pharmaceutical composition, preferably a cosmetic (non-therapeutic) composition.

[0049] In one embodiment, the topical composition according to the invention is applied to mammalian keratinous tissue, in particular human skin or human scalp and hair.

[0050] The term "cosmetic composition" as used in this application refers to cosmetic compositions defined under the heading "Kosmetika" in Römpp Lexikon Chemie, 10th edition 1997, Georg Thieme Verlag Stuttgart, New York, and cosmetic compositions disclosed in A. Domsch, "Cosmetic Compositions", Verlag für chemische Industrie (ed. H. Ziolkowsky), 4th edition, 1992.

[0051] Preferred topical compositions according to the present invention are skin care formulations, decorative formulations, and functional formulations.

[0052] Examples of skin care formulations are, in particular, photoprotective formulations, anti-aging formulations, formulations for treating photoaging, body oils, body lotions, body gels, treatment creams, skin protective ointments, skin powders, moisturizing gels, moisturizing sprays, moisturizers for the face and / or body, tanning formulations (i.e. compositions for artificial / sunless tanning and / or browning of human skin), such as self-tanning creams, and skin whitening formulations.

[0053] Examples of decorative preparations are in particular lipsticks, eye shadows, mascaras, dry and wet make-up formulations, rouge and / or powders.

[0054] Examples of functional formulations are, but are not limited to, cosmetic or pharmaceutical compositions containing active ingredients such as hormone formulations, vitamin formulations, plant extract formulations, anti-aging formulations, and / or antimicrobial (antibacterial or antifungal) formulations.

[0055] In a particular embodiment, the topical composition according to the invention is a photoprotective preparation (sun care product) such as a sunscreen milk, a sunscreen lotion, a sunscreen cream, a sunscreen oil, a sunscreen or a tropical or day cream having an SPF (sun protection factor). Of particular interest are sunscreen creams, sunscreen lotions, sunscreen milks and sunscreen preparations.

[0056] The compositions of the present invention (including the carrier) may contain conventional adjuvants and additives such as preservatives / antioxidants, fatty substances / oils, organic solvents, silicones, thickeners, emollients, emulsifiers, antifoaming agents, aesthetic ingredients such as fragrances, surfactants, fillers, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifying or basifying agents, dyes, colorants / colorants, abrasives, absorbents, chelating and / or sequestrants, essential oils, skin sensates, astringents, pigments, or any other ingredient normally incorporated into such compositions.

[0057] According to the present invention, the composition according to the present invention may also contain additional cosmetic active ingredients conventionally used in cosmetic or pharmaceutical compositions. Exemplary active ingredients include UV filters, agents for preventing or reducing inflammation, stabilizers, moisturizers, soothing agents, and / or agents that provide energy, as well as agents that improve elasticity and the skin barrier.

[0058] Examples of cosmetic excipients, diluents, adjuvants, additives, and active ingredients commonly used in the skin care industry that are suitable for use in the cosmetic compositions of the present invention include, but are not limited to, those described in, for example, the International Cosmetic Ingredient Dictionary & Handbook by the Personal Care Product Council (http: / / www.personalcarecouncil.org / ), accessible from the online INFO BASE (http: / / online.personalcarecouncil.org / jsp / Home.jsp).

[0059] The required amounts of active ingredients and excipients, diluents, adjuvants, additives, etc. can be readily determined by one skilled in the art based on the desired product form and application. Additional ingredients can be added to the oily phase, the aqueous phase, or separately, as deemed appropriate.

[0060] The cosmetically active ingredients useful herein can act via one or more mechanisms of action, which in some cases can provide one or more benefits.

[0061] Naturally, the skilled person will take care to select the above-mentioned optional additional components, adjuvants, diluents and additives, and / or their amounts, such that the advantageous properties inherently associated with the combination according to the invention are not adversely affected, or are not substantially adversely affected, by one or more of the envisaged additions.

[0062] The topical compositions according to the invention may be in the form of suspensions or dispersions in solvents or fatty substances, or in the form of emulsions or microemulsions (in particular oil-in-water (O / W) or water-in-oil (W / O), silicone-in-water (Si / W) or water-in-silicone (W / Si), PIT-emulsions, multiple emulsions (for example oil-in-water-in-oil (O / W / O) or water-in-oil-in-water (W / O / W)), Pickering emulsions, hydrogels, alcoholic gels, lipogels, single- or multiphase solutions or vesicular dispersions, or other conventional forms that can be applied as a mask or spray, also by pen.

[0063] The topical composition according to the invention is advantageously in the form of an oil-in-water (O / W) emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O / W emulsifier. The preparation of such O / W emulsions is well known to those skilled in the art and is illustrated in the Examples.

[0064] In one advantageous embodiment, the O / W emulsifier is a phosphate ester emulsifier. The term phosphate ester emulsifier refers to a phosphate ester emulsifier of formula (II) [ka] (In the formula, R 5 , R 6 and R 7 may be hydrogen, an alkyl of 1 to 22 carbons, preferably 12 to 18 carbons, or an alkoxylated alkyl having 1 to 22 carbons, preferably 12 to 18 carbons, and having 1 or more, preferably 2 to 25, most preferably 2 to 12 moles of ethylene oxide, provided that: R 5 , R 6 and R 7 at least one of is an alkyl or alkoxylated alkyl as defined above, but having at least 6 alkyl carbons in said alkyl or alkoxylated alkyl group).

[0065] R 5 and R 6 is hydrogen and R 7 Among the preferred phosphate ester emulsifiers are monoesters selected from alkyl groups of 10 to 18 carbons and alkoxylated fatty alcohols of 10 to 18 carbons and 2 to 12 moles of ethylene oxide. 8~10 Alkyl ethyl phosphate, C 9~15 Alkyl phosphate, ceteareth-2 phosphate, ceteareth-5 phosphate, ceteth-8 phosphate, ceteth-10 phosphate, cetyl phosphate, C 6~10 Pareth-4 Phosphate, C 12~15 Pareth-2 Phosphate, C 12~15Pareth-3 phosphate, DEA-ceteareth-2 phosphate, DEA-cetyl phosphate, DEA-oleth-3 phosphate, potassium cetyl phosphate, deceth-4 phosphate, deceth-6 phosphate, and trilaureth-4 phosphate. A particular phosphate ester emulsifier according to the invention is potassium cetyl phosphate, available commercially, for example, as Amphisol® K from DSM Nutritional Products Ltd, Kaiseraugst.

[0066] Further suitable O / W emulsifiers according to the invention are PEG-30 dipolyhydroxystearate, PEG-4 dilaurate, PEG-8 dioleate, PEG-40 sorbitan peroleate, PEG-7 glyceryl cocoate, PEG-20 almond glycerides, PEG-25 hydrogenated castor oil, glyceryl stearate (and) PEG-100 stearate, PEG-7 olivate, PEG-8 oleate, PEG-8 laurate, PEG-60 almond glycerides, PEG-20 methyl glucose sesquistearate, PEG-40 stearate, PEG-100 Stearate, PEG-80 sorbitan laurate, steareth-2, steareth-12, oleth-2, ceteth-2, laureth-4, oleth-10, oleth-10 / polyoxyl 10 oleyl ether, ceteth-10, isosteareth-20, ceteareth-20, oleth-20, steareth-20, steareth-21, ceteth-20, isoceteth-20, laureth-23, steareth-100, glyceryl stearatocitrate, glyceryl stearate (self-emulsifying), stearic acid, salt of stearic acid, polyglyceryl-3-methylglycosedistearate. Further suitable emulsifiers are sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate and hydrated polyisobutene. Furthermore, one or more synthetic polymers can be used as emulsifiers. For example, PVP eicosene copolymer, acrylate / C 10~30Alkyl acrylate crosspolymer, acrylates / steareth-20 methacrylate copolymer, PEG-22 / dodecyl glycol copolymer, PEG-45 / dodecyl glycol copolymer, and mixtures thereof. Specific preferred emulsifiers for use in topical compositions according to the present invention are polyhydroxystearic acid, ceteareth-6, ceteareth-25, optionally mixed with stearyl alcohol, and mixtures thereof.

[0067] Another particularly suitable class of O / W emulsifiers are the non-ionic self-emulsifying systems derived from olive oil known as sorbitan olivate (chemical composition: sorbitan and cetearyl esters of olive oil fatty acids), for example sold under the trade names (INCI name) Cetearyl Olivate and OLIVEM 1000.

[0068] Also suitable are commercially available polymeric emulsifiers such as hydrophobically modified polyacrylic acids, such as acrylates / C10-30 alkyl acrylate crosspolymers sold under the tradenames Pemulen® TR-1 and TR-2 by Noveon.

[0069] Another class of particularly suitable emulsifiers are polyglycerol esters or diesters of fatty acids, also called polyglyceryl esters / diesters (i.e., polymers in which fatty acids are linked by esterification with polyglycerol), such as those sold by Evonik under the name Isolan GPS (INCI name, Polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate (i.e., diesters of a mixture of isostearic acid, polyhydroxystearic acid, and sebacic acid with polyglycerol-4)), or Dehymuls PGPH (INCI, Polyglyceryl-2 dipolyhydroxystearate) sold by Cognis.

[0070] Also suitable are polyethylene glycol ethers such as Brij 72 (polyoxyethylene (2) stearyl ether) or Brij 721 (polyoxyethylene (21) stearyl ether, available, for example, from Croda).

[0071] The at least one O / W or Si / W emulsifier is preferably used in an amount of 0.5 to 10 wt. %, such as in particular in the range of 0.5 to 5 wt. %, most in particular in the range of 0.5 to 4 wt. %, based on the total weight of the composition.

[0072] Suitable W / O or W / Si emulsifiers according to the invention are polyglyceryl-2-dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, cetyl dimethicone copolyol, polyglyceryl-3 diisostearate polyglycerol ester of oleic acid / isostearic acid, polyglyceryl-6 hexalicinoleate, polyglyceryl-4-oleate, polyglyceryl-4 oleate / PEG-8 propylene glycol cocoate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallowate, potassium castorate, sodium oleate, and mixtures thereof. Further suitable W / O emulsifiers are lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone and / or PEG-9 polydimethylsiloxyethyl dimethicone and / or cetyl PEG / PPG-10 / 1 dimethicone and / or PEG-12 dimethicone crosspolymer and / or PEG / PPG-18 / 18 dimethicone. The at least one W / O emulsifier is preferably used in an amount of about 0.001 to 10% by weight, more preferably 0.2 to 7% by weight, relative to the total weight of the composition.

[0073] The topical composition according to the invention further advantageously comprises at least one co-surfactant, for example, selected from the group of mono- and diglycerides and / or fatty alcohols. The co-surfactant is generally used in an amount selected from the range of 0.1 to 10% by weight, particularly from 0.5 to 7% by weight, and most particularly from 1 to 5% by weight, based on the total weight of the composition. Particularly suitable co-surfactants are selected from the list of alkyl alcohols, such as cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanette O), stearyl alcohol (Lanette 18), behenyl alcohol (Lanette 22), glyceryl stearate, glyceryl myristate (Estol 3650), hydrogenated cocoglycerin (Lipocire Na10), and mixtures thereof.

[0074] The compositions according to the invention in the form of O / W emulsions can be provided, for example, in all formulation forms of O / W emulsions, such as serums, milks or creams, which are prepared according to the usual methods. The compositions that are the subject of the invention are intended for topical application and can in particular constitute dermatological or cosmetic compositions, for example intended to protect human skin against the harmful effects of ultraviolet radiation (anti-wrinkle, anti-aging, moisturizing, sun protection, etc.).

[0075] According to an advantageous embodiment of the invention, the composition constitutes a cosmetic composition and is intended for topical application to the skin.

[0076] Finally, a subject of the present invention is a method for the cosmetic treatment of keratinous materials, in particular the skin, in which a composition as defined above is applied to said keratinous materials, in particular the skin, said method being particularly suitable for protecting the skin from the harmful effects of ultraviolet radiation, in particular sunburn and / or photoaging.

[0077] According to the present invention, the compositions according to the present invention may contain additional ingredients, such as ingredients for skin whitening, sun protection, treatment of hyperpigmentation, preventing or reducing acne, wrinkles, lines, atrophy, and / or inflammation, chelating agents and / or sequestrants, anti-cellulite and slimming (e.g., phytanic acid), stabilizing, moisturizing, and energizing, self-tanning, soothing, and agents for improving elasticity and skin barrier, and / or additional UV filter substances and carriers and / or excipients or diluents, which are conventionally used in topical compositions. Unless otherwise specified, the excipients, additives, diluents, etc. described below are suitable for topical compositions according to the present invention. The required amounts of cosmetic and dermatological adjuvants and additives can be easily determined by those skilled in the art based on the desired product. Additional ingredients can be added to the oily phase, the aqueous phase, or separately, as deemed appropriate. Additional formulations can be easily adapted by those skilled in the art.

[0078] The cosmetically active ingredients useful herein can, in some cases, provide multiple benefits or act via multiple mechanisms of action.

[0079] The topical cosmetic compositions of the present invention may also contain conventional cosmetic adjuvants and additives, such as preservatives / antioxidants, fatty substances / oils, water, organic solvents, silicones, thickeners, emollients, emulsifiers, sunscreens, antifoaming agents, moisturizers, aesthetic ingredients such as fragrances, surfactants, fillers, sequestering agents, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifying or basifying agents, dyes, colorants / coloring agents, abrasives, absorbents, essential oils, skin sensates, astringents, antifoaming agents, pigments or nanopigments, e.g., suitable for exerting a photoprotective effect by physically filtering ultraviolet light, or any other ingredient typically incorporated into cosmetic compositions. Such cosmetic ingredients commonly used in the skin care industry that are suitable for use in the compositions of the present invention are described, for example, but not limited to, in the CTFA Cosmetic Ingredient Handbook, Second Edition (1992), The Cosmetic, Toiletry and Fragrance Association, Inc.

[0080] The required amounts of cosmetic and dermatological adjuvants and additives can be readily selected by one skilled in the art based on the desired product and are exemplified, but not limited to, in the examples.

[0081] Of course, one skilled in the art will take care to select the above-mentioned optional additional compound(s) and / or their amounts such that the advantageous properties inherently associated with the combination according to the invention are not adversely affected, or not substantially adversely affected, by the envisaged addition(s).

[0082] In one advantageous embodiment of the invention, the topical composition according to the invention does not comprise (i.e. does not have) 3-(4-methylbenzylidene)-camphor, 2-hydroxy-4-methoxybenzophenone (INCI: oxybenzone), and ethylhexyl 2-cyano-3,3-diphenylacrylate (INCI: octocrylene).

[0083] In another advantageous embodiment of the invention, the topical composition according to the invention further comprises one or more of dibutyl adipate, dicaprylyl carbonate, C12-C15 alkyl benzoate, caprylyl carbonate, capric / caprylic triglyceride, and mixtures thereof.

[0084] In a further advantageous embodiment of the present invention, the topical composition of the present invention further comprises a preservative and / or preservative booster, preferably selected from the group consisting of phenoxyethanol, ethylhexylglycerin, hexylglycerin, glyceryl caprylate, caprylyl glycol, 1,2-hexanediol, propanediol, propylene glycol, p-hydroxyacetophenone, and mixtures thereof, most preferably selected from the group of p-hydroxyacetophenone and hexylglycerin and mixtures thereof. If present, the preservative or preservative booster is preferably used in an amount of 0.01 to 2 wt. %, more preferably 0.05 to 1.5 wt. %, and most preferably 0.1 to 1.0 wt. %, based on the total weight of the composition.

[0085] In another advantageous embodiment, the topical composition according to the invention is free of any parabens, benzethonium chloride, piroctone olamine, lauroylarginate, methylisothiazolinone, chlormethylisothiazolinone, bronopol, benzalkonium chloride, formaldehyde-releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin and IPBC (iodopropynyl butylcarbamate).

[0086] In a further advantageous embodiment, the topical composition of the present invention further comprises one or more of glycerin or polyhydroxystearic acid, and mixtures thereof.

[0087] In a further advantageous embodiment, the topical composition of the invention further comprises a thickening agent, preferably a gum such as xanthan gum or Caesalpina spinosa gum, or a polyacrylate such as polyacrylate crosspolymer-6 and mixtures thereof.

[0088] Topical compositions according to the present invention generally have a pH in the range of 3-10, preferably in the range of 4-8, and most preferably in the range of 4-7. The pH can be readily adjusted as desired with a suitable acid, such as citric acid, or base, such as NaOH, according to standard methods in the art.

[0089] Topical compositions according to the present invention may further comprise one or more emollients to soothe and soften the skin. By way of example, the emollient may be dicaprylyl carbonate or C 12~15 Further emollients are silicones (dimethicone, cyclomethicone), vegetable oils (grape seed, sesame seed, jojoba, etc.), butters (cocoa butter, shea butter), alcohols (stearyl alcohol, cetyl alcohol), and petrolatum derivatives (petroleum jelly, mineral oil).

[0090] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are illustrative only and are not intended to limit the scope of the invention in any way.

[0091] [Example] All sensory evaluations were carried out using the emulsions shown in Table 1, which were prepared according to standard methods in the art. The determination of sensory characteristics was then carried out following a descriptive sensory evaluation process according to the protocol outlined below. - Well-trained panelists rated the stickiness parameters on a scale of 0 to 100 compared to a reference used to calibrate this scale. -Applied to the volar surface of the forearm. - 50 microliters of each emulsion was applied at 2.5 mg / cm 2 20cm corresponding to topical application of 2 The spot was applied to an area of ​​2.5 cm (radius). After application, each emulsion was rubbed in until the product was absorbed into the skin. The parameter adhesion was evaluated immediately after rubbing in the phase. -Statistical analysis was performed via p-value calculation (ANOVA p-value). A significant difference exists when the p-value is less than 0.05.

[0092] [Table 1]

[0093] As can be seen from the above results, a significant reduction in stickiness was achieved by adding high-fructose corn syrup to a composition containing PARSOL® SLX and PARSOL® ZX.

Claims

1. 1. A topical composition comprising an isomerized sugar syrup, a polysiloxane-based UV filter, and ultrafine zinc oxide, the amount of high fructose corn syrup is 0.5 to 2% by weight, based on the total weight of the topical composition; The ultrafine zinc oxide is zinc oxide particles having an average particle size selected in the range of 50 to 200 nm as determined by laser diffraction; The polysiloxane-based UV filter has the formula Ia: 【Chemistry 1】 (In the formula, X is methyl; A is of formula IIa or IIb: 【Chemistry 2】 R means methyl; R １ and R ２ means hydrogen, methyl, methoxy or ethoxy, R １ and R ２ one of which is hydrogen and the other is methyl, methoxy, or ethoxy; R ３ means methyl or ethyl, R ４ means hydrogen or methyl, R ５ and R ６ means hydrogen, r is 5 to 150; s is 2 to 10; n is 1. A topical composition which is a compound according to

2. 2. The topical composition of claim 1, wherein the polysiloxane UV filter is polysilicone-15.

3. 3. The topical composition according to claim 1, wherein the amount of the polysiloxane UV filter is selected in the range of 0.1 to 15% by weight, based on the total weight of the composition.

4. 4. The topical composition according to claim 1, wherein the amount of the polysiloxane UV filter is selected in the range of 1 to 5% by weight, based on the total weight of the composition.

5. 5. The topical composition of any one of claims 1 to 4, wherein the ultrafine zinc oxide has an average particle size selected in the range of 75 to 150 nm, as determined by laser diffraction.

6. The topical composition of any one of claims 1 to 5, wherein the ultrafine zinc oxide is surface coated.

7. 7. The topical composition of claim 1, wherein the ultrafine zinc oxide is surface coated with dimethicone, methicone, or triethoxycaprylylsilane.

8. 8. The topical composition of claim 1, wherein the amount of the ultrafine zinc oxide is selected in the range of 0.1% to 20% by weight, based on the total weight of the composition.

9. 9. The topical composition of any one of claims 1 to 8, wherein the composition is in the form of an oil-in-water (O / W) emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O / W emulsifier.

10. 10. The topical composition of claim 9, wherein the O / W emulsifier is selected from the group consisting of ceteareth-25, and ceteareth-6 and stearyl alcohol, and mixtures thereof.

11. Use of a topical composition according to any one of claims 1 to 10 as a sunscreen.

12. 1. Use of an isomerized sugar syrup to reduce the stickiness of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide, comprising: the amount of high fructose corn syrup is 0.5 to 2% by weight, based on the total weight of the topical composition; The ultrafine zinc oxide is zinc oxide particles having an average particle size selected in the range of 50 to 200 nm as determined by laser diffraction; The polysiloxane-based UV filter has the formula Ia: 【Transformation 3】 (In the formula, X is methyl; A is of formula IIa or IIb: 【Chemistry 4】 R means methyl; R １ and R ２ means hydrogen, methyl, methoxy or ethoxy, R １ and R ２ one of which is hydrogen and the other is methyl, methoxy, or ethoxy; R ３ means methyl or ethyl, R ４ means hydrogen or methyl, R ５ and R ６ means hydrogen, r is 5 to 150; s is 2 to 10; n is 1.) Use of the compound according to

13. 1. A method for reducing stickiness and / or sandiness on the skin of a topical composition comprising a polysiloxane-based UV filter and ultrafine zinc oxide, the method comprising the step of incorporating isomerized sugar corn syrup into the topical composition prior to applying the composition to the skin, the amount of high fructose corn syrup is 0.5 to 2% by weight, based on the total weight of the topical composition; The ultrafine zinc oxide is zinc oxide particles having an average particle size selected in the range of 50 to 200 nm as determined by laser diffraction; The polysiloxane-based UV filter has the formula Ia: 【Transformation 5】 (In the formula, X is methyl; A is of formula IIa or IIb: 【Transformation 6】 R means methyl; R １ and R ２ means hydrogen, methyl, methoxy or ethoxy, R １ and R ２ one of which is hydrogen and the other is methyl, methoxy, or ethoxy; R ３ means methyl or ethyl, R ４ means hydrogen or methyl, R ５ and R ６ means hydrogen, r is 5 to 150; s is 2 to 10; n is 1.

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