Oral components

Abstract

To provide an oral composition that contains a water-soluble copper salt and has a reduced metallic taste.SOLUTION: An oral composition contains a water-soluble copper salt, as well as Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and / or Panax ginseng extract, so that a metallic taste derived from the water-soluble copper salt is reduced, and a good feeling of use is achieved.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition containing a water-soluble copper salt and having a reduced metallic taste. [Background technology]

[0002] Water-soluble copper salts such as copper gluconate are known to have a deodorizing effect and are widely used in oral compositions such as dentifrices and mouthwashes to prevent bad breath. However, oral compositions containing water-soluble copper salts have the drawback of leaving a metallic taste after use.

[0003] Therefore, various formulation technologies for suppressing the metallic taste in oral compositions containing water-soluble copper salts have been investigated. For example, Patent Document 1 describes that an oral composition containing a water-soluble copper salt, benzyl alcohol, and xylitol and / or erythritol in a specific ratio can suppress the metallic taste. Patent Document 1 also describes that an oral composition containing a water-soluble copper salt and a propylene glycol alginate in a specific ratio has an excellent long-lasting effect of suppressing bad breath and can suppress the metallic taste.

[0004] The requirements for the functionality of oral compositions are increasing year by year, and it is necessary to respond to the diversification of oral composition formulations. Therefore, there is a need to develop new formulations that can suppress the metallic taste of oral compositions containing water-soluble copper salts. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] International Publication No. 2016 / 93279 [Patent Document 2] Japanese Patent Application Laid-Open No. 2016-141661 Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide an oral composition which contains a water-soluble copper salt and has a reduced metallic taste. [Means for solving the problem]

[0007] The present inventors have conducted extensive research to solve the above problems and have found that by incorporating an angelica extract, peony extract, sage extract, and / or carrot extract in an oral composition together with a water-soluble copper compound, the metallic taste caused by water-soluble copper salts can be suppressed and an excellent feel can be imparted to the oral composition.The present invention was completed through further research based on this finding.

[0008] That is, the present invention provides the following aspects. Item 1. An oral composition comprising (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of angelica extract, peony extract, sage extract, and carrot extract. Item 2. The oral composition according to Item 1, wherein component (A) is copper gluconate. Item 3. A method for suppressing a metallic taste caused by a water-soluble copper salt in an oral composition containing the water-soluble copper salt, comprising: A method for suppressing metallic taste, comprising blending an oral composition with (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of angelica extract, peony extract, sage extract, and carrot extract. [Effects of the Invention]

[0009] According to the present invention, in an oral composition containing a water-soluble copper salt, the metallic taste caused by the water-soluble copper salt is suppressed, and therefore an excellent feeling when used can be imparted. DETAILED DESCRIPTION OF THE INVENTION

[0010] 1.Oral composition The oral composition of the present invention is characterized by containing (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, peony extract, sage extract, and carrot extract. The oral composition of the present invention will be described in detail below.

[0011] [Water-soluble copper salt] The oral composition of the present invention contains a water-soluble copper salt (sometimes referred to as component (A)). The water-soluble copper salt is a water-soluble organic acid salt or inorganic salt of copper.

[0012] The type of water-soluble copper salt used in the present invention is not particularly limited, as long as it is applicable to the oral cavity, and examples include copper gluconate, copper sulfate, copper chloride, copper citrate, copper nitrate, copper acetate, copper lactate, copper butyrate, copper formate, copper phosphate, copper malate, copper succinate, copper malonate, copper maleate, etc.

[0013] These water-soluble copper salts may be used alone or in combination of two or more. Of these water-soluble copper salts, copper gluconate is preferred.

[0014] The content of component (A) in the oral composition of the present invention may be appropriately set depending on the form of the oral composition, the type of water-soluble copper salt used, the degree of deodorizing effect to be imparted, etc., and may be, for example, 0.0001 to 5 wt %, preferably 0.0001 to 1 wt %, more preferably 0.001 to 0.1 wt % in terms of the total amount of water-soluble copper compounds.

[0015] [Angelica extract, peony extract, sage extract, and / or carrot extract] The oral composition of the present invention contains, in addition to the water-soluble copper salt, at least one plant extract (sometimes referred to as component (B)) selected from the group consisting of Angelica acutiloba extract, peony extract, sage extract, and carrot extract. In the oral composition of the present invention, these plant extracts play a role in suppressing the metallic taste caused by the water-soluble copper salt.

[0016] Dong quince, scientifically known as Angela acutiloba, is a perennial plant belonging to the genus Angelica in the family Apiaceae. Dong quince extract can be obtained by extracting the roots of Dong quince or its related plants (Umbelliferae), optionally removing the n-hexane and / or n-butanol-soluble portion. That is, in the present invention, Dong quince extract includes not only extracts of Dong quince but also extracts of plants closely related to Dong quince.

[0017] Peony, scientific name Paeonia lactiflora, is a perennial plant of the genus Paeonia in the family Paeoniaceae. Peony extract can be obtained by extracting the roots of peony or its related plants (Paeoniaceae). That is, in the present invention, peony extract includes not only extracts of peony but also extracts of plants closely related to peony.

[0018] Sage, whose scientific name is Salvia officinalis, is a perennial or evergreen shrub of the Lamiaceae family. The sage extract used in the present invention can be obtained by extracting the whole plant or leaves (preferably the leaves) of sage.

[0019] Ginseng, whose scientific name is Panax ginseng, is also known as Panax ginseng (Japanese name), and is a perennial plant belonging to the genus Panax in the family Araliaceae. Ginseng extract can be obtained by extracting the whole plant or roots (preferably the roots) of the carrot.

[0020] The extraction process for obtaining the plant extract may be a general extraction method used in the production of ordinary plant extracts. The plant raw material for the plant extract may be in its raw state, or may be subjected to pretreatment such as crushing, cutting, steaming, rolling, drying, or roasting, as necessary.

[0021] The extraction treatment can be carried out by solvent extraction treatment, supercritical extraction treatment, steam distillation treatment, etc. Among these, solvent extraction treatment is preferred.

[0022] The extraction solvent used in the solvent extraction treatment may be appropriately selected depending on the type of plant, and examples thereof include water; lower alcohols having 1 to 4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, and n-butanol; polyhydric alcohols, such as propylene glycol and 1,3-butylene glycol; and mixtures thereof. More specifically, in the case of Angelica acutiloba extract, peony extract, and carrot extract, the extraction solvent is preferably water, polyhydric alcohols, and mixtures thereof; more preferably water, 1,3-butylene glycol, and mixtures thereof; and even more preferably a mixture of water and 1,3-butylene glycol. In the case of sage extract, the extraction solvent is preferably water, lower alcohols, and mixtures thereof; more preferably water, ethanol, and mixtures thereof; and even more preferably a mixture of water and ethanol.

[0023] When a mixed solvent of water and a lower alcohol is used as the extraction solvent, the content of the lower alcohol in the mixed solvent is, for example, 10 to 99% by volume, preferably 20 to 99% by volume, more preferably 30 to 95% by volume, and even more preferably 40 to 95% by volume. When a mixed solvent of water and a polyhydric alcohol is used as the extraction solvent, the content of the polyhydric alcohol in the mixed solvent is, for example, 10 to 90% by volume, preferably 20 to 80% by volume, more preferably 30 to 70% by volume, and even more preferably 40 to 60% by volume.

[0024] Solvent extraction can be carried out by immersing or refluxing the plant material in the extraction solvent. After the extraction, solid matter is removed by solid-liquid separation to obtain a plant extract. The obtained extract can be used as an extract as is, or, if necessary, a concentrated extract or a dried extract can be obtained by removing part or all of the solvent.

[0025] In the oral composition of the present invention, component (B) may be one selected from angelica extract, peony extract, sage extract, and carrot extract and used alone, or two or more of these may be used in combination.

[0026] The content of component (B) in the oral composition of the present invention may be appropriately determined depending on the form of the oral composition, the type of plant extract used, and other factors, but may be, for example, 0.0001 to 1 wt. % in terms of the dry weight of component (B). From the viewpoint of more effectively suppressing the metallic taste caused by water-soluble copper salts, the content of component (B) in the oral composition of the present invention (in terms of dry weight) is preferably 0.001 to 0.5 wt. %, more preferably 0.01 to 0.2 wt. In the present invention, the dry weight of component (B) refers to the value obtained by converting the components derived from the plant raw materials in the plant extract into dry weight (dry solids), and if the plant extract contains solvents, excipients, etc., this refers to the value equivalent to the weight excluding these.

[0027] In the oral composition of the present invention, the ratio of component (A) to component (B) is determined depending on the respective contents of these two components, but for example, the ratio of component (B) is 0.001 to 100 parts by weight, preferably 0.1 to 50 parts by weight, and more preferably 1 to 20 parts by weight, calculated on a dry weight basis, per 1 part by weight of component (A).

[0028] [Other ingredients] The oral composition of the present invention may contain other medicinal ingredients, if necessary, in addition to the above-mentioned ingredients. Such medicinal ingredients are not particularly limited, as long as they can be incorporated into pharmaceuticals, oral care products, etc. Examples of such medicinal ingredients include bactericidal ingredients, bronchodilators, antitussives, expectorants, anti-inflammatory agents, glucosyltransferase inhibitors, plaque inhibitors, hypersensitivity inhibitors, anti-tartar agents, antipyretics, analgesics, antihistamines, disinfectants, gastric mucosa protectants, caffeines, vitamins, herbal medicines, and herbal ingredients.

[0029] The oral composition of the present invention may contain bases and additives to obtain a desired formulation. Such bases and additives are not particularly limited as long as they can be incorporated into pharmaceuticals, oral care products, etc. Examples of such bases and additives include aqueous solvents (water, lower alcohols, etc.), oily components, polyhydric alcohols, surfactants, freshening agents, preservatives, thickeners, fragrances, flavoring agents, colorants, deodorizing components (other than water-soluble copper salts), pigments, buffers, pH adjusters, etc.

[0030] [Shape / dosage form] The form of the oral composition of the present invention is not particularly limited, and may be liquid, semi-solid (gel, ointment, paste), or solid, but is preferably liquid or semi-solid.

[0031] The formulation form of the oral composition of the present invention is not limited as long as it can be applied to the oral cavity and remain there for a certain period of time, and examples thereof include oral care products such as liquid dentifrices, toothpastes, mouthwashes, oral sprays (including throat sprays), mouthwashes, mouth fresheners, oral pastes, and gum massage creams. Of these, preferred are liquid dentifrices, toothpastes, mouthwashes, and mouthwashes, and more preferred are liquid dentifrices and toothpastes.

[0032] 2. How to reduce metallic taste The method for suppressing metallic taste of the present invention is a method for suppressing the metallic taste caused by water-soluble copper salts in an oral composition containing water-soluble copper salts, and is characterized by blending (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of angelica extract, peony extract, sage extract, and carrot extract into the oral composition.

[0033] In the method for suppressing metallic taste of the present invention, the types and amounts of ingredients used, the shape and formulation of the oral composition, etc. are as shown in the section "1. Oral composition" above. [Example]

[0034] The present invention will be explained in more detail below by showing examples, but the present invention is not limited to these examples.

[0035] The plant extracts used in the following test examples and formulation examples are as follows: The content of each plant extract shown in the following Tables 1 to 3 is the content as a liquid extract. Angelica acutiloba extract : The roots of Angelica acutiloba are extracted with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol, and the dry solids are converted into a liquid extract (dry solids content is approximately 3.8 w / v%). Peony extract : A liquid extract (dry solid content approximately 4 w / v%) obtained by extracting peony root with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol. Sage extract : A liquid extract (dry solid content approximately 1 w / v%) obtained by extracting sage leaves with an aqueous solution containing approximately 90% by volume of ethanol. Carrot extract : A liquid extract (dry solid content approximately 1.3 w / v%) obtained by extracting ginseng root with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol.

[0036] Test Example 1 The oral compositions (liquid) shown in Table 1 were prepared. The metallic taste of the obtained oral compositions was evaluated by 10 trained subjects. Specifically, one drop of each oral composition was placed in the mouth using a dropper, and the metallic taste was evaluated by a questionnaire using a visual analogue scale (VAS). In the questionnaire, the left end of a 10 cm line was designated as "very strong metallic taste" and the right end as "no metallic taste." The subjects were asked to mark the position on the line that corresponded to the sensation they felt when placing each oral composition in their mouths. The distance from the left end (0 cm) of the marked position was recorded as the VAS measurement value. The average of the obtained VAS measurements was recorded as the metallic taste evaluation result.

[0037] The results are shown in Tables 1 and 2. An oral composition containing copper gluconate alone gave off a strong metallic taste (Comparative Example 1), and even when the sweetener or masking agent glycerin or sorbitol was added, the metallic taste caused by copper gluconate could not be suppressed (Comparative Examples 2 and 3). In contrast, oral compositions containing copper gluconate together with angelica extract, peony extract, sage extract, or carrot extract were able to suppress the metallic taste and provided an excellent sensation in use (Examples 1 to 8).

[0038] [Table 1]

[0039] Prescription example A toothpaste having the composition shown in Table 2 and a liquid toothpaste having the composition shown in Table 3 were prepared. Both the toothpaste and liquid toothpastes suppressed the metallic taste caused by water-soluble copper salts.

[0040] [Table 2]

[0041] [Table 3]

Claims

1. An oral composition comprising (A) a water-soluble copper salt and (B) an Angelica acutiloba extract obtained using an extraction solvent selected from the group consisting of a lower alcohol having 1 to 4 carbon atoms, a polyhydric alcohol, a mixture of water and a lower alcohol having 1 to 4 carbon atoms, and a mixture of water and a polyhydric alcohol.

2. The oral composition according to claim 1, wherein component (A) is copper gluconate.

3. A method for suppressing a metallic taste caused by a water-soluble copper salt in an oral composition containing the water-soluble copper salt, comprising: A method for suppressing a metallic taste, comprising blending (A) a water-soluble copper salt and (B) an Angelica acutiloba extract obtained using an extraction solvent selected from the group consisting of lower alcohols having 1 to 4 carbon atoms, polyhydric alcohols, mixtures of water and lower alcohols having 1 to 4 carbon atoms, and mixtures of water and polyhydric alcohols, into an oral composition.

Images