Gas partial pressure measuring device and extracorporeal circulation device

Abstract

To provide: a gas partial pressure measurement device capable of measuring a gas partial pressure in blood without using an electrode; and an extracorporeal circulation device.SOLUTION: A gas partial pressure measurement device 3 includes: a gas exchange unit 32 that exchanges gas between blood and air when the blood circulating in a blood circuit 2 is introduced and the air is supplied; a gas concentration sensor 361 that detects concentration of the gas subjected to gas exchange with the blood by the gas exchange unit 32; and a calculation unit 381 that calculates a gas partial pressure value in the blood on the basis of a gas concentration value detected by the gas concentration sensor 361.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a gas partial pressure measuring device and an extracorporeal circulation device. [Background technology]

[0002] BACKGROUND ART Conventionally, in extracorporeal circulation devices, a method of inserting electrodes into a blood circuit to measure the partial pressure of oxygen and carbon dioxide in the blood has been common (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 63-66437 Summary of the Invention [Problem to be solved by the invention]

[0004] However, since the blood circuit is connected to the human body, when measuring the partial pressure of oxygen or carbon dioxide in the blood, it is preferable that the electrodes do not come into contact with the blood, taking into consideration the effects on the human body, and it is preferable that no electrodes are used.

[0005] An object of the present invention is to provide a gas partial pressure measuring device and an extracorporeal circulation device that can measure the gas partial pressure in blood without using electrodes. [Means for solving the problem]

[0006] The present invention relates to a gas partial pressure measuring device comprising a gas exchange unit that performs gas exchange between the blood and air by introducing blood circulating through a blood circuit and supplying air thereto, a gas concentration sensor that detects the concentration of gas exchanged with the blood by the gas exchange unit, and a calculation unit that calculates the partial pressure of gas in the blood based on the gas concentration value detected by the gas concentration sensor.

[0007] The gas exchange section preferably has a plurality of porous membranes.

[0008] It is also preferable to provide an air supply unit that supplies air to the gas exchange unit.

[0009] It is also preferable to provide a gas outlet path that discharges air containing the gas exchanged in the gas exchange section toward the gas concentration sensor, and a pump that is disposed in the gas outlet path and sends air containing the gas exchanged in the gas exchange section toward the gas concentration sensor.

[0010] It is also preferable to provide a circulation path for circulating air containing gas that has been gas exchanged with blood by the gas exchange section to the gas exchange section.

[0011] It is also preferable to provide an outside air supply unit that supplies outside air to the gas exchange unit.

[0012] The present invention also relates to an extracorporeal circulation apparatus including a blood circuit, an oxygenator disposed in the blood circuit, and the gas partial pressure measuring device disposed in the blood circuit.

[0013] It is also preferable that the oxygenator and the gas partial pressure measuring device are integrated into one body. [Effects of the Invention]

[0014] According to the present invention, it is possible to provide a gas partial pressure measuring device and an extracorporeal circulation device that can measure the gas partial pressure in blood without using electrodes. [Brief explanation of the drawings]

[0015] [Figure 1] 1 is a diagram showing the configuration of an extracorporeal circulation apparatus according to a first embodiment. [Figure 2] FIG. 1 is a diagram showing a gas partial pressure measuring device according to a first embodiment. [Figure 3] FIG. 4 is a diagram showing a gas partial pressure measuring device according to a second embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0016] Hereinafter, embodiments of the present invention will be described with reference to the drawings. Fig. 1 is a diagram showing the configuration of an extracorporeal circulator 1 according to a first embodiment. The extracorporeal circulator 1 of the first embodiment is used, for example, when performing surgery on a heart H.

[0017] 1, the extracorporeal circulation device 1 includes a blood circuit 2. The blood circuit 2 includes a venous line 21, a blood reservoir 22, a blood pump 23 that pumps blood from the blood reservoir 22, an oxygenator 24, an arterial line 25, a gas partial pressure measurement line 26, and a gas partial pressure measurement device 3.

[0018] The venous line 21, the arterial line 25, and the gas partial pressure measurement line 26 are made of flexible tubes such as polyvinyl chloride.

[0019] The venous line 21 is connected to the vena cava located near the heart H, and sends blood flowing from the vena cava to the blood reservoir 22.

[0020] Blood reservoir 22 stores the blood flowing through venous line 21 and gas partial pressure measurement line 26. To blood reservoir 22, the downstream end of venous line 21 and the downstream end of gas partial pressure measurement line 26 are connected.

[0021] The blood pump 23 is disposed downstream of the blood reservoir 22 and sends blood from the blood reservoir 22 to the oxygenator 24. A well-known centrifugal pump or roller pump is used as the blood pump 23. In this embodiment, a centrifugal pump is used as the blood pump 23, and a rotor provided therein is driven to pump the blood.

[0022] The oxygenator 24 is disposed downstream of the blood pump 23 and includes hollow fibers with excellent gas permeability. The oxygenator 24 performs gas exchange, such as adding oxygen to the blood and removing carbon dioxide from the blood. An oxygen supply means (not shown), such as an oxygen tank, is connected to the oxygenator 24, and oxygen to be added to the blood is supplied from this oxygen supply means to the oxygenator 24. The oxygenator 24 is also provided with, for example, a heat exchanger for adjusting the temperature of the blood by heat exchange.

[0023] The downstream end of the arterial line 25 is connected to the aorta near the heart H, and returns the blood that has been gas-exchanged and heat-exchanged by the oxygenator 24 to the aorta near the heart H.

[0024] The gas partial pressure measurement line 26 branches off from the arterial line 25 midway, and its downstream end is connected to the blood reservoir 22. A gas partial pressure measurement device 3 is disposed midway along the gas partial pressure measurement line 26.

[0025] The gas partial pressure measuring device 3 is a device that measures the oxygen concentration or carbon dioxide concentration (gas concentration) of the blood flowing through the arterial line 25 and calculates the oxygen partial pressure or carbon dioxide partial pressure (gas partial pressure) in the blood flowing through the gas partial pressure measuring line 26.

[0026] As shown in FIG. 2, the gas partial pressure measuring device 3 comprises a blood inlet line 31 that introduces blood supplied via the gas partial pressure measurement line 26, a gas exchange section 32 (gas exchange section) arranged at the downstream end of the blood inlet line 31, a blood discharge line 33 that discharges blood discharged from the gas exchange section 32 to the gas partial pressure measurement line 26, a gas outlet line 34 (gas outlet path) that circulates air containing gas discharged from the gas exchange section 32, a pump 35 arranged midway along the gas outlet line 34, a gas storage section 36 connected to the downstream end of the gas outlet line 34, an oxygen concentration sensor 361 and a carbon dioxide concentration sensor 362 arranged inside the gas storage section 36, an air supply line 37 (air supply section) that supplies the air stored in the gas storage section 36 to the gas exchange section 32, a control section 38, and a display section 39.

[0027] In this embodiment, the gas partial pressure measuring device 3 is configured to circulate air containing gas exchanged by the gas exchange section 32 through the gas outlet line 34, gas storage section 36, and blood discharge line 33 to the gas exchange section 32, thereby supplying air to the gas exchange section 32 and performing gas exchange between blood and air. The gas outlet line 34, gas storage section 36, and air supply line 37 form a circulation path that circulates air containing gas exchanged with blood by the gas exchange section 32 to the gas exchange section 32. The gas partial pressure measuring device 3 of the first embodiment is an internal air circulation type gas partial pressure measuring device.

[0028] The gas exchange unit 32 performs gas exchange between the blood and air by introducing blood circulating through the gas partial pressure measurement line 26 via the blood inlet line 31 and supplying air via the air supply line 37. The gas exchange unit 32 includes, for example, a plurality of porous membranes. In this embodiment, the gas exchange unit 32 has, for example, hollow fibers 321 formed of a plurality of stacked porous membranes.

[0029] The gas discharge line 34 discharges air containing the gas exchanged in the gas exchange unit 32 toward the oxygen concentration sensor 361 and the carbon dioxide concentration sensor 362. The gas discharge line 34 is connected to the gas exchange unit 32 on the upstream side and to the gas storage unit 36 ​​on the downstream side. A pump 35 is disposed midway along the gas discharge line 34.

[0030] The pump 35 is disposed in the gas discharge line 34, and sends out air containing the gas exchanged in the gas exchange unit 32 toward the gas storage unit 36 ​​in which the oxygen concentration sensor 361 and the carbon dioxide concentration sensor 362 are disposed. The driving of the pump 35 is controlled by the control unit 38. The output of the pump 35 may be any output that can send the air containing the gas discharged from the gas exchange unit 32 to the gas discharge line 34 to the gas storage unit 36.

[0031] The output of pump 35 is determined, for example, based on the amount of gas exchanged, which is determined from the surface area of ​​hollow fibers 321 of gas-exchanging section 32. The output of pump 35 only needs to be an output that is capable of sending air containing gas discharged from gas-exchanging section 32 to gas discharge line 34 to gas storage section 36, and therefore is an output (1 to 1000 mL / min) that is smaller than the output (1 to 10 L / min) of an oxygen supply means such as an oxygen cylinder that sends gas to oxygenator 24 having hollow fibers similar to hollow fibers 321 of gas-exchanging section 32, and is preferably 1 to 100 mL / min, and more preferably approximately 1 to 10 mL / min.

[0032] The gas storage section stores air containing the gas that has undergone gas exchange in the gas exchange section 32. An oxygen concentration sensor 361 and a carbon dioxide concentration sensor 362 are disposed inside the gas storage section .

[0033] The oxygen concentration sensor 361 is a sensor that detects the oxygen concentration of oxygen that has been gas-exchanged with the blood by the gas exchange unit 32 and is stored in the gas storage unit 36. Concentration information on the oxygen concentration detected by the oxygen concentration sensor 361 is transmitted to the control unit 38. The carbon dioxide concentration sensor 362 is a sensor that detects the carbon dioxide concentration of carbon dioxide that has been gas-exchanged with the blood by the gas exchange unit 32 and is stored in the gas storage unit 36. Concentration information on the carbon dioxide concentration detected by the carbon dioxide concentration sensor 362 is transmitted to the control unit 38.

[0034] The air supply line 37 is connected at its upstream side to the gas storage unit 36 ​​and at its downstream side to the gas exchange unit 32. The air supply line 37 is a line that supplies air containing the gas stored in the gas storage unit 36 ​​to the gas exchange unit 32. The air supply line 37 constitutes an air supply path that supplies air to the gas exchange unit 32.

[0035] The control unit 38 controls the operation of the gas partial pressure measuring device 3. The control unit 38 is electrically connected to the pump 35, the display unit 39, the oxygen concentration sensor 361, and the carbon dioxide concentration sensor 362. The control unit 38 controls the pump 35 and the display unit 39. The control unit 38 has a calculation unit 381.

[0036] The calculation unit 381 calculates the rate of change of the oxygen concentration from the oxygen concentration in the air (approximately 20%) based on the concentration value of the oxygen concentration detected by the oxygen concentration sensor 361, and calculates the oxygen partial pressure (gas partial pressure) in the blood by referring to the atmospheric pressure information and humidity information.

[0037] In addition, the calculation unit 381 calculates the rate of change of the carbon dioxide concentration from the carbon dioxide concentration in the air (approximately 0.04%) based on the carbon dioxide concentration value detected by the carbon dioxide concentration sensor 362, and calculates the carbon dioxide partial pressure (gas partial pressure) in the blood by referring to the atmospheric pressure information and humidity information.

[0038] The display unit 39 displays various information of the gas partial pressure measuring device 3. The display on the display unit 39 is controlled by the control unit 38. The display unit 39 displays, for example, the operating status of the gas partial pressure measuring device 3, the partial pressure of oxygen and the partial pressure of carbon dioxide in the blood measured by the gas partial pressure measuring device 3, and whether the partial pressure of oxygen and the partial pressure of carbon dioxide in the blood are normal or abnormal, using a message or the like.

[0039] Next, we will explain the operation of the gas partial pressure measuring device 3 placed in the blood circuit 2 of this embodiment. The blood circuit 2 is configured so that the venous line 21 is connected to the vena cava near the heart H, and the arterial line 25 is connected to the aorta near the heart H.

[0040] In the blood circuit 2, blood removed from the heart H is stored in a blood reservoir 22. The blood stored in the blood reservoir 22 is sent to an oxygenator 24 by a blood pump 23. The blood sent to the oxygenator 24 undergoes gas exchange in which oxygen is added to the blood and carbon dioxide is removed. In addition, the temperature of the blood passing through the oxygenator 24 is adjusted. The blood is then returned to the aorta near the heart H via an arterial line 25.

[0041] In the blood circuit 2, the arterial line 25 branches into a gas partial pressure measurement line 26, and the downstream end of the gas partial pressure measurement line 26 is connected to the blood reservoir 22. A gas partial pressure measurement device 3 is disposed in the gas partial pressure measurement line 26.

[0042] The gas partial pressure measuring device 3 measures the oxygen partial pressure in the blood discharged from the oxygenator 24. In the gas partial pressure measuring device 3, the blood circulating through the gas exchange section 32 exchanges gas with air. The gas exchanged by the gas exchange section 32 is discharged by the pump 35 via the gas discharge line 34 and stored in the gas storage section 36.

[0043] The oxygen concentration of the gas contained in gas containing unit 36 ​​is detected by oxygen concentration sensor 361, and the oxygen partial pressure in the blood is calculated by calculation unit 381. The oxygen partial pressure value in the blood calculated by calculation unit 381 is displayed on display unit 39. In this way, by measuring the oxygen partial pressure in the blood discharged from oxygenator 24 in arterial line 25 downstream of oxygenator 24, if the oxygen partial pressure value is within a predetermined normal value range, it can be confirmed that oxygenator 24 is operating normally and that an appropriate amount of oxygen is being supplied to the blood by oxygenator 24.

[0044] The gas partial pressure measuring device 3 configured as above can measure the oxygen partial pressure in the blood without using electrodes, and therefore can safely measure the oxygen partial pressure in the blood discharged from the oxygenator 24.

[0045] Furthermore, a conventional technique for measuring the oxygen partial pressure in the blood to determine whether gas exchange is occurring normally in the oxygenator 24 involves supplying a high flow rate of oxygen to the oxygenator 24 and calculating the oxygen partial pressure in the blood from changes in the oxygen concentration after gas exchange with the blood based on changes in the oxygen concentration of the supplied oxygen. However, in the method of supplying oxygen to the oxygenator 24 and calculating the oxygen partial pressure in the blood from changes in the oxygen concentration after gas exchange with the blood, because oxygen is supplied to the oxygenator 24 at a high flow rate, even if the oxygen concentration after gas exchange with the blood is detected, it is difficult to accurately determine the change in the amount of oxygen transferred to the blood from the oxygen concentration of the oxygen supplied to the oxygenator 24.

[0046] Therefore, while the prior art technology is thought to have poor measurement accuracy because it measures changes in the concentration of oxygen flowing at a high flow rate to the oxygenator 24, the present invention uses a low-flow pump, making it possible to accurately capture changes in oxygen concentration. This allows for accurate calculation of the oxygen partial pressure in the blood, making it possible to accurately confirm whether gas exchange is occurring normally in the oxygenator 24.

[0047] As described above, the first embodiment provides the following advantages. The gas partial pressure measuring device 3 includes a gas exchange unit 32 that performs gas exchange between the blood and air by introducing blood circulating through the blood circuit 2 and supplying air thereto, an oxygen concentration sensor 361 that detects the oxygen concentration of oxygen exchanged with the blood by the gas exchange unit 32, and a calculation unit 381 that calculates the gas partial pressure value based on the oxygen concentration value detected by the oxygen concentration sensor 361. This allows the oxygen partial pressure in the blood to be measured safely without using electrodes, and reduces the cost required for using electrodes. Furthermore, since measurement can be performed based on changes in the oxygen concentration in the air, the oxygen partial pressure in the blood can be measured accurately.

[0048] In this embodiment, the gas-exchanging section 32 has hollow fibers 321. This allows the gas-exchanging section 32 to be configured with a simple structure.

[0049] Furthermore, this embodiment includes an air supply line 37 that supplies air to the gas-exchanging section 32. This allows air to be supplied to the gas-exchanging section 32 via the air supply line 37, enabling gas exchange between the air supplied to the gas-exchanging section 32 and the blood. Therefore, by performing gas exchange between air and blood, the oxygen partial pressure in the blood can be measured more accurately than when gas exchange is performed between oxygen and blood, as in an artificial lung.

[0050] This embodiment also includes a gas outlet line 34 that outputs air containing the gas exchanged in the gas exchange section 32 toward the oxygen concentration sensor 361, and a pump 35 that is disposed on the gas outlet line 34 and sends the air containing the gas exchanged in the gas exchange section 32 toward the oxygen concentration sensor 361. This allows the pump 35 to efficiently send the air containing the gas exchanged in the gas exchange section 32 toward the oxygen concentration sensor 361. This allows the partial pressure of oxygen in the blood to be measured stably.

[0051] Furthermore, this embodiment is provided with a circulation path (gas outlet line 34, gas storage section 36, air supply line 37) for circulating air containing gas that has been gas-exchanged with blood by the gas-exchanging section 32 to the gas-exchanging section 32. This allows the air containing gas to be circulated through the gas-exchanging section 32, thereby making it possible to detect changes in the oxygen concentration of the air containing gas over time. By circulating air containing gas that has been gas-exchanged with blood by the gas-exchanging section 32 to the gas-exchanging section 32, the partial pressure of oxygen in blood can be measured efficiently.

[0052] Next, a gas partial pressure measuring device 3A according to a second embodiment will be described with reference to Fig. 3. The second embodiment differs from the first embodiment in that, while in the first embodiment, air containing gas is circulated through the gas-exchanging section 32, in the second embodiment, outside air is introduced into the gas-exchanging section 32A without circulating air containing gas. In describing the second embodiment, the same components will be denoted by the same reference numerals, and their description will be omitted or simplified.

[0053] 3, a gas partial pressure measuring device 3A of the second embodiment includes a blood inlet line 31, a gas exchange section 32A (gas exchange section), a blood discharge line 33, a gas outlet line 34 (gas outlet path), a pump 35, a gas storage section 36A, an oxygen concentration sensor 361 and a carbon dioxide concentration sensor 362 disposed inside the gas storage section 36, a control section 38, and a display section 39. In the second embodiment, the gas partial pressure measuring device 3A does not include the air supply line 37 of the first embodiment that supplies air containing the gas stored in the gas storage section 36 to the gas exchange section 32. The gas partial pressure measuring device 3A of the second embodiment is an outside air introduction type gas partial pressure measuring device.

[0054] The gas-exchanging section 32A has an air supply section 322 (outside air supply section) that supplies outside air. The air supply section 322 supplies outside air to the gas-exchanging section 32A. This allows gas exchange between the outside air supplied from the air supply section 322 and the blood circulating in the gas-exchanging section 32A.

[0055] The gas storage unit 36A has a gas discharge unit 363 that discharges air containing gas stored in the gas storage unit 36A to the outside. This allows fresh air to be constantly supplied to the gas exchange unit 32A by discharging the air containing gas stored in the gas storage unit 36A to the outside using the gas discharge unit 363.

[0056] In the second embodiment, the output of the pump 35 is preferably smaller than the output of the pump 35 in the first embodiment (approximately 1 to 100 mL / min), and is preferably 1 to 10 mL / min.

[0057] The second embodiment has the following advantages. In the first embodiment, gas-containing air is circulated through the gas-exchanging section 32, and the gas circulated through the gas-exchanging section 32 may come into contact with blood, increasing the humidity of the gas. In contrast, the second embodiment, unlike the first embodiment, does not circulate gas-containing air through the gas-exchanging section 32A, and instead supplies outside air to the gas-exchanging section 32A as air, thereby suppressing an increase in the humidity of the gas. Therefore, the effect of an increase in the humidity of the gas is small, and the oxygen partial pressure in the blood can be measured with high accuracy.

[0058] Although a preferred embodiment of the gas partial pressure measuring device 3, 3A of the present invention has been described above, the present invention is not limited to the above-described embodiment.

[0059] For example, in the above embodiment, the gas partial pressure measuring device 3 is provided on the gas partial pressure measurement line 26 branched off from the arterial line 25, and the blood measured in the gas partial pressure measurement line 26 is returned to the arterial line 25 via the blood reservoir 22, but this is not limiting. The gas partial pressure measuring device 3 may be provided on the arterial line 25 without providing the gas partial pressure measurement line 26 branched off from the arterial line 25.

[0060] Furthermore, in the above embodiment, the gas partial pressure measuring device 3 is disposed only on the gas partial pressure measurement line 26 on the arterial line 25 side, but this is not limiting. The gas partial pressure measuring device 3 may be disposed only on the venous line 21 side, or may be disposed on both the arterial line 25 side and the venous line 21 side. When the gas partial pressure measuring device 3 is disposed on the venous line 21 side downstream of the heart H, the carbon dioxide concentration is detected by the carbon dioxide concentration sensor 362, and the carbon dioxide partial pressure in the blood is calculated from the carbon dioxide concentration, thereby measuring the carbon dioxide partial pressure in the blood. In this case, by measuring the carbon dioxide partial pressure on the venous line 21 side downstream of the heart H, the carbon dioxide partial pressure in the blood discharged from the heart H can be measured, and therefore the patient's metabolism can be confirmed.

[0061] The gas partial pressure measuring device 3 may be provided directly in the venous line 21 or in a branch circuit branching off from the venous line 21. The gas partial pressure measuring device 3 may be provided directly in the arterial line 25 or in a branch circuit branching off from the arterial line 25.

[0062] In the above embodiment, the gas-exchanging section 32 is configured by hollow fibers 321 composed of a plurality of porous membranes, but this is not limiting. For example, the gas-exchanging section may be configured by a silicon membrane. Furthermore, the gas-exchanging section may be one that does not allow blood to pass through, and may be a homogeneous membrane that allows gas exchange, an asymmetric membrane such as polymethylpentene, or a composite membrane that combines these.

[0063] Furthermore, in the above embodiment, the gas partial pressure measuring device 3 is configured as a separate entity from the oxygenator 24, but the gas partial pressure measuring device 3 and the oxygenator 24 may be configured as an integrated device. For example, the gas partial pressure measuring device 3 may be provided on either or both of the inlet and outlet sides of the oxygenator 24, and the gas partial pressure measuring device 3 and the oxygenator 24 may be integrated. The inlet side of the oxygenator 24 can measure the carbon dioxide partial pressure in the blood on the venous line 21 side, and the outlet side of the oxygenator 24 can measure the oxygen partial pressure in the blood on the arterial line 25 side. This allows the oxygenator 24 and the gas partial pressure measuring device to be integrated and used (manufactured, sold, and utilized) as a single device.

[0064] The gas partial pressure measuring device 3 may also be configured as an integrated unit with the blood reservoir 22. For example, the gas partial pressure measuring device 3 may be incorporated into the internal mechanism of the blood reservoir 22, or the gas partial pressure measuring device 3 may be installed at the inlet port or outlet port of the blood reservoir 22. The gas partial pressure measuring device 3 may also be integrated with the blood pump 23. For example, the gas partial pressure measuring device 3 may be incorporated into the internal mechanism of the blood pump 23, or the gas partial pressure measuring device 3 may be installed at the inlet port or outlet port of the blood pump 23. [Explanation of symbols]

[0065] 1 Extracorporeal circulation device 2 Blood circuit 3. 3A Gas Partial Pressure Measuring Device 24 Artificial lung 32 Gas exchange section (gas exchange section) 34 Gas outlet line (gas outlet path) 35 Pump 37 Air supply line (air supply section) 321 Hollow fibers (multiple porous membranes) 322 Air supply section (outside air supply section) 361 Oxygen concentration sensor (gas concentration sensor) 362 Carbon dioxide concentration sensor (gas concentration sensor) 381 Calculation Unit

Claims

1. a gas exchange section into which blood circulating through the blood circuit is introduced and air is supplied, thereby performing gas exchange between the blood and air; a gas concentration sensor that detects the concentration of gas exchanged with the blood by the gas exchange unit; a calculation unit that calculates a gas partial pressure value in blood based on the gas concentration value detected by the gas concentration sensor; a gas outlet path that leads air containing the gas exchanged in the gas exchange unit toward the gas concentration sensor; a pump disposed in the gas outlet path for sending air containing the gas exchanged in the gas exchange section toward the gas concentration sensor.

2. The gas partial pressure measuring device according to claim 1 , wherein the gas exchange section has a plurality of porous membranes.

3. 3. The gas partial pressure measuring device according to claim 1, further comprising an air supply unit that supplies air to the gas exchange unit.

4. 4. The gas partial pressure measuring device according to claim 1, further comprising a circulation path for circulating air containing gas that has been gas-exchanged with blood by said gas exchange unit to said gas exchange unit.

5. 4. The gas partial pressure measuring device according to claim 1, further comprising an outside air supply unit that supplies outside air to the gas exchange unit.

6. The blood circuit, an oxygenator disposed in the blood circuit; An extracorporeal circulation system comprising: a gas partial pressure measuring device according to any one of claims 1 to 5, which is disposed in the blood circuit.

7. 7. The extracorporeal circulation apparatus according to claim 6, wherein the oxygenator and the gas partial pressure measuring device are integrally configured.

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