Lysophosphatidic acid salts

Abstract

To provide a new lysophosphatidate having reduced stimulation compared to the conventional lysophosphatidate, and a cosmetic or topical skin preparation comprising the lysophosphatidate.SOLUTION: A salt of lysophosphatidic acid and a polyvalent metal selected from zinc, aluminum, calcium, barium, magnesium and iron is used. The inventive lysophosphatidate has low stimulation and also has various bioactive actions, so that it is suitable for cosmetic or topical skin preparations.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a lysophosphatidic acid salt and a cosmetic or external skin preparation containing the lysophosphatidic acid salt. [Background technology]

[0002] Phospholipids are a general term for compounds with a structure consisting of a glycerol backbone with fatty acids ester-linked at the sn-1 and sn-2 positions and a polar group containing phosphate at the sn-3 position. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), and phosphatidic acid (PA) are known depending on the polar group structure. Lysophospholipids are compounds formed by hydrolysis of one of the two fatty acids bound to a phospholipid. Lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), lysophosphatidylserine (LPS), lysophosphatidylinositol (LPI), and lysophosphatidic acid (LPA) are known. In recent years, extensive research has been conducted on these various phospholipids and lysophospholipids, focusing on their individual functions. Among these, lysophosphatidic acid has also been the subject of various studies, and in cosmetics research it has been reported to have physiologically active effects such as promoting collagen production (Patent Document 1), promoting aquaporin gene expression (Patent Document 2), promoting ceramide production, and promoting tight junction formation (Non-Patent Document 1). However, the use of lysophosphatidic acid in the cosmetics field has not progressed sufficiently. Furthermore, because lysophosphatidic acid exhibits acidic properties, it is generally used as a salt. However, monovalent metal salts such as sodium salts have traditionally been used, and polyvalent metal salts of lysophosphatidic acid have not been known. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2009 / 028220 [Patent Document 2] Japanese Patent Application Laid-Open No. 2011-063515 [Non-patent literature]

[0004] [Non-Patent Document 1] FRAGRANCE JOURNAL May 2009 issue p.31~34 Summary of the Invention [Problem to be solved by the invention]

[0005] The present inventors have conducted extensive research to promote the use of lysophosphatidic acid in the field of cosmetics and have found that conventional lysophosphatidic acid salts have a drawback in that they are highly irritating. Therefore, an object of the present invention is to provide a new lysophosphatidic acid salt that is less irritating than conventional lysophosphatidic acid salts, and to provide a cosmetic or topical skin preparation containing the lysophosphatidic acid salt. [Means for solving the problem]

[0006] As a result of extensive research to solve the above-mentioned problems, the inventors discovered that a salt of lysophosphatidic acid with a polyvalent metal selected from zinc, aluminum, calcium, barium, magnesium, and iron solves the above-mentioned problems, and thus completed the present invention. [Effects of the Invention]

[0007] The lysophosphatidate of the present invention is less irritating than conventional lysophosphatidates and has various physiologically active actions, and therefore can be preferably used in cosmetics or external skin preparations. DETAILED DESCRIPTION OF THE INVENTION

[0008] The present invention relates to a salt of lysophosphatidic acid with a polyvalent metal selected from zinc, aluminum, calcium, barium, magnesium, and iron. The lysophosphatidic acid in the present invention is a compound represented by the following general formula (1) or (2): [ka] (In the formula, R1 represents a saturated or unsaturated aliphatic acyl group having 14 to 24 carbon atoms.) [ka] (wherein R2 represents a saturated or unsaturated aliphatic acyl group having 14 to 24 carbon atoms).

[0009] Specific examples of the saturated or unsaturated aliphatic acyl group having 14 to 24 carbon atoms for R1 in general formula (1) or R2 in general formula (2) include residues derived from saturated fatty acids such as myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, and lignoceric acid; and unsaturated fatty acids such as myristoleic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, erucic acid, and docosahexaenoic acid, and are preferably residues derived from palmitic acid, stearic acid, oleic acid, linoleic acid, or linolenic acid.

[0010] The lysophosphatidic acid of the general formula (1) or (2) used in the lysophosphatidic acid salt of the present invention is not particularly limited in its production method, and can be produced by a commonly known method. Specifically, it can be produced by reacting phospholipase A1 or phospholipase A2 with phosphatidic acid in water or a mixture of water and an organic solvent.

[0011] When phosphatidic acid is reacted with phospholipase A2, lysophosphatidic acid of general formula (1) is produced as the main reaction product due to the specificity of the enzyme, but lysophosphatidic acid of general formula (2) is also produced in part. When phospholipase A1 is reacted with phosphatidic acid, lysophosphatidic acid of general formula (2) is produced as the main reaction product due to the specificity of the enzyme, but lysophosphatidic acid of general formula (1) is also produced in part. Furthermore, lysophosphatidic acid of general formula (2) is easily converted to lysophosphatidic acid of general formula (1) over time by rearrangement of the acyl group. In the present invention, lysophosphatidic acid of general formula (1) or lysophosphatidic acid of general formula (2) can be used alone, but as described above, according to general production methods, lysophosphatidic acid of general formula (1) and lysophosphatidic acid of general formula (2) are obtained as a mixture, and therefore, it is preferable to use such lysophosphatidic acid in the present invention.

[0012] The phosphatidic acid used in the production of lysophosphatidic acid used in the present invention may be one synthesized from α-glycerophosphate and a fatty acid, or one produced by reacting phosphatidylcholine with phospholipase D in water or a mixture of water and an organic solvent. The phosphatidylcholine used in the production of phosphatidic acid may be one synthesized from α-glycerophosphatidylcholine and a fatty acid, or a phosphatidylcholine-containing lecithin obtained from soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, barley, egg yolk, etc., or a hydrogenated product thereof.

[0013] From the viewpoints of economy and consumer preference, the lysophosphatidic acid used in the present invention is preferably lysophosphatidic acid obtained by treating phosphatidylcholine-containing lecithin or a hydrogenated product thereof with phospholipase D, followed by the treatment of the resulting phosphatidic acid with phospholipase A1 or phospholipase A2. Depending on the type of lecithin used as a raw material, lysophosphatidic acid obtained by such a method may contain, in addition to lysophosphatidic acid, lysophospholipids such as lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine, and lysophosphatidylinositol, and may further contain non-lysophospholipids such as phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol, depending on the degree of purification. As the lysophosphatidic acid used in the present invention, those containing various components derived from lecithin as described above in addition to lysophosphatidic acid can also be preferably used.

[0014] The lysophosphatidic acid salt of the present invention is a salt of lysophosphatidic acid and a polyvalent metal obtained by the above-mentioned method, and the polyvalent metal is selected from zinc, aluminum, calcium, barium, magnesium, and iron, and more preferably zinc or aluminum.

[0015] The method for producing the lysophosphatidic acid salt of the present invention is not particularly limited, and it can be produced by a known method.Specifically, it can be produced by neutralizing or ion-exchanging the lysophosphatidic acid salt obtained by the above-mentioned method or its salt with potassium, sodium, ammonium, triethylamine, monoethanolamine, diethanolamine, triethanolamine, lysine, arginine, etc. with a hydroxide, oxide or chloride of a polyvalent metal.Specific examples of the hydroxide, oxide or chloride of a polyvalent metal that can be used include zinc hydroxide, zinc oxide, zinc chloride, aluminum hydroxide, aluminum oxide, aluminum chloride, calcium hydroxide, calcium oxide, calcium chloride, barium hydroxide, barium oxide, barium chloride, magnesium hydroxide, magnesium oxide, magnesium chloride, iron hydroxide, iron oxide, iron chloride, etc.

[0016] The lysophosphatidic acid salt of the present invention may be used as it is, but from the viewpoint of ease of handling and improving solubility and dispersibility in water or other media, it can be used by dissolving or dispersing it in water or a polyhydric alcohol in advance. Specific examples of polyhydric alcohols include dihydric alcohols such as ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol; and trihydric alcohols such as glycerin, trimethylolpropane, and 1,2,6-hexanetriol. Examples of suitable polyols include alcohols; sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, and mannitol; glyceryl ethers such as ethylglycerin, butylglycerin, hexylglycerin, and ethylhexylglycerin; and polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used alone or in combination of two or more. Of these, glycerin is most preferred from the viewpoint of solubility, and it is desirable that the polyhydric alcohol contain 50% by mass or more, preferably 60% by mass or more, and more preferably 70% by mass or more of glycerin.

[0017] The lysophosphatidic acid salt of the present invention is low in irritation and has various physiologically active effects, and therefore can be preferably used in cosmetics or topical skin preparations. The amount of the lysophosphatidic acid salt of the present invention to be incorporated into cosmetics or topical skin preparations is not particularly limited, and is generally 0.005 to 20% by weight, preferably 0.01 to 10% by weight.

[0018] The cosmetic or topical skin preparation of the present invention may contain, as needed, water and additives typically incorporated into cosmetics, such as oily bases, moisturizers, texture improvers, surfactants, polymers, thickeners, gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant, animal, or microbial extracts, UV absorbers, antibacterial agents, preservatives, chelating agents, pH adjusters, acids, alkalis, solvents, propellants, antipruritics, exfoliants and dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory and anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle and anti-aging agents, irritation soothing agents, cooling agents, warming agents, powders, dyes, colorants, dyes, pigments, fragrances, and the like, to an extent that does not impair the effects of the present invention.

[0019] Examples of oily bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, Higher fatty acids such as undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts, and other metal soaps, as well as nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin Hydrocarbons such as α-olefin oligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, and olive oil Vegetable oils and fats such as castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, and hydrogenated jojoba oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil;Lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, acetated lanolin alcohol, and cetyl lanolyl acetate ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin. Phospholipids such as soybean phospholipid, phosphatidic acid, cyclic lysophosphatidic acid or its salt, lysolecithin, etc.; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, etc.; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid, etc.; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Acyl sarcosine alkyl esters such as cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), and N-lauroyl sarcosinate isopropyl Sterol esters such as ester, cholesteryl 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, Monoalcohol carboxylic acid esters such as ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, and diisostearyl malate;Glyceryl Trioctanoate, Glyceryl Trioleate, Glyceryl Triisostearate, Glyceryl Diisostearate, Caprylic / Capric Triglyceride, Caprylic / Capric / Myristic / Stearic Triglyceride, Hydrogenated Rosin Triglyceride (Hydrogenated Ester Gum), Rosin Triglyceride (Ester Gum), Glyceryl Behenate Eicosandioate, Trimethylolpropane Trioctanoate, Trimethylolpropane Triisostearate, Neopentyl Glycol Dioctanoate, Dicaprylate Neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, pentaerythrityl hydrogenated rosin, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearate / stearic acid / rosin acid, diglyceryl diisostearate, polyglyceryl tetraisostearate Polyol fatty acid esters such as ethylene glycol distearate, 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucate / isostearate / ricinoleate), diglyceryl oligoester of hexyldecanoate / sebacic acid, glycol distearate, alkyl ethers such as dicaprylyl ether, diisopropyl dimer dilinoleate, dimer Derivatives of dimer acid or dimer diol such as diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, phytosteryl / behenyl dimer dilinoleate, phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, hydrogenated castor oil dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethyl aminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone Preferred examples of silicones include corn gum, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane-oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyethers.

[0020] Moisturizing agents and feel improvers include polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymer; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid / tetradecanedioic acid), polyglyceryl-10 tetradecanedioate, and bisethoxydiglycol cyclohexanedicarboxylate; and sugar alkyl esters such as sorbitol, xylitol, erythritol, mannitol, and maltitol. Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycol Sugars and their derivatives, such as cogen, ethyl glucoside, and glucosyl ethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans, such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharides; organic acids, such as citric acid, tartaric acid, and lactic acid, and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.Amino acids and their salts, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine; collagen, fish collagen, atelocollagen, gelatin, elastin, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, keratin hydrolyzed peptides, hydrolyzed keratin, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy proteolytic peptides, small Protein peptides and their derivatives such as barley proteolysis peptides, hydrolyzed wheat protein, casein hydrolysis peptides, and acylated peptides; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture liquid, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, air Preferred examples of the active ingredient include animal and plant extracts such as rastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Rosa robur extract, yarrow extract, eucalyptus extract, and melilot extract, and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and glycoceramide-containing extracts;

[0021] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants, etc. The HLB of the surfactant is not particularly limited, and surfactants ranging from a low of about 1 to a high of about 20 can be used, and it is also preferable to combine surfactants with low and high HLB. Preferred examples of surfactants include anionic surfactants such as fatty acid salts (e.g., potassium laurate, potassium myristate, etc.); alkyl sulfate ester salts (e.g., sodium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, etc.); polyoxyethylene alkyl sulfates (e.g., sodium laureth sulfate, triethanolamine laureth sulfate, etc.); acyl N-methylamino acid salts (e.g., sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, sodium lauroyl methyl alanine glutamate); sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauro ... Acyl amino acid salts such as sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl aspartic acid ditriethanolamine, cocoyl alanine triethanolamine, and sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactylate salts; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkyl benzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate;Alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecylbenzene sulfonate; alkyl naphthalene sulfonates; alkane sulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate ester salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethphosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, and cyclic lysophosphatidic acid or their salts; silicones such as carboxylic acid-modified silicones, phosphate-modified silicones, and sulfate-modified silicones. glycerol-based anionic surfactants, etc.; nonionic surfactants include laureths (polyoxyethylene lauryl ethers), ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers), as well as polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; esters; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene-polyoxypropylene alkyl ethers such as polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, and polyoxyethylene-polyoxypropylene glycerin ether; polyoxyethylene-polyoxypropylene glycol; polyoxyethylene-polyoxypropylene diglyceryl; ) Glycerin polyoxypropylene glycol; glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin mono-cottonseed oil fatty acid, glycerin mono-erucate, glycerin sesquioleate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.; polyglyceryl-2, 3, 4, 5, 6, and 8 stearate , 10, Polyglyceryl-6 distearate, 10, Polyglyceryl-2 tristearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, Polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate, 3, Nos. 4, 5, 6, 8, and 10, polyglycerin fatty acid esters such as polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, and polyglyceryl-10 decaoleate; ethylene glycol mono-fatty acid esters such as ethylene glycol monostearate; propylene glycol mono-fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ethers;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; partial esters of sugar derivatives such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides Glycolipids such as mannosylerythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipids;Polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA). alkyl dimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, and cetrimonium chloride. Alkyltrimethylammonium chlorides such as lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and their salts such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl ether amines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty acid amide quaternary ammonium salts such as ethyl sulfate of long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate of lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine ammonium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives;Silicone-based cationic surfactants such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as alkyl dimethyl taurine; sulfate-type betaines such as alkyl dimethyl amino ethanol sulfate esters; phosphate-type betaines such as alkyl dimethyl amino ethanol phosphate esters; tine; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; and among polymer surfactants, preferred examples include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants.

[0022] Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its salts such as sodium salt, alginic acid and its salts such as sodium salt, mannan; starch from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan Agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and its sodium salts, methylhydroxypropyl cellulose, carboxylated cellulose nanofiber, carboxymethyl cellulose nanofiber, phosphate esterified cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfate Cellulose and its derivatives such as acid cellulose, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride starch and aluminum octenylsuccinate corn starch; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer and (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP;Partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate; carboxyvinyl polymers; polyacrylic acid and its salts such as sodium salt; acrylic acid-methacrylic acid ester copolymer; acrylic acid-alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10; diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-7; acrylic acid-diallyldimethylammonium chloride copolymer such as polyquaternium-22; acrylic acid-diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-39; acrylic acid-cationized methacrylic acid ester copolymer; acrylic acid-cationized methacrylic acid amide copolymer; acrylic acid such as polyquaternium-47 Acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymer, methacrylic acid choline ester polymer; cationic oligosaccharides, cationic dextran, guar hydroxypropyltrimonium chloride, and other cationic polysaccharides; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and their copolymers with butyl methacrylate copolymers; acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, synthetic latex, and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; various fluorine-containing polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate;Preferred examples include anhydrous silicic acid, fumed silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters;

[0023] Preferred antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid Preferred examples include ascorbic acid derivatives such as acid sulfate and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, quercetin, and apple polyphenols; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloid.

[0024] Examples of whitening agents include hydroquinone glycosides and esters thereof, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters, such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid esters, such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid. ascorbic acid glucosides and their fatty acid esters, such as ascorbic acid 2-glucoside; ascorbic acid derivatives, such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives, such as tranexamic acid, cetyl tranexamate, and tranexamic acid amide; licorice extract-related substances, such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts, such as kojic acid, ellagic acid, ferulic acid and derivatives thereof, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract, are preferred.

[0025] Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and choline; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; and vitamin B such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred examples include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate; tocotrienols; and various other vitamin derivatives.

[0026] Plant, animal and microbial extracts include iris extract, angelica extract, dolabrata extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althaea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica tree extract, echinacea leaf extract, emmeiso extract, scutellaria root extract, phellodendron bark extract, coptis japonica extract, barley extract, ginseng extract, St. John's wort extract, and nettle root. Sow extract, Ononis extract, Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oak extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, Pueraria root extract, chamomilla extract, oil-soluble chamomilla extract, carrot extract, artemisia capillaris extract, oat extract, kalk extract, licorice extract, oil-soluble licorice extract, kiwi extract, ash extract, wood ear extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guava extract, lily of the valley extract, gardenia extract, kumazasa extract, Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, Chinese radish extract, Bupleurum Root extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, Chinese holly Kisu, Zanthoxylum extract, Shiitake mushroom extract, Rehmannia root extract, Lithospermum root extract, Perilla extract, Tilia extract, Meadowsweet extract, Jatoba extract, Peony extract, Angelica root extract, Calamus root extract, Birch extract, White wood ear extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Ivy extract, Hawthorn extract, Elderberry extract, Yarrow extract, Peppermint extract, Sage extract, Mallow extract, Cnidium extract, Swertia japonica extract, Sophora japonica extract, Rhubarb extract,Soybean extract, Chinese laurel extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, jasmine extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, poria cocos extract, butcher's broom extract, grape extract, grape seed extract Preferred examples of extracts include kiss, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0027] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, Cinnamic acid-based UV absorbers such as ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl p-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate (cinoxate), cyclohexyl p-methoxycinnamate, ethyl α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl di-paramethoxycinnamate, ferulic acid and its derivatives;Benzophenone-based UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy 2-(2'-hydroxy-5'-methylphenylbenzotriazole; Dibenzalazine; Dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; Dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; Octyltriazone; Urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole Preferred examples thereof include hydantoin derivatives such as 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives;

[0028] Antibacterial and antiseptic agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, and benzalkonium chloride. Preferred examples of the antibacterial agent include methyl methyl ether, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions. However, when used as an antibacterial agent or preservative for the purpose of preservation, from the viewpoint of safety of cosmetics or topical skin preparations, it is more preferred to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether.

[0029] Preferred examples of the chelating agent include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0030] Preferred examples of the pH adjuster, acid, or alkali include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0031] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and diethylene glycol diethyl ether. Preferred examples of the propellant include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

[0032] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance P inhibitors, etc. Examples of keratin exfoliating / dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, glycolic acid, etc. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, etc. Examples of cooling agents include menthol and methyl salicylate, etc. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, caffeine, etc. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, etc. Examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium, etc.

[0033] Preferred examples of the anti-inflammatory agent include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred examples of hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E, and derivatives thereof such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid, and derivatives thereof such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and their glycosides, and minoxidil. Preferred examples of hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0034] Anti-wrinkle and anti-aging agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid 2-glucoside; and ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate. Vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, panthenol, soybean saponin, revelastol, isoflavone, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolysate, adenosine 5'-monophosphate, phosphatidylinositol, trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetic acid Na, tranexamic acid, and derivatives thereof are preferred.

[0035] Preferred examples of the irritation alleviator include mannosylerythritol lipid, dimer dilinoleic acid diethylene glycol oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, polypropylene glycol, etc. Preferred examples of the cooling agent include menthol, camphor, menthyl lactate, monomenthyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, peppermint oil, and derivatives thereof. Preferred examples of the warming agent include vanillin and its derivatives, nonanoic acid vanillylamide, shogaol, gingerol, capsicum tincture, capsicum extract, nicotinic acid derivatives such as benzyl nicotinate, methyl nicotinate, phenyl nicotinate, and tocopherol nicotinate, capsaicin, watercress extract, Japanese pepper extract, ginger extract, and canthari extract.

[0036] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide particles, zinc oxide, fine and ultrafine zinc oxide particles, alumina, silica, fumed silica (ultrafine silicic anhydride particles), titanium mica Preferred examples include inorganic powders of various sizes and shapes, such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing phlogopite, fine particle composite powders, gold, and aluminum, and inorganic powders obtained by treating these with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, and Teflon (registered trademark) powder, as well as surface-treated powders and organic-inorganic composite powders.Preferred examples of inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as mono-, di-, and tri-Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0037] Colorants, dyes, and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green 201, Green 202, Green 204, Green No. 205, Green No. 3, Green 401, and Green 402 No., Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 40 No. 4, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange 20 Legal dyes such as No. 5, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407, and Yellow 5; Acid Other acid dyes such as Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide;Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, carthamine, and quercetin. Preferred examples include natural pigments and dyes such as naphthoquinones (e.g., cinnamon, crocin, chlorophyll, curcumin, cochineal, and shikonin), bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers (e.g., p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof); autoxidation dyes (e.g., indoline); and dihydroxyacetone.

[0038] Fragrance: acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolids, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedryl acetate, terpineol acetate, pt-butylcyclohexyl acetate Al, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, tripluran, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, Alpha-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzene Preferred examples of the fragrance include synthetic and natural fragrances such as maltodextrin, borneol, myrrhizoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

[0039] Preferred examples of water include tap water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

[0040] In addition to these, it is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, ratios, and amounts, such as ingredients listed in the Cosmetic Ingredient Standards, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Ingredient Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Official Standards, and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) that fall into the International Patent Classification IPC classifications A61K7 and A61K8.

[0041] The types of the cosmetic of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, body cosmetics, etc. The cosmetic of the present invention can be produced according to a conventional method.

[0042] To explain the types of cosmetics of the present invention in more detail, preferred examples of hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, and rinse-in-one shampoo; hair care agents such as rinse, conditioner, treatment, hair pack, leave-on treatment, hair mist, and hair oil; hair styling products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and tic; hair dyes such as color lotions, hair color treatments, hair manicures, and oxidation hair dyes; hair tonics, hair liquids, hair blow dryers, split end coats, permanent wave agents, straight perm agents, hair bleach, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, and hair growth agents.

[0043] Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, and liposome lotion, emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion, emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, and keratin cream. Preferred examples include skin care cosmetics such as creams such as softening cream, gels such as moisturizing gels, whitening gels and all-in-one gels, and serums such as moisturizing essences, whitening essences, moisturizing serums and whitening serums; sunscreen cosmetics such as sun protectants, sun protectors, UV care milks and sunscreens; packs and masks such as peel-off packs, powder packs, washing packs, oil packs and cleansing masks; cleansing cosmetics such as cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels and cleansing oils; and facial cleansers such as paste facial cleansers, gel facial cleansers, foam facial cleansers, facial cleansing powders, cosmetic soaps, transparent soaps, medicated soaps, liquid soaps and shaving soaps.

[0044] Preferred examples of makeup cosmetics include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eye shadow, eyebrow pencil, nail enamel, enamel remover, and nail treatment.

[0045] Preferred examples of the aromatic cosmetics include perfumes, perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, solid perfumes, aromatic powders, perfumed soaps, body lotions, and bath oils.

[0046] Preferred examples of body cosmetics include body cleansers such as body shampoos, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays and deodorant sticks, bleaches, depilatories, bath additives, and insect repellents such as insect repellent sprays.

[0047] Preferred types of the external skin preparation of the present invention include ointments, lotions, creams or gels for external skin applications, patches, liniments, liquid applications, etc. They can also be used as oral cosmetics such as toothpastes and mouthwashes.

[0048] Preferred dosage forms of the cosmetic or topical skin preparation of the present invention include emulsion-type cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

[0049] The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples in any way.

[0050] Synthesis Example 1: Synthesis of sodium lysophosphatidic acid A 200 mL reaction vessel equipped with a stirrer, thermometer, gas inlet, and condenser was charged with 21 g of soybean lecithin (SLP-PC70, Tsuji Oil Mills), 23.8 g of n-heptane, and 31.5 g of ethyl acetate, and stirred to dissolve at 40°C. Next, 0.7 g of phospholipase D (Meito Sangyo Co., Ltd.), 36.4 g of 1.0 M sodium acetate buffer (pH 6.5), and 0.21 g of calcium chloride were added and stirred at 40°C for 20 hours. After the reaction, 16.6 g of ethanol was added and stirred for 0.5 hours. 22.5 g of 10 wt% aqueous sodium chloride solution was then added and stirred, then allowed to stand and allowed to separate. 280 g of acetone was added to the resulting upper layer, and the precipitated solid was filtered and dried to obtain a sodium phosphatidate-containing product as a yellow viscous solid. A 200 mL reaction vessel equipped with a stirrer, thermometer, gas inlet tube, and condenser was charged with 14.0 g of the yellow viscous solid obtained above, 34.0 g of n-heptane, and 22.5 g of ethyl acetate, and stirred and dissolved at 40 °C. Next, 0.21 g of phospholipase A2 (Nagase 10P / R, Nagase Chemtec), 7.0 g of 1.0 M sodium acetate buffer (pH 6.5), and 0.14 g of calcium chloride were added and stirred at 40 °C for 20 hours. After the reaction, 36.4 g of ethanol was added and stirred for 0.5 hours, followed by 25.9 g of 10 wt% aqueous sodium chloride solution, stirring, and then allowed to stand for separation. 415 g of acetone was added to the resulting lower layer, and the precipitated solid was filtered and dried to obtain a sodium lysophosphatidate-containing product as a yellow solid (yield 45%). The lysophosphatidic acid content was 25.8% by mass. The fatty acid composition was palmitic acid 30%, stearic acid 7%, oleic acid 13%, linoleic acid 42%, linolenic acid 3%, and other 5%.

[0051] Synthesis Example 2: Synthesis of sodium lysophosphatidic acid Synthesis was performed in the same manner as in Synthesis Example 1, except that phospholipase A2 in Synthesis Example 1 was replaced with phospholipase A1 (manufactured by Mitsubishi Food Chemical Co., Ltd.), and a sodium lysophosphatidate-containing product was obtained as a yellow solid (yield 48%). The lysophosphatidic acid content was 26.3% by mass. The fatty acid composition was 11% palmitic acid, 3% stearic acid, 20% oleic acid, 61% linoleic acid, 4% linolenic acid, and 1% others.

[0052] Example 1 Synthesis of aluminum lysophosphatidic acid 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 1, 7.375 g of glycerin, and 0.125 g of aluminum hydroxide were mixed and stirred at 70° C. for 3 hours to obtain aluminum lysophosphatidate as a glycerin solution.

[0053] Example 2 Synthesis of zinc lysophosphatidic acid 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 1, 7.375 g of glycerin, and 0.125 g of zinc oxide were mixed and stirred at 70° C. for 3 hours to obtain zinc lysophosphatidate as a glycerin solution.

[0054] Example 3 Synthesis of aluminum lysophosphatidic acid 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 2, 7.375 g of glycerin, and 0.125 g of aluminum hydroxide were mixed and stirred at 70° C. for 3 hours to obtain aluminum lysophosphatidate as a glycerin solution.

[0055] Example 4 Synthesis of zinc lysophosphatidate 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 2, 7.375 g of glycerin, and 0.125 g of zinc oxide were mixed and stirred at 70° C. for 3 hours to obtain zinc lysophosphatidate as a glycerin solution.

[0056] Comparative Example 1 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 1 and 7.5 g of glycerin were mixed and stirred at 70° C. for 3 hours to obtain a glycerin solution of sodium lysophosphatidate.

[0057] Comparative Example 2 2.5 g of the sodium lysophosphatidate-containing material obtained in Synthesis Example 2 and 7.5 g of glycerin were mixed and stirred at 70° C. for 3 hours to obtain a glycerin solution of sodium lysophosphatidate.

[0058] <Irritation evaluation> Aqueous solutions of 1% or 10% concentration were prepared as test solutions for each test substance listed in Table 1. The irritation potential of the resulting test solutions was evaluated using the SIRC-STE method listed in the OECD test guideline (TG491), which is an alternative to the Draize test using rabbits, which has been widely used as a method for evaluating irritation to the eyes and mucous membranes. Test Method Rabbit corneal epithelial derived cells (SIRC) were plated in a 96-well plate at 6.0 × 10 3 Cells were seeded at a concentration of 200 μL per well and cultured for 4 days. After incubation, the medium was removed, and 200 μL of a 5% test solution in saline, a 0.05% test solution in saline, or a control solution in saline was added. After 5 minutes of exposure, the test samples were removed and the cells were washed three times with PBS(-). 200 μL of a 0.5 mg / mL MTT solution was added and incubated for 2 hours. The MTT solution was then removed, and 200 μL of isopropanol containing 0.04 mol / L hydrochloric acid was added to extract formazan for 1 hour. After extraction, the absorbance at 570 nm (OD570) of the extract was measured using a microplate reader, and cell viability was calculated using the average OD570 of three wells using the following formula. The test was performed three times, and the results are shown in Table 1 as the average cell viability for each test.

[0059]

number

[0060] [Table 1]

[0061] The results in Table 1 show that the lysophosphatidate salt of the present invention has higher cell viability and is less irritating than sodium lysophosphatidate used for comparison.

[0062] <Evaluation of physiological activity> Normal human epidermal keratinocytes were plated in a 24-well plate at 1.0 × 10 5Cells were seeded at a concentration of 1000 cells / well and cultured in HuMedia-KB2 medium (Kurabo) for 16 hours. Each test substance listed in Table 1 was then added to the medium at a concentration of 25 ppm, and the cells were cultured for an additional 4 hours. The gene expression levels of various proteins (normalized by GAPDH) were then measured by real-time PCR. As a control, the gene expression levels of various proteins were measured in the same manner without the addition of any test substance. The results are shown in Table 2 as relative values, using the average value of three wells, with the expression level of the control set at 100.

[0063] [Table 2]

[0064] The results in Table 2 demonstrate that the lysophosphatidic acid salt of the present invention significantly increases the gene expression levels of HAS3, CLDN1, CLDN4, OCLN, ZO-2, INV, and TGM compared to the control. The expression levels of CLDN1, CLDN4, OCLN, ZO-2, and TGM were higher than those of the control, sodium lysophosphatidic acid salt. HAS3 is a hyaluronan synthase abundant in the epidermis, and increased HAS3 gene expression promotes hyaluronan production in the epidermis. CLDN1, CLDN4, OCLN, and ZO-2 are proteins that form tight junctions, which mediate cell-to-cell adhesion. Increased gene expression of these proteins promotes tight junction formation. INV is a protein that forms the cornified envelope, an insoluble membrane that surrounds keratinocytes. TGM is an enzyme that acts in the process of cornified envelope formation. Increased gene expression of these proteins promotes cornified envelope maturation.

[0065] The lysophosphatidic acid salt of the present invention was used to prepare the following cosmetic preparation. The obtained cosmetic preparation has excellent moisturizing properties and a penetrating feel, and prevents fine wrinkles and rough skin.

[0066] Example 5 Moisturizing lotion Component Amount (% by weight) -------------------------------------- Part A Glycerin solution of aluminum lysophosphatidate of Example 1 0.5 BG 5.0 1,2-Pentanediol 3.0 Purified water 20.0 Part B Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Glucosylceramide 0.5 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Parts A and B were mixed uniformly at approximately 40°C. A and B were mixed to form a uniform liquid.

[0067] Example 6 Moisturizing lotion Component Amount (% by weight) -------------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 2 3.0 Phenoxyethanol 0.4 Sodium citrate (appropriate amount) Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) All ingredients were mixed at approximately 40°C, and sodium citrate was added to adjust the pH to 6.5-7.0 to make a homogeneous solution.

[0068] Example 7 Moisturizing lotion Component Amount (% by weight) -------------------------------------- Glycerin solution of zinc lysophosphatidate from Example 4 1.0 Phenoxyethanol 0.4 Hydroxyethyl cellulose 0.2 Carbomer 0.1 Arginine 0.2 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) All ingredients were mixed uniformly at about 40°C to form a homogeneous liquid.

[0069] Example 8 Moisturizing lotion Component Amount (% by weight) ------------------------------------- Part A Glycerin solution of aluminum lysophosphatidate of Example 3 0.5 Diglycerin 1.0 Glycerin 8.0 BG 3.0 Plandool-LG2 (Nippon Fine Chemical) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.05 Cholesterol 0.1 Part B Purified water 30.0 C part Maltitol Liquid 1.0 Betaine 0.5 α-glucan oligosaccharide 0.1 Pullulan 0.5 Tuberose polysaccharide 0.01 Hydroxypropyl methylcellulose stearoxy ether 0.05 (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A and B were heated to 70°C, and part A was added to part B while stirring with a homomixer (7000 rpm) to prepare a nano dispersion. The mixture was then dispersed using a high-pressure emulsifier (Mizuho Industrial Microfluidizer). After cooling, pre-mixed part C was added to make a homogeneous liquid.

[0070] Example 9 Moisturizing lotion Component Amount (% by weight) ------------------------------------- Part A Glycerin solution of aluminum lysophosphatidate of Example 3 3.5 Diglycerin 1.0 Glycerin 8.0 Plandool-LG2 (Nippon Fine Chemical) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.05 Phytosterols 0.1 Tocopherol 0.05 Part B Purified water 30.0 C part Betaine 0.5 Nicotinamide 5.0 Tranexamic acid (Nippon Fine Chemical) 1.0 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A and B were heated to 70°C, and part A was added to part B while stirring with a homomixer (7000 rpm) to prepare a nano dispersion. After cooling, pre-mixed part C was added to make a homogeneous liquid.

[0071] Example 10 Moisturizing lotion Component Amount (% by weight) -------------------------------------- Part A Glycerin solution of aluminum lysophosphatidate of Example 1 5.0 BG 2.0 1,2-Pentanediol 3.0 Purified water 20.0 Part B Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Tranexamic acid (Nippon Fine Chemical) 2.0 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Parts A and B were mixed uniformly at approximately 40°C. A and B were mixed to form a uniform liquid.

[0072] Example 11 Moisturizing lotion Component Amount (% by weight) -------------------------------------- Part A Phytopresome-MEL (Nippon Fine Chemical) 0.8 PrimeLipid-PI (Nippon Fine Chemical) 1.0 BG 5.0 Glycerin 10.0 1,2-Hexanediol 3.0 Part B Purified water (amount to make a total of 100) C part Glycerin solution of aluminum lysophosphatidate of Example 1 7.0 Sodium cyclic lysophosphatidic acid 0.001 Neosolue-AquaS (Nippon Fine Chemical) 1.0 PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin 0.5 Polyquaternium-51 0.5 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water 20.0 -------------------------------------- (Preparation method) Parts A and B were heated to 70°C, and part A was added to part B while stirring with a homomixer (7000 rpm) to prepare a nanovesicle solution. After cooling, premixed part C was added to make a homogeneous solution.

[0073] Example 12 Whitening lotion Component Amount (% by weight) -------------------------------------- Glycerin solution of aluminum lysophosphatidate of Example 1 10.0 Glycerin 8.0 1,3-Propanediol 7.0 3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.6 Arbutin (Nippon Fine Chemical) 1.0 Ethanol 3.0 DPG 2.0 Methylgluceth-10 2.0 Glycyrrhizic acid 2K 0.05 Tremoist-TP (Nippon Fine Chemical) 0.01 Xanthan gum 0.05 Phenoxyethanol 0.5 Methylparaben 0.15 Citric acid 0.1 Sodium citrate 0.2 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to form a homogeneous liquid.

[0074] Example 13 Whitening lotion Component Amount (% by weight) -------------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 4 5.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Tranexamic acid (Nippon Fine Chemical) 2.0 Nicotinamide 5.0 Phytic acid 0.2 Purified water 20.0 Part B BG 5.0 Tripropylene Glycol 2.0 Sodium Hyaluronate 0.01 DPG 2.0 Carbomer 0.01 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Part A and Part B were weighed into containers and mixed with a paddle at room temperature to form a homogeneous liquid. Part B was mixed with Part A to form a homogeneous liquid.

[0075] Example 14 Gel lotion Component Amount (% by weight) ------------------------------------- Part A Glycerin solution of aluminum lysophosphatidate of Example 1 3.0 Glycerin 10.0 Sorbitol solution (70%) 5.0 PEG-10 Dimethicone 0.4 Glucose 1.0 BG 3.0 Purified water 20.0 Part B Pullulan 0.2 Ethylhexylglycerin 0.2 Polymethacryloyl lysine 0.05 Crystalline cellulose powder 0.1 Locust bean gum 0.03 Hydroxyethyl cellulose 0.05 Xanthan gum 0.05 Sodium Hyaluronate 0.01 Tranexamic acid (Nippon Fine Chemical) 2.0 Carbomer 0.06 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Part A and Part B were weighed into containers and mixed with a paddle at room temperature to form a homogeneous liquid. Part B was mixed with Part A to form a homogeneous liquid.

[0076] Example 15 Transparent gel Component Amount (% by weight) ------------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 2 2.0 PrimeLipid-PI (Nippon Fine Chemical) 0.2 Glycerin 5.0 PPG-6-decyltetradeceth-30 0.2 PEG-30 Phytosterol 0.3 Purified water 30.0 Part B PEG-4M 0.2 Methylgluceth-10 1.0 Pyridoxine hydrochloride 0.05 Ethylhexylglycerin 0.2 Phenoxyethanol 0.4 Tranexamic acid (Nippon Fine Chemical) 2.0 Tremoist-TP (Nippon Fine Chemical) 0.01 Hydrolyzed Collagen 0.01 Purified water (amount to make a total of 100) (Acrylate dimethyl taurate ammonium / vinyl pyrrolidone) copolymer 0.05 (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.15 Arginine 0.25 -------------------------------------- (Preparation method) Part A and Part B were weighed into containers and mixed with a paddle at room temperature to form a homogeneous liquid. Part B was mixed with Part A to form a homogeneous liquid.

[0077] Example 16 Scalp lotion Component Amount (% by weight) -------------------------------------- Glycerin solution of aluminum lysophosphatidate of Example 1 3.0 Maltitol liquid 0.5 PEG-60 Hydrogenated Castor Oil 0.3 Ethanol 10.0 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Betaine 0.2 Hydroxypropyl chitosan liquid 0.05 Carrot extract 0.1 Pyridoxine hydrochloride 0.05 Panthenol 0.1 Dipotassium glycyrrhizinate 0.1 Phenoxyethanol 0.3 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to form a homogeneous liquid.

[0078] Example 17 Scalp lotion Component Amount (% by weight) ------------------------------------- Glycerin solution of aluminum lysophosphatidate of Example 1 2.0 1,2-Hexanediol 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Tocopheryl acetate 0.05 Menthol 0.1 Betaine 0.2 Swertia japonica extract 0.1 Tamasakizukuraffe Root Extract 0.003 Hinokitiol 0.1 PCA-Na 0.1 Carbomer 0.01 Potassium hydroxide 0.01 Pentetic acid pentasodium 0.05 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to form a homogeneous liquid.

[0079] Example 18 Hair growth agent Component Amount (% by weight) ------------------------------------- Glycerin 2.0 Glycerin solution of zinc lysophosphatidate of Example 2 1.0 PEG-60 Hydrogenated Castor Oil 0.3 Betaine 0.5 Ethanol 20.0 Menthol 0.1 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Orange oil 0.05 Panthenyl ethyl ether 0.2 Carrot Extract 1.0 Sophora Extract 2.0 Chlorella Extract 1.0 Trehalose 0.5 Nicotinamide 1.0 Piroctone Olamine 0.1 Dipotassium glycyrrhizinate 0.1 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to form a homogeneous liquid.

[0080] Example 19 Hair growth agent Component Amount (% by weight) ------------------------------------- Glycerin solution of zinc lysophosphatidate of Example 4 4.0 Phytopresome-MEL (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 0.5 DPG 2.0 Lactic acid 0.1 Tremoist-TP (Nippon Fine Chemical) 0.01 Ethanol 10.0 Menthol 0.1 Menthyl glyceryl ether 0.15 Panthenyl ethyl ether 0.2 Camphor 0.1 Cordyceps extract 1.0 Swertia japonica extract 1.0 Loquat Leaf Extract 1.0 Hydrolyzed hyaluronic acid 0.02 Sodium cyclic lysophosphatidic acid 0.001 Capsicum extract 0.01 Betaine 0.3 Trehalose 0.2 Cymen-5-ol 0.1 Tocopheryl acetate 0.05 β-Glycyrrhetinic acid 0.05 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to form a homogeneous liquid.

[0081] Example 20 Whitening emulsion Component Amount (% by weight) -------------------------------------- Part A Plandool-DP (Nippon Fine Chemical) 1.0 Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0 Cetyl alcohol 1.2 Dimethicone 100cs 3.0 Myristyl Alcohol 2.0 Oleyl alcohol 1.0 Part B Stearoxyhydroxypropylmethylcellulose 0.1 Xanthan gum 0.1 Sodium citrate (appropriate amount) Purified water 20.0 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 Glycerin 8.0 D part 3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5 Tranexamic acid (Nippon Fine Chemical) 2.0 Nicotinamide 5.0 Glycerin solution of zinc lysophosphatidate of Example 2 1.0 Purified water 5.0 Part E Phenoxyethanol 0.2 Methylparaben 0.15 Phytic acid 0.5 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Parts A and E were heated to approximately 70°C and dissolved uniformly. Part B was stirred to form a viscous liquid. Part C was heated to approximately 70°C and dispersed uniformly. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Parts D and B were added at approximately 50°C, and the mixture was mixed uniformly by stirring, and the pH was adjusted to 6.5-7.0 with sodium citrate.

[0082] Example 21 Emulsion Component Amount (% by weight) ------------------------------------- Part A Glycerin 3.0 Diglycerin 1.0 BG 5.0 Phytocompo-C (Nippon Fine Chemical) 1.5 Part B Triethylhexanoin (Nippon Fine Chemicals) 3.0 LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.5 Hydrogenated polyisobutene 3.5 Isododecane 1.5 Cetostearyl Alcohol 1.0 Arachyl alcohol 0.1 Jojoba Alcohol 3.0 Chimyl alcohol 0.3 Selachyl alcohol 0.1 Hexyldecanol 0.5 C part (Hydroxyethyl acrylate / Sodium acryloyldimethyl taurate) copolymer 0.2 Tremoist-TP (Nippon Fine Chemical) 0.03 Carbomer 0.1 Potassium hydroxide 0.2 Purified water 30.0 D part Neosolue-AquaS (Nippon Fine Chemical) 0.5 Polyquaternium-51 1.0 Glycerin solution of zinc lysophosphatidate from Example 4 1.0 Tranexamic acid (Nippon Fine Chemical) 2.0 Nicotinamide 5.0 Methylparaben 0.15 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to approximately 70°C, and then uniformly dissolved and dispersed. Part C was added and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added and emulsified. After cooling to approximately 50°C, Part C was added and stirred, and the mixture was cooled to approximately 40°C.

[0083] Example 22 Skin Care Cream Component Amount (% by weight) ------------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 2 1.0 Sodium cyclic lysophosphatidic acid 0.01 Glycerin 9.0 DPG 5.0 Tripropylene Glycol 2.0 Sucrose stearate 1.5 Part B (C13-15) Alkanes 8.0 Vaseline 10.0 Pentaerythrityl tetraisostearate 5.0 Astaxanthin 0.01 Cetyl PG Hydroxyethyl Palmitamide 0.05 Dipentaerythrityl hexahydroxystearate 1.0 C part Carbomer 0.1 Tranexamic acid (Nippon Fine Chemical) 2.0 Xanthan gum 0.1 Purified water 10.0 D part Phenoxyethanol 0.4 Ethylhexylglycerin 0.2 Methylparaben 0.05 Nicotinamide 5.0 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to approximately 70°C, and then uniformly dissolved and dispersed. Part C was added and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added and emulsified. After cooling to approximately 50°C, Part C was added and stirred, and the mixture was cooled to approximately 40°C.

[0084] Example 23 Skin Care Cream Component Amount (% by weight) ------------------------------------- Part A Sugar Squalane 10.0 Stearic Acid 1.0 Plandool-ISS (Nippon Fine Chemical) 1.0 Macadamia nut oil 3.0 Hydrogenated rapeseed oil alcohol 2.0 Olive oil fatty acid cetearyl 1.0 Sorbitan olive oil fatty acids 0.8 Polyglyceryl-10 Oleate 1.0 Part B Acrylic acid / alkyl methacrylate copolymer 0.1 Potassium hydroxide 0.1 (Ammonium acryloyldimethyltaurate / Beheneth-25 Methacrylate Crosspolymer 0.2 Tremoist-SL (Nippon Fine Chemical) 1.0 Glycerin solution of aluminum lysophosphatidate of Example 3 0.5 Purified water 20.0 Hydrolyzed poly-γ-glutamic acid K 0.1 Sodium Polyglutamate 0.1 Oligopeptide-24 0.05 C part PrimeLipid-PI (Nippon Fine Chemical) 1.0 Propanediol 10.0 PEG-8 5.0 PEG-2M 2.0 Glyceryl Caprylate 0.8 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A and C were mixed and heated to approximately 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to form a viscous liquid. Part A was added to Part C while stirring with a homomixer to emulsify. After cooling to approximately 50°C, Part B was added and stirred to cool to approximately 40°C.

[0085] Example 24 Skin Care Cream Component Amount (% by weight) ------------------------------------- Part A Plandool-MAS (Nippon Fine Chemical) 2.0 Plandool-LG1 (Nippon Fine Chemical) 1.0 Paraffin Wax 3.0 Shea Butter 3.0 Squalane 8.0 Cetyl alcohol 1.8 Hydrogenated Cocoglycerides 0.8 Glyceryl stearate 1.0 Behenyl Alcohol 1.5 Sorbitan stearate 1.0 Polyglyceryl-10 Laurate 1.0 PEG-60 Glyceryl Isostearate 1.0 Methyl glucose sesquistearate 1.5 Part B Xanthan gum 0.1 Hydroxyethyl cellulose 0.1 Crystalline cellulose powder 0.3 Stearoxyhydroxypropylmethylcellulose 0.1 Tranexamic acid (Nippon Fine Chemical) 1.0 Purified water 20.0 C part Glycerin 8.0 DPG 5.0 Sorbitol 2.0 Glycerin solution of aluminum lysophosphatidate of Example 1 2.5 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Methylparaben 0.15 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A and C were mixed and heated to approximately 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to form a viscous liquid. Part A was added to Part C while stirring with a homomixer to emulsify. After cooling to approximately 50°C, Part B was added and stirred to cool to approximately 40°C.

[0086] Example 25 Skin Care Cream Component Amount (% by weight) ------------------------------------- Part A Glycerin 12.0 BG 3.0 Phytocompo-PP (Nippon Fine Chemical) 2.5 Part B Olive Fruit Oil 3.0 1.5 tablespoons olive oil Shea butter 1.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 3.0 Sucrose stearate 0.8 Cetearyl Glucoside 1.2 Behenyl Alcohol 1.5 Ascorbyl Tetrahexyldecanoate 7.0 Isopropyl Lauroyl Sarcosinate 2.0 Hydrogenated Cocoglycerides 3.0 Cetyl alcohol 2.5 Sorbitan stearate 0.8 C part Xanthan gum 0.05 Tremoist-SL (Nippon Fine Chemical) 1.0 Tuberose polysaccharide 0.01 Water-soluble collagen 0.05 Hydrolyzed Collagen 0.5 Sodium pyrosulfite 0.03 Glycerin solution of aluminum lysophosphatidate of Example 3 3.5 Arbutin (Nippon Fine Chemical) 1.0 Tranexamic acid (Nippon Fine Chemical) 1.0 Purified water 10.0 D part Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Propanediol 3.0 Methylparaben 0.1 Glyceryl Caprylate 1.0 Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to approximately 70°C, and then uniformly dissolved and dispersed. Part C was added and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added and emulsified. After cooling to approximately 50°C, Part C was added and stirred, and the mixture was cooled to approximately 40°C.

[0087] Example 26 Skin Care Cream Component Amount (% by weight) ------------------------------------ Part A Neosolue-DiSM (Nippon Fine Chemicals) 5.0 Jojoba oil 2.0 Plandool-H (Nippon Fine Chemical) 1.0 Neosolue-MCT (Nippon Fine Chemical) 3.0 LUSPLAN DD-DHR (Nippon Fine Chemical) 1.0 Plandool-SUN (Nippon Fine Chemical) 1.3 Propylene glycol stearate 0.6 Squalane 3.0 Behenyl Alcohol 2.0 Liquid isoparaffin 0.5 Carnauba wax 0.3 Corn oil 0.3 Rapeseed oil 1.0 Sunflower oil 1.0 wheat germ oil 1.0 Linseed oil 0.1 Cottonseed oil 0.1 Soybean oil 0.1 Shea butter 0.5 Stigmasterol 1.0 Stigmastanol 1.0 Dihydrocholesterol 0.1 Lanosterol 0.1 Dihydrolanosterol 0.1 Cholesteryl nonanoate 0.1 Cholesteryl stearate 0.1 Cholesteryl Isostearate 1.0 Cholesteryl oleate 0.1 Cholesteryl 12-hydroxystearate 0.1 Long-chain branched fatty acid cholesteryl 0.3 Octyldodecyl myristate 1.0 Octyldodecyl isostearate 1.0 Hydrogenated Castor Oil Dimer Dilinoleate 1.0 Hydroxyalkyl dimer dilinoleyl ether 1.0 Dipentaerythrityl tetrahydroxystearate / isostearate 0.5 Rice bran oil fatty acid phytosteryl 0.5 Phenyl Trimethicone 1.0 Diphenyl Dimethicone 1.0 Methylhydrogenpolysiloxane 1.0 Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone 0.5 Dimethicone 50cs 0.3 Polyoxyethylene-methylpolysiloxane copolymer 1.0 Tocopheryl Ferulate 0.1 Tocopheryl phosphate 0.1 Tocotrienol 0.1 Tannins 0.01 Sesamin 0.01 Proanthocyanidins 0.01 Glabridin 0.01 Grablen 0.01 Liquiritin 0.01 Isoliquiritin 0.01 Lactoferrin 0.01 Gingerol 0.01 Gingerol 0.01 Part B (Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer 0.2 Microcrystalline cellulose 0.1 Gellan gum 0.1 Carboxyvinyl polymer 0.1 Potassium hydroxide 0.08 Purified water 20.0 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 Glycerin solution of aluminum lysophosphatidate of Example 1 0.5 Polyglyceryl-10 Stearate 0.5 Glycerin 7.0 DPG 7.0 D part Citric acid 0.07 Sodium citrate (appropriate amount) EDTA-2Na 0.05 Pentetic acid pentasodium 0.03 Phenoxyethanol 0.4 Purified water (amount to make a total of 100) -------------------------------------- (Preparation method) Part A was mixed and heated to about 70°C and dissolved uniformly. Part B was mixed and stirred to form a viscous liquid. Part C was mixed and heated to about 70°C and dispersed uniformly. Part D was mixed and heated to about 70°C and dissolved uniformly. Part A was added to part C while stirring with a homogenizer, and then part D was added and emulsified. After cooling to about 50°C, part B was added and stirred to dissolve uniformly.

[0088] Example 27 Skin Care Cream Component Amount (wt%) ------------------------------------- Part A Plandool-G (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 1.5 Diethylhexyl sebacate (Nippon Fine Chemical) 8.0 Diisopropyl sebacate (Nippon Fine Chemical) 2.0 Theobroma grandiflorum seed oil 3.0 Batyl Isostearate 2.0 Shea Butter 3.0 (Dimethicone / vinyl dimethicone) crosspolymer 0.3 (Vinyl dimethicone / lauryl dimethicone) crosspolymer 0.5 (Dimethicone / PEG-10 / 15) Crosspolymer 0.5 (PEG-15 / Lauryl Dimethicone) Crosspolymer 0.2 (Alkyl acrylate / Dimethicone) Copolymer 0.1 Isostearyl pivalate 0.1 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 0.1 Stearyl alcohol 3.5 Cetyl alcohol 1.3 Palm Fatty Acid Sucrose 1.0 Polyglyceryl-3 Methylglucose Distearate 0.8 Tri-fatty acid (C10-18) glyceryl 3.0 Squalane 3.0 Dimethicone 100cs 1.0 Tocopherol 0.1 Ascorbyl Tetrahexyldecanoate 8.0 Tocopheryl Ascorbyl Phosphate 2.0 Placenta extract 1.0 Oryzanol 0.3 Phytosphingosine 0.0001 Ubiquinone 0.03 Carotene 0.05 Lycopene 0.01 Astaxanthin 0.01 Lutein 0.01 Fullerene 0.001 Peanut oil 0.1 Rice bran oil 1.0 Hydrogenated castor oil 0.3 Jojoba oil 2.0 Orange Roughy Oil 1.0 Liquid lanolin (Nippon Fine Chemical) 1.0 Lanolin (Nippon Fine Chemical) 1.0 Polyoxyethylene Lanolin 1.0 Lanolin alcohol (Nippon Fine Chemical) 0.3 Lanolin Alcohol Acetate 0.1 Cholesteryl acetate 0.1 Octocrylene 0.5 Sorbitan sesquistearate 1.2 Part B Tremoist-TP (Nippon Fine Chemical) 0.05 Water-soluble collagen 0.05 Hydrolyzed Collagen 0.5 Glutathione 0.3 Arbutin (Nippon Fine Chemical) 3.0 Nicotinamide 5.0 C part Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Propanediol 10.0 PPG-9 Diglyceryl 2.0 Diglycerin 1.0 Sodium pyrosulfite 0.1 Imidazolinium urea 0.1 Polyvinylpyrrolidone 0.1 Pullulan 0.1 Polyvinyl alcohol 0.1 Dehydroacetic acid 0.1 PEG-32 1.0 Polyglycerin-10 1.0 Pentetic acid pentasodium 0.05 Phenoxyethanol 0.4 1,2-Pentanediol 2.0 Succinic acid 0.05 Sodium succinate (appropriate amount) Purified water (amount to make a total of 100) ------------------------------------- (Preparation method) Part A was heated to approximately 70°C and dissolved uniformly. Part B was homogenized using some of the purified water. Part C was heated to approximately 70°C and dispersed. While stirring with a homomixer at approximately 70°C, part A was gradually added to part C and emulsified. After cooling to approximately 40°C, part B was added and mixed uniformly, and the pH was adjusted to 6.5-7.0 with sodium succinate.

[0089] Example 28 Emulsion Component Amount (wt%) ---------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 10.0 Lysolecithin (Nippon Fine Chemical) 0.1 Glycerin solution of zinc lysophosphatidate from Example 2 3.5 Part B Squalane 4.0 Neosolue-MCT (Nippon Fine Chemical) 4.0 α-olefin oligomer 2.5 Dimethicone 5cs 3.5 Cetyl alcohol 1.5 Glyceryl stearate 1.0 C part Hydroxyproline 0.05 Citric acid 0.01 Sodium citrate 0.09 Arbutin (Nippon Fine Chemical) 3.0 Phenoxyethanol 0.3 Methylparaben 0.1 Acrylic acid / alkyl methacrylate copolymer 0.1 Potassium hydroxide 0.1 Purified water (amount to make a total of 100) ----------------------------------- (Preparation method) Parts A to C were each heated to approximately 70°C and mixed uniformly. Part B was gradually added to part A while stirring with a homodisper, and then part C was added at approximately 70°C to emulsify. The mixture was then cooled to approximately 40°C.

[0090] Example 29 Cleansing Gel Component Amount (wt%) --------------------------------- Part A Glycerin solution of zinc lysophosphatidate from Example 2 2.5 1,2-Pentanediol 1.0 Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0 Plandool-S (Nippon Fine Chemical) 1.0 Dihydrocholesterol-30 (Nippon Fine Chemical) 2.0 LUSPLAN DD-IS (Nippon Fine Chemical) 8.0 PEG-25 Hydrogenated Castor Oil 20.0 Octyldodeceth-20 15.0 Glycerin 16.0 BG 5.0 Part B Phenoxyethanol 0.5 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. Part B was heated to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

[0091] Example 30 Cleansing Cream Component Amount (wt%) --------------------------------- Part A Plandool-LG2 (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Ceresin 6.0 Glycerin solution of zinc lysophosphatidate of Example 2 0.5 PEG-12 Isostearate 3.0 Sorbitan Sesquioleate 1.5 Polyoxyethylene sorbitan oleate 0.3 Polyglyceryl-10 Laurate 0.3 Microcrystalline Wax 2.0 Tocopherol 0.05 Part B Neosolue-Aqua (Nippon Fine Chemical) 0.5 DPG 5.0 Disodium edetate 0.02 Phenoxyethanol 0.5 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. Part B was heated to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

[0092] Example 31 Facial cleanser Component Amount (wt%) --------------------------------- Part A Glycerin solution of zinc lysophosphatidate from Example 2 1.0 (Coconut Fatty Acid / Hydrogenated Beef Fatty Acid) Sodium Glutamate 30.0 Cocoyl glycine potassium 5.0 Plandool-LG2 (Nippon Fine Chemical) 0.2 Lauric acid diethanolamide 3.0 Tocopherol 0.1 PEG-8 5.0 PEG-32 10.0 Glycerin 14.0 Part B Glyceryl Caprylate 1.0 Hexanediol 1.0 Polyquaternium-51 1.0 Tremoist-SL (Nippon Fine Chemical) 0.5 Microcrystalline cellulose 0.3 Polyquaternium-7 0.8 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. Part B was heated to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C.

[0093] Example 32 Body Shampoo Component Amount (wt%) --------------------------------- Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Sodium Methyl Cocoyl Taurate 10.0 Lauroyl Hydrolyzed Silk Sodium 6.0 Sodium Lauroyl Methylalanine 10.0 Sodium Cocoamphoacetate (30%) 4.0 Cocamidopropyl Betaine (30%) 10.0 Sodium Olefin (C14-16) Sulfonate 5.0 Polyquaternium-10 1.3 Guar Hydroxypropyltrimonium Chloride 0.8 Sodium acetyl hyaluronate 0.02 Cocamide DEA 3.0 Glycerin 5.0 Methylparaben 0.2 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) All ingredients were heated to about 80°C and stirred until homogeneous.

[0094] Example 33: Non-silicone shampoo Component Amount (wt%) --------------------------------- Glycerin solution of zinc lysophosphatidate from Example 4 1.0 Plandool-LG2 (Nippon Fine Chemical) 0.03 Neosolue-AquaS (Nippon Fine Chemical) 0.1 Tremoist-SL (Nippon Fine Chemical) 0.5 Sodium Laureth-4 Carboxylate (28%) 10.0 Laureth-6 Carboxylic Acid 4.0 Cocamidopropyl Betaine (30%) 10.0 Sodium Lauroyl Methylalanine (30%) 5.0 Cocamidomethyl MEA 3.0 PEG-7 Glyceryl Cocoate 5.0 Sodium hydroxide 1% solution 0.5 Polyquaternium-10 0.8 Glycol distearate 0.5 Polyquaternium-7 0.5 EDTA-2Na 0.05 Phenoxyethanol 0.4 Sodium benzoate 0.2 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) All ingredients were heated to about 80°C and stirred until homogeneous.

[0095] Example 34 Hand soap Component Amount (wt%) -------------------------------- Part A Sodium cocoyl isethionate 1.0 Glycerin 50.0 Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Part B Sodium Lauroyl Sarcosinate 12.0 Sodium Myristoyl Methyl Taurate 2.0 Polyglyceryl-6 Laurate 2.0 Coconut oil fatty acid diethanolamide 2.0 PEG-7 Coco-Oleate Glyceryl 2.0 Sorbitol 8.0 Hydrolyzed conchiolin 0.1 1,3-butylene glycol 8.0 Phenoxyethanol 0.8 Ethanol 3.0 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. Part B was added to part A, heated to about 80°C, dissolved uniformly, and then cooled.

[0096] Example 35 Leave-in hair treatment Component Amount (wt%) ------------------------------------- Part A Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Polyquaternium-37 2.0 Squalane 2.0 PPG-3 Caprylyl Ether 2.0 Microcrystalline wax 0.1 Lanolin alcohol 0.2 Montan wax 0.1 Polyethylene wax 0.1 Rowlet 0.2 Ceresin 0.1 PG Dicaprate 1.0 Almond oil 0.5 Ethylhexyl ethylhexanoate 1.0 Candelilla wax extract 0.1 Octyldodecyl erucate 4.5 Tocopheryl acetate 0.02 Erucalactone MCT (Nippon Fine Chemical) 2.0 Dipentaerythrityl Tri-Polyhydroxystearate 1.5 PPG-5 Phytosteryl 0.5 Glycerin 4.0 Sorbitol 2.0 Phenoxyethanol 0.5 Part B Hydrolyzed Hyaluronic Acid 0.1 Panthenol 0.1 Hyaluronic acid hydroxypropyltrimonium 0.01 Polyquaternium-11 0.2 Glycosyltrehalose 0.1 Glyceryl glucoside 0.3 Arginine 0.1 C part Purified water (amount to make a total of 100) Hydroxypropyl Starch Phosphate 1.0 -------------------------------------- (Preparation method) Part C was dispersed uniformly and heated to about 80°C. Next, part A was heated to about 80°C and dissolved. Part A was added to part C while stirring, and after uniform mixing, the mixture was cooled to about 40°C. Next, part B was added to each mixture and mixed uniformly.

[0097] Example 36 Leave-in scalp / hair treatment Component Amount (wt%) -------------------------------------- Part A Glycerin solution of zinc lysophosphatidate from Example 2 1.5 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Ethanol 40.0 Glycyrrhetinic acid 0.02 Erucalactone DES (Nippon Fine Chemical) 1.5 PEG / PPG-20 / 20 Dimethicone 0.2 PEG-12 Dimethicone 0.4 Hydrogenated Retinol 0.1 Pyridoxine trishexyldecanoate 0.05 Bisglyceryl ascorbate 0.3 Hexyl 3-glyceryl ascorbate 0.3 Part B Triethanolamine 0.1 Purified water (amount to make a total of 100) (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.4 Carbomer 0.05 Tremoist-SL (Nippon Fine Chemical) 1.0 (Acryloyldimethyltaurate ammonium / VP) copolymer 0.05 (Ammonium acryloyldimethyltaurate / Beheneth-25 Methacrylate Crosspolymer 0.1 Hydroxypropyl chitosan 0.1 Methylparaben 0.1 Phenoxyethanol 0.2 C part 3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5 Nicotinamide 3.5 Pyridoxine hydrochloride 0.1 Caffeine 0.1 Glucosyltrehalose 0.1 Purified water 10.0 ---------------------------------------- (Preparation method) Part A was heated to about 50°C and dissolved. Next, part B was uniformly dispersed to form a viscous liquid. Part A was added to part B while stirring and mixed uniformly. Next, part C was added and mixed uniformly.

[0098] Example 37 Shampoo Component Amount (wt%) ---------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 2 3.0 PPG-3 Caprylyl Ether 0.2 Ammonium Laureth Sulfate 5.0 Sodium laureth sulfate (25%) 10.0 Lauryl Hydroxysultaine (30%) 10.0 Potassium laurate 1.0 Glycol distearate 0.5 Toluenesulfonic acid 0.3 Stearoxypropyldimethylamine 0.5 PPG-17 0.3 Dimethicone 0.1 PEG-9 Dimethicone 0.1 Amodimethicone 0.1 Diethylhexyl sebacate (Nippon Fine Chemical) 1.0 Neopentyl glycol diethylhexanoate 0.4 Lanolin Fatty Acids 0.3 Isodecyl glyceryl ether 0.4 Miconazole nitrate 0.75 Cocamide MEA 1.0 Laureth-4 0.3 Laureth-16 0.2 Steareth-6 0.2 Phenoxyethanol 0.3 Part B Malic acid 0.1 Methylparaben 0.2 Phosphoric acid 0.03 Sodium benzoate 0.3 Arginine 0.4 Purified water (amount to make a total of 100) C part Polyquaternium-10 0.2 Guar Hydroxypropyltrimonium Chloride 0.1 Tremoist-SL (Nippon Fine Chemical) 3.0 Purified water 6.7 ---------------------------------- (Preparation method) Part A was mixed uniformly at about 80°C. Part B, which had been set aside, was heated to about 60°C and homogenized. Part B was gradually added to Part A while stirring, and after mixing uniformly, the mixture was cooled to about 50°C. Part C was then added and mixed uniformly.

[0099] Example 38 Leave-on Hair Treatment Component Amount (wt%) ---------------------------------- Part A Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 2.0 Cetyl alcohol 3.8 Caprylyl Glucoside (50%) 1.5 Glycerin 4.0 Phenoxyethanol 0.5 Part B Ethanol 5.0 C part Polyquaternium-6 0.6 Polyquaternium-7 0.4 Polyquaternium-39 0.5 Purified water (amount to make a total of 100) ---------------------------------- (Preparation method) Part C was heated to about 80°C and dissolved. Next, part A was heated to about 80°C and dissolved. Part A was added to part C while stirring, and after uniformly mixing, the mixture was cooled to about 40°C. Next, part B was added and mixed uniformly.

[0100] Example 39 Lipstick Component Amount (wt%) --------------------------------- Glycerin solution of zinc lysophosphatidate of Example 2 0.5 LUSPLAN SR-DM4 (Nippon Fine Chemical) 7.0 Hydrogenated polyisobutene 5.0 Triethylhexanoin (Nippon Fine Chemicals) 10.0 Neosolue-MCT (Nippon Fine Chemical) - total amount equals 100 Dialkyl carbonate (C14, 15) 3.0 Dextrin palmitate 0.9 Sodium stearoyl lactylate 0.9 Cetyl ethylhexanoate (Nippon Fine Chemical) 24.0 Dimethicone 50cs 5.0 Plandool-MAS (Nippon Fine Chemical) 2.0 Ceresin 8.5 Candelilla Wax 4.0 Sorbitan sesquioleate 0.15 Hydrogen Dimethicone 2.0 Ethanol 0.1 Tocopherol 0.5 Nylon-12 2.0 (Ethylene / propylene) copolymer 0.5 Ba sulfate 1.0 Iron Oxide 2.0 Mica 2.0 Titanium dioxide 1.0 --------------------------------- (Preparation method) All ingredients were heated, stirred and mixed uniformly, then filled into a mold and rapidly cooled.

[0101] Example 40 Lip balm Component Amount (wt%) --------------------------------- Plandool-H (Nippon Fine Chemical) 10.0 Plandool-LG3 (Nippon Fine Chemical) 5.0 Polyglyceryl-2 Diisostearate 15.0 Glycerin solution of zinc lysophosphatidate of Example 2 4.0 Squalane (amount totaling 100) 12-Hydroxystearic acid 5.0 Silica Silylate 3.0 Menthol 0.5 Fragrance (appropriate amount) Antioxidant (appropriate amount) --------------------------------- (Preparation method) All ingredients were heated to about 90°C, mixed uniformly, and then cooled.

[0102] Example 41 Foundation Component Amount (wt%) --------------------------------- Plandool-S (Nippon Fine Chemical) 1.0 Plandool-G (Nippon Fine Chemical) 0.1 Plandool-SUN (Nippon Fine Chemical) 0.1 Plandool-MAS (Nippon Fine Chemicals) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.1 Glycerin solution of zinc lysophosphatidate of Example 4 2.0 Cyclomethicone 3.5 Trimethylsiloxysilicate 1.5 Talc 24.0 Iron oxide 1.9 Titanium dioxide 20.0 Tocopherol 0.1 Ethylhexyl methoxycinnamate 1.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Phenoxyethanol 0.4 Mica Amount that totals 100 ----------------------------------- (Preparation method) All ingredients were stirred and mixed uniformly, and then molded.

[0103] Example 42 Solid Powder Foundation Component Amount (wt%) --------------------------------- Part A Plandool-H (Nippon Fine Chemical) 2.0 YOFCO MAC (Nippon Fine Chemical) 0.1 Plandool-LG1 (Nippon Fine Chemical) 0.1 Plandool-LG2 (Nippon Fine Chemical) 0.1 Plandool-LG4 (Nippon Fine Chemical) 0.1 LUSPLAN PI-DA (Nippon Fine Chemical) 3.0 Cetyl ethylhexanoate (Nippon Fine Chemical) 3.0 Glycerin solution of zinc lysophosphatidate of Example 2 3.0 Squalane 1.6 Part B Lecithin-treated sericite 20.0 Boron nitride 10.0 Mica 3.0 Silica 2.0 Dimethicone 3.0 Nylon-12 3.0 Talc 10.0 Titanium dioxide 10.0 Iron oxide: Amount that adds up to 100 --------------------------------- (Preparation method) Part A was heated and mixed. Part B was placed in a separate container and mixed and dispersed. Part A was added to Part B, and after mixing uniformly, it was molded.

[0104] Example 43 Liquid Foundation Component Amount (wt%) --------------------------------- Part A Glycerin solution of zinc lysophosphatidate of Example 2 7.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Octyltriazone 1.5 Ethylhexyl methoxycinnamate 1.0 Quaternium-18 Hectorite 0.5 Part B Cyclomethicone 25.0 Polyether modified silicone mixture 5.0 (BY22-008M manufactured by Toray Dow Corning Silicone Co., Ltd.) Polyglyceryl-2 Isostearate 1.0 Titanium dioxide and iron oxide mixture 12.5 Mica 6.0 C part Glycerin 5.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Methylparaben 0.2 Tranexamic acid (Nippon Fine Chemical) 2.0 Purified water (amount to make a total of 100) --------------------------------- (Preparation method) Part A was heated to about 80°C and thoroughly dispersed. Part B, which had been heated to about 80°C, was added to this, and then part C, which had also been heated to about 80°C, was added. The mixture was emulsified and dispersed using a homogenizer and cooled to room temperature with stirring.

[0105] Example 44 Foundation Component Amount (wt%) ------------------------------------ Part A Glycerin solution of zinc lysophosphatidate from Example 2 1.0 Isododecane 10.0 Neosolue-MCT (Nippon Fine Chemical) 4.0 Ethylhexyl methoxycinnamate 3.0 Plandool-SUN (Nippon Fine Chemical) 1.0 Plandool-LG2 (Nippon Fine Chemical) 1.0 Plandool-LG4 (Nippon Fine Chemical) 1.0 Vaseline 1.0 Isotridecyl isononanoate 2.0 Ascorbyl tetrahexyldecanoate 0.1 Dextrin palmitate 0.3 Sorbitan Isostearate 1.5 Tribehenin 0.5 (Butyl acrylate / glycol dimethacrylate) crosspolymer, silica, (Methyl methacrylate / glycol dimethacrylate) crosspolymer mixture 2.0 Boron nitride 1.0 Polysorbate 20 2.0 PEG-60 Hydrogenated Castor Oil 1.0 Disteardimonium Hectorite (20%) 2.5 Polypropylsilsesquioxane, cyclopentasiloxane mixture 1.0 Mica 15.0 Talc 4.0 Zinc oxide 5.0 Titanium dioxide 10.0 Iron oxide 1.5 Part B Water - Amount that totals 100 DPG 4.0 Maltitol (75% liquid) 1.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Sodium chloride 1.0 BG 1.0 Tremoist-SL (Nippon Fine Chemical) 1.0 Ethanol 0.5 Phenoxyethanol 0.3 ------------------------------------ (Preparation method) Part A was heated to about 70°C and stirred thoroughly to disperse uniformly. Part B was heated to about 70°C and homogenized, then part B was added to part A, stirred at about 70°C to emulsify, and cooled to about 40°C.

[0106] Example 45 Sunscreen Cosmetic Component Amount (wt%) ----------------------------------- Part A FINEX-33W (Sakai Chemical Industry) 5.0 STR-100W (Sakai Chemical Industry) 5.0 Purified water (amount to make a total of 100) BG 7.0 Disodium edetate 0.05 Triethanolamine 1.0 Part B Oxybenzone 3.0 Octyl para-methoxycinnamate 5.0 t-Butyl methoxybenzoylmethane 3.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Glycerin solution of zinc lysophosphatidate of Example 2 3.0 Diethylhexyl sebacate (Nippon Fine Chemical) 8.0 Plandool-H (Nippon Fine Chemical) 2.0 Plandool-SUN (Nippon Fine Chemical) 2.0 Plandool-MAS (Nippon Fine Chemicals) 0.1 Plandool-LG1 (Nippon Fine Chemical) 0.1 Plandool-LG2 (Nippon Fine Chemical) 0.1 Plandool-LG3 (Nippon Fine Chemical) 0.1 Plandool-LG4 (Nippon Fine Chemical) 0.1 LUSPLAN PI-DA (Nippon Fine Chemical) 3.0 Cetyl ethylhexanoate (Nippon Fine Chemical) 3.0 Diisopropyl sebacate (Nippon Fine Chemical) 5.0 Dimethicone 2cs 5.0 Sucrose stearate 1.5 Polyglyceryl Stearate-10 2.0 Stearyl Alcohol 3.0 Batyl alcohol 1.0 Stearic Acid 3.0 Glyceryl Monostearate 1.0 Polyethyl acrylate 1.0 Phenoxyethanol 0.5 ----------------------------------- (Preparation method) Part A was heated to about 80°C and thoroughly dispersed. Part B, which had been heated to about 80°C, was added to this, emulsified and dispersed using a homogenizer, and then cooled to room temperature with stirring.

[0107] Example 46 Sunscreen Cosmetic Component Amount (wt%) ----------------------------------- Part A BG 10.0 Glycerin 9.0 Phytocompo-PP (Nippon Fine Chemical) 1.0 Octocrylene 4.0 Octyl Salicylate 4.0 Diethylaminohydroxybenzoylhexyl benzoate 2.25 t-Butyl methoxydibenzoylmethane 1.0 Diethylhexyl sebacate (Nippon Fine Chemical) 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 2.0 Diisopropyl sebacate (Nippon Fine Chemical) 1.0 Behenyl Alcohol 2.0 Cetearyl Alcohol 2.0 Plandool-MAS (Nippon Fine Chemical) 1.0 Tocopherol 0.05 Part B Neosolue-AquaS (Nippon Fine Chemical) 1.0 Methylparaben (appropriate amount) Water - Amount that totals 100 C part Carbomer (2%) 5.0 Tremoist-SL (Nippon Fine Chemical) 10.0 DIS-AB-10W (Sakai Chemical Industry) 5.0 Glycerin solution of zinc lysophosphatidate of Example 2 0.2 ----------------------------------- (Preparation method) Heat and dissolve parts A and B at approximately 70°C. Gradually add part B to part A and emulsify. Cool while stirring, and mix with part C at 45°C.

[0108] Example 47 Cosmetic Oil Component Amount (wt%) ---------------------------------- Neosolue-DiSM (Nippon Fine Chemicals) - Amount that makes a total of 100 Glycerin solution of zinc lysophosphatidate of Example 2 2.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Octyldodecanol 40.0 Plandool-LG2 (Nippon Fine Chemical) 3.0 Ceramide 2 1.0 Ceramide 5 1.0 Cholesterol 5.0 Preservatives (appropriate amount) ---------------------------------- (Preparation method) All ingredients were mixed with stirring at about 90°C and then allowed to cool.

[0109] In the above prescription, details of the ingredients listed by product name are as follows: Plandool-H: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-S: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-G: Dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate Plandool-DP: Bis-diglyceryl polyacyladipate-2 Plandool-ISS: Phytosteryl isostearate Plandool-SUN: Sunflower seed oil fatty acid phytosteryl Plandool-MAS: Macadamia nut oil fatty acid phytosteryl Plandool-LG1: Phytosteryl / Octyldodecyl / Behenyl Lauroyl Glutamate Plandool-LG2: Phytosteryl / Octyldodecyl Lauroyl Glutamate Plandool-LG3: Phytosteryl / Octyldodecyl / Behenyl Lauroyl Glutamate Plandool-LG4: Phytosteryl / Octyldodecyl / Behenyl Lauroyl Glutamate LUSPLAN DD-IS: Dimer dilinoleyl diisostearate LUSPLAN PI-DA: Diisostearyl / Phytosteryl Dimer Dilinoleate LUSPLAN DD-DHR: Dimer dilinoleyl hydrogenated rosin condensate LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, caprylic / capric triglyceride Neosolue-Aqulio: bisethoxydiglycol cyclohexanedicarboxylic acid Neosolue-Aqua: Polyglyceryl-10 (eicosanedioate / tetradecanedioate), glycerin Neosolue-AquaS: Polyglyceryl-10 (eicosanedioate / tetradecanedioate), glycerin Neosolue-DiSM: Diisostearyl malate Neosolue-MCT: ​​Caprylic / Capric Triglyceride Phytocompo-PP: Hydrogenated lecithin, phytosterol Phytocompo-C: Hydrogenated lecithin, phytosterol, ceramide 2, ceramide 3, ceramide 6II Phytocompo-SP: Hydrogenated lecithin, phytosterol, BG, glycerin Phytopresome MEL: glycolipids, hydrogenated lecithin, BG, purified water Erucalactone MCT: γ-docosalactone, caprylic / capric triglyceride Erucalactone DES: γ-docosalactone, diethyl sebacate Tremoist-TP: Tremella fuciformis polysaccharide Tremoist-SL: Tremella fuciformis polysaccharide aqueous solution (1%) YOFCO MAC: Macadamia nut oil fatty acid cholesteryl PrimeLipid-PI: Hydrogenated lecithin, phytosterol, lecithin, tocopherol STR-100W: Titanium oxide, hydrated silica FINEX-33W: Zinc oxide, hydrated silica DIS-AB-10W: Titanium dioxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone

Claims

[Claim 1] A cosmetic or topical skin preparation containing a salt of lysophosphatidic acid represented by the following general formula (1) or (2) with zinc or aluminum. 【Chemistry 1】 (wherein R1 represents a saturated or unsaturated aliphatic acyl group having 14 to 24 carbon atoms.) 【Chemistry 2】 (wherein R2 represents a saturated or unsaturated aliphatic acyl group having 14 to 24 carbon atoms.)

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