Oral components

Abstract

Provided is an oral cavity composition that is configured such that unpleasant taste and irritation resulting from component (A), (B) or (C) are masked and suppressed, that provides a natural, deep, and unique refreshing feeling, and that has an excellent feeling of use.　The oral cavity composition comprises: at least one component selected from among (A)-(C), (A) at least one selected from potassium salt (A-1) and a water-soluble multivalent metal salt (A-2) at 0.01-20 mass%, (B) condensed phosphate at 0.1-2 mass%, and (C) an anionic surfactant at 0.1-5 mass%; (D) two or three selected from among caryophyllene, germacrene, and viridiflorol; and (E) one or more selected from menthol and carvone. The content of component (D) is 0.01-50 parts by mass with respect to 100 parts by mass of component (E).

Description

[Technical Field]

[0001] The present invention relates to an oral composition that masks the unpleasant taste and irritation caused by metal salts and the like, has a natural, deep, and unique refreshing feeling (natural mint feeling), and is excellent in feel when used. [Background technology]

[0002] In recent years, oral care preparations with multiple functions have become popular, and compositions that combine multiple active ingredients have been developed. However, many of the ingredients used in oral compositions irritate the oral cavity or have an unpleasant taste, which impairs the oral composition's usability. Representative ingredients include potassium nitrate, an active ingredient with an anti-hypersensitivity effect and a desensitizing effect; aluminum lactate, a polyvalent metal salt with a dentinal tubule-blocking effect; other polyvalent metal salts such as copper salts, zinc salts, and tin salts; and condensed phosphates, which are known to have an anti-staining effect on teeth. However, these ingredients have a metallic taste and are irritating. Furthermore, some anionic surfactants, which are commonly incorporated into oral compositions to enhance foaming, have a bitter taste and are irritating. Therefore, when any of the above ingredients is incorporated, in addition to the unpleasant taste inherent to the ingredient itself, irritation to the oral cavity is significantly increased, resulting in a poor usability. Incorporation of these ingredients simultaneously tends to further worsen the usability. Regarding masking unpleasant tastes, Patent Document 1 (JP 2006-96696 A) proposes improving taste by incorporating a relatively large amount of polyhydric alcohol into a specific combination of potassium nitrate and water-soluble polyphosphate salts. Patent Document 2 (JP 2017-210454 A) proposes combining potassium salt and / or aluminum salt with specific flavoring ingredients such as sodium chloride and allylphenoxyacetate to suppress metallic taste and irritation and provide a refreshing feeling after use. Patent Document 3 (JP 2017-141178 A) proposes combining potassium nitrate and / or aluminum lactate with α-olefin sulfonate and sucralose to provide excellent hypersensitivity suppression and foaming properties, while also improving overall taste. Patent Document 4 (JP 2003-137755 A) proposes a technology for suppressing metallic taste using menthol derivatives.

[0003] On the other hand, oral care preparations that impart a cooling sensation are preferred, and oral compositions often contain mint flavors containing menthol or carvone as fragrance ingredients. As mint flavors, for example, in addition to artificial mint flavors, natural essential oils such as peppermint oil and peppermint oil, which contain menthol as the main component, and spearmint oil, which contains carvone as the main component, may also be used, and these mint flavors are effective in improving flavor. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2006-96696 [Patent Document 2] Japanese Patent Application Laid-Open No. 2017-210454 [Patent Document 3] Japanese Patent Application Laid-Open No. 2017-141178 [Patent Document 4] Japanese Patent Application Laid-Open No. 2003-137755 Summary of the Invention [Problem to be solved by the invention]

[0005] However, although there have been technologies for improving the usability of oral compositions by masking the unpleasant taste or irritation caused by metal salts, condensed phosphates, or anionic surfactants with specific ingredients, there is still room for improvement in the mint flavor of oral compositions that contain these ingredients as well as mint flavors, and improving the usability has been an issue.

[0006] The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition that masks and suppresses the unpleasant taste and irritation caused by metal salts and the like, has a natural, deep, and unique refreshing feeling, and is excellent in feel when used. [Means for solving the problem]

[0007] As a result of intensive research conducted by the present inventors to achieve the above-mentioned object, they have found that by blending a specific amount of a specific component, such as a specific metal salt, which has an unpleasant taste or irritation, with a mint flavor containing a combination of two or more components selected from caryophyllene, germacrene, and viridiflorol in a specific ratio, the unpleasant taste and irritation caused by the specific component, such as the specific metal salt, are masked, the bitterness and irritation associated therewith are suppressed and improved, and the refreshing feeling of the mint flavor is not impaired but is prominently expressed, imparting a natural, deep, and unique refreshing feeling (natural mint feeling), and providing an excellent usability. That is, in the present invention, the following components (A) to (C) are blended: (A) 0.01 to 20 mass% of one or more selected from potassium salts (A-1) and water-soluble polyvalent metal salts (A-2); (B) 0.1 to 2% by mass of a condensed phosphate, and (C) Anionic surfactant 0.1 to 5% by mass The present inventors have discovered that by blending two or three compounds selected from (D) caryophyllene, germacrene, and viridiflorol and one or more compounds selected from (E) menthol and carvone in an oral composition containing one or more compounds selected from the group consisting of (A), (B), and (C), the unpleasant taste and irritation caused by the compounds (A), (B), and (C) are masked and suppressed, and a natural, deep, and unique refreshing feeling is imparted, resulting in an excellent usability, and have completed the present invention.

[0008] In the present invention, by using two or three specific substances in combination as component (D) and combining this combination with component (E) in a specific ratio, even an oral composition containing the three components (A), (B), and (C) can be formulated with the unpleasant taste and irritation suppressed, and a natural, deep, and unique refreshing sensation can be imparted (a natural, deep, and unique refreshing sensation that differs from a refreshing sensation with a sharp fragrance and no flavor or thickness; hereinafter, this may be abbreviated as natural refreshing sensation), resulting in a significantly superior usability. As shown in the comparative examples described below, even if a mint flavor was blended, if there was only one substance in component (D), the lack of bitterness and irritation during use and the natural cooling sensation were inferior (Comparative Examples 3 to 5). Furthermore, even if two or three substances were blended as component (D), if the ratio of components (D) to (E) was inappropriate, the natural cooling sensation was inferior (Comparative Examples 1 and 2). Comparative Example 2, in which the ratio was too low, also exhibited poor lack of bitterness and irritation during use. In contrast, the oral compositions of the present invention shown in the examples were excellent in both lack of bitterness and irritation during use and the natural cooling sensation, suppressed unpleasant tastes and irritation, and provided a natural, deep cooling sensation.

[0009] Therefore, the present invention provides the following oral compositions. [1] Components (A) to (C) shown below (A) 0.01 to 20 mass% of one or more selected from potassium salts (A-1) and water-soluble polyvalent metal salts (A-2); (B) 0.1 to 2% by mass of a condensed phosphate, and (C) Anionic surfactant 0.1 to 5% by mass One or more ingredients selected from the above, (D) two or three selected from caryophyllene, germacrene, and viridiflorol; (E) one or more selected from menthol and carvone and wherein the content of component (D) is 0.01 to 50 parts by mass per 100 parts by mass of component (E). [2] The oral composition according to [1], wherein the potassium salt (A-1) is selected from potassium nitrate, potassium citrate, potassium chloride and potassium sulfate. [3] The oral composition according to [1] or [2], wherein the water-soluble polyvalent metal salt (A-2) is selected from the group consisting of copper salts, zinc salts, aluminum salts and tin salts. [4] The oral composition according to any one of [1] to [3], wherein the water-soluble polyvalent metal salt (A-2) is selected from the group consisting of chlorides, citrates, lactates, gluconates, malonates, malates, and sulfates of polyvalent metals. [5] (B) The oral composition according to any one of [1] to [4], wherein the condensed phosphate is at least one selected from tripolyphosphates, pyrophosphates, and hexametaphosphates. [6] (C) The oral composition according to any one of [1] to [5], wherein the anionic surfactant is one or more selected from acyltaurine salts, acylamino acid salts, α-olefin sulfonates, alkyl sulfoacetates, alkenyl sulfoacetates, polyoxyethylene alkyl ether phosphates, and polyoxyethylene alkenyl ether phosphates. [7] The oral composition according to any one of [1] to [6], which contains 0.0002 to 0.3 mass % of component (D). [8] The oral composition according to any one of [1] to [7], which is a dentifrice, a mouthwash, a mouth spray, a topical agent, or a patch. [Effects of the Invention]

[0010] According to the present invention, an oral composition can be provided that masks and improves the unpleasant taste and irritation caused by components (A), (B), and (C), and has a natural, deep, and unique refreshing feeling and excellent usability. The oral composition of the present invention can also provide the medicinal effects of components (A), (B), and (C) while providing an excellent usability accompanied by a unique minty refreshing feeling, and is effective for preventing or suppressing oral diseases such as tooth sensitivity and periodontal disease. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention will be described in further detail below. The oral composition of the present invention comprises the following components (A) to (C): (A) one or more selected from potassium salts (A-1) and water-soluble polyvalent metal salts (A-2); (B) condensed phosphates, and (C) Anionic surfactants (D) one or more components selected from caryophyllene, germacrene, and viridiflorol; and (E) one or more components selected from menthol and carvone.

[0012] The component (A) is at least one selected from potassium salts (A-1) and water-soluble polyvalent metal salts (A-2), with potassium salts (A-1) being particularly preferred. The amount of component (A) blended is adjusted depending on the type of substance used, but can be 0.01 to 20% (mass %, the same applies below) of the total composition.

[0013] Potassium salt (A-1) has a desensitizing effect and is effective in preventing hypersensitivity. Examples of potassium salts include potassium nitrate, potassium citrate, potassium chloride, potassium sulfate, etc., which can be used alone or in combination of two or more. Of these, potassium nitrate is preferred. As potassium nitrate, for example, a commercially available product manufactured by Otsuka Chemical Co., Ltd. can be used.

[0014] The amount of potassium salt blended is preferably 0.1 to 15% of the total composition, more preferably 0.5 to 10%, and even more preferably 1 to 8%. If the blending amount exceeds 15%, the unpleasant taste associated with the metallic taste of the salt itself becomes strongly perceived as bitterness or irritation, which cannot be masked, resulting in a poor usability. The higher the blending amount, the greater the hypersensitivity suppression effect. However, even if the blending amount exceeds 15%, an increase in the hypersensitivity suppression effect commensurate with the increase in blending amount cannot be expected, and instead a stronger metallic taste is produced.

[0015] The water-soluble polyvalent metal salt (A-2) is preferably an aluminum salt, a copper salt, a zinc salt, or a tin salt, and examples of the salt include citrates, lactates, gluconates, malonates, malates, sulfates, and chlorides of polyvalent metals. These may be used alone or in combination of two or more. The water-soluble polyvalent metal salts have effects according to the type of substance, such as the effect of providing a firming feeling to the gums and the effect of suppressing bad breath. The total amount of component (A-2) is preferably 0.01 to 5%, more preferably 0.03 to 3%, based on the total amount of the composition.

[0016] Examples of aluminum salts include aluminum lactate, aluminum gluconate, aluminum malonate, and aluminum malate. The amount of aluminum salt blended is preferably 0.01 to 5%, more preferably 0.03 to 3%, of the total composition, which provides sufficient dentinal tubule sealing effect and particularly effective suppression of metallic taste. Aluminum potassium sulfate can also be used. Aluminum potassium sulfate has the effect of providing a feeling of firming the gums. From the viewpoint of providing a feeling of firming the gums and suppressing a metallic taste, the amount of aluminum potassium sulfate added is preferably 0.01 to 5%, more preferably 0.03 to 3%, of the total composition. Examples of copper salts include water-soluble copper salts such as copper gluconate, copper citrate, and copper sulfate; examples of zinc salts include zinc citrate, zinc lactate, zinc gluconate, and zinc chloride; and examples of tin salts include tin citrate, tin lactate, tin gluconate, and tin chloride. The amount of each of the copper salt, zinc salt, and tin salt is preferably 0.01 to 3%, more preferably 0.03 to 2%, of the total composition. Within this range, the effect of suppressing bad breath and the feeling of firming the gums can be sufficiently obtained, and the metallic taste is particularly well suppressed.

[0017] (B) Condensed phosphate has the effect of inhibiting stain adhesion. Examples of condensed phosphates include linear polyphosphates such as pyrophosphate, tripolyphosphate, and tetrapolyphosphate, and cyclic polyphosphates such as trimetaphosphate, tetrametaphosphate, and hexametaphosphate, and examples of salts include sodium salts and potassium salts. These can be used alone or in combination of two or more. Among these, pyrophosphate, tripolyphosphate, and hexametaphosphate are preferred, and sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, potassium tripolyphosphate, sodium hexametaphosphate, and potassium hexametaphosphate are particularly preferred. As the condensed phosphate, commercially available products such as sodium pyrophosphate and sodium tripolyphosphate manufactured by Taihei Chemical Industry Co., Ltd. can be used.

[0018] The blending amount of (B) condensed phosphate is preferably 0.1 to 2% of the total composition, more preferably 0.2 to 2%, and even more preferably 0.5 to 1.2%. The higher the blending amount, the more sufficient the stain adhesion inhibitory effect is exerted, but if the blending amount exceeds 2%, the irritation itself becomes too strong and masking becomes impossible, resulting in a poor usability.

[0019] (C) Anionic surfactants are surfactants that are effective in ensuring foaming. Examples of anionic surfactants include acylamino acid salts, acyltaurine salts, α-olefin sulfonates, alkyl sulfoacetates, alkenyl sulfoacetates, polyoxyethylene alkyl ether phosphates, and polyoxyethylene alkenyl ether phosphates, and these can be used alone or in combination of two or more. The alkyl group, alkenyl group, and acyl group of the above substances preferably each have 10 to 18 carbon atoms. Examples of salts include alkali metal salts and ammonium salts, with sodium salts and potassium salts being preferred. Specific examples include lauroyl glutamate, N-lauroyl sarcosine salt, lauroyl methyl taurine salt, tetradecene sulfonate, lauryl sulfoacetate, polyoxyethylene oleyl ether phosphate, etc., but are not limited to these.

[0020] The amount of the anionic surfactant (C) blended is preferably 0.1 to 5% of the total composition, more preferably 0.1 to 2%, and particularly preferably 0.1 to 0.5%. If the blending amount is 0.1% or more, sufficient foaming can be obtained, but if it exceeds 5%, the bitterness and irritation of the surfactant itself become too strong and cannot be masked, resulting in a poor usability.

[0021] The above components (A), (B), and (C) can be blended singly or in combination of two or more components, and three components can also be blended. In the present invention, even when the three components (A), (B), and (C) are blended simultaneously, the bitterness and irritation are masked and improved, and an excellent feeling when used can be achieved. Component (A) may overlap with component (B) or (C), in which case a substance other than component (B) or (C) may be used as component (A).

[0022] The component (D) is two or three selected from caryophyllene, germacrene, and viridiflorol, and it is preferable to use a combination of three. Ingredient (D) masks and suppresses the bitterness and irritation caused by ingredients (A), (B), and (C), while also imparting a natural, deep, and unique refreshing sensation (natural mint sensation). Examples of caryophyllene include β-caryophyllene. Component (D) can be formulated as a single fragrance material such as caryophyllene, germacrene, or viridiflorol, but can also be formulated as an extract of essential oils or the like containing each substance. The component (D) may be a chemically synthesized product, a product obtained by extraction from a natural product (an extract from a natural product), a combination of a product obtained from a natural product and a product obtained by chemical synthesis, or a commercially available product.

[0023] The component (D) is preferably blended in the amount ratio shown below. If it is within the range shown below, bitterness and irritation are further suppressed and a more natural cooling sensation can be imparted. When caryophyllene and germacrene are blended, the mass ratio of caryophyllene:germacrene is preferably 1:0.2 to 1:2.5, and more preferably 1:1 to 1:2.5. When caryophyllene and viridiflorol are blended, the mass ratio of caryophyllene:viridiflorol is preferably 1:0.3 to 1:5, and more preferably 1:1 to 1:5. When caryophyllene, germacrene, and viridiflorol are blended, the mass ratio of caryophyllene:germacrene:viridiflorol is preferably 1:(0.2-2.5):(0.3-5), and more preferably 1:(1-2.5):(1-5).

[0024] Specific examples of such commercially available caryophyllene (D) components that can be used include caryophyllene-BE (manufactured by Inoue Perfumery Manufacturing Co., Ltd.), germacrene (manufactured by Toronto Research), and viridiflorol (manufactured by Toronto Research). Specific examples of extracts of essential oils and the like that can be used include peppermint oil containing caryophyllene, germacrene, and viridiflorol, Japanese mint oil containing caryophyllene and germacrene, spearmint oil containing caryophyllene and viridiflorol, and artificial mint oil containing caryophyllene, germacrene, and viridiflorol. These can be extracted from Mentha plants of the Lamiaceae family by known methods, or commercially available products can be used.

[0025] Furthermore, as the component (D), an essential oil (essential oil containing component (D)) produced by the following method can be preferably used as an extract from a natural product (see Patent Application No. 2020-87507). The raw material is a plant of the genus Mentha of the family Lamiaceae. Examples of the plant of the genus Mentha of the family Lamiaceae include peppermint, mint, and spearmint, and essential oils obtained by known distillation are preferably used. The above-mentioned oil (crude essential oil) derived from a plant of the genus Mentha of the Lamiaceae family is subjected to precision distillation under conditions of a pressure of 0.00001 to 0.05 bar, preferably 0.002 to 0.04 bar, more preferably 0.004 to 0.03 bar, and 40 to 250°C, preferably 60 to 180°C, more preferably 80 to 140°C, to recover 75 to 97%, preferably 92 to 96%, of the total amount of oil derived from a plant of the genus Mentha of the Lamiaceae family as volatile fraction A, and obtain a distillation residue consisting of 3 to 25%, preferably 4 to 8%, of the total amount of oil derived from a plant of the genus Mentha of the Lamiaceae family. The precision distillation is preferably carried out under conditions of a pressure of 0.002 to 0.04 bar and 60 to 180°C, more preferably a pressure of 0.004 to 0.03 bar and 80 to 140°C, and by such conditions, component (D) can be concentrated in the distillation residue. Next, the distillation residue (non-volatile fraction A) is subjected to thin-film distillation to obtain a volatile fraction (first volatile fraction) consisting of volatile fraction B, which accounts for 5 to 50%, preferably 10 to 30%, of the total amount of the distillation residue. The essential oil thus obtained can be used as an essential oil containing component (D). The distillation conditions for obtaining the volatile fraction (first volatile fraction) are preferably 90 to 180°C and a pressure of 0.00001 to 0.01 bar, and more preferably 140 to 160°C and a pressure of 0.002 to 0.008 bar. The second volatile fraction, which is obtained by further thin-film distillation of volatile fraction B and which comprises 50-95%, preferably 60-95%, and more preferably 60-90% of the total amount of volatile fraction B, is a more preferred essential oil containing component (D). The distillation conditions for obtaining the second volatile fraction are preferably 90-180°C and a pressure of 0.00001-0.01 bar, and more preferably 140-160°C and a pressure of 0.002-0.008 bar. The second volatile fraction is particularly preferred in terms of achieving the effects of the present invention, since it removes more components such as resin that contribute to unpleasant flavors than the first volatile fraction. The essential oil containing component (D) obtained in this manner contains a total of 15 to 50%, preferably 20 to 40%, and more preferably 30 to 40% of two or more substances selected from β-caryophyllene, germacrene D, and viridiflorol, and is suitable as component (D).

[0026] The amount of component (D) is adjusted so that the ratio to component (E) is within an appropriate range, and is preferably 0.0002 to 0.3%, more preferably 0.0004 to 0.3%, of the total composition. When the amount is 0.0002% or more, a natural, deep, refreshing sensation is sufficiently obtained, and when it is 0.3% or less, the taste derived from component (D) has little effect on the flavor.

[0027] Component (E) is one or two selected from menthol and carvone, which are agents that impart a cooling sensation and are also the main components of mint flavors. Component (E) can also be formulated as an essential oil containing menthol (L-menthol) and / or carvone. Specifically, peppermint oil, spearmint oil, Japanese peppermint oil, or artificial mint oil obtained by a known method can be used. Commercially available products such as L-menthol (manufactured by Takasago International Corporation) and carvone (manufactured by Shiono Koryo Co., Ltd.) can also be used.

[0028] The blending amount of component (E) is preferably 0.05 to 2% of the total composition, more preferably 0.1 to 1.5%. When the blending amount is 0.05% or more, a natural and deep refreshing feeling is sufficiently obtained, and when the blending amount is 2% or less, the irritation caused by component (E) and the poor feeling in use are not caused.

[0029] In the present invention, when essential oils such as peppermint oil, spearmint oil, Japanese peppermint oil, artificial mint oil, and essential oils derived from natural sources are blended as components (D) and (E), each essential oil may contain components (D) and (E). In such cases, the amounts of each component in each essential oil are added together and treated as the total amount of component (D) and the total amount of component (E).

[0030] The ratio (quantitative ratio) of component (D) to component (E) is 0.01 to 50 parts by mass, preferably 0.05 to 10 parts by mass, more preferably 0.1 to 2.5 parts by mass, and most preferably 0.4 to 2.5 parts by mass, per 100 parts by mass of component (E). Within this quantitative ratio range, the bitterness and irritation from components (A), (B), and (C) are masked and improved, and a natural, deep, refreshing sensation is achieved, resulting in a highly palatable, excellent feel when used. If the amount of component (D) is less than 0.01 part by mass per 100 parts by mass of component (E), the lack of bitterness and irritation is inferior, while if it exceeds 50 parts by mass, the natural refreshing sensation is inferior.

[0031] The oral composition of the present invention can be used as a dentifrice, mouthwash, mouth spray, liniment, patch, etc. Among these, dentifrice and mouthwash are preferred, with dentifrice being particularly preferred, in terms of the manifestation of the effects of the present invention. The composition can be in the form of a liquid, liquid-like, paste-like, etc., and dentifrice is preferably prepared as a toothpaste, liquid dentifrice, liquid dentifrice, lubricant dentifrice, etc., and is particularly preferably prepared as a toothpaste. In this case, in addition to the above-mentioned components, other optional components depending on the application, dosage form, etc., can be appropriately blended within a range that does not impair the effects of the present invention. Specifically, toothpaste may contain surfactants, abrasives, thickeners, binders, and, if necessary, sweeteners, preservatives, colorants, flavorings, various active ingredients, etc.

[0032] In addition to the above components, nonionic surfactants and amphoteric surfactants may be added as surfactants. Examples of nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, lauric acid mono- or diethanolamide, and sorbitan fatty acid esters. Among these, polyoxyethylene hydrogenated castor oil (particularly those with an added mole number of ethylene oxide of 10 to 30) and polyoxyethylene alkyl ethers (particularly those with an added mole number of ethylene oxide of 3 to 5 and a carbon chain length of the alkyl moiety of 16 to 18) are particularly suitable from the viewpoint of solubilization. Examples of amphoteric surfactants include N-alkyldiaminoethylglycines such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1-hydroxyethylimidazoline betaine sodium. The amount of these surfactants to be blended is preferably 0.1 to 5%, particularly preferably 0.1 to 4%, of the total composition.

[0033] Examples of abrasives include silica-based abrasives such as crystalline silica, amorphous silica, silica gel, and aluminosilicate, zeolite, calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasives. The amount of abrasive blended is usually 5 to 70%, and particularly 10 to 50%, of the total composition.

[0034] Examples of thickeners include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as propylene glycol, butylene glycol, glycerin, and polyethylene glycol. The amount of thickener blended is usually 0 to 70%, particularly 3 to 50%, of the total composition. The binder may be an organic or inorganic binder. Examples include organic binders such as xanthan gum and sodium carboxymethyl cellulose, and inorganic binders such as thickening silica and thickening aluminum silica. The amount of binder blended is usually 0.1 to 10%, particularly 0.1 to 8%, of the total composition.

[0035] Sweeteners include saccharin sodium and the like. Examples of preservatives include benzoates such as sodium benzoate, and parahydroxybenzoates such as methylparaben, ethylparaben, and butylparaben. Examples of the coloring matter include brilliant blue, which is a food coloring matter, tartrazine, and titanium oxide, which is a pigment.

[0036] Optional fragrances include, for example, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, yuzu oil, lavender oil, rosemary oil, laurel oil, perilla oil, chamomile oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, patchouli oil, paracles oil, iris concrete, rose absolute, orange fragrance, Natural fragrances such as war absolute, vanilla absolute, lavender absolute, patchouli absolute, and processed fragrances (front end cut, tail end cut, fractional distillation, liquid-liquid extraction, essence, powdered fragrance, etc.) of these natural fragrances, limonene, pinene, butanol, isoamyl alcohol, hexenol, linalool, anethole, thymol, eugenol, menthone, pulegone, fenchone, cineole, hexanal, octanal, anisaldehyde, cinnamic aldehyde, ethyl acetate, ethyl butyrate It is possible to use in combination with known flavoring materials used in oral compositions, such as single flavorings such as benzoyl alcohol, benzophenone, benzoyl benzoate ... The amount of these fragrance materials to be added is not particularly limited, but it is preferable to use 0.000001 to 1% in the composition.The fragrance using the above-mentioned fragrance material is preferably used in an amount of 0.1 to 2.0% in the composition. When the optional fragrance contains the components (D) and / or (E), it can be used within the range of the blending amount of the components (D) and / or (E) described above.

[0037] The active ingredient (medicinal ingredient) may be a bactericidal or antibacterial agent such as chlorhexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzethonium chloride, or benzalkonium chloride; an anti-tartar agent such as ethanehydroxydiphosphonate; an enzyme such as tranexamic acid, glycyrrhizic acid or a salt thereof, dextranase, mutanase, or lysozyme chloride; a vitamin such as ascorbic acid or tocopherol acetate; an astringent such as sodium chloride; or a fluoride such as sodium fluoride or sodium monofluorophosphate, and the like, which may be used within a pharmaceutically acceptable range. [Example]

[0038] The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[0039] [Examples and Comparative Examples] Oral compositions (dentifrices) having the compositions shown in Tables 1 to 6 were prepared by conventional methods, and the sensation of use was evaluated by the following method. The results are also shown in the tables.

[0040] How to evaluate usability Ten subject monitors applied the oral composition (dentifrice) to a toothbrush, brushed their teeth in the usual way, and evaluated the sensation of use (lack of bitterness and irritation during use, natural refreshing sensation) according to the following evaluation criteria. The scores of the 10 subjects were averaged and judged according to the following criteria. Here, the natural refreshing sensation is different from the refreshing sensation of a sharp fragrance without a rich flavor or thickness, and refers to a unique refreshing sensation that is natural and deep. (i) No bitterness or irritation during use Evaluation criteria 4 points: No bitterness or irritation felt in the mouth. 3 points: Slight bitterness and irritation in the mouth. 2 points: Bitterness and irritation felt in the mouth. 1 point: Very bitter and irritating taste in the mouth. Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points (ii) Natural cooling sensation Evaluation criteria 4 points: A very natural, deep and refreshing feeling. 3 points: A natural, deep, refreshing feeling. 2 points: A natural, deep, slightly refreshing sensation. 1 point: Doesn't give a natural, deep, refreshing feeling. Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

[0041] Details of the raw materials used are shown below. (D) Component Caryophyllene (D1): Caryophyllene-BE (manufactured by Inoue Perfumery Manufacturing Co., Ltd.) Germacrene (D2): Germacrene D (Toronto Research) Viridiflorol (D3): Viridiflorol (manufactured by Toronto Research) Component (E) is sometimes blended as flavoring 1 (mint flavor), but some flavorings contain component (D). The following peppermint oil, spearmint oil, Japanese peppermint oil, and artificial mint oil were used in flavoring 1. Peppermint oil (ADM): (D) component 3.4% (caryophyllene (D1) 2%, germacrene ( Contains D2) 1.2%, viridiflorol (D3) 0.2%) (E) Contains 42% menthol Japanese seed oil (manufactured by Toyo Minari Kogyo Co., Ltd.): (D) component 1.03% (caryophyllene (D1) 1%, germacrene (D2)0.03%) Contains (E) Contains 42% menthol Spearmint oil (ADM): (D) component 0.8% (caryophyllene (D1) 0.5%, germanium chloride Contains (D2) 0.3%) (E) Contains 60% carvone Artificial mint oil (Takasago International Corporation): (D) component 3.2% (caryophyllene (D1) 2%, germacrene ( Contains D2) 1% and viridiflorol (D3) 0.2%) (E) Contains 42% menthol Fragrance 2 has the following composition (fragrance ingredients other than mint-based). Fragrance 2 composition: Anethole 10 Clove oil 0.4 2 tablespoons coriander oil Thyme oil 0.4 Black tea flavor 10 1 sachet of lavender oil 1 jasmine oil Fruit Flavor 1 Ethanol 74.2 Total 100%

[0042] [Table 1] *: The total amount of ingredient (D), including the amount of ingredient (D) contained in fragrance 1 ((D1) + (D2) + (D3)). ** Caryophyllene (D1), germacrene (D2), and viridiflorol (D3) contained in fragrance 1 were also added together and calculated as (D1):(D2):(D3) (mass ratio). ***: Component (E) was blended as fragrance 1.

[0043] [Table 2]

[0044] [Table 3]

[0045] [Table 4]

[0046] [Table 5]

[0047] [Table 6]

[0048] Free Answer Example 1: No bitterness or irritation, with a natural, deep, and unique refreshing sensation can be done. Comparative Example 1: There is no bitterness or irritation, but the smell of the individual ingredients is strong and somewhat refreshing. It lacks the natural cooling sensation. Comparative Example 2: Bitterness and irritation are slightly reduced. The natural cooling sensation is somewhat lacking. do. Comparative Example 3: Bitter and stimulating, with a sharp, refreshing taste without any thick flavor. can be done. Comparative Example 4: Bitter and stimulating, with a sharp, refreshing taste without any thick flavor. can be done. Comparative Example 5: Bitter and stimulating, with a sharp, refreshing taste without any thick flavor. can be done.

[0049] [Example 32] (A) Potassium nitrate 5 (B) Sodium tripolyphosphate 1 (C) Sodium lauroyl methyl taurate 0.4 (D) Peppermint essential oil C (*) 0.006 (E) Menthol 0.5 Xanthan gum 1.6 Coconut oil fatty acid amidopropyl betaine 0.6 Mica Titanium 0.7 Sorbitol 28 Propylene Glycol 4 Abrasive Silica 10 Thickening Silica 5 Sodium fluoride 0.32 Sodium saccharin 0.17 Methyl parahydroxybenzoate 0.18 Fragrance 2 0.5 Purified water remainder Total 100% (*); Peppermint essential oil C 500 kg of peppermint oil (manufactured by ADM) was used as crude oil and was distilled under reduced pressure (temperature 80-140°C, pressure 0.01-0.02 bar) to obtain a volatile fraction A and 28.9 kg of a non-volatile fraction A. Next, the obtained non-volatile fraction A was thin-film distilled (heat medium temperature 150°C, pressure 0.0040 bar) to obtain a volatile fraction B and 23.1 kg of a non-volatile fraction B. The obtained volatile fraction B was further thin-film distilled (heat medium temperature 150°C, pressure 0.0040 bar) to obtain 4.6 kg of a volatile fraction C. The amount of component (D) in the obtained volatile fraction C (peppermint essential oil C) (content of components (D1), (D2), and (D3)) was 7% β-caryophyllene, 13% germacrene, and 17% viridiflorol. Amount of component (D) in the composition (D1)0.00042%, (D2)0.00078%, (D3)0.0010% (D) Total amount of ingredients ((D1) + (D2) + (D3)); 0.0022 (D1):(D2):(D3)(mass ratio);1:1.85:2.38 Total amount (parts by mass) of component (D) per 100 parts by mass of component (E): 0.44 The dentifrice of Example 32 was prepared in the same manner as in the above examples and evaluated. No bitterness or irritation during use ◎ Natural cooling sensation It was.

[0050] [Example 33] Dentifrice (A) Copper gluconate 0.1 (B) Sodium tripolyphosphate 1 (C) Sodium lauroyl methyl taurate 1 (D) Caryophyllene (D1) 0.000426 (D) Germacrene (D2) 0.000786 (D) Viridiflorol (D3) 0.001000 (E) Menthol 0.53 Abrasive Silica 12 Thickening Silica 3 Glycerin (85%) 40 Propylene Glycol 3 Sodium citrate 0.2 Sodium monofluorophosphate 0.7 Sodium carboxymethylcellulose 1 Xanthan gum 0.3 Sodium saccharin 0.1 Titanium dioxide 0.5 Fragrance 0.5 Purified water remainder Total 100% (D) Total amount of components ((D1) + (D2) + (D3)); 0.002212 (D1):(D2):(D3)(mass ratio);1:1.85:2.35 Total amount (parts by mass) of component (D) per 100 parts by mass of component (E): 0.41736

[0051] [Example 34] Dentifrice (A) Potassium nitrate 5 (A) Stannous fluoride 0.4 (B) Sodium hexametaphosphate 1.0 (C) Sodium lauryl sulfate 1.2 (C) Sodium tetradecene sulfonate 0.3 (D) Peppermint essential oil C (*) 0.006 (E) Menthol 0.5 Abrasive Silica 15 Thickening Silica 3 Sorbitol 35 Propylene Glycol 3 Sodium citrate 0.2 Sodium monofluorophosphate 0.38 Sodium carboxymethylcellulose 1 Xanthan gum 0.3 Sodium saccharin 0.1 Titanium dioxide 0.5 Sodium hydroxide 0.2 Fragrance 0.5 Purified water remainder Total 100% Amount of component (D) in the composition (D1)0.00042%, (D2)0.00078%, (D3)0.0010% (D) Total amount of ingredients ((D1) + (D2) + (D3)); 0.0022 (D1):(D2):(D3)(mass ratio);1:1.85:2.38 Total amount (parts by mass) of component (D) per 100 parts by mass of component (E): 0.44

[0052] [Example 35] Dentifrice (A) Potassium nitrate 5 (A) Aluminum lactate 2 (B) Potassium pyrophosphate 1.2 (C) Sodium lauryl sulfate 1.2 (C) Sodium lauroyl glutamate 0.3 (D) Peppermint essential oil C (*) 0.006 (E) Menthol 0.5 Abrasive Silica 16 Thickening Silica 3 Sorbitol 20 Glycerin (80%) 10 Propylene Glycol 3 Sodium monofluorophosphate 1.1 Sodium carboxymethylcellulose 1 Xanthan gum 0.3 Sodium saccharin 0.1 Titanium dioxide 0.5 Sodium hydroxide 0.2 Fragrance 0.5 Purified water remainder Total 100% Amount of component (D) in the composition (D1)0.00042%, (D2)0.00078%, (D3)0.0010% (D) Total amount of ingredients ((D1) + (D2) + (D3)); 0.0022 (D1):(D2):(D3)(mass ratio);1:1.85:2.38 Total amount (parts by mass) of component (D) per 100 parts by mass of component (E): 0.44

Claims

1. (A) 1 to 8 mass% potassium nitrate; Components (B) and (C) shown below (B) 0.1 to 2% by mass of a condensed phosphate; and (C) Anionic surfactant: 0.1 to 5% by mass One or more components selected from (D) 0.000885 to 0.012752 mass% of caryophyllene, germacrene, and viridiflorol; (E) one or more selected from menthol and carvone; The oral composition contains the above, and the content of the (D) component is 0.16694 to 2.40604 parts by mass per 100 parts by mass of the (E) component.

2. An oral composition as described in claim 1, containing the above components (A), (B) and (C).

3. 3. The oral composition according to claim 1, wherein the condensed phosphate (B) is at least one selected from the group consisting of tripolyphosphates, pyrophosphates, and hexametaphosphates.

4. The oral composition according to any one of claims 1 to 3, wherein (C) the anionic surfactant is one or more selected from acyltaurine salts, acylamino acid salts, α-olefin sulfonates, alkylsulfoacetates, alkenylsulfoacetates, polyoxyethylene alkyl ether phosphates, and polyoxyethylene alkenyl ether phosphates.

5. The oral composition according to any one of claims 1 to 4, which is a dentifrice, a mouthwash, a mouth spray, a liniment, or a patch.

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