Sebum odor suppressant composition

Abstract

To provide a sebum odor inhibitor composition that can effectively inhibit middle-aged fat odors (particularly, a sebum odor).SOLUTION: A sebum odor inhibitor composition contains the following components (A) and (B). Component (A): at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethyl aminomethane and 2-amino-2-methyl-1,3-propanediol. Component (B): sodium lauroamphoacetate.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a sebum odor suppressant composition containing at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol, and sodium lauroamphoacetate. [Background technology]

[0002] In recent years, awareness of human odors has increased. These odors include body odors emanating directly from the human body and odors emanating indirectly from clothing, shoes, and other sources. The greasy sweat odor (middle-aged greasy odor) characteristic of men aged 30 to 50 has particularly attracted attention as a type of body odor, and it has been revealed that the causative components are diacetyl and short- and medium-chain fatty acids. Among these, short- and medium-chain fatty acids are known to be closely related to sebum odor (an odor derived from sebum, which is generated by oxidation of sebum adhering to the surface of the skin, body hair, clothing, and the inside of shoes (insoles, etc.) through metabolism by resident bacteria, lipid peroxides, oxygen, ultraviolet rays, etc.).

[0003] Conventional body odor suppressants have been developed by incorporating antiperspirant or antibacterial ingredients, or by masking with fragrances or removing odorous substances by physical adsorption in order to suppress generated body odor. Furthermore, deodorants for eliminating body odor from a chemical perspective have been developed. For example, body odor suppressants containing polyhydroxyamine compounds are known that neutralize odorous components derived from aldehydes and isovaleric acid, thereby exerting a deodorizing effect from a chemical perspective (Patent Documents 1 to 3). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2006-320711 [Patent Document 2] Japanese Patent Application Laid-Open No. 2007-300963 [Patent Document 3] Japanese Patent Application Laid-Open No. 2015-224244 Summary of the Invention [Problem to be solved by the invention]

[0005] However, middle-aged oily odor is a particularly strong odor, and even the above-mentioned body odor suppressants are difficult to fully exert their effects, so there is a demand for the development of body odor suppressants with stronger effects.

[0006] Therefore, an object of the present invention is to provide a sebum odor inhibitor composition that can effectively suppress middle-aged oily odor (particularly sebum odor). [Means for solving the problem]

[0007] In view of the above circumstances, the present inventors have conducted extensive research to solve the problems, and as a result have found that a sebum odor inhibitor composition containing a specific polyhydroxyamine compound and sodium lauroamphoacetate effectively suppresses sebum odor, thereby completing the present invention.

[0008] That is, the present invention provides a sebum odor inhibitor composition containing at least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol (hereinafter sometimes referred to as "component (A)") and sodium lauroamphoacetate (hereinafter sometimes referred to as "component (B)").

[0009] The present invention also provides an external skin preparation containing the above-mentioned sebum odor suppressant composition.

[0010] The present invention also provides a spray-type deodorant containing the above sebum odor suppressant composition.

[0011] The present invention also provides a hair cleanser containing the above sebum odor inhibitor composition. [Effects of the Invention]

[0012] The sebum odor inhibitor composition of the present invention contains the above-mentioned components (A) and (B), and therefore can effectively suppress middle-aged oily odors (particularly sebum odor). [Brief explanation of the drawings]

[0013] [Figure 1] 10 shows the deodorizing effect on a used insole according to Example 3. [Figure 2] 1 shows the deodorizing (suppressing) effect on scalp odor according to Example 4. DETAILED DESCRIPTION OF THE INVENTION

[0014] [Sebum odor suppressant composition] The sebum odor inhibitor composition according to this embodiment is characterized by containing the following components (A) and (B). Component (A): At least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol Ingredient (B): Sodium lauroamphoacetate

[0015] Although the reason why the sebum odor inhibitor composition according to this embodiment is able to effectively suppress middle-aged oily odors (especially sebum odor) is unclear, it is believed to be closely related to the chemical interaction between the above-mentioned components (A) and (B) and the short- and medium-chain fatty acids, which are the causative substances of sebum odor. For example, it is believed that the short- and medium-chain fatty acids, components (A) and (B), respectively, undergo chemical interactions (e.g., chemical reactions, neutralization, etc.), converting the short- and medium-chain fatty acids into substances unrelated to sebum odor. It is also believed that component (B) acts as a catalyst in the chemical interaction between the short- and medium-chain fatty acids and component (A), thereby promoting the conversion of the short- and medium-chain fatty acids into substances unrelated to sebum odor. Through this mechanism, the sebum odor inhibitor composition according to this embodiment, which contains components (A) and (B) simultaneously, exhibits a synergistic deodorizing effect compared to when component (A) or component (B) is used alone.

[0016] While short-chain and medium-chain fatty acids are causative substances of sebum odor, it is known that medium-chain fatty acids in particular have a significant effect on sebum odor and have attracted attention as targets for deodorization (suppression of sebum odor). The sebum odor inhibitor composition according to this embodiment is particularly effective in that it has a significant deodorizing effect on medium-chain fatty acids. Here, it is difficult to uniformly define short-chain and medium-chain fatty acids, but for example, fatty acids with 6 or fewer carbon atoms, such as propionic acid and hexanoic acid, can be defined as short-chain fatty acids, and fatty acids with 7 or more carbon atoms, such as heptanoic acid, octanoic acid, and nonanoic acid, can be defined as medium-chain fatty acids.

[0017] The content of component (A) in the sebum odor suppressant composition is not particularly limited, but is preferably 0.001 to 30% by mass, more preferably 0.1 to 10% by mass. A content of 0.001% by mass or more tends to further improve the deodorizing effect on sebum odor. Furthermore, a content of 30% by mass or less is preferred from the viewpoints of formulation and stability.

[0018] The sebum odor suppressant composition of this embodiment contains sodium lauroamphoacetate. Sodium lauroamphoacetate significantly improves the sebum odor suppressing effect of the polyhydroxyamine compound by combining it with trishydroxymethylaminomethane and / or 2-amino-2-methyl-1,3-propanediol as the polyhydroxyamine compound.

[0019] The content of component (B) in the sebum odor suppressant composition is not particularly limited, but is preferably 0.00001 to 20% by mass, more preferably 0.0001 to 10% by mass. A content of 0.00001% by mass or more tends to further improve the deodorizing effect on sebum odor. Furthermore, a content of 20% by mass or less is preferred from the viewpoints of formulation and stability.

[0020] The mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) in the sebum odor suppressant composition is not particularly limited, but is preferably 0.001 or more, more preferably 0.01 or more, and even more preferably 0.1 or more. Also, it is preferably 100 or less, and more preferably 50 or less.

[0021] The sebum odor inhibitor composition according to this embodiment may contain water or a non-aqueous solvent (hereinafter sometimes referred to as component (C)) as a component other than components (A) and (B).

[0022] Examples of water include pure water and ultrapure water such as ion-exchanged water, ultrafiltered water, reverse osmosis water, and distilled water.

[0023] Examples of non-aqueous solvents include monohydric alcohols having 2 to 4 carbon atoms, such as ethanol and isopropanol; polyhydric alcohols having 2 to 12 carbon atoms, such as ethylene glycol, propylene glycol, glycerin, and sorbitol; ethers such as monoethyl or monobutyl ethers of ethylene glycol or propylene glycol, and monoethyl or monobutyl ethers of diethylene glycol or dipropylene glycol; aromatic compounds such as benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adducts of phenolic compounds, and aromatic sulfonates such as p-toluenesulfonate and m-xylenesulfonate; liquefied petroleum gas (LPG) such as propane, propylene, n-butane, and isobutane; liquefied gases such as liquefied carbon dioxide and liquefied nitrogen; compressed gases such as nitrogen, carbon dioxide, air, and nitrous oxide; isopentane, n-pentane, dimethyl ether (DME), and fluorohydrocarbons. Non-aqueous solvents may be used alone or in combination.

[0024] Furthermore, when the sebum odor suppressant composition according to this embodiment is used in a spray-type deodorant as described below, it is preferable that the component (C) contains at least one selected from liquefied petroleum gas (LPG), dimethyl ether (DME), isopentane, liquefied gas, and compressed gas, in order to ensure a suitable spray state.

[0025] The content of component (C) in the sebum odor inhibitor composition is not particularly limited, and can be the remainder excluding components (A), (B), and other components described below. The content of component (C) in the sebum odor inhibitor composition is, for example, preferably 80.0 mass% or more, more preferably 85.0 mass% or more, even more preferably 90.0 mass% or more, and particularly preferably 95 mass% or more. From the viewpoint of improving the feel when used, the content is preferably 99.9 mass% or less, more preferably 99.0 mass% or less.

[0026] The sebum odor inhibitor composition according to this embodiment may further contain components other than component (A), component (B), and component (C) (hereinafter referred to as "other components"). The other components are not particularly limited, but examples thereof include disinfectants, antiperspirants, surfactants, thickeners, moisturizers, deodorants, oil components, sequestering agents, preservatives, cooling agents, anti-inflammatory agents, plant extracts, and fragrances.

[0027] The disinfectant is not particularly limited, but examples thereof include benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, phenol, trichlorocarbanilide, chlorhexidine gluconate, isopropylmethylphenol, triclosan, triclocarban, piroctone olamine, zinc pyrithione, salicylic acid, sorbic acid, etc., with benzalkonium chloride and isopropylmethylphenol being preferred. The disinfectant may be used alone or in combination of two or more.

[0028] The antiperspirant is not particularly limited, but examples thereof include aluminum salts, zinc paraphenolsulfonate, etc. Examples of aluminum salts include aluminum chloride, aluminum sulfate, aluminum potassium sulfate (potassium alum), aluminum ammonium sulfate (ammonium alum), aluminum acetate, aluminum chlorohydrate, and aluminum allantoin chlorohydrate, etc. Among these, aluminum chlorohydrate, zinc paraphenolsulfonate, and aluminum potassium sulfate are preferred. One type of antiperspirant may be used alone, or two or more types may be used in combination.

[0029] The surfactant is not particularly limited, and examples thereof include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. The surfactants may be used alone or in combination of two or more.

[0030] The nonionic surfactant is not particularly limited, but examples thereof include polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyalkylene castor oil, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyalkylene glycerin fatty acid esters, sorbitan fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, sucrose fatty acid esters, and fatty acid alkylolamides. Examples of anionic surfactants include higher fatty acid soaps, alkyl sulfates, alkyl phosphates, polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl phenyl ether sulfates, alkyl ether phosphates, alkyl ether carboxylates, acylmethyl taurines, N-acyl-N-methyl-β-alanines, N-acylglycines, N-acylglutamates, polyoxyethylene alkyl carboxylates, alkyl phenyl ether sulfonates, alkyl sulfosuccinates and salts thereof, N-acylsarcosines and salts thereof, and polyoxyethylene coconut oil fatty acid monoethanolamide sulfate. Examples of cationic surfactants include amine salts such as alkylamine salts, fatty acid amidoamine salts, and ester-containing tertiary amine salts; alkyl quaternary ammonium salts such as monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium salts, trialkyl quaternary ammonium salts, and benzalkonium quaternary ammonium salts; cyclic quaternary ammonium salts such as alkylpyridinium salts; and benzethonium chloride. Examples of amphoteric surfactants include glycine-type amphoteric surfactants such as alkylglycine salts, carboxymethylglycine salts, and N-acylaminoethyl-N-2-hydroxyethylglycine salts; aminopropionic acid-type amphoteric surfactants such as alkylaminopropionates and alkyliminodipropionates; aminoacetic acid betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine; and sulfobetaine-type amphoteric surfactants such as alkylhydroxysulfobetaine.

[0031] Examples of thickeners include plant-derived polysaccharides such as guar gum, dextrin, starch, and pectin; animal-derived polysaccharides such as chitosan and hyaluronic acid; microbial-derived polysaccharides such as xanthan gum, cyclodextrin, pullulan, and hyaluronic acid; nonionic celluloses such as methylcellulose, ethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose; anionic celluloses such as carboxymethylcellulose; cationic celluloses such as O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride; cationic guar gums such as O-[2-hydroxy-3-(trimethylammonio)propyl]guar gum chloride; carboxyvinyl polymers; and acrylic acid / alkyl methacrylate copolymers. Thickeners may be used alone or in combination.

[0032] Examples of moisturizing agents include sorbitol, glycerin, etc. Examples of oil components include hydrocarbons, ester oils, silicones, etc. Examples of cooling agents include menthol such as l-menthol, menthol derivatives, and camphor, etc.

[0033] [External skin preparations] The topical skin preparation according to this embodiment is characterized by containing the above-mentioned sebum odor suppressant composition.

[0034] The topical skin preparation is not particularly limited, and examples thereof include topical skin preparations that impart a refreshing feeling to the applied skin, such as refreshing cosmetics; topical skin preparations that impart a moisturizing feeling to the applied skin, such as moisturizing cosmetics; topical skin preparations for antiperspirant use; topical skin preparations for fragrance use; topical skin preparations for disinfection; topical skin preparations for cleansing use, etc. The topical skin preparation may be, for example, any of cosmetics, quasi-drugs, pharmaceuticals, and miscellaneous goods.

[0035] The external cleansing agent for skin is not particularly limited, and examples thereof include hair cleansers such as shampoos and conditioners, body cleansers such as body soaps, and face cleansers such as cleansers and facial washes. Among these, hair cleansers and body cleansers are preferred, and hair cleansers are more preferred, since they contain a sebum odor suppressant composition that can effectively suppress middle-aged oily odors (particularly sebum odor).

[0036] The topical skin preparation can be used in various forms such as lotion, aerosol, non-aerosol spray, stick, roll-on, cream, gel, emulsion, sheet cosmetic, etc., and can be prepared by a commonly known method, such as mixing the above-mentioned components and stirring them using a known stirring device such as a disper mixer or paddle mixer to homogenize the components.

[0037] A sheet cosmetic is obtained by impregnating a sheet substrate with a topical skin preparation. This results in excellent usability when used to wipe the skin and excellent portability. The planar shape of the sheet is not particularly limited, but examples include quadrilaterals (e.g., squares, rectangles, etc.), polygons such as triangles, circles, ellipses, semicircles, crescents, barrels, drums, and character shapes, with quadrilaterals being preferred from the standpoints of productivity, usability, and packability. The sheet cosmetic may also be formed with slits, cutouts, uneven portions, etc. The surface area of ​​one side of the sheet of the sheet cosmetic is not particularly limited, but from the standpoints of usability, portability, packability, etc., it is preferred to have a surface area of ​​100 to 500 cm. 2 is preferred.

[0038] The sheet cosmetic can be produced by impregnating a sheet substrate with the topical skin preparation according to this embodiment. The method for impregnating the sheet substrate with the topical skin preparation is not particularly limited, and examples include a method of injecting the topical skin preparation into a folded sheet substrate to impregnate it, a method of spraying the topical skin preparation onto the sheet substrate, a method of impregnating the sheet substrate with the topical skin preparation using a printing method, and a method of immersing the sheet substrate in the topical skin preparation.

[0039] The material of the sheet substrate is not particularly limited as long as it can be impregnated with the above-mentioned topical skin preparation, and sheet substrates commonly used in cosmetics can be used as appropriate. Examples of the material for the sheet substrate include woven or nonwoven fabrics made of natural fibers, synthetic fibers, or semi-natural fibers. From the viewpoint of improving impregnation and usability, nonwoven fabrics are preferred.

[0040] Examples of natural fibers include cotton, pulp, silk, cellulose, hemp, linter, and kabak. Examples of synthetic fibers include nylon, polyester fiber, polyacrylic fiber, polypropylene fiber, polyethylene fiber, and polyethylene terephthalate fiber. Examples of semi-natural fibers include rayon and acetate. The above fibers may be used alone or in combination of two or more.

[0041] The surface of the sheet substrate may be embossed. The sheet substrate also includes a film substrate.

[0042] The mass ratio of the topical skin preparation according to the present embodiment impregnated into the sheet substrate in the sheet cosmetic is not particularly limited, but from the viewpoint of usability, it is preferably 100 parts by mass or more, more preferably 250 parts by mass or more, per 100 parts by mass of the sheet substrate, and from the viewpoint of usability, it is preferably 600 parts by mass or less, more preferably 500 parts by mass or less.

[0043] Sheet cosmetics are preferably stored in a packaging container from the viewpoints of preventing drying, portability when out and about, and ease of handling during use. Sheet cosmetics may be individually wrapped, or from the viewpoints of production costs, production efficiency, and the like, multiple sheets of sheet cosmetics may be stored in the same packaging container. The number of sheet cosmetics stored in one packaging container is not particularly limited, but 2 to 50 sheets (per packaging container) is preferred. In particular, since there is little difference in feel between the top and bottom sheets when using multiple sheets of sheet cosmetics stacked and stored, 10 sheets or more (per packaging container) may be used. Sheet cosmetics are preferably stored folded in half, in thirds, in quarters, cross-folded in quarters, or the like in a packaging container.

[0044] Examples of the packaging container include a bag (packaging bag) and a box-shaped container. The packaging container is preferably one that can suppress the evaporation of the topical skin preparation according to this embodiment. The material of the packaging container is not particularly limited, and examples thereof include resins such as polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP); and metals such as aluminum. From the viewpoints of being lightweight and having an excellent evaporation prevention effect, packaging containers (particularly packaging bags) made of resin with a metal layer laminated or vapor-deposited on the surface are preferred, and packaging bags made of resin with aluminum vapor-deposited on the surface are more preferred.

[0045] The topical skin preparation according to this embodiment is used by applying it to the skin. The application site of the topical skin preparation is not particularly limited, but examples include the face (e.g., forehead, cheeks, mouth, etc.), chest, back, arms, elbows, backs of the hands, fingertips, feet, knees, heels, neck, armpits, and other body parts, as well as the head (scalp). The sheet cosmetic according to this embodiment can also be applied to the same areas as the topical skin preparation.

[0046] [Spray-type deodorant] The spray-type deodorant according to this embodiment is a spray-type deodorant containing the above-mentioned sebum odor inhibitor composition. The spray formulation is not particularly limited, and examples include non-aerosol sprays such as mist sprays, and aerosol sprays. The spray-type deodorant according to this embodiment is equipped with a spray container and a spray nozzle, and the above-mentioned sebum odor inhibitor composition is filled in the spray container. Alternatively, the spray container may be an aerosol spray-type deodorant in which a propellant is further filled in addition to the above-mentioned sebum odor inhibitor composition. Furthermore, the spray-type deodorant may be a non-aerosol spray-type deodorant in which the spray nozzle is a pump-type spray nozzle. The spray-type deodorant is preferably a spray-type deodorant in which the above-mentioned sebum odor inhibitor composition is sprayed in the form of a mist.

[0047] Examples of propellants include liquefied petroleum gas (LPG), dimethyl ether (DME), diethyl ether, isobutane, isopentane, liquefied gas, and compressed gas. One type of propellant may be used alone, or two or more types may be used in combination. From the viewpoint of preventing clogging, the propellant preferably contains at least one of liquefied petroleum gas and dimethyl ether, and more preferably contains liquefied petroleum gas.

[0048] In a total of 100% by mass of the sebum odor inhibitor composition and the propellant, the content of the sebum odor inhibitor composition is preferably 10.0% by mass or more, more preferably 20.0% by mass or more, preferably 70.0% by mass or less, more preferably 60.0% by mass or less, and even more preferably 50.0% by mass or less. When the content of the sebum odor inhibitor composition is equal to or more than the above lower limit and equal to or less than the above upper limit, the dischargeability becomes even better.

[0049] The content of the propellant is preferably 30.0% by mass or more, more preferably 40.0% by mass or more, even more preferably 50.0% by mass or more, and preferably 90.0% by mass or less, more preferably 80.0% by mass or less, based on a total of 100% by mass of the sebum odor inhibitor composition and the propellant. When the content of the propellant is equal to or more than the above lower limit and equal to or less than the above upper limit, the ejection properties become even better.

[0050] The application site of the spray-type deodorant according to this embodiment is not particularly limited, and examples thereof include skin, hair, clothing, and footwear. Examples of skin include the face (e.g., forehead, cheeks, mouth, etc.), chest, back, arms, elbows, backs of the hands, fingertips, feet, knees, heels, neck, armpits, and other body skin, as well as the head (scalp). Examples of clothing include jackets, dress shirts, coats, T-shirts, sweatshirts, sweaters, jerseys, pants, slacks, jeans, skirts, dresses, underwear, pajamas, yukata, hats, scarves, bandanas, mufflers, neckties, obi belts, belts, socks, leg warmers, and tights. It is preferable to apply the spray-type deodorant to areas that frequently come into direct contact with the skin and are susceptible to sebum odor, such as the cuffs, collars, and inside of underwear and socks. Examples of footwear include shoes, sneakers, high heels, pumps, mules, boots, and insoles. It is preferable to apply the spray-type deodorant to areas susceptible to sebum odor, such as insoles.

[0051] [Hair cleanser] The hair cleanser according to this embodiment is a hair cleanser containing the sebum odor inhibitor composition. Examples of the hair cleanser include hair shampoo, hair rinse, hair conditioner, hair treatment, and rinse-in shampoo.

[0052] The content of component (A) in the hair cleanser is not particularly limited, but is preferably 0.001 to 30 mass%, more preferably 0.1 to 10 mass%, and even more preferably 0.2 to 4 mass%. The content of component (B) in the hair cleanser is not particularly limited, but is preferably 0.00001 to 20 mass%, more preferably 0.01 to 10 mass%, and even more preferably 0.1 to 6 mass%.

[0053] When the hair cleanser according to this embodiment is a hair shampoo, it preferably contains at least one surfactant selected from the group consisting of the nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants, from the viewpoint of enhancing cleansing properties. The content of the surfactant is not particularly limited, but is preferably 0.1 to 30.0% by mass.

[0054] When the hair cleanser according to this embodiment is a hair shampoo, it preferably contains water. The amount of water is not particularly limited and can be adjusted appropriately depending on the purpose of use. As the water, those exemplified as component (C) above can be used.

[0055] The hair cleanser according to this embodiment may contain any component selected appropriately within a range that does not impair the effect of the hair cleanser. Examples of the optional component include moisturizers, penetration enhancers, hair conditioning agents, pH adjusters, thickeners, viscosity modifiers, antistatic agents, chelating agents, preservatives, antioxidants, cooling agents, antibacterial agents, emulsifiers, emulsion stabilizers, herbal medicines, vitamins, proteins, fragrances, higher alcohols, silicones, oil components, and pigments. [Example]

[0056] The present invention will be described in more detail below based on examples, but the present invention is not limited to these examples.

[0057] [Example 1-1] 20 μL of a model sebum odor (a mixture containing propionic acid, hexanoic acid, heptanoic acid, octanoic acid, and nonanoic acid) was mixed with 300 μL of an aqueous solution containing 0.1% by mass of trishydroxymethylaminomethane and 0.054% by mass of sodium lauroamphoacetate as a sebum odor inhibitor composition, and the mixture was soaked into a 1.5 cm cotton pad. The cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was left to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber optic solid-phase microextraction (SPME) method, and GC-MS analysis was performed under the following conditions to measure the content of each fatty acid contained in the model sebum odor. [Analysis conditions] Column used: Agilent Technologies, product name: DB-FFAP (60 m x 0.25 mm x 0.5 μm) Gas used: Helium Temperature conditions: 40°C (maintained for 3 minutes), temperature increase from 40°C to 140°C (heating rate 7°C / min), temperature increase from 140°C to 220°C (heating rate 15°C / min) (maintained for 13 minutes), ionization method: electron ionization (EI), 60 eV

[0058] The same procedure was carried out except that the sebum odor inhibitor composition was not used, and the content of each fatty acid contained in the model sebum odor was measured. Using this as a blank, the adsorption rate when the sebum odor inhibitor composition was used was calculated using the following method. This is referred to as the "adsorption rate of odorous substances by the sebum odor inhibitor composition containing components (A) and (B)." Adsorption rate (of each fatty acid) [%] = (content of each fatty acid in blank - content of each fatty acid when sebum odor suppressant composition is used) / content of each fatty acid in blank × 100

[0059] 20 μL of the model sebum odor was mixed with 300 μL of an aqueous solution containing 0.1% by mass of trishydroxymethylaminomethane as a sebum odor inhibitor composition, and the mixture was soaked into a 1.5 cm cotton pad. The cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was left to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber for solid-phase microextraction (SPME) and analyzed by GC-MS to measure the content of each fatty acid contained in the model sebum odor. The adsorption rate was calculated in the same manner as above. This is referred to as the "adsorption rate of odorous substances by the sebum odor inhibitor composition containing only component (A)."

[0060] 20 μL of the model sebum odor was mixed with 300 μL of an aqueous solution containing sodium lauroamphoacetate at a concentration of 0.054% by mass as a sebum odor inhibitor composition, and the mixture was soaked into a 1.5 cm cotton pad. The cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was allowed to stand at 37°C for 30 minutes. After standing, the headspace gas in the vial was collected using a fiber for solid-phase microextraction (SPME) and analyzed by GC-MS to measure the content of each fatty acid contained in the model sebum odor. The adsorption rate was calculated in the same manner as above. This is referred to as the "adsorption rate of odorants by the sebum odor inhibitor composition containing only component (B)."

[0061] Based on the above results, the "adsorption rate of odorous substances by a sebum odor inhibitor composition containing components (A) and (B)" / ("adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (A)" + "adsorption rate of odorous substances by a sebum odor inhibitor composition containing only component (B)") (hereinafter referred to as "Fold") was calculated. When the Fold value is 1.0 or more, the adsorption rate when a sebum odor inhibitor composition containing components (A) and (B) is used is greater than the sum of the adsorption rates when a sebum odor inhibitor composition containing either component (A) or (B) alone is used, and therefore, the sebum odor inhibitor composition containing components (A) and (B) simultaneously exhibits a synergistic deodorizing effect.

[0062] [Examples 1-2 to 1-5, Comparative Examples 1-1 to 1-3] GC-MS analysis, adsorption rate calculation, and Fold calculation were carried out in the same manner except that the sebum odor inhibitor composition was replaced with that shown in Table 1, and the results are shown in Table 1. The abbreviations in Table 1 are explained below. TAM: Trishydroxymethylaminomethane AMP: 2-amino-2-methyl-1-propanol AMPD: 2-amino-2-methyl-1,3-propanediol LAA: Sodium lauroamphoacetate CAA: Sodium cocoamphoacetate LAP: Sodium lauraminopropionate

[0063] [Table 1]

[0064] As can be seen from Table 1, the sebum odor inhibitor composition containing trishydroxymethylaminomethane and sodium lauroamphoacetate has higher Fold values ​​than the sebum odor inhibitor composition containing these components alone, demonstrating a synergistic deodorizing effect (Comparison between Example 1-1 and Comparative Example 1-1). In particular, a high effect is demonstrated for medium-chain fatty acids (heptanoic acid, octanoic acid, nonanoic acid), which significantly influence the "smell" of sebum odor. Furthermore, the sebum odor inhibitor composition containing 2-amino-2-methyl-1,3-propanediol and sodium lauroamphoacetate has a higher Fold value for the medium-chain fatty acid heptanoic acid than the sebum odor inhibitor composition containing these components alone, demonstrating a synergistic deodorizing effect and demonstrating a remarkable effect (Comparison between Example 1-3 and Comparative Example 1-1).

[0065] [Example 2] 20 μL of the model sebum odor was mixed with 300 μL of three types of aqueous solutions as sebum odor inhibitor compositions: (1) an aqueous solution containing 0.15% by mass of trishydroxymethylaminomethane, (2) an aqueous solution containing 0.15% by mass of sodium lauroamphoacetate, and (3) an aqueous solution containing 0.1% by mass of trishydroxymethylaminomethane and 0.05% by mass of sodium lauroamphoacetate. The mixture was then soaked into a 1.5 cm cotton pad. The cotton pad was placed in a 40 mL vial, the lid was closed, and the pad was left to stand at 37°C for 30 minutes. The odor intensity was evaluated according to the following criteria. A control was used that did not contain the sebum odor inhibitor composition.

[0066] The odor intensity (odor intensity) was evaluated by a sensory evaluation in a room at 25°C by three evaluators (referred to as evaluators 1 to 3 in the table) who opened the vials after they had been left to stand and smelled them. The evaluation was based on the following criteria, and the average score of the three evaluators was calculated. The results are shown in Table 2. (Odor Intensity) 5.0 points: Quite strong smell 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak smell 1.5 points: Between 1.0 and 2.0 points 1.0: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No smell

[0067] [Table 2]

[0068] Table 2 reveals that the sample containing trishydroxymethylaminomethane and sodium lauroamphoacetate (hereinafter sometimes referred to as the "mixed sample") has a higher deodorizing effect than the sample containing either of these compounds alone (hereinafter sometimes referred to as the "single sample").

[0069] In this sensory evaluation, a reduction in odor intensity (score) indicates a significant deodorizing effect, and whether or not it exceeds 3.0 points ("clear odor") is an important factor in determining whether or not a deodorizing effect is present. The mixed sample is capable of deodorizing the model sebum odor to the point where it is no longer clearly detectable. On the other hand, the single sample was found to be less effective than the mixed sample and to have an extremely low deodorizing effect compared to the control. In other words, the single sample showed almost no deodorizing effect, but the mixed sample showed an extremely high deodorizing effect. Thus, the difference in odor intensity between the mixed sample and the single sample indicates the significant deodorizing effect of using the mixed sample. In other words, it can be seen from Table 2 that the inclusion of both trishydroxymethylaminomethane and sodium lauroamphoacetate results in a synergistic deodorizing effect.

[0070] [Example 3] As samples for evaluating the deodorizing effect, an aqueous solution containing 10% by mass of trishydroxymethylaminomethane, an aqueous solution containing 0.27% by mass of sodium lauroamphoacetate, and an aqueous solution containing 10% by mass of trishydroxymethylaminomethane and 0.27% by mass of sodium lauroamphoacetate were prepared. The pH of each of these solutions was 6.0.

[0071] The subjects were asked to use new, sterilized shoe insoles for 30 consecutive days, and the odor intensity of the used insoles was evaluated (1) before spraying the sample, (2) 3 minutes after spraying the sample, and (3) 30 minutes after spraying the sample.

[0072] The odor intensity evaluation (odor intensity) was carried out by a sensory evaluation in which three evaluators smelled each insole after continuous use in a room at 25°C. The evaluation was based on the following criteria, and the average score of the three evaluators was calculated. The results are shown in Figure 1. (Odor Intensity) 5.0 points: Quite strong smell 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak smell 1.5 points: Between 1.0 and 2.0 points 1.0: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No smell

[0073] FIG. 1 reveals that the sample containing trishydroxymethylaminomethane and sodium lauroamphoacetate (hereinafter sometimes referred to as the "mixed sample") had a higher deodorizing effect than the sample containing either of these compounds alone (hereinafter sometimes referred to as the "single sample"), both "3 minutes after spraying" and "30 minutes after spraying."

[0074] In this sensory evaluation, a decrease in odor intensity (score) indicates a significant deodorizing effect, and whether or not the odor intensity exceeds 3.0 points ("clear odor") is an important factor in determining whether or not a deodorizing effect is present. Based on the results "30 minutes after spraying," when the mixed sample was used, the odor intensity was lower than "weak odor" and approached "faint odor." In other words, the mixed sample was able to deodorize the insole to the point where the odor could no longer be clearly detected. On the other hand, the single sample was less effective at deodorizing than the mixed sample. Thus, the difference in odor intensity between the mixed sample and the single sample can be said to indicate the significant deodorizing effect of the mixed sample. In other words, it can be seen from Figure 1 that the inclusion of both trishydroxymethylaminomethane and sodium lauroamphoacetate provides a synergistic deodorizing effect.

[0075] [Example 4] A comparative product was prepared using the same formulation as Lucido Scalp Deo Shampoo (manufactured by Mandom Corporation). Test product A was prepared using the same formulation as Lucido Scalp Deo Shampoo, except that the trishydroxymethylaminomethane concentration was 0.5% by mass and the sodium lauroamphoacetate concentration was 0.3% by mass. Test product B was prepared using the same formulation as Lucido Scalp Deo Shampoo, except that the trishydroxymethylaminomethane concentration was 1.0% by mass and the sodium lauroamphoacetate concentration was 0.6% by mass. The comparative product and test products A and B were each used by nine subjects (a total of 27 subjects, 9 subjects x 3 groups) for two consecutive weeks.

[0076] After two weeks of continuous use, the scalp odor was evaluated approximately 24 hours after the last use (hereinafter referred to as "scalp odor before washing"). Then, the hair was washed with the comparison product, test product A, or test product B that had been used continuously for the two weeks, and the scalp odor immediately after washing (hereinafter referred to as "scalp odor after washing") was evaluated. The scalp odor evaluation was performed by a panel of three experts. The average scores for the scalp odor before washing and the scalp odor after washing for each subject group were calculated, and the odor intensity was evaluated by the difference between the average scores ("average score for scalp odor after washing" - "average score for scalp odor before washing"). The evaluation was performed based on the following criteria. The results are shown in Figure 2. (Odor Intensity) 5.0 points: Quite strong smell 4.5 points: Between 4.0 and 5.0 points 4.0 points: Slightly strong odor 3.5 points: Between 3.0 and 4.0 points 3.0 points: Clear odor 2.5 points: Between 2.0 and 3.0 points 2.0 points: Weak smell 1.5 points: Between 1.0 and 2.0 points 1.0: Slight odor 0.5 points: Between 0 and 1.0 points 0 points: No smell

[0077] The change in scalp odor intensity (average scalp odor score after washing minus average scalp odor score before washing) was -0.37 points for the comparison product, -0.57 points for test product A, and -0.69 points for test product B (Figure 2). This demonstrates that the sebum odor suppressant composition of the present invention has an excellent scalp odor suppressing effect.

[0078] Formulation examples of the sebum odor suppressant composition of the present invention are shown below.

[0079] (Prescription Example 1) Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass Polyoxyethylene (6) glyceryl monoisostearate 2.0% by mass Polyoxyethylene (20) glyceryl monoisostearate 2.0% by mass Lauryl amidopropyl betaine 1.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Diglycerin 1.0% by mass 1,3-butylene glycol 10.0% by mass Ethanol 5.0% by mass l-Menthol 0.5% by mass Acrylic acid / alkyl methacrylate copolymer 0.4% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0080] (Prescription example 2) Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass Polyoxyethylene (8) glyceryl monoisostearate 4.0% by mass Polyoxyethylene glyceryl ether (9) 3.0% by mass Sodium lauroamphoacetate 0.3% by mass Trishydroxymethylaminomethane 0.5% by mass Dipropylene glycol 10.0% by mass Ethanol 7.0% by mass l-Menthol 0.3% by mass Acrylic acid / alkyl methacrylate copolymer 0.2% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0081] (Prescription Example 3) Sodium polyoxyethylene lauryl ether sulfate 10.0% by mass Polyoxyethylene (6) glyceryl monoisostearate 1.5% by mass Polyoxyethylene (20) glyceryl monoisostearate 3.5% by mass Lauryl amidopropyl betaine 2.5% by mass Coconut oil fatty acid diethanolamide 3.0% by mass Lauryl dimethylaminoacetic acid betaine 4.2% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Sorbitol 1.0% by mass 1,3-butylene glycol 0.5% by mass l-Menthol 1.0% by mass O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride 0.3% by mass Polydimethylmethylene piperidium chloride solution 0.1% by mass Ethylene glycol distearate 1.0% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0082] (Prescription Example 4) Sodium polyoxyethylene lauryl ether sulfate 6.0% by mass Lauryl dimethylaminoacetic acid betaine 2.0% by mass Polyoxyethylene lauryl ether sodium acetate 3.0% by mass Disodium lauryl sulfosuccinate 1.0% by mass Coconut oil fatty acid diethanolamide 5.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass O-[2-hydroxy-3-(trimethylammonio)propyl] chloride Hydroxyethyl cellulose 0.2% by mass Dipotassium glycyrrhizinate 0.2% by mass l-Menthol 1.0% by mass Ethanol 3.0% by mass Sodium chloride (appropriate amount) Ethylenediaminetetraacetate (appropriate amount) Sodium benzoate (appropriate amount) Fragrance (appropriate amount) Purified water remainder Total 100.0% by mass

[0083] (Prescription Example 5) Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass Polyoxyethylene (20) sorbitan monoisostearate 2.0% by mass Polyoxyethylene (100) hydrogenated castor oil 2.0% by mass Lauryl amidopropyl betaine 1.0% by mass Sodium lauroamphoacetate 0.3% by mass Trishydroxymethylaminomethane 0.5% by mass Diglycerin 1.0% by mass 1,3-butylene glycol 10.0% by mass Ethanol 5.0% by mass l-Menthol 0.5% by mass Acrylic acid / alkyl methacrylate copolymer 0.4% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0084] (Prescription Example 6) Sodium polyoxyethylene lauryl ether sulfate 2.0% by mass Polyoxyethylene (8) glyceryl monoisostearate 2.5% by mass Polyoxyethylene (100) hydrogenated castor oil 1.5% by mass Polyoxyethylene glyceryl ether (9) 3.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Dipropylene glycol 10.0% by mass Ethanol 7.0% by mass l-Menthol 0.3% by mass Acrylic acid / alkyl methacrylate copolymer 0.2% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0085] (Prescription Example 7) Sodium polyoxyethylene lauryl ether sulfate 10.0% by mass Polyoxyethylene (50) hydrogenated castor oil 1.5% by mass Polyoxyethylene (20) glyceryl monoisostearate 3.5% by mass Lauryl amidopropyl betaine 1.5% by mass Coconut oil fatty acid diethanolamide 3.0% by mass Lauryl dimethylaminoacetic acid betaine 1.5% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Sorbitol 1.0% by mass 1,3-butylene glycol 0.5% by mass l-Menthol 1.0% by mass O-[2-hydroxy-3-(trimethylammonio)propyl] chloride Hydroxyethyl cellulose 0.3% by mass Polydimethylmethylene piperidium chloride solution 0.1% by mass Ethylene glycol distearate 1.0% by mass pH adjuster (appropriate amount) Purified water remainder Total 100.0% by mass

[0086] (Prescription Example 8) Sodium laureth sulfate 10.0% by mass Cocamidopropyl betaine 5.0% by mass Coconut oil fatty acid N-methylethanolamide 5.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Polyquaternium-10 0.5% by mass Ethanol 2.0% by mass Phenoxyethanol 0.3% by mass Sodium chloride (appropriate amount) pH adjuster (appropriate amount) Sodium benzoate (appropriate amount) Fragrance (appropriate amount) Purified water remainder Total 100.0% by mass

[0087] (Prescription Example 9) Glycerin 15.0% by mass Lauramidopropyl hydroxysultaine 2.5% by mass Sodium lauroamphoacetate 0.3% by mass Trishydroxymethylaminomethane 0.5% by mass Sodium lauroylmethylalanine 6.0% by mass O-[2-hydroxy-3-(trimethylammonio)propyl] chloride Hydroxyethyl cellulose 0.3% by mass Xanthan Hydroxypropyltrimonium Chloride 0.3% by mass Polyquaternium-10 0.2% by mass Phenoxyethanol 0.3% by mass Glutamic acid 0.1% by mass pH adjuster (appropriate amount) Ethylenediaminetetraacetate (appropriate amount) Sodium benzoate (appropriate amount) Purified water remainder Total 100.0% by mass

[0088] (Prescription Example 10) Cocoyl hydrolyzed keratin K 7.0% by mass Lauroyl hydrolyzed silk sodium 5.0% by mass Sodium lauroylmethylalanine 5.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Polyquaternium-10 0.5% by mass O-[2-hydroxy-3-(trimethylammonio)propyl] chloride Hydroxyethyl cellulose 0.3% by mass PPG-2 Cocamide 1.5% by mass Ceteareth-60 Myristyl Glycol 1.0% by mass Polyoxyethylene cetyl stearyl diether 0.5% by mass Dipropylene glycol 5.0% by mass L-arginine 0.1% by mass pH adjuster (appropriate amount) Methylparaben (appropriate amount) Fragrance (appropriate amount) Purified water remainder Total 100.0% by mass

[0089] (Prescription Example 11) Sodium polyoxyethylene lauryl ether sulfate 15.0% by mass Coconut oil fatty acid amidopropyl betaine 10.0% by mass Polyoxyethylene (10) lauryl ether 5.0% by mass Diethylene glycol distearate 2.0% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Glycerin 10.0% by mass Palmitic acid 1.0% by mass Stearyl alcohol 1.0% by mass Alkyltrimethylammonium chloride 1.5% by mass Phenoxyethanol 0.3% by mass Polyquaternium-10 (appropriate amount) pH adjuster (appropriate amount) Ethylenediaminetetraacetate (appropriate amount) Sodium benzoate (appropriate amount) Fragrance (appropriate amount) Purified water remainder Total 100.0% by mass

[0090] (Prescription Example 12) Sodium methyl cocoyl taurate 5.0% by mass Sodium lauroyl sarcosinate 5.0% by mass Lauryl betaine 3.0% by mass Coconut oil fatty acid N-methylethanolamide 1.0% by mass Ethyl isostearate 0.1% by mass Sodium lauroamphoacetate 0.6% by mass Trishydroxymethylaminomethane 1.0% by mass Glycol distearate 1.0% by mass pH adjuster (appropriate amount) Polyquaternium-10 (appropriate amount) Fragrance (appropriate amount) Methylparaben (appropriate amount) Purified water remainder Total 100.0% by mass

Claims

1. A sebum odor inhibitor composition containing the following components (A) and (B): A sebum odor suppressant composition, wherein the content of component (A) in the sebum odor suppressant composition is 0.001 to 10 mass %. Component (A): At least one polyhydroxyamine compound selected from the group consisting of trishydroxymethylaminomethane and 2-amino-2-methyl-1,3-propanediol Component (B): Sodium lauroamphoacetate

2. A skin external preparation containing the sebum odor inhibitor composition according to claim 1.

3. A spray-type deodorant containing the sebum odor suppressant composition according to claim 1.

4. A hair cleanser containing the sebum odor inhibitor composition according to claim 1.

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