Surfactant-free foaming oral care composition

Abstract

The present invention is a surfactant-free foaming oral care composition. The oral care composition of the present invention contains 0.1-10% (w / w) methylcellulose, and the surface tension of the methylcellulose at a concentration of 0.1% by mass in an aqueous solution is less than 60 mN / m, preferably 47-59 mN / m. The content of methylcellulose in the composition is 0.1-10 wt. %, preferably 0.5-10 wt. %, more preferably 1-7 wt. %, particularly preferably 2-5 wt. %, and particularly preferably 2.5-4.0 wt. The oral care composition does not contain a surfactant and can foam when brushing teeth.

Description

[Technical Field]

[0001] This application claims priority from a Chinese patent application with application number CN2020110111010.7 filed with the China Patent Office on September 23, 2020, the entire contents of which are incorporated herein by reference. The present disclosure relates to oral care compositions, particularly to surfactant-free oral care compositions, and especially to surfactant-free foaming toothpaste compositions. [Background technology]

[0002] Toothpaste is an essential daily necessities for people. As a product that comes into direct contact with the oral cavity every day, the safety and health effects of toothpaste have attracted people's attention. Toothpaste is a complex mixture of ingredients, usually composed of abrasives, humectants, surfactants, thickeners, fragrance essences, sweeteners, colorants, and antiseptics.

[0003] Surfactants are essential ingredients in toothpaste. For example, U.S. Patent Application Publication No. 4,058,595 discloses surfactants commonly used in toothpaste, such as alkylarylsulfonates, higher alkylsulfoacetates, higher fatty acid amides of taurine, and sorbitan monostearate. However, these synthetic surfactants and their decomposition products can cause mucosal irritation, skin allergies, toxicity, and carcinogenicity, and can damage the ecological environment of the skin and oral cavity, including the destruction of skin taste cells and oral cells. Residual chemical components can damage the ecological environment of the oral cavity and even penetrate the oral mucosa and enter the bloodstream, posing a potentially serious safety risk. Therefore, the safety of toothpaste is of great concern to consumers.

[0004] To reduce the potential safety risks of surfactants, mild toothpastes have been developed. These types of mild toothpastes use relatively mild surfactants, such as sodium lauroyl sarcosinate, alkyl glycosides, cocamidopropyl betaine, and natural surfactants (soysaponins). However, when our research team conducted laboratory experiments on mung beans using toothpaste solutions of specified concentrations, we found that even when toothpaste containing these surfactants was diluted 20 times with water, the mung beans were unable to germinate. This research indicates that the presence of surfactants reduces the safety of toothpaste, but that potential safety risks remain.

[0005] Additionally, surfactant alternatives have been developed for use in toothpaste compositions.

[0006] Chinese Patent Publication No. 103211716 discloses a method for producing toothpaste using surface-active proteins or protein-based surfactants as unique cleaning and washing ingredients, where the surface-active proteins or protein-based surfactants are one, two, three or four of soy protein sodium, silk protein calcium, natural silk protein emulsifier or sodium caseinate.

[0007] U.S. Patent Application Publication No. 2006222602 discloses a toothpaste composition for cleaning teeth. The calcium salt component of the toothpaste contains nanoparticles and a protein component, such as soy protein or casein. The toothpaste composition further contains an anionic surfactant, a zwitterionic or amphoteric surfactant, a nonionic surfactant, a cationic surfactant, or a mixture of these compounds. The toothpaste composition has a gentle treatment and cleaning effect.

[0008] Chinese Patent Application Publication No. 108261343 discloses a toothpaste composition containing 0.05-5.5% calcium caseinate based on the total weight of the toothpaste composition, and the alternative surfactant is expensive.

[0009] To reduce the potential safety risks posed by surfactants, surfactant-free toothpastes have been developed. However, these toothpastes are unable to foam when brushing teeth, resulting in an inferior user experience and low acceptance.

[0010] Therefore, there is a need to develop surfactant-free and preservative-free oral care compositions, particularly toothpaste compositions, while maintaining user comfort. [Prior art documents] [Patent documents]

[0011] [Patent Document 1] US Patent Application Publication No. 4,058,595 [Patent Document 2] Chinese Patent Application Publication No. 103211716 [Patent Document 3] U.S. Patent Application Publication No. 2006222602 [Patent Document 4] Chinese Patent Application Publication No. 108261343 Summary of the Invention [Means for solving the problem]

[0012] Cellulose-type naturally occurring polymers are commonly used as thickeners in toothpastes. Researchers have discovered that oral care compositions can be foamed even in the absence of surfactants by using specific methylcellulose as a thickener, and have completed the present invention based on this discovery.

[0013] Accordingly, the present disclosure relates to foamable oral care compositions comprising 0.1 to 10 wt. % methylcellulose, based on the weight of the oral care composition, wherein the surface tension of the methylcellulose in aqueous solution at a concentration of 0.1 wt. % is less than 60 mN / m, preferably 47 to 59 mN / m, and particularly preferably 48 to 53 mN / m. Component contents in compositions of the present disclosure are understood to be weight percent (w / w).

[0014] In some embodiments, the present disclosure relates to oral care compositions, such oral care compositions comprising: (a) 10 to 50% (w / w), preferably 12 to 40% (w / w), particularly preferably 15 to 30% (w / w), in particular 18 to 25% (w / w) of an abrasive; (b) 5 to 50% (w / w), preferably 10 to 45% (w / w), particularly preferably 15 to 40% (w / w), in particular 18 to 30% (w / w) of a moisturizer; (c) 0.01 to 2.0% (w / w), preferably 0.1 to 1.0% (w / w), more preferably 0.5 to 1.0% (w / w) of a flavoring agent, and (d) 0.01 to 10% (w / w), preferably 0.1 to 5% (w / w), more preferably 1.0 to 2.0% (w / w) of a functional additive (e) 0.1 to 10% (w / w), preferably 0.5 to 10% (w / w), more preferably 1 to 7% (w / w), particularly preferably 2 to 5% (w / w), and particularly preferably 2.5 to 4.0% (w / w) of methylcellulose Includes:

[0015] In at least one embodiment, the oral care composition of the present disclosure comprises: (a) 10 to 50% (w / w), preferably 12 to 40% (w / w), particularly preferably 15 to 30% (w / w), in particular 18 to 25% (w / w) of an abrasive; (b) 5 to 50% (w / w), preferably 10 to 45% (w / w), particularly preferably 15 to 40% (w / w), in particular 18 to 30% (w / w) of a moisturizer; (c) 2 to 20% (w / w), preferably 4 to 16% (w / w), particularly preferably 6 to 12% (w / w), in particular 8 to 10% (w / w) of cellulose; (d) 5 to 30% (w / w), preferably 8 to 26% (w / w), particularly preferably 12 to 22% (w / w), and particularly preferably 14 to 18% (w / w) of a lactic acid bacteria fermentation compound; (e) 0.1 to 10% (w / w), preferably 0.5 to 10% (w / w), more preferably 1 to 7% (w / w), particularly preferably 2 to 5% (w / w), and particularly preferably 2.5 to 4.0% (w / w) of methylcellulose; and (f) 1 to 12% (w / w), preferably 2 to 10% (w / w), particularly preferably 3 to 8% (w / w), particularly preferably 4 to 6.0% (w / w) of starch Includes:

[0016] Methylcellulose (MC) In the oral care composition of the present disclosure, the surface tension of a 0.1% aqueous solution of methylcellulose is less than 60 mN / m, and preferably 47 to 59 mN / m.

[0017] To obtain an acceptable foaming effect, the amount of methylcellulose of the present disclosure used is 0.1 to 10% (w / w), preferably 0.5 to 10%, more preferably 1 to 7%, particularly preferably 2 to 5%, and especially 2.5 to 4.0%, based on the oral care composition.

[0018] In some embodiments, commercially available methylcellulose is selected, for example, 55HD400FG (food grade) and 55HD400 (medical grade) from Shandong HEAD Co., Ltd.

[0019] abrasives In some embodiments of the present disclosure, the oral care composition contains a dentally acceptable abrasive material or abrasive that can be used to polish tooth enamel or provide a whitening effect, provided that the oral care composition medium is a solid or paste. Any orally acceptable abrasive may be used. However, the type, conformity (particle size), and amount of abrasive should be selected so that normal use of the composition does not excessively wear away tooth enamel. Suitable abrasives include, but are not limited to, silica gel, silicon dioxide in the form of silicon dioxide hydrate or precipitated silicon dioxide, aluminum oxide, insoluble phosphates, calcium carbonate, and resin-based abrasives such as urea-formaldehyde condensates. Insoluble phosphates used as abrasives include orthophosphates, polymetaphosphates, and pyrophosphates. Typical examples are calcium orthophosphate dihydrate, calcium pyrophosphate, β-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, and insoluble sodium polymetaphosphate. One or more abrasives are optionally present in an effective total abrasive amount, typically about 10-50%, eg, 12-40%, 15-30%, or 18-25% of the composition.

[0020] moisturizer Humectants that can be used in the present disclosure include polyhydric alcohols, such as glycerol, sorbitol, xylitol, and polyethylene glycol. In various embodiments, humectants can be used to prevent hardening of the paste or gel composition when exposed to air, and the humectant also acts as a sweetener. One or more humectants are optionally present in a total amount of 5-50%, preferably 10-45%, particularly preferably 15-40%, and especially 18-30%.

[0021] thickener Thickeners are typically used in oral care compositions to control or modify the viscosity of the composition. Provided that the toothpaste does not affect the foam of the toothpaste, the toothpaste according to at least one embodiment of the present disclosure comprises a thickener other than methylcellulose, the thickener being selected from polysaccharides or polysaccharide derivatives (e.g., hydroxypropylmethylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose and other cellulose derivatives, and starch), carbomers (e.g., cross-linked polyacrylic acid copolymers or acrylic acid homopolymers and copolymers cross-linked with polyalkenyl polyethers), natural and synthetic gums (e.g., carrageenan, xanthan gum, karaya gum, guar gum, gelatin, algin, sodium alginate, tragacanth gum, chitosan, and acacia gum), acrylamide polymers, acrylic acid polymers, vinyl polymers (e.g., polyvinyl alcohol and polyvinylpyrrolidone), polyamines, polyquaternary compounds, ethylene oxide polymers, and mixtures thereof. In some embodiments, clays, organically modified clays, some inorganic thickeners such as silicon dioxide, and mixtures thereof are used in the present disclosure.

[0022] Flavoring agent Flavoring agents used in the present disclosure include any substance or mixture of substances that can improve the taste of the composition. Any orally acceptable natural or synthetic flavoring agent can be used, such as flavor oils, flavor aldehydes, esters, alcohols, analogs, and combinations thereof. Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, wintergreen oil, peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oil, fruit oils, and essences derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, and pineapple, among others. One or more flavoring agents may optionally be present in a total amount of 0.01 to 5%.

[0023] In some embodiments, the flavoring agent used in the present disclosure comprises an orally acceptable natural or artificial, nutritive or non-nutritive sweetener. Sweeteners of this type include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup, sorbitol, mannitol, xylitol, maltitol, isomaltitol, aspartame, neotame, saccharin, and salts thereof, sucralose, and mixtures thereof. One or more sweeteners are optionally present in an amount of about 0.005-10%, optionally about 0.01-1%.

[0024] Selective active substances The compositions of the present disclosure may optionally contain one or more additional active agents and may be used to prevent or treat a disease or disorder of hard or soft tissues in the oral cavity, to prevent or treat a physiological disorder or disease, or to provide a cosmetic benefit. In various implementations, the active agent is an "oral care active" that may be used to treat or prevent a disorder or to provide a cosmetic benefit in the oral cavity (e.g., teeth, gums, or other oral hard or soft tissues). Oral care actives that may be used in the present disclosure include colorants, corrosion inhibitors, anti-caries agents, anti-plaque agents, anti-tartar agents, anti-inflammatory agents, deodorizing agents, desensitizing agents, or combinations thereof.

[0025] Active agents that can be used in the present disclosure are present in the compositions of the present disclosure in safe and effective amounts, if necessary. A "safe and effective" amount of an active agent is an amount sufficient to use the active agent to produce the desired therapeutic or preventative effect in a human or lower animal subject without undue side effects (e.g., toxicity, irritation, or allergic reaction). A reasonable benefit / risk ratio is recognized for application in the methods of the present disclosure. The specific safe and effective amount of an active agent may vary depending on factors such as the particular disease being treated, the subject's physical health, the characteristics of concurrent treatments (if any), the particular active agent used, the particular dosage form, the carrier used, and the required administration schedule.

[0026] pH adjuster pH adjusting agents usable in the present disclosure include pH-lowering acidifying agents, pH-elevating basifying agents, and buffering agents for controlling pH within the required range, e.g., one or more compounds selected from acidifying agents, basifying agents, and buffering agents to provide a pH of approximately 2 to 10. Any orally acceptable pH adjusting agent may be used, including carboxylic acids, phosphoric acids, sulfonic acids, acid salts (e.g., monosodium citrate, di-sodium citrate, monosodium maleate), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, and phosphates (e.g., monosodium phosphate, trisodium phosphate, and polyphosphates). The one or more pH adjusting agents are optionally present in a total amount effective to maintain the composition within an orally acceptable pH range.

[0027] water In various embodiments of the present disclosure, water is also present in the oral compositions, and in at least one embodiment, deionized water free of organic impurities is used. The added water is free water unless introduced with other substances, such as sorbitol. Water typically comprises 10-50%, preferably 15-35%, of the toothpaste compositions of the present disclosure.

[0028] surfactants In another embodiment, the oral care composition of the present disclosure is a surfactant-free composition. The term "surfactant," also referred to as an interfacial agent, refers to a substance capable of reducing the surface tension of a liquid or the interfacial tension between two phases. Surfactants are amphiphilic and contain both hydrophilic and lipophilic groups. Examples of hydrophilic groups include, but are not limited to, amino groups, carboxy groups, sulfonic acid groups, and hydroxy groups. Examples of hydrophobic groups include, but are not limited to, C8 or higher aliphatic alkanes, alkenes, alkynes, aromatic hydrocarbons, and the like. Examples of commonly used surfactants include, but are not limited to, natural surfactants or their derivatives, and synthetic surfactants. Examples of natural surfactants or their derivatives include protein-based surfactants.

[0029] Exemplary anionic surfactants are, for example, water-soluble salts of higher fatty acid monoglyceride monosulfates, such as sodium salts of monosulfated monoglycerides of hydrogenated coconut oil fatty acids, e.g., sodium N-methyl N-cocoyl taurate, and sodium cocoglyceride sulfate, higher alkyl sulfates (e.g., sodium lauryl sulfate), higher alkyl ether sulfates (e.g., sodium laureth 2-sulfate), higher alkyl aryl sulfonates (e.g., sodium dodecylbenzenesulfonate), and higher alkyl sulfoacetates (e.g., sodium lauryl sulfoacetate), higher fatty acid esters of 1,2-dihydroxypropanesulfonic acid, sulfolaurates, and sodium lauryl sarcosinate.

[0030] With respect to the cationic surfactants of the present disclosure, cationic surfactants can be broadly defined as derivatives of aliphatic quaternary ammonium compounds having alkyl chains of C8 to C18 length, such as, for example, lauryltrimethylammonium chloride, cetylpyridinium chloride, cetyltrimethylammonium bromide, diisobutylphenoxyethyldimethylbenzylammonium chloride, cocoalkyltrimethylammonium nitrite, cetylpyridinium fluoride, and mixtures thereof.

[0031] Exemplary nonionic surfactants can be broadly defined as compounds produced by condensing an alkylene oxide group with a hydrophobic organic compound, which can be substantially aliphatic or alkylaromatic. Examples of suitable nonionic surfactants include, but are not limited to, polyethylene oxide condensates of alkyl phenols, condensation products derived from the reaction product of ethylene oxide, propylene oxide and ethylenediamine, ethylene oxide condensates of aliphatic alcohols, long-chain tertiary amine oxides, long-chain tertiary phosphine oxides, long-chain dialkyl sulfoxides, and mixtures of these types of materials, such as poloxamers, polysorbates, and polyethylene glycol hydrogenated castor oil.

[0032] Exemplary amphoteric surfactants include betaines (e.g., cocamidopropyl betaine); derivatives of aliphatic secondary and tertiary amines, where the aliphatic group can be straight or branched, one of the aliphatic substituents contains about 8 to 18 atoms, and one contains an anionic water-solubilizing group (e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate); and mixtures of this type of material.

[0033] In another embodiment, the present invention is free of preservatives and bacteriostats, which are selected from alcohols, formaldehyde donors and aldehyde derivatives, benzoic acid and its derivatives, and other organic compounds such as phenoxyethanol and benzyl alcohol, imidazolidinyl urea, parabens, bronopol, carbazones, and quaternary amine salts.

[0034] Without being bound by theory, the water activity of the oral care composition is controlled through the use of a high content of humectants, such as water-soluble small molecules, such as glycerol, sorbitol, xylitol, and isomaltitol, and natural high molecular weight polymers, thereby inhibiting microbial growth. The water activity of the oral care composition (as toothpaste) of the present disclosure is less than 0.75, preferably less than 0.65, and particularly less than 0.6. [Brief explanation of the drawings]

[0035] [Figure 1] 1 shows a comparison of the foaming capacity of toothpastes. [Figure 2] Mung bean conditions after 15 hours of the M1 experiment are shown. [Figure 3] Mung bean conditions after 15 hours of the M2 experiment are shown. [Figure 4] Mung bean conditions after 15 hours of the M3 experiment are shown. [Figure 5] Mung bean conditions after 15 hours of the M4 experiment are shown. [Figure 6] Mung bean conditions after 15 hours of the M5 experiment are shown. [Figure 7] Mung bean conditions after 15 hours of the M6 ​​experiment are shown. [Figure 8] Embodiment 1# shows mung bean conditions after 15 hours of the experiment. [Figure 9] Embodiment 1# shows mung bean conditions after 15 hours of the experiment. [Figure 10] Embodiment 1# shows mung bean conditions after 15 hours of the experiment. [Figure 11] Embodiment 1# shows mung bean conditions on day 5 of the experiment. [Figure 12] Embodiment 1# shows mung bean conditions on day 7 of the experiment. DETAILED DESCRIPTION OF THE INVENTION

[0036] The present disclosure may be more clearly understood by reading the following aspects, which are not intended to limit the present invention but are merely exemplary embodiments of the present disclosure. Unless otherwise specified, the following aspects are in weight percent.

[0037] The oral care composition is prepared based on the following proportions: Formulation of Embodiment 1#: 55 parts sorbitol (70% sorbitol in water), 22 parts dicalcium phosphate, 5.5 parts glycerol, 5.5 parts xylitol, 2.2 parts cellulose, 2.2 parts starch, 4.6 parts lactic acid bacteria fermentation compound, and 3.0 parts MC (X1).

[0038] Formulation of Embodiment 2#: 52.5 parts sorbitol (70% sorbitol in water), 22 parts dicalcium phosphate, 8 parts glycerol, 5.5 parts xylitol, 2.2 parts cellulose, 2.2 parts starch, 4.6 parts lactic acid bacteria fermentation compound, and 3.0 parts MC(X2).

[0039] Formulation of Embodiment 3#: 50 parts sorbitol (70% sorbitol in water), 22 parts dicalcium phosphate, 10.5 parts glycerol, 5.5 parts xylitol, 2.2 parts cellulose, 2.2 parts starch, 4.6 parts lactic acid bacteria fermentation compound, and 3.0 parts MC(X3).

[0040] The oral care composition is prepared based on the following proportions: That is, 50 parts sorbitol (70% sorbitol aqueous solution), 22 parts dicalcium phosphate, 10.5 parts glycerol, 5.5 parts xylitol, 2.2 parts cellulose, 2.2 parts starch, 4.6 parts lactic acid bacteria fermentation compound, and 3.0 parts MC(Xn * ). Note: Xn refers to various models of MC, where n is 4, 5, 6 etc.

[0041] Surface Tension Test Method MC was prepared in a 0.1% aqueous solution, and the surface tension of the solution was measured with a JYW-200C fully automatic surface tensiometer. Foaming test method The foaming performance of toothpaste was measured according to the following method: A 4 cm length of toothpaste was extruded onto the surface of a rough stone. The rough stone was pre-wetted, and the toothbrush was wetted to brush repeatedly for 1 minute, simulating the frequency of a real toothbrush. The foaming performance of the toothpaste was observed and rated on a scale of 0 to 4. When the composition was used as toothpaste, a foaming performance of 2 indicated some foaming ability, 3 and 4 indicated good foaming effect, and 0 indicated no foaming.

[0042] Table 1: Surface tension of MC and foaming capacity of the composition [Table 1]

[0043] Comparative Example 4#: Commercially available toothpaste containing a surfactant, the surfactant being sodium lauroyl sarcosinate. The results are shown in Figure 1 and Table 1. The surface tension of 0.1% aqueous solutions of the selected MCs was 47-59 mN / m, and the toothpaste of the present disclosure had almost the same foaming effect as commercially available surfactant-containing toothpastes.

[0044] Stability testing Table 2: Water activity Aw of the three toothpaste compositions [Table 2]

[0045] Bacterial medium for antiseptic challenge test: Lecithin TWEEN® 80 agar (obtained from Hopebio): 24.0 g of medium (Lecithin TWEEN® 80 agar) was placed in a 1000 ml Erlenmeyer flask, heated to a boil, and dissolved in 500 ml of distilled water. The mixture was autoclaved at 121°C for 20 minutes before use.

[0046] Fungal media: Potato dextrose agar (PDA) and rose bengal agar (obtained from Beijing Luqiao): 18.3 g of the medium (one of the above two media, rose bengal agar in this example) was placed in a 1000 ml Erlenmeyer flask, dissolved in 500 ml of distilled water, heated to a boil, and heated until completely dissolved. Sterilized under high pressure at 121°C for 15 minutes before use.

[0047] Physiological saline: High-pressure sterilization was performed at 121°C for 15 minutes before use.

[0048] Strains tested: Escherichia coli, ATCC 8739 Pseudomonas aeruginosa, ATCC 9027 Staphy Lo Coccus Aureus, ATCC 6538 Candida Albicans, ATCC 10231 Aspergiblus Niger, ATCC 16404

[0049] Experimental Method This experiment was conducted in accordance with the United States Pharmacopoeia USP39 <51> The test was based on the microbial antiseptic effect test method. 30 g of each sample to be tested was weighed and placed in a sterilized sample bottle. A quantitatively mixed bacterial suspension (above 5 strains) was added. The initial concentration of bacteria (Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) added to the sample was 10 6 The initial bacterial loading concentrations of Candida Albicans and Aspergiblus Niger were 10 5 The total number of bacteria was 10 ...

[0050] Evaluation criteria The log reduction in total bacterial counts from the initial value to day 7 was not less than 1.0; the log reduction in total bacterial counts from the initial value to day 14 was not less than 3.0; and the bacterial counts did not increase from day 14 to day 28. The total bacterial counts of Candida albicans and Aspergiblus niger did not increase from the initial value to days 7, 14, and 28.

[0051] Table 3: Colony counts over time [Table 3]

[0052] The anticorrosion agent-free samples of the toothpaste compositions of the three embodiments were subjected to a microbial challenge test. The results show that these compositions passed the challenge test. Therefore, the present disclosure shows that the anticorrosion effect can be achieved by controlling the water activity Aw to be less than 0.7.

[0053] Safety Experiments Mung bean germination experiment Plant life begins with seed germination. Water is an essential condition for germination and sprout growth. The presence of contaminants (chemical ingredients in toothpaste) in water inhibits seed germination and sprout (seedling) growth. This experiment analyzes the safety or potential danger of toothpaste ingredients through the effect of toothpaste water solution on mung bean seed germination.

[0054] (1) Tested toothpaste samples Table 4: Toothpaste samples tested [Table 4] Note: M1-M6 are commercially available toothpastes, and "-" indicates surfactant-free.

[0055] (2) Test method The toothpaste was diluted 20 times with pure water in a culture dish. Six healthy mung beans were placed in the culture dish and observed for sprout germination and growth to test the safety and potential toxicity of the toothpaste ingredients.

[0056] (3) Test results Table 5: Test results [Table 5] Within the range of the above study, none of the mung beans left in the commercially available toothpaste germinated (Figures 2 to 7). However, all of the mung beans left in the surfactant-free toothpaste provided by the present invention germinated 100% (Figures 8 to 10), and the subsequent seeds also grew well (Figures 11 and 12). The present invention provides, for example, the following items. (Item 1) A foamable oral care composition comprising methylcellulose, wherein the surface tension of the methylcellulose at a concentration of 0.1% by mass in an aqueous solution is less than 60 mN / m, preferably 47 to 59 mN / m, and the content of the methylcellulose in the composition is 0.1 to 10% by weight, preferably 0.5 to 10% by weight, more preferably 1 to 7% by weight, particularly preferably 2 to 5% by weight, and particularly preferably 2.5 to 4.0% by weight, based on the weight of the composition. (Item 2) (a) 10 to 50% (w / w), preferably 12 to 40% (w / w), particularly preferably 15 to 30% (w / w), in particular 18 to 25% (w / w) of an abrasive; (b) 5 to 50% (w / w), preferably 10 to 45% (w / w), particularly preferably 15 to 40% (w / w), in particular 18 to 30% (w / w) of a moisturizer; (c) 0.005 to 10.0% (w / w), preferably 0.1 to 5.0% (w / w), more preferably 0.5 to 1.0% (w / w) of a flavoring agent, and (d) 0.01 to 10% (w / w), preferably 0.1 to 5% (w / w), more preferably 1.0 to 2.0% (w / w) of a functional additive 2. The oral care composition of claim 1, comprising: (Item 3) 3. The oral care composition according to item 2, wherein the abrasive is selected from silicon dioxide, for example silica gel, silicon dioxide hydrate or precipitated silicon dioxide; aluminum oxide; insoluble phosphates, calcium carbonate or combinations thereof. (Item 4) 4. The oral care composition of claim 2 or 3, wherein the humectant is selected from glycerol, sorbitol, xylitol, polyethylene glycol, or a combination thereof. (Item 5) 5. The oral care composition according to any one of items 2 to 4, wherein the flavoring agent is selected from a flavoring agent and / or a sweetener. (Item 6) 6. The oral care composition according to any one of items 2 to 5, wherein the functional additive is selected from a colorant, a corrosion inhibitor, an anti-caries agent, an anti-plaque agent, an anti-tartar agent, an anti-inflammatory agent, a deodorizing agent, a desensitizing agent, or a combination thereof. (Item 7) (a) 10 to 50% (w / w), preferably 12 to 40% (w / w), particularly preferably 15 to 30% (w / w), in particular 18 to 25% (w / w) of an abrasive; (b) 5 to 50% (w / w), preferably 10 to 45% (w / w), particularly preferably 15 to 40% (w / w), in particular 18 to 30% (w / w) of a moisturizer; (c) 2 to 20% (w / w), preferably 4 to 16% (w / w), particularly preferably 6 to 12% (w / w), in particular 8 to 10% (w / w) of cellulose; (d) 5 to 30% (w / w), preferably 8 to 26% (w / w), particularly preferably 12 to 22% (w / w), and particularly preferably 14 to 18% (w / w) of a lactic acid bacteria fermentation compound; (e) 1 to 12% (w / w), preferably 2 to 10% (w / w), particularly preferably 3 to 8% (w / w), and particularly preferably 4 to 6.0% (w / w) of starch 2. The oral care composition of claim 1, comprising: (Item 8) 8. The oral care composition according to any one of items 1 to 7, which does not contain a surfactant, and the surfactant comprises an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant. (Item 9) 9. The oral care composition according to any one of items 1 to 8, which is preservative-free. (Item 10) 10. The oral care composition according to any one of items 1 to 9, having a water activity of less than 0.75, preferably less than 0.65, in particular less than 0.6.

Claims

1. 1. A foamable oral care composition comprising methylcellulose, wherein the methylcellulose at a concentration of 0.1% by weight in an aqueous solution has a surface tension of less than 60 mN / m, the methylcellulose content in the composition is 2 to 5% by weight based on the weight of the composition, and the foamable oral care composition does not comprise a surfactant, with the proviso that the surfactant does not comprise an aqueous solution of methylcellulose, and the foamable oral care composition has a water activity of less than 0.

70.

2. (a) 10 to 50% (w / w) of an abrasive; (b) 5 to 50% (w / w) of a humectant; (c) 0.005 to 10.0% (w / w) of a flavoring agent, and (d) 0.01 to 10% (w / w) of a functional additive selected from a colorant, a corrosion inhibitor, an anti-caries agent, an anti-plaque agent, an anti-tartar agent, an anti-inflammatory agent, an anti-odor agent, a desensitizing agent, or a combination thereof.

10. The oral care composition of claim 1, comprising:

3. 3. The oral care composition of claim 2, wherein the abrasive is selected from silicon dioxide, aluminum oxide, insoluble phosphates, calcium carbonate, or combinations thereof.

4. 4. The oral care composition of claim 2 or 3, wherein the humectant is selected from glycerol, sorbitol, xylitol, polyethylene glycol, or combinations thereof.

5. An oral care composition according to any one of claims 2 to 4, wherein the flavouring agent is selected from flavours and / or sweeteners.

6. 6. The oral care composition of claim 2, wherein the functional additive is selected from a colorant, a corrosion inhibitor, an anti-caries agent, an anti-plaque agent, an anti-tartar agent, an anti-inflammatory agent, a deodorizing agent, or a desensitizing agent.

7. (a) 10 to 50% (w / w) of an abrasive; (b) 5 to 50% (w / w) of a humectant; (c) 2-20% (w / w) cellulose that is not methylcellulose; (d) 5 to 30% (w / w) of a lactic acid bacteria fermentation compound, and (e) 1 to 12% (w / w) starch 10. The oral care composition of claim 1, comprising:

8. An oral care composition described in any one of claims 1 to 7, wherein the content of methylcellulose in the composition is 2.5 to 4.0 weight % based on the weight of the composition.

9. An oral care composition as described in claim 3, wherein the silicon dioxide is silica gel, silicon dioxide hydrate or precipitated silicon dioxide.

10. An oral care composition described in any one of claims 1 to 9, having a water activity of less than 0.65.

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