Preventive and therapeutic agent for allergic dermatitis

Abstract

To provide a novel prevention / therapeutic agent of allergic dermatitis.SOLUTION: Technical features of the present invention in order to solve the above problem are as follows. 1. inhibitor of itching caused by immediate-type allergy which has lycoperosides and / or tomato seed extract as active ingredients. 2. the inhibitor of itching caused by immediate-type allergy described in 1 above in which the lycoperosides is lycoperoside H. 3. reaction inhibitor for immediate-type allergy which has lycoperoside H and / or tomato seed extract as active ingredients.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a preventive and therapeutic agent for allergic dermatitis, which can be widely used in foods, medicines, cosmetics, external skin preparations, etc. [Background technology]

[0002] Tomatoes (Solanum lycopersicum) are a plant commonly eaten worldwide and are sold as juice and supplements due to their rich content of vitamin C, lycopene, GABA, and other compounds. Tomatoes have been reported to have functions such as lowering blood pressure and cholesterol. Furthermore, in 2004, novel saponins called esculeosides were identified from tomatoes (Non-Patent Documents 1 and 2), and esculeoside A was found to have the effect of improving hyperlipidemia and arteriosclerosis in mice (Non-Patent Document 3). However, these findings are all based on tomato fruit, and there are few reports specifically focused on tomato seeds.

[0003] Furthermore, since dry skin is a typical symptom of allergic dermatitis, maintaining skin moisture content can help alleviate the symptoms of allergic dermatitis. Several moisturizing factors are active in the skin, representative of which are filaggrin and ceramide. These are known to be significantly reduced in the skin of people with atopic dermatitis, and it is thought that increasing the filaggrin and ceramide content in the skin can alleviate the dry skin symptom of allergic dermatitis.

[0004] The biosynthetic pathway of sphingolipids has been extensively studied. In the first step of sphingolipid synthesis, the non-essential amino acid L-serine and palmitoyl-CoA are used as starting materials. The enzyme serine palmitoyltransferase (SPT) condenses palmitoyl-CoA with the non-essential amino acid L-serine, resulting in the synthesis of ceramide in the spinous layer through four steps. This is then converted into sphingomyelin by sphingomyelin synthase, which accumulates in the granular layer. Subsequently, ceramide is again synthesized in the stratum corneum by acid sphingomyelinase (pathway on the right in Figure 6).

[0005] In addition, ceramide synthesized in the spinous layer is converted to glucosylceramide by glucosylceramide synthase and accumulates in the granular layer, and then ceramide is synthesized again in the stratum corneum by glucocerebrosidase (left pathway in Figure 6).

[0006] Furthermore, there are 10 types of ceramides (EOS, NS, NP, EOH, AS, AP, AH, NH, EOP), and it is said that a deficiency of ceramides (EOS), (NP), and (AP) in particular has a strong impact on dry skin, sensitive skin, and atopic dermatitis.

[0007] Here, ceramides (EOS, NS, EOH, AS, AP) are produced via the left pathway in Figure 6, which produces ceramides from glucosylceramide. In contrast, the right pathway, which produces ceramide from sphingomyelin, produces only ceramides (NS) and (AS). In particular, ceramide NP, which is involved in alleviating dry skin caused by allergic skin inflammation, etc., is produced only through the left pathway (Patent Document 1).

[0008] [Non-Patent Document 1] Fujiwara S. et al., Tetrahedron, 60, 4915-4920 (2004). [Non-patent document 2] Ono M. et al., Chem. Pharm. Bull., 54(2), 237-239 (2006). [Non-patent document 3] Nohara T., J. Trad. Med., 27, 217-224 (2010). [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-105741 DISCLOSURE OF THE INVENTION [Problem to be solved by the invention]

[0009] Under the above circumstances, the present inventors evaluated the effectiveness of tomato seed extract and lycoperosides against allergic dermatitis and found that they have the effect of improving allergic skin. They also found that tomato seed extract and lycoperosides have the effect of promoting filaggrin expression and moisturizing properties, and thus completed the present invention. That is, an object of the present invention is to provide a novel agent for preventing and treating allergic dermatitis. [Means for solving the problem]

[0010] The technical features of the present invention for solving the above problems are as follows. 1. An agent for suppressing itching caused by immediate-type allergies, containing lycoperosides and / or tomato seed extract as active ingredients. 2. The agent for suppressing itching caused by immediate-type allergy according to 1 above, wherein the lycoperoside is lycoperoside H. 3. An immediate-type allergic reaction suppressant containing lycoperoside H and / or tomato seed extract as active ingredients. 4. A moisturizer containing lycoperosides and / or tomato seed extract as active ingredients. 5. A filaggrin gene expression promoter containing lycoperosides and / or tomato seed extract as active ingredients. 6. A ceramide synthase-3 expression promoter containing lycoperosides and / or tomato seed extract as active ingredients. 7. The agent according to any one of items 4 to 6 above, wherein the lycoperoside is at least one of lycoperoside A and lycoperoside H. 8. A GCS gene expression promoter containing at least one of tomato seed extract, lycoperoside A, and lycoperoside H as an active ingredient. 9. A GBA gene expression promoter containing at least one of tomato seed extract, lycoperoside A, and lycoperoside H as an active ingredient. 10. An SMS gene expression inhibitor containing at least one of tomato seed extract and lycoperoside H as an active ingredient. 11. Ceramide NP production promoter containing lycoperoside H as the active ingredient. 12. A preventive and / or therapeutic agent for allergic dermatitis, comprising as an active ingredient any one of the agents described in 1. to 11. above. 13. A preventive and therapeutic agent for allergic dermatitis, the active ingredients of which are lycoperosides and / or tomato seed extract. [Effects of the Invention]

[0011] According to the present invention, lycoperosides, a saponin found only in tomato seeds and not in the pulp, and tomato seed extract have the effect of suppressing itching caused by immediate-type allergies, making these ingredients useful as agents for the prevention and treatment of allergic dermatitis. Furthermore, among the above lycoperosides, lycoperoside H is particularly advantageous in suppressing itching caused by immediate-type allergies. Furthermore, lycoperoside H and / or tomato seed extract have the effect of suppressing immediate-type allergies. In addition, lycoperosides and tomato seed extract have moisturizing effects, promote filaggrin gene expression, and promote ceramide synthase-3 expression, making them suitable for use as preventive and therapeutic agents for allergic dermatitis. Furthermore, lycoperosides and / or tomato seed extract not only suppress immediate-type allergies but also improve dermatitis caused by dry skin, making them useful as agents for improving dermatitis caused by dry skin. This promotes ceramide production in the pathway on the left in Figure 6, thereby promoting the production of ceramides EOS, NP, and AP, especially ceramide NP, which are said to have a particularly strong effect on preventing dry skin, sensitive skin, atopic dermatitis, etc. As described above, in the present invention, lycoperosides and tomato seed extract are useful as agents for preventing and treating allergic dermatitis. [Brief explanation of the drawings]

[0012] [Figure 1] 1 is a graph showing the effects of a tomato seed extract and lycoperoside H on a mouse pruritus model. [Figure 2] 1 is a graph showing the effects of tomato seed extract and lycoperoside H on mouse ear PCA reactions. [Figure 3] 1 is a graph showing the effects of tomato seed extract and lycoperosides on filaggrin gene expression. [Figure 4] 1 is a graph showing the effects of tomato seed extract and lycoperosides on ceramide synthase-3 (CerS3) gene expression. [Figure 5] 1 is a graph showing the effects of tomato seed extract and lycoperosides on TEWL. [Figure 6] 1 shows the effect of tomato seed extract on the stratum corneum ceramide synthesis pathway, with the white arrow indicating the effect of tomato seed extract. [Figure 7]1 is a graph showing the effects of tomato seed extract and lycoperosides on GCS gene expression. [Figure 8] 1 is a graph showing the effects of tomato seed extract and lycoperosides on GBA gene expression. [Figure 9] 1 is a graph showing the effects of tomato seed extract and lycoperosides on SMS gene expression. [Figure 10] 1 is a graph showing the effects of tomato seed extract and lycoperosides on ASM gene expression. [Figure 11] 1 is a graph showing the effects of tomato seed extract and lycoperosides on the amount of ceramide in the stratum corneum. BEST MODE FOR CARRYING OUT THE INVENTION

[0013] The present invention will be described in detail below. The preventive and therapeutic agent for allergic dermatitis of the present invention is characterized by containing lycoperosides as active ingredients. The lycoperosides are not particularly limited, but examples thereof include lycoperoside A and lycoperoside H. These may be used alone or in combination of two or more. Lycoperoside A is a saponin represented by the following chemical formula (1). [ka] Lycoperoside H is a saponin represented by the following chemical formula (2). [ka]

[0014] The method for obtaining lycoperoside A and lycoperoside H is not particularly limited, but a method of extracting and purifying them from plants is particularly preferred. When lycoperoside A and lycoperoside H are extracted from plants, the raw material is not particularly limited, but it is particularly preferable to use tomatoes, as they contain high concentrations of lycoperoside A and lycoperoside H. Furthermore, when extracting lycoperoside A and lycoperoside H from tomatoes, tomato seeds are used because lycoperoside A and lycoperoside H are not found in the flesh or skin of tomatoes, but only in the seeds.

[0015] Furthermore, when solvent extraction is used as the extraction method, examples of extraction solvents to obtain the extract include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, 1,3-butylene glycol, etc.), lower esters (ethyl acetate, etc.), hydrocarbons (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether, etc.), acetonitrile, etc., and one or more of these can be used.

[0016] A preferred example of the extraction method is a method in which extraction is carried out using aqueous ethanol or aqueous methanol at a concentration of 0 to 100% (v / v) at room temperature or with heating for 1 to 10 hours, followed by filtration.

[0017] As a purification method, the tomato seed extract obtained by the above method can be subjected to sequential partition extraction with ethyl acetate and n-butanol, followed by silica gel chromatography, column chromatography, etc. to obtain lycoperoside A and lycoperoside H.

[0018] As a specific method for obtaining lycoperoside A and lycoperoside H from tomato seeds, the method according to the Examples of this specification is preferred.

[0019] The preventive and therapeutic agent for allergic dermatitis of the present invention can be used as an ingredient in various food and beverage compositions. Examples of foods and beverages include general foods such as confectioneries (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummy candy, tablet candy, etc.), noodles (soba, udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, black tea, green tea, carbonated drinks, sports drinks, etc.), as well as health foods (tablets, capsules, etc.), nutritional supplements (nutrition drinks, etc.), functional foods, and foods for specified health uses. The preventive and therapeutic agent for allergic dermatitis of the present invention can be appropriately blended into these foods and beverages.

[0020] These food and beverage compositions can contain various ingredients depending on their type, and food ingredients such as glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters, gum arabic, carrageenan, casein, gelatin, pectin, agar, B vitamins, nicotinamide, calcium pantothenate, amino acids, calcium salts, colorants, flavorings, and preservatives can be used.

[0021] As a specific manufacturing method, the preventive and therapeutic agent for allergic dermatitis can be spray-dried or freeze-dried together with powdered cellulose, and then formed into a powder, granules, tablets, or solution, which can be easily incorporated into foods and beverages (instant foods, etc.). The preventive and therapeutic agent for allergic dermatitis can also be dissolved in, for example, oils and fats, ethanol, glycerin, or a mixture thereof to form a liquid, which can then be added to beverages or solid foods. If necessary, it can also be mixed with a binder such as gum arabic or dextrin to form a powder or granules, which can then be added to beverages or solid foods.

[0022] When the preventive and therapeutic agent for allergic dermatitis of the present invention is applied to food and drink, the amount of the active ingredient added is preferably 1 to 20 wt% in total relative to the food and drink, since the main purpose is to maintain health and beauty.

[0023] The agent for preventing and treating allergic dermatitis of the present invention may be used as a material for pharmaceutical compositions (including pharmaceuticals and quasi-drugs). Pharmaceutical compositions can be produced by appropriately blending the agent for preventing and treating allergic dermatitis of the present invention with raw materials for pharmaceutical formulations. Examples of pharmaceutical raw materials that can be blended into the agent for preventing and treating allergic dermatitis of the present invention include excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hardened vegetable oil, kaolin, talc, etc.), binders (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrants (sodium alginate, agar), and the like. , sodium bicarbonate, calcium carbonate, sodium lauryl sulfate, stearate monoglyceride, starch, lactose, gum arabic, gelatin, ethanol, etc.), disintegration inhibitors (white sugar, stearin, cocoa butter, hydrogenated oil, etc.), absorption enhancers (quaternary ammonium bases, sodium lauryl sulfate, etc.), adsorbents (glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearates, polyethylene glycol, etc.).

[0024] The agent for preventing and treating allergic dermatitis of the present invention can generally be administered orally in the form of tablets, pills, soft or hard capsules, fine granules, powders, granules, liquids, etc., but may also be administered parenterally. When administered parenterally, the agent may be administered in the form of a solution or with the addition of a dispersant, suspending agent, stabilizer, etc., by local tissue administration, intradermal, subcutaneous, intramuscular, or intravenous injection. It may also be in the form of a suppository, etc.

[0025] The dosage may vary depending on the administration method, the condition, the age of the patient, etc., but typically, adults can be given 0.5 to 5000 mg of the active ingredient per day, and children can be given 0.5 to 3000 mg. The compounding ratio of the preventive and therapeutic agent for allergic dermatitis can be changed as appropriate depending on the dosage form, but it is usually about 0.3 to 15.0 wt% when administered orally or via mucosal absorption, and about 0.01 to 10 wt% when administered parenterally. Note that the dosage varies depending on various conditions, so in some cases a smaller dosage than the above is sufficient, and in other cases it may be necessary to administer more than the above range.

[0026] The agent for preventing and treating allergic dermatitis of the present invention can be expected to have an action as an agent for preventing and treating allergic dermatitis even when used as an external agent for skin (including cosmetics, medicines and quasi-drugs). Examples of the forms of external skin preparations that can be blended with the agent for preventing and treating allergic dermatitis of the present invention include emulsions, soaps, facial cleansers, bath additives, creams, emulsions, lotions, colognes, shaving creams, shaving lotions, cosmetic oils, suntan / sunscreen lotions, face powders, foundations, perfumes, packs, nail creams, enamel, enamel removers, eyebrow pencils, blushers, eye creams, eye shadows, mascara, eyeliners, lipsticks, lip balms, shampoos, rinses, hair dyes, dispersions, cleansers, etc. Examples of the forms of pharmaceuticals or quasi-drugs that can be blended with the agent for preventing and treating allergic dermatitis of the present invention include ointments, creams, external liquids, etc.

[0027] In addition to the agent for preventing and treating allergic dermatitis according to the present invention, the topical skin preparations in the above forms can contain ingredients that are incorporated into topical skin preparations such as cosmetics and quasi-drugs, as long as the ingredients do not impair the activity of the agent for preventing and treating allergic dermatitis, such as oils, higher alcohols, fatty acids, ultraviolet absorbers, powders, pigments, surfactants, polyhydric alcohols, sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. Examples are listed below, but the present invention is not limited to these examples.

[0028] (1) Examples of oil Ester-based oil phase ingredients: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, diisopropyl adipate Isopropyl, Isoarachyl Neopentanoate, Caprylic / Capric Triglyceride, Trimethylolpropane Tri-2-Ethylhexanoate, Trimethylolpropane Triisostearate, Pentaerythritol Tetra-2-Ethylhexanoate, Cetyl Caprylate, Decyl Laurate, Hexyl Laurate, Decyl Myristate, Myristyl Myristate, Cetyl Myristate, Stearyl Stearate, Decyl Oleate, Cetyl Ricinoleate, Isostearyl Laurate, Isotridecyl Myristate, Isocetyl Myristate, Isostearate Myristate Tearyl, Isocetyl Palmitate, Isostearyl Palmitate, Octyl Stearate, Isocetyl Stearate, Isodecyl Oleate, Octyldodecyl Oleate, Octyldodecyl Linoleate, Isopropyl Isostearate, Cetostearyl 2-Ethylhexanoate, Stearyl 2-Ethylhexanoate, Hexyl Isostearate, Ethylene Glycol Dioctanoate, Ethylene Glycol Dioleate, Propylene Glycol Dicaprate, Propylene Glycol Dicaprylate, Propylene Glycol Dicaprylate, Dicaprin Neopentyl glycol acid, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, polyglycerin isostearate, dipropyl carbonate,Dialkyl carbonate (C12-18), triisocetyl citrate, triisoarachidyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate propyl, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, stearyl 12-stearoylhydroxystearate, isostearyl 12-stearoylhydroxystearate, etc. Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum, etc. Animal and vegetable oils and their hydrogenated oils, and naturally derived waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated lard, horse oil, hydrogenated horse oil, mink oil, orange roughy oil, fish oil, hydrogenated fish oil, egg yolk oil, and other animal oils and their hydrogenated oils, avocado oil, almond oil, olive oil, cocoa butter, kiwi seed oil, apricot kernel oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil, perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, Examples of suitable oils include vegetable oils and their hydrogenated oils such as hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil, sunflower oil, grape seed oil, jojoba oil, hydrogenated jojoba oil, macadamia nut oil, medlar oil, cottonseed oil, hydrogenated cottonseed oil, coconut oil, and hydrogenated coconut oil; and waxes such as beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax, and montan wax. Silicone-based oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethylsiloxane-methylcetyloxysiloxane copolymer, dimethylsiloxane-methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber, etc. Fluorine-based oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl-polyoxyalkylene co-modified organopolysiloxane, etc.

[0029] (2) Examples of higher alcohols Examples include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, and octyldodecanol.

[0030] (3) Examples of fatty acids Examples of the acid include caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid, erucic acid, and 2-ethylhexanoic acid.

[0031] (4) Examples of UV absorbers Para-aminobenzoic acid, amyl para-aminobenzoate, ethyl dihydroxypropyl para-aminobenzoate, glyceryl para-aminobenzoate, ethyl para-aminobenzoate, octyl para-aminobenzoate, octyldimethyl para-aminobenzoate, ethylene glycol salicylate, octyl salicylate, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl para-methoxycinnamate, 2-ethylhexyl para-methoxycinnamate, glyceryl di-para-methoxycinnamate mono-2-ethylhexanoate, isopropyl para-methoxycinnamate, diethanolamine para-methoxyhydrocinnamate, diisopropyl and diisopropyl cinnamate mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, di Examples of the hydroxymethoxybenzophenone include sodium dihydroxymethoxybenzophenone disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, butylmethoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2-ethylhexyl-1-oxy)-1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, phenylbenzimidazole sulfate, 3-(4-methylbenzylidene)camphor, isopropyldibenzoylmethane, 2-ethylhexyl 4-(3,4-dimethoxyphenylmethylene)-2,5-dioxo-1-imidazolidinepropionate, and polymer derivatives and silane derivatives thereof.

[0032] (5) Examples of powders and pigments Dyes such as Red No. 104, Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, lake dyes such as Yellow No. 4 AL Lake and Yellow No. 203 BA Lake, nylon powder, silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, black iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and iron blue, zinc oxide, titanium oxide, acid Examples of suitable powders include white pigments such as cerium chloride, extender pigments such as talc, mica, sericite, kaolin, and plate-like barium sulfate, pearl pigments such as titanium dioxide, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, and magnesium silicate, inorganic powders such as silica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, and zinc undecylenate, bentonite, smectite, and boron nitride. There are no particular limitations on the shape (spherical, rod-like, needle-like, plate-like, irregular, flaky, spindle-like, etc.) and particle size of these powders. These powders may or may not have been previously surface-treated by conventionally known surface treatments, such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil treatment, N-acylated lysine treatment, polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, etc.

[0033] (6) Examples of surfactants Anionic surfactants: fatty acid soaps, α-acylsulfonates, alkylsulfonates, alkylarylsulfonates, alkylnaphthalenesulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkyl phosphates, alkylamide phosphates, alkyloylalkyl taurine salts, N-acylamino acid salts, POE alkyl ether carboxylates, alkyl sulfosuccinates, sodium alkylsulfoacetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, etc. Cationic surfactants: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride, behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, etc. Amphoteric surfactants: Examples thereof include carboxybetaine type, amidobetaine type, sulfobetaine type, hydroxysulfobetaine type, amidosulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, and amidoamine type. Nonionic surfactants: Propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE glycerin fatty acid esters, POE alkyl ethers, POE fatty acid esters, POE hydrogenated castor oil, POE castor oil, POE-POP copolymers, POE-POP alkyl ethers, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipids, etc. Natural surfactants: Examples include lecithin, saponin, sugar-based surfactants, etc.

[0034] (7) Examples of polyhydric alcohols and sugars Examples of suitable sugars include ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1,3-butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugars, sulfated trehalose, pullulan, etc. Chemically modified versions of these sugars may also be used.

[0035] (8) Examples of polymers Acrylate / methacrylate copolymer (Plussize, manufactured by GOO Chemical Co., Ltd.), vinyl acetate / crotonic acid copolymer (Resin 28-1310, manufactured by NSC), vinyl acetate / crotonic acid / vinyl neodecanoate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), t-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (Ruvimer, manufactured by BASF), vinylpyrrolidone / vinyl acetate / vinyl propionate copolymer (Ruviscol VAP, manufactured by BASF), vinyl acetate Vinyl acetate / crotonic acid copolymer (Rubyset CA, BASF), vinyl acetate / crotonic acid / vinyl pyrrolidone copolymer (Rubyset CAP, BASF), vinyl pyrrolidone / acrylate copolymer (Rubyflex, BASF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxyvinyl polymer (Carbopol, BFGoodrich), acrylic acid / alkyl methacrylate copolymer (Pemulen, BF Examples of such polymers include anionic polymers such as acetic acid amphoteric dialkylaminoethyl methacrylate polymer (Yukaformer, manufactured by Mitsubishi Chemical Corporation) and amphoteric polymers such as octylacrylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, manufactured by NSC Corporation); cationic polymers such as quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, manufactured by ISP Corporation) and methylvinylimidazolium chloride / vinylpyrrolidone copolymer (Rubycoat, manufactured by BASF Corporation); and nonionic polymers such as polyvinylpyrrolidone (Ruviscol K, manufactured by BASF Corporation), vinylpyrrolidone / vinyl acetate copolymer (Ruviscol VA, manufactured by BASF Corporation), vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (Copolymer 937, manufactured by ISP Corporation), and vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (Copolymer VC713, manufactured by ISP Corporation).Also suitable for use are naturally occurring polymeric compounds such as cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharides, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, gellan gum, and dextran.

[0036] (9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some kind of physiological activity to the skin when applied to the skin. Examples include whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair restoration agents, moisturizers, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation relievers, analgesics, cell activators, enzyme components, etc. Examples of suitable ingredients include angelica extract, avocado extract, hydrangea extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, fennel extract, turmeric extract, oolong tea extract, angelica tree extract, echinacea leaf extract, Scutellaria root extract, Phellodendron bark extract, Coptis japonica extract, barley extract, St. John's wort extract, white nettle extract, watercress extract, orange extract, Dried seawater, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, artemisia capillaris extract, licorice extract, kalk extract, kakyoku extract, cinchona extract, cucumber extract, guanosine, gardenia extract, kumazasa extract, sophora flavescens extract, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, black tea extract, yeast extract, burdock extract, Fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, Chinese radish extract, Bupleurum extract, umbilical cord extract, salvia extract, soapwort extract, bamboo extract, hawthorn extract, Japanese pepper extract, shiitake mushroom extract, rehmannia root extract, Lithospermum root extract, perilla extract, linden extract, meadowsweet extract, peony extract, calamus root extract, white birch extract, horsetail extract, ivy extract, hawthorn extract, se Sambucus extract, yarrow extract, peppermint extract, sage extract, mallow extract, cnidium extract, Swertia japonica extract, soybean extract, Chinese laurel extract, thyme extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract,Examples of such extracts include burdock root extract, parsley extract, honey, witch hazel extract, parietaria extract, burdock root extract, bisabolol, loquat extract, coltsfoot extract, butterbur stalk extract, poria cocos extract, butcher's broom extract, grape extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, coix seed extract, mugwort extract, lavender extract, apple extract, lettuce extract, lemon extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, and royal jelly extract. In addition, it contains biopolymers such as deoxyribonucleic acid, mucopolysaccharides, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, and hydrolyzed eggshell membrane, moisturizing ingredients such as amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, whey, and trimethylglycine, oily ingredients such as sphingolipids, ceramides, phytosphingosine, cholesterol, cholesterol derivatives, and phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, and guaiazulene. Immune stimulants such as methicone and hydrocortisone, vitamins such as vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoids, flavonoids, tannins, lignans, saponins, cell activators such as alpha-hydroxy acids and beta-hydroxy acids, blood circulation promoters such as gamma-oryzanol and vitamin E derivatives, Wound healing agents such as retinol and retinol derivatives, skin whitening agents such as arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, and glutathione, cepharanthine, licorice extract, capsicum tincture, hinokitiol, iodized garlic extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivatives, calcium pantothenate, D-pantothenyl alcohol, acetylpantothenyl ethyl ether, biotin, allantoin, isopropyl methylphenol, estradiol Alcohol, ethinylestradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, tacanal, camphor, salicylic acid, nonylic acid vanillylamide, nonanoic acid vanillylamide, piroctone olamine, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcinol, gamma-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormones, cantharides tincture, cyclosporine, zinc pyrithione, hydrocholorthisone, minoxidil, polyoxyethylene sorbitan monostearate, peppermint oil,Examples include hair growth agents such as Sasanishiki extract.

[0037] (10) Examples of antioxidants Examples of antioxidants include sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolylbiguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxytoluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoids, flavonoids, tannins, lignans, saponin, and plant extracts known to have antioxidant effects, such as apple extract and clove extract.

[0038] (11) Examples of solvents Examples include purified water, ethanol, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, volatile linear silicones, and next-generation chlorofluorocarbons.

[0039] The agent for preventing and treating allergic dermatitis of the present invention can be used as a raw material for food and drink compositions, pharmaceutical compositions, and external skin preparations. The pharmaceutical raw materials that can be blended into these can be the same as those used in the above-mentioned preventive and therapeutic agents for allergic dermatitis, and the manufacturing methods and administration methods can also be the same as those for the preventive and therapeutic agents for allergic dermatitis. [Example]

[0040] The present invention will be described below based on examples. Example 1: Preparation of tomato seed extract, and isolation and identification of saponin components from tomato seeds 367.7 g of dried tomato seeds were extracted with methanol (70°C, 2 hours) to obtain a methanol extract. The resulting methanol extract was dispersed in water and sequentially partitioned with ethyl acetate and n-butanol to obtain 0.63 g of an ethyl acetate-soluble fraction (ethyl acetate fraction), 2.41 g of an n-butanol-soluble fraction (butanol fraction), and 5.05 g of a water-soluble fraction (water fraction). The butanol fraction was used as the tomato seed extract of this example. The butanol fraction was then subjected to silica gel chromatography (chloroform:methanol = 9:1 → 7:3 → chloroform:methanol:water = 6:4:1 → methanol) to obtain Fractions 1 to 6. Fraction 3 (1.1 g) was subjected to reverse-phase ODS column chromatography (methanol concentrations 20% → 50% → 80% → 100%) to obtain Fractions 3-1 to 3-4. The saponin compounds lycoperoside A (chemical formula (1) above) (7.0 mg) and H (chemical formula (2) above) (7.5 mg) were isolated from Fraction 3-3 (mg) by reverse-phase HPLC (Inertsil ODS-SP, 70% methanol). Each compound was identified by comparing its 1H-NMR (600 MHz) and 13C-NMR (150 MHz) spectra with literature values.

[0041] Test Example 1. Effect on a mouse pruritus model ddY mice were orally administered tomato seed extract (500 mg / kg) or lycoperoside H (10 or 30 mg / kg). One hour later, 50 μL of a 3% saline solution of compound 48 / 80 was administered subcutaneously to the back of the neck to induce scratching behavior in response to immediate allergic itch. After the first scratch, the mice were observed for 30 minutes and the number of scratches was counted. Diphenhydramine hydrochloride (30 mg / kg) was used as a positive control. The results are shown in Figure 1.

[0042] Results and Effects of Examples in Test Example 1 As a result of the experiment, it was confirmed that administration of tomato seed extract reduced the number of scratching episodes compared to the control group, as shown in Figure 1. It was also confirmed that administration of lycoperoside H also reduced the number of scratching episodes in a concentration-dependent manner. This confirmed that lycoperoside H and tomato seed extract are effective as agents for suppressing itching caused by allergies.

[0043] Test Example 2. Evaluation by mouse ear PCA response Anti-DNP-IgE diluted 2000-fold with saline was administered intradermally to both ears of ddY mice for sensitization. Two days later, tomato seed extract (500 mg / kg) or lycoperoside H (10 or 30 mg / kg) was administered orally. Two hours later, 0.25 mL of a saline solution containing 0.25 mg of DNP-BSA and 0.5% Evans blue was administered via the tail vein to induce an antigen-antibody reaction. After 0 minutes, the mice were sacrificed by cervical dislocation, and both ears were excised. The dye that had leaked into the ears was extracted and its absorbance at 620 nm was measured. The results are shown in Figure 2.

[0044] Results and Effects of Examples in Test Example 2 The results of the experiment confirmed that the amount of pigment leakage was significantly suppressed in the tomato seed extract (500 mg / kg) and lycoperoside H (10 mg / kg) administration groups (Figure 2). These results demonstrate that tomato seed extract and lycoperoside H have an inhibitory effect on immediate-type allergic reactions.

[0045] Test Example 3. Moisturizing effect in a 3D human epidermis model Tomato seed extract, lycoperoside H, or lycoperoside A was added to the membrane side of human epidermal 3D cells. 48 hours later, RNA was extracted from the collected tissue, and real-time RT-PCR was used to analyze the mRNA expression of the filaggrin gene and ceramide synthase-3 (CerS3), a gene involved in ceramide synthesis. The results are shown in Figure 3 (filaggrin gene) and Figure 4 (CerS3). TEWL was also measured over time from 24 to 72 hours of culture. The results are shown in Figure 5. In Figure 5, "TSE" stands for tomato seed extract, "LycoA" stands for lycoperoside A, and "LycoH" stands for lycoperoside H.

[0046] Results and Effects of Examples in Test Example 3 Real-time RT-PCR showed that the expression of filaggrin was significantly increased by the addition of tomato seed extract (10 μg / mL), lycoperoside H (3 and 10 μM), and lycoperoside A (1 μM) (Figure 3). On the other hand, the expression of ceramide synthase-3 (CerS3), an enzyme involved in ceramide synthesis, was significantly increased by the addition of tomato seed extract (1 and 3 μg / mL) and lycoperoside H (1, 3, and 10 μM) (Figure 4). Furthermore, TEWL measurements showed that after 72 hours of incubation, TEWL was significantly decreased in the tomato seed extract (10 μg / mL), lycoperoside H (10 μM), and lycoperoside A (10 μM)-treated groups compared with the control group (Figure 5). These results suggest that tomato seed extract and lycoperosides increase the skin's moisture-retaining capacity by increasing the expression of skin moisturizing factors.

[0047] Test Example 4. Evaluation of ceramide-related gene expression in a 3D human epidermis model Tomato seed extract, lycoperoside A, or lycoperoside H was added to the membrane side of human epidermal 3D cells, and RNA was extracted from the tissue collected 48 hours later. Real-time RT-PCR was used to analyze the mRNA expression of genes involved in ceramide synthesis (CerS, GCS, GBA, SMS, and ASM). After 7 days of culture, lipids were extracted from the stratum corneum isolated from the tissue, and ceramides were quantified by thin-layer chromatography (HPTLC). The results are shown in Figure 7 (GCS), Figure 8 (GBA), Figure 9 (SMS), Figure 10 (ASM), and Figure 11 (stratum corneum ceramide levels).

[0048] Results and Effects of Examples in Test Example 4 Real-time RT-PCR showed that the gene expression of glucosylceramide synthase (GCS) was significantly increased by the addition of tomato seed extract (3 μg / mL), lycoperoside A (3 μM), and lycoperoside H (3 and 10 μM) (Fig. 7). The gene expression of β-glucocerebrosidase (GBA) was also significantly increased by the addition of tomato seed extract (3 and 10 μg / mL), lycoperoside A (3 and 10 μM), and lycoperoside H (10 μM) (Fig. 8). On the other hand, the gene expression of tomato seed bolting phingomyelin synthase (SMS) was significantly decreased by the addition of tomato seed extract (10 μg / mL) and lycoperoside H (1, 3, and 10 μM) (Fig. 9). No significant effect of tomato seed extract, lycoperoside A, or lycoperoside H on the gene expression of acid sphingomyelinase (ASM) was observed (Figure 10). This confirmed that they promote ceramide production via the left pathway in Figure 6. Furthermore, quantification of stratum corneum ceramides by HPTLC confirmed that, among the stratum corneum ceramide species, ceramide NP significantly increased with the addition of lycoperoside H (1 and 10 μM) (Figure 11). Although no significant effects were observed for other ceramide species, they tended to increase with the addition of tomato seed extract, lycoperoside A, and lycoperoside H.

[0049] Effects of the Example Tomato seed extract and lycoperosides were found to have inhibitory effects on immediate allergic reactions and to alleviate dry skin, confirming their effectiveness as preventive and therapeutic agents for allergic dermatitis.

[0050] Examples of formulations of the preventive and therapeutic agent for allergic dermatitis (tomato seed extract or lycoperosides) of the present invention are given below, but the present invention is not limited to these formulation examples. Formulation example 1: Chewing gum Sugar 52.0wt% Gum base 20.0 Glucose 10.0 Starch syrup 16.0 Fragrance 0.5 Cherry blossom extract 0.5 Glucosylceramide 0.5 Allergic dermatitis prevention and treatment agent 0.5 100.0wt%

[0051] Mixing example 2: Gummies Reduced starch syrup 38.0wt% Granulated sugar 20.0 Glucose 20.0 Gelatin 4.7 Wednesday 9.68 Kiwi juice 4.0 Kiwi flavor 0.6 Dye 0.02 Cherry Blossom Extract 1.0 Glucosylceramide 1.0 Allergic dermatitis prevention and treatment agent 1.0 100.0wt%

[0052] Mixing example 3: Candy Sugar 50.0wt% Starch syrup 33.0 water 14.2 organic acid 2.0 Fragrance 0.2 Cherry blossom extract 0.1 Glucosylceramide 0.1 Allergic dermatitis prevention and treatment agent 0.4 100.0wt%

[0053] Blending example 4: Yogurt (hard / soft) Milk 41.5wt% Skim milk powder 5.8 Sugar 8.0 Agar 0.15 Gelatin 0.1 Lactic acid bacteria 0.005 Cherry blossom extract 0.1 Glucosylceramide 0.1 Allergic dermatitis prevention and treatment agent 0.4 fragrance trace amount water residue 100.0wt%

[0054] Formulation example 5: Soft drink High fructose corn syrup 30.0wt% Emulsifier 0.5 Strawberry Seed Extract 0.05 Glucosylceramide 0.05 Allergic dermatitis prevention and treatment agent 0.05 Fragrance (appropriate amount) Purified water remainder 100.0wt%

[0055] Formulation example 6: Soft capsule Rice germ oil 86.0wt% Cherry blossom extract 0.5 Glucosylceramide 0.5 Emulsifier 12.0 Allergic dermatitis prevention and treatment agent 1.0 100.0wt%

[0056] Formulation example 7: Tablets Lactose 53.0wt% Microcrystalline cellulose 30.0 Starch decomposition product 10.0 Cherry blossom extract 0.5 Glucosylceramide 0.5 Glycerin fatty acid ester 5.0 Allergic dermatitis prevention and treatment agent 1.0 100.0wt%

[0057] Formulation example 8: Granules for oral administration (medicine) Allergic dermatitis prevention and treatment agent 1.0wt% Strawberry Seed Extract 0.5 Glucosylceramide 0.5 Lactose 30.0 Cornstarch 60.0 Microcrystalline cellulose 7.0 Polyvinylpyrrolidone 1.0 100.0wt%

[0058] Formulation example 9: Tablet confectionery Sugar 75.4wt% Glucose 19.0 Sucrose fatty acid ester 0.2 Strawberry Seed Extract 0.5 Glucosylceramide 0.5 Allergic dermatitis prevention and treatment agent 0.5 Purified water 3.9 100.0wt%

[0059] Example 10: Cat food Corn 33.0wt% Wheat flour 35.0 Meat Meal 15.0 Beef tallow 8.9 Salt 1.0 Bonito extract 4.0 Strawberry Seed Extract 0.5 Glucosylceramide 0.5 Allergic dermatitis prevention and treatment agent 1.0 Taurine 0.1 Vitamins 0.5 Minerals 0.5 100.0wt%

[0060] Example 11: Dog food Corn 30.0wt% Meat (chicken) 15.0 Defatted soybeans 10.0 Wheat flour 24.0 Bran 5.0 Cherry blossom extract 0.5 Glucosylceramide 0.5 Allergic dermatitis prevention and treatment agent 5.0 Animal fats and oils 8.9 Oligosaccharides 0.1 Vitamin 0.5 Minerals 0.5 100.0wt%

[0061] Formulation example 12: Cosmetic cream Squalane 20.0wt% Beeswax 5.0 Refined Jojoba Oil 5.0 Glycerin 5.0 Glycerin Monostearate 2.0 Polyoxyethylene (20) sorbitan Monostearate 2.0 Allergic dermatitis prevention and treatment 2.0 Preservatives (appropriate amount) Fragrance (appropriate amount) Purified water remainder 100.0wt%

[0062] Formulation example 13: Lotion Ethanol 5.0wt% Glycerin 2.0 1,3-butylene glycol 2.0 Polyethylene oleyl ether 0.5 Sodium citrate 0.1 Citric acid 0.1 Allergic dermatitis prevention and treatment agent 0.1 Purified water remainder 100.0wt%

[0063] Formulation example 14: Body gel Macadamia nut oil 2.0wt% Octyldodecyl myristate 10.0 Methylphenylpolysiloxane 5.0 Behenyl Alcohol 3.0 Stearic Acid 3.0 Batyl alcohol 1.0 Glyceryl Monostearate 1.0 Polyoxyethylene sorbitol tetraoleate 2.0 Hydrogenated soybean phospholipid 1.0 Ceramide 0.1 Retinol Palmitate 0.1 Preservatives (appropriate amount) Centella asiatica extract 1.0 Allergic dermatitis prevention and treatment agent 1.0 1,3-butylene glycol 5.0 Purified water remainder 100.0wt%

[0064] Formulation example 15: Emulsion Squalane 4.0wt% Vaseline 2.5 Cetyl alcohol 2.0 Glycerin 2.0 Lipophilic Glyceryl Monostearate 1.0 Stearic Acid 1.0 L-Arginine 1.0 Allergic dermatitis prevention and treatment agent 0.5 Potassium hydroxide 0.1 fragrance trace amount Purified water remainder 100.0wt%

[0065] Formulation example 16: Bath additive (liquid) Propylene glycol 50.0wt% Ethanol 20.0 Sodium sulfate 5.0 Allergic dermatitis prevention and treatment agent 0.5 Lanolin 0.5 Avocado oil 0.5 Dye 1.5 Fragrance 22.0 100.0wt% [Industrial Applicability]

[0066] As explained above, the present invention can provide a novel agent for preventing and treating allergic dermatitis.

Claims

[Claim 1] A moisturizer for dry skin caused by allergic dermatitis symptoms, containing at least one active ingredient selected from lycoperoside A, lycoperoside H and tomato seed extract.

Images