Disinfecting and cleaning composition, its manufacturing method, and sterilizing and cleaning method using the same

Abstract

A disinfecting and cleaning composition comprising 0.001 to 30% by mass of peracetic acid, 0.001 to 30% by mass of hydrogen peroxide, 1 to 70% by mass of acetic acid and / or a salt thereof, 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, wherein the pH of the composition is 4.0 to 10.0.

Description

[Technical Field]

[0001] The present invention relates to a sterilizing and cleaning composition that is particularly suitable for sterilizing and cleaning medical instruments. [Background technology]

[0002] Conventionally, aqueous peracid solutions have been widely used for sterilizing and cleaning medical instruments (Patent Documents 1 to 4). However, conventional aqueous peracid solutions are not necessarily satisfactory in terms of stability, bactericidal properties, and scale removal ability.

[0003] Traditionally, acidic and alkaline chemicals have been used to sterilize and clean medical equipment, including aqueous solutions of peracid. However, the use of acidic and alkaline chemicals has led to numerous cases of wastewater being discharged without meeting sewage discharge standards, damaging concrete sewer pipes. Damage to sewer pipes not only prevents water from being discharged into the sewer system but also potentially causes road collapses, requiring immediate action. Against this backdrop, the Tokyo Metropolitan Government Bureau of Sewerage issued a warning regarding dialysis wastewater and sewer pipes in January 2019. The Bureau requires that the sewage discharge standard for wastewater be within a hydrogen ion concentration (pH) range of more than 5 and less than 9.

[0004] Known peracetic acid compositions for sterilization and cleaning of medical equipment include an acidic aqueous solution of peracetic acid (Patent Document 5), an acidic oxidizing agent-containing composition that inhibits aluminum corrosion (Patent Document 6), and an alkaline disinfectant and cleaning formulation (Patent Document 7). However, these compositions do not necessarily meet the sewage discharge standards for wastewater. Therefore, there is still a need for cleaners that do not damage drainage pipes. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Special Publication No. 2007-507599 [Patent Document 2] Special Publication No. 2013-505929 [Patent Document 3] Japanese Patent Application Laid-Open No. 2015-40209 [Patent Document 4] Japanese Patent Application Laid-Open No. 2016-17056 [Patent Document 5] Japanese Patent Application Laid-Open No. 2010-184868 [Patent Document 6] WO2010 / 095231 publication [Patent Document 7] Special Publication No. 2016-532634 Summary of the Invention [Problem to be solved by the invention]

[0006] There is a need for a sterilizing and cleaning composition that has improved stability, sterilizing properties, and descaling ability. There is also a need for a medical device sterilizing and cleaning composition that has high peroxide stability and whose wastewater meets sewage discharge standards. [Means for solving the problem]

[0007] As a result of extensive research, the present inventors have discovered that by adding a special anionic surfactant (polyoxyethylene lauryl ether acetic acid) to peracetic acid, it is possible to provide a sterilizing and cleaning composition that has improved stability and bactericidal properties compared to conventional aqueous peracetic acid solutions and that also has scale removal ability.The present inventors have also discovered that by adding a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, it is possible to provide a medical device sterilizing and cleaning composition that has high peroxide stability and whose wastewater meets sewage discharge standards.

[0008] That is, the present invention includes the following embodiments.

[0009] <1> A disinfecting and cleaning composition comprising 0.001 to 30% by mass of peracetic acid, 0.001 to 30% by mass of hydrogen peroxide, 1 to 70% by mass of acetic acid and / or a salt thereof, 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, A disinfecting and cleaning composition, the pH value of which is 4.0 to 10.0. <2> Further containing a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive. <1> The composition described in <3> The phosphorus-based stabilizer and / or carboxylic acid-based stabilizer are contained in an amount of 0.0001 to 5% by mass. <2> The composition described in <4> The aforementioned Phosphorus stabilizer is selected from the group consisting of pyrophosphoric acid or a salt thereof, phosphoric acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, nitrilotrismethylenephosphonic acid or a salt thereof, 2-phosphonobutane-1,2,4-tricarboxylic acid or a salt thereof, and ethylenediaminetetramethylenephosphonic acid or a salt thereof, and is preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof; <2> or <3> The composition described in <5> the carboxylic acid stabilizer comprises any one of ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethylenetriaminepentaacetic acid (DTPA) or a salt thereof, picolinic acid or a salt thereof, dipicolinic acid or a salt thereof, nitrilotriacetic acid or a salt thereof, N-(2-hydroxyethyl)ethylenediamine-N,N',N"-triacetic acid or a salt thereof, triethylenetetramine-N,N,N',N",N"',N"'-hexaacetic acid or a salt thereof, 1,3-propanediamine-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-propanol-N,N,N',N'-tetraacetic acid, N-(2-hydroxyethyl)iminodiacetic acid or a salt thereof, N,N-di(2-hydroxyethyl)glycine or a salt thereof, glycol ether diaminetetraacetic acid, and (S,S)-ethylenediamine-N,N'-disuccinic acid or a salt thereof, and is preferably ethylenediaminetetraacetic acid (EDTA) or a salt thereof; <2> or <3> The composition according to any one of the preceding claims.

[0010] <6> <1> ~ <5> a composition according to any one of the preceding claims, additional water A diluted disinfecting and cleaning composition comprising: <7> containing 0.001 to 1.5 mass% of peracetic acid, 0.001 to 2.5 mass% of hydrogen peroxide, 0.01 to 7 mass% of acetic acid and / or a salt thereof, and 0.00001 to 0.1 mass% of polyoxyethylene lauryl ether acetic acid or a salt thereof, The pH value of the diluted composition is 4.0 to 10.0. <6> The diluted composition described in

[0011] <8> It includes a mixing step of mixing at least the following components: <1> ~ <5> 10. A method for producing the composition according to any one of the preceding claims. (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts <9> It includes a mixing step of mixing at least the following components: <1> ~ <5> 10. A method for producing the composition according to any one of the preceding claims. (i) Additives containing phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) acetate (iv) Polyoxyethylene lauryl ether acetic acid or its salts <10> It includes a mixing step of mixing at least the following components: <1> ~ <5> 10. A method for producing the composition according to any one of the preceding claims. (i) Additives containing phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) Alkali (iv) Polyoxyethylene lauryl ether acetic acid or its salts <11> After mixing the additive, acetic acid, alkali, and polyoxyethylene lauryl ether acetic acid or a salt thereof, hydrogen peroxide water is added at 30 to 50°C. <10> The manufacturing method described in <12> a mixing step of mixing at least the following components: A dilution step of diluting the obtained mixture and <6> or <7> A method for producing the diluted composition described above. (i) Hydrogen peroxide and acetic acid (ii) Acetate or alkali (iii) Polyoxyethylene lauryl ether acetic acid or its salts <13> The diluting step includes mixing the mixture obtained in the mixing step with water. <12> A method for producing the diluted composition described above.

[0012] <14> <1> ~ <5> or a composition according to any one of <6> or <7> A method for sterilizing and cleaning medical instruments using the diluted composition described above. <15> The method for sterilizing and cleaning the medical instrument is any one of a dipping method, a spraying method, and a coating method. <14> The sterilization and cleaning method described in <16> The medical device is a dialysis device. <14> or <15> The sterilization and cleaning method described in

[0013] <17> A disinfecting and cleaning composition comprising 0.01 to 30 mass% of peracetic acid, 0.1 to 30 mass% of hydrogen peroxide, 1 to 60 mass% of acetic acid, 0.001 to 5 mass% of polyoxyethylene lauryl ether acetic acid or a salt thereof, and water. <18> further comprising a stabilizer, <17> The composition described in <19> The stabilizer is contained in an amount of 0.01 to 5% by mass. <18> The composition described in <20> The stabilizer is Phosphorus stabilizer That is, <18> or <19> The composition described in <21> The aforementioned Phosphorus stabilizer is selected from the group consisting of pyrophosphoric acid, phosphoric acid, 1-hydroxyethylidene-1,1-diphosphonic acid, nitrilotrismethylenephosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, and ethylenediaminetetramethylenephosphonic acid, and is preferably pyrophosphoric acid; <20> The composition described in <22> further comprising a chelating agent, <17> ~ <21> The composition according to any one of the preceding claims. <23> Contains 0.01 to 2 mass% of a chelating agent; <22> The composition described in <24> the chelating agent is selected from the group consisting of ethylenediaminetetraacetic acid, citric acid, malic acid, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and dipicolinic acid; <22> or <23> The composition described in

[0014] <25> <17> ~ <24> a composition according to any one of the preceding claims, additional water A diluted disinfecting and cleaning composition comprising: <26> containing 0.001 to 0.2 mass% of peracetic acid, 0.01 to 2 mass% of hydrogen peroxide, 0.01 to 1 mass% of acetic acid, and 0.00001 to 0.1 mass% of polyoxyethylene lauryl ether acetic acid or a salt thereof, <25> The diluted composition described in

[0015] <27> It includes a mixing step of mixing at least the following components: <17> ~ <24> 10. A method for producing the composition according to any one of the preceding claims. (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts <28> <17> ~ <24> 1. A method for producing the composition according to any one of the above, comprising the following steps (A) and (B): Step (A) A step of mixing at least acetic acid, a 30 to 65% by mass aqueous solution of hydrogen peroxide, and polyoxyethylene lauryl ether acetic acid or a salt thereof. Step (B) A step of leaving the aqueous solution (a) obtained in step (A) at 20 to 60°C for one day or more. <29> The step (A) further comprises mixing a chelating agent. <28> A method for producing the composition described above. <30> <17> ~ <24> 1. A method for producing the composition according to any one of the above, comprising the following steps (C) to (E): Step (C) A step of mixing at least acetic acid and a 30 to 65% by mass aqueous solution of hydrogen peroxide. Step (D): A step of leaving the aqueous solution (c) obtained in step (C) at 20 to 60°C for one day or more. Step (E): A step of mixing the aqueous solution (d) obtained in Step (D), polyoxyethylene lauryl ether acetic acid or a salt thereof, and water. <31> In the step (E), a chelating agent is further mixed. <30> A method for producing the composition described above. <32> a mixing step of mixing at least the following components: A dilution step of diluting the obtained mixture and <25> or <26> A method for producing the diluted composition described above. (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts <33> The diluting step includes mixing the mixture obtained in the mixing step with water. <32> A method for producing the diluted composition described above.

[0016] <34> <17> ~ <24> or a composition according to any one of <25> or <26> A method for sterilizing and cleaning medical instruments using the diluted composition described above. <35> The method for sterilizing and cleaning the medical instrument is any one of a dipping method, a spraying method, and a coating method. <34> The sterilization and cleaning method described in <36> The medical device is a dialysis device. <34> or <35> The sterilization and cleaning method described.

[0017] <37> containing 0.001 to 15 mass% of peracetic acid, 0.01 to 70 mass% of acetic acid and / or a salt thereof, 0.001 to 25 mass% of hydrogen peroxide, and water, Contains a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive. 1. A disinfecting and cleaning composition comprising: The sterilizing and cleaning composition has a pH value of 4.0 to 10.0. <38> the phosphorus-based stabilizer comprises 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, or diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, and is preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof; <37> The composition described in <39> the carboxylic acid stabilizer comprises either ethylenediaminetetraacetic acid (EDTA) or a salt thereof, or diethylenetriaminepentaacetic acid (DTPA) or a salt thereof, and is preferably ethylenediaminetetraacetic acid (EDTA) or a salt thereof; <37> or <38> The composition described in <40> the phosphorus-based stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, The carboxylic acid stabilizer is ethylenediaminetetraacetic acid (EDTA) or a salt thereof. <37> ~ <39> The composition according to any one of the preceding claims. <41> The phosphorus-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass, and the carboxylic acid-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass. <37> ~ <40> The composition according to any one of the preceding claims. <42> Further comprising one or more selected from phosphate, citrate, and Tris base; <37> ~ <41> The composition according to any one of the preceding claims. <43> Further, it contains sodium stannate as an additive. <37> ~ <42> The composition according to any one of the preceding claims. <44> The sodium stannate is contained in an amount of 0.0001 to 5% by mass. <43> The composition described in <45> containing 0.001 to 15 mass% of peracetic acid, 0.01 to 70 mass% of acetic acid and / or a salt thereof, 0.001 to 25 mass% of hydrogen peroxide, and water, Contains sodium stannate as an additive, 1. A disinfecting and cleaning composition comprising: The sterilizing and cleaning composition has a pH value of 4.0 to 10.0. <46> The sodium stannate is contained in an amount of 0.0001 to 5% by mass. <45> The composition described in <47> 47. The composition according to claim 45 or 46, further comprising a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive. <48> The phosphorus-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass, and the carboxylic acid-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass. <47> The composition described in <49> The pH value of the composition is 5.0 to 9.0. <37> ~ <48> The composition according to any one of the preceding claims.

[0018] <50> <37> ~ <49> a composition according to any one of the preceding claims, additional water A diluted disinfecting and cleaning composition comprising: <51> containing 0.001 to 1.5 mass% of peracetic acid, 0.01 to 7 mass% of acetic acid and / or a salt thereof, 0.001 to 2.5 mass% of hydrogen peroxide, and water, Contains a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, The pH value of the diluted composition for sterilization and cleaning is 4.0 to 10.0. <50> A diluted composition for disinfection and cleaning according to claim 1. <52> containing 0.001 to 1.5 mass% of peracetic acid, 0.01 to 7 mass% of acetic acid and / or a salt thereof, 0.001 to 2.5 mass% of hydrogen peroxide, and water, Contains sodium stannate as an additive, The pH value of the diluted composition for sterilization and cleaning is 4.0 to 10.0. <50> A diluted composition for disinfection and cleaning according to claim 1.

[0019] <53> The hydrogen peroxide is ultrapure hydrogen peroxide. <37> ~ <49> or <50> ~ <52> The diluted composition according to any one of the preceding claims. <54> The acetic acid is ultrapure acetic acid. <37> ~ <49> or <50> ~ <53> The diluted composition according to any one of the preceding claims.

[0020] <55> It includes a mixing step of mixing at least the following components: <37> ~ <49> , <53> , and <54> 10. A method for producing the composition according to any one of the preceding claims. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) one or more selected from phosphate, citrate, and Tris base <56> It includes a mixing step of mixing at least the following components: <37> ~ <49> , <53> , and <54> 10. A method for producing the composition according to any one of the preceding claims. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) Alkali <57> After mixing the additive, acetic acid, and alkali, hydrogen peroxide water is added at 30 to 50°C. <56> The manufacturing method described in <58> It includes a mixing step of mixing at least the following components: <37> ~ <49> , <53> , and <54> 10. A method for producing the composition according to any one of the preceding claims. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) acetate <59> The mixing step further comprises adding a metal selected from the group consisting of Al, Zr, and Nb. <55> ~ <58> 10. A method for producing the composition according to any one of the preceding claims.

[0021] <60> <37> ~ <49> , <53> and <54> The composition according to any one of the above <50> ~ <54> A method for sterilizing and cleaning medical instruments using the diluted composition described in any one of the above.

[0022] <61> The method for sterilizing and cleaning the medical instrument is any one of a dipping method, a spraying method, and a coating method. <60> The sterilization and cleaning method described in

[0023] <62> The medical device is a dialysis device. <60> or <61> The sterilization and cleaning method described in [Effects of the Invention]

[0024] According to one embodiment of the present invention, by adding a special anionic surfactant (polyoxyethylene lauryl ether acetic acid) to peracetic acid, it is possible to provide a sterilization and cleaning composition that has improved stability and bactericidal properties compared to conventional aqueous peracetic acid solutions, and also has scale removal capabilities. According to another embodiment of the present invention, by adding a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, it is possible to provide a composition for sterilizing and cleaning medical devices, in which the peroxide is highly stable and the wastewater meets sewage discharge standards. Because the pH value of this composition of the present invention meets sewage discharge standards, wastewater after use can be discharged without the need for neutralization treatment. All of the compositions of the present invention are suitable for sterilizing and cleaning medical devices, particularly dialysis devices. DETAILED DESCRIPTION OF THE INVENTION

[0025] [Embodiment A] A-1. Disinfecting and cleaning compositions The disinfecting and cleaning composition of the present invention comprises peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, polyoxyethylene lauryl ether acetic acid or a salt thereof, and water.

[0026] In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 4.0 to 10.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be, for example, 4.0, 4.5, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, etc., but is not limited to these values. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be, for example, 4.0 to 10.0, 4.0 to 9.5, 4.0 to 9.0, 4.0 to 8.5, 4.0 to 8.0, 4.0 to 7.5, 4.0 to 7.0, 4.0 to 6.5, or 4.0 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 4.5 to 10.0, 4.5 to 9.5, 4.5 to 9.0, 4.5 to 8.5, 4.5 to 8.0, 4.5 to 7.5, 4.5 to 7.0, 4.5 to 6.5, or 4.5 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.0 to 10.0, 5.0 to 9.5, 5.0 to 9.0, 5.0 to 8.5, 5.0 to 8.0, 5.0 to 7.5, 5.0 to 7.0, 5.0 to 6.5, or 5.0 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.1 to 10.0, 5.1 to 9.5, 5.1 to 9.0, 5.1 to 8.5, 5.1 to 8.0, 5.1 to 7.5, 5.1 to 7.0, 5.1 to 6.5, or 5.1 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.2 to 10.0, 5.2 to 9.5, 5.2 to 9.0, 5.2 to 8.5, 5.2 to 8.0, 5.2 to 7.5, 5.2 to 7.0, 5.2 to 6.5, or 5.2 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.3 to 10.0, 5.3 to 9.5, 5.3 to 9.0, 5.3 to 8.5, 5.3 to 8.0, 5.3 to 7.5, 5.3 to 7.0, 5.3 to 6.5, or 5.3 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.4 to 10.0, 5.4 to 9.5, 5.4 to 9.0, 5.4 to 8.5, 5.4 to 8.0, 5.4 to 7.5, 5.4 to 7.0, 5.4 to 6.5, or 5.4 to 6.0.In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.5 to 10.0, 5.5 to 9.5, 5.5 to 9.0, 5.5 to 8.5, 5.5 to 8.0, 5.5 to 7.5, 5.5 to 7.0, 5.5 to 6.5, or 5.5 to 6.0. In a preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5.0. In a preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5 and not greater than 10. In another preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5 and not greater than 9.

[0027] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.001 to 30% by mass of peracetic acid, 0.001 to 30% by mass of hydrogen peroxide, 1 to 70% by mass of acetic acid and / or a salt thereof, and 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof, The pH value of the composition may be 4.0 to 10.0.

[0028] The sterilizing and cleaning composition of the present invention may contain 0.01 to 15% by mass of the peracetic acid, 0.01 to 25% by mass of the hydrogen peroxide, 1 to 60% by mass of the acetic acid and / or a salt thereof, and 0.001 to 2% by mass of the polyoxyethylene lauryl ether acetic acid or a salt thereof, The pH value of the composition may be 4.0 to 10.0.

[0029] The sterilizing and cleaning composition of the present invention may contain 0.05 to 15% by mass of the peracetic acid, 0.02 to 20% by mass of the hydrogen peroxide, 5 to 50% by mass of the acetic acid and / or a salt thereof, and 0.001 to 1% by mass of the polyoxyethylene lauryl ether acetic acid or a salt thereof, The pH value of the composition may be 4.0 to 10.0.

[0030] In one embodiment of the present invention, the sterilizing and cleaning composition may further contain a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive. In the sterilizing and cleaning composition of the present invention, the concentration of the phosphorus-based stabilizer and / or the carboxylic acid-based stabilizer may be 0.0001 to 5% by mass.

[0031] Each component will be described below.

[0032] (1) Polyoxyethylene lauryl ether acetic acid or its salt The disinfecting and cleaning composition of the present invention contains polyoxyethylene lauryl ether acetic acid or a salt thereof as an anionic surfactant. The polyoxyethylene lauryl ether acetic acid used in the disinfecting and cleaning composition of the present invention is represented by the following general formula. The salt of polyoxyethylene lauryl ether acetic acid may be, for example, a sodium salt, a potassium salt, etc., but is not limited to these. The polyoxyethylene lauryl ether acetic acid or a salt thereof is preferably polyoxyethylene lauryl ether acetic acid. R1-(O-R2)nO-R3-COOH (In the formula, R1 is a lauryl group, R2 is an ethylene group, R3 is a methylene group, and n is a number from 1 to 30.)

[0033] In a preferred embodiment, n may be 2 to 20. In a preferred embodiment, n may be, for example, but not limited to, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 11, 12, 13, 14, or 15. In a more preferred embodiment, n is 4.5 or 10.

[0034] The molecular weight of polyoxyethylene lauryl ether acetic acid or a salt thereof used in the disinfecting and cleaning composition of the present invention may be 300 to 1200. In a preferred embodiment, the molecular weight of polyoxyethylene lauryl ether acetic acid or a salt thereof is 400 to 1000.

[0035] In the disinfecting and cleaning composition of the present invention, the concentration of polyoxyethylene lauryl ether acetic acid or a salt thereof may be 0.001 to 5% by mass, preferably 0.001 to 2% by mass, and more preferably 0.001 to 1% by mass.

[0036] (2) Other ingredients <Hydrogen peroxide> The sterilizing and cleaning composition of the present invention contains hydrogen peroxide. Because hydrogen peroxide itself has sterilizing and cleaning properties, it not only contributes to enhancing the sterilizing and cleaning effects of the entire composition, but also contributes to the production and maintenance (stability in aqueous solution) of a sufficient amount of peracetic acid through an equilibrium reaction with acetic acid. Therefore, the combination of acetic acid and hydrogen peroxide can further enhance the sterilizing and cleaning effects of the composition of the present invention.

[0037] The concentration of hydrogen peroxide in the sterilizing and cleaning composition of the present invention is preferably 0.001 to 30% by mass, more preferably 0.01 to 25% by mass, and even more preferably 0.02 to 20% by mass. If the hydrogen peroxide concentration is too low, the amount of peracetic acid produced by the equilibrium reaction with acetic acid will be insufficient, and the sterilizing and cleaning effects of the present invention may not be fully exerted. On the other hand, if the hydrogen peroxide concentration is too high, the effects will not be enhanced and may even pose safety concerns.

[0038] <Acetic acid and / or its salts> The acetic acid and / or salts thereof used in the disinfecting and cleaning composition of the present invention may be those commonly used in the art.

[0039] The concentration of acetic acid and / or a salt thereof in the disinfecting and cleaning composition of the present invention may be preferably 1 to 70 mass %, more preferably 1 to 60 mass %, and even more preferably 5 to 50 mass %.

[0040] <Peracetic acid> The peracetic acid used in the disinfecting and cleaning composition of the present invention may be any peracetic acid commonly used in the art.

[0041] The concentration of peracetic acid in the disinfecting and cleaning composition of the present invention may be preferably 0.001 to 30% by mass, more preferably 0.01 to 15% by mass, and even more preferably 0.05 to 15% by mass.

[0042] <Stabilizer> The disinfecting and cleaning composition of the present invention may contain a stabilizer as an additive. The addition of a stabilizer improves the stability of hydrogen peroxide. Any stabilizer for hydrogen peroxide can be used as the stabilizer, for example, a phosphate stabilizer and / or a carboxylic acid stabilizer. Examples of phosphorus-based stabilizers that can be used in the disinfecting and cleaning composition of the present invention include, but are not limited to, pyrophosphoric acid or a salt thereof, phosphoric acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, nitrilotrismethylenephosphonic acid or a salt thereof, 2-phosphonobutane-1,2,4-tricarboxylic acid or a salt thereof, and ethylenediaminetetramethylenephosphonic acid or a salt thereof. The phosphorus-based stabilizer is preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof. Examples of carboxylic acid stabilizers that can be used in the disinfecting and cleaning compositions of the present invention include, but are not limited to, ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethylenetriaminepentaacetic acid (DTPA) or a salt thereof, picolinic acid or a salt thereof, dipicolinic acid or a salt thereof, nitrilotriacetic acid or a salt thereof, N-(2-hydroxyethyl)ethylenediamine-N,N',N"-triacetic acid or a salt thereof, triethylenetetramine-N,N,N',N",N"',N"'-hexaacetic acid or a salt thereof, 1,3-propanediamine-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-propanol-N,N,N',N'-tetraacetic acid, N-(2-hydroxyethyl)iminodiacetic acid or a salt thereof, N,N-di(2-hydroxyethyl)glycine or a salt thereof, glycol ether diaminetetraacetic acid, and (S,S)-ethylenediamine-N,N'-disuccinic acid or a salt thereof. The carboxylic acid stabilizer is preferably ethylenediaminetetraacetic acid (EDTA) or a salt thereof.

[0043] In the disinfecting and cleaning composition of the present invention, the concentration of the stabilizer may be preferably 0.0001 to 5% by mass, more preferably 0.0001 to 2% by mass, and even more preferably 0.0002 to 1% by mass.

[0044] <Other ingredients> The disinfecting and cleaning composition of the present invention may further contain, as necessary, additives used in general disinfecting and cleaning agents, such as surfactants, thickeners, fragrances, colorants, hydrolases, etc. In the disinfecting and cleaning composition of the present invention, the remainder other than polyoxyethylene lauryl ether acetic acid or a salt thereof, hydrogen peroxide, acetic acid, peracetic acid, and stabilizers and other additives added as needed is mainly water.

[0045] The sterilizing and cleaning composition of the present invention can be used as is without dilution, or can be diluted to any concentration to form a diluted sterilizing and cleaning composition. Water is usually used as a diluent. Examples of water used as a diluent include pure water, ultrapure water, distilled water, purified water, water for injection, and tap water. The dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted sterilizing and cleaning composition to have a sterilizing and cleaning effect, but is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0046] A-2. Diluted composition for disinfection and cleaning The diluted disinfecting and cleaning composition of the present invention contains peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, as well as additional water as a diluent. Each component is as described above.

[0047] The diluted composition for sterilization and cleaning of the present invention is AssemblingAs described above, the dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted composition for sterilization and cleaning to have a concentration that exhibits sterilization and cleaning effects, but is preferably 1 to 10,000 times, more preferably 1 to 1,000 times.

[0048] In one embodiment of the present invention, the diluted composition for sterilization and cleaning may contain 0.001 to 1.5 mass% peracetic acid, 0.001 to 2.5 mass% hydrogen peroxide, 0.01 to 7 mass% acetic acid and / or a salt thereof, and 0.00001 to 0.1 mass% polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0049] The diluted composition for sterilization and cleaning of the present invention may contain 0.001 to 0.5 mass% of the peracetic acid, 0.005 to 1 mass% of the hydrogen peroxide, 0.05 to 5 mass% of the acetic acid and / or a salt thereof, and 0.00005 to 0.05 mass% of the polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0050] A-3. Method for producing disinfectant and cleaning composition and diluted disinfectant and cleaning composition In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts The method may include a mixing step of mixing the above components. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. The order in which the components are mixed may be arbitrary, and in the disinfecting and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0051] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives containing phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) acetate (iv) Polyoxyethylene lauryl ether acetic acid or its salts The method may include a mixing step of mixing the above ingredients.

[0052] The acetate may be any acetate that is alkaline when dissolved in an aqueous solution, including, but not limited to, sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate, barium acetate, and ammonium acetate. In one embodiment of the present invention, the acetate may be sodium acetate. In another embodiment of the present invention, the acetate may be potassium acetate.

[0053] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives containing phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) Alkali (iv) Polyoxyethylene lauryl ether acetic acid or its salts The method may include a mixing step of mixing the above ingredients.

[0054] In this manufacturing method, neutralization heat is generated, which increases the parallel migration rate and accelerates the reaction. When the aqueous solution reaches equilibrium, peracetic acid also exists in the aqueous solution, and peracetic acid may be added in the mixing step. Each component is as described above. The order of mixing each component may be arbitrary, and in the sterilizing and cleaning composition of the present invention, each mixed component is in equilibrium.

[0055] Examples of the alkali that can be used include, but are not limited to, sodium hydroxide, potassium hydroxide, lithium hydroxide, beryllium hydroxide, magnesium hydroxide, aluminum hydroxide, calcium hydroxide, rubidium hydroxide, strontium hydroxide, cesium hydroxide, barium hydroxide, and ammonia. In one embodiment of the present invention, the alkali may be sodium hydroxide. In another embodiment of the present invention, the alkali may be potassium hydroxide.

[0056] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) one or more selected from phosphate, citrate, and Tris base (iv) Polyoxyethylene lauryl ether acetic acid or its salts The method may include a mixing step of mixing the above components. By adding one or more selected from phosphate, citrate, and Tris base, the change in pH after dilution can be reduced. In this manufacturing method, when a phosphate or citrate is used as (iii), neutralization heat is not generated, resulting in good workability. Furthermore, in this manufacturing method, when a Tris base is used as (iii), neutralization heat is generated, increasing the translation speed and accelerating the reaction. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. The order in which the components are mixed may be arbitrary, and in the sterilizing and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0057] Examples of the phosphate salt include, but are not limited to, sodium salt of phosphoric acid, potassium salt of phosphoric acid, etc. Examples of the sodium salt of phosphoric acid include, but are not limited to, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, etc. Examples of the potassium salt of phosphoric acid include, but are not limited to, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, etc.

[0058] The above tris base means tris(hydroxymethyl)aminomethane.

[0059] The above production method using an alkali or Tris base may include a step of mixing an additive, acetic acid, an alkali or Tris base, and polyoxyethylene lauryl ether acetic acid or a salt thereof, followed by mixing with hydrogen peroxide at 30 to 50° C. In this production method, neutralization heat is generated, and therefore the hydrogen peroxide can be mixed at 30 to 50° C. by utilizing the neutralization heat generated by mixing the additive, acetic acid, and alkali or Tris base, thereby increasing the translation rate and accelerating the reaction.

[0060] In one embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (A) and (B): Step (A) mixing at least (i) an additive, (ii) hydrogen peroxide solution and acetic acid, (iii) acetate or alkali, or one or more selected from phosphate, citrate, and Tris base, and (iv) polyoxyethylene lauryl ether acetic acid or a salt thereof; Step (B) A step of leaving the aqueous solution (a) obtained in step (A) standing for one day or more. The aqueous solution (a) obtained in step (A) is allowed to stand in step (B), whereby the aqueous solution reaches an equilibrium state. In an embodiment using an acetate, a phosphate, or a citrate, the temperature at which the solution is allowed to stand in step (B) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for which the solution is allowed to stand in step (B) is preferably 1 day or more, and may be, for example, 2 days or more, 3 days or more, 5 days or more, 10 days or more, or 30 days or more. In an embodiment using an alkali or a Tris base, the reaction can be accelerated by the generation of heat of neutralization, as described above.

[0061] In yet another embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (C) to (E): Step (C) mixing at least (ii) hydrogen peroxide solution and acetic acid, and (i) an additive; Step (D) is a step of leaving the aqueous solution (c) obtained in Step (C) to stand for one day or more; Step (E) A step of mixing the aqueous solution (d) obtained in Step (D), (iii) one or more selected from acetate, alkali, phosphate, citrate, and Tris base, (iv) polyoxyethylene lauryl ether acetic acid or a salt thereof, and water. The aqueous solution (c) obtained in step (C) is allowed to stand, thereby allowing the aqueous solution to reach an equilibrium state. The temperature at which the solution is allowed to stand in step (D) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for allowing the solution to stand in step (D) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, or 30 days or more. Thereafter, an acetate, an alkali, or one or more selected from a phosphate, a citrate, and a Tris base, and water are mixed with the aqueous solution (d) that has reached an equilibrium state.

[0062] In one embodiment of the present invention, a method for preparing a diluted disinfecting and cleaning composition comprises mixing at least the following components: (i) Additives containing phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) one or more selected from acetate, alkali, phosphate, citrate, and Tris base (iv) Polyoxyethylene lauryl ether acetic acid or its salts a mixing step of mixing the above ingredients; A dilution step of diluting the obtained mixture The aqueous solution may contain peracetic acid. When the aqueous solution reaches equilibrium, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. In the method for producing a diluted composition for sterilization and cleaning of the present invention, the dilution step may include mixing the mixture obtained in the mixing step with water. The water used as a diluent may be, for example, pure water, ultrapure water, distilled water, purified water, water for injection, tap water, etc.

[0063] [Embodiment B] B-1. Disinfecting and cleaning compositions The disinfecting and cleaning composition of the present invention comprises peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, polyoxyethylene lauryl ether acetic acid or a salt thereof, and water.

[0064] In one embodiment of the present invention, the disinfecting and cleaning composition may contain 0.01 to 30% by mass of peracetic acid, 0.1 to 30% by mass of hydrogen peroxide, 1 to 60% by mass of acetic acid, and 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0065] The disinfecting and cleaning composition of the present invention may contain 0.1 to 15 mass% of the peracetic acid, 1 to 25 mass% of the hydrogen peroxide, 1 to 50 mass% of the acetic acid, and 0.001 to 2 mass% of the polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0066] The disinfecting and cleaning composition of the present invention may contain 0.5 to 15 mass% of the peracetic acid, 2 to 20 mass% of the hydrogen peroxide, 5 to 50 mass% of the acetic acid, and 0.001 to 1 mass% of the polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0067] Each component will be described below.

[0068] (1) Polyoxyethylene lauryl ether acetic acid or its salt The disinfecting and cleaning composition of the present invention contains polyoxyethylene lauryl ether acetic acid or a salt thereof as an anionic surfactant. The polyoxyethylene lauryl ether acetic acid used in the disinfecting and cleaning composition of the present invention is represented by the following general formula. The salt of polyoxyethylene lauryl ether acetic acid may be, for example, a sodium salt, a potassium salt, etc., but is not limited to these. The polyoxyethylene lauryl ether acetic acid or a salt thereof is preferably polyoxyethylene lauryl ether acetic acid. R1-(O-R2)nO-R3-COOH (In the formula, R1 is a lauryl group, R2 is an ethylene group, R3 is a methylene group, and n is a number from 1 to 30.)

[0069] In a preferred embodiment, n may be 2 to 20. In a preferred embodiment, n may be, for example, but not limited to, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 11, 12, 13, 14, or 15. In a more preferred embodiment, n is 4.5 or 10.

[0070] The molecular weight of polyoxyethylene lauryl ether acetic acid or a salt thereof used in the disinfecting and cleaning composition of the present invention may be 300 to 1200. In a preferred embodiment, the molecular weight of polyoxyethylene lauryl ether acetic acid or a salt thereof is 400 to 1000.

[0071] In the disinfecting and cleaning composition of the present invention, the concentration of polyoxyethylene lauryl ether acetic acid or a salt thereof may be 0.001 to 5% by mass. The concentration of polyoxyethylene lauryl ether acetic acid or a salt thereof may be preferably 0.001 to 2% by mass, and more preferably 0.001 to 1% by mass. In one embodiment of the present invention, the concentration of polyoxyethylene lauryl ether acetic acid or a salt thereof may be 0.01 to 5% by mass, 0.01 to 2% by mass, 0.01 to 1% by mass, or the like.

[0072] (2) Other ingredients <Hydrogen peroxide> The sterilizing and cleaning composition of the present invention contains hydrogen peroxide. Because hydrogen peroxide itself has sterilizing and cleaning properties, it not only contributes to enhancing the sterilizing and cleaning effects of the entire composition, but also contributes to the production and maintenance (stability in aqueous solution) of a sufficient amount of peracetic acid through an equilibrium reaction with acetic acid. Therefore, the combination of acetic acid and hydrogen peroxide can further enhance the sterilizing and cleaning effects of the composition of the present invention.

[0073] The concentration of hydrogen peroxide in the sterilizing and cleaning composition of the present invention is preferably 0.1 to 30% by mass, more preferably 1 to 25% by mass, and even more preferably 2 to 20% by mass. If the hydrogen peroxide concentration is too low, the amount of peracetic acid produced by the equilibrium reaction with acetic acid will be insufficient, and the sterilizing and cleaning effects of the present invention may not be fully exerted. On the other hand, if the hydrogen peroxide concentration is too high, the effects will not be enhanced and may even pose safety problems.

[0074] <Acetic acid> The acetic acid used in the disinfecting and cleaning composition of the present invention may be any acetic acid commonly used in the art.

[0075] The concentration of acetic acid in the disinfecting and cleaning composition of the present invention may be preferably 1 to 60% by mass, more preferably 1 to 50% by mass, and even more preferably 5 to 50% by mass.

[0076] <Peracetic acid> The peracetic acid used in the disinfecting and cleaning composition of the present invention may be any peracetic acid commonly used in the art.

[0077] The concentration of peracetic acid in the disinfecting and cleaning composition of the present invention may be preferably 0.01 to 30% by mass, more preferably 0.1 to 15% by mass, and even more preferably 0.5 to 15% by mass.

[0078] <Stabilizer> The disinfecting and cleaning composition of the present invention may contain a stabilizer. The addition of a stabilizer improves the stability of hydrogen peroxide. Any stabilizer for hydrogen peroxide can be used as the stabilizer, for example, a phosphate-based stabilizer. Examples of phosphorus-based stabilizers that can be used in the disinfecting and cleaning composition of the present invention include, but are not limited to, pyrophosphoric acid, phosphoric acid, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), nitrilotrismethylenephosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, and ethylenediaminetetramethylenephosphonic acid. The phosphorus-based stabilizer is preferably pyrophosphate.

[0079] In the disinfecting and cleaning composition of the present invention, the concentration of the stabilizer may be preferably 0.01 to 5% by mass, more preferably 0.01 to 2% by mass, and even more preferably 0.02 to 1% by mass.

[0080] <Chelating agent> The disinfecting and cleaning composition of the present invention may contain a chelating agent. The inclusion of a chelating agent improves the effects of inhibiting scale formation, removing scale, and removing protein. Examples of chelating agents that can be used in the disinfecting and cleaning composition of the present invention include, but are not limited to, ethylenediaminetetraacetic acid, citric acid, malic acid, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and dipicolinic acid. The chelating agent is preferably dipicolinic acid.

[0081] <Other ingredients> The disinfecting and cleaning composition of the present invention may further contain, as necessary, additives used in general disinfecting and cleaning agents, such as surfactants, thickeners, fragrances, colorants, hydrolases, etc. In the disinfecting and cleaning composition of the present invention, the remainder other than polyoxyethylene lauryl ether acetic acid or a salt thereof, hydrogen peroxide, acetic acid, peracetic acid, and stabilizers and other additives added as needed is mainly water.

[0082] The pH of the sterilizing and cleaning composition of the present invention is not more than 7, and preferably not more than 5. If the pH exceeds 7, hydrogen peroxide and peracetic acid may decompose, resulting in a decrease in stability.

[0083] The sterilizing and cleaning composition of the present invention can be used as is without dilution, or can be diluted to any concentration to form a diluted sterilizing and cleaning composition. Water is usually used as a diluent. Examples of water used as a diluent include pure water, ultrapure water, distilled water, purified water, water for injection, and tap water. The dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted sterilizing and cleaning composition to have a sterilizing and cleaning effect, but is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0084] B-2. Diluted composition for disinfection and cleaning The diluted disinfecting and cleaning composition of the present invention contains peracetic acid, hydrogen peroxide, acetic acid, polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, as well as additional water as a diluent. Each component is as described above.

[0085] The diluted composition for sterilization and cleaning of the present invention is Assembling As described above, the dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted composition for sterilization and cleaning to have a concentration that exhibits sterilization and cleaning effects, but is preferably 1 to 10,000 times, more preferably 1 to 1,000 times.

[0086] In one embodiment of the present invention, the diluted composition for sterilization and cleaning may contain 0.001 to 0.2 mass% of peracetic acid, 0.01 to 2 mass% of hydrogen peroxide, 0.01 to 1 mass% of acetic acid, and 0.00001 to 0.1 mass% of polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0087] The diluted composition for sterilization and cleaning of the present invention may contain 0.005 to 0.1 mass% of the peracetic acid, 0.01 to 1 mass% of the hydrogen peroxide, 0.05 to 0.5 mass% of the acetic acid, and 0.0001 to 0.1 mass% of the polyoxyethylene lauryl ether acetic acid or a salt thereof.

[0088] B-3. ​​Method for producing disinfectant and cleaning composition and diluted disinfectant and cleaning composition In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts The method may include a mixing step of mixing the above components. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. The order in which the components are mixed may be arbitrary, and in the disinfecting and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0089] In another embodiment of the present invention, a method for producing a disinfectant and cleaning composition comprises the following steps (A) and (B): Step (A) mixing at least acetic acid, a 30 to 65% by mass aqueous solution of hydrogen peroxide, and polyoxyethylene lauryl ether acetic acid or a salt thereof; Step (B) A step of leaving the aqueous solution (a) obtained in step (A) at 20 to 60°C for one day or more. The aqueous solution (a) obtained in step (A) may be allowed to stand in step (B), whereby the aqueous solution reaches an equilibrium state. The temperature at which the solution is allowed to stand in step (B) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for which the solution is allowed to stand in step (B) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, or 30 days or more. In the method for producing the sterilizing and cleaning composition of the present invention, step (A) may further comprise mixing a chelating agent. The chelating agent is as described above.

[0090] In yet another embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (C) to (E): Step (C) mixing at least acetic acid and a 30 to 65 mass % aqueous solution of hydrogen peroxide; Step (D) is a step of allowing the aqueous solution (c) obtained in Step (C) to stand at 20 to 60°C for one day or more; Step (E): A step of mixing the aqueous solution (d) obtained in Step (D), polyoxyethylene lauryl ether acetic acid or a salt thereof, and water. The aqueous solution (c) obtained in step (C) is allowed to stand, thereby allowing the aqueous solution to reach an equilibrium state. The temperature at which the solution is allowed to stand in step (D) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for allowing the solution to stand in step (D) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, or 30 days or more. Thereafter, polyoxyethylene lauryl ether acetic acid or a salt thereof, and water are mixed with the aqueous solution (d) that has reached an equilibrium state. In the sterilizing and cleaning composition of the present invention, the mixed components are in an equilibrium state. In the method for producing the sterilizing and cleaning composition of the present invention, step (E) may further include mixing a chelating agent. The chelating agent is as described above.

[0091] In one embodiment of the present invention, a method for preparing a diluted disinfecting and cleaning composition comprises mixing at least the following components: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or its salts a mixing step of mixing the above ingredients; A dilution step of diluting the obtained mixture The aqueous solution may contain peracetic acid. When the aqueous solution reaches equilibrium, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. Each component is as described above. In the method for producing the diluted composition for sterilization and cleaning of the present invention, the dilution step may include mixing the mixture obtained in the mixing step with water. The water used as a diluent may be, for example, pure water, ultrapure water, distilled water, purified water, water for injection, tap water, etc. In the diluted composition for sterilization and cleaning of the present invention, the mixed components are in equilibrium.

[0092] [Embodiment C] C-1. Disinfecting and cleaning compositions In one embodiment of the present invention, the disinfecting and cleaning composition comprises peracetic acid, hydrogen peroxide, acetic acid and / or its salts, and water, and as an additive, a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer.

[0093] In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 4.0 to 10.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be, for example, 4.0, 4.5, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, etc., but is not limited to these values. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be, for example, 4.0 to 10.0, 4.0 to 9.5, 4.0 to 9.0, 4.0 to 8.5, 4.0 to 8.0, 4.0 to 7.5, 4.0 to 7.0, 4.0 to 6.5, or 4.0 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 4.5 to 10.0, 4.5 to 9.5, 4.5 to 9.0, 4.5 to 8.5, 4.5 to 8.0, 4.5 to 7.5, 4.5 to 7.0, 4.5 to 6.5, or 4.5 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.0 to 10.0, 5.0 to 9.5, 5.0 to 9.0, 5.0 to 8.5, 5.0 to 8.0, 5.0 to 7.5, 5.0 to 7.0, 5.0 to 6.5, or 5.0 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.1 to 10.0, 5.1 to 9.5, 5.1 to 9.0, 5.1 to 8.5, 5.1 to 8.0, 5.1 to 7.5, 5.1 to 7.0, 5.1 to 6.5, or 5.1 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.2 to 10.0, 5.2 to 9.5, 5.2 to 9.0, 5.2 to 8.5, 5.2 to 8.0, 5.2 to 7.5, 5.2 to 7.0, 5.2 to 6.5, or 5.2 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.3 to 10.0, 5.3 to 9.5, 5.3 to 9.0, 5.3 to 8.5, 5.3 to 8.0, 5.3 to 7.5, 5.3 to 7.0, 5.3 to 6.5, or 5.3 to 6.0. In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.4 to 10.0, 5.4 to 9.5, 5.4 to 9.0, 5.4 to 8.5, 5.4 to 8.0, 5.4 to 7.5, 5.4 to 7.0, 5.4 to 6.5, or 5.4 to 6.0.In one embodiment of the present invention, the pH value of the sterilizing and cleaning composition may be 5.5 to 10.0, 5.5 to 9.5, 5.5 to 9.0, 5.5 to 8.5, 5.5 to 8.0, 5.5 to 7.5, 5.5 to 7.0, 5.5 to 6.5, or 5.5 to 6.0. In a preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5.0. In a preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5 and not greater than 10. In another preferred embodiment of the present invention, the pH value of the sterilizing and cleaning composition is greater than 5 and not greater than 9.

[0094] In one embodiment of the present invention, the disinfecting and cleaning composition comprises 0.001 to 15% by mass of peracetic acid, 0.01 to 70% by mass of acetic acid and / or a salt thereof, 0.001 to 25% by mass of hydrogen peroxide, and water, Contains a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, The pH value of the composition may be 4.0 to 10.0.

[0095] In one embodiment of the present invention, the disinfecting and cleaning composition may further contain one or more selected from phosphates, citrates, and Tris bases. In the disinfecting and cleaning composition of the present invention, the concentration of the one or more selected from phosphates, citrates, and Tris bases may be 0.01 to 70% by mass.

[0096] In one embodiment of the present invention, the disinfecting and cleaning composition may further contain sodium stannate. The concentration of sodium stannate in the disinfecting and cleaning composition of the present invention may be 0.0001 to 5% by mass.

[0097] In another embodiment of the present invention, the disinfecting and cleaning composition comprises 0.001 to 15% by mass of peracetic acid, 0.01 to 70% by mass of acetic acid and / or a salt thereof, 0.001 to 25% by mass of hydrogen peroxide, and water, Contains sodium stannate as an additive, The pH value of the composition may be 4.0 to 10.0. In the disinfecting and cleaning composition of the present invention, the concentration of sodium stannate may be 0.0001 to 5% by mass.

[0098] In one embodiment of the present invention, the disinfecting and cleaning composition may further contain a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer. In the disinfecting and cleaning composition of the present invention, the concentration of the phosphorus-based stabilizer may be 0.0001% by weight or more and less than 0.5% by weight, and the concentration of the carboxylic acid-based stabilizer may be 0.0001% by weight or more and less than 0.5% by weight.

[0099] Each component will be described below.

[0100] (1) Additives (1-1) Stabilizer The sterilizing and cleaning composition of the present invention contains peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, and water, and may contain a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive. The addition of these stabilizers improves the stability of hydrogen peroxide and enables the pH value of the sterilizing and cleaning composition to be adjusted to 4.0 to 10.0. The sterilizing and cleaning composition of the present invention may contain the phosphorus-based stabilizer and / or the carboxylic acid-based stabilizer alone or in combination with sodium stannate as an additive. The sterilizing and cleaning composition of the present invention may further contain one or more additives selected from phosphates, citrates, and tris bases.

[0101] <Phosphorus-based stabilizer> The disinfectant and cleaning composition of the present invention may contain a phosphorus-based stabilizer as an additive. Any phosphorus-based stabilizer can be used as long as it stabilizes hydrogen peroxide and, when added together with a carboxylic acid-based stabilizer, can adjust the pH value of the disinfectant and cleaning composition to the above range. Examples of phosphorus-based stabilizers that can be used in the disinfectant and cleaning composition of the present invention include, but are not limited to, pyrophosphoric acid or a salt thereof, phosphoric acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, nitrilotrismethylenephosphonic acid or a salt thereof, 2-phosphonobutane-1,2,4-tricarboxylic acid or a salt thereof, and ethylenediaminetetramethylenephosphonic acid or a salt thereof. In one embodiment of the present invention, the phosphorus-based stabilizer may be 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof. In another embodiment of the present invention, the phosphorus-based stabilizer may be diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof. In yet another embodiment of the present invention, the phosphorus-based stabilizer may be pyrophosphoric acid or a salt thereof. In a preferred embodiment of the present invention, the phosphorus-based stabilizer may be 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof.

[0102] In the disinfecting and cleaning composition of the present invention, the concentration of the phosphorus-based stabilizer may be 0.0001% by mass or more and less than 0.5% by mass, preferably 0.0001 to 0.30% by mass, more preferably 0.0001 to 0.20% by mass, and even more preferably 0.0001 to 0.10% by mass.

[0103] <Carboxylic acid stabilizer> The disinfecting and cleaning composition of the present invention may contain a carboxylic acid stabilizer as an additive, which can stabilize hydrogen peroxide and adjust the pH value of the disinfecting and cleaning composition to the above range when added together with the phosphorus stabilizer. Examples of carboxylic acid stabilizers that can be used in the disinfecting and cleaning compositions of the present invention include, but are not limited to, ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethylenetriaminepentaacetic acid (DTPA) or a salt thereof, picolinic acid or a salt thereof, dipicolinic acid or a salt thereof, nitrilotriacetic acid or a salt thereof, N-(2-hydroxyethyl)ethylenediamine-N,N',N"-triacetic acid or a salt thereof, triethylenetetramine-N,N,N',N",N"',N"'-hexaacetic acid or a salt thereof, 1,3-propanediamine-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-propanol-N,N,N',N'-tetraacetic acid, N-(2-hydroxyethyl)iminodiacetic acid or a salt thereof, N,N-di(2-hydroxyethyl)glycine or a salt thereof, glycol ether diaminetetraacetic acid, and (S,S)-ethylenediamine-N,N'-disuccinic acid or a salt thereof. In one embodiment of the present invention, the carboxylic acid stabilizer may be ethylenediaminetetraacetic acid (EDTA) or a salt thereof. In another embodiment of the present invention, the carboxylic acid stabilizer may be diethylenetriaminepentaacetic acid (DTPA) or a salt thereof. In a preferred embodiment of the present invention, the carboxylic acid stabilizer may be ethylenediaminetetraacetic acid (EDTA) or a salt thereof.

[0104] In the disinfecting and cleaning composition of the present invention, the concentration of the carboxylic acid stabilizer may be 0.0001% by mass or more and less than 0.5% by mass, preferably 0.0001 to 0.30% by mass, more preferably 0.0001 to 0.20% by mass, and even more preferably 0.0001 to 0.10% by mass.

[0105] In one embodiment of the present invention, the disinfecting and cleaning composition comprises: The phosphorus-based stabilizer includes 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, or diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, The carboxylic acid stabilizer may include ethylenediaminetetraacetic acid (EDTA) or a salt thereof, or diethylenetriaminepentaacetic acid (DTPA) or a salt thereof.

[0106] In one embodiment of the present invention, the disinfecting and cleaning composition comprises: The phosphorus-based stabilizer includes 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, The carboxylic acid stabilizer may include ethylenediaminetetraacetic acid (EDTA) or a salt thereof.

[0107] In one embodiment of the present invention, the disinfecting and cleaning composition may contain 0.0001% by weight or more but less than 0.5% by weight of the phosphorus-based stabilizer and 0.0001% by weight or more but less than 0.5% by weight of the carboxylic acid-based stabilizer.

[0108] In one embodiment of the present invention, the disinfecting and cleaning composition contains the phosphorus-based stabilizer in an amount of 0.0001 to 0.30% by mass, and Before The carboxylic acid stabilizer may be contained in an amount of 0.0001 to 0.30% by mass.

[0109] In one embodiment of the present invention, the disinfecting and cleaning composition contains the phosphorus-based stabilizer in an amount of 0.0001 to 0.20% by mass, and Before The carboxylic acid stabilizer may be contained in an amount of 0.0001 to 0.20% by mass.

[0110] In one embodiment of the present invention, the disinfecting and cleaning composition contains the phosphorus-based stabilizer in an amount of 0.0001 to 0.10% by mass, and Before The carboxylic acid stabilizer may be contained in an amount of 0.0001 to 0.10% by mass.

[0111] (1-2) Sodium stannate The sterilizing and cleaning composition of the present invention contains peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, and water, and may contain sodium stannate as an additive. The addition of sodium stannate improves the stability of hydrogen peroxide and enables the pH value of the sterilizing and cleaning composition to be adjusted to 4.0 to 10.0. The sterilizing and cleaning composition of the present invention may contain sodium stannate alone as an additive, or in combination with a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer.

[0112] In the disinfecting and cleaning composition of the present invention, the concentration of the sodium stannate may be 0.0001 to 5 mass%, preferably 0.0001 to 1 mass%, more preferably 0.0001 to 0.5 mass%, and even more preferably 0.0001 to 0.2 mass%.

[0113] (1-3) Phosphate, citrate, and Tris base The disinfecting and cleaning composition of the present invention contains peracetic acid, hydrogen peroxide, acetic acid and / or a salt thereof, and water, and may further contain one or more additives selected from phosphate, citrate, and Tris base. By adding one or more additives selected from phosphate, citrate, and Tris base, the change in pH after dilution can be reduced.

[0114] Phosphate salts that can be used in the disinfecting and cleaning composition of the present invention include, but are not limited to, sodium salts of phosphoric acid, potassium salts of phosphoric acid, etc. Sodium salts of phosphoric acid include, but are not limited to, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, etc. Potassium salts of phosphoric acid include, but are not limited to, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, etc.

[0115] The Tris base that may be used in the disinfecting and cleaning compositions of the present invention refers to tris(hydroxymethyl)aminomethane.

[0116] (2) Other ingredients <Hydrogen peroxide> The sterilizing and cleaning composition of the present invention contains hydrogen peroxide. Because hydrogen peroxide itself has sterilizing and cleaning properties, it not only contributes to enhancing the sterilizing and cleaning effects of the entire composition, but also contributes to the production and maintenance (stability in aqueous solution) of a sufficient amount of peracetic acid through an equilibrium reaction with acetic acid. Therefore, the combination of acetic acid and hydrogen peroxide can further enhance the sterilizing and cleaning effects of the composition of the present invention.

[0117] The concentration of hydrogen peroxide in the sterilizing and cleaning composition of the present invention may be 0.001 to 25% by mass, preferably 0.005 to 20% by mass, more preferably 0.01 to 15% by mass, and even more preferably 0.02 to 10% by mass. If the hydrogen peroxide concentration is too low, the amount of peracetic acid produced by the equilibrium reaction with acetic acid may be insufficient, and the sterilizing and cleaning effects of the present invention may not be fully exerted. On the other hand, if the hydrogen peroxide concentration is too high, the effects will not be enhanced and may even pose safety concerns.

[0118] The hydrogen peroxide used in the sterilizing and cleaning composition of the present invention can be ultrapure hydrogen peroxide. Impurities contained in ultrapure hydrogen peroxide include aluminum (10 ppt or less), iron (10 ppt or less), and sodium (5 ppt or less). Ultrapure hydrogen peroxide contains fewer impurities, which can improve the stability of the resulting sterilizing and cleaning composition.

[0119] <Acetic acid and / or its salts> The acetic acid used in the disinfecting and cleaning composition of the present invention may be any acetic acid commonly used in the art. The acetic acid salt is not particularly limited as long as it is an acetate salt that is alkaline when dissolved in water, and examples thereof include sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate, barium acetate, and ammonium acetate.

[0120] The concentration of acetic acid and / or a salt thereof in the sterilizing and cleaning composition of the present invention may be 0.01 to 70% by mass, preferably 0.05 to 60% by mass, more preferably 0.1 to 55% by mass, and even more preferably 0.2 to 50% by mass.

[0121] In the sterilizing and cleaning composition of the present invention, the concentration of acetic acid and / or a salt thereof may be 3.5 to 250 times the concentration of peracetic acid. In one embodiment of the present invention, the concentration of acetic acid and / or a salt thereof may be 3.5 to 250 times, 3.5 to 150 times, 3.5 to 100 times, 5 to 250 times, 5 to 150 times, 5 to 100 times, 10 to 250 times, 10 to 150 times, 10 to 100 times, or the like, the concentration of peracetic acid. In a preferred embodiment of the present invention, the concentration of acetic acid and / or a salt thereof may be 10 to 250 times, 10 to 150 times, or 10 to 100 times the concentration of peracetic acid. When the concentration of acetic acid and / or a salt thereof is within the above range, calcium scale such as calcium carbonate adhering to objects to be sterilized and cleaned can be sufficiently removed.

[0122] The acetic acid used in the sterilizing and cleaning composition of the present invention can be ultra-pure acetic acid. Impurities contained in ultra-pure acetic acid include aluminum (10 ppt or less), iron (10 ppt or less), and sodium (10 ppt or less). Ultra-pure acetic acid contains fewer impurities, which can improve the stability of the resulting sterilizing and cleaning composition.

[0123] <Peracetic acid> The peracetic acid used in the disinfecting and cleaning composition of the present invention may be any peracetic acid commonly used in the art.

[0124] The concentration of peracetic acid in the sterilizing and cleaning composition of the present invention may be 0.001 to 15% by mass. In one embodiment of the present invention, the concentration of peracetic acid in the sterilizing and cleaning composition may be, for example, but is not limited to, 0.001% by mass, 0.005% by mass, 0.01% by mass, 0.1% by mass, 0.3% by mass, 0.4% by mass, 0.5% by mass, 0.6% by mass, 1.0% by mass, 3.0% by mass, 4.0% by mass, 5.0% by mass, 10% by mass, or 15% by mass. In one embodiment of the present invention, the concentration of peracetic acid in the disinfecting and cleaning composition is, for example, 0.001 to 15% by mass, 0.001 to 10% by mass, 0.001 to 5% by mass, 0.001 to 3% by mass, 0.005 to 15% by mass, 0.005 to 10% by mass, 0.005 to 5% by mass, 0.005 to 3% by mass, 0.01 to 15% by mass, 0.01 to 10% by mass, 0.01 to 5% by mass, 0.01 to 3% by mass, 0.1 to 15% by mass, 0.1 to 10% by mass, 0.1 to 5% by mass, 0. The concentration of peracetic acid in the sterilizing and cleaning composition may be 1 to 3 mass%, 0.3 to 15 mass%, 0.3 to 10 mass%, 0.3 to 5 mass%, 0.3 to 3 mass%, 0.4 to 15 mass%, 0.4 to 10 mass%, 0.4 to 5 mass%, 0.4 to 3 mass%, 0.5 to 15 mass%, 0.5 to 10 mass%, 0.5 to 5 mass%, 0.5 to 3 mass%, 0.6 to 15 mass%, 0.6 to 10 mass%, 0.6 to 5 mass%, 0.6 to 3 mass%, 1.0 to 15 mass%, 1.0 to 10 mass%, 1.0 to 5 mass%, 1.0 to 3 mass%, etc. In one embodiment of the present invention, the concentration of peracetic acid in the sterilizing and cleaning composition may be preferably 0.001 to 10 mass%, more preferably 0.005 to 5 mass%, and even more preferably 0.01 to 3 mass%.

[0125] <Other ingredients> The disinfecting and cleaning composition of the present invention may further contain, as necessary, additives used in general disinfecting and cleaning agents, such as surfactants, thickeners, fragrances, colorants, hydrolases, etc. The remainder of the disinfecting and cleaning composition of the present invention, other than hydrogen peroxide, acetic acid and / or its salts, peracetic acid, and stabilizers and other additives added as needed, is mainly water.

[0126] The sterilizing and cleaning composition of the present invention can be used as is without dilution, or can be diluted to any concentration to form a diluted sterilizing and cleaning composition. Water is usually used as a diluent. Examples of water used as a diluent include pure water, ultrapure water, distilled water, purified water, water for injection, and tap water. The dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted sterilizing and cleaning composition to have a sterilizing and cleaning effect, but is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0127] C-2. Diluted composition for disinfection and cleaning The diluted disinfectant and cleaning composition of the present invention contains peracetic acid, acetic acid and / or a salt thereof, hydrogen peroxide, water, and a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, and further contains additional water as a diluent. Each component is as described above.

[0128] The diluted composition for sterilization and cleaning of the present invention is Assembling As described above, the dilution ratio is not particularly limited as long as it is a dilution ratio that allows the diluted composition for sterilization and cleaning to have a concentration that exhibits sterilization and cleaning effects, but is preferably 1 to 10,000 times, more preferably 1 to 1,000 times.

[0129] In one embodiment of the present invention, the diluted composition for sterilization and cleaning may have a peracetic acid concentration of 0.001 to 1.5 mass%, preferably 0.001 to 1.0 mass%, more preferably 0.005 to 0.5 mass%, and even more preferably 0.01 to 0.3 mass%.

[0130] In one embodiment of the present invention, the diluted composition for sterilization and cleaning may have a concentration of acetic acid and / or a salt thereof of 0.01 to 7 mass%, preferably 0.05 to 6 mass%, more preferably 0.1 to 5.5 mass%, and even more preferably 0.2 to 5 mass%.

[0131] In one embodiment of the present invention, the diluted composition for sterilization and cleaning may have a hydrogen peroxide concentration of 0.001 to 2.5% by mass, preferably 0.005 to 2% by mass, more preferably 0.01 to 1.5% by mass, and even more preferably 0.02 to 1.0% by mass.

[0132] In one embodiment of the present invention, the diluted composition for sterilization and cleaning contains 0.001 to 1.5 mass% peracetic acid, 0.01 to 7 mass% acetic acid and / or a salt thereof, 0.001 to 2.5 mass% hydrogen peroxide, and water, Contains a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, The pH value of the composition may be 4.0 to 10.0.

[0133] In one embodiment of the present invention, the concentration of the phosphorus-based stabilizer in the diluted composition for sterilization and cleaning may be 0.0001 to 0.05% by mass, preferably 0.0001 to 0.03% by mass, more preferably 0.0001 to 0.02% by mass, and even more preferably 0.0001 to 0.01% by mass.

[0134] In one embodiment of the present invention, the concentration of the carboxylic acid stabilizer in the diluted composition for disinfection and cleaning may be 0.0001 to 0.05% by mass, preferably 0.0001 to 0.03% by mass, more preferably 0.0001 to 0.02% by mass, and even more preferably 0.0001 to 0.01% by mass.

[0135] In another embodiment of the present invention, the diluted composition for disinfection and cleaning contains 0.001 to 1.5 mass% peracetic acid, 0.01 to 7 mass% acetic acid and / or a salt thereof, 0.001 to 2.5 mass% hydrogen peroxide, and water, Contains sodium stannate as an additive, The pH value of the composition may be 4.0 to 10.0.

[0136] In one embodiment of the present invention, the diluted composition for disinfection and cleaning may have a sodium stannate concentration of 0.0001 to 0.5% by mass, preferably 0.0001 to 0.1% by mass, more preferably 0.0001 to 0.05% by mass, and even more preferably 0.0001 to 0.02% by mass.

[0137] C-3. Method for producing disinfectant and cleaning composition and diluted disinfectant and cleaning composition In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) acetate The method may include a mixing step of mixing the above ingredients. This manufacturing method does not generate heat of neutralization and is easy to work with. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. The order in which the components are mixed may be arbitrary, and in the sterilizing and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0138] The acetate may be any acetate that is alkaline when dissolved in an aqueous solution, including, but not limited to, sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate, barium acetate, and ammonium acetate. In one embodiment of the present invention, the acetate may be sodium acetate. In another embodiment of the present invention, the acetate may be potassium acetate.

[0139] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) Alkali The method may include a mixing step of mixing the components. In this manufacturing method, neutralization heat is generated, which increases the parallel movement rate and accelerates the reaction. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. Each component is as described above. The components may be mixed in any order, and in the sterilizing and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0140] Examples of the alkali that can be used include, but are not limited to, sodium hydroxide, potassium hydroxide, lithium hydroxide, beryllium hydroxide, magnesium hydroxide, aluminum hydroxide, calcium hydroxide, rubidium hydroxide, strontium hydroxide, cesium hydroxide, barium hydroxide, and ammonia. In one embodiment of the present invention, the alkali may be sodium hydroxide. In another embodiment of the present invention, the alkali may be potassium hydroxide.

[0141] The above-mentioned production method using an alkali may include a step of mixing an additive, acetic acid, and an alkali, and then mixing the resulting mixture with aqueous hydrogen peroxide at 30 to 50° C. In this production method, heat of neutralization is generated, and the heat of neutralization generated by mixing the additive, acetic acid, and alkali can be utilized to mix the aqueous hydrogen peroxide at 30 to 50° C., thereby increasing the translation speed and accelerating the reaction.

[0142] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises mixing at least the following ingredients: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) one or more selected from phosphate, citrate, and Tris base The method may include a mixing step of mixing the components. In this manufacturing method, when a phosphate or a citrate is used as (iii), heat of neutralization is not generated, resulting in good workability. Furthermore, in this manufacturing method, when a Tris base is used as (iii), heat of neutralization is generated, which increases the translation speed and accelerates the reaction. When the aqueous solution reaches an equilibrium state, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. The order of mixing the components may be arbitrary, and in the sterilizing and cleaning composition of the present invention, the mixed components are in an equilibrium state.

[0143] When a tris base is used as (iii), the above production method may include a step of mixing an additive, acetic acid, and a tris base, and then mixing the resulting mixture with aqueous hydrogen peroxide at 30 to 50° C. In this production method, heat of neutralization is generated, and the heat of neutralization generated by mixing the additive, acetic acid, and tris base can be utilized to mix the aqueous hydrogen peroxide at 30 to 50° C., thereby increasing the translation rate and accelerating the reaction.

[0144] In one embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (A) and (B): Step (A) At least (i) an additive, (ii) hydrogen peroxide and acetic acid, and (iii) one or more selected from acetate, alkali, phosphate, citrate, and Tris base. and mixing the above components; Step (B) A step of leaving the aqueous solution (a) obtained in step (A) standing for one day or more. The aqueous solution (a) obtained in step (A) is allowed to stand in step (B), whereby the aqueous solution reaches an equilibrium state. In an embodiment using an acetate salt, the temperature at which the solution is allowed to stand in step (B) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for which the solution is allowed to stand in step (B) is preferably 1 day or more, and may be, for example, 2 days or more, 3 days or more, 5 days or more, 10 days or more, or 30 days or more. In an embodiment using an alkali or a Tris base, the reaction can be accelerated by the generation of heat of neutralization, as described above.

[0145] In yet another embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (C) to (E): Step (C) mixing at least (ii) hydrogen peroxide solution and acetic acid, and (i) an additive; Step (D) is a step of leaving the aqueous solution (c) obtained in Step (C) to stand for one day or more; Step (E) A step of mixing the aqueous solution (d) obtained in Step (D), (iii) one or more selected from acetate, alkali, phosphate, citrate, and Tris base, and water. The aqueous solution (c) obtained in step (C) is allowed to stand, thereby allowing the aqueous solution to reach an equilibrium state. The temperature at which the solution is allowed to stand in step (D) is preferably 20 to 60°C, more preferably 20 to 50°C. The time period for allowing the solution to stand in step (D) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, or 30 days or more. Thereafter, the aqueous solution (d) that has reached an equilibrium state is mixed with an acetate, an alkali, or one or more selected from a phosphate, a citrate, and a Tris base, and water.

[0146] The method for producing a sterilizing and cleaning composition of the present invention may further include adding a metal selected from the group consisting of Al, Zr, and Nb in the mixing step. Adding such a metal in the mixing step can improve the stability of the mixture during raw material mixing (blending). The metal added to the sterilizing and cleaning composition of the present invention may be added, for example, as a standard stock solution of the metal. In a preferred embodiment, the standard stock solution of the metal may be, for example, a standard stock solution with a concentration of 1,000 ppm. The concentration of the metal added to the sterilizing and cleaning composition of the present invention may be in the range of 1,000 ppb or less, for example, 500 ppb or less, 1 ppb to 200 ppb, 10 ppb to 150 ppb, or 50 to 100 ppb. In a preferred embodiment, the metal added in the mixing step is Al.

[0147] In one embodiment of the present invention, a method for preparing a diluted disinfecting and cleaning composition comprises mixing at least the following components: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) one or more selected from acetate, alkali, phosphate, citrate, and Tris base a mixing step of mixing the above ingredients; A dilution step of diluting the obtained mixture The aqueous solution may contain peracetic acid. When the aqueous solution reaches equilibrium, peracetic acid will also be present in the aqueous solution, and peracetic acid may be added in the mixing step. The components are as described above. In the method for producing a diluted composition for sterilization and cleaning of the present invention, the dilution step may include mixing the mixture obtained in the mixing step with water. The water used as a diluent may be, for example, pure water, ultrapure water, distilled water, purified water, water for injection, tap water, etc.

[0148] [Method of sterilization and cleaning using the sterilization and cleaning composition] The sterilizing and cleaning composition or the diluted sterilizing and cleaning composition of the present invention can be used for sterilizing and cleaning, for example, medical instruments, food and beverage containers, industrial wastewater, cooling water for air conditioning equipment, clothing, cooking utensils, tableware, bathrooms, kitchens, washing machines, bath heaters, furniture, and pets.

[0149] In one embodiment of the present invention, there is provided a method for sterilizing and cleaning medical instruments using the sterilizing and cleaning composition or the diluted sterilizing and cleaning composition. In the sterilizing and cleaning method of the present invention, the sterilizing and cleaning method for medical instruments may be any of a dipping method, a spraying method, and a coating method. In the sterilizing and cleaning method for medical instruments of the present invention, the amount of the sterilizing and cleaning composition or the diluted sterilizing and cleaning composition used and the sterilizing and cleaning time depend on the type and amount of microorganisms, Sterilization and The concentration can be appropriately selected depending on the concentration of the cleaning composition or diluted composition for disinfection and cleaning.

[0150] In the sterilization and cleaning method of the present invention, the medical instrument includes, but is not limited to, dialysis instruments, endoscopic instruments, surgical instruments, obstetric and urological instruments, anesthesia equipment, artificial respiration equipment, dental instruments, syringe needles, etc. In the sterilization and cleaning method of the present invention, the medical instrument is preferably dialysis instruments. [Example]

[0151] Examples of the present invention are shown below. However, these examples are merely illustrative of embodiments of the present invention and are not intended to limit the scope of the present invention.

[0152] [Embodiment A] <Method for measuring hydrogen peroxide concentration> In the present invention, the hydrogen peroxide concentration of the sterilizing and cleaning composition (peracetic acid composition) was measured by oxidation-reduction titration. Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 250 mL Erlenmeyer flask, and 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid were added to prepare a test solution. A few drops of ferroin test solution were added to this test solution, and the solution was titrated with 0.1 mol / L cerium (IV) sulfate solution to calculate the hydrogen peroxide concentration.

[0153] <Method for measuring acetic acid and peracetic acid concentrations> In the present invention, the acetic acid and peracetic acid concentrations of the sterilizing and cleaning composition (peracetic acid composition) were measured by neutralization titration. Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 100 mL beaker, and approximately 50 mL of pure water was added to prepare a test solution. This test solution was titrated with 0.1 mol / L sodium hydroxide solution, and the acetic acid concentration was calculated from the amount added at the first inflection point, and the peracetic acid concentration was calculated from the amount added from the first inflection point to the second inflection point.

[0154] <Stability test> In the present invention, the total peroxide concentration of the sterilization and cleaning composition (peracetic acid composition) was measured by iodometric titration. Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 250 mL Erlenmeyer flask. 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid were added, followed by 10 mL of 10% by weight potassium iodide solution and a few drops of 1% by weight ammonium molybdate solution to prepare a test solution. A 0.1 mol / L sodium thiosulfate solution was added dropwise to this test solution, and the liberated iodine was quantified using starch as an indicator, with the end point being when the blue-purple color of the solution disappeared and became colorless. The total peroxide concentration was calculated in terms of hydrogen peroxide from the amount of iodine.

[0155] The stability of the sterilizing and cleaning composition (peracetic acid composition) was calculated as the ratio of the total peroxide concentration at the time of measurement to the total peroxide concentration (TPO) at the time of preparation, which was set at 100, and evaluated as follows. A: 93% or more (good) B: 90% to less than 93% (usable) C: Less than 90% (not practical)

[0156] <Spore suspension preparation > A standard strain of Bacillus cereus (Microbiologics, product name: Bacillus cereus ATCC10876) was spread on NGKG agar medium (AZONE, product name: Sanispec Raw Medium) and cultured at 35°C for 7 days. Sterilized distilled water was added to this agar medium, and the cells were scraped and collected with a ConnLage rod, then centrifuged and washed with sterilized distilled water. To obtain only the spore form, the cells were heated at 80°C for 10 minutes, and the surviving cells were used as a spore suspension.

[0157] <Bactericidal test> The sterilizing and cleaning composition of the present invention (peracetic acid composition) was diluted 40 to 300 times with sterilized distilled water to prepare sample solutions with a peracetic acid concentration of 90 to 200 ppm. 50 μL of the spore suspension was added to 5 mL of each sample solution, and the solution was allowed to react at 25°C for 120 minutes. After the reaction, the solution was diluted 10 times with 0.1 mol / L sterilized sodium thiosulfate solution and cultured at 35°C for 48 hours using a Bacillus cereus detection medium (manufactured by Nissui Pharmaceutical Co., Ltd., product name: Compact Dry X-BC), and the viable cell count was measured. The viable cell count of the spore suspension was also measured, and this was recorded as the initial viable cell count.

[0158] <Example A-1> 21.0 g of purified water was mixed with 0.02 g of 60% by weight 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, Italmatch Japan Co., Ltd., product name: Dequest 2010), 0.01 g of disodium ethylenediaminetetraacetic acid dihydrate (EDTA 2Na 2HO, MP Biomedicals, Inc.), 55.8 g of sodium acetate trihydrate (Fujifilm Wako Pure Chemical Industries, Ltd.), 9.0 g of glacial acetic acid (Showa Denko K.K., product name: 99% Pure Acetic Acid), 14.2 g of 45% by weight hydrogen peroxide (Mitsubishi Gas Chemical Company, Inc., product name: SER45), and 0.01 g of polyoxyethylene (4.5) lauryl ether acetate (Kao Corporation, product name: Kao Akipo RLM-45) in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After mixing, the mixture was aged at 25°C for 7 days to obtain a sterilizing and cleaning composition (peracetic acid composition) containing 5.8% by mass of hydrogen peroxide, 8.6% by mass of acetic acid, 0.45% by mass of peracetic acid, 33.6% by mass of sodium acetate, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, 0.01% by mass of disodium ethylenediaminetetraacetate, and 0.01% by mass of polyoxyethylene (4.5) lauryl ether acetate, with a pH of 5.1. The resulting sterilizing and cleaning composition (peracetic acid composition) was subjected to stability tests and sterilization tests. The results are shown in Tables A-1 and A-2 (Tables 1 and 2).

[0159] <Examples A-2 to A-4, Reference Example A-1> A sterilizing and cleaning composition was prepared in the same manner as in Example A-1, except that the formulation was as shown in Table A-1. A stability test and a sterilization test were carried out on the obtained sterilizing and cleaning composition (peracetic acid composition). The results are shown in Tables A-1 and A-2.

[0160] <Comparative example A-1> 37.1 g of pure water, 0.2 g of pyrophosphoric acid (manufactured by Junsei Chemical Co., Ltd., product name: diphosphoric acid), 37.5 g of glacial acetic acid (manufactured by Showa Denko K.K., product name: 99% pure acetic acid), and 14.2 g of 45% by mass hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc., product name: SER45) were mixed in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After mixing, the mixture was aged at 50°C for 2 days and at 25°C for 2 days to obtain a sterilization and cleaning composition (peracetic acid composition) containing 7.5% by mass hydrogen peroxide, 32.4% by mass acetic acid, 6.0% by mass peracetic acid, 0.2% by mass pyrophosphoric acid, and a pH of 1.1. The obtained sterilization and cleaning composition (peracetic acid composition) was subjected to stability tests and sterilization tests. The results are shown in Tables A-1 and A-2.

[0161] As described above, the present invention can provide a composition for sterilizing and cleaning medical instruments, which contains a highly stable peroxide and whose wastewater meets sewage discharge standards.

[0162] [Table 1]

[0163] [Table 2]

[0164] [Embodiment B] <Method for measuring hydrogen peroxide concentration in disinfecting and cleaning compositions> In the present invention, the hydrogen peroxide concentration of the sterilizing and cleaning composition (peracetic acid composition) was measured by oxidation-reduction titration. Specifically, approximately 0.1 g of the sterilizing and cleaning composition sample was precisely weighed and placed in a 250 mL Erlenmeyer flask, and 10 mL of 20% by mass sulfuric acid was added to prepare a test solution. A few drops of ferroin test solution were added to this test solution, and the solution was titrated with 0.1 mol / L cerium (IV) sulfate solution to calculate the hydrogen peroxide concentration.

[0165] <Method for measuring acetic acid and peracetic acid concentrations in disinfecting and cleaning compositions> In the present invention, the acetic acid concentration and peracetic acid concentration of the sterilizing and cleaning composition (peracetic acid composition) were measured by neutralization titration. Specifically, approximately 0.1 g of a sample of the sterilizing and cleaning composition was precisely weighed and placed in a 100 mL beaker, and approximately 50 mL of pure water was added to prepare a test solution. This test solution was titrated with 0.1 mol / L sodium hydroxide solution, and the acetic acid concentration was calculated from the amount added at the first inflection point, and the peracetic acid concentration was calculated from the amount added from the first inflection point to the second inflection point.

[0166] <Stability test of disinfectant and cleaning composition> In the present invention, the total peroxide concentration of the sterilizing and cleaning composition (peracetic acid composition) was measured by iodometric titration. Specifically, approximately 0.1 g of a sample of the sterilizing and cleaning composition was precisely weighed and placed in a 250 mL Erlenmeyer flask. 100 mL of pure water and 10 mL of 20% by weight sulfuric acid were added, followed by 10 mL of 10% by weight potassium iodide solution and a few drops of 1% by weight ammonium molybdate solution to prepare a test solution. A 0.1 mol / L sodium thiosulfate solution was added dropwise to this test solution, and the liberated iodine was quantified using starch as an indicator, with the end point being when the blue-purple color of the solution disappeared and became colorless. The total peroxide concentration was calculated in terms of hydrogen peroxide from the amount of iodine.

[0167] The stability of the sterilizing and cleaning composition (peracetic acid composition) of the present invention was calculated as the ratio of the total peroxide concentration at the time of measurement to the total peroxide concentration (TPO) at the time of preparation, which was set at 100, and evaluated as follows. A: 93% or more (good) B: 90% to less than 93% (usable) C: Less than 90% (not practical)

[0168] <Preparation of spore suspension> A standard strain of Bacillus cereus (Microbiologics, product name: Bacillus cereus ATCC10876) was spread on NGKG agar medium (AZONE, product name: Sanispec Raw Medium) and cultured at 35°C for 7 days. Sterilized distilled water was added to this agar medium, and the bacteria were scraped and collected with a ConnLage stick, then centrifuged and washed with sterilized distilled water. To obtain only the spore form, the bacteria were heated at 80°C for 10 minutes, and the surviving bacteria were used as a spore suspension.

[0169] <Bactericidal test> The aqueous solution for sterilization and cleaning (peracetic acid composition) of the present invention was diluted with sterilized distilled water to prepare a sample solution so that the concentration of peracetic acid was 1000 ppm. 50 μL of the spore suspension was added to 5 mL of each sample solution, and the solution was allowed to react at 25°C for 5 to 30 minutes. After the reaction, the solution was diluted 10-fold with 0.1 mol / L sterilized sodium thiosulfate solution, and cultured at 35°C for 48 hours using a Bacillus cereus detection medium (manufactured by Nissui Pharmaceutical Co., Ltd., product name: Compact Dry X-BC), and the viable cell count was measured. The viable cell count of the spore suspension was also measured, and this was recorded as the initial viable cell count.

[0170] <Creating calcium carbonate scale> Calcium chloride (Fujifilm Wako Pure Chemical Industries, Ltd.) and sodium bicarbonate (Fujifilm Wako Pure Chemical Industries, Ltd.) were dissolved in pure water to obtain calcium carbonate. cormorant A calcium carbonate aqueous solution (900 mg / L as CaCO3) was prepared. A total of 20 mL of calcium carbonate aqueous solution was dropped onto a SUS316 plate (thickness 1.0 × length 40 × width 40 mm) while heating it at 120 °C to create calcium carbonate scale. <Scale removal test> The aqueous solution for sterilization and cleaning (peracetic acid composition) of the present invention was diluted with distilled water to prepare a sample solution with a peracetic acid concentration of 200 ppm. A SUS316 plate with calcium carbonate scale attached was immersed in 10 mL of each sample solution for 1 hour, then washed with 10 mL of pure water and dried. The change in weight of the SUS316 plate with calcium carbonate scale attached before and after immersion in the sample solution was taken as the amount of scale removal. The amount of scale removal was shown as a relative value, with the value described in Comparative Example 1 being taken as 1. The larger the value of the amount of scale removal, the higher the scale removal ability.

[0171] <Protein adsorption> Bovine serum albumin (Fujifilm Wako Pure Chemical Industries, Ltd.) was used as the protein. Bovine serum albumin was dissolved in pure water to prepare a 0.3% by mass albumin solution. Approximately 0.5 g of SUS304 balls (AZONE Corporation) were placed in a sample boat for solid TC measurement, and 1 mL of the albumin solution was added dropwise. The sample was then dried in vacuum at 40°C for 2 hours to allow the albumin to be adsorbed onto the SUS304 balls.

[0172] <Protein removal test> The aqueous solution for sterilization and cleaning (peracetic acid composition) of the present invention was diluted with distilled water to prepare a sample solution with a peracetic acid concentration of 200 ppm. A sample boat for solid TC measurement containing SUS304 spheres with albumin adsorbed thereon was placed in 20 mL of each sample solution and shaken in a water bath at 40°C for 1 hour. After that, the sample was washed with 10 mL of pure water and vacuum dried at 40°C for 2 hours. The total carbon amount was measured using a solid TC measurement device (Shimadzu Corporation, product name: TOC-VCSN, SSM-5000A), and the amount of residual protein was calculated from the carbon amount. The residual protein Amount is shown as a relative value when the value described in Comparative Example 1 is set to 1. The smaller the residual protein amount value, the higher the protein removal ability.

[0173] <Example B-1> 35% by mass of hydrogen peroxide solution (manufactured by Mitsubishi Gas Chemical Company, Inc.: 35% hydrogen peroxide), glacial acetic acid (manufactured by Showa Denko K.K., product name: 99% Pure Acetic Acid), pyrophosphoric acid (manufactured by Junsei Chemical Co., Ltd., product name: diphosphoric acid), pure water, polyoxyethylene (10) lauryl ether acetic acid (manufactured by Kao Corporation, product name: Kao Akipo RLM-100) were mixed to a concentration of 11.5% by mass of hydrogen peroxide, 37.5% by mass of acetic acid, 0.2% by mass of pyrophosphoric acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. After mixing, the mixture was left to stand at 25 ° C for 11 days to obtain a sterilization and cleaning composition containing 6.5% by mass of peracetic acid, 8.4% by mass of hydrogen peroxide, 32.5% by mass of acetic acid, 0.2% by mass of pyrophosphoric acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. The obtained sterilization and cleaning composition was subjected to a sterilization test, a stability test, a scale removal test, and a protein removal test. The results are shown in Tables B-1, B-3, and B-5 (shown in [Table 3], [Table 5], and [Table 7]).

[0174] <Examples B-2 to B-13, Comparative Examples B-1 to B-10> In the same manner as in Example B-1, disinfecting and cleaning compositions with the concentrations shown in Tables B-1 and B-2 (shown in Tables 3 and 4) were obtained. Disinfection tests, stability tests, scale removal tests, and protein removal tests were carried out on the disinfecting and cleaning compositions. The results are shown in Tables B-1 to B-5 (shown in Tables 3 to 7).

[0175] <Example B-14> 35% by mass of hydrogen peroxide solution (Mitsubishi Gas Chemical Co., Ltd.: 35% hydrogen peroxide), glacial acetic acid (Showa Denko K.K., product name: 99% pure acetic acid), pyrophosphoric acid (Junsei Chemical Co., Ltd., product name: diphosphoric acid), pure water, polyoxyethylene (10) lauryl ether acetic acid (Kao Corporation, product name: Kao Akipo RLM-100) was used to obtain 15.2% by mass of hydrogen peroxide, 9.3% by mass of acetic acid, 0.05% by mass of pyrophosphoric acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. After mixing, the mixture was left to stand at 25 ° C. for 11 days to obtain a sterilization and cleaning composition containing 1.6% by mass of peracetic acid, 14.5% by mass of hydrogen peroxide, 8.1% by mass of acetic acid, 0.05% by mass of pyrophosphoric acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. The obtained disinfecting and cleaning compositions were subjected to disinfection tests, stability tests, scale removal tests, and protein removal tests, and the results are shown in Tables B-1 and B-3.

[0176] <Example B-15, Comparative Example B-11> In the same manner as in Example B-14, disinfecting and cleaning compositions having the concentrations shown in Tables B-1 and B-2 were obtained. The disinfecting and cleaning compositions were subjected to disinfection tests and stability tests. The results are shown in Tables B-1 to B-4.

[0177] <Example B-16> A 35% by mass solution of hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc.: 35% hydrogen peroxide), glacial acetic acid (manufactured by Showa Denko K.K., product name: 99% pure acetic acid), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) (manufactured by Italmatch Japan Co., Ltd., product name: Dequest 2010), pure water, and polyoxyethylene (10) lauryl ether acetic acid (manufactured by Kao Corporation, product name: Kao Akipo RLM-100) were mixed to a concentration of 12.1% by mass of hydrogen peroxide, 59.1% by mass of acetic acid, 0.7% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. After mixing, the mixture was allowed to stand at 25°C for 11 days to obtain a sterilizing and cleaning composition containing 13.7% by mass of peracetic acid, 5.4% by mass of hydrogen peroxide, 48.4% by mass of acetic acid, 0.7% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. The obtained sterilizing and cleaning composition was subjected to a sterilization test and a stability test. The results are shown in Tables B-1 and B-3.

[0178] <Example B-17, Comparative Example B-12> In the same manner as in Example B-16, disinfectant and cleaning compositions having the concentrations shown in Tables B-1 and B-Table 2 were obtained. The disinfectant and cleaning compositions were subjected to disinfection tests and stability tests. The results are shown in Tables B-1 to B-4.

[0179] <Example B-18> A 35% by mass solution of hydrogen peroxide (35% hydrogen peroxide manufactured by Mitsubishi Gas Chemical Company, Inc.), glacial acetic acid (99% pure acetic acid manufactured by Showa Denko K.K.), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) (Dequest 2010 manufactured by Italmatch Japan Co., Ltd.), purified water, and polyoxyethylene (10) lauryl ether acetic acid (Kao Corporation, product name: Kao Akipo RLM-100) were mixed to a final concentration of 20.3% by mass of hydrogen peroxide, 10.2% by mass of acetic acid, 0.1% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. After mixing, the mixture was allowed to stand at 25°C for 11 days to obtain a sterilizing and cleaning composition containing 2.4% by mass of peracetic acid, 19.3% by mass of hydrogen peroxide, 8.4% by mass of acetic acid, 0.1% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 1.0% by mass of polyoxyethylene (10) lauryl ether acetic acid. Sterilization tests and stability tests were conducted on the resulting sterilizing and cleaning composition. The results are shown in Tables B-1 to B-4.

[0180] <Example B-19, Comparative Example B-13> In the same manner as in Example B-18, disinfecting and cleaning compositions having the concentrations shown in Tables B-1 and B-2 were obtained. The disinfecting and cleaning compositions were subjected to disinfection tests and stability tests. The results are shown in Tables B-1 to B-4.

[0181] [Table 3]

[0182] [Table 4]

[0183] [Table 5]

[0184] [Table 6]

[0185] [Table 7]

[0186] As described above, according to the present invention, by adding a special anionic surfactant (polyoxyethylene lauryl ether acetic acid) to peracetic acid, it has been shown that the stability and bactericidal properties can be improved compared to conventional aqueous solutions of peracetic acid, and that a bactericidal and cleaning composition having scale removal ability and protein removal ability can be provided.

[0187] [Embodiment C]

[0188] <Method for measuring hydrogen peroxide concentration in disinfecting and cleaning compositions> In the present invention, the hydrogen peroxide concentration of the sterilizing and cleaning composition (peracetic acid composition) was measured by oxidation-reduction titration. Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 250 mL Erlenmeyer flask, and 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid were added to prepare a test solution. A few drops of ferroin test solution were added to this test solution, and the solution was titrated with 0.1 mol / L cerium (IV) sulfate solution to calculate the hydrogen peroxide concentration.

[0189] <Method for measuring acetic acid and peracetic acid concentrations in disinfecting and cleaning compositions> In the present invention, the acetic acid concentration and peracetic acid concentration of the sterilizing and cleaning composition (peracetic acid composition) were measured by neutralization titration. Specifically, approximately 0.1 g of a sample of the sterilizing and cleaning composition was precisely weighed and placed in a 100 mL beaker, and approximately 50 mL of pure water was added to prepare a test solution. This test solution was titrated with 0.1 mol / L sodium hydroxide solution, and the acetic acid concentration was calculated from the amount added at the first inflection point, and the peracetic acid concentration was calculated from the amount added from the first inflection point to the second inflection point.

[0190] <Total Peroxide Concentration (TPO) in Disinfecting and Cleaning Compositions> In the present invention, the total peroxide concentration of the sterilization and cleaning composition (peracetic acid composition) was measured by iodometric titration. Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 250 mL Erlenmeyer flask. 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid were added, followed by 10 mL of 10% by weight potassium iodide solution and a few drops of 1% by weight ammonium molybdate solution to prepare a test solution. A 0.1 mol / L sodium thiosulfate solution was added dropwise to this test solution, and the liberated iodine was quantified using starch as an indicator, with the end point being when the blue-purple color of the solution disappeared and became colorless. The total peroxide concentration was calculated in terms of hydrogen peroxide from the amount of iodine.

[0191] <Stability of disinfecting and cleaning compositions> The stability of the sterilizing and cleaning composition (peracetic acid composition) of the present invention was calculated as the ratio of the total peroxide concentration at the time of measurement to the total peroxide concentration (TPO) at the time of preparation, which was set at 100.

[0192] <Spore suspension preparation > A standard strain of Bacillus cereus (Microbiologics, product name: Bacillus cereus ATCC10876) was spread on NGKG agar medium (AZONE, product name: Sanispec Raw Medium) and cultured at 35°C for 7 days. Sterilized distilled water was added to this agar medium, and the cells were scraped and collected with a ConnLage rod, then centrifuged and washed with sterilized distilled water. To obtain only the spore form, the cells were heated at 80°C for 10 minutes, and the surviving cells were used as a spore suspension.

[0193] <Bactericidal test> The sterilizing and cleaning composition of the present invention (peracetic acid composition) was diluted 40 to 300 times with sterilized distilled water to prepare sample solutions with a peracetic acid concentration of 90 to 200 ppm. 50 μL of the spore suspension was added to 5 mL of each sample solution, and the solution was allowed to react at 25°C for 120 minutes. After the reaction, the solution was diluted 10 times with 0.1 mol / L sterilized sodium thiosulfate solution and cultured at 35°C for 48 hours using a Bacillus cereus detection medium (manufactured by Nissui Pharmaceutical Co., Ltd., product name: Compact Dry X-BC), and the viable cell count was measured. The viable cell count of the spore suspension was also measured, and this was recorded as the initial viable cell count.

[0194] <Example C-1> 22.0 g of purified water, 0.17 g of 60% by weight 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, Italmatch Japan Co., Ltd., product name: Dayquest 2010), 0.11 g of disodium ethylenediaminetetraacetate dihydrate (EDTA 2Na 2HO, MP Biomedicals, Inc.), 18.0 g of glacial acetic acid (Showa Denko K.K., product name: 99% Pure Acetic Acid), 45.6 g of sodium acetate trihydrate (Fujifilm Wako Pure Chemical Industries, Ltd.), and 14.2 g of 45% by weight hydrogen peroxide solution (Mitsubishi Gas Chemical Company, Inc., product name: SER45) were mixed in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After preparation, the mixture was aged at 25°C for 7 days to obtain a peracetic acid composition for use in cleaning dialysis equipment, containing 5.6% by mass of hydrogen peroxide, 17.1% by mass of acetic acid, 1.1% by mass of peracetic acid, 0.1% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and 0.1% by mass of disodium ethylenediaminetetraacetate (EDTA·2Na), with a pH of 5.1. The total peroxide concentration (TPO) of the resulting peracetic acid composition was measured 14 days after preparation at 25°C, and the stability was calculated. The results are shown in Table C-1 (Table 8). The stability was evaluated as follows: A: 94.5% or more (good) B: 93.8% or more but less than 94.5% (usable) C: Less than 93.8% (not practical)

[0195] <Examples C-2 to C-14, Comparative Examples C-1 to C-6> A disinfectant and cleaning composition having the concentration shown in Table C-1 was obtained in the same manner as in Example C-1, except that the additives listed in Table C-1 were used. The total peroxide concentration (TPO) of each disinfectant and cleaning composition was measured, and the stability was calculated. The results are shown in Table C-1. The DTPP, sodium stannate 3H2O, and DTPA used in the table were as follows: Diethylenetriaminepentamethylenephosphonic acid (DTPP, purified product manufactured by Mitsubishi Gas Chemical Company, Inc.) Sodium stannate trihydrate (Na stannate·3H2O, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Diethylenetriaminepentaacetic acid (DTPA, manufactured by Dojindo Laboratories, Ltd.)

[0196] <Examples C-15 to C-20> A disinfectant and cleaning composition having the concentration shown in Table C-2 was obtained in the same manner as in Example C-1, except that the formulation was as shown in Table C-2 (shown in [Table 9]) and the composition was aged at 50°C for 1 day. The total peroxide concentration (TPO) of the disinfectant and cleaning composition was measured after preparation, aging at 50°C for 1 day, and aging at 25°C for 20 days, and the stability was calculated. The results are shown in Table C-2. The stability was evaluated as follows. A: 93.0% or more (good) B: 90.0% or more but less than 93.0% (usable) C: Less than 90.0% (not practical)

[0197] <Examples C-21 to C-22, Comparative Examples C-7 to C-12> A disinfectant and cleaning composition having the concentration shown in Table C-3 was obtained in the same manner as in Example C-1, except that the formulation was as shown in Table C-3 (shown in [Table 10]) and the composition was aged at 25°C for 21 days. The total peroxide concentration (TPO) of the disinfectant and cleaning composition was measured 21 days after preparation at 25°C, and the stability was calculated. The results are shown in Table C-3. The stability was evaluated as follows. A: 98.0% or more (good) B: 96.0% or more but less than 98.0% (practical) C: Less than 96.0% (not practical)

[0198] The 50% phytic acid and NaOH used in the table were as follows: 50% by weight phytic acid solution (50% phytic acid, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Sodium hydroxide (NaOH, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)

[0199] <Examples C-23 to C-25, Comparative Examples C-13 to C-14> A disinfectant and cleaning composition having the concentration shown in Table C-4 was obtained in the same manner as in Example C-21, except that the formulation was as shown in Table C-4 (shown in [Table 11]). The total peroxide concentration (TPO) of the disinfectant and cleaning composition was measured 21 days after preparation at 25°C, and the stability was calculated. The results are shown in Table C-4. The stability was evaluated as follows. A: 97.0% or more (good) B: 94.0% or more but less than 97.0% (practical) C: Less than 94.0% (not practical)

[0200] The pyrophosphates shown in the table were as follows: Pyrophosphate (Junsei Chemical Co., Ltd.) ceremony Co., Ltd., product name: diphosphate)

[0201] <Comparative examples C-15~C-21> A disinfectant and cleaning composition having the concentration shown in Table C-5 was obtained in the same manner as in Example C-21, except that the formulation was as shown in Table C-5 (shown in [Table 12]) and the composition was aged at 25°C for 11 days. 69 After 10 days, the total peroxide concentration (TPO) was measured and the stability was calculated. The results are shown in Table C-5. The stability was evaluated as follows: A: 97.0% or more (good) B: 93.0% or more but less than 97.0% (practical) C: Less than 93.0% (not practical)

[0202] The dipicolinic acid and EDTMP used in the table were as follows: Dipicolinic acid (Fujifilm Wako Pure Chemical Industries, Ltd.) Ethylenediaminetetramethylenephosphonic acid (EDTMP, manufactured by Tokyo Chemical Industry Co., Ltd.)

[0203] [Table 8]

[0204] [Table 9-1]

[0205] [Table 9-2]

[0206] [Table 10-1]

[0207] [Table 10-2]

[0208] [Table 11]

[0209] [Table 12]

[0210] <Examples C-26 to C-29> The results of an investigation into the method for producing the sterilizing and cleaning composition of the present invention are shown in Table C-6 below (Table 13). In Examples C-26 and C-28, which used alkali, an increase in reaction rate due to heat of neutralization was observed compared to Examples C-27 and C-29, which used acetate.

[0211] [Table 13]

[0212] <Example C-101> 20.0 g of purified water, 0.02 g of 60% by weight 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, Italmatch Japan Co., Ltd., product name: Dequest 2010), 0.01 g of disodium ethylenediaminetetraacetate dihydrate (EDTA 2Na 2HO, MP Biomedicals, Inc.), 28.4 g of 85% by weight potassium hydroxide (Fujifilm Wako Pure Chemical Industries, Ltd.), 37.4 g of glacial acetic acid (Showa Denko K.K., product name: 99% Pure Acetic Acid), and 14.2 g of 45% by weight hydrogen peroxide (Mitsubishi Gas Chemical Company, Inc., product name: SER45) were mixed in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After mixing, the mixture was aged at 50°C for 1 day and then cooled to 25°C to obtain a sterilizing and cleaning composition (peracetic acid composition) containing 5.7% by mass of hydrogen peroxide, 10.7% by mass of acetic acid, 0.33% by mass of peracetic acid, 44.7% by mass of potassium acetate, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 0.01% by mass of disodium ethylenediaminetetraacetate, with a pH of 5.1. A stability test was conducted on the resulting sterilizing and cleaning composition (peracetic acid composition). The results are shown in Table C-7 (Table 14).

[0213] <Examples C-102 to C-104, Comparative Example C-101> A sterilizing and cleaning composition (peracetic acid composition) was obtained in the same manner as in Example C-101, except that the formulation was changed as shown in Table C-7. A stability test was conducted on the obtained sterilizing and cleaning composition (peracetic acid composition). The results are shown in Table C-7. The stability was evaluated as follows. A: Good B: Practical C: Impractical Disodium hydrogen phosphate dodecahydrate (Fujifilm Wako Pure Chemical Industries, Ltd.) Sodium citrate dihydrate (Fujifilm Wako Pure Chemical Industries, Ltd.) Tris(hydroxymethyl)aminomethane ( alias: 2-amino- 2 -hydroxymethyl-1,3-propanediol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. 2-(4-(2-hydroxyethyl)-1-piperazinyl)ethanesulfonic acid (HEPES, Dojindo Laboratories)

[0214] [Table 14]

[0215] <Example C-105> 22.2 g of purified water, 0.02 g of 60% by weight 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, Italmatch Japan Co., Ltd., product name: Dayquest 2010), 0.01 g of disodium ethylenediaminetetraacetate dihydrate (EDTA 2Na 2HO, MP Biomedicals, Inc.), 18.0 g of ultrapure acetic acid (Kanto Chemical Co., Inc., standard: Ultrapur), 45.6 g of sodium acetate trihydrate (Fujifilm Wako Pure Chemical Industries, Ltd.), and 14.2 g of 45% by weight hydrogen peroxide solution (Mitsubishi Gas Chemical Company, Inc., product name: SER45) were mixed in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After preparation, the mixture was aged at 25°C for 7 days to obtain a disinfectant and cleaning composition (peracetic acid composition) containing 5.6% by mass of hydrogen peroxide, 17.1% by mass of acetic acid, 1.0% by mass of peracetic acid, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and 0.01% by mass of disodium ethylenediaminetetraacetate (EDTA·2Na), with a pH of 5.1. The total peroxide concentration (TPO) of the resulting disinfectant and cleaning composition (peracetic acid composition) was measured 42 days after preparation at 25°C, and the stability was calculated. The results are shown in Table C-8 (Table 15).

[0216] <Examples C-106 to C-108> A sterilizing and cleaning composition (peracetic acid composition) was obtained in the same manner as in Example C-105, except that the formulation was changed as shown in Table C-8. A stability test was conducted on the obtained sterilizing and cleaning composition (peracetic acid composition). The results are shown in Table C-8. The stability was evaluated as follows. A: Good B: Practical C: Impractical 35% by mass ultra-pure hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc., product name: UELM35)

[0217] [Table 15]

[0218] <Example C-109> 1.8 g of potassium aluminum sulfate dodecahydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was dissolved in 100 g of pure water to prepare an aqueous Al solution (Al: 1000 ppm). 31.0 g of purified water, 0.02 g of 60% by weight 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, Italmatch Japan Co., Ltd., product name: Dayquest 2010), 0.01 g of disodium ethylenediaminetetraacetate dihydrate (EDTA 2Na 2HO, MP Biomedicals, Inc.), 38.1 g of ultrapure acetic acid (Kanto Chemical Co., Ltd., standard: Ultrapur), 13.4 g of sodium hydroxide (Fujifilm Wako Pure Chemical Industries, Ltd.), 17.5 g of 35% by weight ultrapure hydrogen peroxide (Mitsubishi Gas Chemical Company, Inc., product name: UELM35), and 0.005 g of an aqueous solution (1000 ppm) of aluminum were mixed in a PE container. The total peroxide concentration at the time of mixing was 6.1%. After preparation, the mixture was aged at 25°C for 7 days to obtain a disinfectant and cleaning composition (peracetic acid composition) containing 5.6% by mass of hydrogen peroxide, 17.5% by mass of acetic acid, 1.1% by mass of peracetic acid, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and 0.01% by mass of disodium ethylenediaminetetraacetate (EDTA·2Na), with a pH of 5.1. The total peroxide concentration (TPO) of the resulting disinfectant and cleaning composition (peracetic acid composition) was measured 21 days after preparation at 25°C, and the stability was calculated. The results are shown in Table C-9 (Table 16).

[0219] <Examples C-110 to C-112, Reference Example C-102> A disinfectant and cleaning composition (peracetic acid composition) was obtained in the same manner as in Example C-109, except that the formulation was changed as shown in Table C-9. A stability test was conducted on the obtained disinfectant and cleaning composition (peracetic acid composition). The results are shown in Table C-9. The stability was evaluated as follows. A: Good B: Practical C: Impractical Zr standard solution (Zr: 1000 ppm) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Nb standard solution (Nb: 1000 ppm) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)

[0220] [Table 16]

[0221] As described above, the present invention has demonstrated that by adding a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive, it is possible to provide a composition for sterilizing and cleaning medical instruments, which has high peroxide stability and whose wastewater meets sewage discharge standards.

Claims

1. A disinfecting and cleaning composition comprising 0.001 to 30% by mass of peracetic acid, 0.001 to 30% by mass of hydrogen peroxide, 5 to 70% by mass of acetic acid and / or a salt thereof, 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, The disinfectant and cleaning composition has a pH value of 4.0 to 10.

0.

2. The composition according to claim 1, further comprising a phosphorus-based stabilizer and / or a carboxylic acid-based stabilizer as an additive.

3. The composition according to claim 2, comprising 0.0001 to 5% by mass of the phosphorus-based stabilizer and / or the carboxylic acid-based stabilizer.

4. The composition according to claim 2 or 3, wherein the phosphorus-based stabilizer is selected from the group consisting of pyrophosphoric acid or a salt thereof, phosphoric acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof, diethylenetriaminepentamethylenephosphonic acid (DTPP) or a salt thereof, nitrilotrismethylenephosphonic acid or a salt thereof, 2-phosphonobutane-1,2,4-tricarboxylic acid or a salt thereof, and ethylenediaminetetramethylenephosphonic acid or a salt thereof.

5. 4. The composition according to claim 2, wherein the carboxylic acid stabilizer comprises any one of ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethylenetriaminepentaacetic acid (DTPA) or a salt thereof, picolinic acid or a salt thereof, dipicolinic acid or a salt thereof, nitrilotriacetic acid or a salt thereof, N-(2-hydroxyethyl)ethylenediamine-N,N',N"-triacetic acid or a salt thereof, triethylenetetramine-N,N,N',N",N'",N'"-hexaacetic acid or a salt thereof, 1,3-propanediamine-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-propanol-N,N,N',N'-tetraacetic acid, N-(2-hydroxyethyl)iminodiacetic acid or a salt thereof, N,N-di(2-hydroxyethyl)glycine or a salt thereof, glycol ether diaminetetraacetic acid, and (S,S)-ethylenediamine-N,N'-disuccinic acid or a salt thereof.

6. The composition according to any one of claims 1 to 5, additional water A diluted disinfecting and cleaning composition comprising:

7. containing 0.001 to 1.5 mass% of peracetic acid, 0.001 to 2.5 mass% of hydrogen peroxide, 0.01 to 7 mass% of acetic acid and / or a salt thereof, and 0.00001 to 0.1 mass% of polyoxyethylene lauryl ether acetic acid or a salt thereof; The diluted composition according to claim 6, wherein the pH value of the diluted composition is from 4.0 to 10.

0.

8. A method for producing the composition according to any one of claims 1 to 5, comprising a mixing step of mixing at least the following components: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or a salt thereof

9. A method for producing the composition according to any one of claims 1 to 5, comprising a mixing step of mixing at least the following components: (i) Additives include phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) acetate (iv) Polyoxyethylene lauryl ether acetic acid or a salt thereof

10. A method for producing the composition according to any one of claims 1 to 5, comprising a mixing step of mixing at least the following components: (i) Additives include phosphorus-based stabilizers and / or carboxylic acid-based stabilizers (ii) Hydrogen peroxide and acetic acid (iii) alkali (iv) Polyoxyethylene lauryl ether acetic acid or a salt thereof

11. The method according to claim 10, wherein the additive, acetic acid, alkali, and polyoxyethylene lauryl ether acetic acid or a salt thereof are mixed, and then hydrogen peroxide solution is added at 30 to 50°C.

12. a mixing step of mixing at least the following components: A dilution step of diluting the obtained mixture A method for producing the diluted composition according to claim 6 or 7, comprising: (i) Hydrogen peroxide and acetic acid (ii) acetate or alkali (iii) Polyoxyethylene lauryl ether acetic acid or a salt thereof

13. The method for producing a diluted composition according to claim 12, wherein the dilution step comprises mixing the mixture obtained in the mixing step with water.

14. A method for sterilizing and cleaning medical instruments, which uses the composition according to any one of claims 1 to 5 or the diluted composition according to claim 6 or 7.

15. The sterilization and cleaning method according to claim 14, wherein the method for sterilizing and cleaning medical instruments is any one of a dipping method, a spraying method, and a coating method.

16. 16. The sterilization and cleaning method according to claim 14 or 15, wherein the medical instrument is a dialysis instrument.

17. A disinfecting and cleaning composition comprising 0.01 to 30% by mass of peracetic acid, 0.1 to 30% by mass of hydrogen peroxide, 5 to 60% by mass of acetic acid, 0.001 to 5% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof, and water, The disinfectant and cleaning composition has a pH value of 4.0 to 10.

0.

18. 20. The composition of claim 17 further comprising a stabilizer.

19. The composition of claim 18, comprising 0.01 to 5% by weight of the stabilizer.

20. 20. The composition of claim 18 or 19, wherein the stabilizer is a phosphorus-based stabilizer.

21. 21. The composition of claim 20, wherein the phosphorus-based stabilizer is selected from the group consisting of pyrophosphoric acid, phosphoric acid, 1-hydroxyethylidene-1,1-diphosphonic acid, nitrilotrismethylenephosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, and ethylenediaminetetramethylenephosphonic acid.

22. The composition of any one of claims 17 to 21, further comprising a chelating agent.

23. The composition of claim 22, comprising 0.01 to 2% by weight of a chelating agent.

24. 24. The composition of claim 22 or 23, wherein the chelating agent is selected from the group consisting of ethylenediaminetetraacetic acid, citric acid, malic acid, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and dipicolinic acid.

25. A composition according to any one of claims 17 to 24, additional water A diluted disinfecting and cleaning composition comprising:

26. 26. The diluted composition according to claim 25, comprising 0.001 to 0.2% by mass of peracetic acid, 0.01 to 2% by mass of hydrogen peroxide, 0.01 to 1% by mass of acetic acid, and 0.00001 to 0.1% by mass of polyoxyethylene lauryl ether acetic acid or a salt thereof.

27. A method for producing the composition according to any one of claims 17 to 24, comprising a mixing step of mixing at least the following components: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or a salt thereof

28. A method for producing the composition according to any one of claims 17 to 24, comprising the following steps (A) and (B): Step (A) A step of mixing at least acetic acid, a 30 to 65% by mass aqueous solution of hydrogen peroxide, and polyoxyethylene lauryl ether acetic acid or a salt thereof. Step (B): A step of leaving the aqueous solution (a) obtained in step (A) at 20 to 60°C for one day or more.

29. The method for producing a composition according to claim 28, wherein step (A) further comprises mixing a chelating agent.

30. A method for producing the composition according to any one of claims 17 to 24, comprising the following steps (C) to (E): Step (C) A step of mixing at least acetic acid and a 30 to 65% by mass aqueous solution of hydrogen peroxide. Step (D): A step of leaving the aqueous solution (c) obtained in step (C) at 20 to 60°C for one day or more. Step (E): A step of mixing the aqueous solution (d) obtained in Step (D), polyoxyethylene lauryl ether acetic acid or a salt thereof, and water.

31. The method for producing a composition according to claim 30, wherein a chelating agent is further mixed in step (E).

32. a mixing step of mixing at least the following components: A dilution step of diluting the obtained mixture A method for producing the diluted composition of claim 25 or 26, comprising: (i) Hydrogen peroxide solution (ii) acetic acid (iii) Polyoxyethylene lauryl ether acetic acid or a salt thereof

33. 33. The method for producing a diluted composition according to claim 32, wherein the diluting step comprises mixing the mixture obtained in the mixing step with water.

34. A method for sterilizing and cleaning medical instruments, comprising using the composition according to any one of claims 17 to 24 or the diluted composition according to claim 25 or 26.

35. 35. The method for sterilizing and cleaning medical instruments according to claim 34, wherein the method for sterilizing and cleaning medical instruments is a dipping method, a spraying method, or a coating method.

36. 36. The sterilization and cleaning method according to claim 34 or 35, wherein the medical instrument is a dialysis instrument.

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